TY  - JOUR
A1  - Diekmann, Martin
A1  - Andres, Christian
A1  - Becker, Thomas
A1  - Bennie, Jonathan
A1  - Blueml, Volker
A1  - Bullock, James M.
A1  - Culmsee, Heike
A1  - Fanigliulo, Miriam
A1  - Hahn, Annett
A1  - Heinken, Thilo
A1  - Leuschner, Christoph
A1  - Luka, Stefanie
A1  - Meissner, Justus
A1  - Müller, Josef
A1  - Newton, Adrian
A1  - Peppler-Lisbach, Cord
A1  - Rosenthal, Gert
A1  - van den Berg, Leon J. L.
A1  - Vergeer, Philippine
A1  - Wesche, Karsten
T1  - Patterns of long-term vegetation change vary between different types of semi-natural grasslands in Western and Central Europe
JF  - Journal of vegetation science
N2  - Questions Has plant species richness in semi-natural grasslands changed over recent decades? Do the temporal trends of habitat specialists differ from those of habitat generalists? Has there been a homogenization of the grassland vegetation? Location Different regions in Germany and the UK. Methods We conducted a formal meta-analysis of re-survey vegetation studies of semi-natural grasslands. In total, 23 data sets were compiled, spanning up to 75 years between the surveys, including 13 data sets from wet grasslands, six from dry grasslands and four from other grassland types. Edaphic conditions were assessed using mean Ellenberg indicator values for soil moisture, nitrogen and pH. Changes in species richness and environmental variables were evaluated using response ratios. Results In most wet grasslands, total species richness declined over time, while habitat specialists almost completely vanished. The number of species losses increased with increasing time between the surveys and were associated with a strong decrease in soil moisture and higher soil nutrient contents. Wet grasslands in nature reserves showed no such changes or even opposite trends. In dry grasslands and other grassland types, total species richness did not consistently change, but the number or proportions of habitat specialists declined. There were also considerable changes in species composition, especially in wet grasslands that often have been converted into intensively managed, highly productive meadows or pastures. We did not find a general homogenization of the vegetation in any of the grassland types. Conclusions The results document the widespread deterioration of semi-natural grasslands, especially of those types that can easily be transformed to high production grasslands. The main causes for the loss of grassland specialists are changed management in combination with increased fertilization and nitrogen deposition. Dry grasslands are most resistant to change, but also show a long-term trend towards an increase in more mesotrophic species.
KW  - dry grasslands
KW  - fragmentation
KW  - homogenization
KW  - management
KW  - meta-analysis
KW  - nitrogen deposition
KW  - quasi-permanent plot
KW  - re-survey
KW  - species richness
KW  - wet grasslands
Y1  - 2019
U6  - https://doi.org/10.1111/jvs.12727
SN  - 1100-9233
SN  - 1654-1103
VL  - 30
IS  - 2
SP  - 187
EP  - 202
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Stoessel, Daniel
A1  - Schulte, Claudia
A1  - dos Santos, Marcia C. Teixeira
A1  - Scheller, Dieter
A1  - Rebollo-Mesa, Irene
A1  - Deuschle, Christian
A1  - Walther, Dirk
A1  - Schauer, Nicolas
A1  - Berg, Daniela
A1  - da Costa, Andre Nogueira
A1  - Maetzler, Walter
T1  - Promising Metabolite Profiles in the Plasma and CSF of Early Clinical
JF  - Frontiers in Aging Neuroscience
N2  - Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics allows establishing low-molecular compound biomarkers in a wide range of complex diseases by the measurement of various molecular classes in biofluids such as blood plasma, serum, and cerebrospinal fluid (CSF). Here, we applied untargeted high-resolution mass spectrometry to determine plasma and CSF metabolite profiles. We semiquantitatively determined small-molecule levels (<= 1.5 kDa) in the plasma and CSF from early PD patients (disease duration 0-4 years; n = 80 and 40, respectively), and sex-and age-matched controls (n = 76 and 38, respectively). We performed statistical analyses utilizing partial least square and random forest analysis with a 70/30 training and testing split approach, leading to the identification of 20 promising plasma and 14 CSF metabolites. The semetabolites differentiated the test set with an AUC of 0.8 (plasma) and 0.9 (CSF). Characteristics of the metabolites indicate perturbations in the glycerophospholipid, sphingolipid, and amino acid metabolism in PD, which underscores the high power of metabolomic approaches. Further studies will enable to develop a potential metabolite-based biomarker panel specific for PD
KW  - biomarker
KW  - untargeted metabolomics
KW  - neurodegeneration
KW  - plasma
KW  - CSF
KW  - machinelearning
Y1  - 2018
U6  - https://doi.org/10.3389/fnagi.2018.00051
SN  - 1663-4365
VL  - 10
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - CHAP
A1  - Heinisch, Isabelle
A1  - Romeike, Ralf
A1  - Knobelsdorf, Maria
A1  - Kreitz, Christoph
A1  - Nylén, Aletta
A1  - Dörge, Christina
A1  - Göttel, Timo
A1  - Holz, Jan
A1  - Bergner, Nadine
A1  - Schroeder, Ulrik
A1  - Metzger, Christiane
A1  - Haag, Johann
A1  - Abke, Jörg
A1  - Schwirtlich, Vincent
A1  - Sedelmaier, Yvonne
A1  - Müller, Dorothee
A1  - Frommer, Andreas
A1  - Humbert, Ludger
A1  - Berges, Marc
A1  - Mühling, Andreas
A1  - Hubwieser, Peter
A1  - Steuer, Horst
A1  - Engbring, Dieter
A1  - Selke, Harald
A1  - Drews, Paul
A1  - Schirmer, Ingrid
A1  - Morisse, Marcel
A1  - Sagawe, Arno
A1  - Rolf, Arno
A1  - Friedemann, Stefan
A1  - Gröger, Stefan
A1  - Schumann, Matthias
A1  - Klinger, Melanie
A1  - Polutina, Olena
A1  - Bibel, Ariane
A1  - Götz, Christian
A1  - Brinda, Torsten
A1  - Apel, Rebecca
A1  - Berg, Tobias
A1  - Bergner, Nadine
A1  - Chatti, Mohamed Amine
A1  - Leicht-Scholten, Carmen
A1  - Schroeder, Ulrik
A1  - Al-Saffar, Loay Talib
A1  - Petre, Marian
A1  - Schirmer, Ingrid
A1  - Rick, Detlef
ED  - Forbrig, Peter
ED  - Rick, Detlef
ED  - Schmolitzky, Axel
T1  - HDI 2012 – Informatik für eine nachhaltige Zukunft : 5. Fachtagung Hochschuldidaktik der Informatik ; 06.–07. November 2012, Universität Hamburg
N2  - Die Tagungsreihe zur Hochschuldidaktik der Informatik HDI wird vom Fachbereich Informatik und Ausbildung / Didaktik der Informatik (IAD) in der Gesellschaft für Informatik e. V. (GI) organisiert. Sie dient den Lehrenden der Informatik in Studiengängen an Hochschulen als Forum der Information und des Austauschs über neue didaktische Ansätze und bildungspolitische Themen im Bereich der Hochschulausbildung aus der fachlichen Perspektive der Informatik. Diese fünfte HDI 2012 wurde an der Universität Hamburg organisiert. Für sie wurde das spezielle Motto „Informatik für eine nachhaltige Zukunft“ gewählt, um insbesondere Fragen der Bildungsrelevanz informatischer Inhalte, der Kompetenzen für Studierende informatisch geprägter Studiengänge und der Rolle der Informatik in der Hochschulentwicklung zu diskutieren.
T3  - Commentarii informaticae didacticae (CID) - 5 
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-62891
SN  - 978-3-86956-220-9
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Stoessel, Daniel
A1  - Stellmann, Jan-Patrick
A1  - Willing, Anne
A1  - Behrens, Birte
A1  - Rosenkranz, Sina C.
A1  - Hodecker, Sibylle C.
A1  - Stuerner, Klarissa H.
A1  - Reinhardt, Stefanie
A1  - Fleischer, Sabine
A1  - Deuschle, Christian
A1  - Maetzler, Walter
A1  - Berg, Daniela
A1  - Heesen, Christoph
A1  - Walther, Dirk
A1  - Schauer, Nicolas
A1  - Friese, Manuel A.
A1  - Pless, Ole
T1  - Metabolomic Profiles for Primary Progressive Multiple Sclerosis Stratification and Disease Course Monitoring
JF  - Frontiers in human neuroscienc
N2  - Primary progressive multiple sclerosis (PPMS) shows a highly variable disease progression with poor prognosis and a characteristic accumulation of disabilities in patients. These hallmarks of PPMS make it difficult to diagnose and currently impossible to efficiently treat. This study aimed to identify plasma metabolite profiles that allow diagnosis of PPMS and its differentiation from the relapsing remitting subtype (RRMS), primary neurodegenerative disease (Parkinson’s disease, PD), and healthy controls (HCs) and that significantly change during the disease course and could serve as surrogate markers of multiple sclerosis (MS)-associated neurodegeneration over time. We applied untargeted high-resolution metabolomics to plasma samples to identify PPMS-specific signatures, validated our findings in independent sex- and age-matched PPMS and HC cohorts and built discriminatory models by partial least square discriminant analysis (PLS-DA). This signature was compared to sex- and age-matched RRMS patients, to patients with PD and HC. Finally, we investigated these metabolites in a longitudinal cohort of PPMS patients over a 24-month period. PLS-DA yielded predictive models for classification along with a set of 20 PPMS-specific informative metabolite markers. These metabolites suggest disease-specific alterations in glycerophospholipid and linoleic acid pathways. Notably, the glycerophospholipid LysoPC(20:0) significantly decreased during the observation period. These findings show potential for diagnosis and disease course monitoring, and might serve as biomarkers to assess treatment efficacy in future clinical trials for neuroprotective MS therapies.
KW  - untargeted metabolomics
KW  - biomarker
KW  - PPMS
KW  - MS neurodegeneration
KW  - LysoPC(20:0)
Y1  - 2018
U6  - https://doi.org/10.3389/fnhum.2018.00226
SN  - 1662-5161
VL  - 12
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Berg, Christian
A1  - Bilz, Melanie
A1  - Ristow, Michael
A1  - Raab, Bernd
T1  - Important Plant Areas (IPA) : ein internationales Konzept zum Schutz der Wildpflanzen der Erde
Y1  - 2008
ER  - 
TY  - JOUR
A1  - Kern, Jürgen
A1  - Hellebrand, Hans Jürgen
A1  - Gömmel, Michael
A1  - Ammon, Christian
A1  - Berg, Werner
T1  - Effects of climatic factors and soil management on the methane flux in soils from annual and perennial energy crops
JF  - Biology and fertility of soils
N2  - Methane flux rates were measured on a loamy sand soil within perennial and annual energy crops in northeast Germany. The study was performed in closed chambers between 2003 and 2005 with four measurements per week. A mixed linear model including the fixed effects of year, rotation period, crop and fertilisation was applied to determine the influence of climatic factors and soil management on the CH4 flux. Soil water content and air temperature were added as co-variables. With the exception of air temperature, all fixed effects and the co-variable soil water content influenced the CH4 flux. The soil of annual crops consumed 6.1 mu g CH4 m(-2) h(-1), significantly more than the soil of perennial crops with 4.3 mu g CH4 m(-2) h(-1). It is suggested that soil water content plays the key role in CH4 flux between pedosphere and atmosphere. In the range of water contents between 5% and 15%, our model describes that a soil water content increase of 1% induces a net emission of 0.375 mu g CH4 m(-2) h(-1). As the soil of the experimental field was well-drained and aerobic, it represented a net sink for CH4 throughout the study period.
KW  - Methane oxidation
KW  - ANCOVA model
KW  - Soil water
KW  - Fertilisation
KW  - Greenhouse gases
KW  - Energy crops
Y1  - 2012
U6  - https://doi.org/10.1007/s00374-011-0603-z
SN  - 0178-2762
VL  - 48
IS  - 1
SP  - 1
EP  - 8
PB  - Springer
CY  - New York
ER  - 
TY  - GEN
A1  - Stoessel, Daniel
A1  - Stellmann, Jan-Patrick
A1  - Willing, Anne
A1  - Behrens, Birte
A1  - Rosenkranz, Sina C.
A1  - Hodecker, Sibylle C.
A1  - Stürner, Klarissa H.
A1  - Reinhardt, Stefanie
A1  - Fleischer, Sabine
A1  - Deuschle, Christian
A1  - Maetzler, Walter
A1  - Berg, Daniela
A1  - Heesen, Christoph
A1  - Walther, Dirk
A1  - Schauer, Nicolas
A1  - Friese, Manuel A.
A1  - Pless, Ole
T1  - Metabolomic profiles for primary progressive multiple sclerosis stratification and disease course monitoring
T2  - Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe
N2  - Primary progressive multiple sclerosis (PPMS) shows a highly variable disease progression with poor prognosis and a characteristic accumulation of disabilities in patients. These hallmarks of PPMS make it difficult to diagnose and currently impossible to efficiently treat. This study aimed to identify plasma metabolite profiles that allow diagnosis of PPMS and its differentiation from the relapsing remitting subtype (RRMS), primary neurodegenerative disease (Parkinson’s disease, PD), and healthy controls (HCs) and that significantly change during the disease course and could serve as surrogate markers of multiple sclerosis (MS)-associated neurodegeneration over time. We applied untargeted high-resolution metabolomics to plasma samples to identify PPMS-specific signatures, validated our findings in independent sex- and age-matched PPMS and HC cohorts and built discriminatory models by partial least square discriminant analysis (PLS-DA). This signature was compared to sex- and age-matched RRMS patients, to patients with PD and HC. Finally, we investigated these metabolites in a longitudinal cohort of PPMS patients over a 24-month period. PLS-DA yielded predictive models for classification along with a set of 20 PPMS-specific informative metabolite markers. These metabolites suggest disease-specific alterations in glycerophospholipid and linoleic acid pathways. Notably, the glycerophospholipid LysoPC(20:0) significantly decreased during the observation period. These findings show potential for diagnosis and disease course monitoring, and might serve as biomarkers to assess treatment efficacy in future clinical trials for neuroprotective MS therapies.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 694 
KW  - untargeted metabolomics
KW  - biomarker
KW  - PPMS
KW  - MS neurodegeneration
KW  - LysoPC(20:0)
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-426307
SN  - 1866-8372
IS  - 694
ER  - 
TY  - BOOK
A1  - Wiemann, Dirk
A1  - Emig, Rainer
A1  - Schmitt-Kilb, Christian
A1  - Stedman, Gesa
A1  - Berg, Sebastian
T1  - Journal for the Study of British Cultures
Y1  - 2010
SN  - 0944-9094
PB  - Königshausen & Neumann GmbH
CY  - Würzburg
ER  - 
TY  - JOUR
A1  - Havinga, Reinout
A1  - Kool, Anneleen
A1  - Achille, Frederic
A1  - Bavcon, Joze
A1  - Berg, Christian
A1  - Bonomi, Costantino
A1  - Burkart, Michael
A1  - De Meyere, Dirk
A1  - Havstrom, Mats
A1  - Kessler, Paul
A1  - Knickmann, Barbara
A1  - Koester, Nils
A1  - Martinez, Remy
A1  - Ostgaard, Havard
A1  - Ravnjak, Blanka
A1  - Scheen, Anne-Cathrine
A1  - Smith, Pamela
A1  - Smith, Paul
A1  - Socher, Stephanie A.
A1  - Vange, Vibekke
T1  - The Index Seminum: Seeds of change for seed exchange
JF  - Taxon
N2  - Botanic gardens have been exchanging seeds through seed catalogues for centuries. In many gardens, these catalogues remain an important source of plant material. Living collections have become more relevant for genetic analysis and derived research, since genomics of non-model organisms heavily rely on living material. The range of species that is made available annually on all seed lists combined, provides an unsurpassed source of instantly accessible plant material for research collections. Still, the Index Seminum has received criticism in the past few decades. The current exchange model dictates that associated data is manually entered into each database. The amount of time involved and the human errors occurring in this process are difficult to justify when the data was initially produced as a report from another database. The authors propose that an online marketplace for seed exchange should be established, with enhanced search possibilities and downloadable accession data in a standardised format. Such online service should preferably be supervised and coordinated by Botanic Gardens Conservation International (BGCI). This manuscript is the outcome of a workshop on July 9th, 2015, at the European botanic gardens congress "Eurogard VII" in Paris, where the first two authors invited members of the botanic garden community to discuss how the anachronistic Index Seminum can be transformed into an improved and modern tool for seed exchange.
KW  - database
KW  - Index Seminum
KW  - information technology
KW  - living collections management
KW  - Nagoya-protocol
KW  - seed exchange
Y1  - 2016
U6  - https://doi.org/10.12705/652.9
SN  - 0040-0262
SN  - 1996-8175
VL  - 65
SP  - 333
EP  - 336
PB  - International Association for Plant Taxonomy
CY  - Bratislava
ER  -