TY  - JOUR
A1  - Li, Zhengdong
A1  - Xu, Xun
A1  - Wang, Weiwei
A1  - Kratz, Karl
A1  - Sun, Xianlei
A1  - Zou, Jie
A1  - Deng, Zijun
A1  - Jung, Friedrich Wilhelm
A1  - Gossen, Manfred
A1  - Ma, Nan
A1  - Lendlein, Andreas
T1  - Modulation of the mesenchymal stem cell migration capacity via preconditioning with topographic microstructure
JF  - Clinical hemorheology and microcirculation : blood flow and vessels
N2  - Controlling mesenchymal stem cells (MSCs) behavior is necessary to fully exploit their therapeutic potential. Various approaches are employed to effectively influence the migration capacity of MSCs. Here, topographic microstructures with different microscale roughness were created on polystyrene (PS) culture vessel surfaces as a feasible physical preconditioning strategy to modulate MSC migration. By analyzing trajectories of cells migrating after reseeding, we demonstrated that the mobilization velocity of human adipose derived mesenchymal stem cells (hADSCs) could be promoted by and persisted after brief preconditioning with the appropriate microtopography. Moreover, the elevated activation levels of focal adhesion kinase (FAK) and mitogen-activated protein kinase (MAPK) in hADSCs were also observed during and after the preconditioning process. These findings underline the potential enhancement of in vivo therapeutic efficacy in regenerative medicine via transplantation of topographic microstructure preconditioned stem cells.
KW  - Mesenchymal stem cells
KW  - precondition
KW  - microstructure
KW  - migration
KW  - FAK-MAPK
Y1  - 2017
U6  - https://doi.org/10.3233/CH-179208
SN  - 1386-0291
SN  - 1875-8622
VL  - 67
SP  - 267
EP  - 278
PB  - IOS Press
CY  - Amsterdam
ER  -