TY - JOUR A1 - Zakharova, Anna A1 - Kurths, Jürgen A1 - Vadivasova, Tatyana A1 - Koseska, Aneta T1 - Analysing dynamical behavior of cellular networks via stochastic bifurcations JF - PLoS one N2 - The dynamical structure of genetic networks determines the occurrence of various biological mechanisms, such as cellular differentiation. However, the question of how cellular diversity evolves in relation to the inherent stochasticity and intercellular communication remains still to be understood. Here, we define a concept of stochastic bifurcations suitable to investigate the dynamical structure of genetic networks, and show that under stochastic influence, the expression of given proteins of interest is defined via the probability distribution of the phase variable, representing one of the genes constituting the system. Moreover, we show that under changing stochastic conditions, the probabilities of expressing certain concentration values are different, leading to different functionality of the cells, and thus to differentiation of the cells in the various types. Y1 - 2011 U6 - https://doi.org/10.1371/journal.pone.0019696 SN - 1932-6203 VL - 6 IS - 5 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Koseska, Aneta A1 - Volkov, Evgenii A1 - Kurths, Jürgen T1 - Synthetic multicellular oscillatory systems controlling protein dynamics with genetic circuits JF - Physica scripta : an international journal for experimental and theoretical physics N2 - Synthetic biology is a relatively new research discipline that combines standard biology approaches with the constructive nature of engineering. Thus, recent efforts in the field of synthetic biology have given a perspective to consider cells as 'programmable matter'. Here, we address the possibility of using synthetic circuits to control protein dynamics. In particular, we show how intercellular communication and stochasticity can be used to manipulate the dynamical behavior of a population of coupled synthetic units and, in this manner, finely tune the expression of specific proteins of interest, e.g. in large bioreactors. Y1 - 2011 U6 - https://doi.org/10.1088/0031-8949/84/04/045007 SN - 0031-8949 VL - 84 IS - 4 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Huang, Tingwen A1 - Chen, Guanrong A1 - Kurths, Jürgen T1 - Synchronization of chaotic of chaotic systems with time-varying coupöing delays JF - Discrete and continuous dynamical systems : a journal bridging mathematics and sciences ; Series B, Mathematical modelling, analysis and computations N2 - In this paper, we study the complete synchronization of a class of time-varying delayed coupled chaotic systems using feedback control. In terms of Linear Matrix Inequalities, a sufficient condition is obtained through using a Lyapunov-Krasovskii functional and differential equation in equalities. The conditions can be easily verified and implemented. We present two simulation examples to illustrate the effectiveness of the proposed method. KW - Synchronization KW - Chaotic System KW - Time-varying Delay Y1 - 2011 U6 - https://doi.org/10.3934/dcdsb.2011.16.1071 SN - 1531-3492 VL - 16 IS - 4 SP - 1071 EP - 1082 PB - American Institute of Mathematical Sciences CY - Springfield ER - TY - JOUR A1 - Donges, Jonathan Friedemann A1 - Donner, Reik Volker A1 - Trauth, Martin H. A1 - Marwan, Norbert A1 - Schellnhuber, Hans Joachim A1 - Kurths, Jürgen T1 - Nonlinear detection of paleoclimate-variability transitions possibly related to human evolution JF - Proceedings of the National Academy of Sciences of the United States of America N2 - Potential paleoclimatic driving mechanisms acting on human evolution present an open problem of cross-disciplinary scientific interest. The analysis of paleoclimate archives encoding the environmental variability in East Africa during the past 5 Ma has triggered an ongoing debate about possible candidate processes and evolutionary mechanisms. In this work, we apply a nonlinear statistical technique, recurrence network analysis, to three distinct marine records of terrigenous dust flux. Our method enables us to identify three epochs with transitions between qualitatively different types of environmental variability in North and East Africa during the (i) Middle Pliocene (3.35-3.15 Ma B. P.), (ii) Early Pleistocene (2.25-1.6 Ma B. P.), and (iii) Middle Pleistocene (1.1-0.7 Ma B. P.). A deeper examination of these transition periods reveals potential climatic drivers, including (i) large-scale changes in ocean currents due to a spatial shift of the Indonesian throughflow in combination with an intensification of Northern Hemisphere glaciation, (ii) a global reorganization of the atmospheric Walker circulation induced in the tropical Pacific and Indian Ocean, and (iii) shifts in the dominating temporal variability pattern of glacial activity during the Middle Pleistocene, respectively. A reexamination of the available fossil record demonstrates statistically significant coincidences between the detected transition periods and major steps in hominin evolution. This result suggests that the observed shifts between more regular and more erratic environmental variability may have acted as a trigger for rapid change in the development of humankind in Africa. KW - African climate KW - Plio-Pleistocene KW - climate-driven evolution KW - dynamical transitions KW - nonlinear time series analysis Y1 - 2011 U6 - https://doi.org/10.1073/pnas.1117052108 SN - 0027-8424 VL - 108 IS - 51 SP - 20422 EP - 20427 PB - National Acad. of Sciences CY - Washington ER -