TY - JOUR A1 - Goebel, Ronald A1 - Hesemann, Peter A1 - Weber, Jens A1 - Moeller, Eléonore A1 - Friedrich, Alwin A1 - Beuermann, Sabine A1 - Taubert, Andreas T1 - Surprisingly high, bulk liquid-like mobility of silica-confined ionic liquids N2 - Mesoporous silica monoliths were prepared by the sol - gel technique and. lled with 1-ethyl-3-methyl imidazolium [Emim]-X (X = dicyanamide [N(CN)(2)], ethyl sulfate [EtSO4], thiocyanate [SCN], and triflate [TfO]) ionic liquids (ILs) using a methanol-IL exchange technique. The structure and behavior of the ILs inside the silica monoliths were studied using X-ray scattering, nitrogen sorption, IR spectroscopy, solid-state NMR, and thermal analysis. DSC finds shifts in both the glass transition temperature and melting points (where applicable) of the ILs. Glass transition and melting occur well below room temperature. There is thus no conflict with the NMR and IR data, which show that the ILs are as mobile at room temperature as the bulk (not confined) ILs. The very narrow line widths of the NMR spectra suggest that the ILs in our materials have the highest mobility reported for confined ILs so far. As a result, our data suggest that it is possible to generate IL/silica hybrid materials (ionogels) with bulk-like properties of the IL. This could be interesting for applications in, e.g., the solar cell or membrane fields. Y1 - 2009 UR - http://xlink.rsc.org/jumptojournal.cfm?journal_code=CP U6 - https://doi.org/10.1039/B821833a SN - 1463-9076 ER - TY - JOUR A1 - Goebel, Ronald A1 - Hesemann, Peter A1 - Friedrich, Alwin A1 - Rothe, Regina A1 - Schlaad, Helmut A1 - Taubert, Andreas T1 - Modular thiol-ene chemistry approach towards mesoporous silica monoliths with organically modified pore walls JF - Chemistry - a European journal N2 - The surface modification of mesoporous silica monoliths through thiol-ene chemistry is reported. First, mesoporous silica monoliths with vinyl, allyl, and thiol groups were synthesized through a sol-gel hydrolysis-poly-condensation reaction from tetramethyl orthosilicate (TMOS) and vinyltriethoxysilane, allyltriethoxysilane, and (3-mercaptopropyl) trimethoxysilane, respectively. By variation of the molar ratio of the comonomers TMOS and functional silane, mesoporous silica objects containing different amounts of vinyl, allyl, and thiol groups were obtained. These intermediates can subsequently be derivatized through radical photoaddition reactions either with a thiol or an olefin, depending on the initial pore wall functionality, to yield silica monoliths with different pore-wall chemistries. Nitrogen sorption, small-angle X-ray scattering, solid-state NMR spectroscopy, elemental analysis, thermogravimetric analysis, and redox titration demonstrate that the synthetic pathway influences the morphology and pore characteristics of the resulting monoliths and also plays a significant role in the efficiency of functionalization. Moreover, the different reactivity of the vinyl and allyl groups on the pore wall affects the addition reaction, and hence, the degree of the pore-wall functionalization. This report demonstrates that thiol-ene photoaddition reactions are a versatile platform for the generation of a large variety of organically modified silica monoliths with different pore surfaces. KW - mesoporous materials KW - photochemistry KW - sol-gel processes KW - surface chemistry Y1 - 2014 U6 - https://doi.org/10.1002/chem.201403982 SN - 0947-6539 SN - 1521-3765 VL - 20 IS - 52 SP - 17579 EP - 17589 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Günther, Oliver A1 - Mangelsdorf, Birgit A1 - Mitzner, Rolf A1 - Loschelder, Wolfgang A1 - Peter, Andreas A1 - Eckert, Barbara A1 - Mikelskis, Helmut A1 - Klein, Alfred A1 - Kirsch, Bärbel A1 - Edelstein, Wolfgang A1 - Thomas, Grünewald A1 - Thomas, Pösl A1 - Wagner, Dieter A1 - Winskowski, Friedrich A1 - Schad, Martina A1 - Frey, Anne A1 - Bickenbach, Wulf A1 - Madani, Roya A1 - Olaka, Lydia T1 - Portal alumni T2 - Das Ehemaligen-Magazin der Universität Potsdam N2 - Das zurückliegende Jahr stand an der Universität Potsdam auch im Zeichen des zwanzigjährigen Jubiläums der Hochschule. Am 15. Juli 1991, wurde sie gegründet und während einer Festwoche feierten Professorinnen und Professoren, Mitarbeiterinnen, Mitarbeiter und Studierende dieses Jubiläum gebührend. Seit der Gründung der größten brandenburgischen Hochschule sind wissenschaftliches Renommee, Ansehen und Attraktivität stetig gewachsen. Gerade in den letzten Jahren hat sie ihr Profil geschärft. Vor allem die Kognitions-, die Geo- und Biowissenschaften sind hier zu nennen. Aber auch die Lehrerbildung besitzt einen hohen Stellenwert. International anerkannte Forschungsbereiche, Wissenschaftspreise, eine erfolgreiche Drittmittelbilanz und nicht zuletzt die bauliche Entwicklung an allen drei Standorten sind sichtbare Indikatoren für die erfolgreiche Entwicklung, die die Universität Potsdam in den letzten zwei Jahrzehnten durchlaufen hat. Die drei ehemaligen Präsidenten sowie verschiedene andere Protagonisten werfen in dieser Ausgabe der Portal Alumni einen Blick auf unterschiedliche Aspekte der zurückliegenden Entwicklung der Universität. Vom Erfolg der Universität zeugt auch die wachsende Zahl der Absolventinnen und Absolventen, die die Universität verlassen. Portal Alumni stellt in der vorliegenden Ausgabe deshalb Absolventen und deren universitäre und berufliche Lebenswege genauer vor und lässt damit zugleich kaleidoskopartig 20 Jahre Studium an der Universität Potsdam Revue passieren. T3 - Portal alumni : das Ehemaligen-Magazin der Universität Potsdam - 9/2012 Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-444943 SN - 1613-2343 IS - 9 ER - TY - CHAP A1 - Lück, Erika A1 - Balderjahn, Ingo A1 - Kamm, Birgit A1 - Greil, Holle A1 - Wallschläger, Hans-Dieter A1 - Jessel, Beate A1 - Böckmann, Christine A1 - Oberhänsli, Roland A1 - Soyez, Konrad A1 - Schmeer, Ernst A1 - Blumenstein, Oswald A1 - Berndt, Klaus-Peter A1 - Edeling, Thomas A1 - Friedrich, Sabine A1 - Kaden, Klaus A1 - Scheller, Frieder W. A1 - Petersen, Hans-Georg A1 - Asche, Hartmut A1 - Bronstert, Axel A1 - Giest, Hartmut A1 - Gaedke, Ursula A1 - Löhmannsröben, Hans-Gerd A1 - Jeltsch, Florian A1 - Jänkel, Ralph A1 - Gzik, Axel A1 - Bork, Hans-Rudolf A1 - Bork, Hans-Rudolf T1 - Umweltforschung für das Land Brandenburg : Arbeitsgruppen und Professuren Y1 - 2000 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-3797 ER - TY - JOUR A1 - Wojcinski, Sebastian A1 - Cassel, Michael A1 - Farrokh, Andre A1 - Soliman, Amr A. A1 - Hille, Ursula A1 - Schmidt, Werner A1 - Degenhardt, Friedrich A1 - Hillemanns, Peter T1 - Variations in the elasticity of breast tissue during the menstrual cycle determined by real-time sonoelastography JF - Journal of ultrasound in medicine N2 - Objectives-The purpose of this study was to determine the dependence of breast tissue elasticity on the menstrual cycle of healthy volunteers by means of real-time sonoelastography. Methods-Twenty-two healthy volunteers (aged 18-33 years) were examined once weekly during two consecutive menstrual cycles using sonoelastography. Group 1 (n = 10) was not taking hormonal medication; group 2 (n = 12) was taking oral contraceptives. Results-The breast parenchyma appeared softer than the dermis and harder than the adipose tissue, and elasticity varied over the menstrual cycle and between groups. Group 1 (no hormone intake) showed continuously increasing elasticity with relatively soft breast parenchyma in the menstrual and follicular phases and harder parenchyma in the luteal phase (P = .012). Group 2 (oral contraceptives) showed no statistically significant changes in breast parenchymal elasticity according to sonoelastography. The parenchyma was generally softer in group 1 compared with group 2 throughout the menstrual cycle (P = .033). The dermis, the subcutaneous adipose tissue, and the pectoralis major muscle showed no changes in elasticity. Comparison of measurements made during the first and the second menstrual cycles showed similar patterns of elasticity in both groups. Conclusions-Sonoelastography is a reproducible method that can be used to determine the dependence of breast parenchyma elasticity on the menstrual cycle and on the intake of hormonal contraceptives. KW - breast tissue KW - elasticity imaging KW - real-time tissue elastography KW - sonoelastography Y1 - 2012 SN - 0278-4297 SN - 1550-9613 VL - 31 IS - 1 SP - 63 EP - 72 PB - American Institute of Ultrasound in Medicine CY - Laurel ER - TY - JOUR A1 - Cohen, Sarel A1 - Hershcovitch, Moshik A1 - Taraz, Martin A1 - Kissig, Otto A1 - Issac, Davis A1 - Wood, Andrew A1 - Waddington, Daniel A1 - Chin, Peter A1 - Friedrich, Tobias T1 - Improved and optimized drug repurposing for the SARS-CoV-2 pandemic JF - PLoS one N2 - The active global SARS-CoV-2 pandemic caused more than 426 million cases and 5.8 million deaths worldwide. The development of completely new drugs for such a novel disease is a challenging, time intensive process. Despite researchers around the world working on this task, no effective treatments have been developed yet. This emphasizes the importance of drug repurposing, where treatments are found among existing drugs that are meant for different diseases. A common approach to this is based on knowledge graphs, that condense relationships between entities like drugs, diseases and genes. Graph neural networks (GNNs) can then be used for the task at hand by predicting links in such knowledge graphs. Expanding on state-of-the-art GNN research, Doshi et al. recently developed the Dr-COVID model. We further extend their work using additional output interpretation strategies. The best aggregation strategy derives a top-100 ranking of 8,070 candidate drugs, 32 of which are currently being tested in COVID-19-related clinical trials. Moreover, we present an alternative application for the model, the generation of additional candidates based on a given pre-selection of drug candidates using collaborative filtering. In addition, we improved the implementation of the Dr-COVID model by significantly shortening the inference and pre-processing time by exploiting data-parallelism. As drug repurposing is a task that requires high computation and memory resources, we further accelerate the post-processing phase using a new emerging hardware-we propose a new approach to leverage the use of high-capacity Non-Volatile Memory for aggregate drug ranking. Y1 - 2023 U6 - https://doi.org/10.1371/journal.pone.0266572 SN - 1932-6203 VL - 18 IS - 3 PB - PLoS CY - San Fransisco ER -