TY  - JOUR
A1  - Shahid, Muhammad
A1  - Manchi, G.
A1  - Slunsky, Pavel
A1  - Naseer, O.
A1  - Fatima, A.
A1  - Leo, B.
A1  - Raila, Jens
T1  - A systemic review of existing serological possibilities to diagnose canine osteoarthritis with a particular focus on extracellular matrix proteoglycans and protein
JF  - Polish journal of veterinary sciences : PJVS : the journal of Committee of Veterinary Sciences of Polish Academy of Sciences and University of Warmia and Mazury in Olsztyn
N2  - Extra-cellular matrix (ECM) components are important and their stabilization is significant in maintaining normal healthy joint environment. In osteoarthritis (OA), ECM components are altered and indicate disease progression. The joint ECM is composed of proteoglycans (aggrecan, perlecan,inter α-trypsin inhibitor), glycoproteins (fibronectin, lubricin, COMP) and collagen types (most abundantly collagen type II) which represent structural and functional transformation during disease advancement. ECM investigation revealed significant biomarkers of OA that could be used as a diagnostic and therapeutic tool in different canine orthopedic diseases. This review deliberates our current findings of how the components of ECM change at the molecular level during disease progression in canine OA.
KW  - extra-cellular matrix
KW  - canine osteoarthritis
KW  - biomarker
KW  - synovial fluid
KW  - proteomix analysis
Y1  - 2017
U6  - https://doi.org/10.1515/pjvs-2017-0024
SN  - 1505-1773
SN  - 2300-2557
VL  - 20
IS  - 1
SP  - 189
EP  - 201
PB  - De Gruyter
CY  - Berlin
ER  -