TY  - JOUR
A1  - Kroke, Anja
A1  - Schmidt, Annemarie
A1  - Amini, Anna M.
A1  - Kalotai, Nicole
A1  - Lehmann, Andreas
A1  - Haardt, Julia
A1  - Bauer, Jürgen M.
A1  - Bischoff-Ferrari, Heike A.
A1  - Boeing, Heiner
A1  - Egert, Sarah
A1  - Ellinger, Sabine
A1  - Kühn, Tilman
A1  - Louis, Sandrine
A1  - Lorkowski, Stefan
A1  - Nimptsch, Katharina
A1  - Remer, Thomas
A1  - Schulze, Matthias B.
A1  - Siener, Roswitha
A1  - Stangl, Gabriele
A1  - Volkert, Dorothee
A1  - Zittermann, Armin
A1  - Buyken, Anette E.
A1  - Watzl, Bernhard
A1  - Schwingshackl, Lukas
T1  - Dietary protein intake and health-related outcomes: a methodological protocol for the evidence evaluation and the outline of an evidence to decision framework underlying the evidence-based guideline of the German Nutrition Society
JF  - European journal of nutrition
N2  - Purpose: The present work aimed to delineate (i) a revised protocol according to recent methodological developments in evidence generation, to (ii) describe its interpretation, the assessment of the overall certainty of evidence and to (iii) outline an Evidence to Decision framework for deriving an evidence-based guideline on quantitative and qualitative aspects of dietary protein intake. Methods A methodological protocol to systematically investigate the association between dietary protein intake and several health outcomes and for deriving dietary protein intake recommendations for the primary prevention of various non-communicable diseases in the general adult population was developed. Results The developed methodological protocol relies on umbrella reviews including systematic reviews with or without meta-analyses. Systematic literature searches in three databases will be performed for each health-related outcome. The methodological quality of all selected systematic reviews will be evaluated using a modified version of AMSTAR 2, and the outcome-specific certainty of evidence for systematic reviews with or without meta-analysis will be assessed with NutriGrade. The general outline of the Evidence to Decision framework foresees that recommendations in the derived guideline will be given based on the overall certainty of evidence as well as on additional criteria such as sustainability. Conclusion The methodological protocol permits a systematic evaluation of published systematic reviews on dietary protein intake and its association with selected health-related outcomes. An Evidence to Decision framework will be the basis for the overall conclusions and the resulting recommendations for dietary protein intake.
KW  - Evidence-based guideline
KW  - Protein intake
KW  - Method
KW  - Prevention
KW  - Nutrition-related diseases
Y1  - 2022
U6  - https://doi.org/10.1007/s00394-021-02789-5
SN  - 1436-6207
SN  - 1436-6215
VL  - 61
IS  - 4
SP  - 2091
EP  - 2101
PB  - Springer Nature
CY  - Heidelberg
ER  -