TY  - JOUR
A1  - Toulouse, Charlotte Marguerite
A1  - Schmucker, Sonja
A1  - Metesch, Kristina
A1  - Pfannstiel, Jens
A1  - Michel, Bernd
A1  - Starke, Ines
A1  - Möller, Heiko Michael
A1  - Stefanski, Volker
A1  - Steuber, Julia
T1  - Mechanism and impact of catecholamine conversion by Vibrio cholerae
JF  - Biochimica et biophysica acta : Bioenergetics
N2  - Bacterial pathogens are influenced by signaling molecules including the catecholamines adrenaline and noradrenaline which are host-derived hormones and neurotransmitters. Adrenaline and noradrenaline modulate growth, motility and virulence of bacteria. We show that adrenaline is converted by the pathogen Vibrio cholerae to adrenochrome in the course of respiration, and demonstrate that superoxide produced by the respiratory, Na+ - translocating NADH:quinone oxidoreductase (NQR) acts as electron acceptor in the oxidative conversion of adrenaline to adrenochrome. Adrenochrome stimulates growth of V. cholerae, and triggers specific responses in V. cholerae and in immune cells. We performed a quantitative proteome analysis of V. cholerae grown in minimal medium with glucose as carbon source without catecholamines, or with adrenaline, noradrenaline or adrenochrome. Significant regulation of proteins participating in iron transport and iron homeostasis, in energy metabolism, and in signaling was observed upon exposure to adrenaline, noradrenaline or adrenochrome. On the host side, adrenochrome inhibited lipopolysaccharide-triggered formation of TNF-alpha by THP-1 monocytes, though to a lesser extent than adrenaline. It is proposed that adrenochrome produced from adrenaline by respiring V. cholerae functions as effector molecule in pathogen-host interaction.
KW  - Vibrio cholerae
KW  - Na+ - NADH:quinone oxidoreductase
KW  - NQR
KW  - Superoxide
KW  - Adrenaline
KW  - Adrenochrome
Y1  - 2019
U6  - https://doi.org/10.1016/j.bbabio.2019.04.003
SN  - 0005-2728
SN  - 1879-2650
VL  - 1860
IS  - 6
SP  - 478
EP  - 487
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Read, Betsy A.
A1  - Kegel, Jessica
A1  - Klute, Mary J.
A1  - Kuo, Alan
A1  - Lefebvre, Stephane C.
A1  - Maumus, Florian
A1  - Mayer, Christoph
A1  - Miller, John
A1  - Monier, Adam
A1  - Salamov, Asaf
A1  - Young, Jeremy
A1  - Aguilar, Maria
A1  - Claverie, Jean-Michel
A1  - Frickenhaus, Stephan
A1  - Gonzalez, Karina
A1  - Herman, Emily K.
A1  - Lin, Yao-Cheng
A1  - Napier, Johnathan
A1  - Ogata, Hiroyuki
A1  - Sarno, Analissa F.
A1  - Shmutz, Jeremy
A1  - Schroeder, Declan
A1  - de Vargas, Colomban
A1  - Verret, Frederic
A1  - von Dassow, Peter
A1  - Valentin, Klaus
A1  - Van de Peer, Yves
A1  - Wheeler, Glen
A1  - Dacks, Joel B.
A1  - Delwiche, Charles F.
A1  - Dyhrman, Sonya T.
A1  - Glöckner, Gernot
A1  - John, Uwe
A1  - Richards, Thomas
A1  - Worden, Alexandra Z.
A1  - Zhang, Xiaoyu
A1  - Grigoriev, Igor V.
A1  - Allen, Andrew E.
A1  - Bidle, Kay
A1  - Borodovsky, M.
A1  - Bowler, C.
A1  - Brownlee, Colin
A1  - Cock, J. Mark
A1  - Elias, Marek
A1  - Gladyshev, Vadim N.
A1  - Groth, Marco
A1  - Guda, Chittibabu
A1  - Hadaegh, Ahmad
A1  - Iglesias-Rodriguez, Maria Debora
A1  - Jenkins, J.
A1  - Jones, Bethan M.
A1  - Lawson, Tracy
A1  - Leese, Florian
A1  - Lindquist, Erika
A1  - Lobanov, Alexei
A1  - Lomsadze, Alexandre
A1  - Malik, Shehre-Banoo
A1  - Marsh, Mary E.
A1  - Mackinder, Luke
A1  - Mock, Thomas
A1  - Müller-Röber, Bernd
A1  - Pagarete, Antonio
A1  - Parker, Micaela
A1  - Probert, Ian
A1  - Quesneville, Hadi
A1  - Raines, Christine
A1  - Rensing, Stefan A.
A1  - Riano-Pachon, Diego Mauricio
A1  - Richier, Sophie
A1  - Rokitta, Sebastian
A1  - Shiraiwa, Yoshihiro
A1  - Soanes, Darren M.
A1  - van der Giezen, Mark
A1  - Wahlund, Thomas M.
A1  - Williams, Bryony
A1  - Wilson, Willie
A1  - Wolfe, Gordon
A1  - Wurch, Louie L.
T1  - Pan genome of the phytoplankton Emiliania underpins its global distribution
JF  - Nature : the international weekly journal of science
N2  - Coccolithophores have influenced the global climate for over 200 million years(1). These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems(2). They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering them visible from space(3). Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean(4). Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate that E. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions.
Y1  - 2013
U6  - https://doi.org/10.1038/nature12221
SN  - 0028-0836
SN  - 1476-4687
VL  - 499
IS  - 7457
SP  - 209
EP  - 213
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - GEN
A1  - Biskaborn, Boris
A1  - Smith, Sharon L.
A1  - Noetzli, Jeannette
A1  - Matthes, Heidrun
A1  - Vieira, Gonçalo
A1  - Streletskiy, Dmitry A.
A1  - Schoeneich, Philippe
A1  - Romanovsky, Vladimir E.
A1  - Lewkowicz, Antoni G.
A1  - Abramov, Andrey
A1  - Allard, Michel
A1  - Boike, Julia
A1  - Cable, William L.
A1  - Christiansen, Hanne H.
A1  - Delaloye, Reynald
A1  - Diekmann, Bernhard
A1  - Drozdov, Dmitry
A1  - Etzelmüller, Bernd
A1  - Große, Guido
A1  - Guglielmin, Mauro
A1  - Ingeman-Nielsen, Thomas
A1  - Isaksen, Ketil
A1  - Ishikawa, Mamoru
A1  - Johansson, Margareta
A1  - Joo, Anseok
A1  - Kaverin, Dmitry
A1  - Kholodov, Alexander
A1  - Konstantinov, Pavel
A1  - Kröger, Tim
A1  - Lambiel, Christophe
A1  - Lanckman, Jean-Pierre
A1  - Luo, Dongliang
A1  - Malkova, Galina
A1  - Meiklejohn, Ian
A1  - Moskalenko, Natalia
A1  - Oliva, Marc
A1  - Phillips, Marcia
A1  - Ramos, Miguel
A1  - Sannel, A. Britta K.
A1  - Sergeev, Dmitrii
A1  - Seybold, Cathy
A1  - Skryabin, Pavel
A1  - Vasiliev, Alexander
A1  - Wu, Qingbai
A1  - Yoshikawa, Kenji
A1  - Zheleznyak, Mikhail
A1  - Lantuit, Hugues
T1  - Permafrost is warming at a global scale
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Permafrost warming has the potential to amplify global climate change, because when frozen sediments thaw it unlocks soil organic carbon. Yet to date, no globally consistent assessment of permafrost temperature change has been compiled. Here we use a global data set of permafrost temperature time series from the Global Terrestrial Network for Permafrost to evaluate temperature change across permafrost regions for the period since the International Polar Year (2007–2009). During the reference decade between 2007 and 2016, ground temperature near the depth of zero annual amplitude in the continuous permafrost zone increased by 0.39 ± 0.15 °C. Over the same period, discontinuous permafrost warmed by 0.20 ± 0.10 °C. Permafrost in mountains warmed by 0.19 ± 0.05 °C and in Antarctica by 0.37 ± 0.10 °C. Globally, permafrost temperature increased by 0.29 ± 0.12 °C. The observed trend follows the Arctic amplification of air temperature increase in the Northern Hemisphere. In the discontinuous zone, however, ground warming occurred due to increased snow thickness while air temperature remained statistically unchanged.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 669 
KW  - seasonal snow cover
KW  - thermal state
KW  - climate-change
KW  - activ-layer
KW  - Antarctic Peninsula
KW  - stability
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-425341
SN  - 1866-8372
IS  - 669
ER  - 
TY  - JOUR
A1  - Biskaborn, Boris
A1  - Smith, Sharon L.
A1  - Noetzli, Jeannette
A1  - Matthes, Heidrun
A1  - Vieira, Goncalo
A1  - Streletskiy, Dmitry A.
A1  - Schoeneich, Philippe
A1  - Romanovsky, Vladimir E.
A1  - Lewkowicz, Antoni G.
A1  - Abramov, Andrey
A1  - Allard, Michel
A1  - Boike, Julia
A1  - Cable, William L.
A1  - Christiansen, Hanne H.
A1  - Delaloye, Reynald
A1  - Diekmann, Bernhard
A1  - Drozdov, Dmitry
A1  - Etzelmueller, Bernd
A1  - Grosse, Guido
A1  - Guglielmin, Mauro
A1  - Ingeman-Nielsen, Thomas
A1  - Isaksen, Ketil
A1  - Ishikawa, Mamoru
A1  - Johansson, Margareta
A1  - Johannsson, Halldor
A1  - Joo, Anseok
A1  - Kaverin, Dmitry
A1  - Kholodov, Alexander
A1  - Konstantinov, Pavel
A1  - Kroeger, Tim
A1  - Lambiel, Christophe
A1  - Lanckman, Jean-Pierre
A1  - Luo, Dongliang
A1  - Malkova, Galina
A1  - Meiklejohn, Ian
A1  - Moskalenko, Natalia
A1  - Oliva, Marc
A1  - Phillips, Marcia
A1  - Ramos, Miguel
A1  - Sannel, A. Britta K.
A1  - Sergeev, Dmitrii
A1  - Seybold, Cathy
A1  - Skryabin, Pavel
A1  - Vasiliev, Alexander
A1  - Wu, Qingbai
A1  - Yoshikawa, Kenji
A1  - Zheleznyak, Mikhail
A1  - Lantuit, Hugues
T1  - Permafrost is warming at a global scale
JF  - Nature Communications
N2  - Permafrost warming has the potential to amplify global climate change, because when frozen sediments thaw it unlocks soil organic carbon. Yet to date, no globally consistent assessment of permafrost temperature change has been compiled. Here we use a global data set of permafrost temperature time series from the Global Terrestrial Network for Permafrost to evaluate temperature change across permafrost regions for the period since the International Polar Year (2007-2009). During the reference decade between 2007 and 2016, ground temperature near the depth of zero annual amplitude in the continuous permafrost zone increased by 0.39 +/- 0.15 degrees C. Over the same period, discontinuous permafrost warmed by 0.20 +/- 0.10 degrees C. Permafrost in mountains warmed by 0.19 +/- 0.05 degrees C and in Antarctica by 0.37 +/- 0.10 degrees C. Globally, permafrost temperature increased by 0.29 +/- 0.12 degrees C. The observed trend follows the Arctic amplification of air temperature increase in the Northern Hemisphere. In the discontinuous zone, however, ground warming occurred due to increased snow thickness while air temperature remained statistically unchanged.
Y1  - 2019
U6  - https://doi.org/10.1038/s41467-018-08240-4
SN  - 2041-1723
VL  - 10
PB  - Nature Publ. Group
CY  - London
ER  -