TY  - JOUR
A1  - Bäurle, Isabel
T1  - Can't remember to forget you
BT  - Chromatin-based priming of somatic stress responses
JF  - Seminars in cell & developmental biology
N2  - In nature plants are exposed to frequent changes in their abiotic and biotic environment. While some environmental cues are used to gauge the environment and align growth and development, others are beyond the regularly encountered spectrum of a species and trigger stress responses. Such stressful conditions provide a potential threat to survival and integrity. Plants adapt to extreme environmental conditions through physiological adaptations that are usually transient and are maintained until stressful environments subside. It is increasingly appreciated that in some cases environmental cues activate a stress memory that persists for some time after the extreme condition has subsided. Recent research has shown that this stress-induced environmental memory is mediated by epigenetic and chromatin-based mechanisms and both histone methylation and nucleosome occupancy are associated with it.
KW  - Priming
KW  - Transcriptional memory
KW  - Chromatin
KW  - H3K4 methylation
KW  - Nucleosome occupancy
Y1  - 2017
U6  - https://doi.org/10.1016/j.semcdb.2017.09.032
SN  - 1084-9521
VL  - 83
SP  - 133
EP  - 139
PB  - Elsevier
CY  - London
ER  - 
TY  - JOUR
A1  - Liu, Junzhong
A1  - Feng, Lili
A1  - Gu, Xueting
A1  - Deng, Xian
A1  - Qiu, Qi
A1  - Li, Qun
A1  - Zhang, Yingying
A1  - Wang, Muyang
A1  - Deng, Yiwen
A1  - Wang, Ertao
A1  - He, Yuke
A1  - Bäurle, Isabel
A1  - Li, Jianming
A1  - Cao, Xiaofeng
A1  - He, Zuhua
T1  - An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis
JF  - Cell research
N2  - Global warming has profound effects on plant growth and fitness. Plants have evolved sophisticated epigenetic machinery to respond quickly to heat, and exhibit transgenerational memory of the heat-induced release of post-transcriptional gene silencing (PTGS). However, how thermomemory is transmitted to progeny and the physiological relevance are elusive. Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2) directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6 (REF6), which in turn derepresses HSFA2. REF6 and HSFA2 establish a heritable feedback loop, and activate an E3 ubiquitin ligase, SUPPRESSOR OF GENE SILENCING 3 (SGS3)-INTERACTING PROTEIN 1 (SGIP1). SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA (tasiRNA). The REF6-HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5 (HTT5), which drives early flowering but attenuates immunity. Thus, heat induces transmitted phenotypes via a coordinated epigenetic network involving histone demethylases, transcription factors, and tasiRNAs, ensuring reproductive success and transgenerational stress adaptation.
KW  - Chromatin
KW  - Epigenetic memory
KW  - Epigenetics
KW  - Innate immunity
KW  - Plant signalling
Y1  - 2019
U6  - https://doi.org/10.1038/s41422-019-0145-8
SN  - 1001-0602
SN  - 1748-7838
VL  - 29
IS  - 5
SP  - 379
EP  - 390
PB  - Nature Publ. Group
CY  - London
ER  -