TY - JOUR A1 - Johann, Kornelia A1 - Kleinert, Maximilian A1 - Klaus, Susanne T1 - The role of GDF15 as a myomitokine JF - Cells N2 - Growth differentiation factor 15 (GDF15) is a cytokine best known for affecting systemic energy metabolism through its anorectic action. GDF15 expression and secretion from various organs and tissues is induced in different physiological and pathophysiological states, often linked to mitochondrial stress, leading to highly variable circulating GDF15 levels. In skeletal muscle and the heart, the basal expression of GDF15 is very low compared to other organs, but GDF15 expression and secretion can be induced in various stress conditions, such as intense exercise and acute myocardial infarction, respectively. GDF15 is thus considered as a myokine and cardiokine. GFRAL, the exclusive receptor for GDF15, is expressed in hindbrain neurons and activation of the GDF15-GFRAL pathway is linked to an increased sympathetic outflow and possibly an activation of the hypothalamic-pituitary-adrenal (HPA) stress axis. There is also evidence for peripheral, direct effects of GDF15 on adipose tissue lipolysis and possible autocrine cardiac effects. Metabolic and behavioral outcomes of GDF15 signaling can be beneficial or detrimental, likely depending on the magnitude and duration of the GDF15 signal. This is especially apparent for GDF15 production in muscle, which can be induced both by exercise and by muscle disease states such as sarcopenia and mitochondrial myopathy. KW - anorexia KW - appetite regulation KW - cardiokine KW - cytokine KW - exercise KW - mitochondria KW - muscle KW - myokine KW - myopathy KW - sarcopenia Y1 - 2021 U6 - https://doi.org/10.3390/cells10112990 SN - 2073-4409 VL - 10 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Lesinski, Melanie A1 - Prieske, Olaf A1 - Chaabene, Helmi A1 - Granacher, Urs T1 - Seasonal effects of strength endurance vs. power training in young female soccer athletes JF - Journal of strength and conditioning research : the research journal of the NSCA N2 - Lesinski, M, Prieske, O, Chaabene, H, and Granacher, U. Seasonal effects of strength endurance vs. power training in young female soccer athletes. J Strength Cond Res 35(12S): S90-S96, 2021-This study examined the seasonal effects of strength endurance training (SET) vs. power training (PT) on physical fitness and body composition in young female soccer players. Thirty-six young female elite soccer players (15 +/- 1 years; maturity offset +3 +/- 1 years) were allocated to progressive SET (n = 19) or PT (n = 17). Over the course of one soccer season, SET performed slow movement velocity, moderate intensity (50-60% of the 1 repetition maximum [1RM]; 20-40 repetitions) strength exercises while PT performed moderate-to-high intensity (50-95% of the 1RM; 3-8 repetitions), high movement velocity strength exercises (2 sessions center dot wk(-1)). Before and after training, tests were performed for the assessment of muscle strength (1RM leg press), jump performance (countermovement jump [CMJ], drop jump [DJ]), muscular endurance (ventral Bourban test), linear speed (10 m, 20 m), change-of-direction (CoD) speed (T-test), dynamic balance (Y-balance test), sport-specific performance (kicking velocity), and body composition (lean body mass and fat mass). An analysis of covariance was used to test for between-group differences at post-test with baseline values as covariate. No significant between-group differences were observed in terms of total training volume over the respective soccer seasons (p = 0.069; d = 0.68). At post-test, SET showed significantly better ventral Bourban and T-test performances (d = 1.28-2.28; p = 0.000-0.001) compared with PT. However, PT resulted in significantly better 1RM leg press, DJ, 10-m, and 20-m sprint performances (d = 0.85-1.44; p = 0.000-0.026). No significant between-group differences were observed at post-test for CMJ, Y-balance test, kicking performance, and body composition (d = 0.20-0.74, p = 0.051-0.594). Our findings are mainly in accordance with the principle of training specificity. Both SET and PT are recommended to be implemented in young female elite soccer players according to the respective training period. KW - strength training KW - elite KW - training specificity KW - soccer players KW - muscle KW - endurance KW - periodization Y1 - 2021 U6 - https://doi.org/10.1519/JSC.0000000000003564 SN - 1064-8011 SN - 1533-4287 VL - 35 IS - Supplement 12 SP - S90 EP - S96 PB - Lippincott Williams & Wilkins CY - Philadelphia ER -