TY - JOUR A1 - Read, Betsy A. A1 - Kegel, Jessica A1 - Klute, Mary J. A1 - Kuo, Alan A1 - Lefebvre, Stephane C. A1 - Maumus, Florian A1 - Mayer, Christoph A1 - Miller, John A1 - Monier, Adam A1 - Salamov, Asaf A1 - Young, Jeremy A1 - Aguilar, Maria A1 - Claverie, Jean-Michel A1 - Frickenhaus, Stephan A1 - Gonzalez, Karina A1 - Herman, Emily K. A1 - Lin, Yao-Cheng A1 - Napier, Johnathan A1 - Ogata, Hiroyuki A1 - Sarno, Analissa F. A1 - Shmutz, Jeremy A1 - Schroeder, Declan A1 - de Vargas, Colomban A1 - Verret, Frederic A1 - von Dassow, Peter A1 - Valentin, Klaus A1 - Van de Peer, Yves A1 - Wheeler, Glen A1 - Dacks, Joel B. A1 - Delwiche, Charles F. A1 - Dyhrman, Sonya T. A1 - Glöckner, Gernot A1 - John, Uwe A1 - Richards, Thomas A1 - Worden, Alexandra Z. A1 - Zhang, Xiaoyu A1 - Grigoriev, Igor V. A1 - Allen, Andrew E. A1 - Bidle, Kay A1 - Borodovsky, M. A1 - Bowler, C. A1 - Brownlee, Colin A1 - Cock, J. Mark A1 - Elias, Marek A1 - Gladyshev, Vadim N. A1 - Groth, Marco A1 - Guda, Chittibabu A1 - Hadaegh, Ahmad A1 - Iglesias-Rodriguez, Maria Debora A1 - Jenkins, J. A1 - Jones, Bethan M. A1 - Lawson, Tracy A1 - Leese, Florian A1 - Lindquist, Erika A1 - Lobanov, Alexei A1 - Lomsadze, Alexandre A1 - Malik, Shehre-Banoo A1 - Marsh, Mary E. A1 - Mackinder, Luke A1 - Mock, Thomas A1 - Müller-Röber, Bernd A1 - Pagarete, Antonio A1 - Parker, Micaela A1 - Probert, Ian A1 - Quesneville, Hadi A1 - Raines, Christine A1 - Rensing, Stefan A. A1 - Riano-Pachon, Diego Mauricio A1 - Richier, Sophie A1 - Rokitta, Sebastian A1 - Shiraiwa, Yoshihiro A1 - Soanes, Darren M. A1 - van der Giezen, Mark A1 - Wahlund, Thomas M. A1 - Williams, Bryony A1 - Wilson, Willie A1 - Wolfe, Gordon A1 - Wurch, Louie L. T1 - Pan genome of the phytoplankton Emiliania underpins its global distribution JF - Nature : the international weekly journal of science N2 - Coccolithophores have influenced the global climate for over 200 million years(1). These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems(2). They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering them visible from space(3). Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean(4). Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate that E. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions. Y1 - 2013 U6 - https://doi.org/10.1038/nature12221 SN - 0028-0836 SN - 1476-4687 VL - 499 IS - 7457 SP - 209 EP - 213 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Tews, Jörg A1 - Esther, Alexandra A1 - Milton, Sue J. A1 - Jeltsch, Florian T1 - Linking a population model with an ecosystem model : assessing the impact of land use and climate change on savanna shrub cover dynamics N2 - In semiarid savannas of Southern Africa current land use practices and climate change may lead to substantial changes of vegetation structure in the near future, however uncertainty remains about the potential consequences and the magnitude of change. In this paper we study the impact of climate change, cattle grazing, and wood cutting on shrub cover dynamics in savannas of the southern Kalahari. We use an established savanna ecosystem model to simulate landscape dynamics in terms of rainfall, fire and distribution of the dominant tree Acacia erioloba. We then incorporate these data into a spatial population model of the common, fleshy-fruited shrub Grewia flava and investigate shrub cover dynamics for a period of 100 years. Depending on the intensity of commercial wood cutting practices tree removal of A. erioloba led to a strong decline of the G. flava population, as shrub recruitment is concentrated in tree sub-canopies due to bird-mediated seed dispersal. Under climate change shrub cover slightly decreased with decreasing precipitation and was unchanged with increase in precipitation variability. Contrarily, grazing by cattle strongly increased shrub cover and facilitated shrub encroachment because of cattle-induced distribution of G. flava seeds into the matrix vegetation. Knowledge of the latter process is particularly important because shrub invasion is a major concern for conservation and savanna rangeland management as a result of its adverse effects on livestock carrying capacity and biodiversity Y1 - 2006 UR - http://www.mendeley.com/research/linking-a-population-model-with-an-ecosystem-model-assessing-the-impact- of-land-use-and-climate-change-on-savanna-shrub-cover-dynamics/#page-1 U6 - https://doi.org/10.1016/j.ecolmodel.2005.11.025 ER - TY - RPRT A1 - Apelojg, Benjamin A1 - Bosse, Stefanie A1 - Geschke, Doreen A1 - Hausner, Christian A1 - Jennek, Julia A1 - Liebner, Saskia A1 - Lipka, Marlies A1 - Marx, Alexandra A1 - Plötner, Kathleen A1 - Reimann, Christina A1 - Sievert, Florian A1 - Spörer, Nadine A1 - Teke, Gülay A1 - Völkner, Katrin A1 - Wabnitz, Juliane A1 - Waschke, Lene A1 - Zielke, Sonja A1 - Zrenner, Laura ED - Spörer, Nadine ED - Völkner, Katrin T1 - Rahmenkonzept der Universitätsschule Potsdam N2 - Das Rahmenkonzept der Universitätsschule Potsdam beschreibt die Wertegrundlage und das pädagogisch-didaktische sowie das wissenschaftliche Fundament einer zu gründenden Universitätsschule Potsdam. Wie andere Universitätsschulen soll sich auch diese Schule durch eine enge und institutionalisierte Beziehung zwischen Schule und Universität auszeichnen, die den ständigen Wissenstransfer zwischen Schulpraxis, Wissenschaft, Lehrkräftebildung und Schulverwaltung unterstützt. Das Rahmenkonzept legt die Grundlagen für eine inklusive Schule, deren Schüler:innen einen Querschnitt der Gesellschaft abbilden, und die in ungleichheitssensiblen Bildungsangeboten alle Bildungsabschlüsse des Landes Brandenburg anbietet. Die Universitätsschule soll den starken Segregationsprozessen in Potsdam entgegenwirken. Im Leitbild werden die Grundwerte (Nachhaltigkeit, Inklusion und Bildungsgerechtigkeit, Menschenrechte und Demokratie, Gemeinschaft, Ganzheitlichkeit) und die Bildungsziele (Transferfähigkeit, kritisch-reflexives Denken und lebensbegleitendes Lernen, Diversitätsbewusstsein und Transkulturalität, Selbstkompetenz und Beziehungskompetenz, Kulturtechniken und digitale Kompetenz) der Universitätsschule dargestellt. Das Pädagogische Konzept veranschaulicht, wie Werte und Bildungsziele in den Bereichen Schulform, Schulkultur, Lernkultur sowie Lernorte und Lernumgebung ausgestaltet werden können. Schließlich wird die Universitätsschule als lernende und lehrende Institution beschrieben, die ein Ort des Transfers von Bildungsinnovationen ist. Dafür soll eine Transferwerkstatt in der Schule verankert werden, die den Wissensaustausch der schulrelevanten Akteur:innen unterstützt und gestaltet. KW - Universitätsschule KW - Bildungsgerechtigkeit KW - Forschung-Praxis-Kooperation KW - Wissenstransfer KW - Lehrkräftebildung Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-491380 ER - TY - THES A1 - Florian, Alexandra T1 - Dynamic analysis of metabolism under circumstances of altererd photorespiratory flux Y1 - 2012 CY - Potsdam ER - TY - JOUR A1 - Frey, Simone K. A1 - Henze, Andrea A1 - Nagl, Britta A1 - Raila, Jens A1 - Scholze, Alexandra A1 - Tepel, Martin A1 - Schweigert, Florian J. A1 - Zidek, Walter T1 - Effect of renal replacement therapy on retinol-binding protein 4 isoforms N2 - Background: Retinol-binding protein 4 (RBP4) levels are elevated in the serum of patients with kidney dysfunction. We recently showed that RBP4 isoforms including apo-RBP4 (RBP4 not bound to retinol) and RBP4 truncated at the C-terminus (RBP4-L, RBP4-LL) are increased in the serum of patients with kidney diseases but not in serum of patients with various liver diseases. The aim of this study was to investigate the effect of renal replacement therapy on RBP4 isoforms. Methods: We investigated serum levels of RBP4, apo-RBP4, holo-RBP4, RBP4-L, RBP4-LL, retinol and transthyretin (TTR) in 18 hemodialysis (HD) patients, 30 patients after renal transplantation (RTx) and in 35 healthy controls. RBP4 and TTR levels were measured by enzyme-linked immunosorbent assay, apo- and holo-RBP4 by native electrophoresis, retinol by high performance liquid chromatography and RBP4-L and RBP4-LL were analyzed by mass spectrometry. Results: HD and RTx patients had elevated RBP4, apo-RBP4 and RBP4-LL levels compared to controls. RTx patients had elevated amounts of RBP4-L compared to controls and elevated RBP4 and apo-RBP4 levels compared to HD patients. Conclusion: The results demonstrate a strong correlation between kidney function and RBP4 isoforms and provide data for investigating the relation of RBP4 and insulin resistance in these patients. Y1 - 2009 UR - http://www.sciencedirect.com/science/journal/00098981 U6 - https://doi.org/10.1016/j.cca.2008.11.008 SN - 0009-8981 ER - TY - JOUR A1 - Esther, Alexandra A1 - Groeneveld, Juergen A1 - Enright, Neal J. A1 - Miller, Ben P. A1 - Lamont, Byron B. A1 - Perry, George L. W. A1 - Blank, F. Benjamin A1 - Jeltsch, Florian T1 - Sensitivity of plant functional types to climate change : classification tree analysis of a simulation model N2 - Question: The majority of studies investigating the impact of climate change on local plant communities ignores changes in regional processes, such as immigration from the regional seed pool. Here we explore: (i) the potential impact of climate change on composition of the regional seed pool, (ii) the influence of changes in climate and in the regional seed pool on local community structure, and (iii) the combinations of life history traits, i.e. plant functional types (PFTs), that are most affected by environmental changes. Location: Fire-prone, Mediterranean-type shrublands in southwestern Australia. Methods: Spatially explicit simulation experiments were conducted at the population level under different rainfall and fire regime scenarios to determine the effect of environmental change on the regional seed pool for 38 PFTs. The effects of environmental and seed immigration changes on local community dynamics were then derived from community-level experiments. Classification tree analyses were used to investigate PFT- specific vulnerabilities to climate change. Results: The classification tree analyses revealed that responses of PFTs to climate change are determined by specific trait characteristics. PFT-specific seed production and community patterns responded in a complex manner to climate change. For example, an increase in annual rainfall caused an increase in numbers of dispersed seeds for some PFTs, but decreased PFT diversity in the community. Conversely, a simulated decrease in rainfall reduced the number of dispersed seeds and diversity of PFTs. Conclusions: PFT interactions and regional processes must be considered when assessing how local community structure will be affected by environmental change. Y1 - 2010 UR - http://www3.interscience.wiley.com/journal/121642345/home U6 - https://doi.org/10.1111/j.1654-1103.2009.01155.x SN - 1100-9233 ER - TY - JOUR A1 - Henze, Andrea A1 - Raila, Jens A1 - Scholze, Alexandra A1 - Zidek, Walter A1 - Tepel, Martin A1 - Schweigert, Florian J. T1 - Does N-Acetylcysteine modulate post-translational modifications of transthyretin in hemodialysis patients? JF - Antioxidants & redox signaling N2 - It is assumed that effects of the thiol antioxidant N-acetylcysteine (NAC) are mediated by interaction with protein-associated cysteine residues, however, information on protein level in vivo are missing. Therefore, we analyzed NAC-induced modifications of the protein transthyretin (TTR) in plasma of hemodialysis patients in a randomized, placebo-controlled study. TTR was selected due to its low molecular weight and the free cysteine residue in the polypeptide chain, which is known to be extensively modified by formation of mixed disulfides. The intravenous application of NAC during a hemodialysis session resulted in a substantial increase of native TTR from median 15% (range 8.8%-30%) to median 40% (37-50) and reduction of S-cysteinylated TTR [51% (44-60) vs. 6.6% (2.4-10)]. Additionally the pronounced formation of a TTR-NAC adduct was detected. However, all these modifications seemed to be reversible. Additionally, in vitro incubation of plasma with NAC confirmed the in vivo results and indicated that changes in post-translational modification pattern of TTR were a function of NAC concentration. Based on these observations and the essential metabolic and biochemical role of protein-associated cysteine residues we hypothesize that the interaction of NAC with proteins may explain altered protein functions due to modification of cysteine residues. Antioxid. Redox Signal. 19, 1166-1172. Y1 - 2013 U6 - https://doi.org/10.1089/ars.2012.5125 SN - 1523-0864 VL - 19 IS - 11 SP - 1166 EP - 1172 PB - Liebert CY - New Rochelle ER - TY - JOUR A1 - Esther, Alexandra A1 - Groeneveld, Jürgen A1 - Enright, Neal J. A1 - Miller, Ben P. A1 - Lamont, Byron B. A1 - Perry, George L. W. A1 - Schurr, Frank Martin A1 - Jeltsch, Florian T1 - Assessing the importance of seed immigration on coexistence of plant functional types in a species-rich ecosystem N2 - Modelling and empirical studies have shown that input from the regional seed pool is essential to maintain local species diversity. However, most of these studies have concentrated on simplified, if not neutral, model systems, and focus on a limited subset of species or on aggregated measures of diversity only (e.g., species richness or Shannon diversity). Thus they ignore more complex species interactions and important differences between species. To gain a better understanding of how seed immigration affects community structure at the local scale in real communities we conducted computer simulation experiments based on plant functional types (PFTs) for a species-rich, fire-prone Mediterranean-type shrubland in Western Australia. We developed a spatially explicit simulation model to explore the community dynamics of 38 PFTs, defined by seven traits - regeneration mode, seed production, seed size, maximum crown diameter, drought tolerance, dispersal mode and seed bank type - representing 78 woody species. Model parameterisation is based on published and unpublished data on the population dynamics of shrub species collected over 18 years. Simulation experiments are based on two contrasting seed immigration scenarios: (1) the 'equal seed input number' scenario, where the number of immigrant seeds is the same for all PFTs, and (2) the 'equal seed input mass' scenario, where the cumulative mass of migrating seeds is the same for all PFTs. Both scenarios were systematically tested and compared for different overall seed input values. Without immigration the local community drifts towards a state with only 13 coexisting PFTs. With increasing immigration rates in terms of overall mass of seeds the simulated number of coexisting PFTs and Shannon diversity quickly approaches values observed in the field. The equal seed mass scenario resulted in a more diverse community than did the seed number scenario. The model successfully approximates the frequency distributions (relative densities) of all individual plant traits except seed size for scenarios associated with equal seed input mass and high immigration rate. However, no scenario satisfactorily approximated the frequency distribution for all traits in combination. Our results show that regional seed input can explain the more aggregated measures of local community structure, and some, but not all, aspects of community composition. This points to the possible importance of other (untested) processes and traits (e.g., dispersal vectors) operating at the local scale. Our modelling framework can readily allow new factors to be systematically investigated, which is a major advantage compared to previous simulation studies, as it allows us to find structurally realistic models, which can address questions pertinent to ecological theory and to conservation management. Y1 - 2008 UR - http://www.sciencedirect.com/science/journal/03043800 U6 - https://doi.org/10.1016/j.ecolmodel.2008.01.014 SN - 0304-3800 ER - TY - JOUR A1 - Henze, Andrea A1 - Frey, Simone K. A1 - Raila, Jens A1 - Scholze, Alexandra A1 - Spranger, Joachim A1 - Weickert, Martin O. A1 - Tepel, Martin A1 - Zidek, Walter A1 - Schweigert, Florian J. T1 - Alterations of retinol-binding protein 4 species in patients with different stages of chronic kidney disease and their relation to lipid parameters N2 - Retinol-binding protein 4 (RBP4) is elevated in patients with chronic kidney disease (CKD) and has been discussed as marker of kidney function. In addition to an elevated concentration, the existence of truncated RBP4 species, RBP4-L (truncated at last C-terminal leucine) and RBP4-LL (truncated at both C-terminal leucines), has been reported in serum of hemodialysis patients. Since little is known about the occurrence of RBP4 species during the progression of CKD it was the aim of this study to analyse this possible association. The presence of RBP4, RBP4-L, RBP4- LL and transthyretin (TTR) was assessed in serum of 45 healthy controls and 52 patients with stage 2-5 of CKD using ELISA and RBP4 immunoprecipitation with subsequent MALDI-TOF-MS analysis. A reduction of glomerular filtration rate was accompanied by a gradual elevation of RBP4 serum levels and relative amounts of RBP4-LL. Correlation analysis revealed a strong association of the RBP4-TTR ratio with parameters of lipid metabolism and with diabetes-related factors. In conclusion, RBP4 serum concentration and the appearance of RBP4-LL seem to be influenced by kidney function. Furthermore, the RBP4-TTR ratio may provide diagnostic potential with regard to metabolic complications in CKD patients. Y1 - 2010 UR - http://www.sciencedirect.com/science/journal/0006291X U6 - https://doi.org/10.1016/j.bbrc.2010.01.082 SN - 0006-291X ER - TY - CHAP A1 - Henze, Andrea A1 - Raila, Jens A1 - Scholze, Alexandra A1 - Schweigert, Florian J. A1 - Tepel, Martin T1 - Administration of N-Acetylcyteine causes beneficial posttranslationalmodifications of transthyretin in hemodialysis patients T2 - Nephrology, dialysis, transplantation Y1 - 2013 SN - 0931-0509 VL - 28 IS - 2 SP - 164 EP - 164 PB - Oxford Univ. Press CY - Oxford ER -