TY - BOOK A1 - Schubarth, Wilfried A1 - Zylla, Birgitta A1 - Niproschke, Saskia A1 - Guder, Petra A1 - Sonnen, Bernd-Rüdeger A1 - Kahl, Wolfgang A1 - Groeger-Roth, Frederick A1 - Kaeding, Peer A1 - Böhm, Christian A1 - Voigt, Jana A1 - Sturzbecher, Dietmar A1 - Kohlstruck, Michael A1 - Möller, Kurt A1 - Rolfes, Manfred A1 - Winter, Frank A1 - Breitschwerdt, Michael A1 - Kopp, Andrea A1 - Hinze, Klaus A1 - Lösel, Friedrich A1 - Klindworth-Mohr, Antje A1 - Madl, Martina A1 - Dunand, Annelie A1 - Schanzenbächer, Stefan A1 - Rump-Räuber, Michael A1 - Roos, Alfred A1 - Seidel, Andreas A1 - Gröger, Ulli A1 - Ulbricht, Juliane A1 - Martin, Christian A1 - Behrendt, Daniel ED - Schubarth, Wilfried T1 - Nachhaltige Prävention von Kriminalität, Gewalt und Rechtsextremismus BT - Beiträge aus Wissenschaft und Praxis N2 - Was wird unter „nachhaltiger Prävention“ in der Präventionsforschung verstanden? Welche guten Beispiele für nachhaltige Prävention gibt es in der Praxis? Und v. a.: Wie lässt sich Prävention in den verschiedenen Bereichen wie Kriminalität, Gewalt und Rechtsextremismus nachhaltig gestalten? Diesen Fragen will der vorliegende Sammelband nachgehen und damit der Präventionsdebatte neue Impulse verleihen. Der Band will insbesondere die nationale sowie internationale Fachdebatte konstruktiv aufgreifen, Theorie und Praxis verbinden, „good practice“ Beispiele darstellen sowie Perspektiven nachhaltiger Prävention aufzeigen. Mit diesem Themenspektrum richtet er sich sowohl an die Wissenschaft als auch an die Praxis sowie insgesamt an eine interessierte Öffentlichkeit. N2 - What is meant by „sustainable prevention“ in prevention research? What are good examples for sustainable prevention? And above all: How can prevention in fields like crime, violence and right-wing extremism be arranged sustainably? This miscellany is focused on these questions and it is intend to give new inputs for the current discussion on sustainable prevention. Especially, the miscellany is meant to connect the national and international trade debate, to combine theory and practice, to describe examples of “good practice” as well as to show prospects of sustainable prevention. These range of topics focus on science and practice as well as an interested public in general. KW - Prävention KW - Nachhaltigkeit KW - Gewalt KW - Kriminalität KW - Rechtsextremismus KW - prevention KW - sustainability KW - violence KW - crime KW - right-wing extremism Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-70537 SN - 978-3-86956-014-4 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Ihle, Wolfgang A1 - Böhm, Andreas A1 - Esser, Günter T1 - Epidemiologie des Alkoholkonsums im Jugendalter : Ergebnisse repräsentativer Bevölkerungsstudien Y1 - 2008 ER - TY - JOUR A1 - Böhm, Andreas A1 - Flößer, Anja A1 - Ermler, Swen A1 - Fender, Anke C. A1 - Lüth, Anja A1 - Kleuser, Burkhard A1 - Schrör, Karsten A1 - Rauch, Bernhard H. T1 - Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells JF - Cardiovascular research N2 - Sphingosine-1-phosphate (S1P) is a cellular signalling lipid generated by sphingosine kinase-1 (SPHK1). The aim of the study was to investigate whether the activated coagulation factor-X (FXa) regulates SPHK1 transcription and the formation of S1P and subsequent mitogenesis and migration of human vascular smooth muscle cells (SMC). FXa induced a time- (36 h) and concentration-dependent (330 nmol/L) increase of SPHK1 mRNA and protein expression in human aortic SMC, resulting in an increased synthesis of S1P. FXa-stimulated transcription of SPHK1 was mediated by the protease-activated receptor-1 (PAR-1) and PAR-2. In human carotid artery plaques, expression of SPHK1 was observed at SMC-rich sites and was co-localized with intraplaque FX/FXa content. FXa-induced SPHK1 transcription was attenuated by inhibitors of Rho kinase (Y27632) and by protein kinase C (PKC) isoforms (GF109203X). In addition, FXa rapidly induced the activation of the small GTPase Rho A. Inhibition of signalling pathways which regulate SPHK1 expression, inhibition of its activity or siRNA-mediated SPHK1 knockdown attenuated the mitogenic and chemotactic response of human SMC to FXa. These data suggest that FXa induces SPHK1 expression and increases S1P formation independent of thrombin and that this involves the activation of Rho A and PKC signalling. In addition to its key function in coagulation, this direct effect of FXa on human SMC may increase cell proliferation and migration at sites of vessel injury and thereby contribute to the progression of vascular lesions. KW - Factor-Xa KW - Atherosclerosis KW - Proliferation KW - Smooth muscle cells KW - Sphingosine kinase-1 Y1 - 2013 U6 - https://doi.org/10.1093/cvr/cvt112 SN - 0008-6363 VL - 99 IS - 3 SP - 505 EP - 513 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Böhm, Andreas A1 - Friese, Elke A1 - Greil, Holle A1 - Lüdecke, Karin T1 - Körperliche Entwicklung und Übergewicht bei Kindern und Jugendlichen Y1 - 2002 ER - TY - CHAP A1 - Kurbel, Karl A1 - Nowak, Dawid A1 - Azodi, Amir A1 - Jaeger, David A1 - Meinel, Christoph A1 - Cheng, Feng A1 - Sapegin, Andrey A1 - Gawron, Marian A1 - Morelli, Frank A1 - Stahl, Lukas A1 - Kerl, Stefan A1 - Janz, Mariska A1 - Hadaya, Abdulmasih A1 - Ivanov, Ivaylo A1 - Wiese, Lena A1 - Neves, Mariana A1 - Schapranow, Matthieu-Patrick A1 - Fähnrich, Cindy A1 - Feinbube, Frank A1 - Eberhardt, Felix A1 - Hagen, Wieland A1 - Plauth, Max A1 - Herscheid, Lena A1 - Polze, Andreas A1 - Barkowsky, Matthias A1 - Dinger, Henriette A1 - Faber, Lukas A1 - Montenegro, Felix A1 - Czachórski, Tadeusz A1 - Nycz, Monika A1 - Nycz, Tomasz A1 - Baader, Galina A1 - Besner, Veronika A1 - Hecht, Sonja A1 - Schermann, Michael A1 - Krcmar, Helmut A1 - Wiradarma, Timur Pratama A1 - Hentschel, Christian A1 - Sack, Harald A1 - Abramowicz, Witold A1 - Sokolowska, Wioletta A1 - Hossa, Tymoteusz A1 - Opalka, Jakub A1 - Fabisz, Karol A1 - Kubaczyk, Mateusz A1 - Cmil, Milena A1 - Meng, Tianhui A1 - Dadashnia, Sharam A1 - Niesen, Tim A1 - Fettke, Peter A1 - Loos, Peter A1 - Perscheid, Cindy A1 - Schwarz, Christian A1 - Schmidt, Christopher A1 - Scholz, Matthias A1 - Bock, Nikolai A1 - Piller, Gunther A1 - Böhm, Klaus A1 - Norkus, Oliver A1 - Clark, Brian A1 - Friedrich, Björn A1 - Izadpanah, Babak A1 - Merkel, Florian A1 - Schweer, Ilias A1 - Zimak, Alexander A1 - Sauer, Jürgen A1 - Fabian, Benjamin A1 - Tilch, Georg A1 - Müller, David A1 - Plöger, Sabrina A1 - Friedrich, Christoph M. A1 - Engels, Christoph A1 - Amirkhanyan, Aragats A1 - van der Walt, Estée A1 - Eloff, J. H. P. A1 - Scheuermann, Bernd A1 - Weinknecht, Elisa ED - Meinel, Christoph ED - Polze, Andreas ED - Oswald, Gerhard ED - Strotmann, Rolf ED - Seibold, Ulrich ED - Schulzki, Bernhard T1 - HPI Future SOC Lab BT - Proceedings 2015 N2 - Das Future SOC Lab am HPI ist eine Kooperation des Hasso-Plattner-Instituts mit verschiedenen Industriepartnern. Seine Aufgabe ist die Ermöglichung und Förderung des Austausches zwischen Forschungsgemeinschaft und Industrie. Am Lab wird interessierten Wissenschaftlern eine Infrastruktur von neuester Hard- und Software kostenfrei für Forschungszwecke zur Verfügung gestellt. Dazu zählen teilweise noch nicht am Markt verfügbare Technologien, die im normalen Hochschulbereich in der Regel nicht zu finanzieren wären, bspw. Server mit bis zu 64 Cores und 2 TB Hauptspeicher. Diese Angebote richten sich insbesondere an Wissenschaftler in den Gebieten Informatik und Wirtschaftsinformatik. Einige der Schwerpunkte sind Cloud Computing, Parallelisierung und In-Memory Technologien. In diesem Technischen Bericht werden die Ergebnisse der Forschungsprojekte des Jahres 2015 vorgestellt. Ausgewählte Projekte stellten ihre Ergebnisse am 15. April 2015 und 4. November 2015 im Rahmen der Future SOC Lab Tag Veranstaltungen vor. KW - Future SOC Lab KW - Forschungsprojekte KW - Multicore Architekturen KW - In-Memory Technologie KW - Cloud Computing KW - maschinelles Lernen KW - künstliche Intelligenz Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-102516 ER - TY - JOUR A1 - Schilling, Theodor A1 - Goeke, Henning A1 - Böhm, Otto A1 - Brunner, Manuel A1 - Davarnejad, Leyla A1 - Gerbig, Stephan A1 - Wagner, Marlene A1 - Zimmermann, Andreas T1 - MenschenRechtsMagazin : Informationen | Meinungen | Analysen N2 - Aus dem Inhalt: – Replik auf Felix Brönners Beitrag im MRM – MenschenRechtsMagazin Heft 1/2 2019 „Koloniale Kontinuitäten im Menschenrechtsdiskurs“ S. 24 – 37 (Teil 1) – Der Nachweis von Verletzungen der Menschenrechte durch Satellitenbilder – Dargestellt am Beispiel der Praxis von Untersuchungskommissionen des Menschenrechtsrates der Vereinten Nationen – Kinder als Menschenrechtsverteidiger:innen – Anforderungen an ein förderliches Umfeld für das Engagement von Kinder T3 - MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen - 26.2021/1 Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-496720 SN - 1434-2820 VL - 26 IS - 1 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Böhm, Stanislav A1 - Tomaszciková, Jana A1 - Imrich, Ján A1 - Danihel, Ivan A1 - Kristian, Pavol A1 - Koch, Andreas A1 - Kleinpeter, Erich A1 - Klika, Karel D. T1 - Computational study to assign structure, tautomerism, E/Z and s-cis/s-trans isomerism, pi-delocalization, partial aromaticity, and the ring size of 1,3-thiazolidin-4-ones and 1,3-thiazin-4-ones formed from thiosemicarbazides N2 - A set of structures encompassing 1-(9-acridinyl)thiosemicarbazide and its 2-methyl derivative together with their various tautomeric structures; the 5-membered ring 1,3-thiazolidin-4-one products resulting from the reaction of 1- (9-acridinyl)thiosemicarbazide and its 2-methyl derivative with dimethyl acetylenedicarboxylate (DMAD) together with the alternative 6-membered ring isomeric reaction products as well as other potential isomeric structures; and the 6- membered ring 1,3-thiazin-4-one product resulting from the reaction of 2-methyl-1-(9-acridinyl)thiosemicarbazide with methyl propiolate (MP) together with the alternative 5-membered ring isomeric reaction product were all extensively studied by molecular modeling calculations using DFT at the B3LYP/6-31G(d,p) level of theory. The ring-chain tautomerism of the thiosemicarbazides, the regio- and stereoselectivity of the reactions, the adopted conformations and E/Z configurations of the products, the prototropic tautomerism of all the compounds, and the reasons for the predominance of the s-cis conformation of the Z configuration of the 1,3-thiazolidin-4-one product in particular were all extensively analyzed. Comparison of the modeled structures were also made to the 1,3-thiazolidin-4-one and 1,3-thiazin-4-one structures of the methyl derivative as well as 1-(9-acridinyl)thiosemicarbazide available from X-ray crystallographic analysis. Tactics utilizing spectroscopic methods {IR frequencies (;) and NMR chemical shifts (;), scalar coupling constants (J), and NOEs (;)} in conjunction with molecular modeling calculations of the spectral parameters {frequency calculations (;) and NMR ; using the GIAO method and J by calculation of the Fermi contact term} were evaluated in terms of proving 5- or 6-membered ring formation. Y1 - 2009 SN - 0166-1280 ER - TY - JOUR A1 - Allan, Eric A1 - Bossdorf, Oliver A1 - Dormann, Carsten F. A1 - Prati, Daniel A1 - Gossner, Martin M. A1 - Tscharntke, Teja A1 - Blüthgen, Nico A1 - Bellach, Michaela A1 - Birkhofer, Klaus A1 - Boch, Steffen A1 - Böhm, Stefan A1 - Börschig, Carmen A1 - Chatzinotas, Antonis A1 - Christ, Sabina A1 - Daniel, Rolf A1 - Diekötter, Tim A1 - Fischer, Christiane A1 - Friedl, Thomas A1 - Glaser, Karin A1 - Hallmann, Christine A1 - Hodac, Ladislav A1 - Hölzel, Norbert A1 - Jung, Kirsten A1 - Klein, Alexandra-Maria A1 - Klaus, Valentin H. A1 - Kleinebecker, Till A1 - Krauss, Jochen A1 - Lange, Markus A1 - Morris, E. Kathryn A1 - Müller, Jörg A1 - Nacke, Heiko A1 - Pasalic, Esther A1 - Rillig, Matthias C. A1 - Rothenwoehrer, Christoph A1 - Schally, Peter A1 - Scherber, Christoph A1 - Schulze, Waltraud X. A1 - Socher, Stephanie A. A1 - Steckel, Juliane A1 - Steffan-Dewenter, Ingolf A1 - Türke, Manfred A1 - Weiner, Christiane N. A1 - Werner, Michael A1 - Westphal, Catrin A1 - Wolters, Volkmar A1 - Wubet, Tesfaye A1 - Gockel, Sonja A1 - Gorke, Martin A1 - Hemp, Andreas A1 - Renner, Swen C. A1 - Schöning, Ingo A1 - Pfeiffer, Simone A1 - König-Ries, Birgitta A1 - Buscot, Francois A1 - Linsenmair, Karl Eduard A1 - Schulze, Ernst-Detlef A1 - Weisser, Wolfgang W. A1 - Fischer, Markus T1 - Interannual variation in land-use intensity enhances grassland multidiversity JF - Proceedings of the National Academy of Sciences of the United States of America N2 - Although temporal heterogeneity is a well-accepted driver of biodiversity, effects of interannual variation in land-use intensity (LUI) have not been addressed yet. Additionally, responses to land use can differ greatly among different organisms; therefore, overall effects of land-use on total local biodiversity are hardly known. To test for effects of LUI (quantified as the combined intensity of fertilization, grazing, and mowing) and interannual variation in LUI (SD in LUI across time), we introduce a unique measure of whole-ecosystem biodiversity, multidiversity. This synthesizes individual diversity measures across up to 49 taxonomic groups of plants, animals, fungi, and bacteria from 150 grasslands. Multidiversity declined with increasing LUI among grasslands, particularly for rarer species and aboveground organisms, whereas common species and belowground groups were less sensitive. However, a high level of interannual variation in LUI increased overall multidiversity at low LUI and was even more beneficial for rarer species because it slowed the rate at which the multidiversity of rare species declined with increasing LUI. In more intensively managed grasslands, the diversity of rarer species was, on average, 18% of the maximum diversity across all grasslands when LUI was static over time but increased to 31% of the maximum when LUI changed maximally over time. In addition to decreasing overall LUI, we suggest varying LUI across years as a complementary strategy to promote biodiversity conservation. KW - biodiversity loss KW - agricultural grasslands KW - Biodiversity Exploratories Y1 - 2014 U6 - https://doi.org/10.1073/pnas.1312213111 SN - 0027-8424 VL - 111 IS - 1 SP - 308 EP - 313 PB - National Acad. of Sciences CY - Washington ER - TY - JOUR A1 - Manning, Pete A1 - Gossner, Martin M. A1 - Bossdorf, Oliver A1 - Allan, Eric A1 - Zhang, Yuan-Ye A1 - Prati, Daniel A1 - Blüthgen, Nico A1 - Boch, Steffen A1 - Böhm, Stefan A1 - Börschig, Carmen A1 - Hölzel, Norbert A1 - Jung, Kirsten A1 - Klaus, Valentin H. A1 - Klein, Alexandra-Maria A1 - Kleinebecker, Till A1 - Krauss, Jochen A1 - Lange, Markus A1 - Müller, Jörg A1 - Pasalic, Esther A1 - Socher, Stephanie A. A1 - Tschapka, Marco A1 - Türke, Manfred A1 - Weiner, Christiane A1 - Werner, Michael A1 - Gockel, Sonja A1 - Hemp, Andreas A1 - Renner, Swen C. A1 - Wells, Konstans A1 - Buscot, Francois A1 - Kalko, Elisabeth K. V. A1 - Linsenmair, Karl Eduard A1 - Weisser, Wolfgang W. A1 - Fischer, Markus T1 - Grassland management intensification weakens the associations among the diversities of multiple plant and animal taxa JF - Ecology : a publication of the Ecological Society of America N2 - Land-use intensification is a key driver of biodiversity change. However, little is known about how it alters relationships between the diversities of different taxonomic groups, which are often correlated due to shared environmental drivers and trophic interactions. Using data from 150 grassland sites, we examined how land-use intensification (increased fertilization, higher livestock densities, and increased mowing frequency) altered correlations between the species richness of 15 plant, invertebrate, and vertebrate taxa. We found that 54% of pairwise correlations between taxonomic groups were significant and positive among all grasslands, while only one was negative. Higher land-use intensity substantially weakened these correlations(35% decrease in rand 43% fewer significant pairwise correlations at high intensity), a pattern which may emerge as a result of biodiversity declines and the breakdown of specialized relationships in these conditions. Nevertheless, some groups (Coleoptera, Heteroptera, Hymenoptera and Orthoptera) were consistently correlated with multidiversity, an aggregate measure of total biodiversity comprised of the standardized diversities of multiple taxa, at both high and lowland-use intensity. The form of intensification was also important; increased fertilization and mowing frequency typically weakened plant-plant and plant-primary consumer correlations, whereas grazing intensification did not. This may reflect decreased habitat heterogeneity under mowing and fertilization and increased habitat heterogeneity under grazing. While these results urge caution in using certain taxonomic groups to monitor impacts of agricultural management on biodiversity, they also suggest that the diversities of some groups are reasonably robust indicators of total biodiversity across a range of conditions. KW - Biodiversity indicators KW - correlation KW - fertilization KW - grassland management KW - grazing KW - land-use change KW - land-use intensity KW - mowing KW - multidiversity KW - multitrophic interactions Y1 - 2015 U6 - https://doi.org/10.1890/14-1307.1 SN - 0012-9658 SN - 1939-9170 VL - 96 IS - 6 SP - 1492 EP - 1501 PB - Wiley CY - Washington ER - TY - JOUR A1 - Klinka, Karel D. A1 - Imrich, Jan A1 - Danihel, I. A1 - Bohm, Stanislav A1 - Kristian, Pavol A1 - Harnul'akova, S. A1 - Pihlaja, Kalevi A1 - Koch, Andreas A1 - Kleinpeter, Erich T1 - Configuration and E/Z interconversion mechanism of O(S)-allyl-S(O)-methyl-N-(acridin-9-yl)iminothiocarbonate N2 - The configuration and dynamic behavior of O-allyl-S-methyl-N-(acridin-9-yl)iminothiocarbonate (1) and its S- allyl-O-methyl regioisomer (2) were studied using quantum chemical calculations and by applying a novel graphical method to scatter maps obtained from MD simulations for evaluation of an NOE-weighted internuclear distance (r(NOE)). Energy calculations indicated that the Z configuration was predominant for each compound and, further, this was supported both by the calculated chemical shifts and the rNOE. Both N-inversion- and rotation-type transition-state structures were also calculated for the E/Z isomerization process, the results indicating that the preferred interconversion mechanism for 1 is N-inversion, but contrastingly, interconversion via rotation is equally as probable as N-inversion for 2. This supports the notion that one or the other or both pathways can be active and each system needs to be assessed on a case- by-case basis. Copyright (c) 2005 John Wiley & Sons, Ltd Y1 - 2005 SN - 0749-1581 ER -