TY - JOUR A1 - Graja, Antonia A1 - Garcia-Carrizo, Francisco A1 - Jank, Anne-Marie A1 - Gohlke, Sabrina A1 - Ambrosi, Thomas H. A1 - Jonas, Wenke A1 - Ussar, Siegfried A1 - Kern, Matthias A1 - Schürmann, Annette A1 - Aleksandrova, Krasimira A1 - Bluher, Matthias A1 - Schulz, Tim Julius T1 - Loss of periostin occurs in aging adipose tissue of mice and its genetic ablation impairs adipose tissue lipid metabolism JF - Aging Cell N2 - Remodeling of the extracellular matrix is a key component of the metabolic adaptations of adipose tissue in response to dietary and physiological challenges. Disruption of its integrity is a well-known aspect of adipose tissue dysfunction, for instance, during aging and obesity. Adipocyte regeneration from a tissue-resident pool of mesenchymal stem cells is part of normal tissue homeostasis. Among the pathophysiological consequences of adipogenic stem cell aging, characteristic changes in the secretory phenotype, which includes matrix-modifying proteins, have been described. Here, we show that the expression of the matricellular protein periostin, a component of the extracellular matrix produced and secreted by adipose tissue-resident interstitial cells, is markedly decreased in aged brown and white adipose tissue depots. Using a mouse model, we demonstrate that the adaptation of adipose tissue to adrenergic stimulation and high-fat diet feeding is impaired in animals with systemic ablation of the gene encoding for periostin. Our data suggest that loss of periostin attenuates lipid metabolism in adipose tissue, thus recapitulating one aspect of age-related metabolic dysfunction. In human white adipose tissue, periostin expression showed an unexpected positive correlation with age of study participants. This correlation, however, was no longer evident after adjusting for BMI or plasma lipid and liver function biomarkers. These findings taken together suggest that age-related alterations of the adipose tissue extracellular matrix may contribute to the development of metabolic disease by negatively affecting nutrient homeostasis. KW - adipogenic progenitor cells KW - adipose tissue KW - aging KW - extracellular matrix KW - fatty acid metabolism KW - periostin Y1 - 2018 U6 - https://doi.org/10.1111/acel.12810 SN - 1474-9718 SN - 1474-9726 VL - 17 IS - 5 PB - Wiley CY - Hoboken ER - TY - THES A1 - Kern, Anne T1 - Juana Borrero BT - Choreografien einer Künstlerin T2 - Mimesis N2 - Juana Borrero y Pierra (1877–1896) war eine der wichtigsten Vertreterinnen des inselkubanischen Modernismo. Gleichwohl ist das Schaffen der schon zu Lebzeiten zum Wunderkind stilisierten Autorin, Dichterin und Malerin wissenschaftlich kaum eingehender untersucht worden. Die Werkstudie schlägt einen umfassenden, konsequent ästhetischen Blick auf das aus Gedichten, poetischer Prosa, literarischen Liebesbriefen, Zeichnungen und Malereien bestehende Gesamtwerk Borreros vor, das im Kern ein Streben nach Ganzheit von Kunst und Leben offenlegt. Dabei werden die Text- und Bildstrategien der Künstlerin mit den ästhetischen, soziohistorischen und biografischen Kontexten verzahnt, wodurch Juana Borreros Stimme als exemplarische Stimme der kubanischen Spätmoderne sowie einer bewegten kubanischen Literatur les- und sichtbar wird. KW - Modernismo KW - Biographie KW - Kubanische Literatur KW - Borrero, Juana Y1 - 2023 SN - 978-3-11-074835-2 SN - 978-3-11-074857-4 SN - 978-3-11-074849-9 U6 - https://doi.org/10.1515/9783110748499 SN - 0178-7489 VL - 93 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Kokhanovsky, Alexander A1 - Lamare, Maxim A1 - Danne, Olaf A1 - Brockmann, Carsten A1 - Dumont, Marie A1 - Picard, Ghislain A1 - Arnaud, Laurent A1 - Favier, Vincent A1 - Jourdain, Bruno A1 - Le Meur, Emmanuel A1 - Di Mauro, Biagio A1 - Aoki, Teruo A1 - Niwano, Masashi A1 - Rozanov, Vladimir A1 - Korkin, Sergey A1 - Kipfstuhl, Sepp A1 - Freitag, Johannes A1 - Hoerhold, Maria A1 - Zuhr, Alexandra A1 - Vladimirova, Diana A1 - Faber, Anne-Katrine A1 - Steen-Larsen, Hans Christian A1 - Wahl, Sonja A1 - Andersen, Jonas K. A1 - Vandecrux, Baptiste A1 - van As, Dirk A1 - Mankoff, Kenneth D. A1 - Kern, Michael A1 - Zege, Eleonora A1 - Box, Jason E. T1 - Retrieval of Snow Properties from the Sentinel-3 Ocean and Land Colour Instrument JF - Remote sensing N2 - The Sentinel Application Platform (SNAP) architecture facilitates Earth Observation data processing. In this work, we present results from a new Snow Processor for SNAP. We also describe physical principles behind the developed snow property retrieval technique based on the analysis of Ocean and Land Colour Instrument (OLCI) onboard Sentinel-3A/B measurements over clean and polluted snow fields. Using OLCI spectral reflectance measurements in the range 400-1020 nm, we derived important snow properties such as spectral and broadband albedo, snow specific surface area, snow extent and grain size on a spatial grid of 300 m. The algorithm also incorporated cloud screening and atmospheric correction procedures over snow surfaces. We present validation results using ground measurements from Antarctica, the Greenland ice sheet and the French Alps. We find the spectral albedo retrieved with accuracy of better than 3% on average, making our retrievals sufficient for a variety of applications. Broadband albedo is retrieved with the average accuracy of about 5% over snow. Therefore, the uncertainties of satellite retrievals are close to experimental errors of ground measurements. The retrieved surface grain size shows good agreement with ground observations. Snow specific surface area observations are also consistent with our OLCI retrievals. We present snow albedo and grain size mapping over the inland ice sheet of Greenland for areas including dry snow, melted/melting snow and impurity rich bare ice. The algorithm can be applied to OLCI Sentinel-3 measurements providing an opportunity for creation of long-term snow property records essential for climate monitoring and data assimilation studies-especially in the Arctic region, where we face rapid environmental changes including reduction of snow/ice extent and, therefore, planetary albedo. KW - snow characteristics KW - optical remote sensing KW - snow grain size KW - specific surface area KW - albedo KW - Sentinel 3 KW - OLCI Y1 - 2019 U6 - https://doi.org/10.3390/rs11192280 SN - 2072-4292 VL - 11 IS - 19 PB - MDPI CY - Basel ER -