TY  - JOUR
A1  - Kallies, Gunnar
A1  - Rapp, Michael Armin
A1  - Fydrich, Thomas
A1  - Fehm, Lydia
A1  - Tschorn, Mira
A1  - Teran, Christina
A1  - Schwefel, Melanie
A1  - Pietrek, Anou F.
A1  - Henze, Romy
A1  - Hellweg, Rainer
A1  - Ströhle, Andreas
A1  - Heinzel, Stephan
A1  - Heissel, Andreas
T1  - Serum brain-derived neurotrophic factor (BDNF) at rest and after acute aerobic exercise in major depressive disorder
JF  - Psychoneuroendocrinology
N2  - Physiological mechanisms of an anti-depressive effect of physical exercise in major depressive disorder (MDD) seem to involve alterations in brain-derived neurotrophic factor (BDNF) level. However, previous studies which investigated this effect in a single bout of exercise, did not control for confounding peripheral factors that contribute to BDNF-alterations. Therefore, the underlying cause of exercise-induced BDNF-changes remains unclear. The current study aims to investigate serum BDNF (sBDNF)-changes due to a single-bout of graded aerobic exercise in a group of 30 outpatients with MDD, suggesting a more precise analysis method by taking plasma volume shift and number of platelets into account. Results show that exercise-induced increases in sBDNF remain significant (p<.001) when adjusting for plasma volume shift and controlling for number of platelets. The interaction of sBDNF change and number of platelets was also significant (p=.001) indicating larger sBDNF-increase in participants with smaller number of platelets. Thus, findings of this study suggest an involvement of peripheral as well as additional possibly brain-derived mechanisms explaining exercise-related BDNF release in MDD. For future studies in the field of exercise-related BDNF research, the importance of controlling for peripheral parameters is emphasized.
KW  - Brain-derived neurotrophic factor (BDNF)
KW  - Platelets
KW  - Major depressive disorder
KW  - Physical exercise
Y1  - 2018
U6  - https://doi.org/10.1016/j.psyneuen.2018.12.015
SN  - 0306-4530
VL  - 102
SP  - 212
EP  - 215
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Petzold, Moritz Bruno
A1  - Mumm, Jennifer Lara Maria
A1  - Bischoff, Sophie
A1  - Große, Julia
A1  - Plag, Jens
A1  - Brand, Ralf
A1  - Ströhle, Andreas
T1  - Increasing physical activity and healthy diet in outpatients with mental disorders
BT  - a randomized-controlled evaluation of two psychological interventions
JF  - European archives of psychiatry and clinical neuroscience : official organ of the German Society for Biological Psychiatry
N2  - IntroductionWhile physical activity (PA) can play an important role in the treatment of mental disorders (MD), large proportions of patients with MD do not meet PA recommendations. The aim of this trial was to evaluate whether structured psychological intervention (MoVo-LISA) is effective in helping outpatients with MD to increase their level of PA. As active control group (CG) we modified MoVo-LISA to target healthy diet behavior.MethodsN=83 outpatients with MD (F1-F4) were randomized to the two conditions. PA (self-report and accelerometry), dietary behavior, social-cognitive determinants of health behavior change, psychiatric symptoms and health-related quality of life were assessed at baseline, 1 and 12 weeks after the intervention.ResultsSignificant time*group interaction effects for objectively measured PA, dietary behavior and fruit and vegetable consumption indicated differential effects of the interventions on these outcomes. PA increased in the MoVo-LISA group (IG) from baseline to follow-up while it decreased in CG. IG showed a significant higher level of objectively measured PA at follow-up compared to CG. Dietary behavior and fruit and vegetable consumption significantly increased from baseline to follow-up in CG, but not IG. IG showed a significant increase in some, but not all social cognitive determinants of health behavior change.ConclusionsMoVo-LISA is effective in helping outpatients with MD to increase their level of PA in short- and mid-term. The used intervention strategies are effective for the promotion of healthy diet in patients with MD as well.
KW  - Physical activity
KW  - Physical exercise
KW  - Mental disorder
KW  - Mental disease
KW  - Intervention
KW  - MoVo
Y1  - 2018
U6  - https://doi.org/10.1007/s00406-018-0941-z
SN  - 0940-1334
SN  - 1433-8491
VL  - 269
IS  - 5
SP  - 529
EP  - 542
PB  - Springer
CY  - Heidelberg
ER  -