TY - JOUR
A1 - Abdalla, H.
A1 - Adam, R.
A1 - Aharonian, Felix A.
A1 - Benkhali, F. Ait
A1 - Angüner, Ekrem Oǧuzhan
A1 - Arcaro, C.
A1 - Armand, C.
A1 - Armstrong, T.
A1 - Ashkar, H.
A1 - Backes, M.
A1 - Baghmanyan, V.
A1 - Martins, V. Barbosa
A1 - Barnacka, A.
A1 - Barnard, M.
A1 - Becherini, Y.
A1 - Berge, D.
A1 - Bernlohr, K.
A1 - Bi, B.
A1 - Bottcher, M.
A1 - Boisson, C.
A1 - Bolmont, J.
A1 - de Lavergne, M. de Bony
A1 - Bordas, Pol
A1 - Breuhaus, M.
A1 - Brun, F.
A1 - Brun, P.
A1 - Bryan, M.
A1 - Buchele, M.
A1 - Bulik, T.
A1 - Bylund, T.
A1 - Caroff, S.
A1 - Carosi, A.
A1 - Casanova, Sabrina
A1 - Chand, T.
A1 - Chandra, S.
A1 - Chen, A.
A1 - Cotter, G.
A1 - Curylo, M.
A1 - Mbarubucyeye, J. Damascene
A1 - Davids, I. D.
A1 - Davies, J.
A1 - Deil, C.
A1 - Devin, J.
A1 - deWilt, P.
A1 - Dirson, L.
A1 - Djannati-Atai, A.
A1 - Dmytriiev, A.
A1 - Donath, A.
A1 - Doroshenko, V.
A1 - Duffy, C.
A1 - Dyks, J.
A1 - Egberts, Kathrin
A1 - Eichhorn, F.
A1 - Einecke, S.
A1 - Emery, G.
A1 - Ernenwein, J. -P.
A1 - Feijen, K.
A1 - Fegan, S.
A1 - Fiasson, A.
A1 - de Clairfontaine, G. Fichet
A1 - Fontaine, G.
A1 - Funk, S.
A1 - Fussling, Matthias
A1 - Gabici, S.
A1 - Gallant, Y. A.
A1 - Giavitto, G.
A1 - Giunti, L.
A1 - Glawion, D.
A1 - Glicenstein, J. F.
A1 - Gottschall, D.
A1 - Grondin, M. -H.
A1 - Hahn, J.
A1 - Haupt, M.
A1 - Hermann, G.
A1 - Hinton, J. A.
A1 - Hofmann, W.
A1 - Hoischen, Clemens
A1 - Holch, T. L.
A1 - Holler, M.
A1 - Horbe, M.
A1 - Horns, D.
A1 - Huber, D.
A1 - Jamrozy, M.
A1 - Jankowsky, D.
A1 - Jankowsky, F.
A1 - Jardin-Blicq, A.
A1 - Joshi, V.
A1 - Jung-Richardt, I.
A1 - Kasai, E.
A1 - Kastendieck, M. A.
A1 - Katarzynski, K.
A1 - Katz, U.
A1 - Khangulyan, D.
A1 - Khelifi, B.
A1 - Klepser, S.
A1 - Kluzniak, W.
A1 - Komin, Nu.
A1 - Konno, R.
A1 - Kosack, K.
A1 - Kostunin, D.
A1 - Kreter, M.
A1 - Lamanna, G.
A1 - Lemiere, A.
A1 - Lemoine-Goumard, M.
A1 - Lenain, J. -P.
A1 - Levy, C.
A1 - Lohse, T.
A1 - Lypova, I.
A1 - Mackey, J.
A1 - Majumdar, J.
A1 - Malyshev, D.
A1 - Malyshev, D.
A1 - Marandon, V.
A1 - Marchegiani, P.
A1 - Marcowith, Alexandre
A1 - Mares, A.
A1 - Marti-Devesa, G.
A1 - Marx, R.
A1 - Maurin, G.
A1 - Meintjes, P. J.
A1 - Meyer, M.
A1 - Mitchell, A.
A1 - Moderski, R.
A1 - Mohamed, M.
A1 - Mohrmann, L.
A1 - Montanari, A.
A1 - Moore, C.
A1 - Morris, P.
A1 - Moulin, Emmanuel
A1 - Muller, J.
A1 - Murach, T.
A1 - Nakashima, K.
A1 - Nayerhoda, A.
A1 - de Naurois, M.
A1 - Ndiyavala, H.
A1 - Niederwanger, F.
A1 - Niemiec, J.
A1 - Oakes, L.
A1 - O'Brien, Patrick
A1 - Odaka, H.
A1 - Ohm, S.
A1 - Olivera-Nieto, L.
A1 - Wilhelmi, E. de Ona
A1 - Ostrowski, M.
A1 - Oya, I.
A1 - Panter, M.
A1 - Panny, S.
A1 - Parsons, R. D.
A1 - Peron, G.
A1 - Peyaud, B.
A1 - Piel, Q.
A1 - Pita, S.
A1 - Poireau, V.
A1 - Noel, A. Priyana
A1 - Prokhorov, D. A.
A1 - Prokoph, H.
A1 - Puhlhofer, G.
A1 - Punch, M.
A1 - Quirrenbach, A.
A1 - Raab, S.
A1 - Rauth, R.
A1 - Reichherzer, P.
A1 - Reimer, A.
A1 - Reimer, O.
A1 - Remy, Q.
A1 - Renaud, M.
A1 - Rieger, F.
A1 - Rinchiuso, L.
A1 - Romoli, C.
A1 - Rowell, G.
A1 - Rudak, B.
A1 - Ruiz-Velasco, E.
A1 - Sahakian, V.
A1 - Sailer, S.
A1 - Sanchez, D. A.
A1 - Santangelo, Andrea
A1 - Sasaki, M.
A1 - Scalici, M.
A1 - Schussler, F.
A1 - Schutte, H. M.
A1 - Schwanke, U.
A1 - Schwemmer, S.
A1 - Seglar-Arroyo, M.
A1 - Senniappan, M.
A1 - Seyffert, A. S.
A1 - Shafi, N.
A1 - Shiningayamwe, K.
A1 - Simoni, R.
A1 - Sinha, A.
A1 - Sol, H.
A1 - Specovius, A.
A1 - Spencer, S.
A1 - Spir-Jacob, M.
A1 - Stawarz, L.
A1 - Sun, L.
A1 - Steenkamp, R.
A1 - Stegmann, C.
A1 - Steinmassl, S.
A1 - Steppa, C.
A1 - Takahashi, T.
A1 - Tavernier, T.
A1 - Taylor, A. M.
A1 - Terrier, R.
A1 - Tiziani, D.
A1 - Tluczykont, M.
A1 - Tomankova, L.
A1 - Trichard, C.
A1 - Tsirou, M.
A1 - Tuffs, R.
A1 - Uchiyama, Y.
A1 - van der Walt, D. J.
A1 - van Eldik, C.
A1 - van Rensburg, C.
A1 - van Soelen, B.
A1 - Vasileiadis, G.
A1 - Veh, J.
A1 - Venter, C.
A1 - Vincent, P.
A1 - Vink, J.
A1 - Volk, H. J.
A1 - Vuillaume, T.
A1 - Wadiasingh, Z.
A1 - Wagner, S. J.
A1 - Watson, J.
A1 - Werner, F.
A1 - White, R.
A1 - Wierzcholska, A.
A1 - Wong, Yu Wun
A1 - Yusafzai, A.
A1 - Zacharias, M.
A1 - Zanin, R.
A1 - Zargaryan, D.
A1 - Zdziarski, A. A.
A1 - Zech, Alraune
A1 - Zhu, S. J.
A1 - Ziegler, A.
A1 - Zorn, J.
A1 - Zouari, S.
A1 - Zywucka, N.
T1 - An extreme particle accelerator in the Galactic plane
BT - HESS J1826-130
JF - Astronomy and astrophysics : an international weekly journal
N2 - The unidentified very-high-energy (VHE; E > 0.1 TeV) gamma -ray source, HESS J1826-130, was discovered with the High Energy Stereoscopic System (HESS) in the Galactic plane. The analysis of 215 h of HESS data has revealed a steady gamma -ray flux from HESS J1826-130, which appears extended with a half-width of 0.21 degrees +/- 0.02
(stat)degrees
stat degrees +/- 0.05
(sys)degrees sys degrees . The source spectrum is best fit with either a power-law function with a spectral index Gamma = 1.78 +/- 0.10(stat) +/- 0.20(sys) and an exponential cut-off at 15.2
(+5.5)(-3.2) -3.2+5.5 TeV, or a broken power-law with Gamma (1) = 1.96 +/- 0.06(stat) +/- 0.20(sys), Gamma (2) = 3.59 +/- 0.69(stat) +/- 0.20(sys) for energies below and above E-br = 11.2 +/- 2.7 TeV, respectively. The VHE flux from HESS J1826-130 is contaminated by the extended emission of the bright, nearby pulsar wind nebula, HESS J1825-137, particularly at the low end of the energy spectrum. Leptonic scenarios for the origin of HESS J1826-130 VHE emission related to PSR J1826-1256 are confronted by our spectral and morphological analysis. In a hadronic framework, taking into account the properties of dense gas regions surrounding HESS J1826-130, the source spectrum would imply an astrophysical object capable of accelerating the parent particle population up to greater than or similar to 200 TeV. Our results are also discussed in a multiwavelength context, accounting for both the presence of nearby supernova remnants, molecular clouds, and counterparts detected in radio, X-rays, and TeV energies.
KW - ISM: supernova remnants
KW - ISM: clouds
KW - gamma rays: general
KW - gamma rays:
KW - ISM
Y1 - 2020
U6 - https://doi.org/10.1051/0004-6361/202038851
SN - 0004-6361
SN - 1432-0746
VL - 644
PB - EDP Sciences
CY - Les Ulis
ER -
TY - JOUR
A1 - Abdalla, Hassan E.
A1 - Adam, R.
A1 - Aharonian, Felix A.
A1 - Benkhali, F. Ait
A1 - Angüner, Ekrem Oǧuzhan
A1 - Arakawa, M.
A1 - Arcaro, C.
A1 - Armand, C.
A1 - Ashkar, H.
A1 - Backes, M.
A1 - Martins, V. Barbosa
A1 - Barnard, M.
A1 - Becherini, Y.
A1 - Berge, D.
A1 - Bernloehr, K.
A1 - Bissaldi, E.
A1 - Blackwell, R.
A1 - Boettcher, M.
A1 - Boisson, C.
A1 - Bolmont, J.
A1 - Bonnefoy, S.
A1 - Bregeon, J.
A1 - Breuhaus, M.
A1 - Brun, F.
A1 - Brun, P.
A1 - Bryan, M.
A1 - Buechele, M.
A1 - Bulik, T.
A1 - Bylund, T.
A1 - Capasso, M.
A1 - Caroff, S.
A1 - Carosi, A.
A1 - Casanova, Sabrina
A1 - Cerruti, M.
A1 - Chand, T.
A1 - Chandra, S.
A1 - Chen, A.
A1 - Colafrancesco, S.
A1 - Curylo, M.
A1 - Davids, I. D.
A1 - Deil, C.
A1 - Devin, J.
A1 - deWilt, P.
A1 - Dirson, L.
A1 - Djannati-Atai, A.
A1 - Dmytriiev, A.
A1 - Donath, A.
A1 - Doroshenko, V
A1 - Dyks, J.
A1 - Egberts, Kathrin
A1 - Emery, G.
A1 - Ernenwein, J-P
A1 - Eschbach, S.
A1 - Feijen, K.
A1 - Fegan, S.
A1 - Fiasson, A.
A1 - Fontaine, G.
A1 - Funk, S.
A1 - Fussling, Matthias
A1 - Gabici, S.
A1 - Gallant, Y. A.
A1 - Gate, F.
A1 - Giavitto, G.
A1 - Giunti, L.
A1 - Glawion, D.
A1 - Glicenstein, J. F.
A1 - Gottschall, D.
A1 - Grondin, M-H
A1 - Hahn, J.
A1 - Haupt, M.
A1 - Heinzelmann, G.
A1 - Henri, G.
A1 - Hermann, G.
A1 - Hinton, J. A.
A1 - Hofmann, W.
A1 - Hoischen, Clemens
A1 - Holch, T. L.
A1 - Holler, M.
A1 - Horns, D.
A1 - Huber, D.
A1 - Iwasaki, H.
A1 - Jamrozy, M.
A1 - Jankowsky, D.
A1 - Jankowsky, F.
A1 - Jardin-Blicq, A.
A1 - Jung-Richardt, I
A1 - Kastendieck, M. A.
A1 - Katarzynski, K.
A1 - Katsuragawa, M.
A1 - Katz, U.
A1 - Khangulyan, D.
A1 - Khelifi, B.
A1 - King, J.
A1 - Klepser, S.
A1 - Kluzniak, W.
A1 - Komin, Nu
A1 - Kosack, K.
A1 - Kostunin, D.
A1 - Kreter, M.
A1 - Lamanna, G.
A1 - Lemiere, A.
A1 - Lemoine-Goumard, M.
A1 - Lenain, J-P
A1 - Leser, Eva
A1 - Levy, C.
A1 - Lohse, T.
A1 - Lypova, I
A1 - Mackey, J.
A1 - Majumdar, J.
A1 - Malyshev, D.
A1 - Marandon, V
A1 - Marcowith, Alexandre
A1 - Mares, A.
A1 - Mariaud, C.
A1 - Marti-Devesa, G.
A1 - Marx, R.
A1 - Maurin, G.
A1 - Meintjes, P. J.
A1 - Mitchell, A. M. W.
A1 - Moderski, R.
A1 - Mohamed, M.
A1 - Mohrmann, L.
A1 - Moore, C.
A1 - Moulin, Emmanuel
A1 - Muller, J.
A1 - Murach, T.
A1 - Nakashima, S.
A1 - de Naurois, M.
A1 - Ndiyavala, H.
A1 - Niederwanger, F.
A1 - Niemiec, J.
A1 - Oakes, L.
A1 - Odaka, H.
A1 - Ohm, S.
A1 - Wilhelmi, E. de Ona
A1 - Ostrowski, M.
A1 - Oya, I
A1 - Panter, M.
A1 - Parsons, R. D.
A1 - Perennes, C.
A1 - Petrucci, P-O
A1 - Peyaud, B.
A1 - Piel, Q.
A1 - Pita, S.
A1 - Poireau, V
A1 - Noel, A. Priyana
A1 - Prokhorov, D. A.
A1 - Prokoph, H.
A1 - Puehlhofer, G.
A1 - Punch, M.
A1 - Quirrenbach, A.
A1 - Raab, S.
A1 - Rauth, R.
A1 - Reimer, A.
A1 - Reimer, O.
A1 - Remy, Q.
A1 - Renaud, M.
A1 - Rieger, F.
A1 - Rinchiuso, L.
A1 - Romoli, C.
A1 - Rowell, G.
A1 - Rudak, B.
A1 - Ruiz-Velasco, E.
A1 - Sahakian, V
A1 - Sailer, S.
A1 - Saito, S.
A1 - Sanchez, D. A.
A1 - Santangelo, Andrea
A1 - Sasaki, M.
A1 - Schlickeiser, R.
A1 - Schussler, F.
A1 - Schulz, A.
A1 - Schutte, H. M.
A1 - Schwanke, U.
A1 - Schwemmer, S.
A1 - Seglar-Arroyo, M.
A1 - Senniappan, M.
A1 - Seyffert, A. S.
A1 - Shafi, N.
A1 - Shiningayamwe, K.
A1 - Simoni, R.
A1 - Sinha, A.
A1 - Sol, H.
A1 - Specovius, A.
A1 - Spir-Jacob, M.
A1 - Stawarz, L.
A1 - Steenkamp, R.
A1 - Stegmann, Christian
A1 - Steppa, Constantin Beverly
A1 - Takahashi, T.
A1 - Tavernier, T.
A1 - Taylor, A. M.
A1 - Terrier, R.
A1 - Tiziani, D.
A1 - Tluczykont, M.
A1 - Trichard, C.
A1 - Tsirou, M.
A1 - Tsuji, N.
A1 - Tuffs, R.
A1 - Uchiyama, Y.
A1 - van der Walt, D. J.
A1 - van Eldik, C.
A1 - van Rensburg, C.
A1 - van Soelen, B.
A1 - Vasileiadis, G.
A1 - Veh, J.
A1 - Venter, C.
A1 - Vincent, P.
A1 - Vink, J.
A1 - Voelk, H. J.
A1 - Vuillaume, T.
A1 - Wadiasingh, Z.
A1 - Wagner, S. J.
A1 - White, R.
A1 - Wierzcholska, A.
A1 - Yang, R.
A1 - Yoneda, H.
A1 - Zacharias, M.
A1 - Zanin, R.
A1 - Zdziarski, A. A.
A1 - Zech, Alraune
A1 - Ziegler, A.
A1 - Zorn, J.
A1 - Zywucka, N.
A1 - de Palma, F.
A1 - Axelsson, M.
A1 - Roberts, O. J.
T1 - A very-high-energy component deep in the gamma-ray burst afterglow
JF - Nature : the international weekly journal of science
N2 - Gamma-ray bursts (GRBs) are brief flashes of gamma-rays and are considered to be the most energetic explosive phenomena in the Universe(1). The emission from GRBs comprises a short (typically tens of seconds) and bright prompt emission, followed by a much longer afterglow phase. During the afterglow phase, the shocked outflow-produced by the interaction between the ejected matter and the circumburst medium-slows down, and a gradual decrease in brightness is observed(2). GRBs typically emit most of their energy via.-rays with energies in the kiloelectronvolt-to-megaelectronvolt range, but a few photons with energies of tens of gigaelectronvolts have been detected by space-based instruments(3). However, the origins of such high-energy (above one gigaelectronvolt) photons and the presence of very-high-energy (more than 100 gigaelectronvolts) emission have remained elusive(4). Here we report observations of very-high-energy emission in the bright GRB 180720B deep in the GRB afterglow-ten hours after the end of the prompt emission phase, when the X-ray flux had already decayed by four orders of magnitude. Two possible explanations exist for the observed radiation: inverse Compton emission and synchrotron emission of ultrarelativistic electrons. Our observations show that the energy fluxes in the X-ray and gamma-ray range and their photon indices remain comparable to each other throughout the afterglow. This discovery places distinct constraints on the GRB environment for both emission mechanisms, with the inverse Compton explanation alleviating the particle energy requirements for the emission observed at late times. The late timing of this detection has consequences for the future observations of GRBs at the highest energies.
Y1 - 2019
U6 - https://doi.org/10.1038/s41586-019-1743-9
SN - 0028-0836
SN - 1476-4687
VL - 575
IS - 7783
SP - 464
EP - +
PB - Nature Publ. Group
CY - London
ER -
TY - JOUR
A1 - Abdalla, Hassan E.
A1 - Adam, R.
A1 - Aharonian, Felix A.
A1 - Benkhali, F. Ait
A1 - Angüner, Ekrem Oǧuzhan
A1 - Arakawa, M.
A1 - Arcaro, C.
A1 - Armand, C.
A1 - Ashkar, H.
A1 - Backes, M.
A1 - Martins, V. Barbosa
A1 - Barnard, M.
A1 - Becherini, Y.
A1 - Berge, D.
A1 - Bernloehr, K.
A1 - Blackwell, R.
A1 - Böttcher, M.
A1 - Boisson, C.
A1 - Bolmont, J.
A1 - Bonnefoy, S.
A1 - Bregeon, J.
A1 - Breuhaus, M.
A1 - Brun, F.
A1 - Brun, P.
A1 - Bryan, M.
A1 - Büchele, M.
A1 - Bulik, T.
A1 - Bylund, T.
A1 - Capasso, M.
A1 - Caroff, S.
A1 - Carosi, A.
A1 - Casanova, Sabrina
A1 - Cerruti, M.
A1 - Chand, T.
A1 - Chandra, S.
A1 - Chen, A.
A1 - Colafrancesco, S.
A1 - Curylo, M.
A1 - Davids, I. D.
A1 - Deil, C.
A1 - Devin, J.
A1 - DeWilt, P.
A1 - Dirson, L.
A1 - Djannati-Ata, A.
A1 - Dmytriiev, A.
A1 - Donath, A.
A1 - Doroshenko, V
A1 - Dyks, J.
A1 - Egberts, Kathrin
A1 - Emery, G.
A1 - Ernenwein, J-P
A1 - Eschbach, S.
A1 - Feijen, K.
A1 - Fegan, S.
A1 - Fiasson, A.
A1 - Fontaine, G.
A1 - Funk, S.
A1 - Füßling, Matthias
A1 - Gabici, S.
A1 - Gallant, Y. A.
A1 - Gate, F.
A1 - Giavitto, G.
A1 - Glawion, D.
A1 - Glicenstein, J. F.
A1 - Gottschall, D.
A1 - Grondin, M-H
A1 - Hahn, J.
A1 - Haupt, M.
A1 - Heinzelmann, G.
A1 - Henri, G.
A1 - Hermann, G.
A1 - Hinton, James Anthony
A1 - Hofmann, W.
A1 - Hoischen, Clemens
A1 - Holch, Tim Lukas
A1 - Holler, M.
A1 - Horns, D.
A1 - Huber, D.
A1 - Iwasaki, H.
A1 - Jamrozy, M.
A1 - Jankowsky, D.
A1 - Jankowsky, F.
A1 - Jardin-Blicq, A.
A1 - Jung-Richardt, I
A1 - Kastendieck, M. A.
A1 - Katarzynski, K.
A1 - Katsuragawa, M.
A1 - Katz, U.
A1 - Khangulyan, D.
A1 - Khelifi, B.
A1 - King, J.
A1 - Klepser, S.
A1 - Kluzniak, W.
A1 - Komin, Nu
A1 - Kosack, K.
A1 - Kostunin, D.
A1 - Kraus, M.
A1 - Lamanna, G.
A1 - Lau, J.
A1 - Lemiere, A.
A1 - Lemoine-Goumard, M.
A1 - Lenain, J-P
A1 - Leser, Eva
A1 - Levy, C.
A1 - Lohse, T.
A1 - Lypova, I
A1 - Mackey, J.
A1 - Majumdar, J.
A1 - Malyshev, D.
A1 - Marandon, V
A1 - Marcowith, Alexandre
A1 - Mares, A.
A1 - Mariaud, C.
A1 - Marti-Devesa, G.
A1 - Marx, R.
A1 - Maurin, G.
A1 - Meintjes, P. J.
A1 - Mitchell, A. M. W.
A1 - Moderski, R.
A1 - Mohamed, M.
A1 - Mohrmann, L.
A1 - Moore, C.
A1 - Moulin, Emmanuel
A1 - Muller, J.
A1 - Murach, T.
A1 - Nakashima, S.
A1 - de Naurois, M.
A1 - Ndiyavala, H.
A1 - Niederwanger, F.
A1 - Niemiec, J.
A1 - Oakes, L.
A1 - Odaka, H.
A1 - Ohm, S.
A1 - Wilhelmi, E. de Ona
A1 - Ostrowski, M.
A1 - Oya, I
A1 - Panter, M.
A1 - Parsons, R. D.
A1 - Perennes, C.
A1 - Petrucci, P-O
A1 - Peyaud, B.
A1 - Piel, Q.
A1 - Pita, S.
A1 - Poireau, V
A1 - Priyana Noel, A.
A1 - Prokhorov, D. A.
A1 - Prokoph, H.
A1 - Pühlhofer, G.
A1 - Punch, M.
A1 - Quirrenbach, A.
A1 - Raab, S.
A1 - Rauth, R.
A1 - Reimer, A.
A1 - Reimer, O.
A1 - Remy, Q.
A1 - Renaud, M.
A1 - Rieger, F.
A1 - Rinchiuso, L.
A1 - Romoli, C.
A1 - Rowell, G.
A1 - Rudak, B.
A1 - Ruiz-Velasco, E.
A1 - Sahakian, V
A1 - Saito, S.
A1 - Sanchez, David M.
A1 - Santangelo, Andrea
A1 - Sasaki, M.
A1 - Schlickeiser, R.
A1 - Schüssler, F.
A1 - Schulz, A.
A1 - Schutte, H.
A1 - Schwanke, U.
A1 - Schwemmer, S.
A1 - Seglar-Arroyo, M.
A1 - Senniappan, M.
A1 - Seyffert, A. S.
A1 - Shafi, N.
A1 - Shiningayamwe, K.
A1 - Simoni, R.
A1 - Sinha, A.
A1 - Sol, H.
A1 - Specovius, A.
A1 - Spir-Jacob, M.
A1 - Stawarz, L.
A1 - Steenkamp, R.
A1 - Stegmann, Christian
A1 - Steppa, Constantin Beverly
A1 - Takahashi, T.
A1 - Tavernier, T.
A1 - Taylor, A. M.
A1 - Terrier, R.
A1 - Tiziani, D.
A1 - Tluczykont, M.
A1 - Trichard, C.
A1 - Tsirou, M.
A1 - Tsuji, N.
A1 - Tuffs, R.
A1 - Uchiyama, Y.
A1 - van Der Walt, D. J.
A1 - van Eldik, C.
A1 - van Rensburg, C.
A1 - van Soelen, B.
A1 - Vasileiadis, G.
A1 - Veh, J.
A1 - Venter, C.
A1 - Vincent, P.
A1 - Vink, J.
A1 - Voisin, F.
A1 - Voelk, H. J.
A1 - Vuillaume, T.
A1 - Wadiasingh, Z.
A1 - Wagner, S. J.
A1 - White, R.
A1 - Wierzcholska, A.
A1 - Yang, R.
A1 - Yoneda, H.
A1 - Zacharias, Michael
A1 - Zanin, R.
A1 - Zdziarski, A. A.
A1 - Zech, Alraune
A1 - Ziegler, A.
A1 - Zorn, J.
A1 - Zywucka, N.
A1 - Meyer, M.
T1 - Constraints on the emission region of 3C 279 during strong flares in 2014 and 2015 through VHE gamma-ray observations with HESS
JF - Astronomy and astrophysics : an international weekly journal
N2 - The flat spectrum radio quasar 3C 279 is known to exhibit pronounced variability in the high-energy (100MeV < E < 100 GeV) gamma-ray band, which is continuously monitored with Fermi-LAT. During two periods of high activity in April 2014 and June 2015 target-of-opportunity observations were undertaken with the High Energy Stereoscopic System (H.E.S.S.) in the very-high-energy (VHE, E > 100 GeV) gamma-ray domain. While the observation in 2014 provides an upper limit, the observation in 2015 results in a signal with 8 : 7 sigma significance above an energy threshold of 66 GeV. No VHE variability was detected during the 2015 observations. The VHE photon spectrum is soft and described by a power-law index of 4.2 +/- 0.3. The H.E.S.S. data along with a detailed and contemporaneous multiwavelength data set provide constraints on the physical parameters of the emission region. The minimum distance of the emission region from the central black hole was estimated using two plausible geometries of the broad-line region and three potential intrinsic spectra. The emission region is confidently placed at r greater than or similar to 1 : 7 X 1017 cm from the black hole, that is beyond the assumed distance of the broad-line region. Time-dependent leptonic and lepto-hadronic one-zone models were used to describe the evolution of the 2015 flare. Neither model can fully reproduce the observations, despite testing various parameter sets. Furthermore, the H.E.S.S. data were used to derive constraints on Lorentz invariance violation given the large redshift of 3C 279.
KW - radiation mechanisms: non-thermal
KW - quasars: individual: 3C 279
KW - galaxies: active
KW - relativistic processes
Y1 - 2019
U6 - https://doi.org/10.1051/0004-6361/201935704
SN - 1432-0746
VL - 627
PB - EDP Sciences
CY - Les Ulis
ER -
TY - JOUR
A1 - Abdalla, Hassan E.
A1 - Aharonian, Felix A.
A1 - Benkhali, F. Ait
A1 - Anguener, E. O.
A1 - Arakawa, M.
A1 - Arcaro, C.
A1 - Armand, C.
A1 - Ashkar, H.
A1 - Backes, M.
A1 - Martins, V. Barbosa
A1 - Barnard, M.
A1 - Becherini, Y.
A1 - Berge, D.
A1 - Bernloehr, K.
A1 - Blackwell, R.
A1 - Boettcher, M.
A1 - Boisson, C.
A1 - Bolmont, J.
A1 - Bonnefoy, S.
A1 - Bregeon, J.
A1 - Breuhaus, M.
A1 - Brun, F.
A1 - Brun, P.
A1 - Bryan, M.
A1 - Buechele, M.
A1 - Bulik, T.
A1 - Bylund, T.
A1 - Capasso, M.
A1 - Caroff, S.
A1 - Carosi, A.
A1 - Casanova, Sabrina
A1 - Cerruti, M.
A1 - Chakraborty, N.
A1 - Chand, T.
A1 - Chandra, S.
A1 - Chaves, R. C. G.
A1 - Chen, A.
A1 - Colafrancesco, S.
A1 - Curylo, M.
A1 - Davids, I. D.
A1 - Deil, C.
A1 - Devin, J.
A1 - de Wilt, P.
A1 - Dirson, L.
A1 - Djannati-Atai, A.
A1 - Dmytriiev, A.
A1 - Donath, A.
A1 - Doroshenko, V
A1 - Dyks, J.
A1 - Egberts, Kathrin
A1 - Emery, G.
A1 - Ernenwein, J-p
A1 - Eschbach, S.
A1 - Feijen, K.
A1 - Fegan, S.
A1 - Fiasson, A.
A1 - Fontaine, G.
A1 - Funk, S.
A1 - Fuessling, M.
A1 - Gabici, S.
A1 - Gallant, Y. A.
A1 - Gate, F.
A1 - Giavitto, G.
A1 - Glawion, D.
A1 - Glicenstein, J. F.
A1 - Gottschall, D.
A1 - Grondin, M-H
A1 - Hahn, J.
A1 - Haupt, M.
A1 - Heinzelmann, G.
A1 - Henri, G.
A1 - Hermann, G.
A1 - Hinton, James Anthony
A1 - Hofmann, W.
A1 - Hoischen, Clemens
A1 - Holch, Tim Lukas
A1 - Holler, M.
A1 - Horns, D.
A1 - Huber, D.
A1 - Iwasaki, H.
A1 - Jamrozy, M.
A1 - Jankowsky, D.
A1 - Jankowsky, F.
A1 - Jung-Richardt, I
A1 - Kastendieck, M. A.
A1 - Katarzynski, K.
A1 - Katsuragawa, M.
A1 - Katz, U.
A1 - Khangulyan, D.
A1 - Khelifi, B.
A1 - King, J.
A1 - Klepser, S.
A1 - Kluzniak, W.
A1 - Komin, Nu
A1 - Kosack, K.
A1 - Kostunin, D.
A1 - Kraus, M.
A1 - Lamanna, G.
A1 - Lau, J.
A1 - Lemiere, A.
A1 - Lemoine-Goumard, M.
A1 - Lenain, J-P
A1 - Leser, Eva
A1 - Levy, C.
A1 - Lohse, T.
A1 - Lopez-Coto, R.
A1 - Lypova, I
A1 - Mackey, J.
A1 - Majumdar, J.
A1 - Malyshev, D.
A1 - Marandon, V
A1 - Marcowith, Alexandre
A1 - Mares, A.
A1 - Mariaud, C.
A1 - Marti-Devesa, G.
A1 - Marx, R.
A1 - Maurin, G.
A1 - Meintjes, P. J.
A1 - Mitchell, A. M. W.
A1 - Moderski, R.
A1 - Mohamed, M.
A1 - Mohrmann, L.
A1 - Muller, J.
A1 - Moore, C.
A1 - Moulin, Emmanuel
A1 - Murach, T.
A1 - Nakashima, S.
A1 - de Naurois, M.
A1 - Ndiyavala, H.
A1 - Niederwanger, F.
A1 - Niemiec, J.
A1 - Oakes, L.
A1 - Odaka, H.
A1 - Ohm, S.
A1 - Wilhelmi, E. de Ona
A1 - Ostrowski, M.
A1 - Oya, I
A1 - Panter, M.
A1 - Parsons, R. D.
A1 - Perennes, C.
A1 - Petrucci, P-O
A1 - Peyaud, B.
A1 - Piel, Q.
A1 - Pita, S.
A1 - Poireau, V
A1 - Noel, A. Priyana
A1 - Prokhorov, D. A.
A1 - Prokoph, H.
A1 - Puehlhofer, G.
A1 - Punch, M.
A1 - Quirrenbach, A.
A1 - Raab, S.
A1 - Rauth, R.
A1 - Reimer, A.
A1 - Reimer, O.
A1 - Remy, Q.
A1 - Renaud, M.
A1 - Rieger, F.
A1 - Rinchiuso, L.
A1 - Romoli, C.
A1 - Rowell, G.
A1 - Rudak, B.
A1 - Ruiz-Velasco, E.
A1 - Sahakian, V
A1 - Saito, S.
A1 - Sanchez, David M.
A1 - Santangelo, Andrea
A1 - Sasaki, M.
A1 - Schlickeiser, R.
A1 - Schussler, F.
A1 - Schulz, A.
A1 - Schutte, H.
A1 - Schwanke, U.
A1 - Schwemmer, S.
A1 - Seglar-Arroyo, M.
A1 - Senniappan, M.
A1 - Seyffert, A. S.
A1 - Shafi, N.
A1 - Shiningayamwe, K.
A1 - Simoni, R.
A1 - Sinha, A.
A1 - Sol, H.
A1 - Specovius, A.
A1 - Spir-Jacob, M.
A1 - Stawarz, L.
A1 - Steenkamp, R.
A1 - Stegmann, Christian
A1 - Steppa, Constantin Beverly
A1 - Takahashi, T.
A1 - Tavernier, T.
A1 - Taylor, A. M.
A1 - Terrier, R.
A1 - Tiziani, D.
A1 - Tluczykont, M.
A1 - Trichard, C.
A1 - Tsirou, M.
A1 - Tsuji, N.
A1 - Tuffs, R.
A1 - Uchiyama, Y.
A1 - van der Walt, D. J.
A1 - van Eldik, C.
A1 - van Rensburg, C.
A1 - van Soelen, B.
A1 - Vasileiadis, G.
A1 - Veh, J.
A1 - Venter, C.
A1 - Vincent, P.
A1 - Vink, J.
A1 - Voisin, F.
A1 - Voelk, H. J.
A1 - Vuillaume, T.
A1 - Wadiasingh, Z.
A1 - Wagner, S. J.
A1 - White, R.
A1 - Wierzcholska, A.
A1 - Yang, R.
A1 - Yoneda, H.
A1 - Zacharias, M.
A1 - Zanin, R.
A1 - Zdziarski, A. A.
A1 - Zech, Alraune
A1 - Ziegler, A.
A1 - Zorn, J.
A1 - Zywucka, N.
A1 - Maxted, N.
T1 - Upper limits on very-high-energy gamma-ray emission from core-collapse supernovae observed with H.E.S.S.
JF - Astronomy and astrophysics : an international weekly journal
N2 - Young core-collapse supernovae with dense-wind progenitors may be able to accelerate cosmic-ray hadrons beyond the knee of the cosmic-ray spectrum, and this may result in measurable gamma-ray emission. We searched for gamma-ray emission from ten super- novae observed with the High Energy Stereoscopic System (H.E.S.S.) within a year of the supernova event. Nine supernovae were observed serendipitously in the H.E.S.S. data collected between December 2003 and December 2014, with exposure times ranging from 1.4 to 53 h. In addition we observed SN 2016adj as a target of opportunity in February 2016 for 13 h. No significant gamma-ray emission has been detected for any of the objects, and upper limits on the >1 TeV gamma-ray flux of the order of similar to 10(-13) cm(-)(2)s(-1) are established, corresponding to upper limits on the luminosities in the range similar to 2 x 10(39) to similar to 1 x 10(42) erg s(-1). These values are used to place model-dependent constraints on the mass-loss rates of the progenitor stars, implying upper limits between similar to 2 x 10(-5) and similar to 2 x 10(-3) M-circle dot yr(-1) under reasonable assumptions on the particle acceleration parameters.
KW - gamma rays: general
KW - supernovae: general
KW - cosmic rays
Y1 - 2019
U6 - https://doi.org/10.1051/0004-6361/201935242
SN - 1432-0746
VL - 626
PB - EDP Sciences
CY - Les Ulis
ER -
TY - JOUR
A1 - Warrington, Nicole
A1 - Beaumont, Robin
A1 - Horikoshi, Momoko
A1 - Day, Felix R.
A1 - Helgeland, Øyvind
A1 - Laurin, Charles
A1 - Bacelis, Jonas
A1 - Peng, Shouneng
A1 - Hao, Ke
A1 - Feenstra, Bjarke
A1 - Wood, Andrew R.
A1 - Mahajan, Anubha
A1 - Tyrrell, Jessica
A1 - Robertson, Neil R.
A1 - Rayner, N. William
A1 - Qiao, Zhen
A1 - Moen, Gunn-Helen
A1 - Vaudel, Marc
A1 - Marsit, Carmen
A1 - Chen, Jia
A1 - Nodzenski, Michael
A1 - Schnurr, Theresia M.
A1 - Zafarmand, Mohammad Hadi
A1 - Bradfield, Jonathan P.
A1 - Grarup, Niels
A1 - Kooijman, Marjolein N.
A1 - Li-Gao, Ruifang
A1 - Geller, Frank
A1 - Ahluwalia, Tarunveer Singh
A1 - Paternoster, Lavinia
A1 - Rueedi, Rico
A1 - Huikari, Ville
A1 - Hottenga, Jouke-Jan
A1 - Lyytikäinen, Leo-Pekka
A1 - Cavadino, Alana
A1 - Metrustry, Sarah
A1 - Cousminer, Diana L.
A1 - Wu, Ying
A1 - Thiering, Elisabeth Paula
A1 - Wang, Carol A.
A1 - Have, Christian Theil
A1 - Vilor-Tejedor, Natalia
A1 - Joshi, Peter K.
A1 - Painter, Jodie N.
A1 - Ntalla, Ioanna
A1 - Myhre, Ronny
A1 - Pitkänen, Niina
A1 - van Leeuwen, Elisabeth M.
A1 - Joro, Raimo
A1 - Lagou, Vasiliki
A1 - Richmond, Rebecca C.
A1 - Espinosa, Ana
A1 - Barton, Sheila J.
A1 - Inskip, Hazel M.
A1 - Holloway, John W.
A1 - Santa-Marina, Loreto
A1 - Estivill, Xavier
A1 - Ang, Wei
A1 - Marsh, Julie A.
A1 - Reichetzeder, Christoph
A1 - Marullo, Letizia
A1 - Hocher, Berthold
A1 - Lunetta, Kathryn L.
A1 - Murabito, Joanne M.
A1 - Relton, Caroline L.
A1 - Kogevinas, Manolis
A1 - Chatzi, Leda
A1 - Allard, Catherine
A1 - Bouchard, Luigi
A1 - Hivert, Marie-France
A1 - Zhang, Ge
A1 - Muglia, Louis J.
A1 - Heikkinen, Jani
A1 - Morgen, Camilla S.
A1 - van Kampen, Antoine H. C.
A1 - van Schaik, Barbera D. C.
A1 - Mentch, Frank D.
A1 - Langenberg, Claudia
A1 - Scott, Robert A.
A1 - Zhao, Jing Hua
A1 - Hemani, Gibran
A1 - Ring, Susan M.
A1 - Bennett, Amanda J.
A1 - Gaulton, Kyle J.
A1 - Fernandez-Tajes, Juan
A1 - van Zuydam, Natalie R.
A1 - Medina-Gomez, Carolina
A1 - de Haan, Hugoline G.
A1 - Rosendaal, Frits R.
A1 - Kutalik, Zoltán
A1 - Marques-Vidal, Pedro
A1 - Das, Shikta
A1 - Willemsen, Gonneke
A1 - Mbarek, Hamdi
A1 - Müller-Nurasyid, Martina
A1 - Standl, Marie
A1 - Appel, Emil V. R.
A1 - Fonvig, Cilius Esmann
A1 - Trier, Caecilie
A1 - van Beijsterveldt, Catharina E. M.
A1 - Murcia, Mario
A1 - Bustamante, Mariona
A1 - Bonàs-Guarch, Sílvia
A1 - Hougaard, David M.
A1 - Mercader, Josep M.
A1 - Linneberg, Allan
A1 - Schraut, Katharina E.
A1 - Lind, Penelope A.
A1 - Medland, Sarah Elizabeth
A1 - Shields, Beverley M.
A1 - Knight, Bridget A.
A1 - Chai, Jin-Fang
A1 - Panoutsopoulou, Kalliope
A1 - Bartels, Meike
A1 - Sánchez, Friman
A1 - Stokholm, Jakob
A1 - Torrents, David
A1 - Vinding, Rebecca K.
A1 - Willems, Sara M.
A1 - Atalay, Mustafa
A1 - Chawes, Bo L.
A1 - Kovacs, Peter
A1 - Prokopenko, Inga
A1 - Tuke, Marcus A.
A1 - Yaghootkar, Hanieh
A1 - Ruth, Katherine S.
A1 - Jones, Samuel E.
A1 - Loh, Po-Ru
A1 - Murray, Anna
A1 - Weedon, Michael N.
A1 - Tönjes, Anke
A1 - Stumvoll, Michael
A1 - Michaelsen, Kim Fleischer
A1 - Eloranta, Aino-Maija
A1 - Lakka, Timo A.
A1 - van Duijn, Cornelia M.
A1 - Kiess, Wieland
A1 - Koerner, Antje
A1 - Niinikoski, Harri
A1 - Pahkala, Katja
A1 - Raitakari, Olli T.
A1 - Jacobsson, Bo
A1 - Zeggini, Eleftheria
A1 - Dedoussis, George V.
A1 - Teo, Yik-Ying
A1 - Saw, Seang-Mei
A1 - Montgomery, Grant W.
A1 - Campbell, Harry
A1 - Wilson, James F.
A1 - Vrijkotte, Tanja G. M.
A1 - Vrijheid, Martine
A1 - de Geus, Eco J. C. N.
A1 - Hayes, M. Geoffrey
A1 - Kadarmideen, Haja N.
A1 - Holm, Jens-Christian
A1 - Beilin, Lawrence J.
A1 - Pennell, Craig E.
A1 - Heinrich, Joachim
A1 - Adair, Linda S.
A1 - Borja, Judith B.
A1 - Mohlke, Karen L.
A1 - Eriksson, Johan G.
A1 - Widen, Elisabeth E.
A1 - Hattersley, Andrew T.
A1 - Spector, Tim D.
A1 - Kaehoenen, Mika
A1 - Viikari, Jorma S.
A1 - Lehtimaeki, Terho
A1 - Boomsma, Dorret I.
A1 - Sebert, Sylvain
A1 - Vollenweider, Peter
A1 - Sorensen, Thorkild I. A.
A1 - Bisgaard, Hans
A1 - Bonnelykke, Klaus
A1 - Murray, Jeffrey C.
A1 - Melbye, Mads
A1 - Nohr, Ellen A.
A1 - Mook-Kanamori, Dennis O.
A1 - Rivadeneira, Fernando
A1 - Hofman, Albert
A1 - Felix, Janine F.
A1 - Jaddoe, Vincent W. V.
A1 - Hansen, Torben
A1 - Pisinger, Charlotta
A1 - Vaag, Allan A.
A1 - Pedersen, Oluf
A1 - Uitterlinden, Andre G.
A1 - Jarvelin, Marjo-Riitta
A1 - Power, Christine
A1 - Hypponen, Elina
A1 - Scholtens, Denise M.
A1 - Lowe, William L.
A1 - Smith, George Davey
A1 - Timpson, Nicholas J.
A1 - Morris, Andrew P.
A1 - Wareham, Nicholas J.
A1 - Hakonarson, Hakon
A1 - Grant, Struan F. A.
A1 - Frayling, Timothy M.
A1 - Lawlor, Debbie A.
A1 - Njolstad, Pal R.
A1 - Johansson, Stefan
A1 - Ong, Ken K.
A1 - McCarthy, Mark I.
A1 - Perry, John R. B.
A1 - Evans, David M.
A1 - Freathy, Rachel M.
T1 - Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
JF - Nature genetics
N2 - Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.
Y1 - 2019
SN - 1061-4036
SN - 1546-1718
VL - 51
IS - 5
SP - 804
EP - +
PB - Nature Publ. Group
CY - New York
ER -
TY - JOUR
A1 - Aarts, Alexander A.
A1 - Anderson, Joanna E.
A1 - Anderson, Christopher J.
A1 - Attridge, Peter R.
A1 - Attwood, Angela
A1 - Axt, Jordan
A1 - Babel, Molly
A1 - Bahnik, Stepan
A1 - Baranski, Erica
A1 - Barnett-Cowan, Michael
A1 - Bartmess, Elizabeth
A1 - Beer, Jennifer
A1 - Bell, Raoul
A1 - Bentley, Heather
A1 - Beyan, Leah
A1 - Binion, Grace
A1 - Borsboom, Denny
A1 - Bosch, Annick
A1 - Bosco, Frank A.
A1 - Bowman, Sara D.
A1 - Brandt, Mark J.
A1 - Braswell, Erin
A1 - Brohmer, Hilmar
A1 - Brown, Benjamin T.
A1 - Brown, Kristina
A1 - Bruening, Jovita
A1 - Calhoun-Sauls, Ann
A1 - Callahan, Shannon P.
A1 - Chagnon, Elizabeth
A1 - Chandler, Jesse
A1 - Chartier, Christopher R.
A1 - Cheung, Felix
A1 - Christopherson, Cody D.
A1 - Cillessen, Linda
A1 - Clay, Russ
A1 - Cleary, Hayley
A1 - Cloud, Mark D.
A1 - Cohn, Michael
A1 - Cohoon, Johanna
A1 - Columbus, Simon
A1 - Cordes, Andreas
A1 - Costantini, Giulio
A1 - Alvarez, Leslie D. Cramblet
A1 - Cremata, Ed
A1 - Crusius, Jan
A1 - DeCoster, Jamie
A1 - DeGaetano, Michelle A.
A1 - Della Penna, Nicolas
A1 - den Bezemer, Bobby
A1 - Deserno, Marie K.
A1 - Devitt, Olivia
A1 - Dewitte, Laura
A1 - Dobolyi, David G.
A1 - Dodson, Geneva T.
A1 - Donnellan, M. Brent
A1 - Donohue, Ryan
A1 - Dore, Rebecca A.
A1 - Dorrough, Angela
A1 - Dreber, Anna
A1 - Dugas, Michelle
A1 - Dunn, Elizabeth W.
A1 - Easey, Kayleigh
A1 - Eboigbe, Sylvia
A1 - Eggleston, Casey
A1 - Embley, Jo
A1 - Epskamp, Sacha
A1 - Errington, Timothy M.
A1 - Estel, Vivien
A1 - Farach, Frank J.
A1 - Feather, Jenelle
A1 - Fedor, Anna
A1 - Fernandez-Castilla, Belen
A1 - Fiedler, Susann
A1 - Field, James G.
A1 - Fitneva, Stanka A.
A1 - Flagan, Taru
A1 - Forest, Amanda L.
A1 - Forsell, Eskil
A1 - Foster, Joshua D.
A1 - Frank, Michael C.
A1 - Frazier, Rebecca S.
A1 - Fuchs, Heather
A1 - Gable, Philip
A1 - Galak, Jeff
A1 - Galliani, Elisa Maria
A1 - Gampa, Anup
A1 - Garcia, Sara
A1 - Gazarian, Douglas
A1 - Gilbert, Elizabeth
A1 - Giner-Sorolla, Roger
A1 - Glöckner, Andreas
A1 - Göllner, Lars
A1 - Goh, Jin X.
A1 - Goldberg, Rebecca
A1 - Goodbourn, Patrick T.
A1 - Gordon-McKeon, Shauna
A1 - Gorges, Bryan
A1 - Gorges, Jessie
A1 - Goss, Justin
A1 - Graham, Jesse
A1 - Grange, James A.
A1 - Gray, Jeremy
A1 - Hartgerink, Chris
A1 - Hartshorne, Joshua
A1 - Hasselman, Fred
A1 - Hayes, Timothy
A1 - Heikensten, Emma
A1 - Henninger, Felix
A1 - Hodsoll, John
A1 - Holubar, Taylor
A1 - Hoogendoorn, Gea
A1 - Humphries, Denise J.
A1 - Hung, Cathy O. -Y.
A1 - Immelman, Nathali
A1 - Irsik, Vanessa C.
A1 - Jahn, Georg
A1 - Jaekel, Frank
A1 - Jekel, Marc
A1 - Johannesson, Magnus
A1 - Johnson, Larissa G.
A1 - Johnson, David J.
A1 - Johnson, Kate M.
A1 - Johnston, William J.
A1 - Jonas, Kai
A1 - Joy-Gaba, Jennifer A.
A1 - Kappes, Heather Barry
A1 - Kelso, Kim
A1 - Kidwell, Mallory C.
A1 - Kim, Seung Kyung
A1 - Kirkhart, Matthew
A1 - Kleinberg, Bennett
A1 - Knezevic, Goran
A1 - Kolorz, Franziska Maria
A1 - Kossakowski, Jolanda J.
A1 - Krause, Robert Wilhelm
A1 - Krijnen, Job
A1 - Kuhlmann, Tim
A1 - Kunkels, Yoram K.
A1 - Kyc, Megan M.
A1 - Lai, Calvin K.
A1 - Laique, Aamir
A1 - Lakens, Daniel
A1 - Lane, Kristin A.
A1 - Lassetter, Bethany
A1 - Lazarevic, Ljiljana B.
A1 - LeBel, Etienne P.
A1 - Lee, Key Jung
A1 - Lee, Minha
A1 - Lemm, Kristi
A1 - Levitan, Carmel A.
A1 - Lewis, Melissa
A1 - Lin, Lin
A1 - Lin, Stephanie
A1 - Lippold, Matthias
A1 - Loureiro, Darren
A1 - Luteijn, Ilse
A1 - Mackinnon, Sean
A1 - Mainard, Heather N.
A1 - Marigold, Denise C.
A1 - Martin, Daniel P.
A1 - Martinez, Tylar
A1 - Masicampo, E. J.
A1 - Matacotta, Josh
A1 - Mathur, Maya
A1 - May, Michael
A1 - Mechin, Nicole
A1 - Mehta, Pranjal
A1 - Meixner, Johannes
A1 - Melinger, Alissa
A1 - Miller, Jeremy K.
A1 - Miller, Mallorie
A1 - Moore, Katherine
A1 - Möschl, Marcus
A1 - Motyl, Matt
A1 - Müller, Stephanie M.
A1 - Munafo, Marcus
A1 - Neijenhuijs, Koen I.
A1 - Nervi, Taylor
A1 - Nicolas, Gandalf
A1 - Nilsonne, Gustav
A1 - Nosek, Brian A.
A1 - Nuijten, Michele B.
A1 - Olsson, Catherine
A1 - Osborne, Colleen
A1 - Ostkamp, Lutz
A1 - Pavel, Misha
A1 - Penton-Voak, Ian S.
A1 - Perna, Olivia
A1 - Pernet, Cyril
A1 - Perugini, Marco
A1 - Pipitone, R. Nathan
A1 - Pitts, Michael
A1 - Plessow, Franziska
A1 - Prenoveau, Jason M.
A1 - Rahal, Rima-Maria
A1 - Ratliff, Kate A.
A1 - Reinhard, David
A1 - Renkewitz, Frank
A1 - Ricker, Ashley A.
A1 - Rigney, Anastasia
A1 - Rivers, Andrew M.
A1 - Roebke, Mark
A1 - Rutchick, Abraham M.
A1 - Ryan, Robert S.
A1 - Sahin, Onur
A1 - Saide, Anondah
A1 - Sandstrom, Gillian M.
A1 - Santos, David
A1 - Saxe, Rebecca
A1 - Schlegelmilch, Rene
A1 - Schmidt, Kathleen
A1 - Scholz, Sabine
A1 - Seibel, Larissa
A1 - Selterman, Dylan Faulkner
A1 - Shaki, Samuel
A1 - Simpson, William B.
A1 - Sinclair, H. Colleen
A1 - Skorinko, Jeanine L. M.
A1 - Slowik, Agnieszka
A1 - Snyder, Joel S.
A1 - Soderberg, Courtney
A1 - Sonnleitner, Carina
A1 - Spencer, Nick
A1 - Spies, Jeffrey R.
A1 - Steegen, Sara
A1 - Stieger, Stefan
A1 - Strohminger, Nina
A1 - Sullivan, Gavin B.
A1 - Talhelm, Thomas
A1 - Tapia, Megan
A1 - te Dorsthorst, Anniek
A1 - Thomae, Manuela
A1 - Thomas, Sarah L.
A1 - Tio, Pia
A1 - Traets, Frits
A1 - Tsang, Steve
A1 - Tuerlinckx, Francis
A1 - Turchan, Paul
A1 - Valasek, Milan
A1 - Van Aert, Robbie
A1 - van Assen, Marcel
A1 - van Bork, Riet
A1 - van de Ven, Mathijs
A1 - van den Bergh, Don
A1 - van der Hulst, Marije
A1 - van Dooren, Roel
A1 - van Doorn, Johnny
A1 - van Renswoude, Daan R.
A1 - van Rijn, Hedderik
A1 - Vanpaemel, Wolf
A1 - Echeverria, Alejandro Vasquez
A1 - Vazquez, Melissa
A1 - Velez, Natalia
A1 - Vermue, Marieke
A1 - Verschoor, Mark
A1 - Vianello, Michelangelo
A1 - Voracek, Martin
A1 - Vuu, Gina
A1 - Wagenmakers, Eric-Jan
A1 - Weerdmeester, Joanneke
A1 - Welsh, Ashlee
A1 - Westgate, Erin C.
A1 - Wissink, Joeri
A1 - Wood, Michael
A1 - Woods, Andy
A1 - Wright, Emily
A1 - Wu, Sining
A1 - Zeelenberg, Marcel
A1 - Zuni, Kellylynn
T1 - Estimating the reproducibility of psychological science
JF - Science
N2 - Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
Y1 - 2015
U6 - https://doi.org/10.1126/science.aac4716
SN - 1095-9203
SN - 0036-8075
VL - 349
IS - 6251
PB - American Assoc. for the Advancement of Science
CY - Washington
ER -
TY - JOUR
A1 - Banks, Jo Ann
A1 - Nishiyama, Tomoaki
A1 - Hasebe, Mitsuyasu
A1 - Bowman, John L.
A1 - Gribskov, Michael
A1 - dePamphilis, Claude
A1 - Albert, Victor A.
A1 - Aono, Naoki
A1 - Aoyama, Tsuyoshi
A1 - Ambrose, Barbara A.
A1 - Ashton, Neil W.
A1 - Axtell, Michael J.
A1 - Barker, Elizabeth
A1 - Barker, Michael S.
A1 - Bennetzen, Jeffrey L.
A1 - Bonawitz, Nicholas D.
A1 - Chapple, Clint
A1 - Cheng, Chaoyang
A1 - Correa, Luiz Gustavo Guedes
A1 - Dacre, Michael
A1 - DeBarry, Jeremy
A1 - Dreyer, Ingo
A1 - Elias, Marek
A1 - Engstrom, Eric M.
A1 - Estelle, Mark
A1 - Feng, Liang
A1 - Finet, Cedric
A1 - Floyd, Sandra K.
A1 - Frommer, Wolf B.
A1 - Fujita, Tomomichi
A1 - Gramzow, Lydia
A1 - Gutensohn, Michael
A1 - Harholt, Jesper
A1 - Hattori, Mitsuru
A1 - Heyl, Alexander
A1 - Hirai, Tadayoshi
A1 - Hiwatashi, Yuji
A1 - Ishikawa, Masaki
A1 - Iwata, Mineko
A1 - Karol, Kenneth G.
A1 - Koehler, Barbara
A1 - Kolukisaoglu, Uener
A1 - Kubo, Minoru
A1 - Kurata, Tetsuya
A1 - Lalonde, Sylvie
A1 - Li, Kejie
A1 - Li, Ying
A1 - Litt, Amy
A1 - Lyons, Eric
A1 - Manning, Gerard
A1 - Maruyama, Takeshi
A1 - Michael, Todd P.
A1 - Mikami, Koji
A1 - Miyazaki, Saori
A1 - Morinaga, Shin-ichi
A1 - Murata, Takashi
A1 - Müller-Röber, Bernd
A1 - Nelson, David R.
A1 - Obara, Mari
A1 - Oguri, Yasuko
A1 - Olmstead, Richard G.
A1 - Onodera, Naoko
A1 - Petersen, Bent Larsen
A1 - Pils, Birgit
A1 - Prigge, Michael
A1 - Rensing, Stefan A.
A1 - Mauricio Riano-Pachon, Diego
A1 - Roberts, Alison W.
A1 - Sato, Yoshikatsu
A1 - Scheller, Henrik Vibe
A1 - Schulz, Burkhard
A1 - Schulz, Christian
A1 - Shakirov, Eugene V.
A1 - Shibagaki, Nakako
A1 - Shinohara, Naoki
A1 - Shippen, Dorothy E.
A1 - Sorensen, Iben
A1 - Sotooka, Ryo
A1 - Sugimoto, Nagisa
A1 - Sugita, Mamoru
A1 - Sumikawa, Naomi
A1 - Tanurdzic, Milos
A1 - Theissen, Guenter
A1 - Ulvskov, Peter
A1 - Wakazuki, Sachiko
A1 - Weng, Jing-Ke
A1 - Willats, William W. G. T.
A1 - Wipf, Daniel
A1 - Wolf, Paul G.
A1 - Yang, Lixing
A1 - Zimmer, Andreas D.
A1 - Zhu, Qihui
A1 - Mitros, Therese
A1 - Hellsten, Uffe
A1 - Loque, Dominique
A1 - Otillar, Robert
A1 - Salamov, Asaf
A1 - Schmutz, Jeremy
A1 - Shapiro, Harris
A1 - Lindquist, Erika
A1 - Lucas, Susan
A1 - Rokhsar, Daniel
A1 - Grigoriev, Igor V.
T1 - The selaginella genome identifies genetic changes associated with the evolution of vascular plants
JF - Science
N2 - Vascular plants appeared similar to 410 million years ago, then diverged into several lineages of which only two survive: the euphyllophytes (ferns and seed plants) and the lycophytes. We report here the genome sequence of the lycophyte Selaginella moellendorffii (Selaginella), the first nonseed vascular plant genome reported. By comparing gene content in evolutionarily diverse taxa, we found that the transition from a gametophyte- to a sporophyte-dominated life cycle required far fewer new genes than the transition from a nonseed vascular to a flowering plant, whereas secondary metabolic genes expanded extensively and in parallel in the lycophyte and angiosperm lineages. Selaginella differs in posttranscriptional gene regulation, including small RNA regulation of repetitive elements, an absence of the trans-acting small interfering RNA pathway, and extensive RNA editing of organellar genes.
Y1 - 2011
U6 - https://doi.org/10.1126/science.1203810
SN - 0036-8075
VL - 332
IS - 6032
SP - 960
EP - 963
PB - American Assoc. for the Advancement of Science
CY - Washington
ER -
TY - JOUR
A1 - Grott, Matthias
A1 - Knollenberg, J.
A1 - Hamm, M.
A1 - Ogawa, K.
A1 - Jaumann, R.
A1 - Otto, Katharina Alexandra
A1 - Delbo, M.
A1 - Michel, P.
A1 - Biele, J.
A1 - Neumann, W.
A1 - Knapmeyer, M.
A1 - Kuehrt, E.
A1 - Senshu, H.
A1 - Okada, T.
A1 - Helbert, J.
A1 - Maturilli, A.
A1 - Müller, N.
A1 - Hagermann, A.
A1 - Sakatani, N.
A1 - Tanaka, S.
A1 - Arai, T.
A1 - Mottola, S.
A1 - Tachibana, S.
A1 - Pelivan, Ivanka
A1 - Drube, L.
A1 - Vincent, J-B
A1 - Yano, H.
A1 - Pilorget, C.
A1 - Matz, K. D.
A1 - Schmitz, N.
A1 - Koncz, A.
A1 - Schröder, S. E.
A1 - Trauthan, F.
A1 - Schlotterer, M.
A1 - Krause, C.
A1 - Ho, T-M
A1 - Moussi-Soffys, A.
T1 - Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu
JF - Nature astronomy
N2 - C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder’s thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7.
Y1 - 2020
U6 - https://doi.org/10.1038/s41550-019-0832-x
SN - 2397-3366
VL - 3
IS - 11
SP - 971
EP - 976
PB - Nature Publishing Group
CY - London
ER -
TY - JOUR
A1 - Soliveres, Santiago
A1 - Maestre, Fernando T.
A1 - Ulrich, Werner
A1 - Manning, Peter
A1 - Boch, Steffen
A1 - Bowker, Matthew A.
A1 - Prati, Daniel
A1 - Delgado-Baquerizo, Manuel
A1 - Quero, Jose L.
A1 - Schöning, Ingo
A1 - Gallardo, Antonio
A1 - Weisser, Wolfgang W.
A1 - Müller, Jörg
A1 - Socher, Stephanie A.
A1 - Garcia-Gomez, Miguel
A1 - Ochoa, Victoria
A1 - Schulze, Ernst-Detlef
A1 - Fischer, Markus
A1 - Allan, Eric
T1 - Intransitive competition is widespread in plant communities and maintains their species richness
JF - Ecology letters
N2 - Intransitive competition networks, those in which there is no single best competitor, may ensure species coexistence. However, their frequency and importance in maintaining diversity in real-world ecosystems remain unclear. We used two large data sets from drylands and agricultural grasslands to assess: (1) the generality of intransitive competition, (2) intransitivity-richness relationships and (3) effects of two major drivers of biodiversity loss (aridity and land-use intensification) on intransitivity and species richness. Intransitive competition occurred in >65% of sites and was associated with higher species richness. Intransitivity increased with aridity, partly buffering its negative effects on diversity, but was decreased by intensive land use, enhancing its negative effects on diversity. These contrasting responses likely arise because intransitivity is promoted by temporal heterogeneity, which is enhanced by aridity but may decline with land-use intensity. We show that intransitivity is widespread in nature and increases diversity, but it can be lost with environmental homogenisation.
KW - Aridity
KW - biodiversity
KW - coexistence
KW - drylands
KW - land use
KW - mesic grasslands
KW - rock-paper-scissors game
Y1 - 2015
U6 - https://doi.org/10.1111/ele.12456
SN - 1461-023X
SN - 1461-0248
VL - 18
IS - 8
SP - 790
EP - 798
PB - Wiley-Blackwell
CY - Hoboken
ER -
TY - JOUR
A1 - Read, Betsy A.
A1 - Kegel, Jessica
A1 - Klute, Mary J.
A1 - Kuo, Alan
A1 - Lefebvre, Stephane C.
A1 - Maumus, Florian
A1 - Mayer, Christoph
A1 - Miller, John
A1 - Monier, Adam
A1 - Salamov, Asaf
A1 - Young, Jeremy
A1 - Aguilar, Maria
A1 - Claverie, Jean-Michel
A1 - Frickenhaus, Stephan
A1 - Gonzalez, Karina
A1 - Herman, Emily K.
A1 - Lin, Yao-Cheng
A1 - Napier, Johnathan
A1 - Ogata, Hiroyuki
A1 - Sarno, Analissa F.
A1 - Shmutz, Jeremy
A1 - Schroeder, Declan
A1 - de Vargas, Colomban
A1 - Verret, Frederic
A1 - von Dassow, Peter
A1 - Valentin, Klaus
A1 - Van de Peer, Yves
A1 - Wheeler, Glen
A1 - Dacks, Joel B.
A1 - Delwiche, Charles F.
A1 - Dyhrman, Sonya T.
A1 - Glöckner, Gernot
A1 - John, Uwe
A1 - Richards, Thomas
A1 - Worden, Alexandra Z.
A1 - Zhang, Xiaoyu
A1 - Grigoriev, Igor V.
A1 - Allen, Andrew E.
A1 - Bidle, Kay
A1 - Borodovsky, M.
A1 - Bowler, C.
A1 - Brownlee, Colin
A1 - Cock, J. Mark
A1 - Elias, Marek
A1 - Gladyshev, Vadim N.
A1 - Groth, Marco
A1 - Guda, Chittibabu
A1 - Hadaegh, Ahmad
A1 - Iglesias-Rodriguez, Maria Debora
A1 - Jenkins, J.
A1 - Jones, Bethan M.
A1 - Lawson, Tracy
A1 - Leese, Florian
A1 - Lindquist, Erika
A1 - Lobanov, Alexei
A1 - Lomsadze, Alexandre
A1 - Malik, Shehre-Banoo
A1 - Marsh, Mary E.
A1 - Mackinder, Luke
A1 - Mock, Thomas
A1 - Müller-Röber, Bernd
A1 - Pagarete, Antonio
A1 - Parker, Micaela
A1 - Probert, Ian
A1 - Quesneville, Hadi
A1 - Raines, Christine
A1 - Rensing, Stefan A.
A1 - Riano-Pachon, Diego Mauricio
A1 - Richier, Sophie
A1 - Rokitta, Sebastian
A1 - Shiraiwa, Yoshihiro
A1 - Soanes, Darren M.
A1 - van der Giezen, Mark
A1 - Wahlund, Thomas M.
A1 - Williams, Bryony
A1 - Wilson, Willie
A1 - Wolfe, Gordon
A1 - Wurch, Louie L.
T1 - Pan genome of the phytoplankton Emiliania underpins its global distribution
JF - Nature : the international weekly journal of science
N2 - Coccolithophores have influenced the global climate for over 200 million years(1). These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems(2). They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering them visible from space(3). Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean(4). Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate that E. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions.
Y1 - 2013
U6 - https://doi.org/10.1038/nature12221
SN - 0028-0836
SN - 1476-4687
VL - 499
IS - 7457
SP - 209
EP - 213
PB - Nature Publ. Group
CY - London
ER -
TY - JOUR
A1 - del Valle, Maria Victoria
A1 - Müller, A. L.
A1 - Romero, G. E.
T1 - High-energy radiation from collisions of high-velocity clouds and the Galactic disc
JF - Monthly notices of the Royal Astronomical Society
N2 - High-velocity clouds (HVCs) are interstellar clouds of atomic hydrogen that do not follow normal Galactic rotation and have velocities of a several hundred kilometres per second. A considerable number of these clouds are falling down towards the Galactic disc. HVCs form large and massive complexes, so if they collide with the disc a great amount of energy would be released into the interstellar medium. The cloud-disc interaction produces two shocks: one propagates through the cloud and the other through the disc. The properties of these shocks depend mainly on the cloud velocity and the disc-cloud density ratio. In this work, we study the conditions necessary for these shocks to accelerate particles by diffusive shock acceleration and we study the non-thermal radiation that is produced. We analyse particle acceleration in both the cloud and disc shocks. Solving a time-dependent two-dimensional transport equation for both relativistic electrons and protons, we obtain particle distributions and non-thermal spectral energy distributions. In a shocked cloud, significant synchrotron radio emission is produced along with soft gamma rays. In the case of acceleration in the shocked disc, the non-thermal radiation is stronger; the gamma rays, of leptonic origin, might be detectable with current instruments. A large number of protons are injected into the Galactic interstellar medium, and locally exceed the cosmic ray background. We conclude that under adequate conditions the contribution from HVC-disc collisions to the galactic population of relativistic particles and the associated extended non-thermal radiation might be important.
KW - radiation mechanisms: non-thermal
KW - ISM: clouds
KW - cosmic rays
Y1 - 2018
U6 - https://doi.org/10.1093/mnras/stx2984
SN - 0035-8711
SN - 1365-2966
VL - 475
IS - 4
SP - 4298
EP - 4308
PB - Oxford Univ. Press
CY - Oxford
ER -
TY - JOUR
A1 - Meyer, S.
A1 - Raber, G.
A1 - Ebert, Franziska
A1 - Leffers, L.
A1 - Müller, Sandra Marie
A1 - Taleshi, M. S.
A1 - Francesconi, Kevin A.
A1 - Schwerdtle, Tanja
T1 - In vitro toxicological characterisation of arsenic-containing fatty acids and three of their metabolites
JF - Toxicology research
N2 - Arsenic-containing fatty acids are a group of fat-soluble arsenic species (arsenolipids) which are present in marine fish and other seafood. Recently, it has been shown that arsenic-containing hydrocarbons, another group of arsenolipids, exert toxicity in similar concentrations comparable to arsenite although the toxic modes of action differ. Hence, a risk assessment of arsenolipids is urgently needed. In this study the cellular toxicity of a saturated (AsFA 362) and an unsaturated (AsFA 388) arsenic-containing fatty acid and three of their proposed metabolites (DMAV, DMAPr and thio-DMAPr) were investigated in human liver cells (HepG2). Even though both arsenic-containing fatty acids were less toxic as compared to arsenic-containing hydrocarbons and arsenite, significant effects were observable at μM concentrations. DMAV causes effects in a similar concentration range and it could be seen that it is metabolised to its highly toxic thio analogue thio-DMAV in HepG2 cells. Nevertheless, DMAPr and thio-DMAPr did not exert any cytotoxicity. In summary, our data indicate that risks to human health related to the presence of arsenic-containing fatty acids in marine food cannot be excluded. This stresses the need for a full in vitro and in vivo toxicological characterisation of these arsenolipids.
Y1 - 2015
U6 - https://doi.org/10.1039/c5tx00122f
SN - 2045-4538
VL - 5
IS - 4
SP - 1289
EP - 1296
PB - Royal Society of Chemistry
CY - Cambridge
ER -
TY - GEN
A1 - Meyer, S.
A1 - Raber, G.
A1 - Ebert, Franziska
A1 - Leffers, L.
A1 - Müller, Sandra Marie
A1 - Taleshi, M. S.
A1 - Francesconi, Kevin A.
A1 - Schwerdtle, Tanja
T1 - In vitro toxicological characterisation of arsenic-containing fatty acids and three of their metabolites
N2 - Arsenic-containing fatty acids are a group of fat-soluble arsenic species (arsenolipids) which are present in marine fish and other seafood. Recently, it has been shown that arsenic-containing hydrocarbons, another group of arsenolipids, exert toxicity in similar concentrations comparable to arsenite although the toxic modes of action differ. Hence, a risk assessment of arsenolipids is urgently needed. In this study the cellular toxicity of a saturated (AsFA 362) and an unsaturated (AsFA 388) arsenic-containing fatty acid and three of their proposed metabolites (DMAV, DMAPr and thio-DMAPr) were investigated in human liver cells (HepG2). Even though both arsenic-containing fatty acids were less toxic as compared to arsenic-containing hydrocarbons and arsenite, significant effects were observable at μM concentrations. DMAV causes effects in a similar concentration range and it could be seen that it is metabolised to its highly toxic thio analogue thio-DMAV in HepG2 cells. Nevertheless, DMAPr and thio-DMAPr did not exert any cytotoxicity. In summary, our data indicate that risks to human health related to the presence of arsenic-containing fatty acids in marine food cannot be excluded. This stresses the need for a full in vitro and in vivo toxicological characterisation of these arsenolipids.
T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 199
Y1 - 2015
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-82008
ER -
TY - JOUR
A1 - Pfestorf, H.
A1 - Weiss, L.
A1 - Müller, J.
A1 - Boch, Steffen
A1 - Socher, S. A.
A1 - Prati, Daniel
A1 - Schöning, Ingo
A1 - Weisser, W.
A1 - Fischer, M.
A1 - Jeltsch, Florian
T1 - Community mean traits as additional indicators to monitor effects of land-use intensity On grassland plant diversity
JF - Perspectives in plant ecology, evolution and systematics
N2 - Semi-natural grasslands, biodiversity hotspots in Central-Europe, suffer from the cessation of traditional land-use. Amount and intensity of these changes challenge current monitoring frameworks typically based on classic indicators such as selected target species or diversity indices. Indicators based on plant functional traits provide an interesting extension since they reflect ecological strategies at individual and ecological processes at community levels. They typically show convergent responses to gradients of land-use intensity over scales and regions, are more directly related to environmental drivers than diversity components themselves and enable detecting directional changes in whole community dynamics. However, probably due to their labor- and cost intensive assessment in the field, they have been rarely applied as indicators so far.
Here we suggest overcoming these limitations by calculating indicators with plant traits derived from online accessible databases. Aiming to provide a minimal trait set to monitor effects of land-use intensification on plant diversity we investigated relationships between 12 community mean traits, 2 diversity indices and 6 predictors of land-use intensity within grassland communities of 3 different regions in Germany (part of the German 'Biodiversity Exploratory' research network). By standardization of traits and diversity measures, use of null models and linear mixed models we confirmed (i) strong links between functional community composition and plant diversity, (ii) that traits are closely related to land-use intensity, and (iii) that functional indicators are equally, or even more sensitive to land-use intensity than traditional diversity indices. The deduced trait set consisted of 5 traits, i.e., specific leaf area (SLA), leaf dry matter content (LDMC), seed release height, leaf distribution, and onset of flowering. These database derived traits enable the early detection of changes in community structure indicative for future diversity loss. As an addition to current monitoring measures they allow to better link environmental drivers to processes controlling community dynamics.
KW - Biodiversity Exploratories
KW - Biological conservation
KW - (Semi-natural) Grasslands
KW - Plant functional traits
KW - Indicators
KW - Land-use intensity
Y1 - 2013
U6 - https://doi.org/10.1016/j.ppees.2012.10.003
SN - 1433-8319
VL - 15
IS - 1
SP - 1
EP - 11
PB - Elsevier
CY - Jena
ER -
TY - JOUR
A1 - Gomez-Merino, Fernando Carlos
A1 - Arana-Ceballos, Fernando Alberto
A1 - Trejo-Tellez, L. I.
A1 - Skirycz, Aleksandra
A1 - Brearley, C. A.
A1 - Dormann, P.
A1 - Müller-Röber, Bernd
T1 - Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases (DGKs), displays unique biochemical features and saturates at low substrate concentration : the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro and alters plant growth and development
N2 - Diacylglycerol kinase (DGK) regulates the level of the second messenger diacylglycerol and produces phosphatidic acid (PA), another signaling molecule. The Arabidopsis thaliana genome encodes seven putative diacylglycerol kinase isozymes (named AtDGK1 to -7), structurally falling into three major clusters. So far, enzymatic activity has not been reported for any plant Cluster II DGK. Here, we demonstrate that a representative of this cluster, AtDGK7, is biochemically active when expressed as a recombinant protein in Escherichia coli. AtDGK7, encoded by gene locus At4g30340, contains 374 amino acids with an apparent molecular mass of 41.2 kDa. AtDGK7 harbors an N-terminal catalytic domain, but in contrast to various characterized DGKs (including AtDGK2), it lacks a cysteine-rich domain at its N terminus, and, importantly, its C-terminal DGK accessory domain is incomplete. Recombinant AtDGK7 expressed in E. coli exhibits Michaelis-Menten type kinetics with 1,2-dioleoyl-sn-glycerol as substrate. AtDGK7 activity was affected by pH, detergents, and the DGK inhibitor R59022. We demonstrate that both AtDGK2 and AtDGK7 phosphorylate diacylglycerol molecular species that are typically found in plants, indicating that both enzymes convert physiologically relevant substrates. AtDGK7 is expressed throughout the Arabidopsis plant, but expression is strongest in flowers and young seedlings. Expression of AtDGK2 is transiently induced by wounding. R59022 at similar to 80 mu M inhibits root elongation and lateral root formation and reduces plant growth, indicating that DGKs play an important role in plant development
Y1 - 2005
SN - 0021-9258
ER -
TY - JOUR
A1 - Nguyen, Hung M.
A1 - Schippers, Jos H. M.
A1 - Goni-Ramos, Oscar
A1 - Christoph, Mathias P.
A1 - Dortay, Hakan
A1 - van der Hoorn, Renier A. L.
A1 - Müller-Röber, Bernd
T1 - An upstream regulator of the 26S proteasome modulates organ size in Arabidopsis thaliana
JF - The plant journal
N2 - In both animal and plant kingdoms, body size is a fundamental but still poorly understood attribute of biological systems. Here we report that the Arabidopsis NAC transcription factor Regulator of Proteasomal Gene Expression' (RPX) controls leaf size by positively modulating proteasome activity. We further show that the cis-element recognized by RPX is evolutionarily conserved between higher plant species. Upon over-expression of RPX, plants exhibit reduced growth, which may be reversed by a low concentration of the pharmacological proteasome inhibitor MG132. These data suggest that the rate of protein turnover during growth is a critical parameter for determining final organ size.
KW - Arabidopsis thaliana
KW - organ size
KW - evolution
KW - leaf development
KW - proteasome
KW - gene regulatory network
Y1 - 2013
U6 - https://doi.org/10.1111/tpj.12097
SN - 0960-7412
VL - 74
IS - 1
SP - 25
EP - 36
PB - Wiley-Blackwell
CY - Hoboken
ER -
TY - GEN
A1 - Müller-Schöll, A.
A1 - Klopp-Schulze, Lena
A1 - Huisinga, Wilhelm
A1 - Jörger, M.
A1 - Neven, P.
A1 - Koolen, S. L.
A1 - Mathijssen, R. H. J.
A1 - Schmidt, S.
A1 - Kloft, Charlotte
T1 - Patient-tailored tamoxifen dosing based on an increased quantitative understanding of its complex pharmacokinetics: A novel integrative modelling approach
T2 - Annals of Oncology
Y1 - 2019
SN - 0923-7534
SN - 1569-8041
VL - 30
PB - Oxford Univ. Press
CY - Oxford
ER -