TY  - JOUR
A1  - v. Frankenberg, Jenny
A1  - Seidl, Rainer Ottis
A1  - Schultheiss, Corinna
A1  - Frank, Ulrike
A1  - Fuß, Sophia
A1  - Stefke, Michaela
A1  - Honekamp, Andrea
A1  - Winkler, Silke
A1  - Jäckel, Annemarie
A1  - Schindler, Wencke
A1  - Wenglarczyk, Anke
A1  - Weise, Stefanie
A1  - Heide, Judith
A1  - Stadie, Nicole
A1  - Schröder, Astrid
A1  - Baer-Henney, Dinah
A1  - van de Vijver, Ruben
A1  - Sauerland, Uli
A1  - Yatsushiro, Kazuko
A1  - Schöppe, Doreen
A1  - Blatter, Kristine
A1  - Faust, Verena
A1  - Jäger, Dana
A1  - Artelt, Cordula
A1  - Schneider, Wolfgang
A1  - Stanat, Petra
A1  - Bruchmüller, Wiebke
A1  - Sjöström, Saana
A1  - Schütz, Susann
A1  - Swietza, Romy
A1  - Zielina, Marie
A1  - Freymann, Marie
A1  - Hausmann, Nadin
A1  - Köntopp, Isabelle
A1  - Liebig, Johanna
A1  - Schnell, Annemarie
A1  - Wegener, Viktoria
A1  - Heinemann, Steffi
A1  - Haensel, Diana
A1  - Mürbe, Dirk
A1  - Pomnitz, Patricia
A1  - Siegmüller, Julia
ED  - Heide, Judith
ED  - Fritzsche, Tom
ED  - Meyer, Corinna B.
ED  - Ott, Susan
T1  - Spektrum Patholinguistik =  Schwerpunktthema: Schluck für Schluck: Dysphagietherapie bei Kindern und Erwachsenen
T1  - Spektrum Patholinguistik = Key issue: Sip by sip: Dysphagia therapy in children and adults
N2  - Das Herbsttreffen Patholinguistik wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. Die Jubiläumsveranstaltung am 19.11.2011 in Potsdam war nicht nur die 5. Auflage der Veranstaltung, sondern auch ein Fest zum 10jährigen Bestehen des Verbandes. Das Thema lautete "Schluck für Schluck: Dysphagietherapie bei Kindern und Erwachsenen". Im vorliegenden Tagungsband finden sich die Artikel der Hauptvorträge sowie die Abstracts der Posterpräsentationen.
N2  - The 'Herbsttreffen Patholinguistik' is an annual conference organized by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl) since 2007. The anniversary event on November 19th, 2011 in Potsdam marked both the 5th edition of this conference series and the 10th birthday of the vpl. The main topic of the meeting was "Sip by sip: Dysphagia therapy in children and adults". These proceedings contain the papers from the invited talks and the abstracts of the poster presentations.
T3  - Spektrum Patholinguistik - 5 
KW  - Patholinguistik
KW  - Sprachtherapie
KW  - Dysphagie
KW  - Schluckstörung
KW  - Schlucktherapie
KW  - patholinguistics
KW  - speech/language therapy
KW  - dysphagia
KW  - swallowing disorders
KW  - dysphagia therapy
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-59877
SN  - 978-3-86956-199-8
SN  - 1866-9433
SN  - 1869-3822
IS  - 5
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Döge, Nadine
A1  - Hönzke, Stefan
A1  - Schumacher, Fabian
A1  - Balzus, Benjamin
A1  - Colombo, Miriam
A1  - Hadam, Sabrina
A1  - Rancan, Fiorenza
A1  - Blume-Peytavi, Ulrike
A1  - Schäfer-Korting, Monika
A1  - Schindler, Anke
A1  - Rühl, Eckart
A1  - Skov, Per Stahl
A1  - Church, Martin K.
A1  - Hedtrich, Sarah
A1  - Kleuser, Burkhard
A1  - Bodmeier, Roland
A1  - Vogt, Annika
T1  - Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin - assessment by intradermal microdialysis and extraction from the different skin layers
JF  - Journal of controlled release
N2  - Understanding penetration not only in intact, but also in lesional skin with impaired skin barrier function is important, in order to explore the surplus value of nanoparticle-based drug delivery for anti-inflammatory dermatotherapy. Herein, short-termex vivo cultures of (i) intact human skin, (ii) skin pretreated with tape-strippings and (iii) skin pre-exposed to sodium lauryl sulfate (SLS) were used to assess the penetration of dexamethasone (Dex). Intradermal microdialysis was utilized for up to 24 h after drug application as commercial cream, nanocrystals or ethyl cellulose nanocarriers applied at the therapeutic concentration of 0.05%, respectively. In addition, Dex was assessed in culture media and extracts from stratum corneum, epidermis and dermis after 24 h, and the results were compared to those in heat-separated split skin from studies in Franz diffusion cells. Providing fast drug release, nanocrystals significantly accelerated the penetration of Dex. In contrast to the application of cream and ethyl cellulose nanocarriers, Dex was already detectable in eluates after 6 h when applying nanocrystals on intact skin. Disruption of the skin barrier further accelerated and enhanced the penetration. Encapsulation in ethyl cellulose nanocarriers delayed Dex penetration. Interestingly, for all formulations highly increased concentrations in the dialysate were observed in tape-stripped skin, whereas the extent of enhancement was less in SLS-exposed skin. The results were confirmed in tissue extracts and were in line with the predictions made by in vitro release studies and ex vivo Franz diffusion cell experiments. The use of 45 kDa probes further enabled the collection of inflammatory cytokines. However, the estimation of glucocorticoid efficacy by Interleukin (IL)-6 and IL-8 analysis was limited due to the trauma induced by the probe insertion. Ex vivo intradermal microdialysis combined with culture media analysis provides an effective, skin-sparing method for preclinical assessment of novel drug delivery systems at therapeutic doses in models of diseased skin. (C) 2016 Elsevier B.V. All rights reserved.
KW  - Drug delivery systems
KW  - Polymeric nanoparticles
KW  - Dexamethasone
KW  - Microdialysis
KW  - Skin penetration
KW  - Skin barrier disruption
Y1  - 2016
U6  - https://doi.org/10.1016/j.jconrel.2016.07.009
SN  - 0168-3659
SN  - 1873-4995
VL  - 242
SP  - 25
EP  - 34
PB  - Elsevier
CY  - Amsterdam
ER  -