TY - JOUR A1 - Aa, Han van der A1 - Rebmann, Adrian A1 - Leopold, Henrik T1 - Natural language-based detection of semantic execution anomalies in event logs JF - Information systems : IS ; an international journal ; data bases N2 - Anomaly detection in process mining aims to recognize outlying or unexpected behavior in event logs for purposes such as the removal of noise and identification of conformance violations. Existing techniques for this task are primarily frequency-based, arguing that behavior is anomalous because it is uncommon. However, such techniques ignore the semantics of recorded events and, therefore, do not take the meaning of potential anomalies into consideration. In this work, we overcome this caveat and focus on the detection of anomalies from a semantic perspective, arguing that anomalies can be recognized when process behavior does not make sense. To achieve this, we propose an approach that exploits the natural language associated with events. Our key idea is to detect anomalous process behavior by identifying semantically inconsistent execution patterns. To detect such patterns, we first automatically extract business objects and actions from the textual labels of events. We then compare these against a process-independent knowledge base. By populating this knowledge base with patterns from various kinds of resources, our approach can be used in a range of contexts and domains. We demonstrate the capability of our approach to successfully detect semantic execution anomalies through an evaluation based on a set of real-world and synthetic event logs and show the complementary nature of semantics-based anomaly detection to existing frequency-based techniques. KW - Process mining KW - Natural language processing KW - Anomaly detection Y1 - 2021 U6 - https://doi.org/10.1016/j.is.2021.101824 SN - 0306-4379 SN - 1873-6076 VL - 102 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Abramova, Olga A1 - Gladkaya, Margarita A1 - Krasnova, Hanna T1 - An unusual encounter with oneself BT - exploring the impact of self-view on online meeting outcomes T2 - ICIS 2021: IS and the future of work N2 - Helping overcome distance, the use of videoconferencing tools has surged during the pandemic. To shed light on the consequences of videoconferencing at work, this study takes a granular look at the implications of the self-view feature for meeting outcomes. Building on self-awareness research and self-regulation theory, we argue that by heightening the state of self-awareness, self-view engagement depletes participants’ mental resources and thereby can undermine online meeting outcomes. Evaluation of our theoretical model on a sample of 179 employees reveals a nuanced picture. Self-view engagement while speaking and while listening is positively associated with self-awareness, which, in turn, is negatively associated with satisfaction with meeting process, perceived productivity, and meeting enjoyment. The criticality of the communication role is put forward: looking at self while listening to other attendees has a negative direct and indirect effect on meeting outcomes; however, looking at self while speaking produces equivocal effects. Y1 - 2021 UR - https://aisel.aisnet.org/icis2021/is_future_work/is_future_work/16 PB - AIS Electronic Library (AISeL) CY - [Erscheinungsort nicht ermittelbar] ER - TY - CHAP A1 - Abramova, Olga A1 - Gundlach, Jana A1 - Bilda, Juliane T1 - Understanding the role of newsfeed clutter in stereotype activation BT - the case of Facebook T2 - PACIS 2021 proceedings N2 - Despite the phenomenal growth of Big Data Analytics in the last few years, little research is done to explicate the relationship between Big Data Analytics Capability (BDAC) and indirect strategic value derived from such digital capabilities. We attempt to address this gap by proposing a conceptual model of the BDAC - Innovation relationship using dynamic capability theory. The work expands on BDAC business value research and extends the nominal research done on BDAC – innovation. We focus on BDAC's relationship with different innovation objects, namely product, business process, and business model innovation, impacting all value chain activities. The insights gained will stimulate academic and practitioner interest in explicating strategic value generated from BDAC and serve as a framework for future research on the subject Y1 - 2021 UR - https://aisel.aisnet.org/pacis2021/79 SN - 978-1-7336325-7-7 IS - 473 PB - AIS Electronic Library (AISeL) CY - [Erscheinungsort nicht ermittelbar] ER - TY - THES A1 - Abromeit, Wolfgang T1 - Vertragsgestaltung bei komplexen Verträgen des Staates mit Privaten T2 - Schriften zum öffentlichen Recht N2 - Vertragsgestaltung ist ein praktisch sehr relevantes Thema, das wegen der Justizorientierung in der Wissenschaft noch weitgehend stiefmütterlich behandelt wird. In dieser Untersuchung wird, zumindest für die besonders delikate Konstellation bei komplexen Kooperationen des Staats mit Privaten (ÖPP/PPP), Abhilfe geschaffen. Dabei gründet die Analyse auf einer fundierten Typisierung und Charakterisierung der Probleme solcher Projekte. Den theoretischen Rahmen liefert eine effizienzorientierte Studie institutionenökonomischer Ansätze, namentlich der Transaktionskostentheorie und der Prinzipal-Agenten-Theorie, rückversichert über die praxisorientierten Grundregeln der vertraglichen Risikoverteilung. So gelingt es praktische Formulierungsvorschläge für Standardprobleme der Vertragsgestaltung, wie Leistungsbestimmungen, Anpassungsmechanismen, Konfliktbeilegungsregeln, Informationsmechanismen und Kündigungsregeln zu finden. Diese werden auch aus den Erfolgsbedingungen erläutert. Y1 - 2021 SN - 978-3-428-15802-7 SN - 978-3-428-55802-5 SN - 0582-0200 IS - 1444 PB - Duncker & Humblot CY - Berlin ER - TY - JOUR A1 - AbuJarour, Safa'a A1 - Ajjan, Haya A1 - Fedorowicz, Jane A1 - Köster, Antonia T1 - ICT support for refugees and undocumented immigrants JF - Communications of the Association for Information Systems : CAIS N2 - Immigrant integration has become a primary political concern for leaders in Germany and the United States. The information systems (IS) community has begun to research how information and communications technologies can assist immigrants and refugees, such as by examining how countries can facilitate social-inclusion processes. Migrants face the challenge of joining closed communities that cannot integrate or fear doing so. We conducted a panel discussion at the 2019 Americas Conference on Information Systems (AMCIS) in Cancun, Mexico, to introduce multiple viewpoints on immigration. In particular, the panel discussed how technology can both support and prevent immigrants from succeeding in their quest. We conducted the panel to stimulate a thoughtful and dynamic discussion on best practices and recommendations to enhance the discipline's impact on alleviating the challenges that occur for immigrants in their host countries. In this panel report, we introduce the topic of using ICT to help immigrants integrate and identify differences between North/Central America and Europe. We also discuss how immigrants (particularly refugees) use ICT to connect with others, feel that they belong, and maintain their identity. We also uncover the dark and bright sides of how governments use ICT to deter illegal immigration. Finally, we present recommendations for researchers and practitioners on how to best use ICT to assist with immigration. KW - refugees KW - immigration KW - social inclusion KW - deterrence KW - ICT KW - bright side KW - dark side Y1 - 2020 U6 - https://doi.org/10.17705/1CAIS.04840 SN - 1529-3181 VL - 48 SP - 456 EP - 475 PB - Association for Information Systems CY - New York, NY ER - TY - JOUR A1 - AbuJarour, Safa'a A1 - Ajjan, Haya A1 - Fedorowicz, Jane A1 - Owens, Dawn T1 - How working from home during COVID-19 affects academic productivity JF - Communications of the Association for Information Systems : CAIS N2 - The coronavirus disease of 2019 (COVID-19) pandemic has forced most academics to work from home. This sudden venue change can affect academics' productivity and exacerbate the challenges that confront universities as they face an uncertain future. In this paper, we identify factors that influence academics' productivity while working from home during the mandate to self-isolate. From analyzing results from a global survey we conducted, we found that both personal and technology-related factors affect an individual's attitude toward working from home and productivity. Our results should prove valuable to university administrators to better address the work-life challenges that academics face. KW - work from home KW - academic KW - COVID-19 KW - productivity KW - WFH KW - technology KW - usefulness KW - family-work conflict Y1 - 2021 U6 - https://doi.org/10.17705/1CAIS.04808 SN - 1529-3181 VL - 48 SP - 55 EP - 64 PB - Association for Information Systems CY - New York, NY ER - TY - CHAP A1 - Abujarour, Safa’a A1 - Köster, Antonia A1 - Krasnova, Hanna A1 - Wiesche, Manuel T1 - Technology as a source of power BT - Exploring how ICT use contributes to the social inclusion of refugees in Germany T2 - Proceedings of the 54th Hawaii International Conference on System Sciences N2 - Since the beginning of the recent global refugee crisis, researchers have been tackling many of its associated aspects, investigating how we can help to alleviate this crisis, in particular, using ICTs capabilities. In our research, we investigated the use of ICT solutions by refugees to foster the social inclusion process in the host community. To tackle this topic, we conducted thirteen interviews with Syrian refugees in Germany. Our findings reveal different ICT usages by refugees and how these contribute to feeling empowered. Moreover, we show the sources of empowerment for refugees that are gained by ICT use. Finally, we identified the two types of social inclusion benefits that were derived from empowerment sources. Our results provide practical implications to different stakeholders and decision-makers on how ICT usage can empower refugees, which can foster the social inclusion of refugees, and what should be considered to support them in their integration effort. KW - culture, identity, and inclusion KW - empowerment KW - ict KW - refugees KW - social inclusion KW - technology Y1 - 2021 UR - https://hdl.handle.net/10125/70936 SN - 978-0-9981331-4-0 U6 - https://doi.org/10.24251/HICSS.2021.322 SN - 2572-6862 SP - 2637 EP - 2646 ER - TY - JOUR A1 - Ackfeld, Viola A1 - Rohloff, Tobias A1 - Rzepka, Sylvi T1 - Increasing personal data contributions for the greater public good BT - a field experiment on an online education platform JF - Behavioural public policy N2 - Personal data increasingly serve as inputs to public goods. Like other types of contributions to public goods, personal data are likely to be underprovided. We investigate whether classical remedies to underprovision are also applicable to personal data and whether the privacy-sensitive nature of personal data must be additionally accounted for. In a randomized field experiment on a public online education platform, we prompt users to complete their profiles with personal information. Compared to a control message, we find that making public benefits salient increases the number of personal data contributions significantly. This effect is even stronger when additionally emphasizing privacy protection, especially for sensitive information. Our results further suggest that emphasis on both public benefits and privacy protection attracts personal data from a more diverse set of contributors. KW - field experiment KW - personal data KW - public good KW - privacy Y1 - 2021 U6 - https://doi.org/10.1017/bpp.2021.39 SN - 2398-063X SN - 2398-0648 SP - 1 EP - 27 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Adam, Jan P. A1 - Hahn, Michelle A1 - Hölscher, Ines A1 - Höschel, Heike A1 - Janzen, Stella A1 - Kögel, Lukas T1 - Automatisierung von Routinetätigkeiten im öffentlichen Dienst JF - Verwaltung & Management N2 - Auf Basis einer Umfrage unter 300 Beschäftigten im öffentlichen Dienst untersucht dieser Beitrag, welche möglichen Auswirkungen die Digitale Transformation auf das Tätigkeitsprofil von Mitarbeiterinnen und Mitarbeitern im öffentlichen Sektor haben kann. Zum einen finden sich erste Hinweise auf signifikante Effizienzpotenziale durch Automatisierung im öffentlichen Sektor. Zum anderen wird deutlich, dass die Mitarbeiterinnen und Mitarbeiter dieser Entwicklung mehrheitlich positiv gegenüberstehen und sie aktiv an der Verbesserung von Dienstleistungen mitwirken wollen. Aus diesen Erkenntnissen können zahlreiche Handlungsimplikationen für Veränderungsprojekte in der Praxis abgeleitet werden. Gleichzeitig ruft dieser Beitrag dazu auf, die Folgen der Digitalen Transformation für Mitarbeiterinnen und Mitarbeiter noch besser zu erforschen. Y1 - 2021 U6 - https://doi.org/10.5771/0947-9856-2021-1-39 SN - 0947-9856 SN - 2942-352X VL - 27 IS - 1 SP - 39 EP - 48 PB - Nomos CY - Baden-Baden ER - TY - JOUR A1 - Adam, Maurits A1 - Gumbsch, Christian A1 - Butz, Martin V. A1 - Elsner, Birgit T1 - The impact of action effects on infants’ predictive gaze shifts for a non-human grasping action at 7, 11, and 18 months JF - Frontiers in psychology N2 - During the observation of goal-directed actions, infants usually predict the goal at an earlier age when the agent is familiar (e.g., human hand) compared to unfamiliar (e.g., mechanical claw). These findings implicate a crucial role of the developing agentive self for infants' processing of others' action goals. Recent theoretical accounts suggest that predictive gaze behavior relies on an interplay between infants' agentive experience (top-down processes) and perceptual information about the agent and the action-event (bottom-up information; e.g., agency cues). The present study examined 7-, 11-, and 18-month-old infants' predictive gaze behavior for a grasping action performed by an unfamiliar tool, depending on infants' age-related action knowledge about tool-use and the display of the agency cue of producing a salient action effect. The results are in line with the notion of a systematic interplay between experience-based top-down processes and cue-based bottom-up information: Regardless of the salient action effect, predictive gaze shifts did not occur in the 7-month-olds (least experienced age group), but did occur in the 18-month-olds (most experienced age group). In the 11-month-olds, however, predictive gaze shifts occurred only when a salient action effect was presented. This sheds new light on how the developing agentive self, in interplay with available agency cues, supports infants' action-goal prediction also for observed tool-use actions. KW - infancy KW - predictive gaze behavior KW - eye tracking KW - tool-use actions KW - agency cues KW - developing agentive self KW - non-human grasping Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.695550 SN - 1664-1078 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Adamik, Verena T1 - From Utopian Island to global empire BT - Alex Garland's the Beach JF - Utopian Studies N2 - This article discusses how Alex Garland’s The Beach (1996) engages with conceptions of utopian islands, nation, and colonialism in modernity and how it, from this basis, develops a different spatiality that reflects on a more deterritorialized form of imperial domination within late twentieth-century globalization, as exercised by the United States. The novel is shown to subvert, but not to abolish, two spatial formations that originated in early modernity: nation and utopia. Building on Jean Baudrillard’s elaborations regarding simulation and simulacra, the article argues that The Beach creates a hyperreal narrative that does away with the idea of isolated, bounded spaces and that in form and content corresponds with the worldwide dominance of the United States at the end of the twentieth century. Y1 - 2021 U6 - https://doi.org/doi: 10.5325/utopianstudies.31.3.0457 VL - 31 IS - 3 SP - 457 EP - 474 PB - Penn State University Press CY - University Park, Pa ER - TY - JOUR A1 - Adamik, Verena T1 - Making worlds from literature BT - W.E.B. Du Bois’s The Quest of the Silver Fleece and Dark Princess JF - Thesis eleven : critical theory and historical sociology N2 - While W.E.B. Du Bois’s first novel, The Quest of the Silver Fleece (1911), is set squarely in the USA, his second work of fiction, Dark Princess: A Romance (1928), abandons this national framework, depicting the treatment of African Americans in the USA as embedded into an international system of economic exploitation based on racial categories. Ultimately, the political visions offered in the novels differ starkly, but both employ a Western literary canon – so-called ‘classics’ from Greek, German, English, French, and US American literature. With this, Du Bois attempts to create a new space for African Americans in the world (literature) of the 20th century. Weary of the traditions of this ‘world literature’, the novels complicate and begin to decenter the canon that they draw on. This reading traces what I interpret as subtle signs of frustration over the limits set by the literature that underlies Dark Princess, while its predecessor had been more optimistic in its appropriation of Eurocentric fiction for its propagandist aims. KW - African American literature KW - Eurocentrism KW - genre KW - intertextuality KW - race Y1 - 2021 U6 - https://doi.org/https://doi.org/10.1177/0725513621993308 SN - 0725-5136 SN - 1461-7455 VL - 162 IS - 1 SP - 105 EP - 120 PB - Sage CY - London ER - TY - RPRT A1 - Adriaans, Jule A1 - Griese, Florian A1 - Auspurg, Katrin A1 - Bledow, Nona A1 - Bohmann, Sandra A1 - Busemeyer, Marius R. A1 - Delhey, Jan A1 - Goebel, Jan A1 - Groh-Samberg, Olaf A1 - Heckhausen, Jutta A1 - Hinz, Thomas A1 - Kroh, Martin A1 - Lengfeld, Holger A1 - Lersch, Philipp M. A1 - Liebig, Stefan A1 - Richter, David A1 - Sachweh, Patrick A1 - Schupp, Jürgen A1 - Schwerdt, Guido A1 - Verwiebe, Roland T1 - Dokumentation zum Entwicklungsprozess des Moduls Einstellungen zu sozialer Ungleichheit im SOEP (v38) T2 - SOEP survey papers, series B - survey reports (Methodenberichte) N2 - Im Rahmen eines einjährigen Entwicklungsprozesses wurde das Fragebogenmodul "Einstellungen zu sozialer Ungleichheit" unter der Leitung der Infrastruktureinrichtung SOEP entwickelt und in der 38. Welle der Haupterhebung des Sozio-oekonomischen Panels erstmalig erhoben. Das finale Fragebogenmodul umfasst 43 Items zu den Themenbereichen Soziale Vergleiche, Soziale Mobilität, Sozialstaat und Nicht-materielle Ungleichheit. In der Tradition des SOEP als forschungsbasierte Infrastruktureinrichtung erfolgte die Fragebogenentwicklung in enger Zusammenarbeit mit externen Forschenden aus dem Bereich der Einstellungs- und Ungleichheitsforschung. Neben der etablierten Nutzung des SOEP Innovation Samples (SOEP-IS) für quantitative Pretests neu entwickelter Fragen kam erstmals ein kognitiver Pretest zum Einsatz. Der vorliegende Bericht dokumentiert den Entwicklungsprozess von der Konzeption bis zum finalen Fragebogen. KW - Einstellungen zu sozialer Ungleichheit KW - Fragebogenentwicklung KW - Pretest KW - SOEP KW - SOEP-IS Y1 - 2021 UR - https://www.diw.de/documents/publikationen/73/diw_01.c.829765.de/diw_ssp1071.pdf SN - 2193-5580 VL - 1071 PB - Deutsches Institut für Wirtschaftsforschung (DIW) CY - Berlin ER - TY - THES A1 - Aga-Barfknecht, Heja T1 - Investigation of the phenotype and genetic variant(s) of the diabetes locus Nidd/DBA N2 - Diabetes is a major public health problem with increasing global prevalence. Type 2 diabetes (T2D), which accounts for 90% of all diagnosed cases, is a complex polygenic disease also modulated by epigenetics and lifestyle factors. For the identification of T2D-associated genes, linkage analyses combined with mouse breeding strategies and bioinformatic tools were useful in the past. In a previous study in which a backcross population of the lean and diabetes-prone dilute brown non-agouti (DBA) mouse and the obese and diabetes-susceptible New Zealand obese (NZO) mouse was characterized, a major diabetes quantitative trait locus (QTL) was identified on chromosome 4. The locus was designated non-insulin dependent diabetes from DBA (Nidd/DBA). The aim of this thesis was (i) to perform a detailed phenotypic characterization of the Nidd/DBA mice, (ii) to further narrow the critical region and (iii) to identify the responsible genetic variant(s) of the Nidd/DBA locus. The phenotypic characterization of recombinant congenic mice carrying a 13.6 Mbp Nidd/DBA fragment with 284 genes presented a gradually worsening metabolic phenotype. Nidd/DBA allele carriers exhibited severe hyperglycemia (~19.9 mM) and impaired glucose clearance at 12 weeks of age. Ex vivo perifusion experiments with islets of 13-week-old congenic mice revealed a tendency towards reduced insulin secretion in homozygous DBA mice. In addition, 16-week-old mice showed a severe loss of β-cells and reduced pancreatic insulin content. Pathway analysis of transcriptome data from islets of congenic mice pointed towards a downregulation of cell survival genes. Morphological analysis of pancreatic sections displayed a reduced number of bi-hormonal cells co-expressing glucagon and insulin in homozygous DBA mice, which could indicate a reduced plasticity of endocrine cells in response to hyperglycemic stress. Further generation and phenotyping of recombinant congenic mice enabled the isolation of a 3.3 Mbp fragment that was still able to induce hyperglycemia and contained 61 genes. Bioinformatic analyses including haplotype mapping, sequence and transcriptome analysis were integrated in order to further reduce the number of candidate genes and to identify the presumable causative gene variant. Four putative candidate genes (Ttc39a, Kti12, Osbpl9, Calr4) were defined, which were either differentially expressed or carried a sequence variant. In addition, in silico ChIP-Seq analyses of the 3.3 Mbp region indicated a high number of SNPs located in active regions of binding sites of β-cell transcription factors. This points towards potentially altered cis-regulatory elements that could be responsible for the phenotype conferred by the Nidd/DBA locus. In summary, the Nidd/DBA locus mediates impaired glucose homeostasis and reduced insulin secretion capacity which finally leads to β-cell death. The downregulation of cell survival genes and reduced plasticity of endocrine cells could further contribute to the β-cell loss. The critical region was narrowed down to a 3.3 Mbp fragment containing 61 genes, of which four might be involved in the development of the diabetogenic Nidd/DBA phenotype. N2 - Die Diabetesprävalenz nimmt seit Jahren weltweit zu, wobei etwa 90% der diagnostizierten Diabeteserkrankungen einem Typ-2-Diabetes (T2D) zuzuordnen sind. T2D ist eine komplexe polygene Stoffwechselerkrankung, die auch durch epigenetische Faktoren und den Lebensstil beeinflusst wird. Die Identifizierung und Untersuchung von Diabetes-assoziierten Genen wird unter anderem durch Kopplungsanalysen und darauf aufbauende zuchtstrategische und bioinformatische Analysen ermöglicht. In einer vorangegangenen Studie wurde der schlanke, Diabetes-anfällige dilute brown non-agouti (DBA)-Mausstamm mit der adipösen und ebenfalls Diabetes-suszeptiblen New Zealand obese (NZO)-Maus verpaart und die erste Rückkreuzungsgeneration einer Kopplungsanalyse unterzogen. Hierbei wurde ein hoch signifikanter quantitative trait locus (QTL) für Diabetes auf Chromosom 4 nachgewiesen. Dieser Locus ist mit erhöhten Blutzuckerwerten, reduzierten Plasmainsulinkonzentrationen und einem niedrigen pankreatischen Insulingehalt assoziiert und wurde als Nidd/DBA (engl. für nicht insulinabhängiger Diabetes von DBA-Allelen) bezeichnet. Das Ziel der vorliegenden Arbeit war es, (i) das kritische Fragment des Nidd/DBA-Locus‘ zu verkleinern, (ii) die phänotypische Ausprägung des Nidd/DBA-Locus‘ zu untersuchen sowie (iii) die ursächliche(n) genetische(n) Variante(n) zu identifizieren. Die phänotypische Charakterisierung von kongenen Mäusen mit einem kritischen Fragment von 13.6 Mbp, welches 284 Gene enthält, zeigte bereits im Alter von 12 Wochen eine starke Hyperglykämie (~19.9 mM) und eine unzureichende Glucose-Clearance bei Nidd/DBA-Allelträgern. Ex-vivo Perifusionsversuche mit isolierten Inseln von 13 Wochen alten kongenen Mäusen zeigten eine tendenziell reduzierte Insulinsekretion in homozygoten DBA-Allelträgern. Im Alter von 16 Wochen wiesen die Tiere einen erheblichen Verlust der β-Zellen, sowie eine Abnahme der pankreatischen Insulinkonzentration auf. Transkriptomdaten der Langerhans-Inseln mit anschließender Signalweganalyse deuteten darauf hin, dass Nidd/DBA-Allelträger eine verminderte Expression von Genen aufzeigen, die für das Überleben von Zellen essentiell sind. In homozygoten DBA-Allelträgern wurde eine reduzierte Anzahl von Glucagon/Insulin-bi-hormonellen Zellen nachgewiesen, was auf eine verminderte Plastizität der endokrinen Zellen hinweisen könnte. Die Zucht weiterer kongener Mäuse und ihre Phänotypisierung ermöglichten die Isolierung eines 3.3 Mbp großen Fragments, das 61 Gene enthielt und eine Hyperglykämie auslöste. Bioinformatische Analysen, wie die Kartierung von Haplotypen und Datenbank-, Sequenz- sowie Transkriptomanalysen, wurden integriert, um die Anzahl der Kandidatengene weiter zu reduzieren und die Hyperglykämie auslösende(n) Genvariante(n) zu identifizieren. Es konnten vier potentielle Kandidatengene (Ttc39a, Osbpl9, Kti12, Calr4) definiert werden, die entweder eine differenzielle Expression oder eine Sequenzvariante aufwiesen. Mit Hilfe von in-silico-Analysen von ChIP-Seq-Daten wurden SNPs in aktiven Bindungsstellen von β-Zell-Transkriptionsfaktoren identifiziert. Diese könnten cis-regulatorische Elemente darstellen, die Gene außerhalb dieses 3.3 Mbp großen Fragments beeinflussen und möglichweise für den Phänotyp verantwortlich sind. Zusammenfassend konnte gezeigt werden, dass der Nidd/DBA-Locus für eine beeinträchtigte Glucosehomöostase und eine Verschlechterung der Insulinsekretion verantwortlich ist, welche langfristig zum Verlust von β-Zellen führen. Die bisherigen Ergebnisse deuten darauf hin, dass sowohl die verringerte Expression der für das Zellüberleben essentiellen Gene als auch eine verringerte Plastizität der endokrinen Zellen zum Untergang von Langerhans-Inseln beitragen. Das kritische Fragment wurde auf eine Größe von 3.3 Mbp mit 61 Genen reduziert, von denen vier Gene als verantwortliche Kandidaten für den beschriebenen Nidd/DBA-Phänotyp bedeutsam sein können KW - Diabetes KW - Genetics KW - Glucose intolerance KW - Insulin secretion KW - Susceptibility-genes KW - Diabetes KW - Genetik KW - Glukoseintoleranz KW - Insulinsekretion KW - Suszeptibilitätsgene Y1 - 2021 ER - TY - JOUR A1 - Agrofylax, Sotirios T1 - Rezension zu: Hildebrandt, Annika: Die Mobilisierung der Poesie. Literatur und Krieg um 1750. - Berlin: de Gruyter, 2019. - ISBN 978-3-11-060947-9 JF - Das achtzehnte Jahrhundert : Zeitschrift der Deutschen Gesellschaft für die Erforschung des Achtzehnten Jahrhunderts Y1 - 2021 SN - 0722-740X VL - 45 IS - 2 SP - 310 EP - 312 PB - Wallstein CY - Wolfenbüttel ER - TY - JOUR A1 - Ahmadi, Hamid A1 - Herat, Nehara A1 - Alizadeh, Shahab A1 - Button, Duane C. A1 - Granacher, Urs A1 - Behm, David G. T1 - Effect of an inverted seated position with upper arm blood flow restriction on measures of elbow flexors neuromuscular performance JF - PLOS ONE / Public Library of Science N2 - Purpose The objective of the investigation was to determine the concomitant effects of upper arm blood flow restriction (BFR) and inversion on elbow flexors neuromuscular responses. Methods Randomly allocated, 13 volunteers performed four conditions in a within-subject design: rest (control, 1-min upright position without BFR), control (1-min upright with BFR), 1-min inverted (without BFR), and 1-min inverted with BFR. Evoked and voluntary contractile properties, before, during and after a 30-s maximum voluntary contraction (MVC) exercise intervention were examined as well as pain scale. Results Inversion induced significant pre-exercise intervention decreases in elbow flexors MVC (21.1%, Z2p = 0.48, p = 0.02) and resting evoked twitch forces (29.4%, Z2p = 0.34, p = 0.03). The 30-s MVC induced significantly greater pre- to post-test decreases in potentiated twitch force (Z2p = 0.61, p = 0.0009) during inversion (75%) than upright (65.3%) conditions. Overall, BFR decreased MVC force 4.8% (Z2p = 0.37, p = 0.05). For upright position, BFR induced 21.0% reductions in M-wave amplitude (Z2p = 0.44, p = 0.04). There were no significant differences for electromyographic activity or voluntary activation as measured with the interpolated twitch technique. For all conditions, there was a significant increase in pain scale between the 40-60 s intervals and post-30-s MVC (upright< inversion, and without BFR< BFR). Conclusion The concomitant application of inversion with elbow flexors BFR only amplified neuromuscular performance impairments to a small degree. Individuals who execute forceful contractions when inverted or with BFR should be cognizant that force output may be impaired. Y1 - 2021 U6 - https://doi.org/10.1371/journal.pone.0245311 SN - 1932-6203 VL - 16 IS - 5 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Akarsu, Pinar A1 - Grobe, Richard A1 - Nowaczyk, Julius A1 - Hartlieb, Matthias A1 - Reinicke, Stefan A1 - Böker, Alexander A1 - Sperling, Marcel A1 - Reifarth, Martin T1 - Solid-phase microcontact printing for precise patterning of rough surfaces BT - using polymer-tethered elastomeric stamps for the transfer of reactive silanes JF - ACS applied polymer materials N2 - We present a microcontact printing (mu CP) routine suitable to introduce defined (sub-) microscale patterns on surface substrates exhibiting a high capillary activity and receptive to a silane-based chemistry. This is achieved by transferring functional trivalent alkoxysilanes, such as (3-aminopropyl)-triethoxysilane (APTES) as a low-molecular weight ink via reversible covalent attachment to polymer brushes grafted from elastomeric polydimethylsiloxane (PDMS) stamps. The brushes consist of poly{N-[tris(hydroxymethyl)-methyl]acrylamide} (PTrisAAm) synthesized by reversible addition-fragmentation chain-transfer (RAFT)-polymerization and used for immobilization of the alkoxysilane-based ink by substituting the alkoxy moieties with polymer-bound hydroxyl groups. Upon physical contact of the silane-carrying polymers with surfaces, the conjugated silane transfers to the substrate, thus completely suppressing ink-flow and, in turn, maximizing printing accuracy even for otherwise not addressable substrate topographies. We provide a concisely conducted investigation on polymer brush formation using atomic force microscopy (AFM) and ellipsometry as well as ink immobilization utilizing two-dimensional proton nuclear Overhauser enhancement spectroscopy (H-1-H-1-NOESY-NMR). We analyze the mu CP process by printing onto Si-wafers and show how even distinctively rough surfaces can be addressed, which otherwise represent particularly challenging substrates. KW - microcontact printing KW - capillary-active substrates KW - silane chemistry KW - PDMS surface grafting KW - surface patterning KW - shuttled RAFT-polymerization Y1 - 2021 U6 - https://doi.org/10.1021/acsapm.1c00024 SN - 2637-6105 VL - 3 IS - 5 SP - 2420 EP - 2431 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Alberto, Ibraimo A1 - Schenck, Marcia C. T1 - Paths Are Made by Walking BT - Memories of Being a Mozambican Contract Worker in the GDR JF - Navigating Socialist Encounters Y1 - 2021 SN - 978-3-11-062354-3 SN - 978-3-11-062231-7 U6 - https://doi.org/10.1515/9783110623543-010 SP - 247 EP - 262 PB - de Gruyter CY - Oldenburg ER - TY - THES A1 - Alfine, Eugenia T1 - Investigation of Sirtuin 3 overexpression as a genetic model of fasting in hypothalamic neurons Y1 - 2021 ER - TY - JOUR A1 - Altenberger, Uwe A1 - Cisterna, Clara A1 - Günter, Christina A1 - Gutiérrez, Adolfo Antonio A1 - Rosales, J. T1 - Tectono-metamorphic evolution of the proto-Andean margin of Gondwana BT - Evidence of internal high-grade metamorphism along the northern portion of the Famatinian orogen, Sierra de Aconquija, Sierras Pampeanas Orientales, Argentina JF - Journal of South American earth sciences N2 - The present work gives a detailed analysis of the metamorphic and structural evolution of the back-arc portion of the Famatinian Orogen exposed in the southern Sierra de Aconquija (Cuesta de La Chilca segment) in the Sierras Pampeanas Orientales (Eastern Pampean Sierras). The Pampeanas Orientales include from north to south the Aconquija, Ambato and Ancasti mountains. They are mainly composed of middle to high grade metasedimentary units and magmatic rocks. At the south end of the Sierra de Aconquija, along an east to west segment extending over nearly 10 km (Cuesta de La Chilca), large volumes of metasedimentary rocks crop out. The eastern metasediments were defined as members of the El Portezuelo Metamorphic-Igneous Complex (EPMIC) or Eastern block and the western ones relate to the Quebrada del Molle Metamorphic Complex (QMMC) or Western block. The two blocks are divided by the La Chilca Shear Zone, which is reactivated as the Rio Chanarito fault. The EPMIC, forming the hanging wall, is composed of schists, gneisses and rare amphibolites, calc- silicate schists, marbles and migmatites. The rocks underwent multiple episodes of deformation and a late high strain-rate episode with gradually increasing mylonitization to the west. Metamorphism progrades from a M-1 phase to the peak M-3, characterized by the reactions: Qtz + Pl + Bt +/- Ms -> Grt + Bt(2) + Pl(2) +/- Sil +/- Kfs, Qtz + Bt + Sil -> Crd + Kfs and Qtz + Grt + Sil -> Crd. The M-3 assemblage is coeval with the dominant foliation related to a third deformational phase (D-3). The QMMC, forming the foot wall, is made up of fine-grained banded quartz - biotite schists with quartz veins and quartz-feldspar-rich pegmatites. To the east, schists are also overprinted by mylonitization. The M-3 peak assemblage is quartz + biotite + plagioclase +/- garnet +/- sillimanite +/- muscovite +/- ilmenite +/- magnetite +/- apatite. The studied segment suffered multiphase deformation and metamorphism. Some of these phases can be correlated between both blocks. D-1 is locally preserved in scarce outcrops in the EPMIC but is the dominant in the QMMC, where S-1 is nearly parallel to S-0. In the EPMIC, D-2 is represented by the S-2 foliation, related to the F-2 folding that overprints S-1, with dominant strike NNW - SSE and high angles dip to the E. D-3 in the EPMIC have F-3 folds with axis oblique to S-2; the S-3 foliation has striking NW - SE dipping steeply to the E or W and develops interference patterns. In the QMMC, S-2 (D-2) is a discontinuous cleavage oblique to S-1 and transposed by S-3 (D-3), subparallel to S-1. Such structures in the QMMC developed at subsolidus conditions and could be correlated to those of the EPMIC, which formed under higher P-T conditions. The penetrative deformation D-2 in the EPMIC occurred during a prograde path with syntectonic growth of garnet reaching P-T conditions of 640 degrees C and 0.54 GPa in the EPMIC. This stage was followed by a penetrative deformation D-3 with syn-kinematic growth of garnet, cordierite and plagioclase. Peak P-T conditions calculated for M-3 are 710 degrees C and 0.60 GPa, preserved in the western part of the EPMIC, west of the unnamed fault. The schists from the QMMC suffered the early low grade M-1 metamorphism with minimum PT conditions of ca 400 degrees C and 0.35 GPa, comparable to the fine schists (M-1) outcropping to the east. The D-2 deformation is associated with the prograde M-2 metamorphism. The penetrative D-3 stage is related to a medium grade metamorphism M-3, with peak conditions at ca 590 degrees C and 0.55 GPa. The superimposed stages of deformation and metamorphism reaching high P-T conditions followed by isothermal decompression, defining a clockwise orogenic P-T path. During the Lower Paleozoic, folds were superimposed and recrystallization as well as partial melting at peak conditions occurred. Similar characteristics were described from the basement from other Famatinian-dominated locations of the Sierra de Aconquija and other ranges of the Sierras Pampeanas Orientales. KW - Famatinian KW - Sierras Pampeanas Orientales KW - Cuesta de la chilca KW - PT path Y1 - 2021 U6 - https://doi.org/10.1016/j.jsames.2021.103305 SN - 0895-9811 VL - 110 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Altieri, Riccardo T1 - Rezension zu: Oktoberrevolution 1917 : Ereignis, Rezeption, künstlerische Deutung / Felicitas Fischer von Weikersthal; Tanja Penter; Dorothea Redepenning (Hrsg.). - Heidelberg: Universitätsverlag Winter, 2020. - ISBN: 978-3-8253-6914-9 JF - Zeitschrift für Geschichtswissenschaft : ZfG Y1 - 2021 SN - 0044-2828 VL - 69 IS - 3 SP - 288 EP - 289 PB - Metropol-Verl. CY - Berlin ER - TY - JOUR A1 - Andersson, Edvin K. W. A1 - Sångeland, Christofer A1 - Berggren, Elin A1 - Johansson, Fredrik O. L. A1 - Kühn, Danilo A1 - Lindblad, Andreas A1 - Mindemark, Jonas A1 - Hahlin, Maria T1 - Early-stage decomposition of solid polymer electrolytes in Li-metal batteries JF - Journal of materials chemistry : A, Materials for energy and sustainability N2 - Development of functional and stable solid polymer electrolytes (SPEs) for battery applications is an important step towards both safer batteries and for the realization of lithium-based or anode-less batteries. The interface between the lithium and the solid polymer electrolyte is one of the bottlenecks, where severe degradation is expected. Here, the stability of three different SPEs - poly(ethylene oxide) (PEO), poly(epsilon-caprolactone) (PCL) and poly(trimethylene carbonate) (PTMC) - together with lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) salt, is investigated after they have been exposed to lithium metal under UHV conditions. Degradation compounds, e.g. Li-O-R, LiF and LixSyOz, are identified for all SPEs using soft X-ray photoelectron spectroscopy. A competing degradation between polymer and salt is identified in the outermost surface region (<7 nm), and is dependent on the polymer host. PTMC:LiTFSI shows the most severe decomposition of both polymer and salt followed by PCL:LiTFSI and PEO:LiTFSI. In addition, the movement of lithium species through the decomposed interface shows large variation depending on the polymer electrolyte system. Y1 - 2021 U6 - https://doi.org/10.1039/d1ta05015j SN - 2050-7488 SN - 2050-7496 VL - 9 IS - 39 SP - 22462 EP - 22471 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Andjelković, Marko A1 - Chen, Junchao A1 - Simevski, Aleksandar A1 - Schrape, Oliver A1 - Krstić, Miloš A1 - Kraemer, Rolf T1 - Monitoring of particle count rate and LET variations with pulse stretching inverters JF - IEEE transactions on nuclear science : a publication of the IEEE Nuclear and Plasma Sciences Society N2 - This study investigates the use of pulse stretching (skew-sized) inverters for monitoring the variation of count rate and linear energy transfer (LET) of energetic particles. The basic particle detector is a cascade of two pulse stretching inverters, and the required sensing area is obtained by connecting up to 12 two-inverter cells in parallel and employing the required number of parallel arrays. The incident particles are detected as single-event transients (SETs), whereby the SET count rate denotes the particle count rate, while the SET pulsewidth distribution depicts the LET variations. The advantage of the proposed solution is the possibility to sense the LET variations using fully digital processing logic. SPICE simulations conducted on IHP's 130-nm CMOS technology have shown that the SET pulsewidth varies by approximately 550 ps over the LET range from 1 to 100 MeV center dot cm(2) center dot mg(-1). The proposed detector is intended for triggering the fault-tolerant mechanisms within a self-adaptive multiprocessing system employed in space. It can be implemented as a standalone detector or integrated in the same chip with the target system. KW - Particle detector KW - pulse stretching inverters KW - single-event transient KW - (SET) count rate KW - SET pulsewidth distribution Y1 - 2021 U6 - https://doi.org/10.1109/TNS.2021.3076400 SN - 0018-9499 SN - 1558-1578 VL - 68 IS - 8 SP - 1772 EP - 1781 PB - Institute of Electrical and Electronics Engineers CY - New York, NY ER - TY - JOUR A1 - Andrae, Marianne T1 - Rezension zu: Müller-Engels, Gabriele; Sieghörtner, Robert; Emmerling de Oliveira, Nicole: Adoptionsrecht in der Praxis einschließlich Auslandsbezug. - 4., völlig neu bearbeitete Aufl. - Bielefeld: Gieseking, 2020. - XXVII, 234 S. - ISBN: 978-3-7694-1238-3 JF - Rabels Zeitschrift für ausländisches und internationales Privatrecht = The Rabel journal of comparative and international private law Y1 - 2021 U6 - https://doi.org/10.1628/rabelsz-2021-0016 SN - 0033-7250 SN - 1868-7059 VL - 85 IS - 2 SP - 485 EP - 488 PB - Mohr Siebeck CY - Tübingen ER - TY - JOUR A1 - Andreev, Andrei A1 - Raschke, Elena A1 - Biskaborn, Boris A1 - Vyse, Stuart Andrew A1 - Courtin, Jérémy A1 - Böhmer, Thomas A1 - Stoof-Leichsenring, Kathleen R. A1 - Kruse, Stefan A1 - Pestryakova, Luidmila Agafyevna A1 - Herzschuh, Ulrike T1 - Late Pleistocene to Holocene vegetation and climate changes in northwestern Chukotka (Far East Russia) deduced from lakes Ilirney and Rauchuagytgyn pollen records JF - Boreas : an international journal of quaternary research N2 - This paper presents two new pollen records and quantitative climate reconstructions from northern Chukotka documenting environmental changes over the last 27.9 ka. Open tundra- and steppe-like habitats dominated between 27.9 and 18.7 cal. ka BP. Betula and Alnus shrubs might have grown in sheltered microhabitats but disappeared after 18.7 cal. ka BP. Although the climate was rather harsh, local herb-dominated communities supported herbivores as is evident by the presence of coprophilous spores in the sediments. The increase in Salix and Cyperaceae similar to 16.1 cal. ka BP suggests climate amelioration. Shrub Betula appeared similar to 15.9 cal. ka BP, and became dominant after similar to 15.52 cal. ka BP, whilst typical steppe communities drastically reduced. Very high presence of Botryococcus in the Lateglacial sediments reflects widespread shallow habitats, probably due to lake level increase. Shrub Alnus became common after similar to 13 cal. ka BP reflecting further climate amelioration. Simultaneously, herb communities gradually decreased in the vegetation reaching a minimum similar to 11.8 cal. ka BP. A gradual decrease of algae remains suggests a reduction of shallow-water habitats. Shrubby and graminoid tundra was dominant similar to 11.8-11.1 cal. ka BP, later Salix stands significantly decreased. The forest-tundra ecotone established in the Early Holocene, shortly after 11.1 cal. ka BP. Low contents of green algae in the Early Holocene sediments likely reflect deeper aquatic conditions. The most favourable climate conditions were between similar to 10.6 and 7 cal. ka BP. Vegetation became similar to the modern after similar to 7 cal. ka BP but Pinus pumila came to the Ilirney area at about 1.2 cal. ka BP. It is important to emphasize that the study area provided refugia for Betula and Alnus during MIS 2. It is also notable that our records do not reflect evidence of Younger Dryas cooling, which is inconsistent with some regional environmental records but in good accordance with some others. Y1 - 2021 U6 - https://doi.org/10.1111/bor.12521 SN - 0300-9483 SN - 1502-3885 VL - 50 IS - 3 SP - 652 EP - 670 PB - Wiley-Blackwell CY - Oxford [u.a.] ER - TY - THES A1 - Andres, Hannah T1 - Karl Peters (1904–1998) BT - Verantwortung und Anspruch eines Juristen T2 - Rechtshistorische Reihe N2 - Dieses Buch zeichnet das Leben und Wirken des bedeutenden Strafrechtswissenschaftlers Karl Peters nach, wobei ein Schwerpunkt auf der Zeit des Nationalsozialismus liegt. Als Staatsanwalt seit 1932 tätig, auf Grund seiner katholischen Konfession erst 1942 zum Ordinarius in Greifswald ernannt, von 1946 bis 1962 Professor in Münster und sodann bis 1972 in Tübingen tätig. Peters‘ Wirken beeindruckt durch seine Bandbreite. Neben einer intensiven Auseinandersetzung mit dem Strafprozess, -vollzugs- und Jugendstrafrecht forschte er in den Bereichen dermKriminologie, Soziologie, Psychologie, Medizin und Pädagogik. Getragen von christlichen Grundanschauungen stellte Peters hohe Anforderungen an sich und den (Straf-)Juristen. Die Beschäftigung mit Justizirrtümern und dem Wiederaufnahmeverfahrensrecht wurde zu seinem Hauptanliegen. Y1 - 2021 SN - 978-3-631-87190-4 SN - 978-3-631-85384-9 SN - 978-3-631-87288-8 SN - 978-3-631-87287-1 U6 - https://doi.org/10.3726/b19403 SN - 0344-290X IS - 496 PB - Peter Lang GmbH CY - Frankfurt, M. ; Berlin ; Bern ; Bruxelles ; New York, NY ; Oxford ; Wien ER - TY - JOUR A1 - Andres, Lesley A1 - Lauterbach, Wolfgang A1 - Jongbloed, Janine A1 - Hümme, Hartwig T1 - Gender, education, and labour market participation across the life course BT - a Canada/Germany comparison JF - International journal of lifelong education N2 - In this paper, we employ a comparative life course approach for Canada and Germany to unravel the relationships among general and vocational educational attainment and different life course activities, with a focus on labour market and income inequality by gender. Life course theory and related concepts of 'time,' 'normative patterns,' 'order and disorder,' and 'discontinuities' are used to inform the analyses. Data from the Paths on Life's Way (Paths) project in British Columbia, Canada and the German Pathways from Late Childhood to Adulthood (LifE) which span 28 and 33 years, respectively, are employed to examine life trajectories from leaving school to around age 45. Sequence analysis and cluster analyses portray both within and between country differences - and in particular gender differences - in educational attainment, employment, and other activities across the life course which has an impact on ultimate labour market participation and income levels. 'Normative' life courses that follow a traditional order correspond with higher levels of full-time work and higher incomes; in Germany more so than Canada, these clusters are male dominated. Clusters characterised by 'disordered' and 'discontinuous' life courses in both countries are female dominated and associated with lower income levels. KW - Comparative life course trajectories KW - education KW - gender KW - work KW - income KW - labour market inequality Y1 - 2021 U6 - https://doi.org/10.1080/02601370.2021.1924302 SN - 0260-1370 SN - 1464-519X VL - 40 IS - 2 SP - 170 EP - 189 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Andres, Maximilian A1 - Bruttel, Lisa A1 - Friedrichsen, Jana T1 - The leniency rule revisited BT - experiments on cartel formation with open communication JF - International journal of industrial organization N2 - The experimental literature on antitrust enforcement provides robust evidence that communication plays an important role for the formation and stability of cartels. We extend these studies through a design that distinguishes between innocuous communication and communication about a cartel, sanctioning only the latter. To this aim, we introduce a participant in the role of the competition authority, who is properly incentivized to judge the communication content and price setting behavior of the firms. Using this novel design, we revisit the question whether a leniency rule successfully destabilizes cartels. In contrast to existing experimental studies, we find that a leniency rule does not affect cartelization. We discuss potential explanations for this contrasting result. KW - cartel KW - judgment of communication KW - corporate leniency program KW - price competition KW - experiment Y1 - 2021 U6 - https://doi.org/10.1016/j.ijindorg.2021.102728 SN - 0167-7187 VL - 76 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Angeleska, Angela A1 - Omranian, Sara A1 - Nikoloski, Zoran T1 - Coherent network partitions BT - Characterizations with cographs and prime graphs JF - Theoretical computer science : the journal of the EATCS N2 - We continue to study coherent partitions of graphs whereby the vertex set is partitioned into subsets that induce biclique spanned subgraphs. The problem of identifying the minimum number of edges to obtain biclique spanned connected components (CNP), called the coherence number, is NP-hard even on bipartite graphs. Here, we propose a graph transformation geared towards obtaining an O (log n)-approximation algorithm for the CNP on a bipartite graph with n vertices. The transformation is inspired by a new characterization of biclique spanned subgraphs. In addition, we study coherent partitions on prime graphs, and show that finding coherent partitions reduces to the problem of finding coherent partitions in a prime graph. Therefore, these results provide future directions for approximation algorithms for the coherence number of a given graph. KW - Graph partitions KW - Network clustering KW - Cographs KW - Coherent partition KW - Prime graphs Y1 - 2021 U6 - https://doi.org/10.1016/j.tcs.2021.10.002 SN - 0304-3975 VL - 894 SP - 3 EP - 11 PB - Elsevier CY - Amsterdam [u.a.] ER - TY - JOUR A1 - Angerer, Marie-Luise T1 - Theoretische und poitische Elemente eines affektiven Gefüges JF - Politik der Emotionen/Macht der Affekte Y1 - 2021 SN - 978-3-0358-0419-5 SP - 99 EP - 110 PB - Diaphanes CY - Zürich ER - TY - BOOK A1 - Apelojg, Benjamin A1 - Holzendorf, Ulf A1 - Meier, Bernd A1 - Mette, Dieter T1 - Startklar! - Wirtschaft, Arbeit, Technik BT - Teil: [Schülerbuch] Y1 - 2021 SN - 978-3-637-01960-7 SN - 978-3-637-01961-4 PB - Oldenbourg Schulbuchverlag CY - München ET - 1. Aufl., 4.Druck. ER - TY - JOUR A1 - Apelt, Maja A1 - Binder, Beate A1 - Kuster, Friederike T1 - Einleitung JF - Feministische Studien Y1 - 2021 U6 - https://doi.org/10.1515/fs-2021-0027 SN - 0723-5186 VL - 39 IS - 2 SP - 197 EP - 201 PB - De Gruyter Oldenbourg CY - Berlin ER - TY - JOUR A1 - Apriyanto, Ardha A1 - Tambunan, Van Basten T1 - Draft genome sequence, annotation, and SSR mining data of Elaeidobius kamerunicus Faust., an essential oil palm pollinating weevil JF - Data in Brief N2 - Elaeidobius kamerunicus Faust. (Coleoptera: Curculionidae) is an essential insect pollinator in oil palm plantations. Recently, researches have been undertaken to improve pollination efficiency using this species. A fundamental understanding of the genes related to this pollinator behavior is necessary to achieve this goal. Here, we present the draft genome sequence, annotation, and simple sequence repeat (SSR) marker data for this pollinator. In total, 34.97 Gb of sequence data from one male individual (monoisolate) were obtained using Illumina short-read platform NextSeq 500. The draft genome assembly was found to be 269.79 Mb and about 59.9% of completeness based on Benchmarking Universal Single-Copy Orthologs (BUSCO) assessment. Functional gene annotation predicted about 26.566 genes. Also, a total of 281.668 putative SSR markers were identified. This draft genome sequence is a valuable resource for understanding the population genetics, phylogenetics, dispersal patterns, and behavior of this species. KW - Whole-genome sequencing KW - NGS KW - Simple Sequence Repeat KW - Weevil KW - Curculionidae KW - Oil Palm KW - Pollinator KW - Genomics Y1 - 2021 U6 - https://doi.org/10.1016/j.dib.2021.106745 SN - 2352-3409 VL - 34 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Asche, Matthias T1 - Von der Provinz in die Metropole BT - die Kinder- und Jugendjahre der Königin Luise JF - Berliner Geschichte - Zeitschrift für Geschichte und Kultur : Königin Luise N2 - Der Artikel beschäftigt sich dezidiert mit der Herkunft der Königin Luise und widmet sich neben dynastischen Verflechtungen auch ihren Kinder- und Jugendjahren. KW - Königin Luise KW - Queen Luise KW - Mecklenburg-Strelitz KW - Mecklenburg-Strelitz Y1 - 2021 SN - 978-3-96201-062-1 SN - 2364-3080 IS - 25 SP - 7 EP - 17 PB - Elsengold CY - Berlin ER - TY - JOUR A1 - Asche, Matthias A1 - Czech, Vinzenz A1 - Göse, Frank A1 - Neitmann, Klaus ED - Asche, Matthias ED - Czech, Vinzenz ED - Göse, Frank ED - Neitmann, Klaus T1 - Zur Einführung JF - Brandenburgische Erinnerungsorte – Erinnerungsorte in Brandenburg, Bd. 1 (= Einzelveröffentlichungen der Brandenburgischen Historischen Kommission e.V. 24) KW - Erinnerungsorte Y1 - 2021 SN - 978-3-95410-294-5 SP - 7 EP - 13 PB - be.bra wissenschaft verlag CY - Berlin ER - TY - JOUR A1 - Asche, Matthias A1 - Gerber, Stefan T1 - Universität JF - Historische Bildungsforschung. Konzepte - Methoden - Forschungsfelder KW - Universitätsgeschichte Y1 - 2021 SN - 978-3-8252-5563-3 SN - 978-3-8385-5563-8 SP - 299 EP - 312 PB - Klinkhardt CY - Bad Heilbrunn ER - TY - JOUR A1 - Asche, Matthias A1 - Schindling, Anton T1 - Konfessionspolitik und Religionsfrieden BT - das Heilige Römische Reich, seine Territorien und Städte sowie die mittel- und ostmitteleuropäischen Nachbarstaaten JF - Vom ein- zum mehrkonfessionellen Landesstaat – die Religionsfrage in den brandenburgisch-preußischen Territorien vom 16. bis zum frühen 18. Jahrhundert (= Forschungen zur Brandenburgischen und Preußischen Geschichte. Neue Folge. Beihefte 16) KW - Religionsfrieden KW - Konfessionspolitik Y1 - 2021 SN - 978-3-428-18174-2 IS - 16 SP - 15 EP - 40 PB - Duncker & Humblot CY - Berlin ER - TY - JOUR A1 - Astudillo-Sotomayor, Luis A1 - Jara Muñoz, Julius A1 - Melnick, Daniel A1 - Cortés‐Aranda, Joaquín A1 - Tassara, Andrés A1 - Strecker, Manfred T1 - Fast Holocene slip and localized strain along the Liquiñe-Ofqui strike-slip fault system, Chile JF - Scientific reports N2 - In active tectonic settings dominated by strike-slip kinematics, slip partitioning across subparallel faults is a common feature; therefore, assessing the degree of partitioning and strain localization is paramount for seismic hazard assessments. Here, we estimate a slip rate of 18.8 +/- 2.0 mm/year over the past 9.0 +/- 0.1 ka for a single strand of the Liquirie-Ofqui Fault System, which straddles the Main Cordillera in Southern Chile. This Holocene rate accounts for similar to 82% of the trench-parallel component of oblique plate convergence and is similar to million-year estimates integrated over the entire fault system. Our results imply that strain localizes on a single fault at millennial time scale but over longer time scales strain localization is not sustained. The fast millennial slip rate in the absence of historical Mw> 6.5 earthquakes along the Liquine-Ofqui Fault System implies either a component of aseismic slip or Mw similar to 7 earthquakes involving multi-trace ruptures and > 150-year repeat times. Our results have implications for the understanding of strike-slip fault system dynamics within volcanic arcs and seismic hazard assessments. KW - Geodynamics KW - Geomorphology KW - Tectonics Y1 - 2021 U6 - https://doi.org/10.1038/s41598-021-85036-5 SN - 2045-2322 VL - 11 IS - 1 PB - Macmillan Publishers Limited, part of Springer Nature CY - London ER - TY - JOUR A1 - Auer, Cornelia A1 - Kriegler, Elmar A1 - Carlsen, Henrik A1 - Kok, Kasper A1 - Pedde, Simona A1 - Krey, Volker A1 - Müller, Boris T1 - Climate change scenario services BT - from science to facilitating action JF - One earth N2 - The goal of limiting global warming to well below 2°C as set out in the Paris Agreement calls for a strategic assessment of societal pathways and policy strategies. Besides policy makers, new powerful actors from the private sector, including finance, have stepped up to engage in forward-looking assessments of a Paris-compliant and climate-resilient future. Climate change scenarios have addressed this demand by providing scientific insights on the possible pathways ahead to limit warming in line with the Paris climate goal. Despite the increased interest, the potential of climate change scenarios has not been fully unleashed, mostly due to a lack of an intermediary service that provides guidance and access to climate change scenarios. This perspective presents the concept of a climate change scenario service, its components, and a prototypical implementation to overcome this shortcoming aiming to make scenarios accessible to a broader audience of societal actors and decision makers. KW - climate change scenarios KW - climate change scenario services KW - climate services KW - co-production KW - visualization KW - capacity building KW - mitigation scenarios KW - adaptation scenarios KW - impact projections Y1 - 2021 U6 - https://doi.org/10.1016/j.oneear.2021.07.015 SN - 2590-3322 SN - 2590-3330 VL - 4 IS - 8 SP - 1074 EP - 1082 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Ayanbayev, Birzhan A1 - Klebanov, Ilja A1 - Li, Han Cheng A1 - Sullivan, Tim J. T1 - Gamma-convergence of Onsager-Machlup functionals BT - I. With applications to maximum a posteriori estimation in Bayesian inverse problems JF - Inverse problems : an international journal of inverse problems, inverse methods and computerised inversion of data N2 - The Bayesian solution to a statistical inverse problem can be summarised by a mode of the posterior distribution, i.e. a maximum a posteriori (MAP) estimator. The MAP estimator essentially coincides with the (regularised) variational solution to the inverse problem, seen as minimisation of the Onsager-Machlup (OM) functional of the posterior measure. An open problem in the stability analysis of inverse problems is to establish a relationship between the convergence properties of solutions obtained by the variational approach and by the Bayesian approach. To address this problem, we propose a general convergence theory for modes that is based on the Gamma-convergence of OM functionals, and apply this theory to Bayesian inverse problems with Gaussian and edge-preserving Besov priors. Part II of this paper considers more general prior distributions. KW - Bayesian inverse problems KW - Gamma-convergence KW - maximum a posteriori KW - estimation KW - Onsager-Machlup functional KW - small ball probabilities; KW - transition path theory Y1 - 2021 U6 - https://doi.org/10.1088/1361-6420/ac3f81 SN - 0266-5611 SN - 1361-6420 VL - 38 IS - 2 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Ayanbayev, Birzhan A1 - Klebanov, Ilja A1 - Lie, Han Cheng A1 - Sullivan, Tim J. T1 - Gamma-convergence of Onsager-Machlup functionals BT - II. Infinite product measures on Banach spaces JF - Inverse problems : an international journal of inverse problems, inverse methods and computerised inversion of data N2 - We derive Onsager-Machlup functionals for countable product measures on weighted l(p) subspaces of the sequence space R-N. Each measure in the product is a shifted and scaled copy of a reference probability measure on R that admits a sufficiently regular Lebesgue density. We study the equicoercivity and Gamma-convergence of sequences of Onsager-Machlup functionals associated to convergent sequences of measures within this class. We use these results to establish analogous results for probability measures on separable Banach or Hilbert spaces, including Gaussian, Cauchy, and Besov measures with summability parameter 1 <= p <= 2. Together with part I of this paper, this provides a basis for analysis of the convergence of maximum a posteriori estimators in Bayesian inverse problems and most likely paths in transition path theory. KW - Bayesian inverse problems KW - Gamma-convergence KW - maximum a posteriori KW - estimation KW - Onsager-Machlup functional KW - small ball probabilities KW - transition path theory Y1 - 2021 U6 - https://doi.org/10.1088/1361-6420/ac3f82 SN - 0266-5611 SN - 1361-6420 VL - 38 IS - 2 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Ayzel, Georgy T1 - Deep neural networks in hydrology BT - the new generation of universal and efficient models BT - новое поколение универсальных и эффективных моделей JF - Vestnik of Saint Petersburg University. Earth Sciences N2 - For around a decade, deep learning - the sub-field of machine learning that refers to artificial neural networks comprised of many computational layers - modifies the landscape of statistical model development in many research areas, such as image classification, machine translation, and speech recognition. Geoscientific disciplines in general and the field of hydrology in particular, also do not stand aside from this movement. Recently, the proliferation of modern deep learning-based techniques and methods has been actively gaining popularity for solving a wide range of hydrological problems: modeling and forecasting of river runoff, hydrological model parameters regionalization, assessment of available water resources. identification of the main drivers of the recent change in water balance components. This growing popularity of deep neural networks is primarily due to their high universality and efficiency. The presented qualities, together with the rapidly growing amount of accumulated environmental information, as well as increasing availability of computing facilities and resources, allow us to speak about deep neural networks as a new generation of mathematical models designed to, if not to replace existing solutions, but significantly enrich the field of geophysical processes modeling. This paper provides a brief overview of the current state of the field of development and application of deep neural networks in hydrology. Also in the following study, the qualitative long-term forecast regarding the development of deep learning technology for managing the corresponding hydrological modeling challenges is provided based on the use of "Gartner Hype Curve", which in the general details describes a life cycle of modern technologies. N2 - В течение последнего десятилетия глубокое обучение - область машинного обучения, относящаяся к искусственным нейронным сетям, состоящим из множества вычислительных слоев, - изменяет ландшафт развития статистических моделей во многих областях исследований, таких как классификация изображений, машинный перевод, распознавание речи. Географические науки, а также входящая в их состав область исследования гидрологии суши, не стоят в стороне от этого движения. В последнее время применение современных технологий и методов глубокого обучения активно набирает популярность для решения широкого спектра гидрологических задач: моделирования и прогнозирования речного стока, районирования модельных параметров, оценки располагаемых водных ресурсов, идентификации факторов, влияющих на современные изменения водного режима. Такой рост популярности глубоких нейронных сетей продиктован прежде всего их высокой универсальностью и эффективностью. Представленные качества в совокупности с быстрорастущим количеством накопленной информации о состоянии окружающей среды, а также ростом доступности вычислительных средств и ресурсов, позволяют говорить о глубоких нейронных сетях как о новом поколении математических моделей, призванных если не заменить существующие решения, то значительно обогатить область моделирования геофизических процессов. В данной работе представлен краткий обзор текущего состояния области разработки и применения глубоких нейронных сетей в гидрологии. Также в работе предложен качественный долгосрочный прогноз развития технологии глубокого обучения для решения задач гидрологического моделирования на основе использования «кривой ажиотажа Гартнера», в общих чертах описывающей жизненный цикл современных технологий. T2 - Глубокие нейронные сети в гидрологии KW - deep neural networks KW - deep learning KW - machine learning KW - hydrology KW - modeling KW - глубокие нейронные сети KW - глубокое обучение KW - машинное обучение KW - гидрология KW - моделирование Y1 - 2021 U6 - https://doi.org/10.21638/spbu07.2021.101 SN - 2541-9668 SN - 2587-585X VL - 66 IS - 1 SP - 5 EP - 18 PB - Univ. Press CY - St. Petersburg ER - TY - JOUR A1 - Ayzel, Georgy A1 - Heistermann, Maik T1 - The effect of calibration data length on the performance of a conceptual hydrological model versus LSTM and GRU BT - a case study for six basins from the CAMELS dataset JF - Computers & geosciences : an international journal devoted to the publication of papers on all aspects of geocomputation and to the distribution of computer programs and test data sets ; an official journal of the International Association for Mathematical Geology N2 - We systematically explore the effect of calibration data length on the performance of a conceptual hydrological model, GR4H, in comparison to two Artificial Neural Network (ANN) architectures: Long Short-Term Memory Networks (LSTM) and Gated Recurrent Units (GRU), which have just recently been introduced to the field of hydrology. We implemented a case study for six river basins across the contiguous United States, with 25 years of meteorological and discharge data. Nine years were reserved for independent validation; two years were used as a warm-up period, one year for each of the calibration and validation periods, respectively; from the remaining 14 years, we sampled increasing amounts of data for model calibration, and found pronounced differences in model performance. While GR4H required less data to converge, LSTM and GRU caught up at a remarkable rate, considering their number of parameters. Also, LSTM and GRU exhibited the higher calibration instability in comparison to GR4H. These findings confirm the potential of modern deep-learning architectures in rainfall runoff modelling, but also highlight the noticeable differences between them in regard to the effect of calibration data length. KW - Artificial neural networks KW - Calibration KW - Deep learning KW - Rainfall-runoff KW - modelling Y1 - 2021 U6 - https://doi.org/10.1016/j.cageo.2021.104708 SN - 0098-3004 SN - 1873-7803 VL - 149 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Baccini, Leonardo A1 - Heinzel, Mirko A1 - Koenig-Archibugi, Mathias T1 - The social construction of global health priorities BT - an empirical analysis of contagion in bilateral health aid JF - International studies quarterly N2 - Donors of development assistance for health typically provide funding for a range of disease focus areas, such as maternal health and child health, malaria, HIV/AIDS, and other infectious diseases. But funding for each disease category does not match closely its contribution to the disability and loss of life it causes and the cost-effectiveness of interventions. We argue that peer influences in the social construction of global health priorities contribute to explaining this misalignment. Aid policy-makers are embedded in a social environment encompassing other donors, health experts, advocacy groups, and international officials. This social environment influences the conceptual and normative frameworks of decision-makers, which in turn affect their funding priorities. Aid policy-makers are especially likely to emulate decisions on funding priorities taken by peers with whom they are most closely involved in the context of expert and advocacy networks. We draw on novel data on donor connectivity through health IGOs and health INGOs and assess the argument by applying spatial regression models to health aid disbursed globally between 1990 and 2017. The analysis provides strong empirical support for our argument that the involvement in overlapping expert and advocacy networks shapes funding priorities regarding disease categories and recipient countries in health aid. Y1 - 2021 U6 - https://doi.org/10.1093/isq/sqab092 SN - 0020-8833 SN - 1468-2478 VL - 66 IS - 1 PB - Oxford University Press CY - Oxford ER - TY - THES A1 - Bacskai-Atkari, Julia T1 - The syntax of functional left peripheries BT - clause typing in west germanic and beyond Y1 - 2021 ER - TY - JOUR A1 - Bade, Nadine T1 - On the scope and nature of Maximise Presupposition JF - Language and linguistics compass N2 - The paper introduces the principle Maximise Presupposition and its cognates. The main focus of the literature and this article is on the inferences that arise as a result of reasoning with Maximise Presupposition ('anti-presuppositions'). I will review the arguments put forward for distinguishing them from other inference types, most notably presuppositions and conversational implicatures. I will zoom in on three main issues regarding Maximise Presupposition and these inferences critically discussed in the literature: epistemic strength(ening), projection, and the role of alternatives. I will discuss more recent views which argue for either a uniform treatment of anti-presuppositions and implicatures and/or a revision of the original principle in light of new data and developments in pragmatics. Y1 - 2021 U6 - https://doi.org/10.1111/lnc3.12416 SN - 1749-818X VL - 15 IS - 6 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Baert, By Stijn A1 - Neyt, Brecht A1 - Siedler, Thomas A1 - Tobback, Ilse A1 - Verhaest, Dieter T1 - Student internships and employment opportunities after graduation BT - a field experiment JF - Economics of education review N2 - Internships during tertiary education have become substantially more common over the past decades in many industrialised countries. This study examines the impact of a voluntary intra-curricular internship experience during university studies on the probability of being invited to a job interview. To estimate a causal relationship, we conducted a randomised field experiment in which we sent 1248 fictitious, but realistic, resumes to real job openings. We find that applicants with internship experience have, on average, a 12.6% higher probability of being invited to a job interview. KW - internship KW - hiring KW - field experiment KW - human capital KW - signalling Y1 - 2021 U6 - https://doi.org/10.1016/j.econedurev.2021.102141 SN - 0272-7757 VL - 83 PB - Elsevier CY - Oxford ER - TY - THES A1 - Baeseler, Jessica T1 - Trace element effects on longevity and neurodegeneration with focus on C. elegans T1 - Effekte von Spurenelementen auf die Lebensdauer und Neurodegeneration mit Fokus auf C. elegans N2 - The trace elements zinc and manganese are essential for human health, especially due to their enzymatic and protein stabilizing functions. If these elements are ingested in amounts exceeding the requirements, regulatory processes for maintaining their physiological concentrations (homeostasis) can be disturbed. Those homeostatic dysregulations can cause severe health effects including the emergence of neurodegenerative disorders such as Parkinson’s disease (PD). The concentrations of essential trace elements also change during the aging process. However, the relations of cause and consequence between increased manganese and zinc uptake and its influence on the aging process and the emergence of the aging-associated PD are still rarely understood. This doctoral thesis therefore aimed to investigate the influence of a nutritive zinc and/or manganese oversupply on the metal homeostasis during the aging process. For that, the model organism Caenorhabditis elegans (C. elegans) was applied. This nematode suits well as an aging and PD model due to properties such as its short life cycle and its completely sequenced, genetically amenable genome. Different protocols for the propagation of zinc- and/or manganese-supplemented young, middle-aged and aged C. elegans were established. Therefore, wildtypes, as well as genetically modified worm strains modeling inheritable forms of parkinsonism were applied. To identify homeostatic and neurological alterations, the nematodes were investigated with different methods including the analysis of total metal contents via inductively-coupled plasma tandem mass spectrometry, a specific probe-based method for quantifying labile zinc, survival assays, gene expression analysis as well as fluorescence microscopy for the identification and quantification of dopaminergic neurodegeneration.. During aging, the levels of iron, as well as zinc and manganese increased.. Furthermore, the simultaneous oversupply with zinc and manganese increased the total zinc and manganese contents to a higher extend than the single metal supplementation. In this relation the C. elegans metallothionein 1 (MTL-1) was identified as an important regulator of metal homeostasis. The total zinc content and the concentration of labile zinc were age-dependently, but differently regulated. This elucidates the importance of distinguishing these parameters as two independent biomarkers for the zinc status. Not the metal oversupply, but aging increased the levels of dopaminergic neurodegeneration. Additionally, nearly all these results yielded differences in the aging-dependent regulation of trace element homeostasis between wildtypes and PD models. This confirms that an increased zinc and manganese intake can influence the aging process as well as parkinsonism by altering homeostasis although the underlying mechanisms need to be clarified in further studies. N2 - Die Spurenelemente Zink und Mangan sind vor allem aufgrund ihrer enzymatischen und Protein-stabilisierenden Funktionen essentiell für die menschliche Gesundheit. Werden sie allerdings in Mengen aufgenommen, die den Bedarf übersteigen, können regulatorische Prozesse für die Aufrechterhaltung physiologischer Konzentrationen dieser Metalle (Homöostase) aus dem Gleichgewicht geraten. Das kann ernsthafte gesundheitliche Konsequenzen nach sich ziehen, unter anderem die Entstehung neurodegenerativer Krankheiten, wie zum Beispiel der Parkinson’schen Erkrankung. Auch während des Alterungsprozesses verändern sich die Gehalte an lebensnotwendigen Spurenelementen im Körper. Jedoch sind die Zusammenhänge zwischen Ursache und Wirkung einer erhöhten Aufnahme an Zink und Mangan und deren Einfluss auf den Alterungsprozess und die Entstehung der altersassoziierten Parkinson’schen Erkrankung bisher nur unzureichend verstanden. Im Rahmen dieser Doktorarbeit wurde deshalb der Einfluss einer nutritiven Zink- und/oder Manganüberversorgung auf die Metallhomöostase während der Alterung untersucht. Dazu wurde Caenorhabditis elegans (C. elegans) als Modellorganismus verwendet. Diese Fadenwürmer eignen sich aufgrund verschiedener Eigenschaften, wie einem kurzen Lebenszyklus und einem komplett sequenzierten und leicht manipulierbarem Genom, hervorragend als Alters- und Parkinson-Modelle. Es wurden verschiedene Protokolle etabliert, die die Anzucht von Zink- und/oder Mangan-supplementierten jungen, mittelalten bzw. gealterten C. elegans erlaubten. Neben Wildtypen wurden auch Wurmstämme untersucht, die genetische Modifikationen aufweisen, die mit vererbbaren Formen des Parkinsonismus assoziiert werden können. Die Würmer wurden mithilfe verschiedener Methoden, wie der analytischen Bestimmung des Gesamtmetallgehaltes mittels Massenspektrometrie mit induktiv-gekoppeltem Plasma, einer Sonden-spezifischen Methode zur Bestimmung von freiem Zink, Letalitätsassays, Genexpressionsanalysen und der Fluoreszenz-mikroskopischen Untersuchung der dopaminergen Neurodegeneration auf verschiedene Parameter untersucht, die Aufschluss über homöostatische und neurologische Veränderungen geben. Es wurde eine altersbedingte Zunahme von Eisen, sowie Zink und Mangan in den Würmern beobachtet. Weiterhin stellte sich heraus, dass vor allem die simultane Überversorgung mit Zink und Mangan den Gesamtmetallgehalt dieser Metalle in C. elegans in einem Maß steigerte, das das der Einzelmetallsupplementierung überstieg. Dabei konnte vor allem das C. elegans Metallothionein 1 (MTL-1) als wichtiger Faktor in der Regulation der Metallhomöostase identifiziert werden. Außerdem wurde die Wichtigkeit verdeutlicht, zwischen dem Gesamtzinkgehalt und der Konzentration an freiem Zink als Biomarkern für den Zinkstatus eines Organismus zu unterscheiden. Beide Parameter wurden altersabhängig unterschiedlich reguliert. Im Gegensatz zur Alterung, wurde durch die Überversorgung mit Metallen keine zusätzliche Schädigung der dopaminergen Neuronen beobachtet. In nahezu all diesen Ergebnissen verdeutlichten sich weiterhin Unterschiede in der altersabhängigen Regulation der Spurenelementhomöostase zwischen Wildtypen und Parkinson-Modellen. Dies bestätigt die Annahme, dass sich eine erhöhte Aufnahme von Mangan und Zink durch die Beeinflussung der Homöostase sowohl auf die Alterung, als auch den Parkinsonismus auswirken kann, jedoch müssen die mechanistischen Grundlagen dessen in zukünftigen Studien aufgeklärt werden. KW - Caenorhabditis elegans KW - aging KW - trace element KW - zinc KW - manganese KW - Caenorhabditis elegans KW - Alterung KW - Spurenelement KW - Zink KW - Mangan Y1 - 2021 ER - TY - JOUR A1 - Baesler, Jessica A1 - Michaelis, Vivien A1 - Stiboller, Michael A1 - Haase, Hajo A1 - Aschner, Michael A1 - Schwerdtle, Tanja A1 - Sturzenbaum, Stephen R. A1 - Bornhorst, Julia T1 - Nutritive manganese and zinc overdosing in aging c. elegans result in a metallothionein-mediated alteration in metal homeostasis JF - Molecular Nutrition and Food Research N2 - Manganese (Mn) and zinc (Zn) are not only essential trace elements, but also potential exogenous risk factors for various diseases. Since the disturbed homeostasis of single metals can result in detrimental health effects, concerns have emerged regarding the consequences of excessive exposures to multiple metals, either via nutritional supplementation or parenteral nutrition. This study focuses on Mn-Zn-interactions in the nematode Caenorhabditis elegans (C. elegans) model, taking into account aspects related to aging and age-dependent neurodegeneration. KW - aging KW - C. elegans KW - homeostasis KW - manganese KW - zinc Y1 - 2021 U6 - https://doi.org/10.1002/mnfr.202001176 SN - 1613-4133 SN - 1613-4125 VL - 65 IS - 8 SP - 1 EP - 11 PB - Wiley-VCH GmbH CY - Weinheim ER - TY - JOUR A1 - Baldenius, Till A1 - Bernstein, Tobias A1 - Kalkuhl, Matthias A1 - von Kleist-Retzow, Maximilian A1 - Koch, Nicolas T1 - Ordnungsrecht oder Preisinstrumente? BT - zur Verteilungswirkung von Klimaschutzmaßnahmen im Verkehr JF - Ifo-Schnelldienst Y1 - 2021 UR - https://www.ifo.de/DocDL/sd-2021-06-loeschel-etal-klimapolitik-verteilungswirkungen.pdf#page=4 SN - 0018-974X SN - 2700-8371 SN - 2199-4455 VL - 74 IS - 6 SP - 6 EP - 10 PB - Institut für Wirtschaftsforschung CY - München ER -