TY  - JOUR
A1  - Wang, Chaoxuan
A1  - Enssle, Jörg
A1  - Pietzner, Anne
A1  - Schmöcker, Christoph
A1  - Weiland, Linda
A1  - Ritter, Oliver
A1  - Jaensch, Monique
A1  - Elbelt, Ulf
A1  - Pagonas, Nikolaos
A1  - Weylandt, Karsten-Henrich
T1  - Essential polyunsaturated fatty acids in blood from patients with and without catheter-proven coronary artery disease
JF  - International journal of molecular sciences
N2  - Coronary artery disease (CAD) is the leading cause of death worldwide. 
Statins reduce morbidity and mortality of CAD. Intake of n-3 polyunsaturated fatty acid (n-3 PUFAs), particularly eicosapentaenoic acid (EPA), is associated with reduced morbidity and mortality in patients with CAD. Previous data indicate that a higher conversion of precursor fatty acids (FAs) to arachidonic acid (AA) is associated with increased CAD prevalence. 
Our study explored the FA composition in blood to assess n-3 PUFA levels from patients with and without CAD. We analyzed blood samples from 273 patients undergoing cardiac catheterization. Patients were stratified according to clinically relevant CAD (n = 192) and those without (n = 81). FA analysis in full blood was performed by gas chromatography. Indicating increased formation of AA from precursors, the ratio of dihomo-gamma-linolenic acid (DGLA) to AA, the delta-5 desaturase index (D5D index) was higher in CAD patients. CAD patients had significantly lower levels of omega-6 polyunsaturated FAs (n-6 PUFA) and n-3 PUFA, particularly EPA, in the blood. 
Thus, our study supports a role of increased EPA levels for cardioprotection.
KW  - coronary artery disease
KW  - triglycerides
KW  - polyunsaturated fatty acids
KW  - n-3 PUFA
KW  - statins
KW  - arachidonic acid
Y1  - 2022
U6  - https://doi.org/10.3390/ijms23020766
SN  - 1422-0067
SN  - 1661-6596
VL  - 23
IS  - 2
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -