TY  - JOUR
A1  - Maity, Alok Kumar
A1  - Bandyopadhyay, Arnab
A1  - Chattopadhyay, Sudip
A1  - Chaudhuri, Jyotipratim Ray
A1  - Metzler, Ralf
A1  - Chaudhury, Pinaki
A1  - Banik, Suman K.
T1  - Quantification of noise in bifunctionality-induced post-translational modification
JF  - Physical review : E, Statistical, nonlinear and soft matter physics
N2  - We present a generic analytical scheme for the quantification of fluctuations due to bifunctionality-induced signal transduction within the members of a bacterial two-component system. The proposed model takes into account post-translational modifications in terms of elementary phosphotransfer kinetics. Sources of fluctuations due to autophosphorylation, kinase, and phosphatase activity of the sensor kinase have been considered in the model via Langevin equations, which are then solved within the framework of linear noise approximation. The resultant analytical expression of phosphorylated response regulators are then used to quantify the noise profile of biologically motivated single and branched pathways. Enhancement and reduction of noise in terms of extra phosphate outflux and influx, respectively, have been analyzed for the branched system. Furthermore, the role of fluctuations of the network output in the regulation of a promoter with random activation-deactivation dynamics has been analyzed.
Y1  - 2013
U6  - https://doi.org/10.1103/PhysRevE.88.032716
SN  - 1539-3755
VL  - 88
IS  - 3
PB  - American Physical Society
CY  - College Park
ER  -