TY  - GEN
A1  - Singh, Alka
A1  - Seitz, Florian
A1  - Eicker, Annette
A1  - Güntner, Andreas
T1  - Water budget analysis within the surrounding of prominent lakes and reservoirs from multi-sensor earth observation data and hydrological models
BT  - case studies of the Aral Sea and Lake Mead
T2  - remote sensing
N2  - The hydrological budget of a region is determined based on the horizontal and vertical water fluxes acting in both inward and outward directions. These integrated water fluxes vary, altering the total water storage and consequently the gravitational force of the region. The time-dependent gravitational field can be observed through the Gravity Recovery and Climate Experiment (GRACE) gravimetric satellite mission, provided that the mass variation is above the sensitivity of GRACE. This study evaluates mass changes in prominent reservoir regions through three independent approaches viz. fluxes, storages, and gravity, by combining remote sensing products, in-situ data and hydrological model outputs using WaterGAP Global Hydrological Model (WGHM) and Global Land Data Assimilation System (GLDAS). The results show that the dynamics revealed by the GRACE signal can be better explored by a hybrid method, which combines remote sensing-based reservoir volume estimates with hydrological model outputs, than by exclusive model-based storage estimates. For the given arid/ semi-arid regions, GLDAS based storage estimations perform better than WGHM.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 453 
KW  - GRACE
KW  - water budget
KW  - reservoir
KW  - water fluxes
KW  - GLDAS
KW  - WGHM
KW  - Aral Sea
KW  - Lake Mead
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-407902
ER  - 
TY  - JOUR
A1  - Singh, Alka
A1  - Seitz, Florian
A1  - Eicker, Annette
A1  - Güntner, Andreas
T1  - Water Budget Analysis within the Surrounding of Prominent Lakes and Reservoirs from Multi-Sensor Earth Observation Data and Hydrological Models: Case Studies of the Aral Sea and Lake Mead
JF  - Remote sensing
N2  - The hydrological budget of a region is determined based on the horizontal and vertical water fluxes acting in both inward and outward directions. These integrated water fluxes vary, altering the total water storage and consequently the gravitational force of the region. The time-dependent gravitational field can be observed through the Gravity Recovery and Climate Experiment (GRACE) gravimetric satellite mission, provided that the mass variation is above the sensitivity of GRACE. This study evaluates mass changes in prominent reservoir regions through three independent approaches viz. fluxes, storages, and gravity, by combining remote sensing products, in-situ data and hydrological model outputs using WaterGAP Global Hydrological Model (WGHM) and Global Land Data Assimilation System (GLDAS). The results show that the dynamics revealed by the GRACE signal can be better explored by a hybrid method, which combines remote sensing-based reservoir volume estimates with hydrological model outputs, than by exclusive model-based storage estimates. For the given arid/ semi-arid regions, GLDAS based storage estimations perform better than WGHM.
KW  - GRACE
KW  - water budget
KW  - reservoir
KW  - water fluxes
KW  - GLDAS
KW  - WGHM
KW  - Aral Sea
KW  - Lake Mead
Y1  - 2016
U6  - https://doi.org/10.3390/rs8110953
SN  - 2072-4292
VL  - 8
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Schlag, Peter M.
A1  - Osterziel, Karl Joseph
A1  - Özcelik, Cemil
A1  - Scherneck, Siegfried
A1  - Wenzel, Katrin
A1  - Daskalow, Katjana
A1  - Herse, Florian
A1  - Seitz, Susanne
A1  - Zacharias, Ute
A1  - Schenk, Jörg A.
A1  - Schulz, Herbert
A1  - Hübner, Norbert
A1  - Micheel, Burkhard
T1  - The protein phosphatase 1 inhibitor KEPI is down regulated in breast cancer cell lines and tissues and involved in the regulation of the tumour suppressor EGR1 via the MEK-ERK pathway
N2  - KEPI is a protein kinase C-potentiated inhibitory protein for type 1 Ser/Thr protein phosphatases. We found no or reduced expression of KEPI in breast cancer cell lines, breast tumors and metastases in comparison to normal breast cell lines and tissues, respectively. KEPI protein expression and ubiquitous localization was detected with a newly generated antibody. Ectopic KEPI expression in MCF7 breast cancer cells induced differential expression of 95 genes, including the up-regulation of the tumor suppressors EGR1 (early growth response 1) and PTEN (phosphatase and tensin homolog), which is regulated by EGR1. We further show that the up-regulation of EGR1 in MCF7/KEPI cells is mediated by MEK-ERK signaling. The inhibition of this pathway by the MEK inhibitor UO126 led to a strong decrease in EGR1 expression in MCF7/KEPI cells. These results reveal a novel role for KEPI in the regulation of the tumor suppressor gene EGR1 via activation of the MEK-ERK MAPK pathway.
Y1  - 2008
UR  - http://www.atypon-link.com/doi/abs/10.1515/BC.2007.062
ER  -