TY - GEN A1 - Ventura-Bort, Carlos A1 - Wirkner, Janine A1 - Genheimer, Hannah A1 - Wendt, Julia A1 - Hamm, Alfons O. A1 - Weymar, Mathias T1 - Effects of Transcutaneous Vagus Nerve Stimulation (tVNS) on the P300 and Alpha-Amylase Level BT - A Pilot Study T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Recent research suggests that the P3b may be closely related to the activation of the locus coeruleus-norepinephrine (LC-NE) system. To further study the potential association, we applied a novel technique, the non-invasive transcutaneous vagus nerve stimulation (tVNS), which is speculated to increase noradrenaline levels. Using a within-subject cross-over design, 20 healthy participants received continuous tVNS and sham stimulation on two consecutive days (stimulation counterbalanced across participants) while performing a visual oddball task. During stimulation, oval non-targets (standard), normal-head (easy) and rotated-head (difficult) targets, as well as novel stimuli (scenes) were presented. As an indirect marker of noradrenergic activation we also collected salivary alpha-amylase (sAA) before and after stimulation. Results showed larger P3b amplitudes for target, relative to standard stimuli, irrespective of stimulation condition. Exploratory post hoc analyses, however, revealed that, in comparison to standard stimuli, easy (but not difficult) targets produced larger P3b (but not P3a) amplitudes during active tVNS, compared to sham stimulation. For sAA levels, although main analyses did not show differential effects of stimulation, direct testing revealed that tVNS (but not sham stimulation) increased sAA levels after stimulation. Additionally, larger differences between tVNS and sham stimulation in P3b magnitudes for easy targets were associated with larger increase in sAA levels after tVNS, but not after sham stimulation. Despite preliminary evidence for a modulatory influence of tVNS on the P3b, which may be partly mediated by activation of the noradrenergic system, additional research in this field is clearly warranted. Future studies need to clarify whether tVNS also facilitates other processes, such as learning and memory, and whether tVNS can be used as therapeutic tool. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 473 KW - EEG KW - P300 KW - tVNS KW - norepinephrine KW - locus coeruleus KW - salivary alpha-amylase Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-419259 IS - 473 ER - TY - GEN A1 - Ribes, Pablo A1 - Ventura-Bort, Carlos A1 - Poy, Rosario A1 - Segarra, Pilar A1 - Rodriguez, Sara A1 - Branchadell, Victoria A1 - Molto, Javier T1 - N2 and P3 modulation in a modified go/nogo task BT - the role of disinhibition (Poster) T2 - Psychophysiology : journal of the Society for Psychophysiological Research N2 - This study examined the relationships between the three phenotypic domains of the triarchic model of psychopathy —boldness, meanness, disinhibition— and electrophysiological indices of inhibitory control (NoGo-N2/NoGo-P3). EEG data from a 256-channel dense array were recorded while participants (135 un-dergraduates assessed via the Triarchic Psychopathy Measure) performed a Go/NoGo task with three types of stimuli (60% frequent-Go, 20% infrequent-Go, 20% infrequent-NoGo). N2 was defined as the mean amplitude between 240 ms and 340 ms after stimuli onset over fronto-central sensors on correct trials; P300 was defined as the mean amplitude between 350 ms and 550 ms after stimuli onset over centro-parietal sensors on correct trials. Multiple regression analyses using gender-corrected triarchic scores as predictors revealed that only Disinhibition scores significantly predicted reduced NoGo-N2 amplitudes (3.5% explained variance, beta weight = .23, p < .05) and reduced P3 amplitudes for NoGo and infrequent-Go trials (3.1 and 3.2% explained variance, respectively, beta weights = -.21, ps < .05). Our results indicate that high disinhibition entails deviations in early conflict monitoring processes (reduced NoGo-N2), as well as in latter evaluative and updating processing stages of infrequent events (reduced NoGo-P3 and infrequent-Go-P3). The null contribution of meanness and boldness domains in these results suggests that N2 and P3 amplitudes in Go/NoGo tasks could be considered as neurobiological indices of the externalizing tendencies comprised in this personality disorder. KW - N2/P3 KW - Inhibitory Control KW - Triarchic Model of Psychopathy Y1 - 2018 SN - 0048-5772 SN - 1469-8986 VL - 55 SP - S91 EP - S91 PB - Wiley CY - Hoboken ER - TY - THES A1 - Ventura-Bort, Carlos T1 - Temporo-spatial dynamics of the impact of emotional contexts on visual processing and memory T1 - Zeitlich-räumliche Dynamik der Auswirkungen emotionaler Kontexte auf die visuelle Verarbeitung und das Gedächtnis N2 - It has frequently been observed that single emotional events are not only more efficiently processed, but also better remembered, and form longer-lasting memory traces than neutral material. However, when emotional information is perceived as a part of a complex event, such as in the context of or in relation to other events and/or source details, the modulatory effects of emotion are less clear. The present work aims to investigate how emotional, contextual source information modulates the initial encoding and subsequent long-term retrieval of associated neutral material (item memory) and contextual source details (contextual source memory). To do so, a two-task experiment was used, consisting of an incidental encoding task in which neutral objects were displayed over different contextual background scenes which varied in emotional content (unpleasant, pleasant, and neutral), and a delayed retrieval task (1 week), in which previously-encoded objects and new ones were presented. In a series of studies, behavioral indices (Studies 2, 3, and 5), event-related potentials (ERPs; Studies 1-4), and functional magnetic resonance imaging (Study 5) were used to investigate whether emotional contexts can rapidly tune the visual processing of associated neutral information (Study 1) and modulate long-term item memory (Study 2), how different recognition memory processes (familiarity vs. recollection) contribute to these emotion effects on item and contextual source memory (Study 3), whether the emotional effects of item memory can also be observed during spontaneous retrieval (Sstudy 4), and which brain regions underpin the modulatory effects of emotional contexts on item and contextual source memory (Study 5). In Study 1, it was observed that emotional contexts by means of emotional associative learning, can rapidly alter the processing of associated neutral information. Neutral items associated with emotional contexts (i.e. emotional associates) compared to neutral ones, showed enhanced perceptual and more elaborate processing after one single pairing, as indexed by larger amplitudes in the P100 and LPP components, respectively. Study 2 showed that emotional contexts produce longer-lasting memory effects, as evidenced by better item memory performance and larger ERP Old/New differences for emotional associates. In Study 3, a mnemonic differentiation was observed between item and contextual source memory which was modulated by emotion. Item memory was driven by familiarity, independently of emotional contexts during encoding, whereas contextual source memory was driven by recollection, and better for emotional material. As in Study 2, enhancing effects of emotional contexts for item memory were observed in ERPs associated with recollection processes. Likewise, for contextual source memory, a pronounced recollection-related ERP enhancement was observed for exclusively emotional contexts. Study 4 showed that the long-term recollection enhancement of emotional contexts on item memory can be observed even when retrieval is not explicitly attempted, as measured with ERPs, suggesting that the emotion enhancing effects on memory are not related to the task embedded during recognition, but to the motivational relevance of the triggering event. In Study 5, it was observed that enhancing effects of emotional contexts on item and contextual source memory involve stronger engagement of the brain's regions which are associated with memory recollection, including areas of the medial temporal lobe, posterior parietal cortex, and prefrontal cortex. Taken together, these findings suggest that emotional contexts rapidly modulate the initial processing of associated neutral information and the subsequent, long-term item and contextual source memories. The enhanced memory effects of emotional contexts are strongly supported by recollection rather than familiarity processes, and are shown to be triggered when retrieval is both explicitly and spontaneously attempted. These results provide new insights into the modulatory role of emotional information on the visual processing and the long-term recognition memory of complex events. The present findings are integrated into the current theoretical models and future ventures are discussed. N2 - Es wurde häufig beobachtet, dass einzelne emotionale Ereignisse effizienter verarbeitet und besser erinnert werden und länger anhaltende Gedächtnisspuren bilden als neutrales Material. Wenn jedoch emotionale Informationen als Teil eines komplexen Ereignisses wahrgenommen werden, wie beispielsweise im Kontext oder in Bezug auf andere Ereignisse und/oder Quellendetails, sind die modulierenden Einflüsse von Emotionen weniger klar. Die vorliegende Arbeit zielt darauf ab zu untersuchen, wie emotionale, kontextuelle Quelleninformationen die anfängliche Kodierung und den anschließenden langfristigen Abruf von zugehörigem neutralen Material (Itemgedächtnis) und kontextuellen Quellendetails (Quellengedächtnis) modulieren. Dazu wurde ein Zwei-Aufgaben-Experiment verwendet, bestehend aus einer nicht instruierten Enkodierungsaufgabe, bei der neutrale Objekte eingebettet in verschiedene kontextuelle Hintergrundszenen dargeboten wurden, die in ihrem emotionalen Inhalt variierten (unangenehm, angenehm und neutral), und einer verzögerten Abrufaufgabe (1 Woche), bei der zuvor enkodierte und neue Objekte präsentiert wurden. In einer Reihe von Studien wurden Verhaltensindizes (Studien 2-5), ereigniskorrelierte Potenziale (EKPs; Studien 1-4) und funktionelle Magnetresonanztomographie (Studie 5) verwendet, um zu untersuchen, ob emotionale Kontexte die visuelle Verarbeitung der zugehörigen neutralen Informationen kurzfristig verändern können (Studie 1) und das Langzeitgedächtnis modulieren (Studie 2), wie verschiedene Prozesse des Wiedererkennens (Vertrautheit vs. Rekollektion) zu diesen Emotionseffekten auf das Item- und das kontextuelle Quellengedächtnis beitragen (Studie 3), ob die emotionalen Effekte auf das Itemgedächtnis auch bei der spontanen Abfrage beobachtet werden können (Studie 4) und über welche Hirnregionen die modulierenden Effekte emotionaler Kontexte auf das Item- und kontextuelle Quellengedächtnis vermittelt werden (Studie 5). In Studie 1 wurde beobachtet, dass emotionale Kontexte durch emotionales assoziatives Lernen die Verarbeitung der zugehörigen neutralen Informationen kurzfristig verändern können. Neutrale Elemente, die mit emotionalen Kontexten verbunden sind (im Folgenden „emotional Assoziierte“ genannt), zeigten nach einer einzigen Paarung im Vergleich zu neutralen Elementen eine verbesserte perzeptuelle und elaboriertere Verarbeitung, wie durch höhere Amplituden in den P100- bzw. LPP-Komponenten nachgewiesen wurde. Studie 2 zeigte, dass emotionale Kontexte länger anhaltende Gedächtniseffekte erzeugen, was sich in einer besseren Itemgedächtnisleistung und größeren EKP-alt/neu Unterschieden für emotional Assoziierte zeigte. In Studie 3 wurde eine mnemonische Differenzierung zwischen Item- und kontextuellem Quellengedächtnis beobachtet, die durch Emotionen moduliert wurde. Das Itemgedächtnis wurde durch den Prozess der Vertrautheit getrieben unabhängig von den emotionalen Kontexten während der Enkodierung. Das kontextuelle Quellengedächtnis wurde dagegen durch Rekollektion getrieben und war besser für emotionales Material. Wie in Studie 2 wurden in EKPs, die mit Rekollektionsprozessen in Verbindung stehen, verstärkende Effekte von emotionalen Kontexten für das Itemgedächtnis beobachtet. Ebenso wurde für das kontextuelle Quellengedächtnis eine ausgeprägte Rekollektionsbezogene Potenzierung der EKPs ausschließlich für emotionale Kontexte beobachtet. Studie 4 zeigte, dass die langfristige Verstärkung der Rekollektion, die emotionale Kontexten im Itemgedächtnis verursachen, auch dann beobachtet werden kann, wenn der Abruf nicht explizit instruiert wird. Dieser Befund zum spontanen Erinnern deutet darauf hin, dass die gedächtnissteigernden Effekte von Emotionen nicht mit der Aufgabe zusammenhängen, die während des Abrufs gestellt wurde, sondern mit der motivationalen Relevanz des auslösenden Ereignisses. In Studie 5 wurde beobachtet, dass an der verstärkenden Wirkung von emotionalen Kontexten auf das Item- und kontextuelle Quellengedächtnis solche Hirnregionen beteiligt sind, die mit der Rekollektionsprozessen assoziiert werden, einschließlich der Bereiche des medialen Temporallappens, des posterioren parietalen Kortex und des präfrontalen Kortex. Zusammengenommen deuten diese Ergebnisse darauf hin, dass emotionale Kontexte die anfängliche Verarbeitung der zugehörigen neutralen Informationen und der nachfolgenden, langfristigen Erinnerungen an Items und kontextuelle Quellen schnell modulieren. Die durch emotionaler Kontexte ausgelösten Gedächtniseffekte werden eher durch Rekollektions- und weniger durch Vertrautheitsprozesse vermittelt und zeigen sich sowohl bei expliziten als auch bei spontanen Abruf. Diese Ergebnisse liefern neue Erkenntnisse über die modulierende Rolle emotionaler Informationen bei der visuellen Verarbeitung und der Langzeiterinnerung an komplexe Ereignisse. Die vorliegenden Erkenntnisse werden in aktuelle theoretische Modelle integriert und zukünftige Forschungsperspektiven werden diskutiert. KW - memory KW - fMRI KW - Emotion KW - emotion KW - EEG KW - Gedächtnis KW - EEG KW - fMRT Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-550236 ER - TY - GEN A1 - Weymar, Mathias A1 - Ventura-Bort, Carlos A1 - Wendt, Julia A1 - Lischke, Alexander T1 - Behavioral and neural evidence of enhanced long-term memory for untrustworthy faces T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - In daily life, we automatically form impressions of other individuals on basis of subtle facial features that convey trustworthiness. Because these face-based judgements influence current and future social interactions, we investigated how perceived trustworthiness of faces affects long-term memory using event-related potentials (ERPs). In the current study, participants incidentally viewed 60 neutral faces differing in trustworthiness, and one week later, performed a surprise recognition memory task, in which the same old faces were presented intermixed with novel ones. We found that after one week untrustworthy faces were better recognized than trustworthy faces and that untrustworthy faces prompted early (350–550 ms) enhanced frontal ERP old/new differences (larger positivity for correctly remembered old faces, compared to novel ones) during recognition. Our findings point toward an enhanced long-lasting, likely familiarity-based, memory for untrustworthy faces. Even when trust judgments about a person do not necessarily need to be accurate, a fast access to memories predicting potential harm may be important to guide social behaviour in daily life. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 594 KW - Recognition Memory KW - Facial Expressions KW - Trustworthiness KW - Recollection KW - Amygdala KW - Metaanalysis KW - Information KW - Appearance KW - Perception KW - Trust Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-442925 SN - 1866-8364 IS - 594 ER - TY - JOUR A1 - Ventura-Bort, Carlos A1 - Schnabel, Ella A1 - Wendt, Julia A1 - Weymar, Mathias T1 - Influence of resting heart rate variability on affect processing in different induction contexts JF - Psychophysiology : journal of the Society for Psychophysiological Research KW - HRV KW - Emotion KW - Startle Y1 - 2020 SN - 0048-5772 SN - 1469-8986 SN - 1540-5958 VL - 57 SP - S39 EP - S39 PB - Wiley-Blackwell CY - Malden ER - TY - JOUR A1 - Ventura-Bort, Carlos A1 - Wirkner, Janine A1 - Genheimer, Hannah A1 - Wendt, Julia A1 - Hamm, Alfons O. A1 - Weymar, Mathias T1 - Effects of Transcutaneous Vagus Nerve Stimulation (tVNS) on the P300 and Alpha-Amylase Level BT - A Pilot Study JF - Frontiers in Human Neuroscience N2 - Recent research suggests that the P3b may be closely related to the activation of the locus coeruleus-norepinephrine (LC-NE) system. To further study the potential association, we applied a novel technique, the non-invasive transcutaneous vagus nerve stimulation (tVNS), which is speculated to increase noradrenaline levels. Using a within-subject cross-over design, 20 healthy participants received continuous tVNS and sham stimulation on two consecutive days (stimulation counterbalanced across participants) while performing a visual oddball task. During stimulation, oval non-targets (standard), normal-head (easy) and rotated-head (difficult) targets, as well as novel stimuli (scenes) were presented. As an indirect marker of noradrenergic activation we also collected salivary alpha-amylase (sAA) before and after stimulation. Results showed larger P3b amplitudes for target, relative to standard stimuli, irrespective of stimulation condition. Exploratory post hoc analyses, however, revealed that, in comparison to standard stimuli, easy (but not difficult) targets produced larger P3b (but not P3a) amplitudes during active tVNS, compared to sham stimulation. For sAA levels, although main analyses did not show differential effects of stimulation, direct testing revealed that tVNS (but not sham stimulation) increased sAA levels after stimulation. Additionally, larger differences between tVNS and sham stimulation in P3b magnitudes for easy targets were associated with larger increase in sAA levels after tVNS, but not after sham stimulation. Despite preliminary evidence for a modulatory influence of tVNS on the P3b, which may be partly mediated by activation of the noradrenergic system, additional research in this field is clearly warranted. Future studies need to clarify whether tVNS also facilitates other processes, such as learning and memory, and whether tVNS can be used as therapeutic tool. KW - EEG KW - P300 KW - tVNS KW - norepinephrine KW - locus coeruleus KW - salivary alpha-amylase Y1 - 2018 U6 - https://doi.org/10.3389/fnhum.2018.00202 SN - 1662-5161 VL - 12 SP - 1 EP - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Weymar, Mathias A1 - Ventura-Bort, Carlos A1 - Wendt, Julia A1 - Lischke, Alexander T1 - Behavioral and neural evidence of enhanced long-term memory for untrustworthy faces JF - Scientific Reports N2 - In daily life, we automatically form impressions of other individuals on basis of subtle facial features that convey trustworthiness. Because these face-based judgements influence current and future social interactions, we investigated how perceived trustworthiness of faces affects long-term memory using event-related potentials (ERPs). In the current study, participants incidentally viewed 60 neutral faces differing in trustworthiness, and one week later, performed a surprise recognition memory task, in which the same old faces were presented intermixed with novel ones. We found that after one week untrustworthy faces were better recognized than trustworthy faces and that untrustworthy faces prompted early (350–550 ms) enhanced frontal ERP old/new differences (larger positivity for correctly remembered old faces, compared to novel ones) during recognition. Our findings point toward an enhanced long-lasting, likely familiarity-based, memory for untrustworthy faces. Even when trust judgments about a person do not necessarily need to be accurate, a fast access to memories predicting potential harm may be important to guide social behaviour in daily life. KW - Recognition Memory KW - Facial Expressions KW - Trustworthiness KW - Recollection KW - Amygdala KW - Metaanalysis KW - Information KW - Appearance KW - Perception KW - Trust Y1 - 2019 U6 - https://doi.org/10.1038/s41598-019-55705-7 SN - 2045-2322 VL - 9 PB - Macmillan Publishers Limited CY - London ER - TY - JOUR A1 - Ventura-Bort, Carlos A1 - Wirkner, Janine A1 - Dolcos, Florin A1 - Wendt, Julia A1 - Hamm, Alfons O. A1 - Weymar, Mathias T1 - Enhanced spontaneous retrieval of cues from emotional events: an ERP study JF - Biological psychology N2 - Recent evidence points to enhanced episodic memory retrieval not only for emotional items but also for neutral information encoded in emotional contexts. However, prior research only tested instructed explicit recognition, and hence here we investigated whether memory retrieval is also heightened for cues from emotional contexts when retrieval is not explicitly probed. During the first session of a two-session experiment, neutral objects were presented on different background scenes varying in emotional and neutral contents. One week later, objects were presented again (with no background) intermixed with novel objects. In both sessions, participants were instructed to attentively watch the stimuli (free viewing procedure), and during the second session, ERPs were also collected to measure the ERP Old/New effect, an electrophysiological correlate of episodic memory retrieval. Analyses were performed using cluster-based permutation tests in order to identify reliable spatiotemporal ERP differences. Based on this approach, old relative to new objects, were associated with larger ERP positivity in an early (364-744 ms) and late time window (760-1148 ms) over distinct central electrode clusters. Interestingly, significant late ERP Old/New differences were only observed for objects previously encoded with emotional, but not neutral scenes (504 to 1144 ms). Because these ERP differences were observed in a non-instructed retrieval context, our results indicate that long-term, spontaneous retrieval for neutral objects, is particularly heightened if encoded within emotionally salient contextual information. These findings may assist in understanding mechanisms underlying spontaneous retrieval of emotional associates and the utility of ERPs to study maladaptive involuntary memories in trauma- and stress-related disorders. KW - Event-related potentials KW - ERP KW - Emotion KW - Retrieval KW - Spontaneous memory KW - Old/New effect Y1 - 2019 U6 - https://doi.org/10.1016/j.biopsycho.2019.107742 SN - 0301-0511 SN - 1873-6246 VL - 148 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Ventura-Bort, Carlos A1 - Wirkner, Janine A1 - Wendt, Julia A1 - Hamm, Alfons O. A1 - Weymar, Mathias T1 - Establishment of emotional memories is mediated by vagal nerve activation BT - evidence from noninvasive taVNS JF - The journal of neuroscience : the official journal of the Society for Neuroscience N2 - Emotional memories are better remembered than neutral ones, but the mechanisms leading to this memory bias are not well under-stood in humans yet. Based on animal research, it is suggested that the memory-enhancing effect of emotion is based on central nor-adrenergic release, which is triggered by afferent vagal nerve activation. To test the causal link between vagus nerve activation and emotional memory in humans, we applied continuous noninvasive transcutaneous auricular vagus nerve stimulation (taVNS) during exposure to emotional arousing and neutral scenes and tested subsequent, long-term recognition memory after 1 week. We found that taVNS, compared with sham, increased recollection-based memory performance for emotional, but not neutral, material. These findings were complemented by larger recollection-related brain potentials (parietal ERP Old/New effect) during retrieval of emotional scenes encoded under taVNS, compared with sham. Furthermore, brain potentials recorded during encoding also revealed that taVNS facilitated early attentional discrimination between emotional and neutral scenes. Extending animal research, our behavioral and neu-ral findings confirm a modulatory influence of the vagus nerve in emotional memory formation in humans. KW - emotion KW - ERPs KW - memory KW - Old KW - New effect KW - LPP KW - vagus nerve KW - tVNS Y1 - 2021 U6 - https://doi.org/10.1523/JNEUROSCI.2329-20.2021 SN - 1529-2401 VL - 41 IS - 36 SP - 7636 EP - 7648 PB - Society for Neuroscience CY - Washington, DC ER - TY - GEN A1 - Weymar, Mathias A1 - Ventura-Bort, Carlos A1 - Wirkner, Janine A1 - Genheimer, Hannah A1 - Wendt, Julia A1 - Hamm, Alfons O. T1 - Effects of Transcutaneous Vagus Vagus Nerve Stimulation (TVNS) on selective attentions and emotional episodic memory : findings from ERP research T2 - Psychophysiology : journal of the Society for Psychophysiological Research N2 - Recent research indicates that non- invasive stimulation of the afferent auricular vagal nerve (tVNS) may modulate various cognitive and affec-tive functions, likely via activation of the locus coeruleus- norepinephrine (LC- NE) system. In a series of ERP studies we found that the attention- related P300 component is enhanced during continuous vagal stimula-tion, compared to sham, which is also related to increased salivary alpha amylase levels (a putative indirect marker for central NE activation). In another study, we investigated the effect of continuous tVNS on the late positive potential (LPP), an electrophysiological index for motivated atten-tion toward emotionally evocative cues, and the effects of tVNS on later recognition memory (1- week delay). Here, vagal stimulation prompted earlier LPP differences (300- 500 ms) between unpleasant and neutral scenes. During retrieval, vagal stimulation significantly improved memory performance for unpleasant, but not neutral pictures, compared to sham stimulation, which was also related to enhanced salivary alpha amylase levels. In line, unpleasant images encoded under tVNS compared to sham stimulation also produced enhanced ERP old/new differences (500- 800 ms) during retrieval indicating better recollection. Taken together, our studies suggest that tVNS facilitates attention, learning and episodic memory, likely via afferent projections to the arousal- modulated LC- NE system. We will, however, also show data that point to critical stimulation parameters (likely duration and frequency) that need to be considered when applying tVNS Y1 - 2019 U6 - https://doi.org/10.1111/psyp.13501 SN - 0048-5772 SN - 1469-8986 VL - 56 SP - S12 EP - S12 PB - Wiley CY - Hoboken ER -