TY  - JOUR
A1  - Beerenwinkel, Niko
A1  - Sing, Tobias
A1  - Lengauer, Thomas
A1  - Rahnenfuhrer, Joerg
A1  - Roomp, Kirsten
A1  - Savenkov, Igor
A1  - Fischer, Roman
A1  - Hoffmann, Daniel
A1  - Selbig, Joachim
A1  - Korn, Klaus
A1  - Walter, Hauke
A1  - Berg, Thomas
A1  - Braun, Patrick
A1  - Faetkenheuer, Gerd
A1  - Oette, Mark
A1  - Rockstroh, Juergen
A1  - Kupfer, Bernd
A1  - Kaiser, Rolf
A1  - Daeumer, Martin
T1  - Computational methods for the design of effective therapies against drug resistant HIV strains
N2  - The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data
Y1  - 2005
ER  - 
TY  - JOUR
A1  - Trauth, Martin H.
A1  - Asrat, Asfawossen
A1  - Düsing, Walter
A1  - Foerster, Verena
A1  - Krämer, K. Hauke
A1  - Marwan, Norbert
A1  - Maslin, Mark A.
A1  - Schäbitz, Frank
T1  - Classifying past climate change in the Chew Bahir basin, southern Ethiopia, using recurrence quantification analysis
JF  - Climate dynamics : observational, theoretical and computational research on the climate system
N2  - The Chew Bahir Drilling Project (CBDP) aims to test possible linkages between climate and evolution in Africa through the analysis of sediment cores that have recorded environmental changes in the Chew Bahir basin. In this statistical project we consider the Chew Bahir palaeolake to be a dynamical system consisting of interactions between its different components, such as the waterbody, the sediment beneath lake, and the organisms living within and around the lake. Recurrence is a common feature of such dynamical systems, with recurring patterns in the state of the system reflecting typical influences. Identifying and defining these influences contributes significantly to our understanding of the dynamics of the system. Different recurring changes in precipitation, evaporation, and wind speed in the Chew Bahir basin could result in similar (but not identical) conditions in the lake (e.g., depth and area of the lake, alkalinity and salinity of the lake water, species assemblages in the water body, and diagenesis in the sediments). Recurrence plots (RPs) are graphic displays of such recurring states within a system. Measures of complexity were subsequently introduced to complement the visual inspection of recurrence plots, and provide quantitative descriptions for use in recurrence quantification analysis (RQA). We present and discuss herein results from an RQA on the environmental record from six short (< 17 m) sediment cores collected during the CBDP, spanning the last 45 kyrs. The different types of variability and transitions in these records were classified to improve our understanding of the response of the biosphere to climate change, and especially the response of humans in the area.
KW  - Paleoclimate dynamics
KW  - Eastern Africa
KW  - Pleistocene
KW  - Holocene
KW  - Time-series analysis
KW  - Recurrence plot
Y1  - 2019
U6  - https://doi.org/10.1007/s00382-019-04641-3
SN  - 0930-7575
SN  - 1432-0894
VL  - 53
IS  - 5-6
SP  - 2557
EP  - 2572
PB  - Springer
CY  - New York
ER  -