TY  - JOUR
A1  - Abdolvahab, Rouhollah Haji
A1  - Metzler, Ralf
A1  - Ejtehadi, Mohammad Reza
T1  - First passage time distribution of chaperone driven polymer translocation through a nanopore homopolymer and heteropolymer cases
JF  - The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr
N2  - Combining the advection-diffusion equation approach with Monte Carlo simulations we study chaperone driven polymer translocation of a stiff polymer through a nanopore. We demonstrate that the probability density function of first passage times across the pore depends solely on the Peclet number, a dimensionless parameter comparing drift strength and diffusivity. Moreover it is shown that the characteristic exponent in the power-law dependence of the translocation time on the chain length, a function of the chaperone-polymer binding energy, the chaperone concentration, and the chain length, is also effectively determined by the Peclet number. We investigate the effect of the chaperone size on the translocation process. In particular, for large chaperone size, the translocation progress and the mean waiting time as function of the reaction coordinate exhibit pronounced sawtooth-shapes. The effects of a heterogeneous polymer sequence on the translocation dynamics is studied in terms of the translocation velocity, the probability distribution for the translocation progress, and the monomer waiting times. (C) 2011 American Institute of Physics.
Y1  - 2011
U6  - https://doi.org/10.1063/1.3669427
SN  - 0021-9606
VL  - 135
IS  - 24
PB  - American Institute of Physics
CY  - Melville
ER  -