TY - JOUR A1 - Stein, S. A1 - Friedrich, A. M. A1 - Newman, A. T1 - Dependence of possible characteristic earthquakes on spatial sampling: Illustration for the Wasatch seismic zone, Utah Y1 - 2005 SN - 0895-0695 ER - TY - JOUR A1 - Bennett, Richard A. A1 - Friedrich, A. M. A1 - Furlong, K. P. T1 - Codependent histories of the San Andreas and San Jacinto fault zones from inversion of fault displacement rates N2 - The displacement histories of the San Jacinto and southernmost San Andreas fault zones are constrained by offset data with ages in the range of 5 Ma to 5 ka. Apparent discrepancies between long- and short-term average displacement rates can be reconciled with a time-variable rate model. In this model, the displacement rate on the San Andreas decelerated from similar to35 mm/yr at 1.5 Ma to as low as 9 +/- 4 mm/yr by 90 ka. Over this same time period, the rate on the San Jacinto fault zone accelerated from an initial value of zero to a rate of 26 +/- 4 mm/yr. The data also imply that the rate of the San Andreas fault accelerated since ca. 90 ka, from similar to9 mm/yr to the modern rate of 27 +/- 4 mm/yr, whereas the San Jacinto decelerated from 26 +/- 4 mm/yr to the modern rate of 8 +/- 4 mm/yr. The time scale of these changes is significantly longer than the earthquake cycle, but shorter than time scales characteristic of lithospheric-scalle dynamics. The emergence of the San Jacinto fault zone ca. 1.5 Ma coincided with the development of a major restraining bend in the San Andreas fault zone, suggesting that the formation of new subparallell faults could be driven by conditions that inhibit displacement on preexisting faults Y1 - 2004 SN - 0091-7613 ER - TY - JOUR A1 - Kuhnla, A. A1 - Reinthaler, Markus A1 - Braune, Steffen A1 - Maier, A. A1 - Pindur, Gerhard A1 - Lendlein, Andreas A1 - Jung, Friedrich T1 - Spontaneous and induced platelet aggregation in apparently healthy subjects in relation to age JF - Clinical hemorheology and microcirculation : blood flow and vessels N2 - Thrombotic disorders remain the leading cause of mortality and morbidity, despite the fact that anti-platelet therapies and vascular implants are successfully used today. As life expectancy is increasing in western societies, the specific knowledge about processes leading to thrombosis in elderly is essential for an adequate therapeutic management of platelet dysfunction and for tailoring blood contacting implants. This study addresses the limited available data on platelet function in apparently healthy subjects in relation to age, particularly in view of subjects of old age (80-98 years). Apparently healthy subjects between 20 and 98 years were included in this study. Platelet function was assessed by light transmission aggregometry and comprised experiments on spontaneous as well as ristocetin-, ADP- and collagen-induced platelet aggregation. The data of this study revealed a non-linear increase in the maximum spontaneous platelet aggregation (from 3.3% +/- 3.3% to 10.9% +/- 5.9%). The maximum induced aggregation decreased with age for ristocetin (from 85.8% +/- 7.2% to 75.0% +/- 7.8%), ADP (from 88.5% +/- 4.6% to 64.8% +/- 7.3%) and collagen (from 89.5% +/- 3.0% to 64.0% +/- 4.0%) in a non-linear manner (linear regression analysis). These observations indicate that during aging, circulating platelets become increasingly activated but lose their full aggregatory potential, a phenomenon that was earlier termed "platelet exhaustion". In this study we extended the limited existing data for spontaneous and induced platelet aggregation of apparently healthy donors above the age of 75 years. The presented data indicate that the extrapolation of data from a middle age group does not necessarily predict platelet function in apparently healthy subjects of old age. It emphasizes the need for respective studies to improve our understanding of thrombotic processes in elderly humans. Y1 - 2019 U6 - https://doi.org/10.3233/CH-199006 SN - 1386-0291 SN - 1875-8622 VL - 71 IS - 4 SP - 425 EP - 435 PB - IOS Press CY - Amsterdam ER - TY - JOUR A1 - Sangoro, Joshia R. A1 - Iacob, C. A1 - Agapov, A. L. A1 - Wang, Yangyang A1 - Berdzinski, Stefan A1 - Rexhausen, Hans A1 - Strehmel, Veronika A1 - Friedrich, C. A1 - Sokolov, A. P. A1 - Kremer, F. T1 - Decoupling of ionic conductivity from structural dynamics in polymerized ionic liquids JF - Soft matter N2 - Charge transport and structural dynamics in low molecular weight and polymerized 1-vinyl-3-pentylimidazolium bis(trifluoromethylsulfonyl) imide ionic liquids (ILs) are investigated by a combination of broadband dielectric spectroscopy, dynamic mechanical spectroscopy and differential scanning calorimetry. While the dc conductivity and fluidity exhibit practically identical temperature dependence for the non-polymerized IL, a significant decoupling of ionic conduction from structural dynamics is observed for the polymerized IL. In addition, the dc conductivity of the polymerized IL exceeds that of its molecular counterpart by four orders of magnitude at their respective calorimetric glass transition temperatures. This is attributed to the unusually high mobility of the anions especially at lower temperatures when the structural dynamics is significantly slowed down. A simple physical explanation of the possible origin of the remarkable decoupling of ionic conductivity from structural dynamics is proposed. Y1 - 2014 U6 - https://doi.org/10.1039/c3sm53202j SN - 1744-683X SN - 1744-6848 VL - 10 IS - 20 SP - 3536 EP - 3540 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Rienks, Emile D. L. A1 - Wimmer, S. A1 - Sanchez-Barriga, Jaime A1 - Caha, O. A1 - Mandal, Partha Sarathi A1 - Ruzicka, J. A1 - Ney, A. A1 - Steiner, H. A1 - Volobuev, V. V. A1 - Groiss, H. A1 - Albu, M. A1 - Kothleitner, G. A1 - Michalicka, J. A1 - Khan, S. A. A1 - Minar, J. A1 - Ebert, H. A1 - Bauer, G. A1 - Freyse, Friedrich A1 - Varykhalov, Andrei A1 - Rader, Oliver A1 - Springholz, Gunther T1 - Large magnetic gap at the Dirac point in Bi2Te3/MnBi2Te4 heterostructures JF - Nature : the international weekly journal of science N2 - Magnetically doped topological insulators enable the quantum anomalous Hall effect (QAHE), which provides quantized edge states for lossless charge-transport applications(1-8). The edge states are hosted by a magnetic energy gap at the Dirac point(2), but hitherto all attempts to observe this gap directly have been unsuccessful. Observing the gap is considered to be essential to overcoming the limitations of the QAHE, which so far occurs only at temperatures that are one to two orders of magnitude below the ferromagnetic Curie temperature, T-C (ref. (8)). Here we use low-temperature photoelectron spectroscopy to unambiguously reveal the magnetic gap of Mn-doped Bi2Te3, which displays ferromagnetic out-of-plane spin texture and opens up only below T-C. Surprisingly, our analysis reveals large gap sizes at 1 kelvin of up to 90 millielectronvolts, which is five times larger than theoretically predicted(9). Using multiscale analysis we show that this enhancement is due to a remarkable structure modification induced by Mn doping: instead of a disordered impurity system, a self-organized alternating sequence of MnBi2Te4 septuple and Bi2Te3 quintuple layers is formed. This enhances the wavefunction overlap and size of the magnetic gap(10). Mn-doped Bi2Se3 (ref. (11)) and Mn-doped Sb2Te3 form similar heterostructures, but for Bi2Se3 only a nonmagnetic gap is formed and the magnetization is in the surface plane. This is explained by the smaller spin-orbit interaction by comparison with Mn-doped Bi2Te3. Our findings provide insights that will be crucial in pushing lossless transport in topological insulators towards room-temperature applications. Y1 - 2019 U6 - https://doi.org/10.1038/s41586-019-1826-7 SN - 0028-0836 SN - 1476-4687 VL - 576 IS - 7787 SP - 423 EP - 428 PB - Nature Publ. Group CY - London ER - TY - BOOK A1 - Zhang, Shuhao A1 - Plauth, Max A1 - Eberhardt, Felix A1 - Polze, Andreas A1 - Lehmann, Jens A1 - Sejdiu, Gezim A1 - Jabeen, Hajira A1 - Servadei, Lorenzo A1 - Möstl, Christian A1 - Bär, Florian A1 - Netzeband, André A1 - Schmidt, Rainer A1 - Knigge, Marlene A1 - Hecht, Sonja A1 - Prifti, Loina A1 - Krcmar, Helmut A1 - Sapegin, Andrey A1 - Jaeger, David A1 - Cheng, Feng A1 - Meinel, Christoph A1 - Friedrich, Tobias A1 - Rothenberger, Ralf A1 - Sutton, Andrew M. A1 - Sidorova, Julia A. A1 - Lundberg, Lars A1 - Rosander, Oliver A1 - Sköld, Lars A1 - Di Varano, Igor A1 - van der Walt, Estée A1 - Eloff, Jan H. P. A1 - Fabian, Benjamin A1 - Baumann, Annika A1 - Ermakova, Tatiana A1 - Kelkel, Stefan A1 - Choudhary, Yash A1 - Cooray, Thilini A1 - Rodríguez, Jorge A1 - Medina-Pérez, Miguel Angel A1 - Trejo, Luis A. A1 - Barrera-Animas, Ari Yair A1 - Monroy-Borja, Raúl A1 - López-Cuevas, Armando A1 - Ramírez-Márquez, José Emmanuel A1 - Grohmann, Maria A1 - Niederleithinger, Ernst A1 - Podapati, Sasidhar A1 - Schmidt, Christopher A1 - Huegle, Johannes A1 - de Oliveira, Roberto C. L. A1 - Soares, Fábio Mendes A1 - van Hoorn, André A1 - Neumer, Tamas A1 - Willnecker, Felix A1 - Wilhelm, Mathias A1 - Kuster, Bernhard ED - Meinel, Christoph ED - Polze, Andreas ED - Beins, Karsten ED - Strotmann, Rolf ED - Seibold, Ulrich ED - Rödszus, Kurt ED - Müller, Jürgen T1 - HPI Future SOC Lab – Proceedings 2017 T1 - HPI Future SOC Lab – Proceedings 2017 N2 - The “HPI Future SOC Lab” is a cooperation of the Hasso Plattner Institute (HPI) and industry partners. Its mission is to enable and promote exchange and interaction between the research community and the industry partners. The HPI Future SOC Lab provides researchers with free of charge access to a complete infrastructure of state of the art hard and software. This infrastructure includes components, which might be too expensive for an ordinary research environment, such as servers with up to 64 cores and 2 TB main memory. The offerings address researchers particularly from but not limited to the areas of computer science and business information systems. Main areas of research include cloud computing, parallelization, and In-Memory technologies. This technical report presents results of research projects executed in 2017. Selected projects have presented their results on April 25th and November 15th 2017 at the Future SOC Lab Day events. N2 - Das Future SOC Lab am HPI ist eine Kooperation des Hasso-Plattner-Instituts mit verschiedenen Industriepartnern. Seine Aufgabe ist die Ermöglichung und Förderung des Austausches zwischen Forschungsgemeinschaft und Industrie. Am Lab wird interessierten Wissenschaftlern eine Infrastruktur von neuester Hard- und Software kostenfrei für Forschungszwecke zur Verfügung gestellt. Dazu zählen teilweise noch nicht am Markt verfügbare Technologien, die im normalen Hochschulbereich in der Regel nicht zu finanzieren wären, bspw. Server mit bis zu 64 Cores und 2 TB Hauptspeicher. Diese Angebote richten sich insbesondere an Wissenschaftler in den Gebieten Informatik und Wirtschaftsinformatik. Einige der Schwerpunkte sind Cloud Computing, Parallelisierung und In-Memory Technologien. In diesem Technischen Bericht werden die Ergebnisse der Forschungsprojekte des Jahres 2017 vorgestellt. Ausgewählte Projekte stellten ihre Ergebnisse am 25. April und 15. November 2017 im Rahmen der Future SOC Lab Tag Veranstaltungen vor. T3 - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 130 KW - Future SOC Lab KW - research projects KW - multicore architectures KW - In-Memory technology KW - cloud computing KW - machine learning KW - artifical intelligence KW - Future SOC Lab KW - Forschungsprojekte KW - Multicore Architekturen KW - In-Memory Technologie KW - Cloud Computing KW - maschinelles Lernen KW - Künstliche Intelligenz Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-433100 SN - 978-3-86956-475-3 SN - 1613-5652 SN - 2191-1665 IS - 130 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Hempel, Hannes A1 - Savenjie, Tom J. A1 - Stolterfoht, Martin A1 - Neu, Jens A1 - Failla, Michele A1 - Paingad, Vaisakh C. A1 - Kužel, Petr A1 - Heilweil, Edwin J. A1 - Spies, Jacob A. A1 - Schleuning, Markus A1 - Zhao, Jiashang A1 - Friedrich, Dennis A1 - Schwarzburg, Klaus A1 - Siebbeles, Laurens D. A. A1 - Dörflinger, Patrick A1 - Dyakonov, Vladimir A1 - Katoh, Ryuzi A1 - Hong, Min Ji A1 - Labram, John G. A1 - Monti, Maurizio A1 - Butler-Caddle, Edward A1 - Lloyd-Hughes, James A1 - Taheri, Mohammad M. A1 - Baxter, Jason B. A1 - Magnanelli, Timothy J. A1 - Luo, Simon A1 - Cardon, Joseph M. A1 - Ardo, Shane A1 - Unold, Thomas T1 - Predicting solar cell performance from terahertz and microwave spectroscopy JF - Advanced energy materials N2 - Mobilities and lifetimes of photogenerated charge carriers are core properties of photovoltaic materials and can both be characterized by contactless terahertz or microwave measurements. Here, the expertise from fifteen laboratories is combined to quantitatively model the current-voltage characteristics of a solar cell from such measurements. To this end, the impact of measurement conditions, alternate interpretations, and experimental inter-laboratory variations are discussed using a (Cs,FA,MA)Pb(I,Br)(3) halide perovskite thin-film as a case study. At 1 sun equivalent excitation, neither transport nor recombination is significantly affected by exciton formation or trapping. Terahertz, microwave, and photoluminescence transients for the neat material yield consistent effective lifetimes implying a resistance-free JV-curve with a potential power conversion efficiency of 24.6 %. For grainsizes above approximate to 20 nm, intra-grain charge transport is characterized by terahertz sum mobilities of approximate to 32 cm(2) V-1 s(-1). Drift-diffusion simulations indicate that these intra-grain mobilities can slightly reduce the fill factor of perovskite solar cells to 0.82, in accordance with the best-realized devices in the literature. Beyond perovskites, this work can guide a highly predictive characterization of any emerging semiconductor for photovoltaic or photoelectrochemical energy conversion. A best practice for the interpretation of terahertz and microwave measurements on photovoltaic materials is presented. KW - lifetime KW - microwaves KW - mobility KW - solar cells KW - terahertz Y1 - 2022 U6 - https://doi.org/10.1002/aenm.202102776 SN - 1614-6832 SN - 1614-6840 VL - 12 IS - 13 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Friedrich, A. M. A1 - Lee, J. A1 - Wernicke, B. P. A1 - Sieh, K. T1 - Geologic context of geodetic data across a Basin and Range normal fault, Crescent Valley, Nevada N2 - [1] Geodetic strain and late Quaternary faulting in the Basin and Range province is distributed over a region much wider than historic seismicity, which is localized near the margins of the province. In the relatively aseismic interior, both the magnitude and direction of geodetic strain may be inconsistent with the Holocene faulting record. We document the best example of such a disagreement across the NE striking, similar to55degrees NW dipping Crescent normal fault, where a NW oriented, 70 km geodetic baseline records contemporary shortening of similar to2 mm/yr orthogonal to the fault trace. In contrast, our geomorphic, paleoseismic, and geochronologic analyses of the Crescent fault suggest that a large extensional rupture occurred during the late Holocene epoch. An excavation across the fault at Fourmile Canyon reveals that the most recent event occurred at 2.8 +/- 0.1 ka, with net vertical tectonic displacement of 4.6 +/- 0.4 m at this location, corresponding to the release of similar to3 m of accumulated NW-SE extension. Measured alluvial scarp profiles suggest a minimum rupture length of 30 km along the range front for the event, implying a moment magnitude M-w of at least 6.6. No prior event occurred between similar to2.8 ka and similar to6.4 +/- 0.1 ka, the C-14 calender age of strata near the base of the exposed section. Assuming typical slip rates for Basin and Range faults (similar to0.3 mm/yr), these results imply that up to one third, or similar to1 m, of the extensional strain released in the previous earthquake could have reaccumulated across the fault since similar to2.8 ka. However, the contemporary shortening implies that the fault is unloading due to a transient process, whose duration is limited to between 6 years ( geodetic recording time) and 2.8 ka ( the age of the most recent event). These results emphasize the importance of providing accurate geologic data on the timescale of the earthquake cycle in order to evaluate geodetic measurements Y1 - 2004 SN - 0278-7407 ER - TY - JOUR A1 - Wu, Hao A1 - Han, Yijie A1 - Rodriguez Sillke, Yasmina A1 - Deng, Hongzhang A1 - Siddiqui, Sophiya A1 - Treese, Christoph A1 - Schmidt, Franziska A1 - Friedrich, Marie A1 - Keye, Jacqueline A1 - Wan, Jiajia A1 - Qin, Yue A1 - Kühl, Anja A. A1 - Qin, Zhihai A1 - Siegmund, Britta A1 - Glauben, Rainer T1 - Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages JF - EMBO molecular medicine N2 - Tumor-associated macrophages (TAMs) promote tumor growth and metastasis by suppressing tumor immune surveillance. Herein, we provide evidence that the immunosuppressive phenotype of TAMs is controlled by long-chain fatty acid metabolism, specifically unsaturated fatty acids, here exemplified by oleate. Consequently, en-route enriched lipid droplets were identified as essential organelles, which represent effective targets for chemical inhibitors to block in vitro polarization of TAMs and tumor growth in vivo. In line, analysis of human tumors revealed that myeloid cells infiltrating colon cancer but not gastric cancer tissue indeed accumulate lipid droplets. Mechanistically, our data indicate that oleate-induced polarization of myeloid cells depends on the mammalian target of the rapamycin pathway. Thus, our findings reveal an alternative therapeutic strategy by targeting the pro-tumoral myeloid cells on a metabolic level. KW - cancer immunotherapy KW - lipid droplets KW - lipid metabolism KW - tumor microenvironment KW - tumor-associated macrophage Y1 - 2019 U6 - https://doi.org/10.15252/emmm.201910698 SN - 1757-4676 SN - 1757-4684 VL - 11 IS - 11 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Braune, Steffen A1 - Latour, Robert A. A1 - Reinthaler, Markus A1 - Landmesser, Ulf A1 - Lendlein, Andreas A1 - Jung, Friedrich T1 - In Vitro Thrombogenicity Testing of Biomaterials JF - Advanced healthcare materials N2 - The short- and long-term thrombogenicity of implant materials is still unpredictable, which is a significant challenge for the treatment of cardiovascular diseases. A knowledge-based approach for implementing biofunctions in materials requires a detailed understanding of the medical device in the biological system. In particular, the interplay between material and blood components/cells as well as standardized and commonly acknowledged in vitro test methods allowing a reproducible categorization of the material thrombogenicity requires further attention. Here, the status of in vitro thrombogenicity testing methods for biomaterials is reviewed, particularly taking in view the preparation of test materials and references, the selection and characterization of donors and blood samples, the prerequisites for reproducible approaches and applied test systems. Recent joint approaches in finding common standards for a reproducible testing are summarized and perspectives for a more disease oriented in vitro thrombogenicity testing are discussed. KW - biomaterials KW - blood tests KW - implants KW - in vitro KW - thrombogenicity Y1 - 2019 U6 - https://doi.org/10.1002/adhm.201900527 SN - 2192-2640 SN - 2192-2659 VL - 8 IS - 21 PB - Wiley CY - Hoboken ER -