TY  - JOUR
A1  - Braune, Steffen
A1  - Latour, Robert A.
A1  - Reinthaler, Markus
A1  - Landmesser, Ulf
A1  - Lendlein, Andreas
A1  - Jung, Friedrich
T1  - In Vitro Thrombogenicity Testing of Biomaterials
JF  - Advanced healthcare materials
N2  - The short- and long-term thrombogenicity of implant materials is still unpredictable, which is a significant challenge for the treatment of cardiovascular diseases. A knowledge-based approach for implementing biofunctions in materials requires a detailed understanding of the medical device in the biological system. In particular, the interplay between material and blood components/cells as well as standardized and commonly acknowledged in vitro test methods allowing a reproducible categorization of the material thrombogenicity requires further attention. Here, the status of in vitro thrombogenicity testing methods for biomaterials is reviewed, particularly taking in view the preparation of test materials and references, the selection and characterization of donors and blood samples, the prerequisites for reproducible approaches and applied test systems. Recent joint approaches in finding common standards for a reproducible testing are summarized and perspectives for a more disease oriented in vitro thrombogenicity testing are discussed.
KW  - biomaterials
KW  - blood tests
KW  - implants
KW  - in vitro
KW  - thrombogenicity
Y1  - 2019
U6  - https://doi.org/10.1002/adhm.201900527
SN  - 2192-2640
SN  - 2192-2659
VL  - 8
IS  - 21
PB  - Wiley
CY  - Hoboken
ER  -