TY  - GEN
A1  - Kaminski, Roland
A1  - Schaub, Torsten H.
A1  - Siegel, Anne
A1  - Videla, Santiago
T1  - Minimal intervention strategies in logical signaling networks with ASP
T2  - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
N2  - Proposing relevant perturbations to biological signaling networks is central to many problems in biology and medicine because it allows for enabling or disabling certain biological outcomes. In contrast to quantitative methods that permit fine-grained (kinetic) analysis, qualitative approaches allow for addressing large-scale networks. This is accomplished by more abstract representations such as logical networks. We elaborate upon such a qualitative approach aiming at the computation of minimal interventions in logical signaling networks relying on Kleene's three-valued logic and fixpoint semantics. We address this problem within answer set programming and show that it greatly outperforms previous work using dedicated algorithms.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 596 
KW  - systems biology
KW  - transduction
KW  - circuits
KW  - models
KW  - sets
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-415704
SN  - 1866-8372
IS  - 4-5
SP  - 675
EP  - 690
ER  -