TY - JOUR A1 - Becker, Christine T1 - Information Professional 2011 / Startegien - Allianzen - Netzwerke ; Session 11: Information und Lernen N2 - Tagungsberich Y1 - 2004 ER - TY - JOUR A1 - Becker, Christine T1 - Wissenschaftlicher Dokumentar : neue Tätigkeit für Sehbehinderte Y1 - 1994 ER - TY - JOUR A1 - Laucht, Manfred A1 - Treutlein, Jens A1 - Schmid, Brigitte A1 - Blomeyer, Dorothea A1 - Becker, Katja A1 - Buchmann, Arlette F. A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Jennen-Steinmetz, Christine A1 - Rietschel, Marcella A1 - Zimmermann, Ulrich S. A1 - Banaschewski, Tobias T1 - Impact of psychosocial adversity on alcohol intake in young adults : moderation by the LL genotype of the serotonin transporter polymorphism N2 - Background: Evidence from animal studies supports a role for serotonin transporter gene promoter polymorphism (5-HTTLPR) gene-environment interaction (G X E) in the development of excessive alcohol intake. Few studies in humans have been conducted on this topic, yielding inconsistent results. The present study aims to further explore G x E between 5-HTTLPR and exposure to psychosocial adversity on alcohol consumption in a high-risk community sample of young adults. Methods: Data were collected as part of the Mannheim Study of Children at Risk, an ongoing epidemiological cohort study following the outcome of early risk factors from birth into young adulthood. At age 19 years, 309 participants (142 male participants, 167 female participants) were genotyped for the biallelic and triallelic 5-HTTLPR and were administered a 45-day alcohol timeline follow-back interview, providing measures of the total number of drinks and the number of binge drinking days. Psychosocial adversity was assessed at birth (family adversity) and at age 19 (negative life events). Results: In contrast to various previous reports, a significant G x E emerged, indicating that, when exposed to high psychosocial adversity, individuals with the LL genotype of 5-HTTLPR exhibited more hazardous drinking than those carrying the S allele or those without exposure to adversity. This effect, which was confined to male participants, held both for different classifications of 5-HTTLPR and different types of adversity. Conclusions: One explanation for the discrepant results might be heterogeneity in alcohol phenotypes. While the L allele relates more strongly to early-onset alcoholism, the S allele may be linked more closely to alcohol use associated with anxiety and depression. Y1 - 2009 UR - http://www.sciencedirect.com/science/journal/00063223 U6 - https://doi.org/10.1016/j.biopsych.2009.02.010 SN - 0006-3223 ER - TY - JOUR A1 - Becker, Christine T1 - Effekte und Barrieren der Wissensvermittlung zur Nutzung von externen Datenbanken Y1 - 1993 SN - 3-631-46947-0 ER - TY - JOUR A1 - Becker, Christine T1 - Zugang zum Wissen der Welt : Informationsermittlung aus internationalen Online-Datenbanken Y1 - 1996 ER - TY - JOUR A1 - Becker, Christine T1 - Lost in Hyperspace? - oder: Erfolgreiches Suchen im World Wide Web Y1 - 1996 ER - TY - BOOK A1 - Becker, Christine T1 - Zugang zum Wissen der Welt : Informationsermittlung aus internationalen Online-Datenbanken ; Einführung in die Möglichkeiten der Nutzung von Online-Datenbanken für die Literaturrecherche T3 - Wissensvermittlung und Informationstechnologien in den Geistes- und Sozialwissenschaften Y1 - 1995 VL - 3 PB - ZEIK CY - Potsdam ER - TY - BOOK A1 - Becker, Christine T1 - Integration einer fächerübergreifenden aber fachbezogenen informationstechnologischen Grundbildung in die studentische Ausbildung an der Universität Potsdam : Vortrag auf dem Deutschen Dokumentartag 26. bis 28. 9. 1995 in Potsdam Y1 - 1995 UR - http://www.uni-potsdam.de/u/zeik/vortrag.htm ER - TY - JOUR A1 - Becker, Christine T1 - Publizieren und Präsentieren eigener Informationsangebote im World Wide Web Y1 - 1997 SN - 3-9804450-3-8 ER - TY - JOUR A1 - Nikitopoulos, Joerg A1 - Zohsel, Katrin A1 - Blomeyer, Dorothea A1 - Buchmann, Arlette F. A1 - Schmid, Brigitte A1 - Jennen-Steinmetz, Christine A1 - Becker, Katja A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Brandeis, Daniel A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Are infants differentially sensitive to parenting? Early maternal care, DRD4 genotype and externalizing behavior during adolescence JF - Journal of psychiatric research KW - DRD4 KW - Early maternal care KW - Externalizing behavior KW - Adolescence KW - Gene-environment interaction Y1 - 2014 U6 - https://doi.org/10.1016/j.jpsychires.2014.08.012 SN - 0022-3956 SN - 1879-1379 VL - 59 SP - 53 EP - 59 PB - Elsevier CY - Oxford ER -