TY  - JOUR
A1  - Haegele, Claudia
A1  - Schlagenhauf, Florian
A1  - Rapp, Michael Armin
A1  - Sterzer, Philipp
A1  - Beck, Anne
A1  - Bermpohl, Felix
A1  - Stoy, Meline
A1  - Stroehle, Andreas
A1  - Wittchen, Hans-Ulrich
A1  - Dolan, Raymond J.
A1  - Heinz, Andreas
T1  - Dimensional psychiatry: reward dysfunction and depressive mood across psychiatric disorders
JF  - Psychopharmacology
N2  - A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries.
 We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment.
 During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation.
 Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities.
KW  - Dimensional
KW  - fMRI
KW  - Reward system
KW  - Ventral striatum
KW  - Monetary incentive delay task
KW  - Depressive symptoms
Y1  - 2015
U6  - https://doi.org/10.1007/s00213-014-3662-7
SN  - 0033-3158
SN  - 1432-2072
VL  - 232
IS  - 2
SP  - 331
EP  - 341
PB  - Springer
CY  - New York
ER  - 
TY  - CHAP
A1  - Haegele, Claudia
A1  - Friedel, Eva
A1  - Schlagenhauf, Florian
A1  - Sterzer, Philipp
A1  - Beck, Anne
A1  - Bermpohl, Felix
A1  - Rapp, Michael Armin
A1  - Stoy, Meline
A1  - Stroehle, Andreas
A1  - Dolan, Raymond J.
A1  - Heinz, Andreas
T1  - Reward expectation and affective responses across psychiatric disorders - A dimensional approach
T2  - Biological psychiatry : a journal of psychiatric neuroscience and therapeutics ; a publication of the Society of Biological Psychiatry
KW  - dimensional
KW  - transdiagnostic
KW  - reward system
KW  - ventral striatum
KW  - fMRI
Y1  - 2014
SN  - 0006-3223
SN  - 1873-2402
VL  - 75
IS  - 9
SP  - 91S
EP  - 92S
PB  - Elsevier
CY  - New York
ER  - 
TY  - JOUR
A1  - Sebold, Miriam Hannah
A1  - Deserno, Lorenz
A1  - Nebe, Stefan
A1  - Schad, Daniel
A1  - Garbusow, Maria
A1  - Haegele, Claudia
A1  - Keller, Juergen
A1  - Juenger, Elisabeth
A1  - Kathmann, Norbert
A1  - Smolka, Michael N.
A1  - Rapp, Michael Armin
A1  - Schlagenhauf, Florian
A1  - Heinz, Andreas
A1  - Huys, Quentin J. M.
T1  - Model-based and model-free decisions in alcohol dependence
JF  - Neuropsychobiology : international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography
N2  - Background: Human and animal work suggests a shift from goal-directed to habitual decision-making in addiction. However, the evidence for this in human alcohol dependence is as yet inconclusive. Methods: Twenty-six healthy controls and 26 recently detoxified alcohol-dependent patients underwent behavioral testing with a 2-step task designed to disentangle goal-directed and habitual response patterns. Results: Alcohol-dependent patients showed less evidence of goal-directed choices than healthy controls, particularly after losses. There was no difference in the strength of the habitual component. The group differences did not survive controlling for performance on the Digit Symbol Substitution Task. Conclusion: Chronic alcohol use appears to selectively impair goal-directed function, rather than promoting habitual responding. It appears to do so particularly after nonrewards, and this may be mediated by the effects of alcohol on more general cognitive functions subserved by the prefrontal cortex.
KW  - Alcohol dependence
KW  - Decision-making
KW  - Reinforcement learning
KW  - Dopamine
KW  - Computational psychiatry
Y1  - 2014
U6  - https://doi.org/10.1159/000362840
SN  - 0302-282X
SN  - 1423-0224
VL  - 70
IS  - 2
SP  - 122
EP  - 131
PB  - Karger
CY  - Basel
ER  -