TY - JOUR A1 - Thierbach, René A1 - Drewes, Gunnar A1 - Fusser, Markus A1 - Voigt, Anja A1 - Kuhlow, Doreen A1 - Blume, Urte A1 - Schulz, Tim Julius A1 - Reiche, Carina A1 - Glatt, Hansruedi A1 - Epe, Bernd A1 - Steinberg, Pablo A1 - Ristow, Michael T1 - The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals N2 - DNA-repair mechanisms enable cells to maintain their genetic information by protecting it from mutations that may cause malignant growth. Recent evidence suggests that specific DNA-repair enzymes contain ISCs (iron-sulfur clusters). The nuclear-encoded protein frataxin is essential for the mitochondrial biosynthesis of ISCs. Frataxin deficiency causes a neurodegenerative disorder named Friedreich's ataxia in humans. Various types of cancer occurring at young age are associated with this disease, and hence with frataxin deficiency. Mice carrying a hepatocyte- specific disruption of the frataxin gene develop multiple liver tumours for unresolved reasons. In the present study, we show that frataxin deficiency in murine liver is associated with increased basal levels of oxidative DNA base damage. Accordingly, eukaryotic V79 fibroblasts overexpressing human frataxin show decreased basal levels of these modifications, while prokaryotic Salmonella enterica serotype Typhimurium TA 104 strains transformed with human frataxin show decreased mutation rates. The repair rates of oxidative DNA base modifications in V79 cells overexpressing frataxin were significantly higher than in control cells. Lastly, cleavage activity related to the ISC-independent repair enzyme 8-oxoguanine glycosylase was found to be unaltered by frataxin overexpression. These findings indicate that frataxin modulates DNA-repair mechanisms probably due to its impact on ISC-dependent repair proteins, linking mitochondrial dysfunction to DNA repair and tumour initiation. Y1 - 2010 UR - http://www.biochemj.org/bj/toc.htm U6 - https://doi.org/10.1042/Bj20101116 SN - 0264-6021 ER - TY - BOOK A1 - Schubarth, Wilfried A1 - Zylla, Birgitta A1 - Niproschke, Saskia A1 - Guder, Petra A1 - Sonnen, Bernd-Rüdeger A1 - Kahl, Wolfgang A1 - Groeger-Roth, Frederick A1 - Kaeding, Peer A1 - Böhm, Christian A1 - Voigt, Jana A1 - Sturzbecher, Dietmar A1 - Kohlstruck, Michael A1 - Möller, Kurt A1 - Rolfes, Manfred A1 - Winter, Frank A1 - Breitschwerdt, Michael A1 - Kopp, Andrea A1 - Hinze, Klaus A1 - Lösel, Friedrich A1 - Klindworth-Mohr, Antje A1 - Madl, Martina A1 - Dunand, Annelie A1 - Schanzenbächer, Stefan A1 - Rump-Räuber, Michael A1 - Roos, Alfred A1 - Seidel, Andreas A1 - Gröger, Ulli A1 - Ulbricht, Juliane A1 - Martin, Christian A1 - Behrendt, Daniel ED - Schubarth, Wilfried T1 - Nachhaltige Prävention von Kriminalität, Gewalt und Rechtsextremismus BT - Beiträge aus Wissenschaft und Praxis N2 - Was wird unter „nachhaltiger Prävention“ in der Präventionsforschung verstanden? Welche guten Beispiele für nachhaltige Prävention gibt es in der Praxis? Und v. a.: Wie lässt sich Prävention in den verschiedenen Bereichen wie Kriminalität, Gewalt und Rechtsextremismus nachhaltig gestalten? Diesen Fragen will der vorliegende Sammelband nachgehen und damit der Präventionsdebatte neue Impulse verleihen. Der Band will insbesondere die nationale sowie internationale Fachdebatte konstruktiv aufgreifen, Theorie und Praxis verbinden, „good practice“ Beispiele darstellen sowie Perspektiven nachhaltiger Prävention aufzeigen. Mit diesem Themenspektrum richtet er sich sowohl an die Wissenschaft als auch an die Praxis sowie insgesamt an eine interessierte Öffentlichkeit. N2 - What is meant by „sustainable prevention“ in prevention research? What are good examples for sustainable prevention? And above all: How can prevention in fields like crime, violence and right-wing extremism be arranged sustainably? This miscellany is focused on these questions and it is intend to give new inputs for the current discussion on sustainable prevention. Especially, the miscellany is meant to connect the national and international trade debate, to combine theory and practice, to describe examples of “good practice” as well as to show prospects of sustainable prevention. These range of topics focus on science and practice as well as an interested public in general. KW - Prävention KW - Nachhaltigkeit KW - Gewalt KW - Kriminalität KW - Rechtsextremismus KW - prevention KW - sustainability KW - violence KW - crime KW - right-wing extremism Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-70537 SN - 978-3-86956-014-4 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Voigt, Bernd A1 - Krikunova, Maria A1 - Lokstein, Heiko T1 - Influence of detergent concentration on aggregation and the spectroscopic properties of light-harvesting complex II Y1 - 2008 U6 - https://doi.org/10.1007/s11120-007-9250-5 ER - TY - JOUR A1 - Lokstein, Heiko A1 - Betke, Alexander A1 - Krikunova, Maria A1 - Teuchner, Klaus A1 - Voigt, Bernd T1 - Elucidation of structure-function relationships in plant major light-harvesting complex (LHC II) by nonlinear spectroscopy JF - Photosynthesis research N2 - Conventional linear and time-resolved spectroscopic techniques are often not appropriate to elucidate specific pigment-pigment interactions in light-harvesting pigment-protein complexes (LHCs). Nonlinear (laser-) spectroscopic techniques, including nonlinear polarization spectroscopy in the frequency domain (NLPF) as well as step-wise (resonant) and simultaneous (non-resonant) two-photon excitation spectroscopies may be advantageous in this regard. Nonlinear spectroscopies have been used to elucidate substructure(s) of very complex spectra, including analyses of strong excitonic couplings between chlorophylls and of interactions between (bacterio) chlorophylls and "optically dark'' states of carotenoids in LHCs, including the major antenna complex of higher plants, LHC II. This article shortly reviews our previous study and outlines perspectives regarding the application of selected nonlinear laser-spectroscopic techniques to disentangle structure-function relationships in LHCs and other pigment-protein complexes. KW - Excitonic interactions KW - Laser spectroscopy KW - Light-harvesting complex (LHC II) Y1 - 2012 U6 - https://doi.org/10.1007/s11120-011-9700-y SN - 0166-8595 VL - 111 IS - 1-2 SP - 227 EP - 235 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Lokstein, Heiko A1 - Krikunova, Maria A1 - Teuchner, Klaus A1 - Voigt, Bernd T1 - Elucidation of structure-function relationships in photosynthetic light-harvesting antenna complexes by non-linear polarization spectroscopy in the frequency domain (NLPF) JF - Journal of plant physiology : biochemistry, physiology, molecular biology and biotechnology of plants N2 - Photosynthetically active pigments are usually organized into pigment-protein complexes. These include light-harvesting antenna complexes (LHCs) and reaction centers. Site energies of the bound pigments are determined by interactions with their environment, i.e., by pigment-protein as well as pigment-pigment interactions. Thus, resolution of spectral substructures of the pigment-protein complexes may provide valuable insight into structure-function relationships. By means of conventional (linear) and time-resolved spectroscopic techniques, however, it is often difficult to resolve the spectral substructures of complex pigment-protein assemblies. Nonlinear polarization spectroscopy in the frequency domain (NLPF) is shown to be a valuable technique in this regard. Based on initial experimental work with purple bacterial antenna complexes as well as model systems NLPF has been extended to analyse the substructure(s) of very complex spectra, including analyses of interactions between chlorophylls and "optically dark" states of carotenoids in LHCs. The paper reviews previous work and outlines perspectives regarding the application of NLPF spectroscopy to disentangle structure-function relationships in pigment-protein complexes. KW - Excitonic interactions KW - Laser spectroscopy KW - Light-harvesting complex KW - Nonlinear polarization spectroscopy in the frequency domain KW - Pigment-pigment interactions Y1 - 2011 U6 - https://doi.org/10.1016/j.jplph.2010.12.012 SN - 0176-1617 VL - 168 IS - 12 SP - 1488 EP - 1496 PB - Elsevier CY - Jena ER - TY - JOUR A1 - Grawert, Achim A1 - Wagner, Dieter A1 - Voigt, Bernd-Friedrich T1 - Flexibilisierung und Individualisierung von Vergütungs- und Arbeitszeitsystemen Y1 - 2003 ER -