TY - JOUR A1 - Schubert, Dieter A1 - Schluckebier, Gerd A1 - Backmann, Jan A1 - Granzien, Joachim A1 - Kisker, Caroline A1 - Choe, Hui-Woog A1 - Hahn, Ulrich A1 - Pfeil, Wolfgang A1 - Saenger, Wolfram T1 - X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59Tyr in ribonuclease T1 Y1 - 1994 ER - TY - JOUR A1 - Kosmella, Sabine A1 - Venus, Jane A1 - Hahn, Jennifer A1 - Prietzel, Claudia Christina A1 - Koetz, Joachim T1 - Low-temperature synthesis of polyethyleneimine-entrapped CdS quantum dots JF - Chemical physics letters N2 - This Letter is focused on the one-pot formation of CdS nanoparticles in aqueous medium in presence of polyethyleneimine (PEI). Quantum dots can be obtained by adding a pre-cooled aqueous Na2S solution to a pre-cooled aqueous CdCl2 solution dropwise in presence of PEI. Field flow fractionation in combination with TEM experiments show a time dependent agglomeration of individual quantum dots from 1.6 nm up to 3.2 nm in size. The hyperbranched PEI of moderate molar mass (>20000 g/mol) is an excellent polymer to prevent a further increase of the particle size. Therefore, stable fluorescent PEI-capped CdS quantum dots are available. Y1 - 2014 U6 - https://doi.org/10.1016/j.cplett.2013.12.019 SN - 0009-2614 SN - 1873-4448 VL - 592 SP - 114 EP - 119 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Koebnick, Corinna A1 - Plank-Habibi, S. A1 - Wirsam, B. A1 - Gruendel, Sindy A1 - Hahn, A. A1 - Meyer-Kleine, C. A1 - Leitzmann, C. A1 - Zunft, Hans-Joachim Franz T1 - Double-blind, randomized feedback control fails to improve the hypocholesterolemic effect of a plant-based low- fat diet in patients with moderately elevated total cholesterol levels N2 - Objective: To determine whether the cholesterol-lowering effect of a plant-based low-fat diet can be improved by a flexible control design that controls the extent of fat reduction based on the individual response of blood cholesterol. Design: Randomized, double-blind intervention study. Setting: A hotel in Prerow, Germany. Subjects: A total of 32 participants ( 21 female and 11 male participants) with total cholesterol level >5.7 mmol/l. Intervention: The control group consumed a plant-based low-fat diet with constantly 20% of energy as fat; the intervention group received a diet with either 20 or 15% of energy as fat, depending on the serum cholesterol response of the preceding week. A flexible control design based on the individual cholesterol response during a run-in period of 1 week was used within a low-fat intervention. Results: During the run-in period, the consumption of a plant-based low-fat diet led to a reduction in total cholesterol by 18 +/- 6 mmol/l ( P<0.001), in LDL cholesterol by 19 +/- 9 mmol/l ( P<0.001) and triglycerides by 13 +/- 3 mmol/l ( P<0.001). During the feedback control period, an additional reduction in total cholesterol by 13 +/- 8 ( P<0.001) and in LDL cholesterol by 17 +/- 11 (P<0.001) was observed compared to 15715 and 7718 in the control group. The effect of an additional feedback control was only marginal and not statistically significant compared to the effect of the low-fat diet alone. Conclusions: On a level of fat intake already reduced to 20% of energy, the use of a feedback control to adapt the fat content of the diet depending on the individual serum cholesterol response was not more effective in reducing blood cholesterol levels than a plant-based low-fat diet alone. Sponsorship: Institute of Micro-Ecology, Herborn; the Stoll VITA Foundation, Waldshut; ALBAT+WIRSAM Software, Linden; Reformhaus Technical College, Oberstedten; Kolln Flocken Werke, Elmshorn, all in Germany Y1 - 2004 ER -