TY - JOUR ED - Becker, Rolf ED - Lauterbach, Wolfgang T1 - Bildung als Privileg BT - Erklärungen und Befunde zu den Ursachen der Bildungsungleichheit N2 - Im Anschluss an kontroverse Diskussionen über dauerhafte Bildungsungleichheiten stellt das vorliegende Buch detailliert aus sozialwissenschaftlicher Perspektive zentrale Ursachen für sozial ungleiche Bildungschancen in den Mittelpunkt der Betrachtung. Im vorliegenden Band werden daher aktueller Stand empirischer Bildungsforschung diskutiert und neue Analysen vorgelegt. Ziel ist es, in systematischer Weise soziale Mechanismen aufzuzeigen, die zur Entstehung und Reproduktion von Bildungsungleichheiten beitragen. Y1 - 2016 SN - 978-3-658-11951-5 SN - 978-3-658-11952-2 U6 - https://doi.org/10.1007/978-3-658-11952-2 PB - Springer CY - Wiesbaden ET - 5., aktual. ER - TY - JOUR A1 - Lazarides, Rebecca A1 - Rubach, Charlott A1 - Ittel, Angela T1 - Adolescents’ perceptions of socializers’ beliefs, career-related conversations, and motivation in mathematics JF - Developmental psychology N2 - Research based on the Eccles model of parent socialization demonstrated that parents are an important source of value and ability information for their children. Little is known, however, about the bidirectional effects between students’ perceptions of their parents’ beliefs and behaviors and the students’ own domain-specific values. This study analyzed how students’ perceptions of parents’ beliefs and behaviors and students’ mathematics values and mathematics-related career plans affect each other bidirectionally, and analyzed the role of students’ gender as a moderator of these relations. Data from 475 students in 11th and 12th grade (girls: 50.3%; 31 classrooms; 12 schools), who participated in 2 waves of the study, were analyzed. Results of longitudinal structural equation models demonstrated that students’ perceptions of their parents’ mathematics value beliefs at Time 1 affected the students’ own mathematics utility value at Time 2. Bidirectional effects were not shown in the full sample but were identified for boys. The paths within the tested model varied for boys and girls. For example, boys’, not girls’, mathematics intrinsic value predicted their reported conversations with their fathers about future occupational plans. Boys’, not girls’, perceived parents’ mathematics value predicted the mathematics utility value. Findings are discussed in relation to their implications for parents and teachers, as well as in relation to gendered motivational processes. KW - parents’ beliefs KW - parent–child conversations KW - motivation KW - mathematics KW - gender Y1 - 2016 U6 - https://doi.org/10.1037/dev0000270 SN - 0012-1649 SN - 1939-0599 VL - 53 IS - 3 SP - 525 EP - 539 PB - American Psychological Association CY - Washington ER - TY - JOUR A1 - Hedayat Mahmoudi, Mahdi A1 - Schulze, Bert-Wolfgang T1 - Corner boundary value problems JF - Asian-European journal of mathematics N2 - The paper develops some crucial steps in extending the first-order cone or edge calculus to higher singularity orders. We focus here on order 2, but the ideas are motivated by an iterative approach for higher singularities. KW - Mellin operators KW - Mellin oscillatory integrals KW - exit calculus KW - weighted Sobolev spaces Y1 - 2016 U6 - https://doi.org/10.1142/S1793557117500541 SN - 1793-5571 SN - 1793-7183 VL - 10 IS - 1 PB - World Scientific CY - Singapore ER - TY - JOUR A1 - Salamat, Mona A1 - Zare, Mehdi A1 - Holschneider, Matthias A1 - Zöller, Gert T1 - Calculation of Confidence Intervals for the Maximum Magnitude of Earthquakes in Different Seismotectonic Zones of Iran JF - Pure and applied geophysics N2 - The problem of estimating the maximum possible earthquake magnitude m(max) has attracted growing attention in recent years. Due to sparse data, the role of uncertainties becomes crucial. In this work, we determine the uncertainties related to the maximum magnitude in terms of confidence intervals. Using an earthquake catalog of Iran, m(max) is estimated for different predefined levels of confidence in six seismotectonic zones. Assuming the doubly truncated Gutenberg-Richter distribution as a statistical model for earthquake magnitudes, confidence intervals for the maximum possible magnitude of earthquakes are calculated in each zone. While the lower limit of the confidence interval is the magnitude of the maximum observed event, the upper limit is calculated from the catalog and the statistical model. For this aim, we use the original catalog which no declustering methods applied on as well as a declustered version of the catalog. Based on the study by Holschneider et al. (Bull Seismol Soc Am 101(4): 1649-1659, 2011), the confidence interval for m(max) is frequently unbounded, especially if high levels of confidence are required. In this case, no information is gained from the data. Therefore, we elaborate for which settings finite confidence levels are obtained. In this work, Iran is divided into six seismotectonic zones, namely Alborz, Azerbaijan, Zagros, Makran, Kopet Dagh, Central Iran. Although calculations of the confidence interval in Central Iran and Zagros seismotectonic zones are relatively acceptable for meaningful levels of confidence, results in Kopet Dagh, Alborz, Azerbaijan and Makran are not that much promising. The results indicate that estimating mmax from an earthquake catalog for reasonable levels of confidence alone is almost impossible. KW - Maximum magnitude of earthquake KW - Level of confidence KW - Confidence interval Y1 - 2016 U6 - https://doi.org/10.1007/s00024-016-1418-5 SN - 0033-4553 SN - 1420-9136 VL - 174 SP - 763 EP - 777 PB - Springer CY - Basel ER - TY - JOUR A1 - Schmidt, Burkhard A1 - Lorenz, Ulf T1 - WavePacket BT - a Matlab package for numerical quantum dynamics. I: Closed quantum systems and discrete variable representations JF - Computer physics communications : an international journal devoted to computational physics and computer programs in physics N2 - WavePacket is an open-source program package for the numerical simulation of quantum-mechanical dynamics. It can be used to solve time-independent or time-dependent linear Schrödinger and Liouville–von Neumann-equations in one or more dimensions. Also coupled equations can be treated, which allows to simulate molecular quantum dynamics beyond the Born–Oppenheimer approximation. Optionally accounting for the interaction with external electric fields within the semiclassical dipole approximation, WavePacket can be used to simulate experiments involving tailored light pulses in photo-induced physics or chemistry. The graphical capabilities allow visualization of quantum dynamics ‘on the fly’, including Wigner phase space representations. Being easy to use and highly versatile, WavePacket is well suited for the teaching of quantum mechanics as well as for research projects in atomic, molecular and optical physics or in physical or theoretical chemistry. The present Part I deals with the description of closed quantum systems in terms of Schrödinger equations. The emphasis is on discrete variable representations for spatial discretization as well as various techniques for temporal discretization. The upcoming Part II will focus on open quantum systems and dimension reduction; it also describes the codes for optimal control of quantum dynamics. The present work introduces the MATLAB version of WavePacket 5.2.1 which is hosted at the Sourceforge platform, where extensive Wiki-documentation as well as worked-out demonstration examples can be found. KW - Schrodinger equation KW - Quantum dynamics KW - Numerical propagation KW - Bound states KW - Discrete variable representation KW - Non-adiabatic transitions Y1 - 0207 U6 - https://doi.org/10.1016/j.cpc.2016.12.007 SN - 0010-4655 SN - 1879-2944 VL - 213 SP - 223 EP - 234 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kreibich, Heidi A1 - Botto, Anna A1 - Merz, Bruno A1 - Schröter, Kai T1 - Probabilistic, Multivariable Flood Loss Modeling on the Mesoscale with BT-FLEMO JF - Risk analysis N2 - Flood loss modeling is an important component for risk analyses and decision support in flood risk management. Commonly, flood loss models describe complex damaging processes by simple, deterministic approaches like depth-damage functions and are associated with large uncertainty. To improve flood loss estimation and to provide quantitative information about the uncertainty associated with loss modeling, a probabilistic, multivariable Bagging decision Tree Flood Loss Estimation MOdel (BT-FLEMO) for residential buildings was developed. The application of BT-FLEMO provides a probability distribution of estimated losses to residential buildings per municipality. BT-FLEMO was applied and validated at the mesoscale in 19 municipalities that were affected during the 2002 flood by the River Mulde in Saxony, Germany. Validation was undertaken on the one hand via a comparison with six deterministic loss models, including both depth-damage functions and multivariable models. On the other hand, the results were compared with official loss data. BT-FLEMO outperforms deterministic, univariable, and multivariable models with regard to model accuracy, although the prediction uncertainty remains high. An important advantage of BT-FLEMO is the quantification of prediction uncertainty. The probability distribution of loss estimates by BT-FLEMO well represents the variation range of loss estimates of the other models in the case study. KW - Damage modeling KW - multiparameter KW - probabilistic KW - uncertainty KW - validation Y1 - 2016 U6 - https://doi.org/10.1111/risa.12650 SN - 0272-4332 SN - 1539-6924 VL - 37 IS - 4 SP - 774 EP - 787 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Rybski, Diego A1 - Reusser, Dominik Edwin A1 - Winz, Anna-Lena A1 - Fichtner, Christina A1 - Sterzel, Till A1 - Kropp, Jürgen T1 - Cities as nuclei of sustainability? JF - Environment and Planning B: Urban Analytics and City Science N2 - We have assembled CO2 emission figures from collections of urban GHG emission estimates published in peer-reviewed journals or reports from research institutes and non-governmental organizations. Analyzing the scaling with population size, we find that the exponent is development dependent with a transition from super- to sub-linear scaling. From the climate change mitigation point of view, the results suggest that urbanization is desirable in developed countries. Further, we compare this analysis with a second scaling relation, namely the fundamental allometry between city population and area, and propose that density might be a decisive quantity too. Last, we derive the theoretical country-wide urban emissions by integration and obtain a dependence on the size of the largest city. KW - Scaling KW - cities KW - climate change KW - development process KW - allometry Y1 - 2017 U6 - https://doi.org/10.1177/0265813516638340 SN - 2399-8083 SN - 2399-8091 VL - 44 IS - 3 SP - 425 EP - 440 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Laurinaviehyute, Anna K. A1 - Chrabaszcz, Anna V. A1 - Farizova, Nina O. A1 - Tolkacheva, Valeria A. A1 - Dragoy, Olga V. T1 - Влияние сенсомоторных стереотипоВ на понимание пространстВенных конструкций BT - данные дВижений глаз BT - evidence from eye-tracking JF - Voprosy Jazykoznanij N2 - In an eye-tracking study we tested the hypothesis that comprehension is facilitated by a match between the order of the verb and its arguments in a sentence and the order of the actual sensorimotor interaction with these objects (for example, in the phrase put the bag into the box, the order of the arguments corresponds to the order of motor actions: take the bag, put it into the box) could facilitate comprehension of such constructions. We tested 40 native Russian speakers in a visual world sentence-picture matching task. In prepositional constructions, there was no difference between conditions that matched or mismatched sensorimotor stereotypes, whereas in instrumental constructions, sensorimotor stereotypes facilitated comprehension. T2 - The influence of sensorimotor stereotypes on thecomprehension of spatial constructions KW - embodied cognition KW - eye-tracking KW - language comprehension KW - reversible constructions KW - sensorimotor bias Y1 - 2016 U6 - https://doi.org/10.31857/S0373658X0001002-1 SN - 0373-658X IS - 3 SP - 99 EP - 109 PB - Nauka CY - Moskva ER - TY - JOUR A1 - Kalkuhl, Matthias A1 - Edenhofer, Ottmar T1 - Ramsey meets Thünen BT - the impact of land taxes on economic development and land conservation JF - International tax and public finance N2 - Land taxes can increase production in the manufacturing sector and enhance land conservation at the same time, which can lead to overall macroeconomic growth. Existing research emphasizes the non-distorting properties of land taxes (when fixed factors are taxed) as well as growth-enhancing impacts (when asset portfolios are shifted to reproducible capital). This paper furthers the neoclassical perspective on land taxes by endogenizing land allocation decisions in a multi-sector growth model. Based on von Thünen’s observation, agricultural land is created from wilderness through conversion and cultivation, both of which are associated with costs. In the steady state of our general equilibrium model, land taxes not only may reduce land consumption (associated with environmental benefits) but may also affect overall economic output, while leaving wages and interest rates unaffected. When labor productivity is higher in the manufacturing than in the agricultural sector and agricultural and manufactured goods are substitutes (or the economy is open to world trade), land taxes increase aggregate economic output. There is a complex interplay of conservation policy, technological change and land taxes, depending on consumer preferences, sectoral labor productivities and openness-to-trade. Our model introduces a new perspective on land taxes in current policy debates on development, tax reforms as well as forest conservation. KW - Structural shift KW - Structural change KW - REDD KW - Henry George KW - Forest conservation KW - Sustainability KW - Johann Heinrich von Thunen Y1 - 2016 U6 - https://doi.org/10.1007/s10797-016-9403-6 SN - 0927-5940 SN - 1573-6970 VL - 24 SP - 350 EP - 380 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Gaubert, Philippe A1 - Patel, Riddhi P. A1 - Veron, Geraldine A1 - Goodman, Steven M. A1 - Willsch, Maraike A1 - Vasconcelos, Raquel A1 - Lourenco, Andre A1 - Sigaud, Marie A1 - Justy, Fabienne A1 - Joshi, Bheem Dutt A1 - Fickel, Jörns A1 - Wilting, Andreas T1 - Phylogeography of the Small Indian Civet and Origin of Introductions to Western Indian Ocean Islands JF - The journal of heredity : official journal of the American Genetic Association N2 - The biogeographic dynamics affecting the Indian subcontinent, East and Southeast Asia during the Plio-Pleistocene has generated complex biodiversity patterns. We assessed the molecular biogeography of the small Indian civet (Viverricula indica) through mitogenome and cytochrome b + control region sequencing of 89 historical and modern samples to (1) establish a time-calibrated phylogeography across the species’ native range and (2) test introduction scenarios to western Indian Ocean islands. Bayesian phylogenetic analyses identified 3 geographic lineages (East Asia, sister-group to Southeast Asia and the Indian subcontinent + northern Indochina) diverging 3.2–2.3 million years ago (Mya), with no clear signature of past demographic expansion. Within Southeast Asia, Balinese populations separated from the rest 2.6–1.3 Mya. Western Indian Ocean populations were assigned to the Indian subcontinent + northern Indochina lineage and had the lowest mitochondrial diversity. Approximate Bayesian computation did not distinguish between single versus multiple introduction scenarios. The early diversification of the small Indian civet was likely shaped by humid periods in the Late Pliocene–Early Pleistocene that created evergreen rainforest barriers, generating areas of intra-specific endemism in the Indian subcontinent, East, and Southeast Asia. Later, Pleistocene dispersals through drier conditions in South and Southeast Asia were likely, giving rise to the species’ current natural distribution. Our molecular data supported the delineation of only 4 subspecies in V. indica, including an endemic Balinese lineage. Our study also highlighted the influence of prefirst millennium AD introductions to western Indian Ocean islands, with Indian and/or Arab traders probably introducing the species for its civet oil. KW - Asia KW - biogeography KW - civet oil KW - mtDNA KW - Plio-Pleistocene KW - Viverridae Y1 - 2016 U6 - https://doi.org/10.1093/jhered/esw085 SN - 0022-1503 SN - 1465-7333 VL - 108 SP - 270 EP - 279 PB - Oxford Univ. Press CY - Cary ER - TY - JOUR A1 - Kutzschbach, Martin A1 - Wunder, Bernd A1 - Krstulovic, Marija A1 - Ertl, Andreas A1 - Trumbull, Robert B. A1 - Rocholl, Alexander A1 - Giester, Gerald T1 - First high-pressure synthesis of rossmanitic tourmaline and evidence for the incorporation of Li at the X site JF - Physics and chemistry of minerals / in cooperation with the International Mineralogical Association (IMA) N2 - Lithium is an important component of some tourmalines, especially in chemically evolved granites and pegmatites. All attempts at synthesizing Li-rich tourmaline have so far been unsuccessful. Here we describe the first synthesis of rossmanitic tourmaline at 4 GPa and 700 degrees C in the system Li2OAl2O3SiO2B2O3H2O (LASBH) from seed-free solid starting materials consisting of a homogenous mixture of Li2O, gamma-Al2O3, quartz and H3BO3. The solid run products after 12-day run duration comprise rossmanitic tourmaline (68 wt%), dumortierite (28 wt%) and traces of spodumene (3 wt%) and coesite (1 wt%). Tourmaline forms idiomorphic, large prismatic crystals (30 X 100 mu m), which are inclusion free and chemically unzoned. The refined cell dimensions of the tourmaline are: a = 15.7396(9) angstrom, c = 7.0575(5) angstrom, V = 1514.1(2) angstrom 3. Conventionally, the Li+ ion is assumed to exclusively occupy the octahedral Y site in the tourmaline structure to a maximum of 2 Li per formula unit (pfu). However, the chemical composition of our synthetic tourmaline determined by electron microprobe and secondary ion mass spectroscopy results in the formula: (X)(square Li-0.67(11)(0.33(11)))(Y)(Al2.53(10)Li0.47(10))(Z)(Al-6)T(Si5.42(15)B0.58(15))O-18(B)(BO3)(3)(V+W)[(OH)(2.40(3))O-1.60(3)], wherein a significant amount of Li occupies the X site for charge balance requirements. Reliable assignment of the OH-stretching vibrations in a polarized single-crystal Raman spectrum such as a single-crystal XRD structure refinement, confirms the incorporation of Li at the X site [0.24(9) and 0.15(5) Li-X pfu, respectively]. The SREF data show that the LiO1 distances are shortened significantly in order to compensate for the smaller ionic radius of Li+ compared to Na+, K+ or Ca2+ at the X site, i.e., Li is closer to the Si6O18 ring and to a sevenfold coordination with oxygen. KW - High-pressure synthesis KW - Tourmaline KW - Rossmanite KW - Crystal chemistry KW - X site occupancy KW - SIMS KW - SREF KW - Li isotope fractionation Y1 - 2016 U6 - https://doi.org/10.1007/s00269-016-0863-0 SN - 0342-1791 SN - 1432-2021 VL - 44 SP - 353 EP - 363 PB - Springer CY - New York ER - TY - JOUR A1 - Felser, Claudia A1 - Drummer, Janna-Deborah T1 - Sensitivity to Crossover Constraints During Native and Non-native Pronoun Resolution JF - Journal of psycholinguistic research N2 - We report the results from two experiments examining native and non-native German speakers’ sensitivity to crossover constraints on pronoun resolution. Our critical stimuli sentences contained personal pronouns in either strong (SCO) or weak crossover (WCO) configurations. Using eye-movement monitoring during reading and a gender-mismatch paradigm, Experiment 1 investigated whether a fronted wh-phrase would be considered as a potential antecedent for a pronoun intervening between the wh-phrase and its canonical position. Both native and non-native readers initially attempted coreference in WCO but not in SCO configurations, as evidenced by early gender-mismatch effects in our WCO conditions. Experiment 2 was an offline antecedent judgement task whose results mirrored the SCO/WCO asymmetry observed in our reading-time data. Taken together, our results show that the SCO constraint immediately restricts pronoun interpretation in both native and non-native comprehension, and further suggest that SCO and WCO constraints derive from different sources. KW - Strong crossover KW - Weak crossover KW - Pronoun resolution KW - Eye-movement monitoring KW - German Y1 - 2016 U6 - https://doi.org/10.1007/s10936-016-9465-8 SN - 0090-6905 SN - 1573-6555 VL - 46 SP - 771 EP - 789 PB - Springer CY - New York ER - TY - JOUR A1 - Doerr, Benjamin A1 - Neumann, Frank A1 - Sutton, Andrew M. T1 - Time Complexity Analysis of Evolutionary Algorithms on Random Satisfiable k-CNF Formulas JF - Algorithmica : an international journal in computer science N2 - We contribute to the theoretical understanding of randomized search heuristics by investigating their optimization behavior on satisfiable random k-satisfiability instances both in the planted solution model and the uniform model conditional on satisfiability. Denoting the number of variables by n, our main technical result is that the simple () evolutionary algorithm with high probability finds a satisfying assignment in time when the clause-variable density is at least logarithmic. For low density instances, evolutionary algorithms seem to be less effective, and all we can show is a subexponential upper bound on the runtime for densities below . We complement these mathematical results with numerical experiments on a broader density spectrum. They indicate that, indeed, the () EA is less efficient on lower densities. Our experiments also suggest that the implicit constants hidden in our main runtime guarantee are low. Our main result extends and considerably improves the result obtained by Sutton and Neumann (Lect Notes Comput Sci 8672:942-951, 2014) in terms of runtime, minimum density, and clause length. These improvements are made possible by establishing a close fitness-distance correlation in certain parts of the search space. This approach might be of independent interest and could be useful for other average-case analyses of randomized search heuristics. While the notion of a fitness-distance correlation has been around for a long time, to the best of our knowledge, this is the first time that fitness-distance correlation is explicitly used to rigorously prove a performance statement for an evolutionary algorithm. KW - Runtime analysis KW - Satisfiability KW - Fitness-distance correlation Y1 - 2016 U6 - https://doi.org/10.1007/s00453-016-0190-3 SN - 0178-4617 SN - 1432-0541 VL - 78 SP - 561 EP - 586 PB - Springer CY - New York ER - TY - JOUR A1 - Richtberg, Samantha A1 - Jakob, Marion A1 - Hoefling, Volkmar A1 - Weck, Florian T1 - Patient Characteristics and Patient Behavior as Predictors of Outcome in Cognitive Therapy and Exposure Therapy for Hypochondriasis JF - Journal of clinical psychology N2 - ObjectivePsychotherapy for hypochondriasis has greatly improved over the last decades and cognitive-behavioral treatments are most promising. However, research on predictors of treatment outcome for hypochondriasis is rare. Possible predictors of treatment outcome in cognitive therapy (CT) and exposure therapy (ET) for hypochondriasis were investigated. MethodCharacteristics and behaviors of 75 patients were considered as possible predictors: sociodemographic variables (sex, age, and cohabitation); psychopathology (pretreatment hypochondriacal symptoms, comorbid mental disorders, and levels of depression, anxiety, and somatic symptoms); and patient in-session interpersonal behavior. ResultsSeverity of pretreatment hypochondriacal symptoms, comorbid mental disorders, and patient in-session interpersonal behavior were significant predictors in multiple hierarchical regression analyses. Interactions between the predictors and the treatment (CT or ET) were not found. ConclusionsIn-session interpersonal behavior is an important predictor of outcome. Furthermore, there are no specific contraindications to treating hypochondriasis with CT or ET. KW - cognitive-behavioral therapy KW - hypochondriasis KW - illness anxiety disorder KW - interpersonal behavior KW - predictors of outcome Y1 - 2016 U6 - https://doi.org/10.1002/jclp.22356 SN - 0021-9762 SN - 1097-4679 VL - 73 IS - 6 SP - 612 EP - 625 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Schlosser, Rainer T1 - Stochastic dynamic pricing and advertising in isoelastic oligopoly models JF - European Journal of Operational Research N2 - In this paper, we analyze stochastic dynamic pricing and advertising differential games in special oligopoly markets with constant price and advertising elasticity. We consider the sale of perishable as well as durable goods and include adoption effects in the demand. Based on a unique stochastic feedback Nash equilibrium, we derive closed-form solution formulas of the value functions and the optimal feedback policies of all competing firms. Efficient simulation techniques are used to evaluate optimally controlled sales processes over time. This way, the evolution of optimal controls as well as the firms’ profit distributions are analyzed. Moreover, we are able to compare feedback solutions of the stochastic model with its deterministic counterpart. We show that the market power of the competing firms is exactly the same as in the deterministic version of the model. Further, we discover two fundamental effects that determine the relation between both models. First, the volatility in demand results in a decline of expected profits compared to the deterministic model. Second, we find that saturation effects in demand have an opposite character. We show that the second effect can be strong enough to either exactly balance or even overcompensate the first one. As a result we are able to identify cases in which feedback solutions of the deterministic model provide useful approximations of solutions of the stochastic model. KW - Pricing KW - Advertising KW - Stochastic differential games KW - Oligopoly competition KW - Adoption effects Y1 - 2017 U6 - https://doi.org/10.1016/j.ejor.2016.11.021 SN - 0377-2217 SN - 1872-6860 VL - 259 SP - 1144 EP - 1155 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Edlich, Alexander A1 - Gerecke, Christian A1 - Giulbudagian, Michael A1 - Neumann, Falko A1 - Hedtrich, Sarah A1 - Schaefer-Korting, Monika A1 - Ma, Nan A1 - Calderon, Marcelo A1 - Kleuser, Burkhard T1 - Specific uptake mechanisms of well-tolerated thermoresponsive polyglycerol-based nanogels in antigen-presenting cells of the skin JF - European Journal of Pharmaceutics and Biopharmaceutics N2 - Engineered nanogels are of high value for a targeted and controlled transport of compounds due to the ability to change their chemical properties by external stimuli. As it has been indicated that nanogels possess a high ability to penetrate the stratum corneum, it cannot be excluded that nanogels interact with dermal dendritic cells, especially in diseased skin. In this study the potential crosstalk of the thermore-sponsive nanogels (tNGs) with the dendritic cells of the skin was investigated with the aim to determine the immunotoxicological properties of the nanogels. The investigated tNGs were made of dendritic polyglycerol (dPG) and poly(glycidyl methyl ether-co-ethyl glycidyl ether) (p(GME-co-EGE)), as polymer conferring thermoresponsive properties. Although the tNGs were taken up, they displayed neither cytotoxic and genotoxic effects nor any induction of reactive oxygen species in the tested cells. Interestingly, specific uptake mechanisms of the tNGs by the dendritic cells were depending on the nanogels cloud point temperature (Tcp), which determines the phase transition of the nanoparticle. The study points to caveolae-mediated endocytosis as being the major tNGs uptake mechanism at 37 degrees C, which is above the Tcp of the tNGs. Remarkably, an additional uptake mechanism, beside caveolae-mediated endocytosis, was observed at 29 degrees C, which is the Tcp of the tNGs. At this temperature, which is characterized by two different states of the tNGs, macropinocytosis was involved as well. In summary, our study highlights the impact of thermoresponsivity on the cellular uptake mechanisms which has to be taken into account if the tNGs are used as a drug delivery system. KW - Dendritic cells KW - Drug delivery systems KW - Nanogel KW - Nanoparticle KW - Nanoparticle uptake KW - Nanotoxicology Y1 - 2017 U6 - https://doi.org/10.1016/j.ejpb.2016.12.016 SN - 0939-6411 SN - 1873-3441 VL - 116 SP - 155 EP - 163 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kornhuber, Kai A1 - Petoukhov, Vladimir A1 - Petri, Stefan A1 - Rahmstorf, Stefan A1 - Coumou, Dim T1 - Evidence for wave resonance as a key mechanism for generating high-amplitude quasi-stationary waves in boreal summer JF - Climate dynamics : observational, theoretical and computational research on the climate system N2 - Several recent northern hemisphere summer extremes have been linked to persistent high-amplitude wave patterns (e.g. heat waves in Europe 2003, Russia 2010 and in the US 2011, Floods in Pakistan 2010 and Europe 2013). Recently quasi-resonant amplification (QRA) was proposed as a mechanism that, when certain dynamical conditions are fulfilled, can lead to such high-amplitude wave events. Based on these resonance conditions a detection scheme to scan reanalysis data for QRA events in boreal summer months was implemented. With this objective detection scheme we analyzed the occurrence and duration of QRA events and the associated atmospheric flow patterns in 1979-2015 reanalysis data. We detect a total number of 178 events for wave 6, 7 and 8 and find that during roughly one-third of all high amplitude events QRA conditions were met for respective waves. Our analysis reveals a significant shift for quasi-stationary waves 6 and 7 towards high amplitudes during QRA events, lagging first QRA-detection by typically one week. The results provide further evidence for the validity of the QRA hypothesis and its important role in generating high amplitude waves in boreal summer. KW - Rossby waves KW - Wave resonance KW - Atmospheric dynamics KW - Extreme weather Y1 - 2016 U6 - https://doi.org/10.1007/s00382-016-3399-6 SN - 0930-7575 SN - 1432-0894 VL - 49 SP - 1961 EP - 1979 PB - Springer CY - New York ER - TY - JOUR A1 - Jung, Janis Moritz A1 - Krahé, Barbara A1 - Busching, Robert T1 - Beyond the positive reinforcement of aggression BT - Peers’ acceptance of aggression promotes aggression via external control beliefs JF - International Journal of Behavioral Development N2 - Being surrounded by peers who are accepting of aggression is a significant predictor of the development and persistence of aggression in childhood and adolescence. Whereas past research has focused on social reinforcement mechanisms as the underlying processes, the present longitudinal study analysed the role of external control beliefs as an additional mediator explaining the link between peers’ acceptance of aggression and the development of aggressive behaviour. Drawing on a large community sample of N = 1,466 male and female children and adolescents from Germany aged between 10 and 18 years, results of latent structural equation modeling were consistent with the hypotheses that peer acceptance of aggression would predict external control beliefs in the social domain, which in turn, should predict aggressive behaviour over time. Additional multigroup analyses showed that the predicted pathways were consistent across gender and age groups. KW - adolescence KW - aggression KW - aggressive peers KW - childhood KW - control beliefs KW - Germany KW - longitudinal Y1 - 2016 U6 - https://doi.org/10.1177/0165025416671613 SN - 0165-0254 SN - 1464-0651 VL - 42 IS - 1 SP - 73 EP - 82 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Jung, Janis Moritz A1 - Krahé, Barbara A1 - Bondü, Rebecca A1 - Esser, Günter A1 - Wyschkon, Anne T1 - Dynamic progression of antisocial behavior in childhood and adolescence BT - a three-wave longitudinal study from Germany JF - Applied Developmental Science N2 - This longitudinal study from Germany examined the dynamic progression of antisocial behavior in childhood and adolescence based on the social interactional model by Patterson, DeBaryshe, and Ramsey. It examined the link between antisocial behavior, social rejection, academic failure, and affiliation with deviant peers in a sample of 1,657 children and youths aged between 6 and 15 years who were studied at three measurement waves (T1 to T3) over a time period of about 5 years. Teachers rated the children on all variables, parents additionally provided ratings of antisocial behavior and social rejection. Latent structural equation modeling yielded the predicted positive paths from antisocial behavior at T1 to social rejection and academic failure at T2. As predicted, affiliation with deviant peers at T2 was positively associated with social rejection and academic failure at the same measurement point. Finally, affiliation with deviant peers at T2 significantly predicted antisocial behavior at T3. Y1 - 2016 U6 - https://doi.org/10.1080/10888691.2016.1219228 SN - 1088-8691 SN - 1532-480X VL - 22 IS - 1 SP - 74 EP - 88 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Zakariás, Lilla A1 - Keresztes, Attila A1 - Marton, Klara A1 - Wartenburger, Isabell T1 - Positive effects of a computerised working memory and executive function JF - Neuropsychological rehabilitation N2 - Aphasia, the language disorder following brain damage, is frequently accompanied by deficits of working memory (WM) and executive functions (EFs). Recent studies suggest that WM, together with certain EFs, can play a role in sentence comprehension in individuals with aphasia (IWA), and that WM can be enhanced with intensive practice. Our aim was to investigate whether a combined WM and EF training improves the understanding of spoken sentences in IWA. We used a pre-post-test case control design. Three individuals with chronic aphasia practised an adaptive training task (a modified n-back task) three to four times a week for a month. Their performance was assessed before and after the training on outcome measures related to WM and spoken sentence comprehension. One participant showed significant improvement on the training task, another showed a tendency for improvement, and both of them improved significantly in spoken sentence comprehension. The third participant did not improve on the training task, however, she showed improvement on one measure of spoken sentence comprehension. Compared to controls, two individuals improved at least in one condition of the WM outcome measures. Thus, our results suggest that a combined WM and EF training can be beneficial for IWA. KW - Aphasia rehabilitation KW - transfer effect KW - updating training KW - interference control KW - sentence comprehension deficit Y1 - 2016 U6 - https://doi.org/10.1080/09602011.2016.1159579 SN - 0960-2011 SN - 1464-0694 VL - 28 IS - 3 SP - 369 EP - 386 PB - Routledge, Taylor & Francis Group CY - Abingdon ER -