TY - JOUR A1 - Hennig, Timo A1 - Schramm, Satyam Antonio A1 - Linderkamp, Friedrich T1 - Cross-informant disagreement on behavioral symptoms in adolescent attention-deficit/hyperactivity disorder and its impact on treatment effects JF - European Journal of Psychological Assessment N2 - In assessing adolescent behavior difficulties, parents, teachers, and the adolescents themselves are key informants. However, substantial disagreement has been found between informants. Specifically, children with attention-deficit/hyperactivity disorder (ADHD) tend to overestimate their competencies, also known as "positive (illusionary) bias." This study compared parent, teacher, and adolescent ratings of ADHD and other behavioral symptoms in a sample of 114 adolescents with ADHD. Further, the effect of cross-informant disagreement (CID) on treatment outcomes was investigated in a subsample of 54 adolescents who had undergone a training and coaching intervention. Overall, there was moderate agreement among informants. Parent and adolescent ratings were more strongly correlated with each other than with teacher ratings. The strongest discrepancy was found between teacher and adolescent ratings on prosocial behavior. This discrepancy explained 12% of the variance in parent-rated ADHD symptom severity after the intervention. The treatment was less effective in participants with high teacher-adolescent disagreement on prosocial behavior (d = 0.41) than with low disagreement (d = 0.98). These findings suggest that professionals working with adolescents with ADHD should consider multiple sources of information before initiating treatment and pay attention to cross-informant disagreements because these may indicate a risk of diminished treatment effects. KW - informant discrepancies KW - inter-rater reliability KW - positive illusionary bias KW - response to treatment KW - ADHD Y1 - 2017 U6 - https://doi.org/10.1027/1015-5759/a000446 SN - 1015-5759 SN - 2151-2426 VL - 34 IS - 2 SP - 79 EP - 86 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Millenet, Sabina A1 - Laucht, Manfred A1 - Hohm, Erika A1 - Jennen-Steinmetz, Christine A1 - Hohmann, Sarah A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Banaschewski, Tobias A1 - Brandeis, Daniel A1 - Zohsel, Katrin T1 - Sex-specific trajectories of ADHD symptoms from adolescence to young adulthood JF - European child and adolescent psychiatry : offical journal of the European Society for Child and Adolescent Psychiatry N2 - Reports of current ADHD symptoms in adults with a childhood diagnosis of ADHD are often discrepant: While one subgroup reports a particularly high level of current ADHD symptoms, another reports—in contrast—a very low level. The reasons for this difference remain unclear. Although sex might play a moderating role, it has not yet been examined in this regard. In an epidemiological cohort study from birth to young adulthood, childhood ADHD diagnoses were assessed at the ages of 4.5, 8, and 11 years based on parent ratings. Sex-specific development of ADHD symptoms was analyzed from the age of 15 to 25 years via self-reported ADHD symptoms in participants with (n = 47) and without childhood ADHD (n = 289) using a random coefficient regression model. The congruence between parent reports and adolescents’ self-ratings was examined, and the role of childhood ADHD diagnosis, childhood OCC/CD, and childhood internalizing disorder as possible sex-specific predictors of self-reported ADHD symptoms at age 25 years was investigated. With regard to self-reported ADHD symptoms, females with a childhood ADHD diagnosis reported significantly more ADHD symptoms compared to females without childhood ADHD and males with and without ADHD throughout adolescence and young adulthood. In contrast, males with childhood ADHD did not differ from control males either at age 15 or at age 25 years. Only in females did a childhood diagnosis of an externalizing disorder (ADHD and CD/ODD) predict self-reported ADHD symptoms by age 25 years. Our findings suggest that self-reports of young adults with a childhood diagnosis of ADHD are influenced by sex. Specifically, females with childhood ADHD report increased levels of ADHD symptoms upon reaching adulthood. To correctly evaluate symptoms and impairment in this subgroup, other, more objective, sources of information may be advisable, such as neurophysiological measures. KW - ADHD KW - Sex KW - Self-report KW - Longitudinal study Y1 - 2018 U6 - https://doi.org/10.1007/s00787-018-1129-9 SN - 1018-8827 SN - 1435-165X VL - 27 IS - 8 SP - 1067 EP - 1075 PB - Springer CY - New York ER - TY - JOUR A1 - Holz, Nathalie E. A1 - Boecker-Schlier, Regina A1 - Jennen-Steinmetz, Christine A1 - Hohm, Erika A1 - Buchmann, Arlette F. A1 - Blomeyer, Dorothea A1 - Baumeister, Sarah A1 - Plichta, Michael M. A1 - Esser, Günter A1 - Schmidt, Martin A1 - Meyer-Lindenberg, Andreas A1 - Banaschewski, Tobias A1 - Brandeis, Daniel A1 - Laucht, Manfred T1 - Early maternal care may counteract familial liability for psychopathology in the reward circuitry JF - Social Cognitive and Affective Neuroscience N2 - Reward processing is altered in various psychopathologies and has been shown to be susceptible to genetic and environmental influences. Here, we examined whether maternal care may buffer familial risk for psychiatric disorders in terms of reward processing. Functional magnetic resonance imaging during a monetary incentive delay task was acquired in participants of an epidemiological cohort study followed since birth (N = 172, 25 years). Early maternal stimulation was assessed during a standardized nursing/playing setting at the age of 3 months. Parental psychiatric disorders (familial risk) during childhood and the participants’ previous psychopathology were assessed by diagnostic interview. With high familial risk, higher maternal stimulation was related to increasing activation in the caudate head, the supplementary motor area, the cingulum and the middle frontal gyrus during reward anticipation, with the opposite pattern found in individuals with no familial risk. In contrast, higher maternal stimulation was associated with decreasing caudate head activity during reward delivery and reduced levels of attention deficit hyperactivity disorder (ADHD) in the high-risk group. Decreased caudate head activity during reward anticipation and increased activity during delivery were linked to ADHD. These findings provide evidence of a long-term association of early maternal stimulation on both adult neurobiological systems of reward underlying externalizing behavior and ADHD during development. KW - maternal care KW - ADHD KW - ventral striatum KW - fMRI KW - resilience KW - aggression Y1 - 2018 U6 - https://doi.org/10.1093/scan/nsy087 SN - 1749-5016 SN - 1749-5024 VL - 13 IS - 11 SP - 1191 EP - 1201 PB - Oxford Univ. Press CY - Oxford ER - TY - GEN A1 - Hennig, Timo A1 - Schramm, Satyam Antonio A1 - Linderkamp, Friedrich T1 - Cross-informant disagreement on behavioral symptoms in adolescent attention-deficit/hyperactivity disorder and its impact on treatment effects T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - In assessing adolescent behavior difficulties, parents, teachers, and the adolescents themselves are key informants. However, substantial disagreement has been found between informants. Specifically, children with attention-deficit/hyperactivity disorder (ADHD) tend to overestimate their competencies, also known as “positive (illusionary) bias.” This study compared parent, teacher, and adolescent ratings of ADHD and other behavioral symptoms in a sample of 114 adolescents with ADHD. Further, the effect of cross-informant disagreement (CID) on treatment outcomes was investigated in a subsample of 54 adolescents who had undergone a training and coaching intervention. Overall, there was moderate agreement among informants. Parent and adolescent ratings were more strongly correlated with each other than with teacher ratings. The strongest discrepancy was found between teacher and adolescent ratings on prosocial behavior. This discrepancy explained 12% of the variance in parent-rated ADHD symptom severity after the intervention. The treatment was less effective in participants with high teacher-adolescent disagreement on prosocial behavior (d = 0.41) than with low disagreement (d = 0.98). These findings suggest that professionals working with adolescents with ADHD should consider multiple sources of information before initiating treatment and pay attention to cross-informant disagreements because these may indicate a risk of diminished treatment effects. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 631 KW - informant discrepancies KW - inter-rater reliability KW - positive illusionary bias KW - response to treatment KW - ADHD Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-441329 SN - 1866-8364 IS - 631 SP - 79 EP - 86 ER - TY - JOUR A1 - Klein, Angela Ines A1 - Kruegel, Andre A1 - Risse, Sarah A1 - Esser, Günter A1 - Engbert, Ralf A1 - Pereira, Vera Wannmacher T1 - The processing of pronominal anaphora by children that have attention deficit hyperactivity disorder or dyslexia: a study through the analysis of eye movements JF - Letras de hoje N2 - The aim of this work was to verify the processing of pronominal anaphora by children that have attention deficit hyperactivity disorder or dyslexia. The sample studied consisted of 75 children that speak German, which read two texts of 80 words containing pronominal anaphora. The eye movements of all participants were recorded and, to make sure they were reading with attention, two activities that tested reading comprehension were proposed. Through the analysis of eye movements, specifically the fixations, the data indicate that children with disorders have difficulty to process the pronominal anaphora, especially dyslexic children. KW - ADHD KW - Dyslexia KW - Reading comprehension KW - Eye movements KW - Pronominal anaphora Y1 - 2015 SN - 0101-3335 SN - 1984-7726 VL - 50 IS - 1 SP - 40 EP - 48 PB - PUCRS CY - Porto Alegre ER - TY - JOUR A1 - Bondü, Rebecca A1 - Esser, Günter T1 - Justice and rejection sensitivity in children and adolescents with ADHD symptoms JF - European child and adolescent psychiatry : offical journal of the European Society for Child and Adolescent Psychiatry N2 - Justice sensitivity captures individual differences in the frequency with which injustice is perceived and the intensity of emotional, cognitive, and behavioral reactions to it. Persons with ADHD have been reported to show high justice sensitivity, and a recent study provided evidence for this notion in an adult sample. In 1,235 German 10- to 19-year olds, we measured ADHD symptoms, justice sensitivity from the victim, observer, and perpetrator perspective, the frequency of perceptions of injustice, anxious and angry rejection sensitivity, depressive symptoms, conduct problems, and self-esteem. Participants with ADHD symptoms reported significantly higher victim justice sensitivity, more perceptions of injustice, and higher anxious and angry rejection sensitivity, but significantly lower perpetrator justice sensitivity than controls. In latent path analyses, justice sensitivity as well as rejection sensitivity partially mediated the link between ADHD symptoms and comorbid problems when considered simultaneously. Thus, both justice sensitivity and rejection sensitivity may contribute to explaining the emergence and maintenance of problems typically associated with ADHD symptoms, and should therefore be considered in ADHD therapy. KW - ADHD KW - Justice sensitivity KW - Rejection sensitivity KW - Conduct problems KW - Depressive symptoms Y1 - 2015 U6 - https://doi.org/10.1007/s00787-014-0560-9 SN - 1018-8827 SN - 1435-165X VL - 24 IS - 2 SP - 185 EP - 198 PB - Springer CY - New York ER - TY - JOUR A1 - Holtmann, Martin A1 - Buchmann, Arlette F. A1 - Esser, Günter A1 - Schmidt, Martin H. A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - The child behavior checklist-dysregulation profile predicts substance use, suicidality, and functional impairment a longitudinal analysis JF - The journal of child psychology and psychiatry N2 - Background: Recent studies have identified a Child Behavior Checklist profile that characterizes children with severe affective and behavioral dysregulation (CBCL-dysregulation profile, CBCL-DP). In two recent longitudinal studies the CBCL-DP in childhood was associated with heightened rates of comorbid psychiatric disorders, among them bipolar disorder, an increased risk for suicidality, and marked psychosocial impairment at young-adult follow-up. This is the first study outside the US that examines the longitudinal course of the CBCL-DP. Methods: We studied the diagnostic and functional trajectories and the predictive utility of the CBCL-DP in the Mannheim Study of Children at Risk, an epidemiological cohort study on the outcome of early risk factors from birth into adulthood. A total of 325 young adults (151 males, 174 females) participated in the 19-year assessment. Results: Young adults with a higher CBCL-DP score in childhood were at increased risk for substance use disorders, suicidality and poorer overall functioning at age 19, even after adjustment for parental education, family income, impairment and psychiatric disorders at baseline. Childhood dysregulation was not related to bipolar disorder in young adulthood. The CBCL-DP was neither a precursor of a specific pattern of comorbidity nor of comorbidity in general. Conclusions: Children with high CBCL-DP values are at risk for later severe, psychiatric symptomatology. The different developmental trajectories suggest that the CBCL-DP is not simply an early manifestation of a single disease process but might rather be an early developmental risk marker of a persisting deficit of self-regulation of affect and behavior. KW - Dysregulation KW - childhood KW - comorbidity KW - longitudinal KW - irritability KW - depression KW - ADHD KW - substance use KW - suicidality KW - CBCL KW - bipolar Y1 - 2011 U6 - https://doi.org/10.1111/j.1469-7610.2010.02309.x SN - 0021-9630 VL - 52 IS - 2 SP - 139 EP - 147 PB - Wiley-Blackwell CY - Malden ER - TY - JOUR A1 - Bakhshayesh, Ali Reza A1 - Hänsch, Sylvana A1 - Wyschkon, Anne A1 - Rezai, Mohammad Javad A1 - Esser, Günter T1 - Neurofeedback in ADHD a single-blind randomized controlled trial JF - European child and adolescent psychiatry : offical journal of the European Society for Child and Adolescent Psychiatry N2 - Neurofeedback treatment has been demonstrated to reduce inattention, impulsivity and hyperactivity in children with attention deficit/hyperactivity disorder (ADHD). However, previous studies did not adequately control confounding variables or did not employ a randomized reinforcer-controlled design. This study addresses those methodological shortcomings by comparing the effects of the following two matched biofeedback training variants on the primary symptoms of ADHD: EEG neurofeedback (NF) aiming at theta/beta ratio reduction and EMG biofeedback (BF) aiming at forehead muscle relaxation. Thirty-five children with ADHD (26 boys, 9 girls; 6-14 years old) were randomly assigned to either the therapy group (NF; n = 18) or the control group (BF; n = 17). Treatment for both groups consisted of 30 sessions. Pre- and post-treatment assessment consisted of psychophysiological measures, behavioural rating scales completed by parents and teachers, as well as psychometric measures. Training effectively reduced theta/beta ratios and EMG levels in the NF and BF groups, respectively. Parents reported significant reductions in primary ADHD symptoms, and inattention improvements in the NF group were higher compared to the control intervention (BF, d(corr) = -.94). NF training also improved attention and reaction times on the psychometric measures. The results indicate that NF effectively reduced inattention symptoms on parent rating scales and reaction time in neuropsychological tests. However, regarding hyperactivity and impulsivity symptoms, the results imply that non-specific factors, such as behavioural contingencies, self-efficacy, structured learning environment and feed-forward processes, may also contribute to the positive behavioural effects induced by neurofeedback training. KW - Biofeedback KW - Neurofeedback KW - EMG biofeedback KW - ADHD KW - Single-blind Y1 - 2011 U6 - https://doi.org/10.1007/s00787-011-0208-y SN - 1018-8827 VL - 20 IS - 9 SP - 481 EP - 491 PB - Springer CY - New York ER - TY - THES A1 - Bakhshayesh, Ali Reza T1 - Die Wirksamkeit von Neurofeedback im Vergleich zum EMG-Biofeedback bei der Behandlung von ADHS-Kindern T1 - Effectiveness of neurofeedback in comparison with EMG-biofeedback in the treatment of ADHD-children N2 - Seit vier Jahrzehnten werden verschiedene Neurofeedbackmethoden bei der Behandlung unterschiedlicher Störungen, unter anderem bei AD/HS-Kindern, eingesetzt. Die Grundlage der Anwendung von Neurofeedback bei dieser Störung besteht darin, dass die Kinder Auffälligkeiten in ihrem EEG zeigen. Dort treten im Vergleich zu unauffälligen Kindern vermehrt Theta-Gehirnwellen und weniger Beta-Gehirnwellen auf. Mittels Neurofeedback wird versucht, die Gehirnfunktionen zu korrigieren. Zahlreiche Einzellfallstudien bestätigen die Wirksamkeit dieser Therapiemethode bei der AD/HS-Behandlung. Bisher wurde jedoch keine Studie veröffentlicht, in der die Wirksamkeit von Neurofeedback mit einer Placebogruppe verglichen wurde. Ziel der vorliegenden Studie war es, die Wirksamkeit eines Theta/Beta-Neurofeedbacks (NF) bei der Behandlung von AD/HS-Kindern zu überprüfen und mit einem EMG-Biofeedback (BF) als Placebobedingung zu vergleichen. Es wurden 35 ADHS-Kinder (6 -14 Jahre; 26 Jungen und 9 Mädchen) untersucht. Nach Standarddiagnostik und Vergabe der AD/HS-Diagnose durch einen unabhängigen Psychotherapeuten wurden die Kinder per Zufall zwei Gruppen (NF: n = 18 bzw. BF: n = 17) zugeteilt. Alle Kinder beider Gruppen erhielten ein 30 Sitzungen umfassendes Training mittels Theta/Beta-Neurofeedback bzw. EMG-Biofeedback. Unmittelbar vor und nach dem Training wurden Intelligenz- bzw. Aufmerksamkeitsleistungen untersucht und Einschätzungen des Verhaltens von Eltern und Lehrern erhoben. Im Anschluss an das Training erfolgte eine erneute diagnostische Einschätzung durch einen unabhängigen Psychotherapeuten. Die EEG-Daten in der NF-Gruppe zeigen eine Reduktion der Theta/Beta-Quotienten im Laufe der NF-Sitzungen. Die EMG-Daten zeigen für die EMG-Biofeedback-Bedingung gleichfalls eine Reduktion der EMG-Amplitude. Die Ergebnisse der zweifaktoriellen Varianzanalysen mit Messwiederholung auf einem Faktor zeigen für die angewendeten diagnostischen Verfahren die erwarteten signifikanten Interaktionen zwischen Messzeitpunkt und Gruppe. Die Ergebnisse des t-Tests zeigen signifikante Verbesserungen in der Aufmerksamkeitsleistung, dem Intelligenzniveau und im Verhalten der Kinder aus der NF-Gruppe im Vergleich zu den Resultaten des Prä-Tests. Die EMG-Biofeedbackgruppe zeigt mit Ausnahme einer Erhöhung des Arbeitstempos in den Paper-Pencil-Aufmerksamkeitstests (die im CPT nicht repliziert werden konnte) keine signifikanten Verbesserungen relativ zum Prä-Test. Nach dem Training erhielten 55,6 % (n = 10) der AD/HS-Kinder aus der Neurofeedbackgruppe und 23,5 % (n = 4) der Kinder aus der EMG-Biofeedbackgruppe keine AD/HS-Diagnose nach den Kriterien der ICD-10. Der Chi-Quadrat-Test zeigt jedoch lediglich einen tendenziell bedeutsamen Unterschied (p = .086). Insgesamt bestätigen die Ergebnisse die Wirksamkeit des Neurofeedbacks bei der Behandlung von ADHS-Kindern im Vergleich mit einer Placebogruppe. Weitere Studien in diesem Bereich sind notwendig, um die Wirksamkeit des Neurofeedbacktrainings im Vergleich zu einer Placebomethode bei der ADHS-Behandlung zu untersuchen. N2 - Neurofeedback (NF) has been introduced four decades ago as an alternative treatment for different disorders, one of these being Attention Deficit/Hyperactivity Disorder (AD/HD). As compared to a control group (non ADHD children), children diagnosed with ADHD show an increased frequency of Theta waves and a decreased frequency of Beta waves in their EEGs. A treatment consisting of NF-training attempts to correct these anomalies. There are numerous single case studies in this area but only a few controlled studies. Furthermore, there are no studies comparing the effect of NF in the treatment of ADHD with a placebo group. This study sets out to evaluate the effects of 30 (Theta/Beta) NF training sessions on ADHD symptoms and compare those with the effects of the placebo EMG-biofeedback (BF) training group. The subjects, consisting of 35 children both male (n = 26) and female (n = 9) between the ages of 6 and 14 diagnosed with ADHD by independent psychotherapists, were randomly assigned to either the treatment group (NF; n = 18) or the placebo group (BF; n = 17). In addition to the Theta/Beta quotient (in NF group) and EMG-Amplitude (in BF group) as seen during the sessions, pre and post measures of the subjects´ intelligence (Raven Test), paper-pencil attention test scores (bp/d2), Continuous Performance Task (CPT) as well as symptom ratings (MEF and FBB-HKS) from both teachers and parents were obtained. Finally, subjects were re-evaluated after treatment by independent psychotherapists. The results showed a significant decrease in the Theta/Beta quotient after the NF training and a significant decrease in the EMG-Amplitude after the BF-training. The results of an ANOVA with repeated measures showed significant differences between the treatment group (NF training) and the placebo (BF training) group in attention tests and symptom rating scores after treatment. Compared to the pre-test scores, subjects in the NF group showed significant improvements in attention scores, intelligence scores, and behaviour after the NF training sessions. The BF placebo group showed no significant improvements in any of the outcome variables except on the speed scale of the paper-pencil attention tests (this was incompatible with the results of CPT). Finally, 55.6% (n = 10) of the children in the NF training group were not diagnosed with ADHD (using ICD-10 criteria) at the time of the second evaluation. In the BF group, 23.5% (n = 4) were not diagnosed with ADHD by independent psychotherapists at the end of the BF training. The results indicate that NF training in comparing with a placebo method is an effective treatment method in the treatment of ADHD children. Further studies are necessary in comparing the effectiveness of NF training with more neutral placebo interventions in the treatment of children with ADHD. KW - Neurofeedback KW - EMG-Biofeedback KW - ADHS KW - Placebo KW - neurofeedback KW - EMG-biofeedback KW - ADHD KW - placebo Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-15358 ER -