TY - JOUR A1 - Labudek, Sarah A1 - Schweizer, Geoffrey A1 - Roth, Anika A1 - Pizzera, Alexandra A1 - Plessner, Henning A1 - Brand, Ralf T1 - REFS-D BT - Eine deutschsprachige Skala zur Erfassung der Schiedsrichterselbstwirksamkeit BT - A German Scale for Assessing Referee Self-Efficacy JF - Zeitschrift für Sportpsychologie N2 - Ziel des vorliegenden Artikels ist die teststatistische Überprüfung und Validierung einer deutschsprachigen Version der Referee Self-Efficacy Scale (REFS). Die REFS erfasst im englischsprachigen Original die Selbstwirksamkeit von Schiedsrichterinnen und Schiedsrichtern mit den Subskalen Wissen über das Spiel, Entscheidungsfindung, Druck und Kommunikation. Die Items wurden mit Hilfe der Übersetzung-Rückübersetzung ins Deutsche übertragen. Die Struktur und die psychometrischen Eigenschaften der deutschen Items wurden anhand einer Stichprobe aus 265 deutschsprachigen Fußballschiedsrichterinnen und -schiedsrichtern überprüft. Da die im englischsprachigen Original vorgeschlagene Skalenzuordnung der REFS nach der Übersetzung ins Deutsche nicht replizierbar war, wurden Items mit mangelhaften Skaleneigenschaften aus der deutschsprachigen REFS-Version (REFS-D) ausgeschlossen. Das Resultat der Analysen ist eine Skala mit acht Items, die sich drei Subskalen, Spielumsetzung, Druck und Kommunikation, zuordnen lassen. Die REFS-D weist zufriedenstellende interne Konsistenzen und signifikante mittelhohe Korrelationen mit allgemeiner Selbstwirksamkeit auf. Trotz einiger Einschränkungen stellt die REFS-D als ökonomische Skala einen Ansatzpunkt für zukünftige Forschung dar. N2 - The purpose of the present article was to evaluate statistically and validate a German version of the Referee Self-Efficacy Scale (REFS). The English REFS assesses referee self-efficacy and consists of the scales Game Knowledge, Decision-Making, Pressure, and Communication. Data from 265 soccer referees was used to evaluate the structure and psychometric properties of the German items. Since we could not replicate the original dimension structure, we excluded items from the German REFS (REFS-D) that showed poor item characteristics. Analyses resulted in a short REFS-D consisting of eight items, subdivided into three dimensions: game realization, pressure, and communication. Results show acceptable internal consistencies. All three subscales of the REFS-D showed significant moderate correlations with general self-efficacy. Despite some limitations, the REFS-D represents an economic questionnaire and starting point for future research. T2 - REFS-D KW - Refficacy KW - Schiedsrichterentscheidungen KW - Selbstwirksamkeit KW - Faktorenanalyse KW - Referees' Decisions KW - Self-efficacy KW - Factor+Analysis Y1 - 2019 U6 - https://doi.org/10.1026/1612-5010/a000256 SN - 1612-5010 SN - 2190-6300 VL - 26 IS - 1 SP - 15 EP - 24 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Tepel, Martin A1 - Armbruster, Franz Paul A1 - Groen, Hans Juergen A1 - Scholze, Alexandra A1 - Reichetzeder, Christoph A1 - Roth, Heinz Jürgen A1 - Hocher, Berthold T1 - Nonoxidized, biologically active parathyroid hormone determines mortality in hemodialysis patients JF - The journal of clinical endocrinology & metabolism N2 - Background: It was shown that nonoxidized PTH (n-oxPTH) is bioactive, whereas the oxidation of PTH results in a loss of biological activity. Methods: In this study we analyzed the association of n-oxPTH on mortality in hemodialysis patients using a recently developed assay system. Results: Hemodialysis patients (224 men, 116 women) had a median age of 66 years. One hundred seventy patients (50%) died during the follow-up period of 5 years. Median n-oxPTH levels were higher in survivors (7.2 ng/L) compared with deceased patients (5.0 ng/L; P = .002). Survival analysis showed an increased survival in the highest n-oxPTH tertile compared with the lowest n-oxPTH tertile (chi(2), 14.3; P = 0008). Median survival was 1702 days in the highest n-oxPTH tertile, whereas it was only 453 days in the lowest n-oxPTH tertile. Multivariable-adjusted Cox regression showed that higher age increased odds for death, whereas higher n-oxPTH reduced the odds for death. Another model analyzing a subgroup of patients with intact PTH (iPTH) concentrations at baseline above the upper normal range of the iPTH assay (70 ng/L) revealed that mortality in this subgroup was associated with oxidized PTH but not with n-oxPTH levels. Conclusions: The predictive power of n-oxPTH and iPTH on the mortality of hemodialysis patients differs substantially. Measurements of n-oxPTH may reflect the hormone status more precisely. The iPTH-associated mortality is most likely describing oxidative stress-related mortality. Y1 - 2013 U6 - https://doi.org/10.1210/jc.2013-2139 SN - 0021-972X SN - 1945-7197 VL - 98 IS - 12 SP - 4744 EP - 4751 PB - Endocrine Society CY - Chevy Chase ER - TY - CHAP A1 - Hocher, Berthold A1 - Armbruster, Franz Paul A1 - Scholze, Alexandra A1 - Marckmann, Peter A1 - Reichetzeder, Christoph A1 - Roth, Heinz Jürgen A1 - Tepel, Martin T1 - Non-oxidized, biological active parathyroid hormone determines motality in hemodialsysis patients T2 - Nephrology, dialysis, transplantation Y1 - 2013 SN - 0931-0509 VL - 28 SP - 33 EP - 33 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Hoff, Ulrike A1 - Biskaborn, Boris A1 - Dirksen, Veronika G. A1 - Dirksen, Oleg A1 - Kuhn, Gerhard A1 - Meyer, Hanno A1 - Nazarova, Larisa B. A1 - Roth, Alexandra A1 - Diekmann, Bernhard T1 - Holocene environment of Central Kamchatka, Russia: Implications from a multi-proxy record of Two-Yurts Lake JF - Global and planetary change N2 - Within the scope of Russian German palaeoenvironmental research, Two-Yurts Lake (TYL, Dvuh-Yurtochnoe in Russian) was chosen as the main scientific target area to decipher Holocene climate variability on Kamchatka. The 5 x 2 km large and 26 m deep lake is of proglacial origin and situated on the eastern flank of Sredinny Ridge at the northwestern end of the Central Kamchatka Valley, outside the direct influence of active volcanism. Here, we present results of a multi-proxy study on sediment cores, spanning about the last 7000 years. The general tenor of the TYL record is an increase in continentality and winter snow cover in conjunction with a decrease in temperature, humidity, and biological productivity after 5000-4500 cal yrs BP, inferred from pollen and diatom data and the isotopic composition of organic carbon. The TYL proxy data also show that the late Holocene was punctuated by two colder spells, roughly between 4500 and 3500 cal yrs BP and between 1000 and 200 cal yrs BP, as local expressions of the Neoglacial and Little Ice Age, respectively. These environmental changes can be regarded as direct and indirect responses to climate change, as also demonstrated by other records in the regional terrestrial and marine realm. Long-term climate deterioration was driven by decreasing insolation, while the short-term climate excursions are best explained by local climatic processes. The latter affect the configuration of atmospheric pressure systems that control the sources as well as the temperature and moisture of air masses reaching Kamchatka. (C) 2015 Elsevier B.V. All rights reserved. KW - Kamchatka KW - North Pacific KW - Holocene Climate KW - Palaeolimnology KW - Diatoms KW - Pollen Y1 - 2015 U6 - https://doi.org/10.1016/j.gloplacha.2015.07.011 SN - 0921-8181 SN - 1872-6364 VL - 134 SP - 101 EP - 117 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Scholze, Alexandra A1 - Liu, Ying A1 - Pedersen, Lise A1 - Xia, Shengqiang A1 - Roth, Heinz J. A1 - Hocher, Berthold A1 - Rasmussen, Lars Melholt A1 - Tepel, Martin T1 - Soluble alpha-Klotho and its relation to kidney function and fibroblast growth factor-23 JF - The journal of clinical endocrinology & metabolism N2 - Context: Relations between fibroblast growth factor-23 (FGF-23), soluble alpha-klotho (s-alpha-klotho), and kidney function in chronic kidney disease (CKD) are still unclear. Especially the role of s-alpha-klotho requires further study. Objectives: Our objectives were to analyze the relation of s-alpha-klotho to estimated glomerular filtration rate (eGFR), FGF-23, and other parameters of calcium-phosphate metabolism and to investigate the response of s-alpha-klotho to cholecalciferol. Patients, Design, and Setting: Twenty-four CKD (stage 1-5) patients participated in this 8-week randomized controlled trial (vitamin D and chronic renal insufficiency). Interventions: Interventions included 40 000 IU cholecalciferol or placebo weekly. Main Outcome Measure: S-alpha-klotho was determined by ELISA with antihuman klotho antibodies 67G3 and 91F1. Results: For all patients, s-alpha-klotho concentrations did not differ between CKD stages. When patients were subdivided based on FGF-23 concentrations, a positive association of s-alpha-klotho with eGFR became apparent in patients with lower than median FGF-23 concentrations but not in those above median value. Patients with s-alpha-klotho below 204 pg/mL showed higher age, lower phosphate clearance, and lower bone-specific alkaline phosphatase compared with patients with higher s-alpha-klotho. Treatment with cholecalciferol significantly increased 1,25-dihydroxyvitamin D. The increase of FGF-23 had only borderline significance. There was no significant effect of high-dose cholecalciferol administration for 8 weeks on plasma s-alpha-klotho. Conclusions: CKD patients with s-alpha-klotho below 204 pg/mL had higher age, lower phosphate clearance, and lower bone-specific alkaline phosphatase. An association of s-alpha-klotho with eGFR was observed only in the presence of close to normal, but not high, FGF-23 concentrations. Cholecalciferol treatment did not change s-alpha-klotho concentrations. Y1 - 2014 U6 - https://doi.org/10.1210/jc.2013-4171 SN - 0021-972X SN - 1945-7197 VL - 99 IS - 5 SP - E855 EP - E861 PB - Endocrine Society CY - Washington ER -