TY - RPRT A1 - Brodeur, Abel A1 - Mikola, Derek A1 - Cook, Nikolai A1 - Brailey, Thomas A1 - Briggs, Ryan A1 - Gendre, Alexandra de A1 - Dupraz, Yannick A1 - Fiala, Lenka A1 - Gabani, Jacopo A1 - Gauriot, Romain A1 - Haddad, Joanne A1 - Lima, Goncalo A1 - Ankel-Peters, Jörg A1 - Dreber, Anna A1 - Campbell, Douglas A1 - Kattan, Lamis A1 - Fages, Diego Marino A1 - Mierisch, Fabian A1 - Sun, Pu A1 - Wright, Taylor A1 - Connolly, Marie A1 - Hoces de la Guardia, Fernando A1 - Johannesson, Magnus A1 - Miguel, Edward A1 - Vilhuber, Lars A1 - Abarca, Alejandro A1 - Acharya, Mahesh A1 - Adjisse, Sossou Simplice A1 - Akhtar, Ahwaz A1 - Lizardi, Eduardo Alberto Ramirez A1 - Albrecht, Sabina A1 - Andersen, Synve Nygaard A1 - Andlib, Zubaria A1 - Arrora, Falak A1 - Ash, Thomas A1 - Bacher, Etienne A1 - Bachler, Sebastian A1 - Bacon, Félix A1 - Bagues, Manuel A1 - Balogh, Timea A1 - Batmanov, Alisher A1 - Barschkett, Mara A1 - Basdil, B. Kaan A1 - Dower, Jaromneda A1 - Castek, Ondrej A1 - Caviglia-Harris, Jill A1 - Strand, Gabriella Chauca A1 - Chen, Shi A1 - Chzhen, Asya A1 - Chung, Jong A1 - Collins, Jason A1 - Coppock, Alexander A1 - Cordeau, Hugo A1 - Couillard, Ben A1 - Crechet, Jonathan A1 - Crippa, Lorenzo A1 - Cui, Jeanne A1 - Czymara, Christian A1 - Daarstad, Haley A1 - Dao, Danh Chi A1 - Dao, Dong A1 - Schmandt, Marco David A1 - Linde, Astrid de A1 - Melo, Lucas De A1 - Deer, Lachlan A1 - Vera, Micole De A1 - Dimitrova, Velichka A1 - Dollbaum, Jan Fabian A1 - Dollbaum, Jan Matti A1 - Donnelly, Michael A1 - Huynh, Luu Duc Toan A1 - Dumbalska, Tsvetomira A1 - Duncan, Jamie A1 - Duong, Kiet Tuan A1 - Duprey, Thibaut A1 - Dworschak, Christoph A1 - Ellingsrud, Sigmund A1 - Elminejad, Ali A1 - Eissa, Yasmine A1 - Erhart, Andrea A1 - Etingin-Frati, Giulian A1 - Fatemi-Pour, Elaheh A1 - Federice, Alexa A1 - Feld, Jan A1 - Fenig, Guidon A1 - Firouzjaeiangalougah, Mojtaba A1 - Fleisje, Erlend A1 - Fortier-Chouinard, Alexandre A1 - Engel, Julia Francesca A1 - Fries, Tilman A1 - Fortier, Reid A1 - Fréchet, Nadjim A1 - Galipeau, Thomas A1 - Gallegos, Sebastián A1 - Gangji, Areez A1 - Gao, Xiaoying A1 - Garnache, Cloé A1 - Gáspár, Attila A1 - Gavrilova, Evelina A1 - Ghosh, Arijit A1 - Gibney, Garreth A1 - Gibson, Grant A1 - Godager, Geir A1 - Goff, Leonard A1 - Gong, Da A1 - González, Javier A1 - Gretton, Jeremy A1 - Griffa, Cristina A1 - Grigoryeva, Idaliya A1 - Grtting, Maja A1 - Guntermann, Eric A1 - Guo, Jiaqi A1 - Gugushvili, Alexi A1 - Habibnia, Hooman A1 - Häffner, Sonja A1 - Hall, Jonathan D. A1 - Hammar, Olle A1 - Kordt, Amund Hanson A1 - Hashimoto, Barry A1 - Hartley, Jonathan S. A1 - Hausladen, Carina I. A1 - Havránek, Tomáš A1 - Hazen, Jacob A1 - He, Harry A1 - Hepplewhite, Matthew A1 - Herrera-Rodriguez, Mario A1 - Heuer, Felix A1 - Heyes, Anthony A1 - Ho, Anson T. Y. A1 - Holmes, Jonathan A1 - Holzknecht, Armando A1 - Hsu, Yu-Hsiang Dexter A1 - Hu, Shiang-Hung A1 - Huang, Yu-Shiuan A1 - Huebener, Mathias A1 - Huber, Christoph A1 - Huynh, Kim P. A1 - Irsova, Zuzana A1 - Isler, Ozan A1 - Jakobsson, Niklas A1 - Frith, Michael James A1 - Jananji, Raphaël A1 - Jayalath, Tharaka A. A1 - Jetter, Michael A1 - John, Jenny A1 - Forshaw, Rachel Joy A1 - Juan, Felipe A1 - Kadriu, Valon A1 - Karim, Sunny A1 - Kelly, Edmund A1 - Dang, Duy Khanh Hoang A1 - Khushboo, Tazia A1 - Kim, Jin A1 - Kjellsson, Gustav A1 - Kjelsrud, Anders A1 - Kotsadam, Andreas A1 - Korpershoek, Jori A1 - Krashinsky, Lewis A1 - Kundu, Suranjana A1 - Kustov, Alexander A1 - Lalayev, Nurlan A1 - Langlois, Audrée A1 - Laufer, Jill A1 - Lee-Whiting, Blake A1 - Leibing, Andreas A1 - Lenz, Gabriel A1 - Levin, Joel A1 - Li, Peng A1 - Li, Tongzhe A1 - Lin, Yuchen A1 - Listo, Ariel A1 - Liu, Dan A1 - Lu, Xuewen A1 - Lukmanova, Elvina A1 - Luscombe, Alex A1 - Lusher, Lester R. A1 - Lyu, Ke A1 - Ma, Hai A1 - Mäder, Nicolas A1 - Makate, Clifton A1 - Malmberg, Alice A1 - Maitra, Adit A1 - Mandas, Marco A1 - Marcus, Jan A1 - Margaryan, Shushanik A1 - Márk, Lili A1 - Martignano, Andres A1 - Marsh, Abigail A1 - Masetto, Isabella A1 - McCanny, Anthony A1 - McManus, Emma A1 - McWay, Ryan A1 - Metson, Lennard A1 - Kinge, Jonas Minet A1 - Mishra, Sumit A1 - Mohnen, Myra A1 - Möller, Jakob A1 - Montambeault, Rosalie A1 - Montpetit, Sébastien A1 - Morin, Louis-Philippe A1 - Morris, Todd A1 - Moser, Scott A1 - Motoki, Fabio A1 - Muehlenbachs, Lucija A1 - Musulan, Andreea A1 - Musumeci, Marco A1 - Nabin, Munirul A1 - Nchare, Karim A1 - Neubauer, Florian A1 - Nguyen, Quan M. P. A1 - Nguyen, Tuan A1 - Nguyen-Tien, Viet A1 - Niazi, Ali A1 - Nikolaishvili, Giorgi A1 - Nordstrom, Ardyn A1 - Nü, Patrick A1 - Odermatt, Angela A1 - Olson, Matt A1 - ien, Henning A1 - Ölkers, Tim A1 - Vert, Miquel Oliver i. A1 - Oral, Emre A1 - Oswald, Christian A1 - Ousman, Ali A1 - Özak, Ömer A1 - Pandey, Shubham A1 - Pavlov, Alexandre A1 - Pelli, Martino A1 - Penheiro, Romeo A1 - Park, RyuGyung A1 - Martel, Eva Pérez A1 - Petrovičová, Tereza A1 - Phan, Linh A1 - Prettyman, Alexa A1 - Procházka, Jakub A1 - Putri, Aqila A1 - Quandt, Julian A1 - Qiu, Kangyu A1 - Nguyen, Loan Quynh Thi A1 - Rahman, Andaleeb A1 - Rea, Carson H. A1 - Reiremo, Adam A1 - Renée, Laëtitia A1 - Richardson, Joseph A1 - Rivers, Nicholas A1 - Rodrigues, Bruno A1 - Roelofs, William A1 - Roemer, Tobias A1 - Rogeberg, Ole A1 - Rose, Julian A1 - Roskos-Ewoldsen, Andrew A1 - Rosmer, Paul A1 - Sabada, Barbara A1 - Saberian, Soodeh A1 - Salamanca, Nicolas A1 - Sator, Georg A1 - Sawyer, Antoine A1 - Scates, Daniel A1 - Schlüter, Elmar A1 - Sells, Cameron A1 - Sen, Sharmi A1 - Sethi, Ritika A1 - Shcherbiak, Anna A1 - Sogaolu, Moyosore A1 - Soosalu, Matt A1 - Srensen, Erik A1 - Sovani, Manali A1 - Spencer, Noah A1 - Staubli, Stefan A1 - Stans, Renske A1 - Stewart, Anya A1 - Stips, Felix A1 - Stockley, Kieran A1 - Strobel, Stephenson A1 - Struby, Ethan A1 - Tang, John A1 - Tanrisever, Idil A1 - Yang, Thomas Tao A1 - Tastan, Ipek A1 - Tatić, Dejan A1 - Tatlow, Benjamin A1 - Seuyong, Féraud Tchuisseu A1 - Thériault, Rémi A1 - Thivierge, Vincent A1 - Tian, Wenjie A1 - Toma, Filip-Mihai A1 - Totarelli, Maddalena A1 - Tran, Van-Anh A1 - Truong, Hung A1 - Tsoy, Nikita A1 - Tuzcuoglu, Kerem A1 - Ubfal, Diego A1 - Villalobos, Laura A1 - Walterskirchen, Julian A1 - Wang, Joseph Taoyi A1 - Wattal, Vasudha A1 - Webb, Matthew D. A1 - Weber, Bryan A1 - Weisser, Reinhard A1 - Weng, Wei-Chien A1 - Westheide, Christian A1 - White, Kimberly A1 - Winter, Jacob A1 - Wochner, Timo A1 - Woerman, Matt A1 - Wong, Jared A1 - Woodard, Ritchie A1 - Wroński, Marcin A1 - Yazbeck, Myra A1 - Yang, Gustav Chung A1 - Yap, Luther A1 - Yassin, Kareman A1 - Ye, Hao A1 - Yoon, Jin Young A1 - Yurris, Chris A1 - Zahra, Tahreen A1 - Zaneva, Mirela A1 - Zayat, Aline A1 - Zhang, Jonathan A1 - Zhao, Ziwei A1 - Yaolang, Zhong T1 - Mass reproducibility and replicability BT - a new hope T2 - I4R discussion paper series N2 - This study pushes our understanding of research reliability by reproducing and replicating claims from 110 papers in leading economic and political science journals. The analysis involves computational reproducibility checks and robustness assessments. It reveals several patterns. First, we uncover a high rate of fully computationally reproducible results (over 85%). Second, excluding minor issues like missing packages or broken pathways, we uncover coding errors for about 25% of studies, with some studies containing multiple errors. Third, we test the robustness of the results to 5,511 re-analyses. We find a robustness reproducibility of about 70%. Robustness reproducibility rates are relatively higher for re-analyses that introduce new data and lower for re-analyses that change the sample or the definition of the dependent variable. Fourth, 52% of re-analysis effect size estimates are smaller than the original published estimates and the average statistical significance of a re-analysis is 77% of the original. Lastly, we rely on six teams of researchers working independently to answer eight additional research questions on the determinants of robustness reproducibility. Most teams find a negative relationship between replicators' experience and reproducibility, while finding no relationship between reproducibility and the provision of intermediate or even raw data combined with the necessary cleaning codes. KW - conomics KW - open science KW - political science KW - replication KW - reproduction KW - research transparency Y1 - 2024 SN - 2752-1931 IS - 107 PB - Institute for Replication CY - Essen ER - TY - JOUR A1 - Schichor, Christian A1 - Albrecht, Valerie A1 - Korte, Benjamin A1 - Buchner, Alexander A1 - Riesenberg, Rainer A1 - Mysliwietz, Josef A1 - Paron, Igor A1 - Motaln, Helena A1 - Turnsek, Tamara Lah A1 - Juerchott, Kathrin A1 - Selbig, Joachim A1 - Tonn, Jörg-Christian T1 - Mesenchymal stem cells and glioma cells form a structural as well as a functional syncytium in vitro JF - Experimental neurology N2 - The interaction of human mesenchymal stem cells (hMSCs) and tumor cells has been investigated in various contexts. HMSCs are considered as cellular treatment vectors based on their capacity to migrate towards a malignant lesion. However, concerns about unpredictable behavior of transplanted hMSCs are accumulating. In malignant gliomas, the recruitment mechanism is driven by glioma-secreted factors which lead to accumulation of both, tissue specific stem cells as well as bone marrow derived hMSCs within the tumor. The aim of the present work was to study specific cellular interactions between hMSCs and glioma cells in vitro. We show, that glioma cells as well as hMSCs differentially express connexins. and that they interact via gap-junctional coupling. Besides this so-called functional syncytium formation, we also provide evidence of cell fusion events (structural syncytium). These complex cellular interactions led to an enhanced migration and altered proliferation of both, tumor and mesenchymal stem cell types in vitro. The presented work shows that glioma cells display signs of functional as well as structural syncytium formation with hMSCs in vitro. The described cellular phenomena provide new insight into the complexity of interaction patterns between tumor cells and host cells. Based on these findings, further studies are warranted to define the impact of a functional or structural syncytium formation on malignant tumors and cell based therapies in vivo. KW - Mesenchymal stem cell KW - Glioma KW - Syncytium KW - Gap junction KW - Fusion Y1 - 2012 U6 - https://doi.org/10.1016/j.expneurol.2011.12.033 SN - 0014-4886 VL - 234 IS - 1 SP - 208 EP - 219 PB - Elsevier CY - San Diego ER - TY - BOOK A1 - Albrecht, Alexander A1 - Naumann, Felix T1 - Understanding cryptic schemata in large extract-transform-load systems N2 - Extract-Transform-Load (ETL) tools are used for the creation, maintenance, and evolution of data warehouses, data marts, and operational data stores. ETL workflows populate those systems with data from various data sources by specifying and executing a DAG of transformations. Over time, hundreds of individual workflows evolve as new sources and new requirements are integrated into the system. The maintenance and evolution of large-scale ETL systems requires much time and manual effort. A key problem is to understand the meaning of unfamiliar attribute labels in source and target databases and ETL transformations. Hard-to-understand attribute labels lead to frustration and time spent to develop and understand ETL workflows. We present a schema decryption technique to support ETL developers in understanding cryptic schemata of sources, targets, and ETL transformations. For a given ETL system, our recommender-like approach leverages the large number of mapped attribute labels in existing ETL workflows to produce good and meaningful decryptions. In this way we are able to decrypt attribute labels consisting of a number of unfamiliar few-letter abbreviations, such as UNP_PEN_INT, which we can decrypt to UNPAID_PENALTY_INTEREST. We evaluate our schema decryption approach on three real-world repositories of ETL workflows and show that our approach is able to suggest high-quality decryptions for cryptic attribute labels in a given schema. N2 - Extract-Transform-Load (ETL) Tools werden häufig beim Erstellen, der Wartung und der Weiterentwicklung von Data Warehouses, Data Marts und operationalen Datenbanken verwendet. ETL Workflows befüllen diese Systeme mit Daten aus vielen unterschiedlichen Quellsystemen. Ein ETL Workflow besteht aus mehreren Transformationsschritten, die einen DAG-strukturierter Graphen bilden. Mit der Zeit entstehen hunderte individueller ETL Workflows, da neue Datenquellen integriert oder neue Anforderungen umgesetzt werden müssen. Die Wartung und Weiterentwicklung von großen ETL Systemen benötigt viel Zeit und manuelle Arbeit. Ein zentrales Problem ist dabei das Verständnis unbekannter Attributnamen in Quell- und Zieldatenbanken und ETL Transformationen. Schwer verständliche Attributnamen führen zu Frustration und hohen Zeitaufwänden bei der Entwicklung und dem Verständnis von ETL Workflows. Wir präsentieren eine Schema Decryption Technik, die ETL Entwicklern das Verständnis kryptischer Schemata in Quell- und Zieldatenbanken und ETL Transformationen erleichtert. Unser Ansatz berücksichtigt für ein gegebenes ETL System die Vielzahl verknüpfter Attributnamen in den existierenden ETL Workflows. So werden gute und aussagekräftige "Decryptions" gefunden und wir sind in der Lage Attributnamen, die aus unbekannten Abkürzungen bestehen, zu "decrypten". So wird z.B. für den Attributenamen UNP_PEN_INT als Decryption UNPAIN_PENALTY_INTEREST vorgeschlagen. Unser Schema Decryption Ansatz wurde für drei ETL-Repositories evaluiert und es zeigte sich, dass unser Ansatz qualitativ hochwertige Decryptions für kryptische Attributnamen vorschlägt. T3 - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 60 KW - Extract-Transform-Load (ETL) KW - Data Warehouse KW - Datenintegration KW - Extract-Transform-Load (ETL) KW - Data Warehouse KW - Data Integration Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-61257 SN - 978-3-86956-201-8 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - THES A1 - Albrecht, Alexander T1 - Understanding and managing extract-transform-load systems Y1 - 2013 ER - TY - JOUR A1 - Borchert, Florian A1 - Mock, Andreas A1 - Tomczak, Aurelie A1 - Hügel, Jonas A1 - Alkarkoukly, Samer A1 - Knurr, Alexander A1 - Volckmar, Anna-Lena A1 - Stenzinger, Albrecht A1 - Schirmacher, Peter A1 - Debus, Jürgen A1 - Jäger, Dirk A1 - Longerich, Thomas A1 - Fröhling, Stefan A1 - Eils, Roland A1 - Bougatf, Nina A1 - Sax, Ulrich A1 - Schapranow, Matthieu-Patrick T1 - Correction to: Knowledge bases and software support for variant interpretation in precision oncology JF - Briefings in bioinformatics Y1 - 2021 U6 - https://doi.org/10.1093/bib/bbab246 SN - 1467-5463 SN - 1477-4054 VL - 22 IS - 6 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Brinkmann, Kai Oliver A1 - Becker, Tim A1 - Zimmermann, Florian A1 - Kreusel, Cedric A1 - Gahlmann, Tobias A1 - Theisen, Manuel A1 - Haeger, Tobias A1 - Olthof, Selina A1 - Tückmantel, Christian A1 - Günster, M. A1 - Maschwitz, Timo A1 - Göbelsmann, Fabian A1 - Koch, Christine A1 - Hertel, Dirk A1 - Caprioglio, Pietro A1 - Peña-Camargo, Francisco A1 - Perdigón-Toro, Lorena A1 - Al-Ashouri, Amran A1 - Merten, Lena A1 - Hinderhofer, Alexander A1 - Gomell, Leonie A1 - Zhang, Siyuan A1 - Schreiber, Frank A1 - Albrecht, Steve A1 - Meerholz, Klaus A1 - Neher, Dieter A1 - Stolterfoht, Martin A1 - Riedl, Thomas T1 - Perovskite-organic tandem solar cells with indium oxide interconnect JF - Nature N2 - Multijunction solar cells can overcome the fundamental efficiency limits of single-junction devices. The bandgap tunability of metal halide perovskite solar cells renders them attractive for multijunction architectures(1). Combinations with silicon and copper indium gallium selenide (CIGS), as well as all-perovskite tandem cells, have been reported(2-5). Meanwhile, narrow-gap non-fullerene acceptors have unlocked skyrocketing efficiencies for organic solar cells(6,7). Organic and perovskite semiconductors are an attractive combination, sharing similar processing technologies. Currently, perovskite-organic tandems show subpar efficiencies and are limited by the low open-circuit voltage (V-oc) of wide-gap perovskite cells(8) and losses introduced by the interconnect between the subcells(9,10). Here we demonstrate perovskite-organic tandem cells with an efficiency of 24.0 per cent (certified 23.1 per cent) and a high V-oc of 2.15 volts. Optimized charge extraction layers afford perovskite subcells with an outstanding combination of high V-oc and fill factor. The organic subcells provide a high external quantum efficiency in the near-infrared and, in contrast to paradigmatic concerns about limited photostability of non-fullerene cells(11), show an outstanding operational stability if excitons are predominantly generated on the non-fullerene acceptor, which is the case in our tandems. The subcells are connected by an ultrathin (approximately 1.5 nanometres) metal-like indium oxide layer with unprecedented low optical/electrical losses. This work sets a milestone for perovskite-organic tandems, which outperform the best p-i-n perovskite single junctions(12) and are on a par with perovskite-CIGS and all-perovskite multijunctions(13). Y1 - 2022 U6 - https://doi.org/10.1038/s41586-022-04455-0 SN - 0028-0836 SN - 1476-4687 VL - 604 IS - 7905 SP - 280 EP - 286 PB - Nature Research CY - Berlin ER - TY - JOUR A1 - Borchert, Florian A1 - Mock, Andreas A1 - Tomczak, Aurelie A1 - Hügel, Jonas A1 - Alkarkoukly, Samer A1 - Knurr, Alexander A1 - Volckmar, Anna-Lena A1 - Stenzinger, Albrecht A1 - Schirmacher, Peter A1 - Debus, Jürgen A1 - Jäger, Dirk A1 - Longerich, Thomas A1 - Fröhling, Stefan A1 - Eils, Roland A1 - Bougatf, Nina A1 - Sax, Ulrich A1 - Schapranow, Matthieu-Patrick T1 - Knowledge bases and software support for variant interpretation in precision oncology JF - Briefings in bioinformatics N2 - Precision oncology is a rapidly evolving interdisciplinary medical specialty. Comprehensive cancer panels are becoming increasingly available at pathology departments worldwide, creating the urgent need for scalable cancer variant annotation and molecularly informed treatment recommendations. A wealth of mainly academia-driven knowledge bases calls for software tools supporting the multi-step diagnostic process. We derive a comprehensive list of knowledge bases relevant for variant interpretation by a review of existing literature followed by a survey among medical experts from university hospitals in Germany. In addition, we review cancer variant interpretation tools, which integrate multiple knowledge bases. We categorize the knowledge bases along the diagnostic process in precision oncology and analyze programmatic access options as well as the integration of knowledge bases into software tools. The most commonly used knowledge bases provide good programmatic access options and have been integrated into a range of software tools. For the wider set of knowledge bases, access options vary across different parts of the diagnostic process. Programmatic access is limited for information regarding clinical classifications of variants and for therapy recommendations. The main issue for databases used for biological classification of pathogenic variants and pathway context information is the lack of standardized interfaces. There is no single cancer variant interpretation tool that integrates all identified knowledge bases. Specialized tools are available and need to be further developed for different steps in the diagnostic process. KW - HiGHmed KW - personalized medicine KW - molecular tumor board KW - data integration KW - cancer therapy Y1 - 2021 U6 - https://doi.org/10.1093/bib/bbab134 SN - 1467-5463 SN - 1477-4054 VL - 22 IS - 6 PB - Oxford Univ. Press CY - Oxford ER -