TY  - JOUR
A1  - Garcia, A. L.
A1  - Steiniger, J.
A1  - Reich, S. C.
A1  - Weickert, M. O.
A1  - Harsch, I.
A1  - Machowetz, A.
A1  - Mohlig, M.
A1  - Spranger, Joachim
A1  - Rudovich, N. N.
A1  - Meuser, F.
A1  - Doerfer, J.
A1  - Katz, N.
A1  - Speth, M.
A1  - Zunft, Hans-Joachim Franz
A1  - Pfeiffer, Andreas F. H.
A1  - Koebnick, Corinna
T1  - Arabinoxylan fibre consumption improved glucose metabolism, but did not affect serum adipokines in subjects with impaired glucose tolerance
JF  - Hormone and metabolic research
N2  - The consumption of arabinoxylan, a soluble fibre fraction, has been shown to improve glycemic control in type 2 diabetic subjects. Soluble dietary fibre may modulate gastrointestinal or adipose tissue hormones regulating food intake. The present study investigated the effects of arabinoxylan consumption on serum glucose, insulin, lipids, leptin, adiponectin and resistin in subjects with impaired glucose tolerance. In a randomized, single-blind, controlled, crossover intervention trial, 11 adults consumed white bread rolls as either placebo or supplemented with 15g arabinoxylan for 6 weeks with a 6-week washout period. Fasting serum glucose, insulin, triglycerides, unesterified fatty acids, apolipoprotein A1 and B, adiponectin, resistin and leptin were assessed before and after intervention. Fasting serum glucose, serum triglycerides and apolipoprotein A-1 were significantly lower during arabinoxylan consumption compared to placebo (p = 0.029, p = 0.047; p = 0.029, respectively). No effects of arabinoxylan were observed for insulin, adiponectin, leptin and resistin as well as for apolipoprotein B, and unesterified fatty acids. In conclusion, the consumption of AX in subjects with impaired glucose tolerance improved fasting serum glucose, and triglycerides. However, this beneficial effect was not accompanied by changes in fasting adipokine concentrations.
KW  - dietary fibre
KW  - arabinoxylan
KW  - adiponectin
KW  - resistin
KW  - leptin
Y1  - 2006
U6  - https://doi.org/10.1055/s-2006-955089
SN  - 0018-5043
VL  - 38
IS  - 2
SP  - 761
EP  - 766
PB  - Thieme
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Sun, Sheng-Yun
A1  - Huang, Jin
A1  - Meng, Min-Jie
A1  - Lu, Jia-Hai
A1  - Hocher, Berthold
A1  - Liu, Kang-Li
A1  - Yang, Qin-He
A1  - Zhu, Xiao-Feng
T1  - Improvement of lipid profile and reduction of body weight by Shan He Jian Fei Granules in high fat diet-induced obese rats
JF  - Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion
N2  - Background: The goal was to study lipid profiles (TG, TC, LDL, HDL), effects on serum leptin, and fat tissue adiponectin, and resistin as well as body weight effects of Shan He Jian Fei Granules (SHJFG) in rats on a high fat diet.
 Methods: Rats were randomly divided into five groups: normal control group fed with normal fat diet, rats on high fat diet receiving low dosage, middle dosage, high dosage of Shan He Jian Fei Granules (SHJFG) as well as a high fat diet group receiving placebo. Rats were treated for 8 weeks. Body weight and naso-anal length of each rat were recorded and Lee's index was calculated. Serum TG, TC, LDL, HDL and leptin concentrations were analyzed. The gene expressions of adiponectin and resistin in adipose tissues were tested by RT-PCR.
 Results: Compared to the high-fat diet group, body weights, Lee's indexes, weight of fat tissues and serum TG, TC, LDL and leptin of SHJFG groups significantly decreased (p<0.05), whereas mRNA expressions of adiponectin and resistin of SHJFG groups significantly increased (p<0.05).
 Conclusions: SHJFG could significantly lower body weight and serum TG, TC, and LDL of obese rats. The effects of SHJFG in lowering leptin synthesis and raising mRNA expression of adiponectin and resistin in fat tissues may act as part of the mechanisms in lowering body weight of obese rats. Further studies are needed to demonstrate whether SHJFG may also reduce overall cardiovascular morbidity and mortality like other lipid lowering drugs.
KW  - obesity
KW  - high-fat diet
KW  - Shan He Jian Fei Granules (SHJFG)
KW  - lipid
KW  - adiponectin
KW  - resistin
KW  - leptin
Y1  - 2012
SN  - 1433-6510
VL  - 58
IS  - 1-2
SP  - 81
EP  - 87
PB  - Clin Lab Publ., Verl. Klinisches Labor
CY  - Heidelberg
ER  -