TY  - JOUR
A1  - Huber, Matthias
A1  - Treszl, Andras
A1  - Reibis, Rona Katharina
A1  - Teichmann, Christopher
A1  - Zergibel, Irina
A1  - Bolbrinker, Juliane
A1  - Scholze, Juergen
A1  - Wegscheider, Karl
A1  - Völler, Heinz
A1  - Kreutz, Reinhold
T1  - Genetics of melatonin receptor type 2 is associated with left ventricular function in hypertensive patients treated according to guidelines
JF  - European journal of internal medicine : official journal of the European Federation of Internal Medicine
N2  - Background: Melatonin exerts multiple biological effects with potential impact on human diseases. This is underscored by genetic studies that demonstrated associations between melatonin receptor type 2 gene (MTNR1B) polymorphisms and characteristics of type 2 diabetes. We set out to test the hypothesis whether genetic variants at MTNR1B are also relevant for other disease phenotypes within the cardiovascular continuum. We thus investigated single nucleotide polymorphisms (SNPs) of MTNR1B in relation to blood pressure (BP) and cardiac parameters in hypertensive patients.
 Methods: Patients (n = 605, mean age 56.2 +/- 9.4 years, 82.3% male) with arterial hypertension and cardiac ejection fraction (EF) >= 40% were studied. Cardiac parameters were assessed by echocardiography.
 Results: The cohort comprised subjects with coronary heart disease (73.1%) and myocardial infarction (48.1%) with a mean EF of 63.7 +/- 8.9%. Analysis of SNPs rs10830962, rs4753426, rs12804291, rs10830963, and rs3781638 revealed two haplotypes 1 and 2 with frequencies of 0.402 and 0.277, respectively. Carriers with haplotype 1 (CTCCC) showed compared to non-carriers a higher mean 24-hour systolic BP (difference BP: 2.4 mm Hg, 95% confidence interval (CI): 0.3 to 4.5 mm Hg, p = 0.023). Haplotype 2 (GCCGA) was significantly related to EF with an absolute increase of 1.8% (CI: 0.45 to 3.14%) in carriers versus non-carriers (p = 0.009).
 Conclusion: Genetics of MTNR1B point to impact of the melatonin signalling pathway for BP and left ventricular function. This may support the importance of the melatonin system as a potential therapeutic target.
KW  - Clinical study
KW  - Genetics
KW  - Heart
KW  - Hypertension
KW  - Melatonin receptor type 2
Y1  - 2013
U6  - https://doi.org/10.1016/j.ejim.2013.03.015
SN  - 0953-6205
VL  - 24
IS  - 7
SP  - 650
EP  - 655
PB  - Elsevier
CY  - Amsterdam
ER  -