TY - JOUR A1 - Voigt-Zimmermann, Susanne A1 - Stier, Karl-Heinz A1 - Lascheit, Thomas A1 - Kruse, Stephanie A. A1 - Blickensdorff, Maria A1 - Förster, Theresa A1 - Schumacher, Rebecca A1 - Burchert, Frank A1 - Ablinger, Irene A1 - Förster, Christine A1 - Wahl, Michael A1 - Schirmacher, Irene A1 - Ostermann, Frank A1 - Welke, Lisa-Marie A1 - Frank, Ulrike A1 - Zakariás, Lilla A1 - Salis, Christos A1 - Wartenburger, Isabell A1 - Krug, Ragna A1 - Stübner, Hanna A1 - Hoffmann, Sophie A1 - Heide, Judith ED - Fritzsche, Tom ED - Yetim, Özlem ED - Otto, Constanze ED - Adelt, Anne T1 - Spektrum Patholinguistik Band 11. Schwerpunktthema: Gut gestimmt: Diagnostik und Therapie bei Dysphonie N2 - Das 11. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Gut gestimmt: Diagnostik und Therapie bei Dysphonie« fand am 18.11.2017 in Potsdam statt. Das Herbsttreffen wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. Der vorliegende Tagungsband beinhaltet die Hauptvorträge zum Schwerpunktthema sowie Beiträge zu den Kurzvorträgen »Spektrum Patholinguistik« und der Posterpräsentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis. N2 - The Eleventh Autumn Meeting Patholinguistics (Herbsttreffen Patholinguistik) with its main topic »Well tuned: Diagnostics and therapy in dysphonia« took place in Potsdam on November 18 2017. This annual meeting has been organised since 2007 by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl). The present proceedings contain the keynote talks on the main topic as well as contributions from the short talks in the section »Spectrum Patholinguistics« and from the poster session covering a broad range of areas in speech/language therapy research and practice. T3 - Spektrum Patholinguistik - 11 KW - Patholinguistik KW - Sprachtherapie KW - Stimmtherapie KW - Stimmstörung KW - Dysphonie KW - patholinguistics KW - speech/language therapy KW - voice therapy KW - dysphonia Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-418574 SN - 978-3-86956-448-7 SN - 1866-9085 SN - 1866-9433 IS - 11 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Mehnert, Jan A1 - Akhrif, Atae A1 - Telkemeyer, Silke A1 - Rossi, Sonja A1 - Schmitz, Christoph H. A1 - Steinbrink, Jens A1 - Wartenburger, Isabell A1 - Obrig, Hellmuth A1 - Neufang, Susanne T1 - Developmental changes in brain activation and functional connectivity during response inhibition in the early childhood brain JF - Brain and development : official journal of the Japanese Society of Child Neurology N2 - Response inhibition is an attention function which develops relatively early during childhood. Behavioral data suggest that by the age of 3, children master the basic task requirements for the assessment of response inhibition but performance improves substantially until the age of 7. The neuronal mechanisms underlying these developmental processes, however, are not well understood. In this study, we examined brain activation patterns and behavioral performance of children aged between 4 and 6 years compared to adults by applying a go/no-go paradigm during near-infrared spectroscopy (NIRS) brain imaging. We furthermore applied task-independent functional connectivity measures to the imaging data to identify maturation of intrinsic neural functional networks. We found a significant group x condition related interaction in terms of inhibition-related reduced right fronto-parietal activation in children compared to adults. In contrast, motor-related activation did not differ between age groups. Functional connectivity analysis revealed that in the children's group, short-range coherence within frontal areas was stronger, and long-range coherence between frontal and parietal areas was weaker, compared to adults. Our findings show that in children aged from 4 to 6 years fronto-parietal brain maturation plays a crucial part in the cognitive development of response inhibition. KW - Optical tomography KW - NIRS KW - Response inhibition KW - Functional connectivity KW - Development KW - Early childhood Y1 - 2013 U6 - https://doi.org/10.1016/j.braindev.2012.11.006 SN - 0387-7604 SN - 1872-7131 VL - 35 IS - 10 SP - 894 EP - 904 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Telkemeyer, Silke A1 - Rossi, Sonja A1 - Koch, Stefan P. A1 - Nierhaus, Till A1 - Steinbrink, Jens A1 - Poeppel, David A1 - Obrig, Hellmuth A1 - Wartenburger, Isabell T1 - Sensitivity of newborn auditory cortex to the temporal structure of sounds N2 - Understanding the rapidly developing building blocks of speech perception in infancy requires a close look at the auditory prerequisites for speech sound processing. Pioneering studies have demonstrated that hemispheric specializations for language processing are already present in early infancy. However, whether these computational asymmetries can be considered a function of linguistic attributes or a consequence of basic temporal signal properties is under debate. Several studies in adults link hemispheric specialization for certain aspects of speech perception to an asymmetry in cortical tuning and reveal that the auditory cortices are differentially sensitive to spectrotemporal features of speech. Applying concurrent electrophysiological (EEG) and hemodynamic (near-infrared spectroscopy) recording to newborn infants listening to temporally structured nonspeech signals, we provide evidence that newborns process nonlinguistic acoustic stimuli that share critical temporal features with language in a differential manner. The newborn brain preferentially processes temporal modulations especially relevant for phoneme perception. In line with multi-time-resolution conceptions, modulations on the time scale of phonemes elicit strong bilateral cortical responses. Our data furthermore suggest that responses to slow acoustic modulations are lateralized to the right hemisphere. That is, the newborn auditory cortex is sensitive to the temporal structure of the auditory input and shows an emerging tendency for functional asymmetry. Hence, our findings support the hypothesis that development of speech perception is linked to basic capacities in auditory processing. From birth, the brain is tuned to critical temporal properties of linguistic signals to facilitate one of the major needs of humans: to communicate. Y1 - 2009 UR - http://www.jneurosci.org/ U6 - https://doi.org/10.1523/Jneurosci.1246-09.2009 SN - 0270-6474 ER - TY - JOUR A1 - Passow, Susanne A1 - Müller, Maike A1 - Westerhausen, Rene A1 - Hugdahl, Kenneth A1 - Wartenburger, Isabell A1 - Heekeren, Hauke R. A1 - Lindenberger, Ulman A1 - Li, Shu-Chen T1 - Development of attentional control of verbal auditory perception from middle to late childhood - comparisons to healthy aging JF - Developmental psychology N2 - Multitalker situations confront listeners with a plethora of competing auditory inputs, and hence require selective attention to relevant information, especially when the perceptual saliency of distracting inputs is high. This study augmented the classical forced-attention dichotic listening paradigm by adding an interaural intensity manipulation to investigate developmental differences in the interplay between perceptual saliency and attentional control during auditory processing between early and middle childhood. We found that older children were able to flexibly focus on instructed auditory inputs from either the right or the left ear, overcoming the effects of perceptual saliency. In contrast, younger children implemented their attentional focus less efficiently. Direct comparisons of the present data with data from a recently published study of younger and older adults from our group suggest that younger children and older adults show similar levels of performance. Critically, follow-up comparisons revealed that younger children's performance restrictions reflect difficulties in attentional control only, whereas older adults' performance deficits also reflect an exaggerated reliance on perceptual saliency. We conclude that auditory attentional control improves considerably from middle to late childhood and that auditory attention deficits in healthy aging cannot be reduced to a simple reversal of child developmental improvements. KW - child development KW - attentional control KW - auditory perception KW - aging KW - dichotic listening Y1 - 2013 U6 - https://doi.org/10.1037/a0031207 SN - 0012-1649 VL - 49 IS - 10 SP - 1982 EP - 1993 PB - American Psychological Association CY - Washington ER - TY - JOUR A1 - Wartenburger, Isabell A1 - Kühn, Esther A1 - Sassenberg, Uta A1 - Foth, Manja A1 - Franz, Elisabeth A. A1 - van der Meer, Elke T1 - On the relationship between fluid intelligence, gesture production, and brain structure N2 - Individuals scoring high in fluid intelligence tasks generally perform very efficiently in problem solving tasks and analogical reasoning tasks presumably because they are able to select the task-relevant information very quickly and focus on a limited set of task-relevant cognitive operations. Moreover, individuals with high fluid intelligence produce more representational hand and arm gestures when describing a geometric analogy task than individuals with average fluid intelligence. No study has yet addressed the relationship between intelligence, gesture production, and brain structure, to our knowledge. That was the purpose of our study. To characterize the relation between intelligence, gesture production, and brain structure we assessed the frequency of representational gestures and cortical thickness values in a group of adolescents differing in fluid intelligence. Individuals scoring high in fluid intelligence showed higher accuracy in the geometric analogy task and produced more representational gestures (in particular more movement gestures) when explaining how they solved the task and showed larger cortical thickness values in some regions in the left hemisphere (namely the pars opercularis, superior frontal, and temporal cortex) than individuals with average fluid intelligence. Moreover, the left pars opercularis (a part of Broca's area) and left transverse temporal cortex showed larger cortical thickness values in participants who produced representational and in particular movement gestures compared to those who did not. Our results thus indicate that cortical thickness of those brain regions is related to both high fluid intelligence and the production of gestures. Results are discussed in the gestures-as-simulated-action framework that states that gestures result from simulated perception and simulated action that underlie embodied language and mental imagery. Y1 - 2010 UR - http://www.sciencedirect.com/science/journal/01602896 U6 - https://doi.org/10.1016/j.intell.2009.11.001 SN - 0160-2896 ER - TY - JOUR A1 - Wartenburger, Isabell A1 - Heekeren, Hauke R. A1 - Preusse, Franziska A1 - Kramer, Jürg A1 - van der Meer, Elke T1 - Cerebral correlates of analogical processing and their modulation by training N2 - There is increasing interest ill understanding the neural systems that mediate analogical thinking, which is essential for learning and fluid intelligence. The aim of the present study was to shed light on the cerebral correlates of geometric analogical processing and on training-induced changes at the behavioral and brain level. In healthy participants a bilateral fronto-parietal network was engaged in processing geometric analogies and showed greater blood oxygenation dependent (BOLD) signals as resource demands increased. This network, as well as fusiform and subcortical brain regions, additionally showed training-induced decreases in the BOLD signal over time. The general finding that brain regions were modulated by the amount of resources demanded by the task, and/or by the reduction of allocated resources due to short term training, reflects increased efficiency - in terms of more focal and more specialized brain activation - to more economically process the geometric analogies. Our data indicate a rapid adaptation of the cognitive system which is efficiently modulated by short term training based on a positive correlation of resource demands and brain activation. Y1 - 2009 UR - http://www.sciencedirect.com/science/journal/10538119 U6 - https://doi.org/10.1016/j.neuroimage.2009.06.025 SN - 1053-8119 ER - TY - JOUR A1 - Prehn, Kristin A1 - Wartenburger, Isabell A1 - Mériau, Katja A1 - Scheibe, Christina A1 - Goodenough, Oliver R. A1 - Villringer, Arno A1 - van der Meer, Elke A1 - Heekeren, Hauke R. T1 - Individual differences in moral judgment competence influence neural correlates of socio-normative judgments Y1 - 2008 UR - http://scan.oxfordjournals.org/content/by/year SN - 1749-5016 ER - TY - JOUR A1 - van der Meer, Elke A1 - Beyer, Reinhard A1 - Horn, Judith A1 - Foth, Manja A1 - Bornemann, Boris A1 - Ries, Jan A1 - Kramer, Jürg A1 - Warmuth, Elke A1 - Heekeren, Hauke R. A1 - Wartenburger, Isabell T1 - Resource allocation and fluid intelligence ; insights from pupillometry Y1 - 2010 UR - http://www3.interscience.wiley.com/journal/118485671/home?CRETRY=1&SRETRY=0 SN - 0048-5772 ER - TY - JOUR A1 - Cannestra, Andrew F. A1 - Wartenburger, Isabell A1 - Obrig, Hellmuth A1 - Villringer, Arno A1 - Toga, Arthur W. T1 - Functional assessment of Broca's area using near infrared spectroscopy in humans Y1 - 2003 UR - http://gateway.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=toc&SEARCH=00001756-000000000- 00000.kc&LINKTYPE=asBody&LINKPOS=1&D=yrovft SN - 0959-4965 ER - TY - JOUR A1 - Scheibe, Christina A1 - Wartenburger, Isabell A1 - Wüstenberg, Torsten A1 - Kathmann, Norbert A1 - Villringer, Arno A1 - Heekeren, Hauke R. T1 - Neural correlates of the interaction between transient and sustained processes : a mixed blocked/event-related fMRI study Y1 - 2006 UR - http://www3.interscience.wiley.com/journal/38751/home SN - 1065-9471 ER - TY - JOUR A1 - Rossi, Sonja A1 - Jürgenson, Ina B. A1 - Hanulikova, Adriana A1 - Telkemeyer, Silke A1 - Wartenburger, Isabell A1 - Obrig, Hellmuth T1 - Implicit processing of phonotactic cues evidence from electrophysiological and vascular responses JF - Journal of cognitive neuroscience N2 - Spoken word recognition is achieved via competition between activated lexical candidates that match the incoming speech input. The competition is modulated by prelexical cues that are important for segmenting the auditory speech stream into linguistic units. One such prelexical cue that listeners rely on in spoken word recognition is phonotactics. Phonotactics defines possible combinations of phonemes within syllables or words in a given language. The present study aimed at investigating both temporal and topographical aspects of the neuronal correlates of phonotactic processing by simultaneously applying ERPs and functional near-infrared spectroscopy (fNIRS). Pseudowords, either phonotactically legal or illegal with respect to the participants' native language, were acoustically presented to passively listening adult native German speakers. ERPs showed a larger N400 effect for phonotactically legal compared to illegal pseudowords, suggesting stronger lexical activation mechanisms in phonotactically legal material. fNIRS revealed a left hemispheric network including fronto-temporal regions with greater response to phonotactically legal pseudowords than to illegal pseudowords. This confirms earlier hypotheses on a left hemispheric dominance of phonotactic processing most likely due to the fact that phonotactics is related to phonological processing and represents a segmental feature of language comprehension. These segmental linguistic properties of a stimulus are predominantly processed in the left hemisphere. Thus, our study provides first insights into temporal and topographical characteristics of phonotactic processing mechanisms in a passive listening task. Differential brain responses between known and unknown phonotactic rules thus supply evidence for an implicit use of phonotactic cues to guide lexical activation mechanisms. Y1 - 2011 U6 - https://doi.org/10.1162/jocn.2010.21547 SN - 0898-929X VL - 23 IS - 7 SP - 1752 EP - 1764 PB - MIT Press CY - Cambridge ER - TY - JOUR A1 - Preusse, Franziska A1 - van der Meer, Elke A1 - Deshpande, Gopikrishna A1 - Krüger, Frank A1 - Wartenburger, Isabell T1 - Fluid intelligence allows flexible recruitment of the parieto-frontal network in analogical reasoning JF - Frontiers in human neuroscienc N2 - Fluid intelligence is the ability to think flexibly and to understand abstract relations. People with high fluid intelligence (hi-fluIQ) perform better in analogical reasoning tasks than people with average fluid intelligence (ave-fluIQ). Although previous neuroimaging studies reported involvement of parietal and frontal brain regions in geometric analogical reasoning (which is a prototypical task for fluid intelligence), however, neuroimaging findings on geometric analogical reasoning in hi-fluIQ are sparse. Furthermore, evidence on the relation between brain activation and intelligence while solving cognitive tasks is contradictory. The present study was designed to elucidate the cerebral correlates of geometric analogical reasoning in a sample of hi-fluIQ and ave-fluIQ high school students. We employed a geometric analogical reasoning task with graded levels of task difficulty and confirmed the involvement of the parieto-frontal network in solving this task. In addition to characterizing the brain regions involved in geometric analogical reasoning in hi-fluIQ and ave-fluIQ, we found that blood oxygenation level dependency (BOLD) signal changes were greater for hi-fluIQ than for ave-fluIQ in parietal brain regions. However, ave-fluIQ showed greater BOLD signal changes in the anterior cingulate cortex and medial frontal gyrus than hi-fluIQ. Thus, we showed that a similar network of brain regions is involved in geometric analogical reasoning in both groups. Interestingly, the relation between brain activation and intelligence is not mono-directional, but rather, it is specific for each brain region. The negative brain activation-intelligence relationship in frontal brain regions in hi-fluIQ goes along with a better behavioral performance and reflects a lower demand for executive monitoring compared to ave-fluIQ individuals. In conclusion, our data indicate that flexibly modulating the extent of regional cerebral activity is characteristic for fluid intelligence. KW - high fluid intelligence KW - geometric analogical reasoning KW - task difficulty KW - functional magnetic resonance imaging KW - parieto-frontal network Y1 - 2011 U6 - https://doi.org/10.3389/fnhum.2011.00022 SN - 1662-5161 VL - 5 IS - 3 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Wellmann, Caroline A1 - Holzgrefe-Lang, Julia A1 - Truckenbrodt, Hubert A1 - Wartenburger, Isabell A1 - Höhle, Barbara T1 - How each prosodic boundary cue matters evidence from German infants JF - Frontiers in psychology N2 - Previous studies have revealed that infants aged 6-10 months are able to use the acoustic correlates of major prosodic boundaries, that is, pitch change, preboundary lengthening, and pause, for the segmentation of the continuous speech signal. Moreover, investigations with American-English- and Dutch-learning infants suggest that processing prosodic boundary markings involves a weighting of these cues. This weighting seems to develop with increasing exposure to the native language and to underlie crosslinguistic variation. In the following, we report the results of four experiments using the headturn preference procedure to explore the perception of prosodic boundary cues in German infants. We presented 8-month-old infants with a sequence of names in two different prosodic groupings, with or without boundary markers. Infants discriminated both sequences when the boundary was marked by all three cues (Experiment 1) and when it was marked by a pitch change and preboundary lengthening in combination (Experiment 2). The presence of a pitch change (Experiment 3) or preboundary lengthening (Experiment 4) as single cues did not lead to a successful discrimination. Our results indicate that pause is not a necessary cue for German infants. Pitch change and preboundary lengthening in combination, but not as single cues, are sufficient. Hence, by 8 months infants only rely on a convergence of boundary markers. Comparisons with adults' performance on the same stimulus materials suggest that the pattern observed with the 8-month-olds is already consistent with that of adults. We discuss our findings with respect to crosslinguistic variation and the development of a language-specific prosodic cue weighting. KW - infants KW - language acquisition KW - speech perception KW - prosodic bootstrapping KW - prosodic boundary cues KW - cue weighting KW - intonation phrase boundary KW - headturn preference procedure Y1 - 2012 U6 - https://doi.org/10.3389/fpsyg.2012.00580 SN - 1664-1078 VL - 3 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Rossi, Sonja A1 - Telkemeyer, Silke A1 - Wartenburger, Isabell A1 - Obrig, Hellmuth T1 - Shedding light on words and sentences near-infrared spectroscopy in language research JF - Brain & language : a journal of the neurobiology of language N2 - Investigating the neuronal network underlying language processing may contribute to a better understanding of how the brain masters this complex cognitive function with surprising ease and how language is acquired at a fast pace in infancy. Modern neuroimaging methods permit to visualize the evolvement and the function of the language network. The present paper focuses on a specific methodology, functional near-infrared spectroscopy (fNIRS), providing an overview over studies on auditory language processing and acquisition. The methodology detects oxygenation changes elicited by functional activation of the cerebral cortex. The main advantages for research on auditory language processing and its development during infancy are an undemanding application, the lack of instrumental noise, and its potential to simultaneously register electrophysiological responses. Also it constitutes an innovative approach for studying developmental issues in infants and children. The review will focus on studies on word and sentence processing including research in infants and adults. KW - Language KW - Language acquisition KW - Word processing KW - Sentence processing KW - Lateralization KW - Optical imaging (OI) KW - Near-infrared spectroscopy (NIRS) KW - Electroencephalography (EEG) Y1 - 2012 U6 - https://doi.org/10.1016/j.bandl.2011.03.008 SN - 0093-934X VL - 121 IS - 2 SP - 152 EP - 163 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Holzgrefe-Lang, Julia A1 - Wellmann, Caroline A1 - Petrone, Caterina A1 - Truckenbrodt, Hubert A1 - Höhle, Barbara A1 - Wartenburger, Isabell T1 - Brain response to prosodic boundary cues depends on boundary position JF - Frontiers in psychology N2 - Prosodic information is crucial for spoken language comprehension and especially for syntactic parsing, because prosodic cues guide the hearer's syntactic analysis. The time course and mechanisms of this interplay of prosody and syntax are not yet well-understood. In particular, there is an ongoing debate whether local prosodic cues are taken into account automatically or whether they are processed in relation to the global prosodic context in which they appear. The present study explores whether the perception of a prosodic boundary is affected by its position within an utterance. In an event-related potential (PRP) study we tested if the brain response evoked by the prosodic boundary differs when the boundary occurs early in a list of three names connected by conjunctions (i.e., after the first name) as compared to later in the utterance (i.e., after the second name). A closure positive shift (CPS)-marking the processing of a prosodic phrase boundary-was elicited for stimuli with a late boundary, but not for stimuli with an early boundary. This result is further evidence for an immediate integration of prosodic information into the parsing of an utterance. In addition, it shows that the processing of prosodic boundary cues depends on the previously processed information from the preceding prosodic context. KW - prosodic boundaries KW - event-related potentials KW - closure positive shift KW - speech perception KW - prosody Y1 - 2013 U6 - https://doi.org/10.3389/fpsyg.2013.00421 SN - 1664-1078 VL - 4 IS - 28 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Schroder, Astrid A1 - Gemballa, Teresa A1 - Ruppin, Steffie A1 - Wartenburger, Isabell T1 - German norms for semantic typicality, age of acquisition, and concept familiarity JF - Behavior research methods : a journal of the Psychonomic Society N2 - The present study introduces the first substantial German database with norms for semantic typicality, age of acquisition, and concept familiarity for 824 exemplars of 11 semantic categories, including four natural ( and ) and five man-made (, and ) categories, as well as and Each category exemplar in the database was collected empirically in an exemplar generation study. For each category exemplar, norms for semantic typicality, estimated age of acquisition, and concept familiarity were gathered in three different rating studies. Reliability data and additional analyses on effects of semantic category and intercorrelations between age of acquisition, semantic typicality, concept familiarity, word length, and word frequency are provided. Overall, the data show high inter- and intrastudy reliabilities, providing a new resource tool for designing experiments with German word materials. The full database is available in the supplementary material of this file and also at www.psychonomic.org/archive. KW - Semantic typicality KW - Age of acquisition KW - Concept familiarity KW - Norm data KW - Semantic categories KW - German database KW - Lexical-semantic processing KW - Exemplar generation Y1 - 2012 U6 - https://doi.org/10.3758/s13428-011-0164-y SN - 1554-351X VL - 44 IS - 2 SP - 380 EP - 394 PB - Springer CY - New York ER - TY - JOUR A1 - Passow, Susanne A1 - Westerhausen, Rene A1 - Wartenburger, Isabell A1 - Hugdahl, Kenneth A1 - Heekeren, Hauke R. A1 - Lindenberger, Ulman A1 - Li, Shu-Chen T1 - Human aging compromises attentional control of auditory perception JF - Psychology and aging N2 - Older adults often experience hearing difficulties in multitalker situations. Attentional control of auditory perception is crucial in situations where a plethora of auditory inputs compete for further processing. We combined an intensity-modulated dichotic listening paradigm with attentional manipulations to study adult age differences in the interplay between perceptual saliency and attentional control of auditory processing. When confronted with two competing sources of verbal auditory input, older adults modulated their attention less flexibly and were more driven by perceptual saliency than younger adults. These findings suggest that aging severely impairs the attentional regulation of auditory perception. KW - aging KW - auditory perception KW - attention KW - dichotic listening KW - hearing Y1 - 2012 U6 - https://doi.org/10.1037/a0025667 SN - 0882-7974 VL - 27 IS - 1 SP - 99 EP - 105 PB - American Psychological Association CY - Washington ER - TY - CHAP A1 - Lausberg, H. A1 - Kazzer, Philipp A1 - Heekeren, Hauke A1 - Wartenburger, Isabell T1 - Differential cortical mechanisms underlying tool use, pantomime, and body-part-as-object use T2 - European journal of neurology : the official journal of the European Federation of Neurological Societies Y1 - 2012 SN - 1351-5101 VL - 19 IS - 9 SP - 78 EP - 78 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Bos, Laura S. A1 - Hanne, Sandra A1 - Wartenburger, Isabell A1 - Bastiaanse, Roelien T1 - Losing track of time? Processing of time reference inflection in agrammatic and healthy speakers of German JF - Neuropsychologia : an international journal in behavioural and cognitive neuroscience N2 - Background: Individuals with agrammatic aphasia (IWAs) have problems with grammatical decoding of tense inflection. However, these difficulties depend on the time frame that the tense refers to. Verb morphology with reference to the past is more difficult than with reference to the non-past, because a link needs to be made to the past event in discourse, as captured in the PAst Discourse Linking Hypothesis (PADILIH; Bastiaanse, R., Bamyaci, E., Hsu, C., Lee, J., Yarbay Duman, T., Thompson, C. K., 2011. Time reference in agrammatic aphasia: A cross-linguistic study. J. Neurolinguist. 24, 652-673). With respect to reference to the (non-discourse-linked) future, data so far indicate that IWAs experience less difficulties as compared to past time reference (Bastiaanse, R., Bamyaci, E., Hsu, C., Lee, J., Yarbay Duman, T., Thompson, C. K., 2011. Time reference in agrammatic aphasia: A cross-linguistic study. J. Neurolinguist. 24, 652-673), supporting the assumptions of the PADILIH. Previous online studies of time reference in aphasia used methods such as reaction times analysis (e.g., Faroqi-Shah, Y., Dickey, M. W., 2009. On-line processing of tense and temporality in agrammatic aphasia. Brain Lang. 108, 97-111). So far, no such study used eye-tracking, even though this technique can bring additional insights (Burchert, F., Hanne, S., Vasishth, S., 2013. Sentence comprehension disorders in aphasia: the concept of chance performance revisited. Aphasiology 27, 112-125, doi:10.1080/02687038.2012.730603). Aims: This study investigated (1) whether processing of future and past time reference inflection differs between non-brain-damaged individuals (NBDs) and IWAs, and (2) underlying mechanisms of time reference comprehension failure by IWAs. Results and discussion: NBDs scored at ceiling and significantly higher than the IWAs. IWAs had below-ceiling performance on the future condition, and both participant groups were faster to respond to the past than to the future condition. These differences are attributed to a pre-existing preference to look at a past picture, which has to be overcome. Eye movement patterns suggest that both groups interpret future time reference similarly, while IWAs show a delay relative to NBDs in interpreting past time reference inflection. The eye tracking results support the PADILIH, because processing reference to the past in discourse syntax requires additional resources and thus, is problematic and delayed for people with aphasia. (C) 2014 Elsevier Ltd. All rights reserved. KW - Visual-world paradigm KW - Spoken language comprehension KW - Time reference KW - Morphology KW - Agrammatism KW - Eye-tracking KW - Aphasia KW - Discourse linking Y1 - 2014 U6 - https://doi.org/10.1016/j.neuropsychologia.2014.10.026 SN - 0028-3932 SN - 1873-3514 VL - 65 SP - 180 EP - 190 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Lausberg, Hedda A1 - Kazzer, Philipp A1 - Heekeren, Hauke R. A1 - Wartenburger, Isabell T1 - Pantomiming tool use with an imaginary tool in hand as compared to demonstration with tool in hand specifically modulates the left middle and superior temporal gyri JF - Cortex : a journal devoted to the study of the nervous system and behaviour N2 - Neuropsychological lesion studies evidence the necessity to differentiate between various forms of tool-related actions such as real tool use, tool use demonstration with tool in hand and without physical target object, and pantomime without tool in hand. However, thus far, neuroimaging studies have primarily focused only on investigating tool use pantomimes. The present fMRI study investigates pantomime without tool in hand as compared to tool use demonstration with tool in hand in order to explore patterns of cerebral signal modulation associated with acting with imaginary tools in hand. Fifteen participants performed with either hand (i) tool use pantomime with an imaginary tool in hand in response to visual tool presentation and (ii) tool use demonstration with tool in hand in response to visual-tactile tool presentation. In both conditions, no physical target object was present. The conjunction analysis of the right and left hands executions of tool use pantomime relative to tool use demonstration yielded significant activity in the left middle and superior temporal lobe. In contrast, demonstration relative to pantomime revealed large bihemispherically distributed homologous areas of activity. Thus far, fMRI studies have demonstrated the relevance of the left middle and superior temporal gyri in viewing, naming, and matching tools and related actions and contexts. Since in our study all these factors were equally (ir)relevant both in the tool use pantomime and the tool use demonstration conditions, the present findings enhance the knowledge about the function of these brain regions in tool-related cognitive processes. The two contrasted conditions only differ regarding the fact that the pantomime condition requires the individual to act with an imaginary tool in hand. Therefore, we suggest that the left middle and superior temporal gyri are specifically involved in integrating the projected mental image of a tool in the execution of a tool-specific movement concept. (C) 2015 Elsevier Ltd. All rights reserved. KW - Tool use pantomime KW - Tool use demonstration KW - Mental image KW - Left middle and superior temporal gyri KW - Hemispheric specialization Y1 - 2015 SN - 0010-9452 SN - 1973-8102 VL - 71 SP - 1 EP - 14 PB - Elsevier CY - Milano ER -