TY - JOUR A1 - Voigt-Zimmermann, Susanne A1 - Stier, Karl-Heinz A1 - Lascheit, Thomas A1 - Kruse, Stephanie A. A1 - Blickensdorff, Maria A1 - Förster, Theresa A1 - Schumacher, Rebecca A1 - Burchert, Frank A1 - Ablinger, Irene A1 - Förster, Christine A1 - Wahl, Michael A1 - Schirmacher, Irene A1 - Ostermann, Frank A1 - Welke, Lisa-Marie A1 - Frank, Ulrike A1 - Zakariás, Lilla A1 - Salis, Christos A1 - Wartenburger, Isabell A1 - Krug, Ragna A1 - Stübner, Hanna A1 - Hoffmann, Sophie A1 - Heide, Judith ED - Fritzsche, Tom ED - Yetim, Özlem ED - Otto, Constanze ED - Adelt, Anne T1 - Spektrum Patholinguistik Band 11. Schwerpunktthema: Gut gestimmt: Diagnostik und Therapie bei Dysphonie N2 - Das 11. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Gut gestimmt: Diagnostik und Therapie bei Dysphonie« fand am 18.11.2017 in Potsdam statt. Das Herbsttreffen wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. Der vorliegende Tagungsband beinhaltet die Hauptvorträge zum Schwerpunktthema sowie Beiträge zu den Kurzvorträgen »Spektrum Patholinguistik« und der Posterpräsentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis. N2 - The Eleventh Autumn Meeting Patholinguistics (Herbsttreffen Patholinguistik) with its main topic »Well tuned: Diagnostics and therapy in dysphonia« took place in Potsdam on November 18 2017. This annual meeting has been organised since 2007 by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl). The present proceedings contain the keynote talks on the main topic as well as contributions from the short talks in the section »Spectrum Patholinguistics« and from the poster session covering a broad range of areas in speech/language therapy research and practice. T3 - Spektrum Patholinguistik - 11 KW - Patholinguistik KW - Sprachtherapie KW - Stimmtherapie KW - Stimmstörung KW - Dysphonie KW - patholinguistics KW - speech/language therapy KW - voice therapy KW - dysphonia Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-418574 SN - 978-3-86956-448-7 SN - 1866-9085 SN - 1866-9433 IS - 11 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Broscheit, Frank A1 - Bütow, Heike A1 - Gehrke, Albrecht A1 - Jahn, Gert A1 - Jürgens, Christoph A1 - Kißner, Karl-Heinz A1 - Klohn, Werner A1 - Knitschky, Wolfgang A1 - Mager, Franz-Peter A1 - Maier, Klaus A1 - Mühlberger, Wolfgang A1 - Mülders, Wolfgang A1 - Rappen-Röhlen, Beate A1 - Reinhardt, Karl Heinz A1 - Schmidt, Marianne A1 - Schmidtke, Kurt-Dietmar A1 - Volkmann, Hartmut A1 - Wetzel, Jürgen T1 - Seydlitz Erdkunde 1 : Ausgabe für Realschulen in Nordrhein-Westfalen Y1 - 1994 PB - Schroedel CY - Hannover ER - TY - JOUR A1 - Räder, Andy A1 - Heimann, Heinz-Dieter A1 - Partenheimer, Lutz A1 - Hahn, Peter-Michael A1 - Göse, Frank A1 - Tosch, Frank A1 - Berner, Elisabeth A1 - Schiefelbein, Claudia T1 - Portal = Erinnerungswürdig: 850 Jahre Mark Brandenburg BT - Die Potsdamer Universitätszeitung N2 - Aus dem Inhalt: - Erinnerungswürdig: 850 Jahre Mark Brandenburg - Chefsessel getauscht - Angebote für Schlüsselkompetenzen - Kampf gegen übergewichtige Kinder T3 - Portal: Das Potsdamer Universitätsmagazin - 07-09/2007 Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-440098 SN - 1618-6893 IS - 07-09/2007 ER - TY - JOUR A1 - Förstner, Bernd Rainer A1 - Böttger, Sarah Jane A1 - Moldavski, Alexander A1 - Bajbouj, Malek A1 - Pfennig, Andrea A1 - Manook, Andre A1 - Ising, Marcus A1 - Pittig, Andre A1 - Heinig, Ingmar A1 - Heinz, Andreas A1 - Mathiak, Klaus A1 - Schulze, Thomas G. A1 - Schneider, Frank A1 - Kamp-Becker, Inge A1 - Meyer-Lindenberg, Andreas A1 - Padberg, Frank A1 - Banaschewski, Tobias A1 - Bauer, Michael A1 - Rupprecht, Rainer A1 - Wittchen, Hans-Ulrich A1 - Rapp, Michael A. A1 - Tschorn, Mira T1 - The associations of positive and negative valence systems, cognitive systems and social processes on disease severity in anxiety and depressive disorders JF - Frontiers in psychiatry N2 - Background Anxiety and depressive disorders share common features of mood dysfunctions. This has stimulated interest in transdiagnostic dimensional research as proposed by the Research Domain Criteria (RDoC) approach by the National Institute of Mental Health (NIMH) aiming to improve the understanding of underlying disease mechanisms. The purpose of this study was to investigate the processing of RDoC domains in relation to disease severity in order to identify latent disorder-specific as well as transdiagnostic indicators of disease severity in patients with anxiety and depressive disorders. Methods Within the German research network for mental disorders, 895 participants (n = 476 female, n = 602 anxiety disorder, n = 257 depressive disorder) were recruited for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) and included in this cross-sectional study. We performed incremental regression models to investigate the association of four RDoC domains on disease severity in patients with affective disorders: Positive (PVS) and Negative Valance System (NVS), Cognitive Systems (CS) and Social Processes (SP). Results The results confirmed a transdiagnostic relationship for all four domains, as we found significant main effects on disease severity within domain-specific models (PVS: & beta; = -0.35; NVS: & beta; = 0.39; CS: & beta; = -0.12; SP: & beta; = -0.32). We also found three significant interaction effects with main diagnosis showing a disease-specific association. Limitations The cross-sectional study design prevents causal conclusions. Further limitations include possible outliers and heteroskedasticity in all regression models which we appropriately controlled for. Conclusion Our key results show that symptom burden in anxiety and depressive disorders is associated with latent RDoC indicators in transdiagnostic and disease-specific ways. KW - Research Domain Criteria KW - depression KW - anxiety disoders KW - disease severity KW - transdiagnostic KW - RDoC Y1 - 2023 U6 - https://doi.org/10.3389/fpsyt.2023.1161097 SN - 1664-0640 VL - 14 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Hansen, Dominique A1 - Niebauer, Josef A1 - Cornelissen, Veronique A1 - Barna, Olga A1 - Neunhaeuserer, Daniel A1 - Stettler, Christoph A1 - Tonoli, Cajsa A1 - Greco, Eugenio A1 - Fagard, Robert A1 - Coninx, Karin A1 - Vanhees, Luc A1 - Piepoli, Massimo F. A1 - Pedretti, Roberto A1 - Ruiz, Gustavo Rovelo A1 - Corra, Ugo A1 - Schmid, Jean-Paul A1 - Davos, Constantinos H. A1 - Edelmann, Frank A1 - Abreu, Ana A1 - Rauch, Bernhard A1 - Ambrosetti, Marco A1 - Braga, Simona Sarzi A1 - Beckers, Paul A1 - Bussotti, Maurizio A1 - Faggiano, Pompilio A1 - Garcia-Porrero, Esteban A1 - Kouidi, Evangelia A1 - Lamotte, Michel A1 - Reibis, Rona Katharina A1 - Spruit, Martijn A. A1 - Takken, Tim A1 - Vigorito, Carlo A1 - Völler, Heinz A1 - Doherty, Patrick A1 - Dendale, Paul T1 - Exercise prescription in patients with different combinations of cardiovascular disease risk factors BT - a consensus statement from the EXPERT working group JF - Sports medicine N2 - Whereas exercise training is key in the management of patients with cardiovascular disease (CVD) risk (obesity, diabetes, dyslipidaemia, hypertension), clinicians experience difficulties in how to optimally prescribe exercise in patients with different CVD risk factors. Therefore, a consensus statement for state-of-the-art exercise prescription in patients with combinations of CVD risk factors as integrated into a digital training and decision support system (the EXercise Prescription in Everyday practice & Rehabilitative Training (EXPERT) tool) needed to be established. EXPERT working group members systematically reviewed the literature for meta-analyses, systematic reviews and/or clinical studies addressing exercise prescriptions in specific CVD risk factors and formulated exercise recommendations (exercise training intensity, frequency, volume and type, session and programme duration) and exercise safety precautions, for obesity, arterial hypertension, type 1 and 2 diabetes, and dyslipidaemia. The impact of physical fitness, CVD risk altering medications and adverse events during exercise testing was further taken into account to fine-tune this exercise prescription. An algorithm, supported by the interactive EXPERT tool, was developed by Hasselt University based on these data. Specific exercise recommendations were formulated with the aim to decrease adipose tissue mass, improve glycaemic control and blood lipid profile, and lower blood pressure. The impact of medications to improve CVD risk, adverse events during exercise testing and physical fitness was also taken into account. Simulations were made of how the EXPERT tool provides exercise prescriptions according to the variables provided. In this paper, state-of-the-art exercise prescription to patients with combinations of CVD risk factors is formulated, and it is shown how the EXPERT tool may assist clinicians. This contributes to an appropriately tailored exercise regimen for every CVD risk patient. Y1 - 2018 U6 - https://doi.org/10.1007/s40279-018-0930-4 SN - 0112-1642 SN - 1179-2035 VL - 48 IS - 8 SP - 1781 EP - 1797 PB - Springer CY - Northcote ER - TY - JOUR A1 - Hausmann, Frank-Rutger A1 - Asholt, Wolfgang A1 - Thoma, Heinz A1 - Zimmermann, Margarete A1 - Schönert, Jörg A1 - Schröder, Konrad A1 - Raible, Wolfgang A1 - Ette, Ottmar T1 - 2. Podiumsdiskussion "Zukunft der Romanistik" Y1 - 2005 ER - TY - JOUR A1 - Herbst, Uta A1 - Fuchs, Iris Judith A1 - Teubner, Wera A1 - Seidel, Albrecht A1 - Frank, Heinz A1 - Steinberg, Pablo T1 - Malignant transformation of human colon epithelial cells by polycyclic aromatic hydrocarbons and heterocyclic aromatic amines Y1 - 2004 SN - 0028-1298 ER - TY - JOUR A1 - Nettels, Daniel A1 - Müller-Späth, Sonja A1 - Küster, Frank A1 - Hofmann, Hagen A1 - Haenni, Domminik A1 - Rüegger, Stefan A1 - Reymond, Luc A1 - Hoffmann, Armin S. A1 - Kubelka, Jan A1 - Heinz, Benjamin A1 - Gast, Klaus A1 - Best, Robert B. A1 - Schuler, Benjamin T1 - Single-molecule spectroscopy of the temperature-induced collapse of unfolded proteins N2 - We used single-molecule FRET in combination with other biophysical methods and molecular simulations to investigate the effect of temperature on the dimensions of unfolded proteins. With singlemolecule FRET, this question can be addressed even under nearnative conditions, where most molecules are folded, allowing us to probe a wide range of denaturant concentrations and temperatures. We find a compaction of the unfolded state of a small cold shock protein with increasing temperature in both the presence and the absence of denaturant, with good agreement between the results from single-molecule FRET and dynamic light scattering. Although dissociation of denaturant from the polypeptide chain with increasing temperature accounts for part of the compaction, the results indicate an important role for additional temperaturedependent interactions within the unfolded chain. The observation of a collapse of a similar extent in the extremely hydrophilic, intrinsically disordered protein prothymosin suggests that the hydrophobic effect is not the sole source of the underlying interactions. Circular dichroism spectroscopy and replica exchange molecular dynamics simulations in explicit water show changes in secondary structure content with increasing temperature and suggest a contribution of intramolecular hydrogen bonding to unfolded state collapse. Y1 - 2009 UR - http://www.pnas.org/content/106/49/20740.full.pdf+html SN - 0027-8424 ER - TY - JOUR A1 - Fritz, Markus A1 - Lokstein, Heiko A1 - Hackenberg, Dieter A1 - Welti, Ruth A1 - Roth, Mary A1 - Zähringer, Ulrich A1 - Fulda, Martin A1 - Hellmeyer, Wiebke A1 - Ott, Claudia A1 - Wolter, Frank P. A1 - Heinz, Ernst T1 - Channeling of eukaryotic diacylglycerol into the biosynthesis of plastidial phosphatidylglycerol N2 - Plastidial glycolipids contain diacylglycerol (DAG) moieties, which are either synthesized in the plastids (prokaryotic lipids) or originate in the extraplastidial compartment (eukaryotic lipids) necessitating their transfer into plastids. In contrast, the only phospholipid in plastids, phosphatidylglycerol (PG), contains exclusively prokaryotic DAG backbones. PG contributes in several ways to the functions of chloroplasts, but it is not known to what extent its prokaryotic nature is required to fulfill these tasks. As a first step toward answering this question, we produced transgenic tobacco plants that contain eukaryotic PG in thylakoids. This was achieved by targeting a bacterial DAG kinase into chloroplasts in which the heterologous enzyme was also incorporated into the envelope fraction. From lipid analysis we conclude that the DAG kinase phosphorylated eukaryotic DAG forming phosphatidic acid, which was converted into PG. This resulted in PG with 2-3 times more eukaryotic than prokaryotic DAG backbones. In the newly formed PG the unique Delta 3-trans-double bond, normally confined to 3-transhexadecenoic acid, was also found in sn-2- bound cis-unsaturated C18 fatty acids. In addition, a lipidomics technique allowed the characterization of phosphatidic acid, which is assumed to be derived from eukaryotic DAG precursors in the chloroplasts of the transgenic plants. The differences in lipid composition had only minor effects on measured functions of the photosynthetic apparatus, whereas the most obvious phenotype was a significant reduction in growth. Y1 - 2007 UR - http://www.jbc.org/ U6 - https://doi.org/10.1074/jbc.M606295200 SN - 0021-9258 ER - TY - JOUR A1 - Schmidt, Hans-Jürgen A1 - Baier, Frank W. A1 - Bleyer, Ulrich A1 - Hubrig, Swetlana A1 - Meister, Claudia-Veronika A1 - Schilbach, Elena A1 - Tiersch, Heinz T1 - Zum Wissenschaftler-Integrationsprogramm Y1 - 1994 ER - TY - JOUR A1 - Broscheit, Frank A1 - Bütow, Martin A1 - Englert, Wolfgang A1 - Jahn, Gert A1 - Klohn, Werner A1 - Knitschky, Wolfgang A1 - Reinecke, Hans-Joachim A1 - Müller, Helmut A1 - Reinhardt, Karl Heinz A1 - Schmidt, Marianne A1 - Schmidtke, Kurt-Dietmar A1 - Schöpflin, F. A1 - Starke, Rainer A1 - Vahldiek, B. W. A1 - Wehrs, Klaus A1 - Wetzel, Jürgen T1 - Seydlitz Erdkunde 2 Y1 - 1996 PB - Schroedel CY - Hannover ER - TY - JOUR A1 - Beeger, Helmut A1 - Bricks, Wolfgang A1 - Broscheit, Frank A1 - Bütow, Heike A1 - Bütow, Martin A1 - Englert, Wolfgang A1 - Gehrke, Albrecht A1 - Hallermann, Sigrun A1 - Jahn, Gert A1 - Kirsch, H. A1 - Klohn, Werner A1 - Markert, Wolfgang A1 - Meißgeier, Jürgen A1 - Mülders, Wolfgang A1 - Nicklaus, W. A1 - Reinhardt, Karl Heinz A1 - Robel, B. A1 - Schmidtke, Kurt-Dietmar A1 - Werner-Tokarski, D. T1 - Seydlitz Erdkunde 3 : Ausgabe Saarland Y1 - 1996 PB - Schroedel CY - Hannover ER - TY - JOUR A1 - Mueller-Nordhorn, Jacqueline A1 - Muckelbauer, Rebecca A1 - Englert, Heike A1 - Grittner, Ulrike A1 - Berger, Hendrike A1 - Sonntag, Frank A1 - Völler, Heinz A1 - Prugger, Christof A1 - Wegscheider, Karl A1 - Katus, Hugo A. A1 - Willich, Stefan N. T1 - Longitudinal association between body mass index and health-related quality of life JF - PLoS one N2 - Objective: Health-related quality of life (HRQoL) is an important outcome in individuals with a high risk for cardiovascular diseases. We investigated the association of HRQoL and body mass index (BMI) as an indicator for obesity. Design: Secondary longitudinal analysis of the ORBITAL study, an intervention study which included high-risk cardiovascular primary care patients with hypercholesterolemia and an indication for statin therapy. Methods: HRQoL was determined with the generic Short Form (SF)-12 health status instrument. Body weight and height were assessed at baseline and at months 6, 12, 18, 24, 30, and 36. We used a linear and a linear mixed-effects regression model to investigate the association between BMI and SF-12 summary scores at baseline as well as between change in BMI and SF-12 summary scores over 3 years. We adjusted for age, sex, smoking status, and in the longitudinal analysis also for the study arm and its interaction term with time. Results: Of the 7640 participants who completed the baseline questionnaire, 6726 participants (mean age: 61 years) were analyzed. The baseline BMI was inversely associated with physical and mental SF-12 summary scores (beta [95% CI] per 1 kg/ m(2) : -0.36 [-0.41; -0.30] and -0.05 [-0.11; -0.00], respectively). A significant association between the change in BMI and physical SF-12 summary scores over time was only present in women (-0.18 [-0.27; -0.09]) and only in obese participants (-0.19 [-0.29; -0.10]). A change in BMI was directly associated with mental SF-12 summary scores (0.12 [0.06; 0.19]) in the total population. Conclusion: Increases in BMI were associated with decreases in physical HRQoL, particularly in obese individuals and in women. In contrast, the mental HRQoL seemed to increase with increasing BMI over time. Thus, body weight management with respect to the HRQoL should be evaluated differentially by sex and body weight status. Y1 - 2014 U6 - https://doi.org/10.1371/journal.pone.0093071 SN - 1932-6203 VL - 9 IS - 3 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Hahn, Marc Benjamin A1 - Solomun, Tihomir A1 - Wellhausen, Robert A1 - Hermann, Sabrina A1 - Seitz, Harald A1 - Meyer, Susann A1 - Kunte, Hans-Jörg A1 - Zeman, Johannes A1 - Uhlig, Frank A1 - Smiatek, Jens A1 - Sturm, Heinz T1 - Influence of the Compatible Solute Ectoine on the Local Water Structure: Implications for the Binding of the Protein G5P to DNA JF - The journal of physical chemistry : B, Condensed matter, materials, surfaces, interfaces & biophysical chemistry N2 - Microorganisms accumulate molar concentrations of compatible solutes like ectoine to prevent proteins from denaturation. Direct structural or spectroscopic information on the mechanism and about the hydration shell around ectoine are scarce. We combined surface plasmon resonance (SPR), confocal Raman spectroscopy, molecular dynamics simulations, and density functional theory (DFT) calculations to study the local hydration shell around ectoine and its influence on the binding of a gene-S-protein (G5P) to a single-stranded DNA (dT(25)). Due to the very high hygroscopicity of ectoine, it was possible to analyze the highly stable hydration shell by confocal Raman spectroscopy. Corresponding molecular dynamics simulation results revealed a significant change of the water dielectric constant in the presence of a high molar ectoine concentration as compared to pure water. The SPR data showed that the amount of protein bound to DNA decreases in the presence of ectoine, and hence, the protein-DNA dissociation constant increases in a concentration-dependent manner. Concomitantly, the Raman spectra in terms of the amide I region revealed large changes in the protein secondary structure. Our results indicate that ectoine strongly affects the molecular recognition between the protein and the oligonudeotide, which has important consequences for osmotic regulation mechanisms. Y1 - 2015 U6 - https://doi.org/10.1021/acs.jpcb.5b09506 SN - 1520-6106 VL - 119 IS - 49 SP - 15212 EP - 15220 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Bluvshtein, Evgenia A1 - Glass, George A1 - Volohonsky, Gloria A1 - Yaakubowitz, Margalit A1 - Harness, Ella A1 - Smorodinsky, Nechama A1 - Seidel, Albrecht A1 - Frank, Heinz A1 - Stark, Avishay Abraham A1 - Steinberg, Pablo T1 - Inhibition of the hydrolytic and transpeptidatic activities of rat kidney gamma-glutamyltranspeptidase by specific monoclonal antibodies Y1 - 1999 ER - TY - JOUR A1 - Hansen, Dominique A1 - Dendale, Paul A1 - Coninx, Karin A1 - Vanhees, Luc A1 - Piepoli, Massimo F. A1 - Niebauer, Josef A1 - Cornelissen, Veronique A1 - Pedretti, Roberto A1 - Geurts, Eva A1 - Ruiz, Gustavo R. A1 - Corra, Ugo A1 - Schmid, Jean-Paul A1 - Greco, Eugenio A1 - Davos, Constantinos H. A1 - Edelmann, Frank A1 - Abreu, Ana A1 - Rauch, Bernhard A1 - Ambrosetti, Marco A1 - Braga, Simona S. A1 - Barna, Olga A1 - Beckers, Paul A1 - Bussotti, Maurizio A1 - Fagard, Robert A1 - Faggiano, Pompilio A1 - Garcia-Porrero, Esteban A1 - Kouidi, Evangelia A1 - Lamotte, Michel A1 - Neunhaeuserer, Daniel A1 - Reibis, Rona Katharina A1 - Spruit, Martijn A. A1 - Stettler, Christoph A1 - Takken, Tim A1 - Tonoli, Cajsa A1 - Vigorito, Carlo A1 - Völler, Heinz A1 - Doherty, Patrick T1 - The European Association of Preventive Cardiology Exercise Prescription in Everyday Practice and Rehabilitative Training (EXPERT) tool: A digital training and decision support system for optimized exercise prescription in cardiovascular disease. Concept, definitions and construction methodology JF - European journal of preventive cardiology : the official ESC journal for primary & secondary cardiovascular prevention, rehabilitation and sports cardiology N2 - Background Exercise rehabilitation is highly recommended by current guidelines on prevention of cardiovascular disease, but its implementation is still poor. Many clinicians experience difficulties in prescribing exercise in the presence of different concomitant cardiovascular diseases and risk factors within the same patient. It was aimed to develop a digital training and decision support system for exercise prescription in cardiovascular disease patients in clinical practice: the European Association of Preventive Cardiology Exercise Prescription in Everyday Practice and Rehabilitative Training (EXPERT) tool. Methods EXPERT working group members were requested to define (a) diagnostic criteria for specific cardiovascular diseases, cardiovascular disease risk factors, and other chronic non-cardiovascular conditions, (b) primary goals of exercise intervention, (c) disease-specific prescription of exercise training (intensity, frequency, volume, type, session and programme duration), and (d) exercise training safety advices. The impact of exercise tolerance, common cardiovascular medications and adverse events during exercise testing were further taken into account for optimized exercise prescription. Results Exercise training recommendations and safety advices were formulated for 10 cardiovascular diseases, five cardiovascular disease risk factors (type 1 and 2 diabetes, obesity, hypertension, hypercholesterolaemia), and three common chronic non-cardiovascular conditions (lung and renal failure and sarcopaenia), but also accounted for baseline exercise tolerance, common cardiovascular medications and occurrence of adverse events during exercise testing. An algorithm, supported by an interactive tool, was constructed based on these data. This training and decision support system automatically provides an exercise prescription according to the variables provided. Conclusion This digital training and decision support system may contribute in overcoming barriers in exercise implementation in common cardiovascular diseases. KW - Cardiovascular disease KW - rehabilitation KW - exercise training KW - training and decision support system Y1 - 2017 U6 - https://doi.org/10.1177/2047487317702042 SN - 2047-4873 SN - 2047-4881 VL - 24 SP - 1017 EP - 1031 PB - Sage Publ. CY - London ER - TY - BOOK A1 - Jennek, Julia A1 - Rother, Stefanie A1 - Tosch, Frank A1 - Wendland, Mirko A1 - Kludt, Steffen A1 - Krauskopf, Karsten A1 - Kitschke, Dorothea A1 - Maar, Verena A1 - Knigge, Michel A1 - Gnädig, Susanne A1 - Seidel, Astrid A1 - Siehr, Karl-Heinz A1 - Wienecke, Maik A1 - Günther, Claudia-Susanne A1 - Reitz-Koncebovski, Karen A1 - Klöpping, Peter M. A1 - Kücholl, Denise A1 - Lazarides, Rebecca A1 - Westphal, Andrea A1 - Scherreiks, Lynn A1 - Kuhr, Linda A1 - Wilbert, Jürgen A1 - Gronostaj, Anna A1 - Vock, Miriam A1 - Zaruba, Nicole A1 - Ahlgrimm, Frederik A1 - Link, Jörg-Werner A1 - Körner, Dorothea A1 - Barseghyan, Anahit A1 - Glowinski, Ingrid ED - Jennek, Julia T1 - Professionalisierung in Praxisphasen BT - Ergebnisse der Lehrerbildungsforschung an der Universität Potsdam T3 - Potsdamer Beiträge zur Lehrerbildung und Bildungsforschung N2 - Schulpraktika bilden die zentrale Grundlage der Lehrerbildung in Potsdam. Bereits im Potsdamer Modell der Lehrerbildung (1993) sind sie festgehalten, seit der Integration des Schulpraktikums (Praxissemesters) 2008 absolvieren alle Potsdamer Lehramtsstudierenden fünf Pflichtpraktika. Während die Ziele der Praktika klar beschrieben sind, sind die tatsächlichen Lernerfolge nicht immer klar – ebenso wenig, wie die Begleitung der Praktika aussehen muss, um die Studierenden bestmöglich zu unterstützen. Auch die Integration in weitere Lehrveranstaltungen des Studiums ist ein noch offenes Feld, das weiterer Betrachtung verdient. Die unterschiedliche Ausrichtung der Potsdamer Praktika, Perspektivwechsel im Orientierungs-/Integriertem Eingangspraktikum, Selbstreflektion im Praktikum in pädagogisch-psychologischen Handlungsfeldern, Unterricht als Profession in den Fachdidaktischen Tagespraktika, Anwendung von Diagnostik im psychodiagnostischen Praktikum und die Synthese all dessen im Schulpraktikum, bieten dafür zahlreiche Ansatzpunkte. Schulpraktika sind nicht nur ein zentraler und von Studierenden hoch geschätzter Bestandteil des Studiums, sondern werden auch zunehmend für die Bildungsforschung interessant. Fragen nach der Kompetenzentwicklung, Selbsteinschätzungen und der Entwicklung der Reflexionsfähigkeit von Studierenden stehen dabei ebenso im Fokus wie die Einschätzung der universitären Begleitung und der Einbindung ins weitere Studium. Der vorliegende Band versammelt Studien von Wissenschaftlerinnen und Wissenschaftler der Universität Potsdam, die die fünf Pflichtpraktika im Lehramtsstudium unter unterschiedlichen Blickwinkel beforschen. Besonders hervorzuheben ist, dass die Wissenschaftlerinnen und Wissenschaftler aus unterschiedlichen Disziplinen stammen und somit die Praktika mit verschiedenen Instrumenten und aus unterschiedlichen Blickwinkeln betrachten. Die präsentierten Ergebnisse bilden eine gute Grundlage, um die Praktika in Potsdam und an anderen Standorten weiterzuentwickeln. T3 - Potsdamer Beiträge zur Lehrkräftebildung und Bildungsforschung - 2 KW - Lehrkräftebildung KW - Schulpraktikum KW - Lehramtsstudium KW - Berufspraktische Studien KW - Praxissemester Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-500964 SN - 978-3-86956-508-8 SN - 2626-3556 SN - 2626-4722 IS - 2 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - BOOK A1 - Bauer, Hartmut A1 - Hajasch, Lydia A1 - Lübking, Uwe A1 - Stein, Ursula A1 - Roth, Roland A1 - Sippel, Hanns-Jörg A1 - Bock, Stephanie A1 - Friesecke, Frank A1 - Kleger, Heinz A1 - Vowe, Gerhard A1 - Utz, Stephanie Sophia A1 - Buchmann, Madeleine A1 - Löffler, Roland A1 - Zielske, Johanna ED - Bauer, Hartmut ED - Büchner, Christiane ED - Hajasch, Lydia T1 - Partizipation in der Bürgerkommune T3 - KWI Schriften N2 - Konzepte, nach denen sich die demokratische Mitwirkung der Bürger vornehmlich in Wahlen erschöpft, gehören spätestens seit „Stuttgart 21“ der Vergangenheit an. Indes ist die Bürgerbeteiligung auch jenseits solcher Großprojekte längst zu einem beherrschenden Thema der Zeit herangewachsen. Das gilt zumal für die kommunale Ebene. Dort werden traditionsreiche Partizipationsformen nicht nur intensiv genutzt, sondern zunehmend um neue Beteiligungsvarianten ergänzt und in innovativen Modellprojekten fortentwickelt. Dabei treten zwei Antriebskräfte besonders hervor. Zum einen fordern die Bürger nach den Maximen „Mitmachen, Mitwirken, Mitentscheiden“ deutlich verbesserte Partizipationsmöglichkeiten ein. Zum anderen setzen die Kommunen verstärkt auf bürgerschaftliches Engagement zur Erschließung Ressourcen privater Akteure für die Bereitstellung öffentlicher Leistungen. Übergreifende Perspektive ist die Ausbildung einer Neuen Partizipationskultur in der Bürgerkommune zur Optimierung des Gemeinwohls. Für die kommunale Praxis ist das partizipationsgestützte Miteinander von Verwaltung. Politik und Bürgerschaft in Systementwürfen, Leitbildern, Organisations- und Verfahrensmodellen sowie lokalen Beteiligungsformaten konkretisiert. Doch verbinden sich mit den alten und neuen Ansätzen der Bürgerbeteiligung noch eine ganze Reihe offener Fragen – so etwa nach den rechtlichen Möglichkeiten und Grenzen der neuen kommunalen Beteiligungskultur, nach Erfolgsbedingungen und konkreten Erfahrungen mit der Umsetzung von Partizipationsmodellen. Auf der 21. Fachtagung des Kommunalwissenschaftlichen Instituts (KWI) der Universität Potsdam wurden Schlüsselthemen der Neuen Partizipationskultur in der Bürgerkommune, namentlich der normativen Rahmenbedingungen und politischen Direktiven, Modernisierungsimpulse und Aktivierungsstrategien, Erfolgsbedingungen und spezifische Problemlagen einschließlich der Fallstricke in der Praxis und nicht zuletzt ausgewählter Einsatzfelder mit den dazugehörigen Erfahrungen diskutiert. T3 - KWI-Schriften - 10 KW - kommunale Demokratie KW - kommunale Entscheidungsprozesse KW - Partizipation KW - Partizipationsprozesse KW - Bürgerkommune Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-101601 SN - 978-3-86956-371-8 SN - 1867-951X SN - 1867-9528 IS - 10 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Dahm, Torsten A1 - Krüger, Frank A1 - Essen, Heinz-Hermann A1 - Hensch, Martin T1 - Historic microseismic data and their relation to the wave-climate in the North Atlantic N2 - Microseismic data from observatories in Europe, which have been continuously recorded since about 100 years, contain information on the wave-climate in the North Atlantic. They can potentially be used as additional constraints in high-resolution temporal and spatial reconstructions of the storminess and oceanic waveheights in the past. To resolve spatial patterns data from observatories in different regions are needed. While previous recent studies analyzed only few observatory archives and relatively short time ranges, this is a first attempt to process the whole available data archive from different observatories. We correct and compare smoothed microseismic data from different stations and discuss their correlation and possible use for studies of storminess variability. Microseismic amplitudes at four seismic stations in northern Europe show amplitude peaks in 1920 and 1925, a slow decline in amplitudes till the middle of the 1930's followed by a steady increase of amplitudes till about 1990. From 1990 on microseismic amplitudes decrease. We find a good correlation between the average surface wind velocity in the North Atlantic and microseismic amplitudes at inland stations far away from the coast. Coastal stations are more influenced by local swell and are thus potentially useful to recover regional changes in wind and ocean wavefields with time. The study demonstrates that the analysis of microseismic has the potential to assess climate changes during the last 100 years Y1 - 2005 ER - TY - GEN A1 - Eichler, Sarah A1 - Salzwedel, Annett A1 - Rabe, Sophie A1 - Mueller, Steffen A1 - Mayer, Frank A1 - Wochatz, Monique A1 - Hadzic, Miralem A1 - John, Michael A1 - Wegscheider, Karl A1 - Völler, Heinz T1 - The Effectiveness of Telerehabilitation as a Supplement to Rehabilitation in Patients After Total Knee or Hip Replacement BT - Randomized Controlled Trial T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Background: Telerehabilitation can contribute to the maintenance of successful rehabilitation regardless of location and time. The aim of this study was to investigate a specific three-month interactive telerehabilitation routine regarding its effectiveness in assisting patients with physical functionality and with returning to work compared to typical aftercare. Objective: The aim of the study was to investigate a specific three-month interactive telerehabilitation with regard to effectiveness in functioning and return to work compared to usual aftercare. Methods: From August 2016 to December 2017, 111 patients (mean 54.9 years old; SD 6.8; 54.3% female) with hip or knee replacement were enrolled in the randomized controlled trial. At discharge from inpatient rehabilitation and after three months, their distance in the 6-minute walk test was assessed as the primary endpoint. Other functional parameters, including health related quality of life, pain, and time to return to work, were secondary endpoints. Results: Patients in the intervention group performed telerehabilitation for an average of 55.0 minutes (SD 9.2) per week. Adherence was high, at over 75%, until the 7th week of the three-month intervention phase. Almost all the patients and therapists used the communication options. Both the intervention group (average difference 88.3 m; SD 57.7; P=.95) and the control group (average difference 79.6 m; SD 48.7; P=.95) increased their distance in the 6-minute-walk-test. Improvements in other functional parameters, as well as in quality of life and pain, were achieved in both groups. The higher proportion of working patients in the intervention group (64.6%; P=.01) versus the control group (46.2%) is of note. Conclusions: The effect of the investigated telerehabilitation therapy in patients following knee or hip replacement was equivalent to the usual aftercare in terms of functional testing, quality of life, and pain. Since a significantly higher return-to-work rate could be achieved, this therapy might be a promising supplement to established aftercare. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 589 KW - telerehabilitation KW - home-based KW - total hip replacement KW - total knee replacement KW - exercise therapy KW - aftercare KW - rehabilitation Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-440965 SN - 1866-8364 IS - 589 ER - TY - GEN A1 - Eichler, Sarah A1 - Rabe, Sophie A1 - Salzwedel, Annett A1 - Müller, Steffen A1 - Stoll, Josefine A1 - Tilgner, Nina A1 - John, Michael A1 - Wegschneider, Karl A1 - Mayer, Frank A1 - Völler, Heinz T1 - Effectiveness of an interactive telerehabilitation system with home-based exercise training in patients after total hip or knee replacement BT - Study protocol for a multicenter, superiority, no-blinded randomized controlled trial N2 - Background Total hip or knee replacement is one of the most frequently performed surgical procedures. Physical rehabilitation following total hip or knee replacement is an essential part of the therapy to improve functional outcomes and quality of life. After discharge from inpatient rehabilitation, a subsequent postoperative exercise therapy is needed to maintain functional mobility. Telerehabilitation may be a potential innovative treatment approach. We aim to investigate the superiority of an interactive telerehabilitation intervention for patients after total hip or knee replacement, in comparison to usual care, regarding physical performance, functional mobility, quality of life and pain. Methods/design This is an open, randomized controlled, multicenter superiority study with two prospective arms. One hundred and ten eligible and consenting participants with total knee or hip replacement will be recruited at admission to subsequent inpatient rehabilitation. After comprehensive, 3-week, inpatient rehabilitation, the intervention group performs a 3-month, interactive, home-based exercise training with a telerehabilitation system. For this purpose, the physiotherapist creates an individual training plan out of 38 different strength and balance exercises which were implemented in the system. Data about the quality and frequency of training are transmitted to the physiotherapist for further adjustment. Communication between patient and physiotherapist is possible with the system. The control group receives voluntary, usual aftercare programs. Baseline assessments are investigated after discharge from rehabilitation; final assessments 3 months later. The primary outcome is the difference in improvement between intervention and control group in 6-minute walk distance after 3 months. Secondary outcomes include differences in the Timed Up and Go Test, the Five-Times-Sit-to-Stand Test, the Stair Ascend Test, the Short-Form 36, the Western Ontario and McMaster Universities Osteoarthritis Index, the International Physical Activity Questionnaire, and postural control as well as gait and kinematic parameters of the lower limbs. Baseline-adjusted analysis of covariance models will be used to test for group differences in the primary and secondary endpoints. Discussion We expect the intervention group to benefit from the interactive, home-based exercise training in many respects represented by the study endpoints. If successful, this approach could be used to enhance the access to aftercare programs, especially in structurally weak areas. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 353 KW - Aftercare KW - Exercise therapy KW - Home-based KW - Telerehabilitation KW - Total hip replacement KW - Total knee replacement Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-403702 ER - TY - JOUR A1 - Eichler, Sarah A1 - Salzwedel, Annett A1 - Rabe, Sophie A1 - Mueller, Steffen A1 - Mayer, Frank A1 - Wochatz, Monique A1 - Hadzic, Miralem A1 - John, Michael A1 - Wegscheider, Karl A1 - Völler, Heinz T1 - The Effectiveness of Telerehabilitation as a Supplement to Rehabilitation in Patients After Total Knee or Hip Replacement BT - Randomized Controlled Trial JF - JMIR Rehabilitation and Assistive Technologies N2 - Background: Telerehabilitation can contribute to the maintenance of successful rehabilitation regardless of location and time. The aim of this study was to investigate a specific three-month interactive telerehabilitation routine regarding its effectiveness in assisting patients with physical functionality and with returning to work compared to typical aftercare. Objective: The aim of the study was to investigate a specific three-month interactive telerehabilitation with regard to effectiveness in functioning and return to work compared to usual aftercare. Methods: From August 2016 to December 2017, 111 patients (mean 54.9 years old; SD 6.8; 54.3% female) with hip or knee replacement were enrolled in the randomized controlled trial. At discharge from inpatient rehabilitation and after three months, their distance in the 6-minute walk test was assessed as the primary endpoint. Other functional parameters, including health related quality of life, pain, and time to return to work, were secondary endpoints. Results: Patients in the intervention group performed telerehabilitation for an average of 55.0 minutes (SD 9.2) per week. Adherence was high, at over 75%, until the 7th week of the three-month intervention phase. Almost all the patients and therapists used the communication options. Both the intervention group (average difference 88.3 m; SD 57.7; P=.95) and the control group (average difference 79.6 m; SD 48.7; P=.95) increased their distance in the 6-minute-walk-test. Improvements in other functional parameters, as well as in quality of life and pain, were achieved in both groups. The higher proportion of working patients in the intervention group (64.6%; P=.01) versus the control group (46.2%) is of note. Conclusions: The effect of the investigated telerehabilitation therapy in patients following knee or hip replacement was equivalent to the usual aftercare in terms of functional testing, quality of life, and pain. Since a significantly higher return-to-work rate could be achieved, this therapy might be a promising supplement to established aftercare. KW - telerehabilitation KW - home-based KW - total hip replacement KW - total knee replacement KW - exercise therapy KW - aftercare KW - rehabilitation Y1 - 2019 U6 - https://doi.org/10.2196/14236 SN - 2369-2529 VL - 6 IS - 2 PB - jmir rehab CY - Toronto ER - TY - JOUR A1 - Hoffmann, Sebastian T. A1 - Jaiser, Frank A1 - Hayer, Anna A1 - Baessler, Heinz A1 - Unger, Thomas A1 - Athanasopoulos, Stavros A1 - Neher, Dieter A1 - Koehler, Anna T1 - How Do Disorder, Reorganization, and Localization Influence the Hole Mobility in Conjugated Copolymers? JF - JOURNAL OF THE AMERICAN CHEMICAL SOCIETY N2 - In order to unravel the intricate interplay between disorder effects, molecular reorganization, and charge carrier localization, a comprehensive study was conducted on hole transport in a series of conjugated alternating phenanthrene indenofluorene copolymers. Each polymer in the series contained one further comonomer comprising monoamines, diamines, or amine-free structures, whose influence on the electronic, optical, and charge transport properties was studied. The series covered a wide range of highest occupied molecular orbital (HOMO) energies as determined by cyclovoltammetry. The mobility, inferred from time-of-flight (ToF) experiments as a function of temperature and electric field, was found to depend exponentially on the HOMO energy. Since possible origins for this effect include energetic disorder, polaronic effects, and wave function localization, the relevant parameters were determined using a range of methods. Disorder and molecular reorganization were established first by an analysis of absorption and emission measurements and second by an analysis of the ToF measurements. In addition, density functional theory calculations were carried out to determine how localized or delocalized holes on a polymer chain are and to compare calculated reorganization energies with those that have been inferred from optical spectra. In summary, we conclude that molecular reorganization has little effect on the hole mobility in this system while both disorder effects and hole localization in systems with low-lying HOMOs are predominant. In particular, as the energetic disorder is comparable for the copolymers, the absolute value of the hole mobility at room temperature is determined by the hole localization associated with the triarylamine moieties. Y1 - 2013 U6 - https://doi.org/10.1021/ja308820j SN - 0002-7863 VL - 135 IS - 5 SP - 1772 EP - 1782 PB - AMER CHEMICAL SOC CY - WASHINGTON ER - TY - JOUR A1 - Wochatz, Monique A1 - Tilgner, Nina A1 - Mueller, Steffen A1 - Rabe, Sophie A1 - Eichler, Sarah A1 - John, Michael A1 - Völler, Heinz A1 - Mayer, Frank T1 - Reliability and validity of the Kinect V2 for the assessment of lower extremity rehabilitation exercises JF - Gait & posture N2 - Research question: The purpose of this study was to evaluate the test-retest reliability of lower extremity kinematics during squat, hip abduction and lunge exercises captured by the Kinect and to evaluate the agreement to a reference 3D camera-based motion system. Methods: Twenty-one healthy individuals performed five repetitions of each lower limb exercise on two different days. Movements were simultaneously assessed by the Kinect and the reference 3D motion system. Joint angles and positions of the lower limb were calculated for sagittal and frontal plane. For the inter-session reliability and the agreement between the two systems standard error of measurement (SEM), bias with limits of agreement (LoA) and Pearson Correlation Coefficient (r) were calculated. Results: Parameters indicated varying reliability for the assessed joint angles and positions and decreasing reliability with increasing task complexity. Across all exercises, measurement deviations were shown especially for small movement amplitudes. Variability was acceptable for joint angles and positions during the squat, partially acceptable during the hip abduction and predominately inacceptable during the lunge. The agreement between systems was characterized by systematic errors. Overestimations by the Kinect were apparent for hip flexion during the squat and hip abduction/adduction during the hip abduction exercise as well as for the knee positions during the lunge. Knee and hip flexion during hip abduction and lunge were underestimated by the Kinect. Significance: The Kinect system can reliably assess lower limb joint angles and positions during simple exercises. The validity of the system is however restricted. An application in the field of early orthopedic rehabilitation without further development of post-processing techniques seems so far limited. KW - Reproducibility KW - Agreement KW - Markerless motion capture system KW - Telerehabilitation Y1 - 2018 U6 - https://doi.org/10.1016/j.gaitpost.2019.03.020 SN - 0966-6362 SN - 1879-2219 VL - 70 SP - 330 EP - 335 PB - Elsevier CY - Clare ER - TY - JOUR A1 - Eichler, Sarah A1 - Rabe, Sophie A1 - Salzwedel, Annett A1 - Mueller, Steffen A1 - Stoll, Josefine A1 - Tilgner, Nina A1 - John, Michael A1 - Wegscheider, Karl A1 - Mayer, Frank A1 - Völler, Heinz T1 - Effectiveness of an interactive telerehabilitation system with home-based exercise training in patients after total hip or knee replacement: study protocol for a multicenter, superiority, no-blinded randomized controlled trial JF - Trials N2 - Background: Total hip or knee replacement is one of the most frequently performed surgical procedures. Physical rehabilitation following total hip or knee replacement is an essential part of the therapy to improve functional outcomes and quality of life. After discharge from inpatient rehabilitation, a subsequent postoperative exercise therapy is needed to maintain functional mobility. Telerehabilitation may be a potential innovative treatment approach. We aim to investigate the superiority of an interactive telerehabilitation intervention for patients after total hip or knee replacement, in comparison to usual care, regarding physical performance, functional mobility, quality of life and pain. Methods/design: This is an open, randomized controlled, multicenter superiority study with two prospective arms. One hundred and ten eligible and consenting participants with total knee or hip replacement will be recruited at admission to subsequent inpatient rehabilitation. After comprehensive, 3-week, inpatient rehabilitation, the intervention group performs a 3-month, interactive, home-based exercise training with a telerehabilitation system. For this purpose, the physiotherapist creates an individual training plan out of 38 different strength and balance exercises which were implemented in the system. Data about the quality and frequency of training are transmitted to the physiotherapist for further adjustment. Communication between patient and physiotherapist is possible with the system. The control group receives voluntary, usual aftercare programs. Baseline assessments are investigated after discharge from rehabilitation; final assessments 3 months later. The primary outcome is the difference in improvement between intervention and control group in 6-minute walk distance after 3 months. Secondary outcomes include differences in the Timed Up and Go Test, the Five-Times-Sit-to-Stand Test, the Stair Ascend Test, the Short-Form 36, the Western Ontario and McMaster Universities Osteoarthritis Index, the International Physical Activity Questionnaire, and postural control as well as gait and kinematic parameters of the lower limbs. Baseline-adjusted analysis of covariance models will be used to test for group differences in the primary and secondary endpoints. Discussion: We expect the intervention group to benefit from the interactive, home-based exercise training in many respects represented by the study endpoints. If successful, this approach could be used to enhance the access to aftercare programs, especially in structurally weak areas. KW - Telerehabilitation KW - Home-based KW - Total hip replacement KW - Total knee replacement KW - Exercise therapy KW - Aftercare Y1 - 2017 U6 - https://doi.org/10.1186/s13063-017-2173-3 SN - 1745-6215 VL - 18 PB - BioMed Central CY - London ER - TY - JOUR A1 - Eichler, Sarah A1 - Rabe, Sophie A1 - Salzwedel, Annett A1 - Müller, Steffen A1 - Stoll, Josefine A1 - Tilgner, Nina A1 - John, Michael A1 - Wegschneider, Karl A1 - Mayer, Frank A1 - Völler, Heinz T1 - Effectiveness of an interactive telerehabilitation system with home-based exercise training in patients after total hip or knee replacement BT - Study protocol for a multicenter, superiority, no-blinded randomized controlled trial JF - Trials N2 - Background Total hip or knee replacement is one of the most frequently performed surgical procedures. Physical rehabilitation following total hip or knee replacement is an essential part of the therapy to improve functional outcomes and quality of life. After discharge from inpatient rehabilitation, a subsequent postoperative exercise therapy is needed to maintain functional mobility. Telerehabilitation may be a potential innovative treatment approach. We aim to investigate the superiority of an interactive telerehabilitation intervention for patients after total hip or knee replacement, in comparison to usual care, regarding physical performance, functional mobility, quality of life and pain. Methods/design This is an open, randomized controlled, multicenter superiority study with two prospective arms. One hundred and ten eligible and consenting participants with total knee or hip replacement will be recruited at admission to subsequent inpatient rehabilitation. After comprehensive, 3-week, inpatient rehabilitation, the intervention group performs a 3-month, interactive, home-based exercise training with a telerehabilitation system. For this purpose, the physiotherapist creates an individual training plan out of 38 different strength and balance exercises which were implemented in the system. Data about the quality and frequency of training are transmitted to the physiotherapist for further adjustment. Communication between patient and physiotherapist is possible with the system. The control group receives voluntary, usual aftercare programs. Baseline assessments are investigated after discharge from rehabilitation; final assessments 3 months later. The primary outcome is the difference in improvement between intervention and control group in 6-minute walk distance after 3 months. Secondary outcomes include differences in the Timed Up and Go Test, the Five-Times-Sit-to-Stand Test, the Stair Ascend Test, the Short-Form 36, the Western Ontario and McMaster Universities Osteoarthritis Index, the International Physical Activity Questionnaire, and postural control as well as gait and kinematic parameters of the lower limbs. Baseline-adjusted analysis of covariance models will be used to test for group differences in the primary and secondary endpoints. Discussion We expect the intervention group to benefit from the interactive, home-based exercise training in many respects represented by the study endpoints. If successful, this approach could be used to enhance the access to aftercare programs, especially in structurally weak areas. KW - Telerehabilitation KW - Home-based KW - Total hip replacement KW - Total knee replacement KW - Exercise therapy KW - Aftercare Y1 - 2017 U6 - https://doi.org/10.1186/s13063-017-2173-3 SN - 1745-6215 VL - 18 SP - 1 EP - 7 PB - BioMed Central CY - London ER - TY - GEN A1 - Schraplau, Anne A1 - Block, Andrea A1 - Häusler, Andreas A1 - Wippert, Pia-Maria A1 - Rapp, Michael A. A1 - Völler, Heinz A1 - Bonaventura, Klaus A1 - Mayer, Frank T1 - Mobile diagnostics and consultation for the prevention of the metabolic syndrome and its secondary diseases in Brandenburg—study protocol of a regional prospective cohort study: the Mobile Brandenburg Cohort T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Background The metabolic syndrome (MetS) is a risk cluster for a number of secondary diseases. The implementation of prevention programs requires early detection of individuals at risk. However, access to health care providers is limited in structurally weak regions. Brandenburg, a rural federal state in Germany, has an especially high MetS prevalence and disease burden. This study aims to validate and test the feasibility of a setup for mobile diagnostics of MetS and its secondary diseases, to evaluate the MetS prevalence and its association with moderating factors in Brandenburg and to identify new ways of early prevention, while establishing a “Mobile Brandenburg Cohort” to reveal new causes and risk factors for MetS. Methods In a pilot study, setups for mobile diagnostics of MetS and secondary diseases will be developed and validated. A van will be equipped as an examination room using point-of-care blood analyzers and by mobilizing standard methods. In study part A, these mobile diagnostic units will be placed at different locations in Brandenburg to locally recruit 5000 participants aged 40-70 years. They will be examined for MetS and advice on nutrition and physical activity will be provided. Questionnaires will be used to evaluate sociodemographics, stress perception, and physical activity. In study part B, participants with MetS, but without known secondary diseases, will receive a detailed mobile medical examination, including MetS diagnostics, medical history, clinical examinations, and instrumental diagnostics for internal, cardiovascular, musculoskeletal, and cognitive disorders. Participants will receive advice on nutrition and an exercise program will be demonstrated on site. People unable to participate in these mobile examinations will be interviewed by telephone. If necessary, participants will be referred to general practitioners for further diagnosis. Discussion The mobile diagnostics approach enables early detection of individuals at risk, and their targeted referral to local health care providers. Evaluation of the MetS prevalence, its relation to risk-increasing factors, and the “Mobile Brandenburg Cohort” create a unique database for further longitudinal studies on the implementation of home-based prevention programs to reduce mortality, especially in rural regions. Trial registration German Clinical Trials Register, DRKS00022764; registered 07 October 2020—retrospectively registered. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 759 KW - Metabolic syndrome KW - Mobile diagnostics KW - Prevention KW - Nutrition KW - Physical activity KW - Rural health Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-549506 SN - 1866-8364 SP - 1 EP - 11 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Schraplau, Anne A1 - Block, Andrea A1 - Häusler, Andreas A1 - Wippert, Pia-Maria A1 - Rapp, Michael A. A1 - Völler, Heinz A1 - Bonaventura, Klaus A1 - Mayer, Frank T1 - Mobile diagnostics and consultation for the prevention of the metabolic syndrome and its secondary diseases in Brandenburg—study protocol of a regional prospective cohort study BT - the Mobile Brandenburg Cohort JF - Pilot and Feasibility Studies N2 - Background The metabolic syndrome (MetS) is a risk cluster for a number of secondary diseases. The implementation of prevention programs requires early detection of individuals at risk. However, access to health care providers is limited in structurally weak regions. Brandenburg, a rural federal state in Germany, has an especially high MetS prevalence and disease burden. This study aims to validate and test the feasibility of a setup for mobile diagnostics of MetS and its secondary diseases, to evaluate the MetS prevalence and its association with moderating factors in Brandenburg and to identify new ways of early prevention, while establishing a “Mobile Brandenburg Cohort” to reveal new causes and risk factors for MetS. Methods In a pilot study, setups for mobile diagnostics of MetS and secondary diseases will be developed and validated. A van will be equipped as an examination room using point-of-care blood analyzers and by mobilizing standard methods. In study part A, these mobile diagnostic units will be placed at different locations in Brandenburg to locally recruit 5000 participants aged 40-70 years. They will be examined for MetS and advice on nutrition and physical activity will be provided. Questionnaires will be used to evaluate sociodemographics, stress perception, and physical activity. In study part B, participants with MetS, but without known secondary diseases, will receive a detailed mobile medical examination, including MetS diagnostics, medical history, clinical examinations, and instrumental diagnostics for internal, cardiovascular, musculoskeletal, and cognitive disorders. Participants will receive advice on nutrition and an exercise program will be demonstrated on site. People unable to participate in these mobile examinations will be interviewed by telephone. If necessary, participants will be referred to general practitioners for further diagnosis. Discussion The mobile diagnostics approach enables early detection of individuals at risk, and their targeted referral to local health care providers. Evaluation of the MetS prevalence, its relation to risk-increasing factors, and the “Mobile Brandenburg Cohort” create a unique database for further longitudinal studies on the implementation of home-based prevention programs to reduce mortality, especially in rural regions. Trial registration German Clinical Trials Register, DRKS00022764; registered 07 October 2020—retrospectively registered. KW - Metabolic syndrome KW - Mobile diagnostics KW - Prevention KW - Nutrition KW - Physical activity KW - Rural health Y1 - 2021 U6 - https://doi.org/10.1186/s40814-021-00898-w SN - 2055-5784 VL - 7 SP - 1 EP - 11 PB - BioMed Central (Springer Nature) CY - London ER - TY - JOUR A1 - Sebold, Miriam A1 - Nebe, Stephan A1 - Garbusow, Maria A1 - Guggenmos, Matthias A1 - Schad, Daniel A1 - Beck, Anne A1 - Kuitunen-Paul, Sören A1 - Sommer, Christian A1 - Frank, Robin A1 - Neu, Peter A1 - Zimmermann, Ulrich S. A1 - Rapp, Michael A. A1 - Smolka, Michael N. A1 - Huys, Quentin J. M. A1 - Schlagenhauf, Florian A1 - Heinz, Andreas T1 - When Habits Are Dangerous: Alcohol Expectancies and Habitual Decision Making Predict Relapse in Alcohol Dependence JF - Biological psychiatry : a journal of psychiatric neuroscience and therapeutics ; a publication of the Society of Biological Psychiatry N2 - BACKGROUND: Addiction is supposedly characterized by a shift from goal-directed to habitual decision making, thus facilitating automatic drug intake. The two-step task allows distinguishing between these mechanisms by computationally modeling goal-directed and habitual behavior as model-based and model-free control. In addicted patients, decision making may also strongly depend upon drug-associated expectations. Therefore, we investigated model-based versus model-free decision making and its neural correlates as well as alcohol expectancies in alcohol-dependent patients and healthy controls and assessed treatment outcome in patients. METHODS: Ninety detoxified, medication-free, alcohol-dependent patients and 96 age-and gender-matched control subjects underwent functional magnetic resonance imaging during the two-step task. Alcohol expectancies were measured with the Alcohol Expectancy Questionnaire. Over a follow-up period of 48 weeks, 37 patients remained abstinent and 53 patients relapsed as indicated by the Alcohol Timeline Followback method. RESULTS: Patients who relapsed displayed reduced medial prefrontal cortex activation during model-based decision making. Furthermore, high alcohol expectancies were associated with low model-based control in relapsers, while the opposite was observed in abstainers and healthy control subjects. However, reduced model-based control per se was not associated with subsequent relapse. CONCLUSIONS: These findings suggest that poor treatment outcome in alcohol dependence does not simply result from a shift from model-based to model-free control but is instead dependent on the interaction between high drug expectancies and low model-based decision making. Reduced model-based medial prefrontal cortex signatures in those who relapse point to a neural correlate of relapse risk. These observations suggest that therapeutic interventions should target subjective alcohol expectancies. KW - Alcohol dependence KW - Alcohol expectancy KW - Goal-directed control KW - Medial prefrontal cortex KW - Reinforcement learning KW - Treatment outcome Y1 - 2017 U6 - https://doi.org/10.1016/j.biopsych.2017.04.019 SN - 0006-3223 SN - 1873-2402 VL - 82 SP - 847 EP - 856 PB - Elsevier CY - New York ER - TY - JOUR A1 - Schulze-Makuch, Dirk A1 - Wagner, Dirk A1 - Kounaves, Samuel P. A1 - Mangelsdorf, Kai A1 - Devine, Kevin G. A1 - de Vera, Jean-Pierre A1 - Schmitt-Kopplin, Philippe A1 - Grossart, Hans-Peter A1 - Parro, Victor A1 - Kaupenjohann, Martin A1 - Galy, Albert A1 - Schneider, Beate A1 - Airo, Alessandro A1 - Froesler, Jan A1 - Davila, Alfonso F. A1 - Arens, Felix L. A1 - Caceres, Luis A1 - Cornejo, Francisco Solis A1 - Carrizo, Daniel A1 - Dartnell, Lewis A1 - DiRuggiero, Jocelyne A1 - Flury, Markus A1 - Ganzert, Lars A1 - Gessner, Mark O. A1 - Grathwohl, Peter A1 - Guan, Lisa A1 - Heinz, Jacob A1 - Hess, Matthias A1 - Keppler, Frank A1 - Maus, Deborah A1 - McKay, Christopher P. A1 - Meckenstock, Rainer U. A1 - Montgomery, Wren A1 - Oberlin, Elizabeth A. A1 - Probst, Alexander J. A1 - Saenz, Johan S. A1 - Sattler, Tobias A1 - Schirmack, Janosch A1 - Sephton, Mark A. A1 - Schloter, Michael A1 - Uhl, Jenny A1 - Valenzuela, Bernardita A1 - Vestergaard, Gisle A1 - Woermer, Lars A1 - Zamorano, Pedro T1 - Transitory microbial habitat in the hyperarid Atacama Desert JF - Proceedings of the National Academy of Sciences of the United States of America KW - habitat KW - aridity KW - microbial activity KW - biomarker KW - Mars Y1 - 2018 U6 - https://doi.org/10.1073/pnas.1714341115 SN - 0027-8424 VL - 115 IS - 11 SP - 2670 EP - 2675 PB - National Acad. of Sciences CY - Washington ER -