TY - JOUR A1 - Esfahani, Reza Dokht Dolatabadi A1 - Gholami, Ali A1 - Ohrnberger, Matthias T1 - An inexact augmented Lagrangian method for nonlinear dispersion-curve inversion using Dix-type global linear approximation JF - Geophysics : a journal of general and applied geophysics N2 - Dispersion-curve inversion of Rayleigh waves to infer subsurface shear-wave velocity is a long-standing problem in seismology. Due to nonlinearity and ill-posedness, sophisticated regularization techniques are required to solve the problem for a stable velocity model. We have formulated the problem as a minimization problem with nonlinear operator constraint and then solve it by using an inexact augmented Lagrangian method, taking advantage of the Haney-Tsai Dix-type relation (a global linear approximation of the nonlinear forward operator). This replaces the original regularized nonlinear problem with iterative minimization of a more tractable regularized linear problem followed by a nonlinear update of the phase velocity (data) in which the update can be performed accurately with any forward modeling engine, for example, the finite-element method. The algorithm allows discretizing the medium with thin layers (for the finite-element method) and thus omitting the layer thicknesses from the unknowns and also allows incorporating arbitrary regularizations to shape the desired velocity model. In this research, we use total variation regularization to retrieve the shear-wave velocity model. We use two synthetic and two real data examples to illustrate the performance of the inversion algorithm with total variation regularization. We find that the method is fast and stable, and it converges to the solution of the original nonlinear problem. KW - surface wave KW - nonlinear KW - inversion KW - modeling KW - finite element Y1 - 2020 U6 - https://doi.org/10.1190/geo2019-0717.1 SN - 0016-8033 SN - 1942-2156 VL - 85 IS - 3 SP - EN77 EP - EN85 PB - GeoScienceWorld CY - Tulsa, Okla. ER - TY - GEN A1 - Jasser, Greta A1 - Kelly, Megan A1 - Rothermel, Ann-Kathrin T1 - Male supremacism and the Hanau terrorist attack BT - between online misogyny and far-right violence Y1 - 2020 UR - https://www.icct.nl/publication/male-supremacism-and-hanau-terrorist-attack-between-online-misogyny-and-far-right PB - International Centre for Counter-Terrorism (ICCT) CY - Den Haag ER - TY - CHAP A1 - Wagner, Dieter A1 - Tellez, Ibrahin Amhed León ED - Hickmann, Thomas ED - Lederer, Markus T1 - Knowledge and technology-transfer-networks BT - examples in the nutrition, food and agricultural sector in Germany and Cuba T2 - Leidenschaft und Augenmaß : sozialwissenschaftliche Perspektiven auf Entwicklung, Verwaltung, Umwelt und Klima : Festschrift für Harald Fuhr Y1 - 2020 SN - 978-3-8487-5249-2 SN - 978-3-8452-9429-2 U6 - https://doi.org/10.5771/9783845294292-285 SP - 285 EP - 298 PB - Nomos CY - Baden-Baden ER - TY - CHAP A1 - Jann, Werner ED - Hickmann, Thomas ED - Lederer, Markus T1 - The modern state and administrative reform BT - the times they are a-changin’ T2 - Leidenschaft und Augenmaß : sozialwissenschaftliche Perspektiven auf Entwicklung, Verwaltung, Umwelt und Klima : Festschrift für Harald Fuhr Y1 - 2020 SN - 978-3-8487-5249-2 SN - 978-3-8452-9429-2 U6 - https://doi.org/10.5771/9783845294292-59 SP - 59 EP - 72 PB - Nomos CY - Baden-Baden ER - TY - CHAP A1 - Hustedt, Thurid A1 - Seyfried, Markus ED - Hickmann, Thomas ED - Lederer, Markus T1 - Challenges, triggers and initiators of climate policies and implications for policy formulation T2 - Leidenschaft und Augenmaß Y1 - 2020 SN - 978-3-8487-5249-2 SN - 978-3-8452-9429-2 U6 - https://doi.org/10.5771/9783845294292-169 SP - 169 EP - 180 PB - Nomos CY - Baden-Baden ER - TY - GEN A1 - Hermanussen, Michael A1 - Scheffler, Christiane A1 - Pulungan, Aman B. A1 - Batubara, Jose R. L. A1 - Julia, Madarina A1 - Bogin, Barry T1 - Response to the correspondence referring to our article "Stunting is not a synonym of malnutrition" (2018EJCN0997RR) by Conny Tanjung, Titis Prawitasari, Damayanti Rusli Sjarif T2 - European journal of clinical nutrition Y1 - 2020 U6 - https://doi.org/10.1038/s41430-020-0571-1 SN - 0954-3007 SN - 1476-5640 VL - 74 IS - 3 SP - 529 EP - 531 PB - Nature Publ. Group CY - New York, NY ER - TY - GEN A1 - Wang, Wei-shi A1 - Oswald, Sascha A1 - Gräff, Thomas A1 - Lensing, Hermann-Josef A1 - Liu, Tie A1 - Strasser, Daniel A1 - Munz, Matthias T1 - Correction: Impact of river reconstruction on groundwater flow during bank filtration assessed by transient three-dimensional modelling of flow and heat transport. - Hydrogeology Journal. - Berlin: Springer. - 28 (2020) , S. 723. - https://doi.org/10.1007/s10040-019-02063-3 T2 - Hydrogeology journal : official journal of the International Association of Hydrogeologists T2 - Erratum: Impact de la reconstruction d’une rivière sur l’écoulement des eaux souterraines via la filtration sur berge évalué par un modèle tridimensionnel en régime transitoire de l’écoulement et du transport de chaleur. - Berlin: Springer. - 28 (2020) , S. 723. - https://doi.org/10.1007/s10040-019-02063-3 T2 - Erratum: Impacto de la restauración de un río en el flujo de agua subterránea durante la filtración en las márgenes, evaluado mediante la modelización tridimensional transitoria del flujo y el transporte de calor. - Berlin: Springer. - 28 (2020) , S. 723. - https://doi.org/10.1007/s10040-019-02063-3 Y1 - 2020 U6 - https://doi.org/10.1007/s10040-020-02221-y SN - 1431-2174 SN - 1435-0157 VL - 28 IS - 7 SP - 2633 EP - 2634 PB - Springer CY - Berlin ; Heidelberg ; New York, NY ER - TY - JOUR A1 - Raoufi, Meysam A1 - Hörmann, Ulrich A1 - Ligorio, Giovanni A1 - Hildebrandt, Jana A1 - Pätzel, Michael A1 - Schultz, Thorsten A1 - Perdigon-Toro, Lorena A1 - Koch, Norbert A1 - List-Kratochvil, Emil A1 - Hecht, Stefan A1 - Neher, Dieter T1 - Simultaneous effect of ultraviolet radiation and surface modification on the work function and hole injection properties of ZnO thin films JF - Physica Status Solidi. A , Applications and materials science N2 - The combined effect of ultraviolet (UV) light soaking and self-assembled monolayer deposition on the work function (WF) of thin ZnO layers and on the efficiency of hole injection into the prototypical conjugated polymer poly(3-hexylthiophen-2,5-diyl) (P3HT) is systematically investigated. It is shown that the WF and injection efficiency depend strongly on the history of UV light exposure. Proper treatment of the ZnO layer enables ohmic hole injection into P3HT, demonstrating ZnO as a potential anode material for organic optoelectronic devices. The results also suggest that valid conclusions on the energy-level alignment at the ZnO/organic interfaces may only be drawn if the illumination history is precisely known and controlled. This is inherently problematic when comparing electronic data from ultraviolet photoelectron spectroscopy (UPS) measurements carried out under different or ill-defined illumination conditions. KW - charge injection across hybrid interfaces KW - energy-level alignments KW - hybrid metal oxides KW - organic interfaces Y1 - 2020 U6 - https://doi.org/10.1002/pssa.201900876 SN - 1862-6300 SN - 1862-6319 VL - 217 IS - 5 SP - 1 EP - 6 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Démaris, Alise A1 - Grišić, Ana-Marija A1 - Huisinga, Wilhelm A1 - Walter, Reinisch A1 - Kloft, Charlotte T1 - Evaluation of dosing strategies of anti-TNF alpha monoclonal antibodies using pharmacokinetic modelling and simulation T2 - Journal of Crohn's and Colitis N2 - Background: Anti-TNFα monoclonal antibodies (mAbs) are a well-established treatment for patients with Crohn’s disease (CD). However, subtherapeutic concentrations of mAbs have been related to a loss of response during the first year of therapy1. Therefore, an appropriate dosing strategy is crucial to prevent the underexposure of mAbs for those patients. The aim of our study was to assess the impact of different dosing strategies (fixed dose or body size descriptor adapted) on drug exposure and the target concentration attainment for two different anti-TNFα mAbs: infliximab (IFX, body weight (BW)-based dosing) and certolizumab pegol (CZP, fixed dosing). For this purpose, a comprehensive pharmacokinetic (PK) simulation study was performed. Methods: A virtual population of 1000 clinically representative CD patients was generated based on the distribution of CD patient characteristics from an in-house clinical database (n = 116). Seven dosing regimens were investigated: fixed dose and per BW, lean BW (LBW), body surface area, height, body mass index and fat-free mass. The individual body size-adjusted doses were calculated from patient generated body size descriptor values. Then, using published PK models for IFX and CZP in CD patients2,3, for each patient, 1000 concentration–time profiles were simulated to consider the typical profile of a specific patient as well as the range of possible individual profiles due to unexplained PK variability across patients. For each dosing strategy, the variability in maximum and minimum mAb concentrations (Cmax and Cmin, respectively), area under the concentration-time curve (AUC) and the per cent of patients reaching target concentration were assessed during maintenance therapy. Results: For IFX and CZP, Cmin showed the highest variability between patients (CV ≈110% and CV ≈80%, respectively) with a similar extent across all dosing strategies. For IFX, the per cent of patients reaching the target (Cmin = 5 µg/ml) was similar across all dosing strategies (~15%). For CZP, the per cent of patients reaching the target average concentration of 17 µg/ml ranged substantially (52–71%), being the highest for LBW-adjusted dosing. Conclusion: By using a PK simulation approach, different dosing regimen of IFX and CZP revealed the highest variability for Cmin, the most commonly used PK parameter guiding treatment decisions, independent upon dosing regimen. Our results demonstrate similar target attainment with fixed dosing of IFX compared with currently recommended BW-based dosing. For CZP, the current fixed dosing strategy leads to comparable percentage of patients reaching target as the best performing body size-adjusted dosing (66% vs. 71%, respectively). KW - linical databases KW - crohn's disease KW - regimen KW - monoclonal antibodies KW - body surface area KW - infliximab KW - fat-free mass KW - certolizumab pegol KW - body mass index procedure Y1 - 2020 U6 - https://doi.org/10.1093/ecco-jcc/jjz203.201 SN - 1873-9946 SN - 1876-4479 VL - 14 IS - Supp. 1 SP - S171 EP - S172 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Jarecki, Jana B. A1 - Tan, Jolene H. A1 - Jenny, Mirjam T1 - A framework for building cognitive process models JF - Psychonomic bulletin & review : a journal of the Psychonomic Society N2 - The termprocess modelis widely used, but rarely agreed upon. This paper proposes a framework for characterizing and building cognitive process models. Process models model not only inputs and outputs but also model the ongoing information transformations at a given level of abstraction. We argue that the following dimensions characterize process models: They have a scope that includes different levels of abstraction. They specify a hypothesized mental information transformation. They make predictions not only for the behavior of interest but also for processes. The models' predictions for the processes can be derived from the input, without reverse inference from the output data. Moreover, the presumed information transformation steps are not contradicting current knowledge of human cognitive capacities. Lastly, process models require a conceptual scope specifying levels of abstraction for the information entering the mind, the proposed mental events, and the behavior of interest. This framework can be used for refining models before testing them or after testing them empirically, and it does not rely on specific modeling paradigms. It can be a guideline for developing cognitive process models. Moreover, the framework can advance currently unresolved debates about which models belong to the category of process models. KW - cognitive process model KW - cognitive model KW - computational model KW - definitions KW - Marr's levels Y1 - 2020 U6 - https://doi.org/10.3758/s13423-020-01747-2 SN - 1069-9384 SN - 1531-5320 VL - 27 IS - 6 SP - 1218 EP - 1229 PB - Springer CY - New York, NY ER - TY - JOUR A1 - Ben Dor, Yoav A1 - Neugebauer, Ina A1 - Enzel, Yehouda A1 - Schwab, Markus J. A1 - Tjallingii, Rik A1 - Erel, Yigal A1 - Brauer, Achim T1 - Reply to comment on: Ben Dor, Yoav et al. : Varves of the Dead Sea sedimentary record. - In: Quaternary science reviews : the international multidisciplinary research and review journal. - 215 (2019), S. 173 - 184. - (ISSN: 0277-3791). - https://doi.org/10.1016/j.quascirev.2019.04.011 JF - Quaternary science reviews : the international multidisciplinary research and review journal N2 - In the comment on "Varves of the Dead Sea sedimentary record." Quaternary Science Reviews 215 (Ben Dor et al., 2019): 173-184. by R. Bookman, two recently published papers are suggested to prove that the interpretation of the laminated sedimentary sequence of the Dead Sea, deposited mostly during MIS2 and Holocene pluvials, as annual deposits (i.e., varves) is wrong. In the following response, we delineate several lines of evidence which coalesce to demonstrate that based on the vast majority of evidence, including some of the evidence provided in the comment itself, the interpretation of these sediments as varves is the more likely scientific conclusion. We further discuss the evidence brought up in the comment and its irrelevance and lack of robustness for addressing the question under discussion. Y1 - 2020 U6 - https://doi.org/10.1016/j.quascirev.2019.106063 SN - 0277-3791 VL - 231 PB - Elsevier CY - Amsterdam [u.a.] ER - TY - JOUR A1 - Terao, Mineko A1 - Garattini, Enrico A1 - Romão, Maria João A1 - Leimkühler, Silke T1 - Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes JF - The journal of biological chemistry N2 - Aldehyde oxidases (AOXs) are a small group of enzymes belonging to the larger family of molybdo-flavoenzymes, along with the well-characterized xanthine oxidoreductase. The two major types of reactions that are catalyzed by AOXs are the hydroxylation of heterocycles and the oxidation of aldehydes to their corresponding carboxylic acids. Different animal species have different complements of AOX genes. The two extremes are represented in humans and rodents; whereas the human genome contains a single active gene (AOX1), those of rodents, such as mice, are endowed with four genes (Aox1-4), clustering on the same chromosome, each encoding a functionally distinct AOX enzyme. It still remains enigmatic why some species have numerous AOX enzymes, whereas others harbor only one functional enzyme. At present, little is known about the physiological relevance of AOX enzymes in humans and their additional forms in other mammals. These enzymes are expressed in the liver and play an important role in the metabolisms of drugs and other xenobiotics. In this review, we discuss the expression, tissue-specific roles, and substrate specificities of the different mammalian AOX enzymes and highlight insights into their physiological roles. KW - metalloenzyme KW - molybdenum KW - mouse KW - drug metabolism KW - flavoprotein KW - xenobiotic KW - oxidase KW - oxygen radicals KW - iron-sulfur protein KW - aldehyde oxidase (AOX) KW - enzyme evolution KW - metal-containing enzyme KW - molybdenum cofactor (Moco) KW - molybdo-flavoenzyme KW - 2Fe-2S cluster KW - flavin adenine dinucleotide (FAD) Y1 - 2020 U6 - https://doi.org/10.1074/jbc.REV119.007741 SN - 0021-9258 SN - 1083-351X VL - 295 IS - 16 SP - 5377 EP - 5389 PB - American Society for Biochemistry and Molecular Biology CY - Rockville ER - TY - GEN A1 - Hölzle, Katharina A1 - Boer, Harry A1 - Björk, Jennie T1 - Crisis management through creativity and innovation BT - storytelling, moral organizational creativity, and open innovation as creative means to spark innovation T2 - Creativity and innovation management Y1 - 2020 U6 - https://doi.org/10.1111/caim.12385 SN - 0963-1690 SN - 1467-8691 VL - 29 IS - 2 SP - 195 EP - 197 PB - Wiley-Blackwell CY - Oxford [u.a.] ER - TY - JOUR A1 - Kunstmann, Ruth Sonja A1 - Engström, Olof A1 - Wehle, Marko A1 - Widmalm, Göran A1 - Santer, Mark A1 - Barbirz, Stefanie T1 - Increasing the affinity of an O-Antigen polysaccharide binding site in Shigella flexneri bacteriophage Sf6 tailspike protein JF - Chemistry – A European Journal N2 - Broad and unspecific use of antibiotics accelerates spread of resistances. Sensitive and robust pathogen detection is thus important for a more targeted application. Bacteriophages contain a large repertoire of pathogen-binding proteins. These tailspike proteins (TSP) often bind surface glycans and represent a promising design platform for specific pathogen sensors. We analysed bacteriophage Sf6 TSP that recognizes the O-polysaccharide of dysentery-causing Shigella flexneri to develop variants with increased sensitivity for sensor applications. Ligand polyrhamnose backbone conformations were obtained from 2D H-1,H-1-trNOESY NMR utilizing methine-methine and methine-methyl correlations. They agreed well with conformations obtained from molecular dynamics (MD), validating the method for further predictions. In a set of mutants, MD predicted ligand flexibilities that were in good correlation with binding strength as confirmed on immobilized S. flexneri O-polysaccharide (PS) with surface plasmon resonance. In silico approaches combined with rapid screening on PS surfaces hence provide valuable strategies for TSP-based pathogen sensor design. KW - carbohydrates KW - molecular dynamics simulations KW - NMR spectroscopy KW - protein-carbohydrate interactions KW - surface plasmon resonance Y1 - 2020 U6 - https://doi.org/10.1002/chem.202000495 SN - 0947-6539 SN - 1521-3765 VL - 26 IS - 32 SP - 7263 EP - 7273 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Köster, Antonia A1 - Matt, Christian A1 - Hess, Thomas T1 - Do all roads lead to Rome? BT - exploring the relationship between social referrals, referral propensity and stickiness to video-on-demand websites JF - Business and Information Systems Engineering N2 - Content website providers have two main goals: They seek to attract consumers and to keep them on their websites as long as possible. To reach potential consumers, they can utilize several online channels, such as paid search results or advertisements on social media, all of which usually require a substantial marketing budget. However, with rising user numbers of online communication tools, website providers increasingly integrate social sharing buttons on their websites to encourage existing consumers to facilitate referrals to their social networks. While little is known about this social form of guiding consumers to a content website, the study proposes that the way in which consumers reach a website is related to their stickiness to the website and their propensity to refer content to others. By using a unique clickstream data set of a video-on-demand website, the study compares consumers referred by their social network to those consumers arriving at the website via organic search or social media advertisements in terms of stickiness to the website (e.g., visit length, number of page views, video starts) and referral likelihood. The results show that consumers referred through social referrals spend more time on the website, view more pages, and start more videos than consumers who respond to social media advertisements, but less than those coming through organic search. Concerning referral propensity, the results indicate that consumers attracted to a website through social referrals are more likely to refer content to others than those who came through organic search or social media advertisements. The study offers direct insights to managers and recommends an increase in their efforts to promote social referrals on their websites. KW - social referrals KW - organic search KW - social media advertising KW - website stickiness KW - referral propensity Y1 - 2020 U6 - https://doi.org/10.1007/s12599-020-00660-1 SN - 1867-0202 VL - 63 SP - 349 EP - 366 PB - Springer CY - Wiesbaden ER - TY - CHAP A1 - Dieter, Heribert ED - Mirchandani, Maya ED - Suri, Shoba ED - Warjri, Laetitia T1 - Germany in the Covid-19-crisis BT - more robust than other European countries? T2 - The viral world N2 - The COVID-19 virus has hit Germany as unexpectedly as other European countries. For a few weeks, Germans thought that COVID-19 was an issue for Asian states and not for their country. Although Germany continues to be affected by the coronavirus, the situation is nowhere as dire as it was in Britain, Italy or Spain. The race to lift restrictions in Germany began in May, and by early June, the country may be back to normal. Germany, with its enormous financial resources and a well-equipped medical sector, appears to be better placed than other economies to weather the storm. Y1 - 2020 UR - https://www.orfonline.org/wp-content/uploads/2020/06/The-Viral-World.pdf SN - 978-93-90159-27-7 SP - 50 EP - 55 PB - Observer Research Foundation CY - New Delhi, India ER - TY - CHAP A1 - Dieter, Heribert ED - Hickmann, Thomas ED - Lederer, Markus T1 - Germany as a leading power BT - a pipe dream T2 - Leidenschaft und Augenmaß Y1 - 2020 SN - 978-3-8487-5249-2 SN - 978-3-8452-9429-2 U6 - https://doi.org/10.5771/9783845294292-73 SP - 73 EP - 84 PB - Nomos CY - Baden-Baden ET - 1. Auflage ER - TY - JOUR A1 - Griscom, Bronson W. A1 - Busch, Jonah A1 - Cook-Patton, Susan C. A1 - Ellis, Peter W. A1 - Funk, Jason A1 - Leavitt, Sara M. A1 - Lomax, Guy A1 - Turner, Will R. A1 - Chapman, Melissa A1 - Streck, Charlotte T1 - National mitigation potential from natural climate solutions in the tropics JF - Biological sciences N2 - Better land stewardship is needed to achieve the Paris Agreement's temperature goal, particularly in the tropics, where greenhouse gas emissions from the destruction of ecosystems are largest, and where the potential for additional land carbon storage is greatest. As countries enhance their nationally determined contributions (NDCs) to the Paris Agreement, confusion persists about the potential contribution of better land stewardship to meeting the Agreement's goal to hold global warming below 2 degrees C. We assess cost-effective tropical country-level potential of natural climate solutions (NCS)-protection, improved management and restoration of ecosystems-to deliver climate mitigation linked with sustainable development goals (SDGs). We identify groups of countries with distinctive NCS portfolios, and we explore factors (governance, financial capacity) influencing the feasibility of unlocking national NCS potential. Cost-effective tropical NCS offers globally significant climate mitigation in the coming decades (6.56 Pg CO(2)e yr(-1) at less than 100 US$ per Mg CO(2)e). In half of the tropical countries, cost-effective NCS could mitigate over half of national emissions. In more than a quarter of tropical countries, cost-effective NCS potential is greater than national emissions. We identify countries where, with international financing and political will, NCS can cost-effectively deliver the majority of enhanced NDCs while transforming national economies and contributing to SDGs. This article is part of the theme issue 'Climate change and ecosystems: threats, opportunities and solutions'. KW - natural climate solutions KW - climate mitigation KW - protection KW - land management KW - restoration KW - Paris Agreement Y1 - 2020 U6 - https://doi.org/10.1098/rstb.2019.0126 SN - 0080-4622 SN - 0962-8436 SN - 1471-2970 VL - 375 IS - 1794 SP - 1 EP - 11 PB - The Royal Society Publishing CY - London ER - TY - JOUR A1 - Thirumalaikumar, Venkatesh P. A1 - Gorka, Michal A1 - Schulz, Karina A1 - Masclaux-Daubresse, Celine A1 - Sampathkumar, Arun A1 - Skirycz, Aleksandra A1 - Vierstra, Richard D. A1 - Balazadeh, Salma T1 - Selective autophagy regulates heat stress memory in Arabidopsis by NBR1-mediated targeting of HSP90.1 and ROF1 JF - Autophagy N2 - In nature, plants are constantly exposed to many transient, but recurring, stresses. Thus, to complete their life cycles, plants require a dynamic balance between capacities to recover following cessation of stress and maintenance of stress memory. Recently, we uncovered a new functional role for macroautophagy/autophagy in regulating recovery from heat stress (HS) and resetting cellular memory of HS inArabidopsis thaliana. Here, we demonstrated that NBR1 (next to BRCA1 gene 1) plays a crucial role as a receptor for selective autophagy during recovery from HS. Immunoblot analysis and confocal microscopy revealed that levels of the NBR1 protein, NBR1-labeled puncta, and NBR1 activity are all higher during the HS recovery phase than before. Co-immunoprecipitation analysis of proteins interacting with NBR1 and comparative proteomic analysis of annbr1-null mutant and wild-type plants identified 58 proteins as potential novel targets of NBR1. Cellular, biochemical and functional genetic studies confirmed that NBR1 interacts with HSP90.1 (heat shock protein 90.1) and ROF1 (rotamase FKBP 1), a member of the FKBP family, and mediates their degradation by autophagy, which represses the response to HS by attenuating the expression ofHSPgenes regulated by the HSFA2 transcription factor. Accordingly, loss-of-function mutation ofNBR1resulted in a stronger HS memory phenotype. Together, our results provide new insights into the mechanistic principles by which autophagy regulates plant response to recurrent HS. KW - Arabidopsis thaliana KW - heat stress KW - HSFA2 KW - HSP90.1 KW - NBR1 KW - ROF1 KW - selective autophagy KW - stress memory KW - stress recovery Y1 - 2020 U6 - https://doi.org/10.1080/15548627.2020.1820778 SN - 1554-8635 VL - 17 IS - 9 SP - 2184 EP - 2199 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Gleich, Tobias A1 - Spitta, Gianna A1 - Butler, Oisin A1 - Zacharias, Kristin A1 - Aydin, Semiha A1 - Sebold, Miriam Hannah A1 - Garbusow, Maria A1 - Rapp, Michael A. A1 - Schubert, Florian A1 - Buchert, Ralph A1 - Heinz, Andreas A1 - Gallinat, Jürgen T1 - Dopamine D2/3 receptor availability in alcohol use disorder and individuals at high risk BT - towards a dimensional approach JF - Addiction Biology N2 - Alcohol use disorder (AUD) is the most common substance use disorder worldwide. Although dopamine-related findings were often observed in AUD, associated neurobiological mechanisms are still poorly understood. Therefore, in the present study, we investigate D2/3 receptor availability in healthy participants, participants at high risk (HR) to develop addiction (not diagnosed with AUD), and AUD patients in a detoxified stage, applying F-18-fallypride positron emission tomography (F-18-PET). Specifically, D2/3 receptor availability was investigated in (1) 19 low-risk (LR) controls, (2) 19 HR participants, and (3) 20 AUD patients after alcohol detoxification. Quality and severity of addiction were assessed with clinical questionnaires and (neuro)psychological tests. PET data were corrected for age of participants and smoking status. In the dorsal striatum, we observed significant reductions of D2/3 receptor availability in AUD patients compared with LR participants. Further, receptor availability in HR participants was observed to be intermediate between LR and AUD groups (linearly decreasing). Still, in direct comparison, no group difference was observed between LR and HR groups or between HR and AUD groups. Further, the score of the Alcohol Dependence Scale (ADS) was inversely correlated with D2/3 receptor availability in the combined sample. Thus, in line with a dimensional approach, striatal D2/3 receptor availability showed a linear decrease from LR participants to HR participants to AUD patients, which was paralleled by clinical measures. Our study shows that a core neurobiological feature in AUD seems to be detectable in an early, subclinical state, allowing more individualized alcohol prevention programs in the future. KW - alcohol KW - D2/3 receptors KW - dependence KW - dopamine KW - high risk KW - PET Y1 - 2020 U6 - https://doi.org/10.1111/adb.12915 SN - 1369-1600 VL - 26 IS - 2 SP - 1 EP - 10 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Leins, Johannes A. A1 - Banitz, Thomas A1 - Grimm, Volker A1 - Drechsler, Martin T1 - High-resolution PVA along large environmental gradients to model the combined effects of climate change and land use timing BT - lessons from the large marsh grasshopper JF - Ecological modelling : international journal on ecological modelling and systems ecology N2 - Both climate change and land use regimes affect the viability of populations, but they are often studied separately. Moreover, population viability analyses (PVAs) often ignore the effects of large environmental gradients and use temporal resolutions that are too coarse to take into account that different stages of a population's life cycle may be affected differently by climate change. Here, we present the High-resolution Large Environmental Gradient (HiLEG) model and apply it in a PVA with daily resolution based on daily climate projections for Northwest Germany. We used the large marsh grasshopper (LMG) as the target species and investigated (1) the effects of climate change on the viability and spatial distribution of the species, (2) the influence of the timing of grassland mowing on the species and (3) the interaction between the effects of climate change and grassland mowing. The stageand cohort-based model was run for the spatially differentiated environmental conditions temperature and soil moisture across the whole study region. We implemented three climate change scenarios and analyzed the population dynamics for four consecutive 20-year periods. Climate change alone would lead to an expansion of the regions suitable for the LMG, as warming accelerates development and due to reduced drought stress. However, in combination with land use, the timing of mowing was crucial, as this disturbance causes a high mortality rate in the aboveground life stages. Assuming the same date of mowing throughout the region, the impact on viability varied greatly between regions due to the different climate conditions. The regional negative effects of the mowing date can be divided into five phases: (1) In early spring, the populations were largely unaffected in all the regions; (2) between late spring and early summer, they were severely affected only in warm regions; (3) in summer, all the populations were severely affected so that they could hardly survive; (4) between late summer and early autumn, they were severely affected in cold regions; and (5) in autumn, the populations were equally affected across all regions. The duration and start of each phase differed slightly depending on the climate change scenario and simulation period, but overall, they showed the same pattern. Our model can be used to identify regions of concern and devise management recommendations. The model can be adapted to the life cycle of different target species, climate projections and disturbance regimes. We show with our adaption of the HiLEG model that high-resolution PVAs and applications on large environmental gradients can be reconciled to develop conservation strategies capable of dealing with multiple stressors. KW - Climate change KW - Land use KW - Population viability analysis KW - Stage-based model KW - High resolution KW - Environmental gradients Y1 - 2020 U6 - https://doi.org/10.1016/j.ecolmodel.2020.109355 SN - 0304-3800 SN - 1872-7026 VL - 440 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Offrede, Tom F. A1 - Jacobi, Jidde A1 - Rebernik, Teja A1 - de Jong, Lisanne A1 - Keulen, Stefanie A1 - Veenstra, Pauline A1 - Noiray, Aude A1 - Wieling, Martijn T1 - The impact of alcohol on L1 versus L2 JF - Language and Speech N2 - Alcohol intoxication is known to affect many aspects of human behavior and cognition; one of such affected systems is articulation during speech production. Although much research has revealed that alcohol negatively impacts pronunciation in a first language (L1), there is only initial evidence suggesting a potential beneficial effect of inebriation on articulation in a non-native language (L2). The aim of this study was thus to compare the effect of alcohol consumption on pronunciation in an L1 and an L2. Participants who had ingested different amounts of alcohol provided speech samples in their L1 (Dutch) and L2 (English), and native speakers of each language subsequently rated the pronunciation of these samples on their intelligibility (for the L1) and accent nativelikeness (for the L2). These data were analyzed with generalized additive mixed modeling. Participants' blood alcohol concentration indeed negatively affected pronunciation in L1, but it produced no significant effect on the L2 accent ratings. The expected negative impact of alcohol on L1 articulation can be explained by reduction in fine motor control. We present two hypotheses to account for the absence of any effects of intoxication on L2 pronunciation: (1) there may be a reduction in L1 interference on L2 speech due to decreased motor control or (2) alcohol may produce a differential effect on each of the two linguistic subsystems. KW - acute alcohol consumption KW - articulation KW - speech KW - bilingualism Y1 - 2020 U6 - https://doi.org/10.1177/0023830920953169 SN - 1756-6053 SN - 0023-8309 VL - 64 IS - 3 SP - 681 EP - 692 PB - SAGE Publications CY - Thousand Oaks ER - TY - JOUR A1 - Tschorn, Mira A1 - Kuhlmann, Stella Linnea A1 - Rieckmann, Nina A1 - Beer, Katja A1 - Grosse, Laura A1 - Arolt, Volker A1 - Waltenberger, Johannes A1 - Haverkamp, Wilhelm A1 - Müller-Nordhorn, Jacqueline A1 - Hellweg, Rainer A1 - Ströhle, Andreas T1 - Brain-derived neurotrophic factor, depressive symptoms and somatic comorbidity in patients with coronary heart disease JF - Acta Neuropsychiatrica N2 - Objective: Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analysed the relationship between BDNF and depression in a sample of patients with CHD and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS) or congestive heart failure (CHF). Methods: The following variables were assessed for 225 hospitalised patients with CHD: BDNF concentrations, depression [Patient Health Questionnaire-9 (PHQ-9)], somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status and antidepressant treatment. Results: Regression models revealed that BDNF was not associated with severity of depression. Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p = 0.04), this was not statistically significant after controlling for confounders (p = 0.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p = 0.08, p = 0.06, respectively). BDNF was reduced in patients with CHF (p = 0.02). There was no covariate-adjusted, significant association between BDNF and ACS. Conclusion: Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF. KW - depression KW - BDNF KW - coronary heart disease KW - heart failure KW - somatic comorbidity KW - acute coronary syndrome Y1 - 2020 U6 - https://doi.org/10.1017/neu.2020.31 SN - 1601-5215 SN - 0924-2708 VL - 33 IS - 1 SP - 22 EP - 30 PB - Cambridge Univ. Press CY - Cambridge ER - TY - JOUR A1 - von der Malsburg, Titus Raban A1 - Poppels, Till A1 - Levy, Roger P. T1 - Implicit gender bias in linguistic descriptions for expected events BT - the cases of the 2016 United States and 2017 United Kingdom elections JF - Psychological Science N2 - Gender stereotypes influence subjective beliefs about the world, and this is reflected in our use of language. But do gender biases in language transparently reflect subjective beliefs? Or is the process of translating thought to language itself biased? During the 2016 United States (N = 24,863) and 2017 United Kingdom (N = 2,609) electoral campaigns, we compared participants' beliefs about the gender of the next head of government with their use and interpretation of pronouns referring to the next head of government. In the United States, even when the female candidate was expected to win, she pronouns were rarely produced and induced substantial comprehension disruption. In the United Kingdom, where the incumbent female candidate was heavily favored, she pronouns were preferred in production but yielded no comprehension advantage. These and other findings suggest that the language system itself is a source of implicit biases above and beyond previously known biases, such as those measured by the Implicit Association Test. KW - language KW - psycholinguistics KW - event expectations KW - reference KW - implicit bias KW - open data KW - open materials Y1 - 2020 U6 - https://doi.org/10.1177/0956797619890619 SN - 0956-7976 SN - 1467-9280 VL - 31 IS - 2 SP - 115 EP - 128 PB - Sage CY - London ER - TY - JOUR A1 - Köster, Moritz A1 - Kayhan, Ezgi A1 - Langeloh, Miriam A1 - Hoehl, Stefanie T1 - Making sense of the world BT - Infant learning from a predictive processing perspective JF - Perspectives on Psychological Science N2 - For human infants, the first years after birth are a period of intense exploration-getting to understand their own competencies in interaction with a complex physical and social environment. In contemporary neuroscience, the predictive-processing framework has been proposed as a general working principle of the human brain, the optimization of predictions about the consequences of one's own actions, and sensory inputs from the environment. However, the predictive-processing framework has rarely been applied to infancy research. We argue that a predictive-processing framework may provide a unifying perspective on several phenomena of infant development and learning that may seem unrelated at first sight. These phenomena include statistical learning principles, infants' motor and proprioceptive learning, and infants' basic understanding of their physical and social environment. We discuss how a predictive-processing perspective can advance the understanding of infants' early learning processes in theory, research, and application. KW - cognition KW - infant development KW - neuroscience KW - perception KW - social cognition Y1 - 2020 U6 - https://doi.org/10.1177/1745691619895071 SN - 1745-6916 SN - 1745-6924 VL - 15 IS - 3 SP - 562 EP - 571 PB - Sage CY - London ER - TY - JOUR A1 - Paoli, Antonio A1 - Moro, Tatiana A1 - Lorenzetti, Silvio A1 - Seiler, Jan A1 - Lüthy, Fabian A1 - Gross, Micah A1 - Roggio, Federico A1 - Chaabene, Helmi A1 - Musumeci, Giuseppe T1 - The “Journal of Functional Morphology and Kinesiology” Journal Club Series BT - Resistance Training JF - Journal of Functional Morphology and Kinesiology N2 - We are glad to introduce the Second Journal Club of Volume Five, Second Issue. This edition is focused on relevant studies published in the last few years in the field of resistance training, chosen by our Editorial Board members and their colleagues. We hope to stimulate your curiosity in this field and to share with you the passion for the sport, seen also from the scientific point of view. The Editorial Board members wish you an inspiring lecture. Y1 - 2020 U6 - https://doi.org/10.3390/jfmk5020025 SN - 2411-5142 VL - 5 IS - 2 SP - 1 EP - 9 PB - MDPI CY - Basel ER - TY - JOUR A1 - Höhle, Barbara A1 - Fritzsche, Tom A1 - Meß, Katharina A1 - Philipp, Mareike A1 - Gafos, Adamantios I. T1 - Only the right noise? BT - Effects of phonetic and visual input variability on 14-month-olds' minimal pair word learning JF - Developmental Science N2 - Seminal work by Werker and colleagues (Stager & Werker [1997]Nature, 388, 381-382) has found that 14-month-old infants do not show evidence for learning minimal pairs in the habituation-switch paradigm. However, when multiple speakers produce the minimal pair in acoustically variable ways, infants' performance improves in comparison to a single speaker condition (Rost & McMurray [2009]Developmental Science, 12, 339-349). The current study further extends these results and assesses how different kinds of input variability affect 14-month-olds' minimal pair learning in the habituation-switch paradigm testing German learning infants. The first two experiments investigated word learning when the labels were spoken by a single speaker versus when the labels were spoken by multiple speakers. In the third experiment we studied whether non-acoustic variability, implemented by visual variability of the objects presented together with the labels, would also affect minimal pair learning. We found enhanced learning in the multiple speakers compared to the single speaker condition, confirming previous findings with English-learning infants. In contrast, visual variability of the presented objects did not support learning. These findings both confirm and better delimit the beneficial role of speech-specific variability in minimal pair learning. Finally, we review different proposals on the mechanisms via which variability confers benefits to learning and outline what may be likely principles that underlie this benefit. We highlight among these the multiplicity of acoustic cues signalling phonemic contrasts and the presence of relations among these cues. It is in these relations where we trace part of the source for the apparent paradoxical benefit of variability in learning. KW - acoustic variability KW - habituation-switch paradigm KW - infant word learning KW - minimal pairs KW - phonological development KW - visual variability Y1 - 2020 U6 - https://doi.org/10.1111/desc.12950 SN - 1363-755X SN - 1467-7687 VL - 23 IS - 5 SP - 1 EP - 16 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Kosta, Peter T1 - On extraction and clitic climbing out of subject-/object-control clauses and causative clauses in romance and czech JF - Current developments in Slavic linguistics - twenty years after Y1 - 2020 SN - 978-3-631-67673-8 SN - 978-3-631-70974-0 SN - 978-3-631-70975-7 SN - 978-3-6530-7147-4 SP - 185 EP - 202 PB - Peter Lang CY - Berlin ER - TY - CHAP ED - Radeva-Bork, Teodora ED - Kosta, Peter T1 - Current developments in Slavic linguistics - twenty years after BT - based on selected papers from FDSL 11 T2 - Potsdam linguistic investigations N2 - The book offers a comprehensive overview of current research in Slavic linguistics from a theoretical and experimental perspective and from a variety of languages. The selected papers from the 11th European Conference on Formal Description of Slavic Languages (FDSL 11) that took place at the University of Potsdam in 2015, illustrate the advancement of Slavic linguistic studies and their outreach for the development of general linguistics. The guest paper by Noam Chomsky at the beginning of the book sets a clear sign in this direction and may be taken as an acknowledgement of the field. Y1 - 2020 SN - 978-3-631-67673-8 SN - 978-3-631-70974-0 SN - 978-3-631-70975-7 SN - 978-3-6530-7147-4 U6 - https://doi.org/10.3726/978-3-653-07147-4 SN - 1862-524X VL - 29 PB - Peter Lang CY - Berlin ER - TY - JOUR A1 - Knigge, Michel T1 - Use of evidence to promote inclusive education development commentary on Mel Ainscow. Promoting inclusion and equity in education BT - Lessons from international experiences JF - Nordic Journal of Studies in Educational Policy N2 - In his essay, Mel Ainscow looks at inclusion and equity from an international perspective and makes suggestions on how to develop inclusive education in a ‘whole-system approach’. After discussing different conceptions of inclusion and equity, he describes international policies which address them. From this international macro-level, Ainscow zooms in to the meso-level of the school and its immediate environment, defining dimensions to be considered for an inclusive school development. One of these dimensions is the ‘use of evidence’. In my comment, I want to focus on this dimension and discuss its scope and the potential to apply it in inclusive education development. As a first and important precondition, Ainscow explains that different circumstances lead to different linguistic uses of the term ‘inclusive education’. Thus, the term ‘inclusive education’ does not refer to an identical set of objectives across countries, and neither does the term ‘equity’. KW - evidence KW - inclusion KW - education KW - evaluation KW - practice Y1 - 2020 U6 - https://doi.org/10.1080/20020317.2020.1730093 SN - 2002-0317 VL - 6 IS - 1 SP - 21 EP - 24 PB - Taylor & Francis Group CY - London ER - TY - JOUR A1 - Raafat, Dina A1 - Mrochen, Daniel M. A1 - Al’Sholui, Fawaz A1 - Heuser, Elisa A1 - Ryll, René A1 - Pritchett-Corning, Kathleen R. A1 - Jacob, Jens A1 - Walther, Bernd A1 - Matuschka, Franz-Rainer A1 - Richter, Dania T1 - Molecular epidemiology of methicillin-susceptible and methicillin-resistant Staphylococcus aureus in wild, captive and laboratory rats BT - Effect of habitat on the nasal S. aureus population JF - Toxins N2 - Rats are a reservoir of human- and livestock-associated methicillin-resistant Staphylococcus aureus (MRSA). However, the composition of the natural S. aureus population in wild and laboratory rats is largely unknown. Here, 144 nasal S. aureus isolates from free-living wild rats, captive wild rats and laboratory rats were genotyped and profiled for antibiotic resistances and human-specific virulence genes. The nasal S. aureus carriage rate was higher among wild rats (23.4%) than laboratory rats (12.3%). Free-living wild rats were primarily colonized with isolates of clonal complex (CC) 49 and CC130 and maintained these strains even in husbandry. Moreover, upon livestock contact, CC398 isolates were acquired. In contrast, laboratory rats were colonized with many different S. aureus lineages—many of which are commonly found in humans. Five captive wild rats were colonized with CC398-MRSA. Moreover, a single CC30-MRSA and two CC130-MRSA were detected in free-living or captive wild rats. Rat-derived S. aureus isolates rarely harbored the phage-carried immune evasion gene cluster or superantigen genes, suggesting long-term adaptation to their host. Taken together, our study revealed a natural S. aureus population in wild rats, as well as a colonization pressure on wild and laboratory rats by exposure to livestock- and human-associated S. aureus, respectively. KW - Staphylococcus aureus KW - rat KW - clonal complex KW - host adaptation KW - livestock KW - laboratory KW - coagulation KW - immune evasion cluster KW - habitat KW - epidemiology Y1 - 2020 U6 - https://doi.org/10.3390/toxins12020080 SN - 2072-6651 VL - 12 IS - 2 SP - 1 EP - 22 PB - MDPI CY - Basel ER - TY - JOUR A1 - Kumar, Rohini A1 - Hesse, Fabienne A1 - Rao, P. Srinivasa A1 - Musolff, Andreas A1 - Jawitz, James A1 - Sarrazin, Francois A1 - Samaniego, Luis A1 - Fleckenstein, Jan H. A1 - Rakovec, Oldrich A1 - Thober, S. A1 - Attinger, Sabine T1 - Strong hydroclimatic controls on vulnerability to subsurface nitrate contamination across Europe JF - Nature Communications N2 - Subsurface contamination due to excessive nutrient surpluses is a persistent and widespread problem in agricultural areas across Europe. The vulnerability of a particular location to pollution from reactive solutes, such as nitrate, is determined by the interplay between hydrologic transport and biogeochemical transformations. Current studies on the controls of subsurface vulnerability do not consider the transient behaviour of transport dynamics in the root zone. Here, using state-of-the-art hydrologic simulations driven by observed hydroclimatic forcing, we demonstrate the strong spatiotemporal heterogeneity of hydrologic transport dynamics and reveal that these dynamics are primarily controlled by the hydroclimatic gradient of the aridity index across Europe. Contrasting the space-time dynamics of transport times with reactive timescales of denitrification in soil indicate that similar to 75% of the cultivated areas across Europe are potentially vulnerable to nitrate leaching for at least onethird of the year. We find that neglecting the transient nature of transport and reaction timescale results in a great underestimation of the extent of vulnerable regions by almost 50%. Therefore, future vulnerability and risk assessment studies must account for the transient behaviour of transport and biogeochemical transformation processes. KW - travel time distributions KW - groundwater vulnerability KW - flux tracking KW - transit-time KW - water age KW - nitrogen KW - model KW - dynamics KW - pollution KW - patterns Y1 - 2020 U6 - https://doi.org/10.1038/s41467-020-19955-8 SN - 2041-1723 VL - 11 IS - 1 SP - 1 EP - 10 PB - Nature Publishing Group UK CY - London ER - TY - JOUR A1 - Horn, Juliane A1 - Becher, Matthias A. A1 - Johst, Karin A1 - Kennedy, Peter J. A1 - Osborne, Juliet L. A1 - Radchuk, Viktoriia A1 - Grimm, Volker T1 - Honey bee colony performance affected by crop diversity and farmland structure BT - a modeling framework JF - Ecological applications N2 - Forage availability has been suggested as one driver of the observed decline in honey bees. However, little is known about the effects of its spatiotemporal variation on colony success. We present a modeling framework for assessing honey bee colony viability in cropping systems. Based on two real farmland structures, we developed a landscape generator to design cropping systems varying in crop species identity, diversity, and relative abundance. The landscape scenarios generated were evaluated using the existing honey bee colony model BEEHAVE, which links foraging to in-hive dynamics. We thereby explored how different cropping systems determine spatiotemporal forage availability and, in turn, honey bee colony viability (e.g., time to extinction, TTE) and resilience (indicated by, e.g., brood mortality). To assess overall colony viability, we developed metrics,P(H)andP(P,)which quantified how much nectar and pollen provided by a cropping system per year was converted into a colony's adult worker population. Both crop species identity and diversity determined the temporal continuity in nectar and pollen supply and thus colony viability. Overall farmland structure and relative crop abundance were less important, but details mattered. For monocultures and for four-crop species systems composed of cereals, oilseed rape, maize, and sunflower,P(H)andP(P)were below the viability threshold. Such cropping systems showed frequent, badly timed, and prolonged forage gaps leading to detrimental cascading effects on life stages and in-hive work force, which critically reduced colony resilience. Four-crop systems composed of rye-grass-dandelion pasture, trefoil-grass pasture, sunflower, and phacelia ensured continuous nectar and pollen supply resulting in TTE > 5 yr, andP(H)(269.5 kg) andP(P)(108 kg) being above viability thresholds for 5 yr. Overall, trefoil-grass pasture, oilseed rape, buckwheat, and phacelia improved the temporal continuity in forage supply and colony's viability. Our results are hypothetical as they are obtained from simplified landscape settings, but they nevertheless match empirical observations, in particular the viability threshold. Our framework can be used to assess the effects of cropping systems on honey bee viability and to develop land-use strategies that help maintain pollination services by avoiding prolonged and badly timed forage gaps. KW - apis mellifera KW - BEEHAVE KW - colony viability KW - crop diversity KW - cropping system KW - decline KW - forage availability KW - forage gaps KW - honey bees KW - landscape generator KW - modeling Y1 - 2020 U6 - https://doi.org/10.1002/eap.2216 SN - 1939-5582 SN - 1051-0761 VL - 31 IS - 1 SP - 1 EP - 22 PB - Wiley Periodicals LLC CY - Washington DC ER - TY - CHAP A1 - Krause, Hannes-Vincent A1 - Große Deters, Fenne A1 - Baumann, Annika T1 - The envy spiral BT - unraveling the black box of social media positivityorganizations T2 - Proceedings of the 28th European Conference on Information Systems (ECIS) : ECIS 2020 Research-in-Progress Papers N2 - On Social Networking Sites (SNS) users disclose mostly positive and often self-enhancing information. Scholars refer to this phenomenon as the positivity bias in SNS communication (PBSC). However, while theoretical explanations for this phenomenon have been proposed, an empirical proof of these theorized mechanisms is still missing. The project presented in this Research-in-Progress paper aims at explaining the PBSC with the mechanism specified in the self-enhancement envy spiral. Specifically, we hypothesize that feelings of envy drive people to post positive and self-enhancing content on SNS. To test this hypothesis, we developed an experimental design allowing to examine the causal effect of envy on the positivity of users’ subsequently posted content. In a preliminary study, we tested our manipulation of envy and could show its effectiveness in inducing different levels of envy between our groups. Our project will help to broaden the understanding of the complex dynamics of SNS and the potentially adverse driving forces underlying them. Y1 - 2020 UR - https://aisel.aisnet.org/ecis2020_rip/68 SN - 978-1-7336325-1-5 PB - AIS Electronic Library (AISeL) CY - [Erscheinungsort nicht ermittelbar] ER - TY - CHAP A1 - Vladova, Gergana A1 - Rüdian, Sylvio Leo T1 - From learners to educators BT - development of online courses by students for students T2 - The future of education N2 - The rapid growth of technology and its evolving potential to support the transformation of teaching and learning in post-secondary institutions is a major challenge to the basic understanding of both the university and the communities it serves. In higher education, the standard forms of learning and teaching are increasingly being challenged and a more comprehensive process of differentiation is taking place. Student-centered teaching methods are becoming increasingly important in course design and the role of the lecturer is changing from the knowledge mediator to moderator and learning companion. However, this is accelerating the need for strategically planned faculty support and a reassessment of the role of teaching and learning. Even though the benefits of experience-based learning approaches for the development of life skills are well known, most knowledge transfer is still realized through lectures in higher education. Teachers have the goal to design the curriculum, new assignments, and share insights into evolving pedagogy. Student engagement could be the most important factor in the learning success of university students, regardless of the university program or teaching format. Against this background, this article presents the development, application, and initial findings of an innovative learning concept. In this concept, students are allowed to deal with a scientific topic, but instead of a presentation and a written elaboration, their examination consists of developing an online course in terms of content, didactics, and concept to implement it in a learning environment, which is state of the art. The online courses include both self-created teaching material and interactive tasks. The courses are created to be available to other students as learning material after a review process and are thus incorporated into the curriculum. KW - future curriculum KW - digitalization KW - online courses KW - COVID-19 Y1 - 2020 UR - https://conference.pixel-online.net/files/foe/ed0010/FP/6824-CUD4792-FP-FOE10.pdf SN - 978-88-85813-87-8 U6 - https://doi.org/10.26352/E618_2384-9509 SN - 2420-9732 VL - 10 PB - Pixel CY - Florenz ER - TY - JOUR A1 - Witzel, Katja A1 - Abu Risha, Marua A1 - Albers, Philip A1 - Börnke, Frederik A1 - Hanschen, Franziska S. T1 - Corrigendum : Identification and characterization of three epithiospecifier protein isoforms in Brassica oleracea / Witzel, Katja; Abu Risha, Marua; Albers, Philip; Börnke, Frederike; Hanschen, Franziska S. - Lausanne: Frontiers Media, 2019. - Frontiers in plant science : FPLS. - 10 (2019) art. 1552. - doi: 10.3389/fpls.2019.01552 JF - Frontiers in plant science : FPLS KW - epithionitrile KW - expression profile KW - functional complementation KW - glucosinolate hydrolysis KW - nitrile KW - specifier proteins KW - tissue KW - specificity Y1 - 2020 U6 - https://doi.org/10.3389/fpls.2020.00523 SN - 1664-462X VL - 11 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Scholz-Ahrens, Katharina Elisabeth A1 - Ahrens, Frank A1 - Barth, Christian A. T1 - Nutritional and health attributes of milk and milk imitations JF - European journal of nutrition N2 - Purpose: Modern food technology allows designing products aiming to simulate and replace traditional food. In affluent societies there is a rising tendency to consume foods derived from plants including milk imitations or plant drinks based on cereals, nuts, legumes, oil seeds or other plant families. Herein we review production and composition of such drinks, summarize consumers' motivations to change from milk to plant drinks and highlight nutritional and health implications of consuming plant drinks instead of milk, in particular if non-fortified and if consumed by infants, children, adolescents and the elderly. Results: Whereas the macronutrient concentrations of some plant drinks (soy) may approach in some cases (protein) that of cow's milk, the nutritional quality of most plant drinks, e.g., the biological value of protein and the presence and amount of vitamins and essential minerals with high bioavailability does not. If cow's milk is exchanged for non-fortified and non-supplemented plant drinks consumers may risk deficiencies of calcium, zinc, iodine, vitamins B2, B12, D, A, and indispensable amino acids, particularly in infants and toddlers who traditionally consume significant portions of milk. The vegetable nature, appearance and taste of such plant drinks may be appealing to adult consumers and be chosen for adding variety to the menu. However, in young children fed exclusively such plant drinks severe metabolic disturbances may occur. Conclusion: Parents, dietitians, physicians and consumers should be aware of such potential risks, if non-fortified plant drinks are consumed instead of milk. KW - cow's milk KW - plant drinks KW - nutrient bioavailability KW - human nutrition KW - health risks Y1 - 2020 U6 - https://doi.org/10.1007/s00394-019-01936-3 SN - 1436-6207 SN - 1436-6215 VL - 59 IS - 1 SP - 19 EP - 34 PB - Springer CY - Heidelberg ER - TY - CHAP A1 - Brandenburger, Bonny A1 - Vladova, Gergana ED - Müller Werder, Claude ED - Erlemann, Jennifer T1 - Technology-enhanced learning in higher education BT - insights from a qualitative study on university-integrated makerspaces in six European countries T2 - Seamless Learning - lebenslanges, durchgängiges Lernen ermöglichen N2 - New technological applications such as Augmented Reality or Massive Open Online Courses (MOOCs) lead to alternative ways of learning. In order to be able to use this to its potential, the promotion of digital competencies “Digital Competence is the set of knowledge, skills, attitudes, abilities, strategies, and awareness that are required when using ICT and digital media to perform tasks; solve problems; communicate; manage information; collaborate; create and share content; and build knowledge effectively, efficiently, appropriately, critically, creatively, autonomously, flexibly, ethically, reflectively for work, le sure, participation, learning, and socialising.” (Ferrari, 2012). and a corresponding amount of practical "learning-by-doing" effects is required (cf. Ecker/Campbell 2019, p. 154). For this purpose, spaces and framework conditions must be created for application-based learning, which is also increasingly required by the employment market. In this context, we take a closer look at a new emerging subculture in university infrastructure called Maker Movement (MM). Our research work aims at investigating the pedagogical potential of particularly university-integrated makerspaces (MS) to enhance experiential learning with digital tools. To decode the innovative potential, we collected qualitative data from nine in-depth, semi-structured interviews with lab managers and researchers at European MS in six different countries. Y1 - 2020 SN - 978-3-8309-4244-3 SN - 978-3-8309-9244-8 U6 - https://doi.org/10.31244/9783830992448 SN - 1434-3436 SP - 27 EP - 37 PB - Waxmann CY - Münster ER - TY - JOUR A1 - Palmer, Matthew D. A1 - Gregory, Jonathan A1 - Bagge, Meike A1 - Calvert, Daley A1 - Hagedoorn, Jan Marius A1 - Howard, Tom A1 - Klemann, Volker A1 - Lowe, Jason A. A1 - Roberts, Chris A1 - Slangen, Aimee B. A. A1 - Spada, Giorgio T1 - Exploring the drivers of global and local sea‐level change over the 21st century and beyond JF - Earth's future N2 - We present a new set of global and local sea‐level projections at example tide gauge locations under the RCP2.6, RCP4.5, and RCP8.5 emissions scenarios. Compared to the CMIP5‐based sea‐level projections presented in IPCC AR5, we introduce a number of methodological innovations, including (i) more comprehensive treatment of uncertainties, (ii) direct traceability between global and local projections, and (iii) exploratory extended projections to 2300 based on emulation of individual CMIP5 models. Combining the projections with observed tide gauge records, we explore the contribution to total variance that arises from sea‐level variability, different emissions scenarios, and model uncertainty. For the period out to 2300 we further breakdown the model uncertainty by sea‐level component and consider the dependence on geographic location, time horizon, and emissions scenario. Our analysis highlights the importance of local variability for sea‐level change in the coming decades and the potential value of annual‐to‐decadal predictions of local sea‐level change. Projections to 2300 show a substantial degree of committed sea‐level rise under all emissions scenarios considered and highlight the reduced future risk associated with RCP2.6 and RCP4.5 compared to RCP8.5. Tide gauge locations can show large ( > 50%) departures from the global average, in some cases even reversing the sign of the change. While uncertainty in projections of the future Antarctic ice dynamic response tends to dominate post‐2100, we see substantial differences in the breakdown of model variance as a function of location, time scale, and emissions scenario. KW - climate change KW - CMIP5 models KW - RCP scenarios KW - sea-level projections KW - tide gauge observations Y1 - 2020 U6 - https://doi.org/10.1029/2019EF001413 SN - 2328-4277 VL - 8 IS - 9 SP - 1 EP - 25 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Varykhalov, Andrei A1 - Freyse, Friedrich A1 - Aguilera, Irene A1 - Battiato, Marco A1 - Krivenkov, Maxim A1 - Marchenko, Dmitry A1 - Bihlmayer, Gustav A1 - Blugel, Stefan A1 - Rader, Oliver A1 - Sanchez-Barriga, Jaime T1 - Effective mass enhancement and ultrafast electron dynamics of Au(111) surface state coupled to a quantum well JF - Physical Review Research N2 - We show that, although the equilibrium band dispersion of the Shockley-type surface state of two-dimensional Au(111) quantum films grown on W(110) does not deviate from the expected free-electron-like behavior, its nonequilibrium energy-momentum dispersion probed by time- and angle-resolved photoemission exhibits a remarkable kink above the Fermi level due to a significant enhancement of the effective mass. The kink is pronounced for certain thicknesses of the Au quantum well and vanishes in the very thin limit. We identify the kink as induced by the coupling between the Au(111) surface state and emergent quantum-well states which probe directly the buried gold-tungsten interface. The signatures of the coupling are further revealed by our time-resolved measurements which show that surface state and quantum-well states thermalize together behaving as dynamically locked electron populations. In particular, relaxation of hot carriers following laser excitation is similar for both surface state and quantum-well states and much slower than expected for a bulk metallic system. The influence of quantum confinement on the interplay between elementary scattering processes of the electrons at the surface and ultrafast carrier transport in the direction perpendicular to the surface is shown to be the reason for the slow electron dynamics. KW - AG KW - Flims Y1 - 2020 U6 - https://doi.org/10.1103/PhysRevResearch.2.013343 SN - 0031-9007 VL - 2 IS - 1 SP - 1 EP - 9 PB - American Physical Society CY - Ridge, NY ER - TY - JOUR A1 - Jones, Benjamin M. A1 - Arp, Christopher D. A1 - Grosse, Guido A1 - Nitze, Ingmar A1 - Lara, Mark J. A1 - Whitman, Matthew S. A1 - Farquharson, Louise M. A1 - Kanevskiy, Mikhail A1 - Parsekian, Andrew D. A1 - Breen, Amy L. A1 - Ohara, Nori A1 - Rangel, Rodrigo Correa A1 - Hinkel, Kenneth M. T1 - Identifying historical and future potential lake drainage events on the western Arctic coastal plain of Alaska JF - Permafrost and Periglacial Processes N2 - Arctic lakes located in permafrost regions are susceptible to catastrophic drainage. In this study, we reconstructed historical lake drainage events on the western Arctic Coastal Plain of Alaska between 1955 and 2017 using USGS topographic maps, historical aerial photography (1955), and Landsat Imagery (ca. 1975, ca. 2000, and annually since 2000). We identified 98 lakes larger than 10 ha that partially (>25% of area) or completely drained during the 62-year period. Decadal-scale lake drainage rates progressively declined from 2.0 lakes/yr (1955-1975), to 1.6 lakes/yr (1975-2000), and to 1.2 lakes/yr (2000-2017) in the ~30,000-km(2) study area. Detailed Landsat trend analysis between 2000 and 2017 identified two years, 2004 and 2006, with a cluster (five or more) of lake drainages probably associated with bank overtopping or headward erosion. To identify future potential lake drainages, we combined the historical lake drainage observations with a geospatial dataset describing lake elevation, hydrologic connectivity, and adjacent lake margin topographic gradients developed with a 5-m-resolution digital surface model. We identified ~1900 lakes likely to be prone to drainage in the future. Of the 20 lakes that drained in the most recent study period, 85% were identified in this future lake drainage potential dataset. Our assessment of historical lake drainage magnitude, mechanisms and pathways, and identification of potential future lake drainages provides insights into how arctic lowland landscapes may change and evolve in the coming decades to centuries. KW - Arctic lakes KW - drained lake basins KW - lake drainage KW - permafrost regions KW - thermokarst lakes Y1 - 2020 U6 - https://doi.org/10.1002/ppp.2038 VL - 31 IS - 1 SP - 110 EP - 127 PB - Wiley CY - New York ER - TY - JOUR A1 - Zimmermann, Marc A1 - Stomps, Benjamin René Harald A1 - Schulte-Osseili, Christine A1 - Grigoriev, Dmitry A1 - Ewen, Dirk A1 - Morgan, Andrew A1 - Böker, Alexander T1 - Organic dye anchor peptide conjugates as an advanced coloring agent for polypropylene yarn JF - Textile Research Journal N2 - Polypropylene as one of the world's top commodity polymers is also widely used in the textile industry. However, its non-polar nature and partially crystalline structure significantly complicate the process of industrial coloring of polypropylene. Currently, textiles made of polypropylene or with a significant proportion of polypropylene are dyed under quite harsh conditions, including the use of high pressures and temperatures, which makes this process energy intensive. This research presents a three-step synthesis of coloring agents, capable of adhering onto synthetic polypropylene yarns without harsh energy-consuming conditions. This is possible by encapsulation of organic pigments using trimethoxyphenylsilane, introduction of surface double bonds via modification of the silica shell with trimethoxysilylpropylmethacrylate and final attachment of highly adhesive anchor peptides using thiol-ene chemistry. We demonstrate the applicability of this approach by dyeing polypropylene yarns in a simple process under ambient conditions after giving a step-by-step guide for the synthesis of these new dyeing agents. Finally, the successful dyeing of the yarns is visualized, and its practicability is discussed. KW - anchor peptides KW - organic dye pigments KW - coloring agents KW - polypropylene KW - yarns Y1 - 2020 U6 - https://doi.org/10.1177/0040517520932231 SN - 0040-5175 SN - 1746-7748 VL - 91 IS - 1-2 SP - 28 EP - 39 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Smetanová, Anna A1 - Müller, Anne A1 - Zargar, Morteza A1 - Suleiman, Mohamed A. A1 - Gholami, Faraz Rabei A1 - Mousavi, Maryam T1 - Mesoscale mapping of sediment source hotspots for dam sediment management in data-sparse semi-arid catchments JF - Water N2 - Land degradation and water availability in semi-arid regions are interdependent challenges for management that are influenced by climatic and anthropogenic changes. Erosion and high sediment loads in rivers cause reservoir siltation and decrease storage capacity, which pose risk on water security for citizens, agriculture, and industry. In regions where resources for management are limited, identifying spatial-temporal variability of sediment sources is crucial to decrease siltation. Despite widespread availability of rigorous methods, approaches simplifying spatial and temporal variability of erosion are often inappropriately applied to very data sparse semi-arid regions. In this work, we review existing approaches for mapping erosional hotspots, and provide an example of spatial-temporal mapping approach in two case study regions. The barriers limiting data availability and their effects on erosion mapping methods, their validation, and resulting prioritization of leverage management areas are discussed. KW - reservoir siltation KW - water security KW - water management KW - data sharing KW - spatial-temporal KW - erosion hotspots KW - mapping KW - global datasets KW - mesoscale KW - leverage areas Y1 - 2020 U6 - https://doi.org/10.3390/w12020396 SN - 2073-4441 VL - 12 IS - 2 SP - 1 EP - 24 PB - MDPI CY - Basel ER - TY - GEN A1 - Poch, Olivier A1 - Istiqomah, Istiqomah A1 - Quirico, Eric A1 - Beck, Pierre A1 - Schmitt, Bernard A1 - Theulé, Patrice A1 - Faure, Alexandre A1 - Hily-Blant, Pierre A1 - Bonal, Lydie A1 - Kappel, David T1 - Ammonium salts are a reservoir of nitrogen on a cometary nucleus and possibly on some asteroids T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - The measured nitrogen-to-carbon ratio in comets is lower than for the Sun, a discrepancy which could be alleviated if there is an unknown reservoir of nitrogen in comets. The nucleus of comet 67P/Churyumov-Gerasimenko exhibits an unidentified broad spectral reflectance feature around 3.2 micrometers, which is ubiquitous across its surface. On the basis of laboratory experiments, we attribute this absorption band to ammonium salts mixed with dust on the surface. The depth of the band indicates that semivolatile ammonium salts are a substantial reservoir of nitrogen in the comet, potentially dominating over refractory organic matter and more volatile species. Similar absorption features appear in the spectra of some asteroids, implying a compositional link between asteroids, comets, and the parent interstellar cloud. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1389 KW - resolution infrared-spectroscopy KW - ice absorption features KW - young stellar objects KW - exposed water ice KW - MU-M KW - bidirectional reflectance KW - murchison meteorite KW - interstellar ice KW - spectra KW - surface Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-513751 SN - 1866-8372 N1 - This secondary publication was withdrawn for copyright reasons. IS - 6483 ER - TY - JOUR A1 - Poch, Olivier A1 - Istiqomah, Istiqomah A1 - Quirico, Eric A1 - Beck, Pierre A1 - Schmitt, Bernard A1 - Theulé, Patrice A1 - Faure, Alexandre A1 - Hily-Blant, Pierre A1 - Bonal, Lydie A1 - Kappel, David T1 - Ammonium salts are a reservoir of nitrogen on a cometary nucleus and possibly on some asteroids JF - Science N2 - The measured nitrogen-to-carbon ratio in comets is lower than for the Sun, a discrepancy which could be alleviated if there is an unknown reservoir of nitrogen in comets. The nucleus of comet 67P/Churyumov-Gerasimenko exhibits an unidentified broad spectral reflectance feature around 3.2 micrometers, which is ubiquitous across its surface. On the basis of laboratory experiments, we attribute this absorption band to ammonium salts mixed with dust on the surface. The depth of the band indicates that semivolatile ammonium salts are a substantial reservoir of nitrogen in the comet, potentially dominating over refractory organic matter and more volatile species. Similar absorption features appear in the spectra of some asteroids, implying a compositional link between asteroids, comets, and the parent interstellar cloud. KW - resolution infrared-spectroscopy KW - ice absorption features KW - young stellar objects KW - exposed water ice KW - MU-M KW - bidirectional reflectance KW - murchison meteorite KW - interstellar ice KW - spectra KW - surface Y1 - 2020 U6 - https://doi.org/10.1126/science.aaw7462 SN - 1095-9203 SN - 0036-8075 VL - 367 IS - 6483 SP - 1 EP - 8 PB - AAAS, American Association for the Advancement of Science CY - Washington, DC ER - TY - JOUR A1 - Vyse, Stuart Andrew A1 - Semiromi, Majid Taie A1 - Lischeid, Gunnar A1 - Merz, Christoph T1 - Characterizing hydrological processes within kettle holes using stable water isotopes in the Uckermark of northern Brandenburg, Germany JF - Hydrological Processes N2 - Understanding the hydrologic connectivity between kettle holes and shallow groundwater, particularly in reaction to the highly variable local meteorological conditions, is of paramount importance for tracing water in a hydro(geo)logically complex landscape and thus for integrated water resource management. This article is aimed at identifying the dominant hydrological processes affecting the kettle holes' water balance and their interactions with the shallow groundwater domain in the Uckermark region, located in the north-east of Germany. For this reason, based on the stable isotopes of oxygen (delta O-18) and hydrogen (delta H-2), an isotopic mass balance model was employed to compute the evaporative loss of water from the kettle holes from February to August 2017. Results demonstrated that shallow groundwater inflow may play the pivotal role in the processes taking part in the hydrology of the kettle holes in the Uckermark region. Based on the calculated evaporation/inflow (E/I) ratios, most of the kettle holes (86.7%) were ascertained to have a partially open, flow-through-dominated system. Moreover, we identified an inverse correlation between E/I ratios and the altitudes of the kettle holes. The same holds for electrical conductivity (EC) and the altitudes of the kettle holes. In accordance with the findings obtained from this study, a conceptual model explaining the interaction between the shallow groundwater and the kettle holes of Uckermark was developed. The model exhibited that across the highest altitudes, the recharge kettle holes are dominant, where a lower ratio of E/I and a lower EC was detected. By contrast, the lowest topographical depressions represent the discharge kettle holes, where a higher ratio of E/I and EC could be identified. The kettle holes existing in between were categorized as flow-through kettle holes through which the recharge takes place from one side and discharge from the other side. KW - evaporation KW - groundwater inflow KW - kettle hole KW - stable water isotope KW - surface–groundwater interactions Y1 - 2020 U6 - https://doi.org/10.1002/hyp.13699 SN - 0885-6087 SN - 1099-1085 VL - 34 IS - 8 SP - 1868 EP - 1887 PB - Wiley CY - New York ER - TY - JOUR A1 - Yamazaki, Yosuke A1 - Wendt, Vivien A1 - Miyoshi, Y. A1 - Stolle, Claudia A1 - Siddiqui, Tarique Adnan A1 - Kervalishvili, Guram N. A1 - Laštovička, J. A1 - Kozubek, M. A1 - Ward, W. A1 - Themens, D. R. A1 - Kristoffersen, S. A1 - Alken, Patrick T1 - September 2019 Antarctic sudden stratospheric warming BT - Quasi-6-Day wave burst and ionospheric effects JF - Geophysical Research Letters N2 - An exceptionally strong stationary planetary wave with Zonal Wavenumber 1 led to a sudden stratospheric warming (SSW) in the Southern Hemisphere in September 2019. Ionospheric data from European Space Agency's Swarm satellite constellation mission show prominent 6-day variations in the dayside low-latitude region at this time, which can be attributed to forcing from the middle atmosphere by the Rossby normal mode "quasi-6-day wave" (Q6DW). Geopotential height measurements by the Microwave Limb Sounder aboard National Aeronautics and Space Administration's Aura satellite reveal a burst of global Q6DW activity in the mesosphere and lower thermosphere during the SSW, which is one of the strongest in the record. The Q6DW is apparently generated in the polar stratosphere at 30-40 km, where the atmosphere is unstable due to strong vertical wind shear connected with planetary wave breaking. These results suggest that an Antarctic SSW can lead to ionospheric variability through wave forcing from the middle atmosphere. Plain Language Summary: A sudden stratospheric warming (SSW) is an extreme wintertime polar meteorological phenomenon occurring mostly over the Arctic region. Studies have shown that Arctic SSW can influence the entire atmosphere. In September 2019, a rare SSW event occurred in the Antarctic region, providing an opportunity to investigate its broader impact on the whole atmosphere. We present observations from the middle atmosphere and ionosphere during this event, noting unusually strong wave activity throughout this region. Our results suggest that an Antarctic SSW can have a significant impact on the whole atmosphere system similar to those due to Arctic events. KW - Rossby-normal modes KW - nonumiform background configuration KW - total electron-content KW - large-scale KW - planetary-waves KW - 5-day waves KW - equatorial electrojet KW - lower thermosphere KW - symmetric modes KW - 6.5-Day wave Y1 - 2020 U6 - https://doi.org/10.1029/2019GL086577 SN - 0094-8276 SN - 1944-8007 VL - 47 IS - 1 SP - 1 EP - 12 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Masigol, Hossein A1 - Khodaparast, Seyed Akbar A1 - Mostowfizadeh-Ghalamfarsa, Reza A1 - Rojas-Jimenez, Keilor A1 - Woodhouse, Jason Nicholas A1 - Neubauer, Darshan A1 - Grossart, Hans-Peter T1 - Taxonomical and functional diversity of Saprolegniales in Anzali lagoon, Iran JF - Aquatic Ecology N2 - Studies on the diversity, distribution and ecological role of Saprolegniales (Oomycota) in freshwater ecosystems are currently receiving attention due to a greater understanding of their role in carbon cycling in various aquatic ecosystems. In this study, we characterized several Saprolegniales species isolated from Anzali lagoon, Gilan province, Iran, using morphological and molecular methods. Four species of Saprolegnia were identified, including S. anisospora and S. diclina as first reports for Iran, as well as Achlya strains, which were closely related to A. bisexualis, A. debaryana and A. intricata. Evaluation of the ligno-, cellulo- and chitinolytic activities was performed using plate assay methods. Most of the Saprolegniales isolates were obtained in autumn, and nearly 50% of the strains showed chitinolytic and cellulolytic activities. However, only a few Saprolegniales strains showed lignolytic activities. This study has important implications for better understanding the ecological niche of oomycetes, and to differentiate them from morphologically similar, but functionally different aquatic fungi in freshwater ecosystems. KW - Achlya KW - Saprolegnia KW - aquatic ecosystems KW - carbon cycling KW - polymer degradation KW - Saprolegniaceae KW - Achlyaceae Y1 - 2020 U6 - https://doi.org/10.1007/s10452-019-09745-w SN - 1573-5125 SN - 1386-2588 VL - 54 IS - 1 SP - 323 EP - 336 PB - Springer Science CY - Dordrecht ER - TY - CHAP A1 - Grum, Marcus A1 - Blunk, Oliver A1 - Rojahn, Marcel A1 - Fettke, Peter A1 - Gronau, Norbert T1 - Research challenges of knowledge modelling and the outline of a research agenda T2 - Knowledge in digital age : IFKAD 2020 KW - knowledge management KW - process modelling KW - research challenges Y1 - 2020 SN - 978-88-96687-13-0 SN - 2280-787X PB - The Arts of Business Institute CY - Matera, Italy ER - TY - JOUR A1 - Schué, Emmanuelle A1 - Kopyshev, Alexey A1 - Lutz, Jean-François A1 - Börner, Hans G. T1 - Molecular bottle brushes with positioned selenols BT - Extending the toolbox of oxidative single polymer chain folding with conformation analysis by atomic force microscopy JF - Journal of Polymer Science N2 - A synthesis route to controlled and dynamic single polymer chain folding is reported. Sequence-controlled macromolecules containing precisely located selenol moieties within a polymer chain are synthesized. Oxidation of selenol functionalities lead to diselenide bridges and induces controlled intramolecular crosslinking to generate single chain collapse. The cyclization process is successfully characterized by SEC as well as by H-1 NMR and 2D HSQC NMR spectroscopies. In order to gain insight on the molecular level to reveal the degree of structural control, the folded polymers are transformed into folded molecular brushes that are known to be visualizable as single molecule structures by AFM. The "grafting onto" approach is performed by using triazolinedione-diene reaction to graft the side chain polymers. A series of folded molecular brushes as well as the corresponding linear controls are synthesized. AFM visualization is proving the cyclization of the folded backbone by showing globular objects, where non-folded brushes show typical worm-like structures. (C) 2019 The Authors. Journal of Polymer Science published by Wiley Periodicals, Inc. KW - atomic force microscopy (AFM) KW - diselenide KW - grafted polymers KW - molecular bottle brushes KW - sequence-controlled polymers KW - single chain folding Y1 - 2020 U6 - https://doi.org/10.1002/pola.29496 SN - 2642-4169 VL - 58 IS - 1 SP - 154 EP - 162 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Kuhlicke, Christian A1 - Masson, Torsten A1 - Kienzler, Sarah A1 - Sieg, Tobias A1 - Thieken, Annegret A1 - Kreibich, Heidi T1 - Multiple flood experiences and social resilience BT - Findings from three surveys on households and companies exposed to the 2013 flood in Germany JF - Weather, Climate, and Society N2 - Previous studies have explored the consequences of flood events for exposed households and companies by focusing on single flood events. Less is known about the consequences of experiencing repeated flood events for the resilience of households and companies. In this paper, we therefore explore how multiple floods experience affects the resilience of exposed households and companies. Resilience was made operational through individual appraisals of households and companies' ability to withstand and recover from material as well as health and psychological impacts of the 2013 flood in Germany. The paper is based on three different datasets including more than 2000 households and 300 companies that were affected by the 2013 flood. The surveys revealed that the resilience of households seems to increase, but only with regard to their subjectively appraised ability to withstand impacts on mobile goods and equipment (e.g., cars, TV, and radios). In regard to the ability of households to withstand overall financial consequences of repetitive floods, evidence for nonlinear (quadratic) trends can be found. With regard to psychological and health-related consequences, the findings are mixed but provide tentative evidence for eroding resilience among households. Companies' resilience increased with respect to material assets but appears to decrease with respect to ability to recover. We conclude by arguing that clear and operational definitions of resilience are required so that evidence-based resilience baselines can be established to assess whether resilience is eroding or improving over time. KW - social science KW - Europe Y1 - 2020 U6 - https://doi.org/10.1175/WCAS-D-18-0069.1 SN - 1948-8327 SN - 1948-8335 VL - 12 IS - 1 SP - 63 EP - 88 PB - American Meteorological Society CY - Boston ER - TY - JOUR A1 - Dwi Putra, Sulistyo Emantoko A1 - Reichetzeder, Christoph A1 - Hasan, Ahmed Abdallah Abdalrahman Mohamed A1 - Slowinski, Torsten A1 - Chu, Chang A1 - Krämer, Bernhard K. A1 - Kleuser, Burkhard A1 - Hocher, Berthold T1 - Being born large for gestational age is associated with increased global placental DNA methylation JF - Scientific Reports N2 - Being born small (SGA) or large for gestational age (LGA) is associated with adverse birth outcomes and metabolic diseases in later life of the offspring. It is known that aberrations in growth during gestation are related to altered placental function. Placental function is regulated by epigenetic mechanisms such as DNA methylation. Several studies in recent years have demonstrated associations between altered patterns of DNA methylation and adverse birth outcomes. However, larger studies that reliably investigated global DNA methylation are lacking. The aim of this study was to characterize global placental DNA methylation in relationship to size for gestational age. Global DNA methylation was assessed in 1023 placental samples by LC-MS/MS. LGA offspring displayed significantly higher global placental DNA methylation compared to appropriate for gestational age (AGA; p<0.001). ANCOVA analyses adjusted for known factors impacting on DNA methylation demonstrated an independent association between placental global DNA methylation and LGA births (p<0.001). Tertile stratification according to global placental DNA methylation levels revealed a significantly higher frequency of LGA births in the third tertile. Furthermore, a multiple logistic regression analysis corrected for known factors influencing birth weight highlighted an independent positive association between global placental DNA methylation and the frequency of LGA births (p=0.001). KW - fetal origins hypothesis KW - birth weight KW - repetitive elements KW - glucocorticoid receptor KW - nutrient transport KW - growth restriction KW - later health KW - pregnancy KW - genes KW - patterns Y1 - 2020 U6 - https://doi.org/10.1038/s41598-020-57725-0 SN - 2045-2322 VL - 10 IS - 1 SP - 1 EP - 10 PB - Springer Nature CY - London ER - TY - JOUR A1 - Foster, William J. A1 - Garvie, Christopher L. A1 - Weiss, Anna M. A1 - Muscente, A. Drew A1 - Aberhan, Martin A1 - Counts, John W. A1 - Martindale, Rowan C. T1 - Resilience of marine invertebrate communities during the early Cenozoic hyperthermals JF - Scientific Reports N2 - The hyperthermal events of the Cenozoic, including the Paleocene-Eocene Thermal Maximum, provide an opportunity to investigate the potential effects of climate warming on marine ecosystems. Here, we examine the shallow benthic marine communities preserved in the late Cretaceous to Eocene strata on the Gulf Coastal Plain (United States). In stark contrast to the ecological shifts following the end-Cretaceous mass extinction, our data show that the early Cenozoic hyperthermals did not have a long-term impact on the generic diversity nor composition of the Gulf Coastal Plain molluscan communities. We propose that these communities were resilient to climate change because molluscs are better adapted to high temperatures than other taxa, as demonstrated by their physiology and evolutionary history. In terms of resilience, these communities differ from other shallow-water carbonate ecosystems, such as reef communities, which record significant changes during the early Cenozoic hyperthermals. These data highlight the strikingly different responses of community types, i.e., the almost imperceptible response of molluscs versus the marked turnover of foraminifera and reef faunas. The impact on molluscan communities may have been low because detrimental conditions did not devastate the entire Gulf Coastal Plain, allowing molluscs to rapidly recolonise vacated areas once harsh environmental conditions ameliorated. KW - eocene thermal maximum KW - gulf coastal plain KW - climate-change KW - ocean acidification KW - extinction event KW - carbon-cycle KW - heat-stress KW - origination KW - ecosystems KW - diversity Y1 - 2020 U6 - https://doi.org/10.1038/s41598-020-58986-5 SN - 2045-2322 VL - 10 IS - 1 SP - 1 EP - 11 PB - Springer Nature CY - London ER - TY - JOUR A1 - Lang, Judith A1 - Bohn, Patrick A1 - Bhat, Hilal A1 - Jastrow, Holger A1 - Walkenfort, Bernd A1 - Cansiz, Feyza A1 - Fink, Julian A1 - Bauer, Michael A1 - Schumacher, Fabian A1 - Kleuser, Burkhard A1 - Lang, Karl S. T1 - Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease JF - Nature Communications N2 - Macrophages have important protective functions during infection with herpes simplex virus type 1 (HSV-1). However, molecular mechanisms that restrict viral propagation and protect from severe disease are unclear. Here we show that macrophages take up HSV-1 via endocytosis and transport the virions into multivesicular bodies (MVBs). In MVBs, acid ceramidase (aCDase) converts ceramide into sphingosine and increases the formation of sphingosine-rich intraluminal vesicles (ILVs). Once HSV-1 particles reach MVBs, sphingosine-rich ILVs bind to HSV-1 particles, which restricts fusion with the limiting endosomal membrane and prevents cellular infection. Lack of aCDase in macrophage cultures or in Asah1(-/-) mice results in replication of HSV-1 and Asah1(-/-) mice die soon after systemic or intravaginal inoculation. The treatment of macrophages with sphingosine enhancing compounds blocks HSV-1 propagation, suggesting a therapeutic potential of this pathway. In conclusion, aCDase loads ILVs with sphingosine, which prevents HSV-1 capsids from penetrating into the cytosol. KW - immunology KW - infection KW - membrane fusion KW - phagocytosis KW - sphingolipids Y1 - 2020 U6 - https://doi.org/10.1038/s41467-020-15072-8 SN - 2041-1723 VL - 11 IS - 1 SP - 1 EP - 15 PB - Nature Publishing Group UK CY - London ER - TY - JOUR A1 - Jing, Miao A1 - Kumar, Rohini A1 - Heße, Falk A1 - Thober, Stephan A1 - Rakovec, Oldrich A1 - Samaniego, Luis A1 - Attinger, Sabine T1 - Assessing the response of groundwater quantity and travel time distribution to 1.5, 2, and 3 °C global warming in a mesoscale central German basin JF - Hydrology and Earth System Sciences N2 - Groundwater is the biggest single source of high-quality freshwater worldwide, which is also continuously threatened by the changing climate. In this paper, we investigate the response of the regional groundwater system to climate change under three global warming levels (1.5, 2, and 3 ∘C) in a central German basin (Nägelstedt). This investigation is conducted by deploying an integrated modeling workflow that consists of a mesoscale hydrologic model (mHM) and a fully distributed groundwater model, OpenGeoSys (OGS). mHM is forced with climate simulations of five general circulation models under three representative concentration pathways. The diffuse recharges estimated by mHM are used as boundary forcings to the OGS groundwater model to compute changes in groundwater levels and travel time distributions. Simulation results indicate that groundwater recharges and levels are expected to increase slightly under future climate scenarios. Meanwhile, the mean travel time is expected to decrease compared to the historical average. However, the ensemble simulations do not all agree on the sign of relative change. Changes in mean travel time exhibit a larger variability than those in groundwater levels. The ensemble simulations do not show a systematic relationship between the projected change (in both groundwater levels and travel times) and the warming level, but they indicate an increased variability in projected changes with adjusting the enhanced warming level from 1.5 to 3 ∘C. Correspondingly, it is highly recommended to restrain the trend of global warming. KW - climate change impacts KW - hydrological models KW - coupled surface KW - water fluxes KW - catchment KW - recharge KW - dynamics KW - aquifer KW - flow KW - parameterization Y1 - 2020 U6 - https://doi.org/10.5194/hess-24-1511-2020 SN - 1607-7938 SN - 1027-5606 VL - 24 IS - 3 SP - 1511 EP - 1526 PB - Copernicus Publ. CY - Göttingen ER - TY - JOUR A1 - Moradian, Hanieh A1 - Roch, Toralf A1 - Lendlein, Andreas A1 - Gossen, Manfred T1 - mRNA transfection-induced activation of primary human monocytes and macrophages BT - Dependence on carrier system and nucleotide modifcation JF - Scientific reports N2 - Monocytes and macrophages are key players in maintaining immune homeostasis. Identifying strategies to manipulate their functions via gene delivery is thus of great interest for immunological research and biomedical applications. We set out to establish conditions for mRNA transfection in hard-to-transfect primary human monocytes and monocyte-derived macrophages due to the great potential of gene expression from in vitro transcribed mRNA for modulating cell phenotypes. mRNA doses, nucleotide modifications, and different carriers were systematically explored in order to optimize high mRNA transfer rates while minimizing cell stress and immune activation. We selected three commercially available mRNA transfection reagents including liposome and polymer-based formulations, covering different application spectra. Our results demonstrate that liposomal reagents can particularly combine high gene transfer rates with only moderate immune cell activation. For the latter, use of specific nucleotide modifications proved essential. In addition to improving efficacy of gene transfer, our findings address discrete aspects of innate immune activation using cytokine and surface marker expression, as well as cell viability as key readouts to judge overall transfection efficiency. The impact of this study goes beyond optimizing transfection conditions for immune cells, by providing a framework for assessing new gene carrier systems for monocyte and macrophage, tailored to specific applications. KW - sirna transfection KW - mediated delivery KW - gene delivery KW - efficient KW - immunogenicity KW - lipoplexes KW - cells KW - therapeutics KW - polarization KW - pathways Y1 - 2020 U6 - https://doi.org/10.1038/s41598-020-60506-4 SN - 2045-2322 VL - 10 IS - 1 SP - 1 EP - 15 PB - Springer Nature CY - London ER - TY - JOUR A1 - McNulty, Margaret A. A1 - Goupil, Brad A. A1 - Albarado, Diana C. A1 - Castaño-Martinez, Teresa A1 - Ambrosi, Thomas H. A1 - Puh, Spela A1 - Schulz, Tim Julius A1 - Schürmann, Annette A1 - Morrison, Christopher D. A1 - Laeger, Thomas T1 - FGF21, not GCN2, influences bone morphology due to dietary protein restrictions JF - Bone Reports N2 - Background: Dietary protein restriction is emerging as an alternative approach to treat obesity and glucose intolerance because it markedly increases plasma fibroblast growth factor 21 (FGF21) concentrations. Similarly, dietary restriction of methionine is known to mimic metabolic effects of energy and protein restriction with FGF21 as a required mechanism. However, dietary protein has been shown to be required for normal bone growth, though there is conflicting evidence as to the influence of dietary protein restriction on bone remodeling. The purpose of the current study was to evaluate the effect of dietary protein and methionine restriction on bone in lean and obese mice, and clarify whether FGF21 and general control nonderepressible 2 (GCN2) kinase, that are part of a novel endocrine pathway implicated in the detection of protein restriction, influence the effect of dietary protein restriction on bone. Methods: Adult wild-type (WT) or Fgf21 KO mice were fed a normal protein (18 kcal%; CON) or low protein (4 kcal%; LP) diet for 2 or 27 weeks. In addition, adult WT or Gcn2 KO mice were fed a CON or LP diet for 27 weeks. Young New Zealand obese (NZO) mice were placed on high-fat diets that provided protein at control (16 kcal%; CON), low levels (4 kcal%) in a high-carbohydrate (LP/HC) or high-fat (LP/HF) regimen, or on high-fat diets (protein, 16 kcal%) that provided methionine at control (0.86%; CON-MR) or low levels (0.17%; MR) for up to 9 weeks. Long bones from the hind limbs of these mice were collected and evaluated with micro-computed tomography (mu CT) for changes in trabecular and cortical architecture and mass. Results: In WT mice the 27-week LP diet significantly reduced cortical bone, and this effect was enhanced by deletion of Fgf21 but not Gcn2. This decrease in bone did not appear after 2 weeks on the LP diet. In addition, Fgf21 KO mice had significantly less bone than their WT counterparts. In obese NZO mice dietary protein and methionine restriction altered bone architecture. The changes were mediated by FGF21 due to methionine restriction in the presence of cystine, which did not increase plasma FGF21 levels and did not affect bone architecture. Conclusions: This study provides direct evidence of a reduction in bone following long-term dietary protein restriction in a mouse model, effects that appear to be mediated by FGF21. KW - dietary restriction KW - protein restriction KW - FGF21 KW - GCN2 KW - microcomputed tomography Y1 - 2020 U6 - https://doi.org/10.1016/j.bonr.2019.100241 SN - 2352-1872 VL - 12 SP - 1 EP - 10 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Weber, Daniela A1 - Kochlik, Bastian Max A1 - Demuth, Ilja A1 - Steinhagen-Thiessen, Elisabeth A1 - Grune, Tilman A1 - Norman, Kristina T1 - Plasma carotenoids, tocopherols and retinol BT - Association with age in the Berlin Aging Study II JF - Redox Biology N2 - Regular consumption of fruits and vegetables, which is related to high plasma levels of lipid-soluble micro-nutrients such as carotenoids and tocopherols, is linked to lower incidences of various age-related diseases. Differences in lipid-soluble micronutrient blood concentrations seem to be associated with age. Our retrospective analysis included men and women aged 22-37 and 60-85 years from the Berlin Aging Study II. Participants with simultaneously available plasma samples and dietary data were included (n = 1973). Differences between young and old groups were found for plasma lycopene, alpha-carotene, alpha-tocopherol, beta-cryptoxanthin (only in women), and gamma-tocopherol (only in men). beta-Carotene, retinol and lutein/zeaxanthin did not differ between young and old participants regardless of the sex. We found significant associations for lycopene, alpha-carotene (both inverse), alpha-tocopherol, gamma-tocopherol, and beta-carotene (all positive) with age. Adjusting for BMI, smoking status, season, cholesterol and dietary intake confirmed these associations, except for beta-carotene. These micronutrients are important antioxidants and associated with lower incidence of age-related diseases, therefore it is important to understand the underlying mechanisms in order to implement dietary strategies for the prevention of age-related diseases. To explain the lower lycopene and alpha-carotene concentration in older subjects, bioavailability studies in older participants are necessary. KW - carotenoids KW - tocopherols KW - micronutrients KW - age KW - plasma KW - food frequency questionnaire Y1 - 2020 U6 - https://doi.org/10.1016/j.redox.2020.101461 SN - 2213-2317 VL - 32 SP - 1 EP - 8 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Obbard, Darren J. A1 - Shi, Mang A1 - Roberts, Katherine E. A1 - Longdon, Ben A1 - Dennis, Alice B. T1 - A new lineage of segmented RNA viruses infecting animals JF - Virus Evolution N2 - Metagenomic sequencing has revolutionised our knowledge of virus diversity, with new virus sequences being reported faster than ever before. However, virus discovery from metagenomic sequencing usually depends on detectable homology: without a sufficiently close relative, so-called ‘dark’ virus sequences remain unrecognisable. An alternative approach is to use virus-identification methods that do not depend on detecting homology, such as virus recognition by host antiviral immunity. For example, virus-derived small RNAs have previously been used to propose ‘dark’ virus sequences associated with the Drosophilidae (Diptera). Here, we combine published Drosophila data with a comprehensive search of transcriptomic sequences and selected meta-transcriptomic datasets to identify a completely new lineage of segmented positive-sense single-stranded RNA viruses that we provisionally refer to as the Quenyaviruses. Each of the five segments contains a single open reading frame, with most encoding proteins showing no detectable similarity to characterised viruses, and one sharing a small number of residues with the RNA-dependent RNA polymerases of single- and double-stranded RNA viruses. Using these sequences, we identify close relatives in approximately 20 arthropods, including insects, crustaceans, spiders, and a myriapod. Using a more conserved sequence from the putative polymerase, we further identify relatives in meta-transcriptomic datasets from gut, gill, and lung tissues of vertebrates, reflecting infections of vertebrates or of their associated parasites. Our data illustrate the utility of small RNAs to detect viruses with limited sequence conservation, and provide robust evidence for a new deeply divergent and phylogenetically distinct RNA virus lineage. KW - metagenome KW - RNA virus KW - dark virus KW - arthropod KW - RNA interference Y1 - 2020 U6 - https://doi.org/10.1093/ve/vez061 SN - 2057-1577 VL - 6 IS - 1 SP - 1 EP - 10 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Zwaag, Jelle A1 - Horst, Rob ter A1 - Blaženović, Ivana A1 - Stößel, Daniel A1 - Ratter, Jacqueline A1 - Worseck, Josephine M. A1 - Schauer, Nicolas A1 - Stienstra, Rinke A1 - Netea, Mihai G. A1 - Jahn, Dieter A1 - Pickkers, Peter A1 - Kox, Matthijs T1 - Involvement of lactate and pyruvate in the anti-inflammatory effects exerted by voluntary activation of the sympathetic nervous system JF - Metabolites N2 - We recently demonstrated that the sympathetic nervous system can be voluntarily activated following a training program consisting of cold exposure, breathing exercises, and meditation. This resulted in profound attenuation of the systemic inflammatory response elicited by lipopolysaccharide (LPS) administration. Herein, we assessed whether this training program affects the plasma metabolome and if these changes are linked to the immunomodulatory effects observed. A total of 224 metabolites were identified in plasma obtained from 24 healthy male volunteers at six timepoints, of which 98 were significantly altered following LPS administration. Effects of the training program were most prominent shortly after initiation of the acquired breathing exercises but prior to LPS administration, and point towards increased activation of the Cori cycle. Elevated concentrations of lactate and pyruvate in trained individuals correlated with enhanced levels of anti-inflammatory interleukin (IL)-10. In vitro validation experiments revealed that co-incubation with lactate and pyruvate enhances IL-10 production and attenuates the release of pro-inflammatory IL-1 beta and IL-6 by LPS-stimulated leukocytes. Our results demonstrate that practicing the breathing exercises acquired during the training program results in increased activity of the Cori cycle. Furthermore, this work uncovers an important role of lactate and pyruvate in the anti-inflammatory phenotype observed in trained subjects. KW - metabolomics KW - LPS KW - endotoxin KW - pyruvate KW - lactate KW - cytokines KW - inflammation KW - human endotoxemia KW - cori cycle KW - warburg effect Y1 - 2020 U6 - https://doi.org/10.3390/metabo10040148 SN - 2218-1989 VL - 10 IS - 4 SP - 1 EP - 18 PB - MDPI CY - Basel ER - TY - JOUR A1 - Bilbao-Lasa, Peru A1 - Jara Muñoz, Julius A1 - Pedoja, Kevin A1 - Álvarez, Irantzu A1 - Aranburu, Arantza A1 - Iriarte, Eneko A1 - Galparsoro, Ibon T1 - Submerged marine terraces identification and an approach for numerical modeling the sequence formation in the Bay of Biscay (Northeastern Iberian Peninsula) JF - Frontiers in Earth Science N2 - Submerged sequences of marine terraces potentially provide crucial information of past sea-level positions. However, the distribution and characteristics of drowned marine terrace sequences are poorly known at a global scale. Using bathymetric data and novel mapping and modeling techniques, we studied a submerged sequence of marine terraces in the Bay of Biscay with the objective to identify the distribution and morphologies of submerged marine terraces and the timing and conditions that allowed their formation and preservation. To accomplish the objectives a high-resolution bathymetry (5 m) was analyzed using Geographic Information Systems and TerraceM(R). The successive submerged terraces were identified using a Surface Classification Model, which linearly combines the slope and the roughness of the surface to extract fossil sea-cliffs and fossil rocky shore platforms. For that purpose, contour and hillshaded maps were also analyzed. Then, shoreline angles, a geomorphic marker located at the intersection between the fossil sea-cliff and platform, were mapped analyzing swath profiles perpendicular to the isobaths. Most of the submerged strandlines are irregularly preserved throughout the continental shelf. In summary, 12 submerged terraces with their shoreline angles between approximately: -13 m (T1), -30 and -32 m (T2), -34 and 41 m (T3), -44 and -47 m (T4), -49 and 53 m (T5), -55 and 58 m (T6), -59 and 62 m (T7), -65 and 67 m (T8), -68 and 70 m (T9), -74 and -77 m (T10), -83 and -86 m (T11) and -89 and 92 m (T12). Nevertheless, the ones showing the best lateral continuity and preservation in the central part of the shelf are T3, T4, T5, T7, T8, and T10. The age of the terraces has been estimated using a landscape evolution model. To simulate the formation and preservation of submerged terraces three different scenarios: (i) 20-0 ka; (ii) 128-0 ka; and (iii) 128-20 ka, were compared. The best scenario for terrace generation was between 128 and 20 Ka, where T3, T5, and T7 could have been formed. KW - marine terrace KW - submerged sequence KW - digital bathymetric model KW - TerraceM KW - numerical modeling KW - Bay of Biscay Y1 - 2020 U6 - https://doi.org/10.3389/feart.2020.00047 SN - 2296-6463 VL - 8 IS - 47 SP - 1 EP - 20 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Olayide, Priscilla A1 - Large, Annabel A1 - Stridh, Linnea A1 - Rabbi, Ismail A1 - Baldermann, Susanne A1 - Stavolone, Livia A1 - Alexandersson, Erik T1 - Gene expression and metabolite profiling of thirteen Nigerian cassava landraces to elucidate starch and carotenoid composition JF - Agronomy N2 - The prevalence of vitamin A deficiency in sub-Saharan Africa necessitates effective approaches to improve provitamin A content of major staple crops. Cassava holds much promise for food security in sub-Saharan Africa, but a negative correlation between beta-carotene, a provitamin A carotenoid, and dry matter content has been reported, which poses a challenge to cassava biofortification by conventional breeding. To identify suitable material for genetic transformation in tissue culture with the overall aim to increase beta-carotene and maintain starch content as well as better understand carotenoid composition, root and leaf tissues from thirteen field-grown cassava landraces were analyzed for agronomic traits, carotenoid, chlorophyll, and starch content. The expression of five genes related to carotenoid biosynthesis were determined in selected landraces. Analysis revealed a weak negative correlation between starch and beta-carotene content, whereas there was a strong positive correlation between root yield and many carotenoids including beta-carotene. Carotenoid synthesis genes were expressed in both white and yellow cassava roots, but phytoene synthase 2 (PSY2), lycopene-epsilon-cyclase (LCY epsilon), and beta-carotenoid hydroxylase (CHY beta) expression were generally higher in yellow roots. This study identified lines with reasonably high content of starch and beta-carotene that could be candidates for biofortification by further breeding or plant biotechnological means. KW - carotenoid biosynthesis KW - ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) KW - provitamin A KW - biofortification Y1 - 2020 U6 - https://doi.org/10.3390/agronomy10030424 SN - 2073-4395 VL - 10 IS - 3 SP - 1 EP - 16 PB - MDPI CY - Basel ER - TY - JOUR A1 - Amen, Rahma A1 - Nagel, Rebecca A1 - Hedt, Maximilian A1 - Kirschbaum, Frank A1 - Tiedemann, Ralph T1 - Morphological differentiation in African weakly electric fish (genus Campylomormyrus) relates to substrate preferences JF - Evolutionary Ecology N2 - Under an ecological speciation scenario, the radiation of African weakly electric fish (genus Campylomormyrus) is caused by an adaptation to different food sources, associated with diversification of the electric organ discharge (EOD). This study experimentally investigates a phenotype-environment correlation to further support this scenario. Our behavioural experiments showed that three sympatric Campylomormyrus species with significantly divergent snout morphology differentially react to variation in substrate structure. While the short snout species (C. tamandua) exhibits preference to sandy substrate, the long snout species (C. rhynchophorus) significantly prefers a stone substrate for feeding. A third species with intermediate snout size (C. compressirostris) does not exhibit any substrate preference. This preference is matched with the observation that long-snouted specimens probe deeper into the stone substrate, presumably enabling them to reach prey more distant to the substrate surface. These findings suggest that the diverse feeding apparatus in the genus Campylomormyrus may have evolved in adaptation to specific microhabitats, i.e., substrate structures where these fish forage. Whether the parallel divergence in EOD is functionally related to this adaptation or solely serves as a prezygotic isolation mechanism remains to be elucidated. KW - ecological speciation KW - feeding behaviour KW - electric fish KW - trophic apparatus KW - evolutionary ecology Y1 - 2020 U6 - https://doi.org/10.1007/s10682-020-10043-3 SN - 0269-7653 SN - 1573-8477 VL - 34 IS - 3 SP - 427 EP - 437 PB - Springer Science CY - Dordrecht ER - TY - JOUR A1 - Kirchartz, Thomas A1 - Márquez, José A. A1 - Stolterfoht, Martin A1 - Unold, Thomas T1 - Photoluminescence-based characterization of halide perovskites for photovoltaics JF - Advanced Energy Materials N2 - Photoluminescence spectroscopy is a widely applied characterization technique for semiconductor materials in general and halide perovskite solar cell materials in particular. It can give direct information on the recombination kinetics and processes as well as the internal electrochemical potential of free charge carriers in single semiconductor layers, layer stacks with transport layers, and complete solar cells. The correct evaluation and interpretation of photoluminescence requires the consideration of proper excitation conditions, calibration and application of the appropriate approximations to the rather complex theory, which includes radiative recombination, non-radiative recombination, interface recombination, charge transfer, and photon recycling. In this article, an overview is given of the theory and application to specific halide perovskite compositions, illustrating the variables that should be considered when applying photoluminescence analysis in these materials. KW - metal halide perovskites KW - numerical simulations KW - photoluminescence KW - photon recycling Y1 - 2020 U6 - https://doi.org/10.1002/aenm.201904134 SN - 1614-6832 SN - 1614-6840 VL - 10 IS - 26 SP - 1 EP - 21 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Tardif, Delphine A1 - Fluteau, Frédéric A1 - Donnadieu, Yannick A1 - Le Hir, Guillaume A1 - Ladant, Jean-Baptiste A1 - Sepulchre, Pierre A1 - Licht, Alexis A1 - Poblete, Fernando A1 - Dupont-Nivet, Guillaume T1 - The origin of Asian monsoons BT - a modelling perspective JF - Climate of the Past N2 - The Cenozoic inception and development of the Asian monsoons remain unclear and have generated much debate, as several hypotheses regarding circulation patterns at work in Asia during the Eocene have been proposed in the few last decades. These include (a) the existence of modern-like monsoons since the early Eocene; (b) that of a weak South Asian monsoon (SAM) and little to no East Asian monsoon (EAM); or (c) a prevalence of the Intertropical Convergence Zone (ITCZ) migrations, also referred to as Indonesian-Australian monsoon (I-AM). As SAM and EAM are supposed to have been triggered or enhanced primarily by Asian palaeogeographic changes, their possible inception in the very dynamic Eocene palaeogeographic context remains an open question, both in the modelling and field-based communities. We investigate here Eocene Asian climate conditions using the IPSL-CM5A2 (Sepulchre et al., 2019) earth system model and revised palaeogeographies. Our Eocene climate simulation yields atmospheric circulation patterns in Asia substantially different from modern conditions. A large high-pressure area is simulated over the Tethys ocean, which generates intense low tropospheric winds blowing southward along the western flank of the proto-Himalayan-Tibetan plateau (HTP) system. This low-level wind system blocks, to latitudes lower than 10 degrees N, the migration of humid and warm air masses coming from the Indian Ocean. This strongly contrasts with the modern SAM, during which equatorial air masses reach a latitude of 20-25 degrees N over India and southeastern China. Another specific feature of our Eocene simulation is the widespread subsidence taking place over northern India in the midtroposphere (around 5000 m), preventing deep convective updraught that would transport water vapour up to the condensation level. Both processes lead to the onset of a broad arid region located over northern India and over the HTP. More humid regions of high seasonality in precipitation encircle this arid area, due to the prevalence of the Intertropical Convergence Zone (ITCZ) migrations (or Indonesian-Australian monsoon, I-AM) rather than monsoons. Although the existence of this central arid region may partly result from the specifics of our simulation (model dependence and palaeogeographic uncertainties) and has yet to be confirmed by proxy records, most of the observational evidence for Eocene monsoons are located in the highly seasonal transition zone between the arid area and the more humid surroundings. We thus suggest that a zonal arid climate prevailed over Asia before the initiation of monsoons that most likely occurred following Eocene palaeogeographic changes. Our results also show that precipitation seasonality should be used with caution to infer the presence of a monsoonal circulation and that the collection of new data in this arid area is of paramount importance to allow the debate to move forward. KW - earth system model KW - early eocene KW - tibetan plateau KW - climate-change KW - oligocene climate KW - summer monsoon KW - global monsoon KW - ice sheet KW - part 1 KW - China Y1 - 2020 U6 - https://doi.org/10.5194/cp-16-847-2020 SN - 1814-9332 SN - 1814-9324 VL - 16 IS - 3 SP - 847 EP - 865 PB - Copernicus Publications CY - Göttingen ER - TY - JOUR A1 - Cheng, Xin A1 - Zhang, Jie A1 - Kliem, Bernhard A1 - Török, Tibor A1 - Xing, Chen A1 - Zhou, Zhenjun A1 - Inhester, Bernd A1 - Ding, Mingde T1 - Initiation and early kinematic evolution of solar eruptions JF - The Astrophysical Journal N2 - We investigate the initiation and early evolution of 12 solar eruptions, including six active-region hot channel and six quiescent filament eruptions, which were well observed by the Solar Dynamics Observatory, as well as by the Solar Terrestrial Relations Observatory for the latter. The sample includes one failed eruption and 11 coronal mass ejections, with velocities ranging from 493 to 2140 km s(-1). A detailed analysis of the eruption kinematics yields the following main results. (1) The early evolution of all events consists of a slow-rise phase followed by a main-acceleration phase, the height-time profiles of which differ markedly and can be best fit, respectively, by a linear and an exponential function. This indicates that different physical processes dominate in these phases, which is at variance with models that involve a single process. (2) The kinematic evolution of the eruptions tends to be synchronized with the flare light curve in both phases. The synchronization is often but not always close. A delayed onset of the impulsive flare phase is found in the majority of the filament eruptions (five out of six). This delay and its trend to be larger for slower eruptions favor ideal MHD instability models. (3) The average decay index at the onset heights of the main acceleration is close to the threshold of the torus instability for both groups of events (although, it is based on a tentative coronal field model for the hot channels), suggesting that this instability initiates and possibly drives the main acceleration. KW - solar coronal mass ejections KW - stellar coronal mass ejections KW - solar storm Y1 - 2020 U6 - https://doi.org/10.3847/1538-4357/ab886a SN - 1055-6796 SN - 1476-3540 VL - 894 IS - 2 SP - 1 EP - 20 PB - Cambridge Scientific Publishers CY - Cambridge ER - TY - JOUR A1 - García-Benito, Inés A1 - Quarti, Claudio A1 - Queloz, Valentin I. E. A1 - Hofstetter, Yvonne J. A1 - Becker-Koch, David A1 - Caprioglio, Pietro A1 - Neher, Dieter A1 - Orlandi, Simonetta A1 - Cavazzini, Marco A1 - Pozzi, Gianluca A1 - Even, Jacky A1 - Nazeeruddin, Mohammad Khaja A1 - Vaynzof, Yana A1 - Grancini, Giulia T1 - Fluorination of organic spacer impacts on the structural and optical response of 2D perovskites JF - Frontiers in Chemistry N2 - Low-dimensional hybrid perovskites have triggered significant research interest due to their intrinsically tunable optoelectronic properties and technologically relevant material stability. In particular, the role of the organic spacer on the inherent structural and optical features in two-dimensional (2D) perovskites is paramount for material optimization. To obtain a deeper understanding of the relationship between spacers and the corresponding 2D perovskite film properties, we explore the influence of the partial substitution of hydrogen atoms by fluorine in an alkylammonium organic cation, resulting in (Lc)(2)PbI4 and (Lf)(2)PbI4 2D perovskites, respectively. Consequently, optical analysis reveals a clear 0.2 eV blue-shift in the excitonic position at room temperature. This result can be mainly attributed to a band gap opening, with negligible effects on the exciton binding energy. According to Density Functional Theory (DFT) calculations, the band gap increases due to a larger distortion of the structure that decreases the atomic overlap of the wavefunctions and correspondingly bandwidth of the valence and conduction bands. In addition, fluorination impacts the structural rigidity of the 2D perovskite, resulting in a stable structure at room temperature and the absence of phase transitions at a low temperature, in contrast to the widely reported polymorphism in some non-fluorinated materials that exhibit such a phase transition. This indicates that a small perturbation in the material structure can strongly influence the overall structural stability and related phase transition of 2D perovskites, making them more robust to any phase change. This work provides key information on how the fluorine content in organic spacer influence the structural distortion of 2D perovskites and their optical properties which possess remarkable importance for future optoelectronic applications, for instance in the field of light-emitting devices or sensors. KW - fluorinated organic spacer KW - 2D perovskites KW - phase transition KW - temperature dependence KW - excitonic materials Y1 - 2020 U6 - https://doi.org/10.3389/fchem.2019.00946 SN - 2296-2646 VL - 7 SP - 1 EP - 11 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Zhong, Yufei A1 - Causa, Martina A1 - Moore, Gareth John A1 - Krauspe, Philipp A1 - Xiao, Bo A1 - Günther, Florian A1 - Kublitski, Jonas A1 - BarOr, Eyal A1 - Zhou, Erjun A1 - Banerji, Natalie T1 - Sub-picosecond charge-transfer at near-zero driving force in polymer:non-fullerene acceptor blends and bilayers JF - Nature Communications N2 - Organic photovoltaics based on non-fullerene acceptors (NFAs) show record efficiency of 16 to 17% and increased photovoltage owing to the low driving force for interfacial charge-transfer. However, the low driving force potentially slows down charge generation, leading to a tradeoff between voltage and current. Here, we disentangle the intrinsic charge-transfer rates from morphology-dependent exciton diffusion for a series of polymer:NFA systems. Moreover, we establish the influence of the interfacial energetics on the electron and hole transfer rates separately. We demonstrate that charge-transfer timescales remain at a few hundred femtoseconds even at near-zero driving force, which is consistent with the rates predicted by Marcus theory in the normal region, at moderate electronic coupling and at low re-organization energy. Thus, in the design of highly efficient devices, the energy offset at the donor:acceptor interface can be minimized without jeopardizing the charge-transfer rate and without concerns about a current-voltage tradeoff. KW - organic solar cell KW - electron-transfer KW - Donor-Acceptor (DA) interface KW - transfer dynamics KW - donor KW - seperation KW - efficiency KW - impact KW - energy KW - photovoltaics Y1 - 2020 U6 - https://doi.org/10.1038/s41467-020-14549-w SN - 2041-1723 VL - 11 IS - 1 SP - 1 EP - 10 PB - Nature Publishing Group UK CY - London ER - TY - JOUR A1 - Moreno-Romero, Jordi A1 - Probst, Aline V. A1 - Trindade, Inês A1 - Kalyanikrishna, A1 - Engelhorn, Julia A1 - Farrona, Sara T1 - Looking At the Past and Heading to the Future BT - Meeting Summary of the 6th European Workshop on Plant Chromatin 2019 in Cologne, Germany JF - Frontiers in Plant Science N2 - In June 2019, more than a hundred plant researchers met in Cologne, Germany, for the 6th European Workshop on Plant Chromatin (EWPC). This conference brought together a highly dynamic community of researchers with the common aim to understand how chromatin organization controls gene expression, development, and plant responses to the environment. New evidence showing how epigenetic states are set, perpetuated, and inherited were presented, and novel data related to the three-dimensional organization of chromatin within the nucleus were discussed. At the level of the nucleosome, its composition by different histone variants and their specialized histone deposition complexes were addressed as well as the mechanisms involved in histone post-translational modifications and their role in gene expression. The keynote lecture on plant DNA methylation by Julie Law (SALK Institute) and the tribute session to Lars Hennig, honoring the memory of one of the founders of the EWPC who contributed to promote the plant chromatin and epigenetic field in Europe, added a very special note to this gathering. In this perspective article we summarize some of the most outstanding data and advances on plant chromatin research presented at this workshop. KW - EWPC2019 KW - chromatin KW - epigenetics KW - transcription KW - nucleus Y1 - 2020 U6 - https://doi.org/10.3389/fpls.2019.01795 SN - 1664-462X VL - 10 IS - 1795 SP - 1 EP - 12 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Kessler, Katharina A1 - Hornemann, Silke A1 - Rudovich, Natalia A1 - Weber, Daniela A1 - Grune, Tilman A1 - Kramer, Achim A1 - Pfeiffer, Andreas F. H. A1 - Pivovarova-Ramich, Olga T1 - Saliva samples as a tool to study the effect of meal timing on metabolic and inflammatory biomarkers JF - Nutrients N2 - Meal timing affects metabolic regulation in humans. Most studies use blood samples fortheir investigations. Saliva, although easily available and non-invasive, seems to be rarely used forchrononutritional studies. In this pilot study, we tested if saliva samples could be used to studythe effect of timing of carbohydrate and fat intake on metabolic rhythms. In this cross-over trial, 29 nonobese men were randomized to two isocaloric 4-week diets: (1) carbohydrate-rich meals until13:30 and high-fat meals between 16:30 and 22:00 or (2) the inverse order of meals. Stimulated salivasamples were collected every 4 h for 24 h at the end of each intervention, and levels of hormones andinflammatory biomarkers were assessed in saliva and blood. Cortisol, melatonin, resistin, adiponectin, interleukin-6 and MCP-1 demonstrated distinct diurnal variations, mirroring daytime reports inblood and showing significant correlations with blood levels. The rhythm patterns were similar forboth diets, indicating that timing of carbohydrate and fat intake has a minimal effect on metabolicand inflammatory biomarkers in saliva. Our study revealed that saliva is a promising tool for thenon-invasive assessment of metabolic rhythms in chrononutritional studies, but standardisation of sample collection is needed in out-of-lab studies. KW - meal timing KW - saliva KW - circadian clock KW - adiponectin KW - resistin KW - visfatin KW - insulin KW - melatonin KW - cortisol KW - cytokines Y1 - 2020 U6 - https://doi.org/10.3390/nu12020340 SN - 2072-6643 IS - 2 SP - 1 EP - 12 PB - MDPI CY - Basel ER - TY - JOUR A1 - Cao, Xianyong A1 - Tian, Fang A1 - Andreev, Andrei A1 - Anderson, Patricia M. A1 - Lozhkin, Anatoly V. A1 - Bezrukova, Elena A1 - Ni, Jian A1 - Rudaya, Natalia A1 - Stobbe, Astrid A1 - Wieczorek, Mareike A1 - Herzschuh, Ulrike T1 - A taxonomically harmonized and temporally standardized fossil pollen dataset from Siberia covering the last 40 kyr JF - Earth System Science Data N2 - Pollen records from Siberia are mostly absent in global or Northern Hemisphere synthesis works. Here we present a taxonomically harmonized and temporally standardized pollen dataset that was synthesized using 173 palynological records from Siberia and adjacent areas (northeastern Asia, 42-75 degrees N, 50-180 degrees E). Pollen data were taxonomically harmonized, i.e. the original 437 taxa were assigned to 106 combined pollen taxa. Age-depth models for all records were revised by applying a constant Bayesian age-depth modelling routine. The pollen dataset is available as count data and percentage data in a table format (taxa vs. samples), with age information for each sample. The dataset has relatively few sites covering the last glacial period between 40 and 11.5 ka (calibrated thousands of years before 1950 CE) particularly from the central and western part of the study area. In the Holocene period, the dataset has many sites from most of the area, with the exception of the central part of Siberia. Of the 173 pollen records, 81 % of pollen counts were downloaded from open databases (GPD, EPD, PANGAEA) and 10 % were contributions by the original data gatherers, while a few were digitized from publications. Most of the pollen records originate from peatlands (48 %) and lake sediments (33 %). Most of the records (83 %) have >= 3 dates, allowing the establishment of reliable chronologies. The dataset can be used for various purposes, including pollen data mapping (example maps for Larix at selected time slices are shown) as well as quantitative climate and vegetation reconstructions. The datasets for pollen counts and pollen percentages are available at https://doi.org/10.1594/PANGAEA.898616 (Cao et al., 2019a), also including the site information, data source, original publication, dating data, and the plant functional type for each pollen taxa. KW - Late Quaternary vegetation KW - Holocene environmental history KW - eastern continental Asia KW - plant macrofossil data KW - late pleistocene KW - paleoenvironmental records KW - Verkhoyansk mountains KW - climate dynamics KW - glacial maximum KW - Northern Asia Y1 - 2020 U6 - https://doi.org/10.5194/essd-12-119-2020 SN - 1866-3508 SN - 1866-3516 VL - 12 IS - 1 SP - 119 EP - 135 PB - Copernics Publications CY - Katlenburg-Lindau ER - TY - JOUR A1 - Schuck, Bernhard A1 - Schleicher, Anja Maria A1 - Janssen, Christoph A1 - Toy, Virginia G. A1 - Dresen, Georg T1 - Fault zone architecture of a large plate-bounding strike-slip fault BT - A case study from the Alpine Fault, New Zealand JF - Solid Earth N2 - New Zealand's Alpine Fault is a large, platebounding strike-slip fault, which ruptures in large (M-w > 8) earthquakes. We conducted field and laboratory analyses of fault rocks to assess its fault zone architecture. Results reveal that the Alpine Fault Zone has a complex geometry, comprising an anastomosing network of multiple slip planes that have accommodated different amounts of displacement. This contrasts with the previous perception of the Alpine Fault Zone, which assumes a single principal slip zone accommodated all displacement. This interpretation is supported by results of drilling projects and geophysical investigations. Furthermore, observations presented here show that the young, largely unconsolidated sediments that constitute the footwall at shallow depths have a significant influence on fault gouge rheological properties and structure. KW - san andreas fault KW - thickness-displacement relationships KW - central south island KW - Ion-Beam (FIB) KW - internal structure KW - hanging wall KW - Fluid Flow KW - frictional properties KW - weakening mechanisms KW - strain localization Y1 - 2020 U6 - https://doi.org/10.5194/se-11-95-2020 SN - 1869-9529 VL - 11 IS - 1 SP - 95 EP - 124 PB - Copernicus Publications CY - Göttingen ER - TY - JOUR A1 - Huber, Veronika A1 - Krummenauer, Linda A1 - Peña-Ortiz, Cristina A1 - Lange, Stefan A1 - Gasparrini, Antonio A1 - Vicedo-Cabrera, Ana Maria A1 - Garcia-Herrera, Ricardo A1 - Frieler, Katja T1 - Temperature-related excess mortality in German cities at 2 °C and higher degrees of global warming JF - Environmental Research N2 - Background: Investigating future changes in temperature-related mortality as a function of global mean temperature (GMT) rise allows for the evaluation of policy-relevant climate change targets. So far, only few studies have taken this approach, and, in particular, no such assessments exist for Germany, the most populated country of Europe. Methods: We assess temperature-related mortality in 12 major German cities based on daily time-series of all-cause mortality and daily mean temperatures in the period 1993-2015, using distributed-lag non-linear models in a two-stage design. Resulting risk functions are applied to estimate excess mortality in terms of GMT rise relative to pre-industrial levels, assuming no change in demographics or population vulnerability. Results: In the observational period, cold contributes stronger to temperature-related mortality than heat, with overall attributable fractions of 5.49% (95%CI: 3.82-7.19) and 0.81% (95%CI: 0.72-0.89), respectively. Future projections indicate that this pattern could be reversed under progressing global warming, with heat-related mortality starting to exceed cold-related mortality at 3 degrees C or higher GMT rise. Across cities, projected net increases in total temperature-related mortality were 0.45% (95%CI: -0.02-1.06) at 3 degrees C, 1.53% (95%CI: 0.96-2.06) at 4 degrees C, and 2.88% (95%CI: 1.60-4.10) at 5 degrees C, compared to today's warming level of 1 degrees C. By contrast, no significant difference was found between projected total temperature-related mortality at 2 degrees C versus 1 degrees C of GMT rise. Conclusions: Our results can inform current adaptation policies aimed at buffering the health risks from increased heat exposure under climate change. They also allow for the evaluation of global mitigation efforts in terms of local health benefits in some of Germany's most populated cities. KW - temperature-related mortality KW - climate change KW - Future projections KW - Germany KW - global mean temperature Y1 - 2020 U6 - https://doi.org/10.1016/j.envres.2020.109447 SN - 0013-9351 SN - 1096-0953 VL - 186 SP - 1 EP - 10 PB - Elsevier CY - San Diego, California ER - TY - JOUR A1 - Fichtner, Franziska A1 - Olas, Justyna Jadwiga A1 - Feil, Regina A1 - Watanabe, Mutsumi A1 - Krause, Ursula A1 - Hoefgen, Rainer A1 - Stitt, Mark A1 - Lunn, John Edward T1 - Functional features of Trehalose-6-Phosphate Synthase 1 BT - an essential enzyme in Arabidopsis JF - The Plant Cell N2 - Tre6P synthesis by TPS1 is essential for embryogenesis and postembryonic growth in Arabidopsis, and appropriate Suc signaling by Tre6P is dependent on the noncatalytic domains of TPS1. In Arabidopsis (Arabidopsis thaliana), TREHALOSE-6-PHOSPHATE SYNTHASE1 (TPS1) catalyzes the synthesis of the sucrose-signaling metabolite trehalose 6-phosphate (Tre6P) and is essential for embryogenesis and normal postembryonic growth and development. To understand its molecular functions, we transformed the embryo-lethal tps1-1 null mutant with various forms of TPS1 and with a heterologous TPS (OtsA) from Escherichia coli, under the control of the TPS1 promoter, and tested for complementation. TPS1 protein localized predominantly in the phloem-loading zone and guard cells in leaves, root vasculature, and shoot apical meristem, implicating it in both local and systemic signaling of Suc status. The protein is targeted mainly to the nucleus. Restoring Tre6P synthesis was both necessary and sufficient to rescue the tps1-1 mutant through embryogenesis. However, postembryonic growth and the sucrose-Tre6P relationship were disrupted in some complementation lines. A point mutation (A119W) in the catalytic domain or truncating the C-terminal domain of TPS1 severely compromised growth. Despite having high Tre6P levels, these plants never flowered, possibly because Tre6P signaling was disrupted by two unidentified disaccharide-monophosphates that appeared in these plants. The noncatalytic domains of TPS1 ensure its targeting to the correct subcellular compartment and its catalytic fidelity and are required for appropriate signaling of Suc status by Tre6P. KW - cyanobacterial sucrose-phosphatase KW - trehalose 6-phosphate KW - vegetative growth KW - crystal-structure KW - gene-expression KW - thaliana KW - metabolism KW - phosphorylation KW - reveals KW - proteins Y1 - 2020 U6 - https://doi.org/10.1105/tpc.19.00837 SN - 0032-0781 SN - 1471-9053 VL - 32 IS - 6 SP - 1949 EP - 1972 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Stolterfoht, Martin A1 - Grischek, Max A1 - Caprioglio, Pietro A1 - Wolff, Christian Michael A1 - Gutierrez-Partida, Emilio A1 - Peña-Camargo, Francisco A1 - Rothhardt, Daniel A1 - Zhang, Shanshan A1 - Raoufi, Meysam A1 - Wolansky, Jakob A1 - Abdi-Jalebi, Mojtaba A1 - Stranks, Samuel D. A1 - Albrecht, Steve A1 - Kirchartz, Thomas A1 - Neher, Dieter T1 - How to quantify the efficiency potential of neat perovskite films BT - Perovskite semiconductors with an implied efficiency exceeding 28% JF - Advanced Materials N2 - Perovskite photovoltaic (PV) cells have demonstrated power conversion efficiencies (PCE) that are close to those of monocrystalline silicon cells; however, in contrast to silicon PV, perovskites are not limited by Auger recombination under 1-sun illumination. Nevertheless, compared to GaAs and monocrystalline silicon PV, perovskite cells have significantly lower fill factors due to a combination of resistive and non-radiative recombination losses. This necessitates a deeper understanding of the underlying loss mechanisms and in particular the ideality factor of the cell. By measuring the intensity dependence of the external open-circuit voltage and the internal quasi-Fermi level splitting (QFLS), the transport resistance-free efficiency of the complete cell as well as the efficiency potential of any neat perovskite film with or without attached transport layers are quantified. Moreover, intensity-dependent QFLS measurements on different perovskite compositions allows for disentangling of the impact of the interfaces and the perovskite surface on the non-radiative fill factor and open-circuit voltage loss. It is found that potassium-passivated triple cation perovskite films stand out by their exceptionally high implied PCEs > 28%, which could be achieved with ideal transport layers. Finally, strategies are presented to reduce both the ideality factor and transport losses to push the efficiency to the thermodynamic limit. KW - non-radiative interface recombination KW - perovskite solar cells KW - photoluminescence Y1 - 2020 U6 - https://doi.org/10.1002/adma.202000080 SN - 0935-9648 SN - 1521-4095 VL - 32 IS - 17 SP - 1 EP - 10 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Mohammady, M. Hamed A1 - Auffèves, Alexia A1 - Anders, Janet T1 - Energetic footprints of irreversibility in the quantum regime JF - Communications Physics N2 - In classical thermodynamic processes the unavoidable presence of irreversibility, quantified by the entropy production, carries two energetic footprints: the reduction of extractable work from the optimal, reversible case, and the generation of a surplus of heat that is irreversibly dissipated to the environment. Recently it has been shown that in the quantum regime an additional quantum irreversibility occurs that is linked to decoherence into the energy basis. Here we employ quantum trajectories to construct distributions for classical heat and quantum heat exchanges, and show that the heat footprint of quantum irreversibility differs markedly from the classical case. We also quantify how quantum irreversibility reduces the amount of work that can be extracted from a state with coherences. Our results show that decoherence leads to both entropic and energetic footprints which both play an important role in the optimization of controlled quantum operations at low temperature. In classical thermodynamics irreversibility occurs whenever a non-thermal system is brought into contact with a thermal environment. Using quantum trajectories the authors here establish two energetic footprints of quantum irreversible processes, and find that while quantum irreversibility leads to the occurrence of a quantum heat and a reduction of work production, the two are not linked in the same manner as the classical laws of thermodynamics would dictate. KW - entropy production KW - quantum mechanics KW - thermodynamics Y1 - 2020 U6 - https://doi.org/10.1038/s42005-020-0356-9 SN - 2399-3650 VL - 3 IS - 1 SP - 1 EP - 14 PB - Springer Nature CY - London ER - TY - JOUR A1 - Horton, Benjamin P. A1 - Khan, Nicole S. A1 - Cahill, Niamh A1 - Lee, Janice S. H. A1 - Shaw, Timothy A. A1 - Garner, Andra J. A1 - Kemp, Andrew C. A1 - Engelhart, Simon E. A1 - Rahmstorf, Stefan T1 - Estimating global mean sea-level rise and its uncertainties by 2100 and 2300 from an expert survey JF - npj Climate and Atmospheric Science N2 - Sea-level rise projections and knowledge of their uncertainties are vital to make informed mitigation and adaptation decisions. To elicit projections from members of the scientific community regarding future global mean sea-level (GMSL) rise, we repeated a survey originally conducted five years ago. Under Representative Concentration Pathway (RCP) 2.6, 106 experts projected a likely (central 66% probability) GMSL rise of 0.30-0.65 m by 2100, and 0.54-2.15 m by 2300, relative to 1986-2005. Under RCP 8.5, the same experts projected a likely GMSL rise of 0.63-1.32 m by 2100, and 1.67-5.61 m by 2300. Expert projections for 2100 are similar to those from the original survey, although the projection for 2300 has extended tails and is higher than the original survey. Experts give a likelihood of 42% (original survey) and 45% (current survey) that under the high-emissions scenario GMSL rise will exceed the upper bound (0.98 m) of the likely range estimated by the Fifth Assessment Report of the Intergovernmental Panel on Climate Change, which is considered to have an exceedance likelihood of 17%. Responses to open-ended questions suggest that the increases in upper-end estimates and uncertainties arose from recent influential studies about the impact of marine ice cliff instability on the meltwater contribution to GMSL rise from the Antarctic Ice Sheet. KW - projections KW - Greenland KW - consequences KW - climate Y1 - 2020 U6 - https://doi.org/10.1038/s41612-020-0121-5 SN - 2397-3722 VL - 3 IS - 1 SP - 1 EP - 8 PB - Springer Nature CY - London ER - TY - JOUR A1 - Dietze, Elisabeth A1 - Mangelsdorf, Kai A1 - Andreev, Andrei A1 - Karger, Cornelia A1 - Schreuder, Laura T. A1 - Hopmans, Ellen C. A1 - Rach, Oliver A1 - Sachse, Dirk A1 - Wennrich, Volker A1 - Herzschuh, Ulrike T1 - Relationships between low-temperature fires, climate and vegetation during three late glacials and interglacials of the last 430 kyr in northeastern Siberia reconstructed from monosaccharide anhydrides in Lake El’gygytgyn sediments JF - Climate of the Past N2 - Landscapes in high northern latitudes are assumed to be highly sensitive to future global change, but the rates and long-term trajectories of changes are rather uncertain. In the boreal zone, fires are an important factor in climate-vegetation interactions and biogeochemical cycles. Fire regimes are characterized by small, frequent, low-intensity fires within summergreen boreal forests dominated by larch, whereas evergreen boreal forests dominated by spruce and pine burn large areas less frequently but at higher intensities. Here, we explore the potential of the monosaccharide anhydrides (MA) levoglucosan, mannosan and galactosan to serve as proxies of low-intensity biomass burning in glacial-to-interglacial lake sediments from the high northern latitudes. We use sediments from Lake El'gygytgyn (cores PG 1351 and ICDP 5011-1), located in the far north-east of Russia, and study glacial and interglacial samples of the last 430 kyr (marine isotope stages 5e, 6, 7e, 8, 11c and 12) that had different climate and biome configurations. Combined with pollen and non-pollen palynomorph records from the same samples, we assess how far the modern relationships between fire, climate and vegetation persisted during the past, on orbital to centennial timescales. We find that MAs attached to particulates were well-preserved in up to 430 kyr old sediments with higher influxes from low-intensity biomass burning in interglacials compared to glacials. MA influxes significantly increase when summergreen boreal forest spreads closer to the lake, whereas they decrease when tundra-steppe environments and, especially, Sphagnum peatlands spread. This suggests that low-temperature fires are a typical characteristic of Siberian larch forests also on long timescales. The results also suggest that low-intensity fires would be reduced by vegetation shifts towards very dry environments due to reduced biomass availability, as well as by shifts towards peatlands, which limits fuel dryness. In addition, we observed very low MA ratios, which we interpret as high contributions of galactosan and mannosan from biomass sources other than those currently monitored, such as the moss-lichen mats in the understorey of the summergreen boreal forest. Overall, sedimentary MAs can provide a powerful proxy for fire regime reconstructions and extend our knowledge of long-term natural fire-climate-vegetation feedbacks in the high northern latitudes. KW - molecular tracers KW - organic aerosols KW - emission factors KW - carbonaceous aerosols KW - pollen records KW - core PG1351 KW - biomass KW - holocene KW - levoglucosan KW - charcoal Y1 - 2020 U6 - https://doi.org/10.5194/cp-16-799-2020 SN - 1814-9332 SN - 1814-9324 VL - 16 IS - 2 SP - 788 EP - 818 PB - Copernicus Publications CY - Göttingen ER - TY - JOUR A1 - Kuhlicke, Christian A1 - Seebauer, Sebastian A1 - Hudson, Paul A1 - Begg, Chloe A1 - Bubeck, Philip A1 - Dittmer, Cordula A1 - Grothmann, Torsten A1 - Heidenreich, Anna A1 - Kreibich, Heidi A1 - Lorenz, Daniel F. A1 - Masson, Torsten A1 - Reiter, Jessica A1 - Thaler, Thomas A1 - Thieken, Annegret A1 - Bamberg, Sebastian T1 - The behavioral turn in flood risk management, its assumptions and potential implications JF - WIREs Water N2 - Recent policy changes highlight the need for citizens to take adaptive actions to reduce flood-related impacts. Here, we argue that these changes represent a wider behavioral turn in flood risk management (FRM). The behavioral turn is based on three fundamental assumptions: first, that the motivations of citizens to take adaptive actions can be well understood so that these motivations can be targeted in the practice of FRM; second, that private adaptive measures and actions are effective in reducing flood risk; and third, that individuals have the capacities to implement such measures. We assess the extent to which the assumptions can be supported by empirical evidence. We do this by engaging with three intellectual catchments. We turn to research by psychologists and other behavioral scientists which focus on the sociopsychological factors which influence individual motivations (Assumption 1). We engage with economists, engineers, and quantitative risk analysts who explore the extent to which individuals can reduce flood related impacts by quantifying the effectiveness and efficiency of household-level adaptive measures (Assumption 2). We converse with human geographers and sociologists who explore the types of capacities households require to adapt to and cope with threatening events (Assumption 3). We believe that an investigation of the behavioral turn is important because if the outlined assumptions do not hold, there is a risk of creating and strengthening inequalities in FRM. Therefore, we outline the current intellectual and empirical knowledge as well as future research needs. Generally, we argue that more collaboration across intellectual catchments is needed, that future research should be more theoretically grounded and become methodologically more rigorous and at the same time focus more explicitly on the normative underpinnings of the behavioral turn. KW - capacities KW - effectiveness KW - motivation KW - resources KW - risk governance KW - vulnerability Y1 - 2020 U6 - https://doi.org/10.1002/wat2.1418 SN - 2049-1948 VL - 7 IS - 3 SP - 1 EP - 22 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Deng, Zijun A1 - Wang, Weiwei A1 - Xua, Xun A1 - Gould, Oliver E. C. A1 - Kratz, Karl A1 - Ma, Nan A1 - Lendlein, Andreas T1 - Polymeric sheet actuators with programmable bioinstructivity JF - PNAS N2 - Stem cells are capable of sensing and processing environmental inputs, converting this information to output a specific cell lineage through signaling cascades. Despite the combinatorial nature of mechanical, thermal, and biochemical signals, these stimuli have typically been decoupled and applied independently, requiring continuous regulation by controlling units. We employ a programmable polymer actuator sheet to autonomously synchronize thermal and mechanical signals applied to mesenchymal stem cells (MSC5). Using a grid on its underside, the shape change of polymer sheet, as well as cell morphology, calcium (Ca2+) influx, and focal adhesion assembly, could be visualized and quantified. This paper gives compelling evidence that the temperature sensing and mechanosensing of MSC5 are interconnected via intracellular Ca2+. Up-regulated Ca2+ levels lead to a remarkable alteration of histone H3K9 acetylation and activation of osteogenic related genes. The interplay of physical, thermal, and biochemical signaling was utilized to accelerate the cell differentiation toward osteogenic lineage. The approach of programmable bioinstructivity provides a fundamental principle for functional biomaterials exhibiting multifaceted stimuli on differentiation programs. Technological impact is expected in the tissue engineering of periosteum for treating bone defects. KW - reversible shape-memory actuator KW - mesenchymal stem cells KW - calcium influx KW - HDAC1 KW - RUNX2 Y1 - 2020 U6 - https://doi.org/10.1073/pnas.1910668117 SN - 1091-6490 VL - 117 IS - 4 SP - 1895 EP - 1901 PB - National Academy of Sciences CY - Washington, DC ER - TY - JOUR A1 - Stoof-Leichsenring, Kathleen Rosemarie A1 - Pestryakova, Luidmila Agafyevna A1 - Epp, Laura Saskia A1 - Herzschuh, Ulrike T1 - Phylogenetic diversity and environment form assembly rules for Arctic diatom genera BT - a study on recent and ancient sedimentary DNA JF - Journal of Biogeography N2 - Aim This study investigates taxonomic and phylogenetic diversity in diatom genera to evaluate assembly rules for eukaryotic microbes across the Siberian tree line. We first analysed how phylogenetic distance relates to taxonomic richness and turnover. Second, we used relatedness indices to evaluate if environmental filtering or competition influences the assemblies in space and through time. Third, we used distance-based ordination to test which environmental variables shape diatom turnover. Location Yakutia and Taymyria, Russia: we sampled 78 surface sediments and a sediment core, extending to 7,000 years before present, to capture the forest-tundra transition in space and time respectively. Taxon Arctic freshwater diatoms. Methods We applied metabarcoding to retrieve diatom diversity from surface and core sedimentary DNA. The taxonomic assignment binned sequence types (lineages) into genera and created taxonomic (abundance of lineages within different genera) and phylogenetic datasets (phylogenetic distances of lineages within different genera). Results Contrary to our expectations, we find a unimodal relationship between phylogenetic distance and richness in diatom genera. We discern a positive relationship between phylogenetic distance and taxonomic turnover in spatially and temporally distributed diatom genera. Furthermore, we reveal positive relatedness indices in diatom genera across the spatial environmental gradient and predominantly in time slices at a single location, with very few exceptions assuming effects of competition. Distance-based ordination of taxonomic and phylogenetic turnover indicates that lake environment variables, like HCO3- and water depth, largely explain diatom turnover. Main conclusion Phylogenetic and abiotic assembly rules are important in understanding the regional assembly of diatom genera across lakes in the Siberian tree line ecotone. Using a space-time approach we are able to exclude the influence of geography and elucidate that lake environmental variables primarily shape the assemblies. We conclude that some diatom genera have greater capabilities to adapt to environmental changes, whereas others will be putatively replaced or lost due to the displacement of the Arctic tundra biome under recent global warming. KW - ancient sedimentary DNA KW - Arctic lakes KW - assembly rules KW - climate change KW - diatoms KW - environmental filtering KW - phylogenetic diversity KW - Siberian tree line Y1 - 2020 U6 - https://doi.org/10.1111/jbi.13786 SN - 0305-0270 SN - 1365-2699 VL - 47 IS - 5 SP - 1166 EP - 1179 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Kärcher, Oskar A1 - Filstrup, Christopher T. A1 - Brauns, Mario A1 - Tasevska, Orhideja A1 - Patceva, Suzana A1 - Hellwig, Niels A1 - Walz, Ariane A1 - Frank, Karin A1 - Markovic, Danijela T1 - Chlorophyll a relationships with nutrients and temperature, and predictions for lakes across perialpine and Balkan mountain regions JF - Inland Waters N2 - Model-derived relationships between chlorophyll a (Chl-a) and nutrients and temperature have fundamental implications for understanding complex interactions among water quality measures used for lake classification, yet accuracy comparisons of different approaches are scarce. Here, we (1) compared Chl-a model performances across linear and nonlinear statistical approaches; (2) evaluated single and combined effects of nutrients, depth, and temperature as lake surface water temperature (LSWT) or altitude on Chl-a; and (3) investigated the reliability of the best water quality model across 13 lakes from perialpine and central Balkan mountain regions. Chl-a was modelled using in situ water quality data from 157 European lakes; elevation data and LSWT in situ data were complemented by remote sensing measurements. Nonlinear approaches performed better, implying complex relationships between Chl-a and the explanatory variables. Boosted regression trees, as the best performing approach, accommodated interactions among predictor variables. Chl-a-nutrient relationships were characterized by sigmoidal curves, with total phosphorus having the largest explanatory power for our study region. In comparison with LSWT, utilization of altitude, the often-used temperature surrogate, led to different influence directions but similar predictive performances. These results support utilizing altitude in models for Chl-a predictions. Compared to Chl-a observations, Chl-a predictions of the best performing approach for mountain lakes (oligotrophic-eutrophic) led to minor differences in trophic state categorizations. Our findings suggest that both models with LSWT and altitude are appropriate for water quality predictions of lakes in mountain regions and emphasize the importance of incorporating interactions among variables when facing lake management challenges. KW - chlorophyll a KW - nutrients KW - Ohrid-Prespa region KW - perialpine lakes KW - water temperature Y1 - 2020 U6 - https://doi.org/10.1080/20442041.2019.1689768 SN - 2044-2041 SN - 2044-205X VL - 10 IS - 1 SP - 29 EP - 41 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Weise, Hanna A1 - Auge, Harald A1 - Baessler, Cornelia A1 - Bärlund, Ilona A1 - Bennett, Elena M. A1 - Berger, Uta A1 - Bohn, Friedrich A1 - Bonn, Aletta A1 - Borchardt, Dietrich A1 - Brand, Fridolin A1 - Jeltsch, Florian A1 - Joshi, Jasmin Radha A1 - Grimm, Volker T1 - Resilience trinity BT - safeguarding ecosystem functioning and services across three different time horizons and decision contexts JF - Oikos N2 - Ensuring ecosystem resilience is an intuitive approach to safeguard the functioning of ecosystems and hence the future provisioning of ecosystem services (ES). However, resilience is a multi-faceted concept that is difficult to operationalize. Focusing on resilience mechanisms, such as diversity, network architectures or adaptive capacity, has recently been suggested as means to operationalize resilience. Still, the focus on mechanisms is not specific enough. We suggest a conceptual framework, resilience trinity, to facilitate management based on resilience mechanisms in three distinctive decision contexts and time-horizons: 1) reactive, when there is an imminent threat to ES resilience and a high pressure to act, 2) adjustive, when the threat is known in general but there is still time to adapt management and 3) provident, when time horizons are very long and the nature of the threats is uncertain, leading to a low willingness to act. Resilience has different interpretations and implications at these different time horizons, which also prevail in different disciplines. Social ecology, ecology and engineering are often implicitly focussing on provident, adjustive or reactive resilience, respectively, but these different notions of resilience and their corresponding social, ecological and economic tradeoffs need to be reconciled. Otherwise, we keep risking unintended consequences of reactive actions, or shying away from provident action because of uncertainties that cannot be reduced. The suggested trinity of time horizons and their decision contexts could help ensuring that longer-term management actions are not missed while urgent threats to ES are given priority. KW - concepts KW - ecosystems KW - ecosystem services provisioning KW - management KW - resilience Y1 - 2020 U6 - https://doi.org/10.1111/oik.07213 SN - 0030-1299 SN - 1600-0706 VL - 129 IS - 4 SP - 445 EP - 456 PB - Wiley-Blackwell CY - Oxford ER - TY - CHAP A1 - Schenke, Maren A1 - Schjeide, Brit-Maren A1 - Püschel, Gerhard A1 - Seeger, Bettina T1 - Human motor neurons diffentiated from plutipotent stem cells as superior traged cells for botulinum neuotoxin potency testing BT - In: German Pharm-Tox Summit 2020: abstracts of the 86th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) T2 - Naunyn-Schmiedeberg's archives of pharmacology Y1 - 2020 U6 - https://doi.org/10.1007/s00210-020-01828-y SN - 0028-1298 SN - 1432-1912 VL - 393 IS - SUPPL 1 SP - 10 EP - 10 PB - Springer CY - Berlin ; Heidelberg ER - TY - CHAP A1 - Abramova, Olga T1 - Does a smile open all doors? BT - understanding the impact of appearance disclosure on accommodation sharing platforms T2 - Proceedings of the 53rd Hawaii International Conference on System Sciences N2 - Online photographs govern an individual’s choices across a variety of contexts. In sharing arrangements, facial appearance has been shown to affect the desire to collaborate, interest to explore a listing, and even willingness to pay for a stay. Because of the ubiquity of online images and their influence on social attitudes, it seems crucial to be able to control these aspects. The present study examines the effect of different photographic self-disclosures on the provider’s perceptions and willingness to accept a potential co-sharer. The findings from our experiment in the accommodation-sharing context suggest social attraction mediates the effect of photographic self-disclosures on willingness to host. Implications of the results for IS research and practitioners are discussed. KW - The Sharing Economy KW - airbnb KW - online photographs KW - self-disclosure KW - sharing economy KW - social attraction Y1 - 2020 SN - 978-0-9981331-3-3 SP - 831 EP - 840 PB - HICSS Conference Office University of Hawaii at Manoa CY - Honolulu ER - TY - JOUR A1 - Hipp, Lena T1 - Feeling secure vs. being secure? BT - Qualitative evidence on the relationship between labour market institutions and employees’ perceived job security from Germany and the U.S JF - Contemporary social science N2 - How can labour market institutions make workers confident about their economic future? While quantitative studies have repeatedly shown that countries’ labour market regulations and policies are related to variations in workers’ perceived job security, these studies did not explain how these institutions affect workers’ perceptions and expectations. This study seeks to close this gap by analysing qualitative interview data collected on employees in Germany and the U.S. during the great financial crisis (2009–2010). The study's main finding is that policies vary in their effectiveness at making workers feel secure about their jobs. While unemployment assistance can reduce workers’ worries about job loss, dismissal protection does not seem to effectively increase workers’ confidence that their jobs are secure. Overall, employees know relatively little about the policies and regulations that are meant to protect them and have limited trust in their effectiveness. Individual and organisational characteristics seem to be more relevant for employees’ feelings of job security than national-level policies. In particular, comparisons with others who have lower levels of protection increase workers’ perceived security. These insights are particularly important in light of the ongoing changes in the world of work that are making workers’ lives more uncertain and insecure. KW - perceived job insecurity/security KW - U.S. and Germany KW - labour markets policies KW - institutions Y1 - 2020 U6 - https://doi.org/10.1080/21582041.2019.1656816 SN - 2158-2041 SN - 2158-205X VL - 15 IS - 4 SP - 416 EP - 429 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Schaffenroth, Veronika A1 - Casewell, Sarah L. A1 - Schneider, D. A1 - Kilkenny, David A1 - Geier, Stephan A1 - Heber, Ulrich A1 - Irrgang, Andreas A1 - Przybilla, Norbert A1 - Marsh, Thomas R. A1 - Littlefair, Stuart P. A1 - Dhillon, Vik S. T1 - A quantitative in-depth analysis of the prototype sdB plus BD system SDSS J08205+0008 revisited in the Gaia era JF - Monthly notices of the Royal Astronomical Society N2 - Subdwarf B stars are core-helium-burning stars located on the extreme horizontal branch (EHB). Extensive mass loss on the red giant branch is necessary to form them. It has been proposed that substellar companions could lead to the required mass loss when they are engulfed in the envelope of the red giant star. J08205+0008 was the first example of a hot subdwarf star with a close, substellar companion candidate to be found. Here, we perform an in-depth re-analysis of this important system with much higher quality data allowing additional analysis methods. From the higher resolution spectra obtained with ESO-VLT/XSHOOTER, we derive the chemical abundances of the hot subdwarf as well as its rotational velocity. Using the Gaia parallax and a fit to the spectral energy distribution in the secondary eclipse, tight constraints to the radius of the hot subdwarf are derived. From a long-term photometric campaign, we detected a significant period decrease of -3.2(8) x 10(-12) dd(-1). This can be explained by the non-synchronized hot subdwarf star being spun up by tidal interactions forcing it to become synchronized. From the rate of period decrease we could derive the synchronization time-scale to be 4 Myr, much smaller than the lifetime on EHB. By combining all different methods, we could constrain the hot subdwarf to a mass of 0.39-0.50 M-circle dot and a radius of R-sdB = 0.194 +/- 0.008 R-circle dot, and the companion to 0.061-0.071 M-circle dot with a radius of R-comp = 0.092 +/- 0.005 R-circle dot, below the hydrogen-burning limit. We therefore confirm that the companion is most likely a massive brown dwarf. KW - stars: abundances KW - stars: atmospheres KW - stars: fundamental parameters KW - stars: horizontal branch KW - stars: low-mass KW - subdwarfs Y1 - 2020 U6 - https://doi.org/10.1093/mnras/staa3661 SN - 0035-8711 SN - 1365-2966 VL - 501 IS - 3 SP - 3847 EP - 3870 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Olen, Stephanie M. A1 - Bookhagen, Bodo A1 - Strecker, Manfred T1 - Corrigendum to: Olen, Stephanie M.; Bookhagen, Bodo; Strecker, Manfred R. : Role of climate and vegetation density in modulating denudation rates in the Himalaya. - Earth and planetary science letters. - 445 (2016), S. 57 - 67. - doi: https://doi.org/10.1016/j.epsl.2016.03.047 JF - Earth and planetary science letters N2 - Vegetation has long been hypothesized to influence the nature and rates of surface processes. We test the possible impact of vegetation and climate on denudation rates at orogen scale by taking advantage of a pronounced along-strike gradient in rainfall and vegetation density in the Himalaya. We combine 12 new 10Be denudation rates from the Sutlej Valley and 123 published denudation rates from fluvially- dominated catchments in the Himalaya with remotely-sensed measures of vegetation density and rainfall metrics, and with tectonic and lithologic constraints. In addition, we perform topographic analyses to assess the contribution of vegetation and climate in modulating denudation rates along strike. We observe variations in denudation rates and the relationship between denudation and topography along strike that are most strongly controlled by local rainfall amount and vegetation density, and cannot be explained by along-strike differences in tectonics or lithology. A W–E along-strike decrease in denudation rate variability positively correlates with the seasonality of vegetation density (R = 0.95, p < 0.05), and negatively correlates with mean vegetation density (R = −0.84, p < 0.05). Vegetation density modulates the topographic response to changing denudation rates, such that the functional relationship between denudation rate and topographic steepness becomes increasingly linear as vegetation density increases. We suggest that while tectonic processes locally control the pattern of denudation rates across strike of the Himalaya (i.e., S–N), along strike of the orogen (i.e., E–W) climate exerts a measurable influence on how denudation rates scatter around long-term, tectonically-controlled erosion, and on the functional relationship between topography and denudation Y1 - 2020 U6 - https://doi.org/10.1016/j.epsl.2020.116252 SN - 0012-821X SN - 1385-013X VL - 540 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Dimitrova, Ilinka A1 - Koppitz, Jörg T1 - On relative ranks of the semigroup of orientation-preserving transformations on infinite chains JF - Asian-European journal of mathematics N2 - In this paper, we determine the relative rank of the semigroup OP(X) of all orientation-preserving transformations on infinite chains modulo the semigroup O(X) of all order-preserving transformations. KW - Transformation semigroups on infinite chains KW - order-preserving KW - transformations KW - orientation-preserving transformations KW - relative rank Y1 - 2020 U6 - https://doi.org/10.1142/S1793557121501461 SN - 1793-5571 SN - 1793-7183 VL - 14 IS - 08 PB - World Scientific CY - Singapore ER - TY - JOUR A1 - Gryzik, Stefanie A1 - Hoang, Yen A1 - Lischke, Timo A1 - Mohr, Elodie A1 - Venzke, Melanie A1 - Kadner, Isabelle A1 - Pötzsch, Josephine A1 - Groth, Detlef A1 - Radbruch, Andreas A1 - Hutloff, Andreas A1 - Baumgrass, Ria T1 - Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception JF - eLife N2 - Dysregulated cytokine expression by T cells plays a pivotal role in the pathogenesis of autoimmune diseases. However, the identification of the corresponding pathogenic subpopulations is a challenge, since a distinction between physiological variation and a new quality in the expression of protein markers requires combinatorial evaluation. Here, we were able to identify a super-functional follicular helper T cell (Tfh)-like subpopulation in lupus-prone NZBxW mice with our binning approach "pattern recognition of immune cells (PRI)". PRI uncovered a subpopulation of IL-21(+) IFN-gamma(high) PD-1(low) CD40L(high) CXCR5(-) Bcl-6(-) T cells specifically expanded in diseased mice. In addition, these cells express high levels of TNF-alpha and IL-2, and provide B cell help for IgG production in an IL-21 and CD40L dependent manner. This super-functional T cell subset might be a superior driver of autoimmune processes due to a polyfunctional and high cytokine expression combined with Tfh-like properties. Y1 - 2020 U6 - https://doi.org/10.7554/eLife.53226 SN - 2050-084X VL - 9 PB - eLife Sciences Publications CY - Cambridge ER - TY - JOUR A1 - Hartlieb, Matthias A1 - Mansfield, Edward D. H. A1 - Perrier, Sebastien T1 - A guide to supramolecular polymerizations JF - Polymer Chemistry N2 - Supramolecular polymers or fibers are non-covalent assemblies of unimeric building blocks connected by secondary interactions such as hydrogen bonds or pi-pi interactions. Such structures hold enormous potential in the development of future materials, as their non-covalent nature makes them highly modular and adaptive. Within this review we aim to provide a broad overview over the area of linear supramolecular polymers including the different mechanisms of their polymerization as well as methods essential for their characterization. The different non-covalent interactions able to form supramolecular polymers are discussed, and key examples for each species are shown. Particular emphasis is laid on the development of living supramolecular polymerization able to produce fibers with a controlled length and low length dispersity, and even enable the production of supramolecular block copolymers. Another important and very recent field is the development of out-of-equilibrium supramolecular polymers, where the polymerization process can be temporally controlled enabling access to highly adaptive materials. Y1 - 2020 U6 - https://doi.org/10.1039/c9py01342c SN - 1759-9954 SN - 1759-9962 VL - 11 IS - 6 SP - 1083 EP - 1110 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Gholiagha, Sassan A1 - Holzscheiter, Anna A1 - Liese, Andrea T1 - Activating norm collisions BT - interface conflicts in international drug control JF - Global constitutionalism N2 - This article puts forward a constructivist-interpretivist approach to interface conflicts that emphasises how international actors articulate and problematise norm collisions in discursive and social interactions. Our approach is decidedly agency-oriented and follows the Special Issue’s interest in how interface conflicts play out at the micro-level. The article advances several theoretical and methodological propositions on how to identify norm collisions and the conditions under which they become the subject of international debate. Our argument on norm collisions, understood as situations in which actors perceive two norms as incompatible with each other, is threefold. First, we claim that agency matters to the analysis of the emergence, dynamics, management, and effects of norm collisions in international politics. Second, we propose to differentiate between dormant (subjectively perceived) and open norm collisions (intersubjectively shared). Third, we contend that the transition from dormant to open – which we term activation – depends on the existence of certain scope conditions concerning norm quality as well as changes in power structures and actor constellations. Empirically, we study norm collisions in the area of international drug control, presenting the field as one that contains several cases of dormant and open norm collisions, including those that constitute interface conflicts. For our in-depth analysis we have chosen the international discourse on coca leaf chewing. With this case, we not only seek to demonstrate the usefulness of our constructivist-interpretivist approach but also aim to explain under which conditions dormant norm collisions evolve into open collisions and even into interface conflicts. KW - norm collisions KW - contestation KW - discourse KW - agency KW - international KW - drug control Y1 - 2020 U6 - https://doi.org/10.1017/S2045381719000388 SN - 2045-3817 SN - 2045-3825 VL - 9 IS - 2 SP - 290 EP - 317 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Busch, Per-Olof A1 - Heinzel, Mirko Noa A1 - Kempken, Mathies A1 - Liese, Andrea T1 - Mind the gap? BT - comparing de facto and de jure expert authority of international public administrations in financial and agricultural policy JF - Journal of comparative policy analysis : research and practice N2 - Many authors have argued that International Public Administration can influence policy-making through their expert authority. The article compares de jure and de facto expert authority of IPAs to evaluate their conformity. It comparatively assesses the two kinds of authority for five important IPAs (BIS, FAO, IMF, OECD and World Bank) active in agriculture or financial policy. It shows that, on average, de jure and de facto authority seem to conform. At the same time, it demonstrates that gaps between de jure and de facto authority exist at the level of the IPAs, the policy areas and the IPAs’ addressees KW - international public administration KW - comparative KW - expert authority KW - de jure authority KW - de facto authority KW - international organisations Y1 - 2020 U6 - https://doi.org/10.1080/13876988.2020.1820866 SN - 1387-6988 SN - 1572-5448 VL - 24 IS - 3 SP - 230 EP - 253 PB - Taylor & Francis CY - London ER - TY - CHAP A1 - Kuhlmann, Sabine A1 - Seyfried, Markus ED - Vigoda-Gadot, Eran ED - Vashdi, Dana R. T1 - Comparative methods B BT - comparative methods in public administration – the value of looking around T2 - Handbook of research methods in public administration, management and policy N2 - This chapter outlines the relevance and value of comparative approaches and methods in studying Public Administration (PA). It discusses the roots and current developments of comparative research in PA and discusses various methodological venues for cross-country comparisons, such as most similar/dissimilar systems designs, the method of concomitant variation and the difference-in-difference method. Besides the description of these approaches, we highlight their conceptual value for theory-driven empirical comparative research. Drawing on selected pieces of comparative research, the chapter furthermore provides examples for the application of comparative methods in practice presenting empirical findings and highlighting strengths and weaknesses. The chapter finally emphasizes that the methodological development in comparative PA research has by far not yet reached its end, and that some future challenges need to be addressed, such as the issues of causality, generalizability, and mixed-methods approaches. Y1 - 2020 SN - 978-1-78990-347-8 SN - 978-1-78990-348-5 U6 - https://doi.org/10.4337/9781789903485.00017 SP - 181 EP - 196 PB - Edward Elgar Publishing CY - Cheltenham, UK ER - TY - CHAP A1 - Bogumil, Jörg A1 - Kuhlmann, Sabine ED - Tanguy, Gildas ED - Eymeri-Douzans, Jean-Michel T1 - Territorial administration in Germany BT - institutional variants, reforms, and actors at the meso-level of government T2 - Prefects, governors and commissioners : territorial representatives of the state in Europe N2 - This chapter outlines the organization and allocation of functions at the meso-level of government in Germany (states/Länder administrations). Furthermore, we shed light on the carriers and qualification profiles of the top bureaucrats in meso-level administrations. These high-rank territorial administrators/executives—state appointed heads of administrative districts (Regierungspräsidenten) on the one hand, elected heads of county administrations (Landräte) on the other hand—can be regarded as the German ‘equivalents’ of the prefects in countries with a Napoleonic administrative tradition. Finally, we analyse major reforms that have led to (at times, profound) transformations in territorial administrations, raising the question of to what extent alternative models of territorial bundling and coordination functions are sound and sustainable. KW - Germany KW - territorial administration KW - meso-level of government KW - institutional change Y1 - 2020 SN - 978-3-030-59395-7 SN - 978-3-030-59396-4 U6 - https://doi.org/10.1007/978-3-030-59396-4_15 SP - 327 EP - 352 PB - Palgrave Macmillan CY - Cham ER - TY - JOUR A1 - Bouckaert, Geert A1 - Galli, Davide A1 - Kuhlmann, Sabine A1 - Reiter, Renate A1 - van Hecke, Steven T1 - European coronationalism? BT - a hot spot governing a pandemic crisis JF - Public administration review N2 - The COVID-19 crisis has shown that European countries remain poorly prepared for dealing and coping with health crises and for responding in a coordinated way to a severe influenza pandemic. Within the European Union, the response to the COVID-19 pandemic has a striking diversity in its approach. By focusing on Belgium, France, Germany, and Italy—countries that represent different models of administrative systems in Europe—the analysis shows that major similarities and convergences have become apparent from a cross-country perspective. Moreover, coping with the crisis has been first and foremost an issue of the national states, whereas the European voice has been weak. Hence, the countries’ immediate responses appear to be corona-nationalistic, which we label “coronationalism.” This essay shows the extent to which the four countries adopted different crisis management strategies and which factors explain this variance, with a special focus on their institutional settings and administrative systems. Y1 - 2020 U6 - https://doi.org/10.1111/puar.13242 SN - 0033-3352 SN - 1540-6210 VL - 80 IS - 5 SP - 765 EP - 773 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Covi, Giovanni A1 - Eydam, Ulrich T1 - Correction to: End of the sovereign-bank doom loop in the European Union? BT - the Bank Recovery and Resolution Directive JF - Journal of evolutionary economics Y1 - 2018 U6 - https://doi.org/10.1007/s00191-018-0577-1 SN - 0936-9937 SN - 1432-1386 N1 - Correction to: https://doi.org/10.1007/s00191-018-0576-2 VL - 30 IS - 1 SP - 31 EP - 38 PB - Springer CY - New York ER - TY - GEN A1 - Rodríguez Sillke, Yasmina A1 - Schumann, Michael A1 - Lissner, Donata A1 - Branchi, Frederica A1 - Glauben, Rainer A1 - Siegmund, Britta T1 - Small intestinal inflammation but not colitis drives pro-inflammatory nutritional antigen-specific T-cell response T2 - Journal of Crohn's and Colitis N2 - Background: Inflammatory bowel disease (IBD) represents a dysregulation of the mucosal immune system. The pathogenesis of Crohn’s disease (CD) and ulcerative colitis (UC) is linked to the loss of intestinal tolerance and barrier function. The healthy mucosal immune system has previously been shown to be inert against food antigens. Since the small intestine is the main contact surface for antigens and therefore the immunological response, the present study served to analyse food-antigen-specific T cells in the peripheral blood of IBD patients. Methods: Peripheral blood mononuclear cells of CD, with an affected small intestine, and UC (colitis) patients, either active or in remission, were stimulated with the following food antigens: gluten, soybean, peanut and ovalbumin. Healthy controls and celiac disease patients were included as controls. Antigen-activated CD4+ T cells in the peripheral blood were analysed by a magnetic enrichment of CD154+ effector T cells and a cytometric antigen-reactive T-cell analysis (‘ARTE’ technology) followed by characterisation of the ef- fector response. Results: The effector T-cell response of antigen-specific T cells were compared between CD with small intestinal inflammation and UC where inflammation was restricted to the colon. Among all tested food antigens, the highest frequency of antigen-specific T cells (CD4+CD154+) was found for gluten. Celiac disease patients were included as control, since gluten has been identified as the disease- causing antigen. The highest frequency of gluten antigen-specific T cells was revealed in active CD when compared with UC, celiac disease on a gluten-free diet (GFD) and healthy controls. Ovalbuminspecific T cells were almost undetectable, whereas the reaction to soybean and peanut was slightly higher. But again, the strong- est reaction was observed in CD with small intestinal involvement compared with UC. Remarkably, in celiac disease on a GFD only antigen-specific cells for gluten were detected. These gluten-specific T cells were characterised by up-regulation of the pro-inflammatory cytokines IFN-γ, IL-17A and TNF-α. IFN-g was exclusively elevated in CD patients with active disease. Gluten-specific T-cells expressing IL-17A were increased in all IBD patients. Furthermore, T cells of CD patients, independent of disease activity, revealed a high expression of the pro-inflammatory cytokine TNF-α. Conclusion: The ‘ARTE’-technique allows to analyse and quantify food antigen specific T cells in the peripheral blood of IBD patients indicating a potential therapeutic insight. These data provide evidence that small intestinal inflammation in CD is key for the development of a systemic pro-inflammatory effector T-cell response driven by food antigens. Y1 - 2020 U6 - https://doi.org/10.1093/ecco-jcc/jjz203.172 SN - 1873-9946 SN - 1876-4479 VL - 14 SP - S154 EP - S155 PB - Oxford Univ. Press CY - Oxford ER - TY - CHAP A1 - Rungrottheera, Wannarut A1 - Chang, Der-Chen A1 - Schulze, Bert-Wolfgang T1 - The edge calculus of singularity order >3 T2 - Journal of nonlinear and convex analysis : an international journal N2 - We study Mellin pseudo-differential algebras on singular straight cones and manifolds with singularity of order >= 3. Those are necessary to express parametrices of elliptic differential operators with a corresponding cornerdegenerate behavior, and we obtain regularity in weighted spaces. KW - Pseudo-differential algebras KW - symbols KW - singular manifolds KW - Mellin KW - operator calculus Y1 - 2020 SN - 1345-4773 SN - 1880-5221 VL - 21 IS - 2 SP - 387 EP - 401 PB - Yokohama Publishers CY - Yokohama ER - TY - GEN A1 - Moerschbacher, Bruno A1 - Jaworska, Małgorzata A1 - Peter, Martin G. T1 - Obituary of George A.F. Roberts (1939-2018) T2 - Reactive & functional polymers Y1 - 2020 U6 - https://doi.org/10.1016/j.reactfunctpolym.2020.104711 SN - 1381-5148 SN - 1873-166X VL - 156 PB - Elsevier CY - Amsterdam [u.a.] ER -