TY - BOOK A1 - Dieter, Heribert T1 - Globalisierung à la carte BT - Demokratie, Nationalstaat und die Zukunft europäischer und globaler Zusammenarbeit T3 - Bundeszentrale für Politische Bildung: Schriftenreihe ; Band 10146 Y1 - 2017 SN - 978-3-7425-0146-2 PB - Bundeszentrale für politische Bildung CY - Bonn ER - TY - JOUR A1 - Meiser, Susanne A1 - Esser, Günter T1 - Interpersonal Stress Generation-A Girl Problem? BT - The Role of Depressive Symptoms, Dysfunctional Attitudes, and Gender in Early Adolescent Stress Generation JF - Journal of early adolescence N2 - To provide further insight into stress generation patterns in boys and girls around puberty, this study investigated longitudinal reciprocal relations between depressive symptoms, dysfunctional attitudes, and stress generation, the process by which individuals contribute to the occurrence of stress in interpersonal contexts (e.g., problematic social interactions) or in noninterpersonal contexts (e.g., achievement problems). A community sample of N = 924 German children and early adolescents (51.8% male) completed depressive symptoms and dysfunctional attitudes measures at T1 and again 20 months later (T2). Stressful life events were reported at T2. Dysfunctional attitudes were unrelated to stress generation. Interpersonal, but not noninterpersonal, dependent stress partially mediated the relationship between initial and later depressive symptoms, with girls being more likely to generate interpersonal stress in response to depressive symptoms. Findings underscore the role of interpersonal stress generation in the early development of depressive symptomatology, and in the gender difference in depression prevalence emerging around puberty. KW - stress generation KW - depression KW - dysfunctional attitudes KW - children and adolescents KW - gender differences Y1 - 2017 U6 - https://doi.org/10.1177/0272431617725197 SN - 0272-4316 SN - 1552-5449 VL - 39 IS - 1 SP - 41 EP - 66 PB - Sage Publ. CY - Thousand Oaks ER - TY - JOUR A1 - Daviter, Falk T1 - Policy analysis in the face of complexity BT - What kind of knowledge to tackle wicked problems? JF - Public policy and administration N2 - An ever-increasing number of policy problems have come to be interpreted as representing a particular type of intractable, ill-structured or wicked policy problem. Much of this debate is concerned with the challenges wicked problems pose for program management rather than policy analysis. This article, in contrast, argues that the key challenge in addressing this type of policy problems is in fact analytical. Wicked policy problems are difficult to identify and interpret. The knowledge base for analysing wicked policy problem is typically fragmented and contested. Available evidence is incomplete, inconclusive and incommensurable. In this situation, the evidentiary and the interpretative elements of policy analysis become increasingly indistinguishable and inseparably intertwined. The article reveals the problems this poses for policy analysis and explores the extent to which the consolidation, consensualization and contestation of evidence in policy analysis offer alternative procedural paths to resolve these problems. KW - Evidence-based policy making KW - expertise KW - knowledge KW - policy analysis KW - wicked problems Y1 - 2017 U6 - https://doi.org/10.1177/0952076717733325 SN - 0952-0767 SN - 1749-4192 VL - 34 IS - 1 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Warschburger, Petra T1 - Jugendliche und junge Erwachsene mit Adipositas T1 - Adolescents and Young Adults BT - Wie sollte in ihren Augen „die perfekte Therapie“ aussehen? BT - What Would a "Perfect Therapy" Look Like? JF - Die Rehabilitation : Zeitschrift für Praxis und Forschung in der Rehabilitation N2 - Hauptziel Adipositas ist eine der Hauptindikationen in der Kinder- und Jugend-Rehabilitation. Für ältere Jugendliche und junge Erwachsene fehlen altersspezifische Therapieangebote fast vollständig. Ziel war es die Wünsche bezüglich der Inhalte und Methoden einer „perfekten Therapie“ im Rahmen eines Rehabilitationsaufenthalts zu untersuchen. Methode Im Rahmen der YOUTH-Studie wurden 147 adipöse Jugendliche und junge Erwachsene beiderlei Geschlechts (zwischen 15 und 21 Jahren) mithilfe eines standardisierten Fragebogens befragt. Ergebnis Insgesamt zeigten sich relativ wenige alters- und geschlechtsspezifische Unterschiede. Interdisziplinär geleitete, koedukative Gruppen mit Elterneinbindung wurden gewünscht. Wichtige Themen waren gesunde Ernährung sowie psychosoziale Aspekte. Auch der Prävention von Rückfällen wurde eine hohe Relevanz zugeschrieben. Schlussfolgerung Psychosoziale Aspekte und die Vorbereitung auf mögliche Rückfallsituationen sollten integraler Bestandteil der Therapie sein. N2 - Principal objective Obesity is a major indication for pediatric and adolescent-rehabilitation. Age-specific therapies for „emerging adults“ are lacking. The aim was to examine the patients’ preferences with respect to the contents and methods of the „perfect therapy“ within an inpatient setting. Method In the context of the YOUTH study 147 obese male and female adolescents (aged 15–21 years) filled in standardized questionnaires. Results Overall little age- and gender-specific differences were observed. The participants expressed a preference for interdisciplinary coordinated and coeducational group approaches with involvement of the parents. Major topics were healthy nutrition and psychosocial aspects. Prevention of relapses is considered as important as well. Conclusion Psychosocial aspects and preparing coping with risk situations should be an integral part of treatment programs. KW - obesity KW - adolescents KW - young adults KW - therapy KW - requirements KW - Jugendliche KW - junge Erwachsene KW - Therapie KW - Anforderungen KW - Adipositas Y1 - 2017 U6 - https://doi.org/10.1055/s-0043-107930 SN - 0034-3536 SN - 1439-1309 VL - 57 IS - 5 SP - 295 EP - 302 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Weiß, Norman T1 - Origin and Further Development JF - The Council of Europe Y1 - 2017 SN - 978-0-19-967252-3 SP - 3 EP - 22 PB - Oxford University Press CY - Oxford ER - TY - CHAP A1 - Klein, Eckart ED - Schmahl, Stefanie ED - Breuer, Marten T1 - Membership and Observer Status T2 - The Council of Europe : its law and politics Y1 - 2017 SN - 978-0-19-967252-3 SP - 41 EP - 92 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Schotter, Elizabeth Roye A1 - Leinenger, Mallorie A1 - von der Malsburg, Titus Raban T1 - When your mind skips what your eyes fixate BT - how forced fixations lead to comprehension illusions in reading JF - Psychonomic bulletin & review : a journal of the Psychonomic Society N2 - The phenomenon of forced fixations suggests that readers sometimes fixate a word (due to oculomotor constraints) even though they intended to skip it (due to parafoveal cognitive-linguistic processing). We investigate whether this leads readers to look directly at a word but not pay attention to it. We used a gaze-contingent boundary paradigm to dissociate parafoveal and foveal information (e.g., the word phone changed to scarf once the reader's eyes moved to it) and asked questions about the sentence to determine which one the reader encoded. When the word was skipped or fixated only briefly (i.e., up to 100 ms) readers were more likely to report reading the parafoveal than the fixated word, suggesting that there are cases in which readers look directly at a word but their minds ignore it, leading to the illusion of reading something they did not fixate. KW - Word recognition KW - Text comprehension KW - Eye movements and reading Y1 - 2017 U6 - https://doi.org/10.3758/s13423-017-1356-y SN - 1069-9384 SN - 1531-5320 VL - 25 IS - 5 SP - 1884 EP - 1890 PB - Springer CY - New York ER - TY - JOUR A1 - Matuschek, Hannes A1 - Kliegl, Reinhold T1 - On the ambiguity of interaction and nonlinear main effects in a regime of dependent covariates JF - Behavior research methods : a journal of the Psychonomic Society N2 - The analysis of large experimental datasets frequently reveals significant interactions that are difficult to interpret within the theoretical framework guiding the research. Some of these interactions actually arise from the presence of unspecified nonlinear main effects and statistically dependent covariates in the statistical model. Importantly, such nonlinear main effects may be compatible (or, at least, not incompatible) with the current theoretical framework. In the present literature, this issue has only been studied in terms of correlated (linearly dependent) covariates. Here we generalize to nonlinear main effects (i.e., main effects of arbitrary shape) and dependent covariates. We propose a novel nonparametric method to test for ambiguous interactions where present parametric methods fail. We illustrate the method with a set of simulations and with reanalyses (a) of effects of parental education on their children’s educational expectations and (b) of effects of word properties on fixation locations during reading of natural sentences, specifically of effects of length and morphological complexity of the word to be fixated next. The resolution of such ambiguities facilitates theoretical progress. KW - Interaction effects KW - Mixed models KW - Additive mixed models KW - Regression splines KW - Non-parametric curve estimation Y1 - 2017 U6 - https://doi.org/10.3758/s13428-017-0956-9 SN - 1554-351X SN - 1554-3528 VL - 50 IS - 5 SP - 1882 EP - 1894 PB - Springer CY - New York ER - TY - CHAP A1 - Klein, Eckart ED - Schmahl, Stefanie ED - Breuer, Marten T1 - Seat and Symbols of the Council of Europe T2 - The Council of Europe : its law and politics Y1 - 2017 SN - 978-0-19-967252-3 SP - 93 EP - 107 PB - Oxford University Press CY - Oxford ER - TY - CHAP A1 - Weiß, Norman T1 - Programmes of Cooperation and Solidarity T2 - The Council of Europe : its law and policies Y1 - 2017 SN - 978-0-19-967252-3 SP - 788 EP - 798 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Fedchenko, Dmitry A1 - Tarkhanov, Nikolai Nikolaevich T1 - A Rado theorem for the porous medium equation JF - Boletin de la Sociedad Matemática Mexicana N2 - We prove that if u is a locally Lipschitz continuous function on an open set chi subset of Rn + 1 satisfying the nonlinear heat equation partial derivative(t)u = Delta(vertical bar u vertical bar(p-1) u), p > 1, weakly away from the zero set u(-1) (0) in chi, then u is a weak solution to this equation in all of chi. KW - Quasilinear equations KW - Removable sets KW - Porous medium equation Y1 - 2017 U6 - https://doi.org/10.1007/s40590-017-0169-3 SN - 1405-213X SN - 2296-4495 VL - 24 IS - 2 SP - 427 EP - 437 PB - Springer CY - Cham ER - TY - GEN A1 - Ahnert, Thomas A1 - Decultot, Elisabeth A1 - Grote, Simon A1 - Lifschitz, Avi T1 - The German Enlightenment T2 - German history : the journal of the German History Societ N2 - The term Enlightenment (or Aufklärung) remains heavily contested. Even when historians delimit the remit of the concept, assigning it to a particular historical period rather than to an intellectual or moral programme, the public resonance of the Enlightenment remains high and problematic—especially when equated in an essentialist manner with modernity or some core values of ‘the West’. This Forum has been convened to discuss recent research on the Enlightenment in Germany, different views of the term and its ideological use in public discourse outside academia (and sometimes within it). KW - Enlightenment KW - Aufklarung KW - historiography KW - eighteenth century Y1 - 2017 U6 - https://doi.org/10.1093/gerhis/ghx104 SN - 0266-3554 SN - 1477-089X VL - 35 SP - 588 EP - 602 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Haile, Mekbib Gebretsadik A1 - Kalkuhl, Matthias A1 - Algieri, Bernardina A1 - Gebreselassie, Samuel T1 - Price shock transmission BT - evidence from the wheat-bread market value chain in Ethiopia JF - Agricultural economics N2 - This study assesses the degree of vertical price transmission along the wheat-bread value chain in Ethiopia. This is pursued by applying a vector error correction model and an impulse response analysis using monthly price data for the period 2000-2015. Our analysis considers transmission of price shocks across different market levels, including from the international and domestic wheat grain markets at the upstream to the domestic wheat bread market at the downstream of the value chain. The empirical findings indicate that significant cointegration exists across prices of the different market stages. There is a transmission from international prices to domestic prices at downstream markets, in particular to flour and bread prices. Prices at upstream markets are largely influenced by the domestic wholesale market. In general, the speed of adjustment is quite slow with a half-life of about one year for restoring the equilibrium price relationship. As price margins between the different market stages in the value chain have substantially decreased in the last 15 years, higher transmission, and thus exposure to international market shocks, can be expected in the future. The results also show that causal relationships exist between prices at different market stageswith the wholesale market identified as the key market level where prices and price expectations are formed. KW - Q02 KW - Q11 KW - Q13 KW - L11 KW - M31 KW - Value chain KW - Price transmission KW - Impulse response KW - Wheat KW - Ethiopia Y1 - 2017 U6 - https://doi.org/10.1111/agec.12373 SN - 0169-5150 SN - 1574-0862 VL - 48 IS - 6 SP - 769 EP - 780 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Guerrero-Ramirez, Nathaly Rokssana A1 - Craven, Dylan A1 - Reich, Peter B. A1 - Ewel, John J. A1 - Isbell, Forest A1 - Koricheva, Julia A1 - Parrotta, John A. A1 - Auge, Harald A1 - Erickson, Heather E. A1 - Forrester, David I. A1 - Hector, Andy A1 - Joshi, Jasmin Radha A1 - Montagnini, Florencia A1 - Palmborg, Cecilia A1 - Piotto, Daniel A1 - Potvin, Catherine A1 - Roscher, Christiane A1 - van Ruijven, Jasper A1 - Tilman, David A1 - Wilsey, Brian A1 - Eisenhauer, Nico T1 - Diversity-dependent temporal divergence of ecosystem functioning in experimental ecosystems JF - Nature ecology & evolution N2 - The effects of biodiversity on ecosystem functioning generally increase over time, but the underlying processes remain unclear. Using 26 long-term grassland and forest experimental ecosystems, we demonstrate that biodiversity-ecosystem functioning relationships strengthen mainly by greater increases in functioning in high-diversity communities in grasslands and forests. In grasslands, biodiversity effects also strengthen due to decreases in functioning in low-diversity communities. Contrasting trends across grasslands are associated with differences in soil characteristics. Y1 - 2017 U6 - https://doi.org/10.1038/s41559-017-0325-1 SN - 2397-334X VL - 1 IS - 11 SP - 1639 EP - 1642 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Rein, Patrick A1 - Ramson, Stefan A1 - Lincke, Jens A1 - Felgentreff, Tim A1 - Hirschfeld, Robert T1 - Group-Based Behavior Adaptation Mechanisms in Object-Oriented Systems JF - IEEE software N2 - Dynamic and distributed systems require behavior adaptations for groups of objects. Group-based behavior adaptation mechanisms scope adaptations to objects matching conditions beyond class membership. The specification of groups can be explicit or implicit. KW - group-based behavior adaptation KW - lively groups KW - ContextErlang KW - entity-component-system KW - predicated generic functions KW - active layers KW - reactive object queries KW - context groups KW - implied methods KW - object-oriented languages KW - software engineering KW - software development KW - contextual-variability modeling Y1 - 2017 U6 - https://doi.org/10.1109/MS.2017.4121224 SN - 0740-7459 SN - 1937-4194 VL - 34 IS - 6 SP - 78 EP - 82 PB - Inst. of Electr. and Electronics Engineers CY - Los Alamitos ER - TY - JOUR A1 - Fitzi, Gregor A1 - Marcucci, Nicola T1 - Durkheim in Germany BT - the performance of a classic JF - Journal of Classical Sociology Y1 - 2017 U6 - https://doi.org/10.1177/1468795X17735991 SN - 1468-795X SN - 1741-2897 VL - 17 IS - 4 SP - 271 EP - 275 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Fitzi, Gregor T1 - Dialogue. Divergence. Veiled Reception. Criticism: Georg Simmel’s relationship with Emile Durkheim JF - Journal of Classical Sociology N2 - Simmel was the only German sociologist who directly cooperated with Durkheim. After an initial impression of convergence between the sociology of social facts and the sociology of social forms, a break between the two founders of sociology became inevitable. Yet, Durkheim and Simmel went on positioning themselves against one other in the years ahead. Durkheim’s allegation of ‘individual psychologism’ induced Simmel to a veiled reception of Durkheim’s methodological approach that permitted him to refine the sociological epistemology he eventually presented in the Soziologie published in 1908. On this basis, he was able to formulate a final criticism of the sociology of social facts as a social psychology. KW - Sociology of social facts KW - sociology of social forms KW - moral sociology KW - transnormative sociology KW - criticism of social psychology Y1 - 2017 U6 - https://doi.org/10.1177/1468795X17735994 SN - 1468-795X SN - 1741-2897 VL - 17 SP - 293 EP - 308 PB - Sage Publ. CY - London ER - TY - GEN A1 - Fitzi, Gregor A1 - Joas, Hans A1 - Marcucci, Nicola T1 - Interview by Gregor Fitzi and Nicola Marcucci with Hans Joas on the reception of Emile Durkheim in Germany. Berlin: Humboldt University of Berlin, 6 October 2014 T2 - Journal of Classical Sociology N2 - The interview offers a reconstruction of the German reception of Durkheim since the middle of the 1970s. Hans Joas, who was one of its major protagonists, discusses the backdrop that finally permitted a scholarly examination of Durkheim’s sociology in Germany. Focussing on his personal reception Joas then gives an account of the Durkheimian themes that inspire his work. KW - Durkheim KW - human rights KW - modernity Y1 - 2017 U6 - https://doi.org/10.1177/1468795X17736131 SN - 1468-795X SN - 1741-2897 VL - 17 IS - 4 SP - 382 EP - 398 PB - Sage Publ. CY - London ER - TY - GEN A1 - Fitzi, Gregor A1 - Marcucci, Nicola A1 - Müller, Hans-Peter T1 - Interview by Gregor Fitzi and Nicola Marcucci with Hans-Peter Müller on the reception of Emile Durkheim in Germany. Berlin: Humboldt University of Berlin, 25 February 2015 T2 - Journal of Classical Sociology N2 - Just after the publication of the Theory of Communicative Action in 1981, a new generation of interpreters started a different reception of Durkheim in Germany. Hans-Peter Müller, sociologist and editor of the German translation of Leçons de sociologie, reconstructs the history of the German Durkheim’s Reception and illuminates the reasons for his interest in the French sociologist. He delivers different insights into the background which permitted the post-Habermasian generation to reach a new understanding of Durkheim’s work by enlightening the scientific and political conditions from which this new sensibility emerged. KW - Durkheim’s German Reception, Max Weber, Georg Simmel, Jürgen Habermas Y1 - 2017 U6 - https://doi.org/10.1177/1468795X17736132 SN - 1468-795X SN - 1741-2897 VL - 17 IS - 4 SP - 399 EP - 422 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Groop, Per-Henrik A1 - Cooper, Mark E. A1 - Perkovic, Vlado A1 - Hocher, Berthold A1 - Kanasaki, Keizo A1 - Haneda, Masakazu A1 - Schernthaner, Guntram A1 - Sharma, Kumar A1 - Stanton, Robert C. A1 - Toto, Robert A1 - Cescutti, Jessica A1 - Gordat, Maud A1 - Meinicke, Thomas A1 - Koitka-Weber, Audrey A1 - Thiemann, Sandra A1 - von Eynatten, Maximilian T1 - Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction BT - the randomized MARLINA-T2D trial JF - Diabetes obesity & metabolism : a journal of pharmacology and therapeutics N2 - Aims: The MARLINA-T2D study (ClinicalTrials. gov, NCT01792518) was designed to investigate the glycaemic and renal effects of linagliptin added to standard-of-care in individuals with type 2 diabetes and albuminuria. Methods: A total of 360 individuals with type 2 diabetes, HbA1c 6.5% to 10.0% (48-86 mmol/ mol), estimated glomerular filtration rate (eGFR) >= 30 mL/min/1.73 m(2) and urinary albumin-tocreatinine ratio (UACR) 30-3000 mg/g despite single agent renin-angiotensin-system blockade were randomized to double-blind linagliptin (n = 182) or placebo (n = 178) for 24 weeks. The primary and key secondary endpoints were change from baseline in HbA1c at week 24 and time-weighted average of percentage change from baseline in UACR over 24 weeks, respectively. Results: Baseline mean HbA1c and geometric mean (gMean) UACR were 7.8% +/- 0.9% (62.2 +/- 9.6 mmol/mol) and 126 mg/g, respectively; 73.7% and 20.3% of participants had microalbuminuria or macroalbuminuria, respectively. After 24 weeks, the placebo-adjusted mean change in HbA1c from baseline was -0.60% (-6.6 mmol/mol) (95% confidence interval [CI], -0.78 to -0.43 [-8.5 to -4.7 mmol/mol]; P <.0001). The placebo-adjusted gMean for time-weighted average of percentage change in UACR from baseline was -6.0% (95% CI, -15.0 to 3.0; P =.1954). The adverse-event profile, including renal safety and change in eGFR, was similar between the linagliptin and placebo groups. Conclusions: In individuals at early stages of diabetic kidney disease, linagliptin significantly improved glycaemic control but did not significantly lower albuminuria. There was no significant change in placebo-adjusted eGFR. Detection of clinically relevant renal effects of linagliptin may require longer treatment, as its main experimental effects in animal studies have been to reduce interstitial fibrosis rather than alter glomerular haemodynamics. KW - antidiabetic drug KW - clinical trial KW - diabetic nephropathy KW - DPP-IV inhibitor KW - glycaemic control KW - linagliptin Y1 - 2017 U6 - https://doi.org/10.1111/dom.13041 SN - 1462-8902 SN - 1463-1326 VL - 19 IS - 11 SP - 1610 EP - 1619 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Morandi, Bertrand A1 - Kail, Jochem A1 - Tödter, Anne A1 - Wolter, Christian A1 - Piegay, Herve T1 - Diverse Approaches to Implement and Monitor River Restoration BT - a Comparative Perspective in France and Germany JF - Environmental Management N2 - River restoration is a main emphasis of river management in European countries. Cross-national comparisons of its implementation are still rare in scientific literature. Based on French and German national censuses, this study compares river restoration practices and monitoring by analysing 102 French and 270 German projects. This comparison aims to draw a spatial and temporal framework of restoration practices in both countries to identify potential drivers of cross-national similarities and differences. The results underline four major trends: (1) a lag of almost 15 years in river restoration implementation between France and Germany, with a consequently higher share of projects in Germany than in France, (2) substantial similarities in restored reach characteristics, short reach length, small rivers, and in "agricultural" areas, (3) good correspondences between stressors identified and restoration measures implemented. Morphological alterations were the most important highlighted stressors. River morphology enhancement, especially instream enhancements, were the most frequently implemented restoration measures. Some differences exist in specific restoration practices, as river continuity restoration were most frequently implemented in French projects, while large wood introduction or channel re-braiding were most frequently implemented in German projects, and (4) some quantitative and qualitative differences in monitoring practices and a significant lack of project monitoring, especially in Germany compared to France. These similarities and differences between Germany and France in restoration application and monitoring possibly result from a complex set of drivers that might be difficult to untangle (e.g., environmental, technical, political, cultural). KW - River restoration KW - Project monitoring KW - Hydromorphologic alteration KW - Mitigation measures KW - France KW - Germany Y1 - 2017 U6 - https://doi.org/10.1007/s00267-017-0923-3 SN - 0364-152X SN - 1432-1009 VL - 60 SP - 931 EP - 946 PB - Springer CY - New York ER - TY - JOUR A1 - Gast, Klaus A1 - Schüler, Anja A1 - Wolff, Martin A1 - Thalhammer, Anja A1 - Berchtold, Harald A1 - Nagel, Norbert A1 - Lenherr, Gudrun A1 - Hauck, Gerrit A1 - Seckler, Robert T1 - Rapid-acting and human insulins BT - Hexamer Dissociation Kinetics upon Dilution of the Pharmaceutical Formulation JF - Pharmaceutical research N2 - Comparison of the dissociation kinetics of rapid-acting insulins lispro, aspart, glulisine and human insulin under physiologically relevant conditions. Dissociation kinetics after dilution were monitored directly in terms of the average molecular mass using combined static and dynamic light scattering. Changes in tertiary structure were detected by near-UV circular dichroism. Glulisine forms compact hexamers in formulation even in the absence of Zn2+. Upon severe dilution, these rapidly dissociate into monomers in less than 10 s. In contrast, in formulations of lispro and aspart, the presence of Zn2+ and phenolic compounds is essential for formation of compact R6 hexamers. These slowly dissociate in times ranging from seconds to one hour depending on the concentration of phenolic additives. The disadvantage of the long dissociation times of lispro and aspart can be diminished by a rapid depletion of the concentration of phenolic additives independent of the insulin dilution. This is especially important in conditions similar to those after subcutaneous injection, where only minor dilution of the insulins occurs. Knowledge of the diverging dissociation mechanisms of lispro and aspart compared to glulisine will be helpful for optimizing formulation conditions of rapid-acting insulins. KW - circular dichroism KW - dissociation kinetics KW - insulin analog KW - light scattering KW - rapid-acting Y1 - 2017 U6 - https://doi.org/10.1007/s11095-017-2233-0 SN - 0724-8741 SN - 1573-904X VL - 34 IS - 795 SP - 2270 EP - 2286 PB - Springer CY - New York ER - TY - JOUR A1 - Ferrer-Maestro, Juan José A1 - Kunst, Christiane A1 - Hernández de la Fuente, David A1 - Faber, Eike T1 - Prólogo JF - Entre los mundos: homenaje a Pedro Barceló = Zwischen den Welten : Festschrift für Pedro Barceló Y1 - 2017 SN - 978-2-84867-578-7 SP - 13 EP - 17 PB - Presses universitaires de Franche-Comté CY - Besançon ER - TY - JOUR A1 - Ferrer-Maestro, Juan José A1 - Kunst, Christiane A1 - Hernández de la Fuente, David A1 - Faber, Eike T1 - Vorwort JF - Entre los mundos: homenaje a Pedro Barceló = Zwischen den Welten : Festschrift für Pedro Barceló Y1 - 2017 SN - 978-2-84867-578-7 SP - 19 EP - 24 PB - Presses universitaires de Franche-Comté CY - Besançon ER - TY - JOUR A1 - Faber, Eike T1 - Augustus und die Provinzialen im Reichsdienst JF - Entre los mundos : homenaje a Pedro Barceló = Zwischen den Welten : Festschrift für Pedro Barceló Y1 - 2017 SN - 978-2-84867-578-7 SP - 101 EP - 119 PB - Presses universitaires de Franche-Comté CY - Besançon ER - TY - JOUR A1 - Brütt, Anna Levke A1 - Meister, Ramona A1 - Bernges, Tabea A1 - Moritz, Steffen A1 - Härter, Martin A1 - Kriston, Levente A1 - Kühne, Franziska T1 - Patient involvement in a systematic review BT - Development and pilot evaluation of a patient workshop JF - Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen N2 - Patient involvement (PI) in research is increasingly required as a means to improve relevance and meaningfulness of research results. PI has been widely promoted by the National Institute for Health Research in England in the last years. In Germany, widespread involvement of patients in research is still missing. The methods used to realize PI have been developed mainly in English research contexts, and detailed information on how to involve patients in systematic reviews is rare. Therefore, the aim of the study was that patients contribute and prioritize clinically relevant outcomes to a systematic review on meta-cognitive interventions, and to evaluate a patient workshop as well as patients’ perceptions of research involvement. Seven patients with experience in psychiatric care participated in our workshop. They focused on outcomes pre-defined in the review protocol (e.g., meta-cognitive or cognitive changes, symptomatology, quality of life), neglected other outcomes (like satisfaction with treatment, acceptability), and added relevant new ones (e.g., scope of action/autonomy, applicability). Altogether, they valued the explicit workshop participation positively. However, some suggested to involve patients at an earlier stage and to adapt the amount of information given. Further systematic reviews would benefit from the involvement of patients in the definition of other components of the review question (like patients or interventions), in the interpretation of key findings or in drafting a lay summary. N2 - Die Beteiligung von Patientinnen und Patienten in der Forschung wird zunehmend gefordert, um die Relevanz und Aussagefähigkeit von Forschungsergebnissen zu verbessern. Während das National Institute for Health Research in England die Patientenbeteiligung seit Jahren fördert, fehlt es in Deutschland noch weitgehend an flächendeckender Forschungsbeteiligung. Zudem liegen Informationen über Methoden der Patientenbeteiligung hauptsächlich für englische Forschungskontexte vor, und detaillierte Informationen zur Patientenbeteiligung in systematischen Reviews sind lückenhaft. Das Ziel der Studie war es daher, dass Patienten klinisch relevante Zielgrößen zu einem systematischen Review zu metakognitiven Interventionen beitragen und priorisieren und dass sie einen Patientenworkshop und ihre wahrgenommene Forschungsbeteiligung bewerten. Sieben psychiatrieerfahrene Patienten nahmen an unserem Workshop teil. Sie benannten Zielgrößen, die im Reviewprotokoll schon vorgesehen waren (z.B. metakognitive und kognitive Veränderungen, Symptomatik, Lebensqualität), vernachlässigten andere Endpunkte (z.B. Zufriedenheit, Akzeptanz) und fügten neue Zielgrößen hinzu (z.B. Handlungsspielräume/Autonomie, Anwendbarkeit). Die Patienten würdigten die Workshopteilnahme insgesamt. Einige empfahlen jedoch eine frühere Beteiligung und eine Anpassung der gegebenen Informationen. Zukünftige systematische Reviews können von der Beteiligung von Patienten bei der Definition weiterer Bestandteile der Fragestellung (wie Population oder Interventionen), der Interpretation zentraler Ergebnisse oder der Formulierung einer allgemeinverständlichen Zusammenfassung profitieren. T2 - Beteiligung von Patienten an einem systematischen Review: Entwicklung und Pilotevaluation eines Patientenworkshops KW - patient involvement KW - patient participation KW - consumer participation KW - systematic review KW - meta-analysis Y1 - 2017 U6 - https://doi.org/10.1016/j.zefq.2017.07.005 SN - 1865-9217 SN - 2212-0289 VL - 127-128 SP - 56 EP - 61 PB - Elsevier CY - Jena ER - TY - JOUR A1 - Miklashevsky, Alex A. T1 - О высоком и низком: пространственная семантика абстрактных и конкретных существительных JF - Tomsk state university journal N2 - Aim and material: In the present study, the data of the rating study presented earlier, where participants estimated the position of an object or phenomenon in vertical space by using the seven-point Likert scale, are used in order to systematically describe spatial information included in language units of different semantic categories. Background: The role of spatial semantics in language understanding is assumed by modern cognition theories and confirmed in experimental studies. Hypotheses: Based on conceptual metaphor theory, a number of hypotheses are proposed in the present study: different semantic categories of nouns (e.g., tools vs. animals vs. emotions etc.) should significantly differ in their spatial semantics as well; different semantic categories of abstract nouns (e.g., mental states vs. emotions vs. physical sensations) should also differ in their spatial semantics, as the latter is included in their conceptual structure; mental states and phenomena (e.g., imagination, thought or memory) should have higher values (i.e., be located higher in the virtual subjective space) than any other abstract concepts; emotional concepts (e.g., love, disgust or happiness) should be located higher than physical sensations (e.g., pain or softness); positive emotions (like joy or euphoria) should be located higher than negative ones (like feeling of guilt or disappointment). Methods: Statistical methods (parametric and non-parametric ones) are used in order to test the hypotheses. As additional cross-testing methods corpora data and expert assessment are included. Results: The results of the study confirmed all the hypotheses. A number of additional regularities were revealed: in general, abstract concepts get higher values on a scale, i.e., are located higher in the virtual subjective space than concrete ones; tool concepts are related more to the lower space, unlike sound concepts that are related to higher space. No difference was found between action concepts (like attack or running) and physical sensations. Discussion: The results obtained can also be explained in terms of other theories within the embodied cognition framework, as it is discussed in the conclusion (words as social tools by A. Borghi and F. Binkofski; ideas by G. Vigliocco and neurosemantic approach by F. Pulvermuller). The need in an integrative model and larger studies with other semantic categories is underlined. N2 - Проведен анализ пространственной семантики различных категорий русских существительных, входящих в психолингви-стическую базуданных; особое внимание уделяется абстрактным концептам. Выявлены различия пространственной семантики наименований физических ощущений и действий, эмоций, ментальных процессов. Полученны ерезультаты обсуждаются с точки зрения отдельных подходов в рамках теории воплощенного познания – теории концептуальной метафоры, теории слов как социальных инструментов (WAT, Words As social Tools), нейросемантики. T2 - About the high and the low: spatial semantics of abstract and concrete nouns KW - embodied cognition KW - spatial semantics KW - conceptual metaphor KW - neurosemantics KW - words as social tools KW - psycholinguistic databases KW - abstract concepts KW - абстрактные концепты KW - психолингвистическая база данных KW - слова как социальные инструменты KW - нейросемантика KW - концептуальная метафора KW - пространственная семантика KW - воплощенное познание Y1 - 2017 U6 - https://doi.org/10.17223/15617793/424/4 SN - 1561-7793 SN - 1561-803X IS - 424 SP - 26 EP - 34 PB - Tomsk Stata Univ CY - Tomsk ER - TY - JOUR A1 - Berry, Scott A1 - Rosa, Stefanie A1 - Howard, Martin A1 - Buhler, Marc A1 - Dean, Caroline T1 - Disruption of an RNA-binding hinge region abolishes LHP1-mediated epigenetic repression JF - Genes & Development N2 - Epigenetic maintenance of gene repression is essential for development. Polycomb complexes are central to this memory, but many aspects of the underlying mechanism remain unclear. LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) binds Polycomb-deposited H3K27me3 and is required for repression of many Polycomb target genes in Arabidopsis. Here we show that LHP1 binds RNA in vitro through the intrinsically disordered hinge region. By independently perturbing the RNA-binding hinge region and H3K27me3 (trimethylation of histone H3 at Lys27) recognition, we found that both facilitate LHP1 localization and H3K27me3 maintenance. Disruption of the RNAbinding hinge region also prevented formation of subnuclear foci, structures potentially important for epigenetic repression. KW - chromatin KW - epigenetics KW - plant biology KW - Polycomb KW - RNA Y1 - 2017 U6 - https://doi.org/10.1101/gad.305227.117 SN - 0890-9369 SN - 1549-5477 VL - 31 SP - 2115 EP - 2120 PB - Cold Spring Harbor Laboratory Press CY - Cold Spring Harbor, NY ER - TY - JOUR A1 - Dimitrova, Ilinka A1 - Koppitz, Jörg T1 - On the semigroup of all partial fence-preserving injections on a finite set JF - Journal of Algebra and Its Applications N2 - For n∈N , let Xn={a1,a2,…,an} be an n-element set and let F=(Xn;