TY - GEN A1 - Parsons, R. D. A1 - Schüssler, F. A1 - Garrigoux, T. A1 - Balzer, A. A1 - Füssling, Matthias A1 - Hoischen, Clemens A1 - Holler, M. A1 - Mitchell, A. A1 - Pühlhofer, G. A1 - Rowell, G. A1 - Wagner, S. A1 - Bissaldi, E. A1 - Tam, P. H. T. T1 - The HESS II GRB Observation Scheme T2 - AIP conference proceedings / American Institute of Physics N2 - Gamma-ray bursts (GRBs) are some of the Universe’s most enigmatic and exotic events. However, at energies above 10 GeV their behaviour remains largely unknown. Although space based telescopes such as the Fermi-LAT have been able to detect GRBs in this energy range, their photon statistics are limited by the small detector size. Such limitations are not present in ground based gamma-ray telescopes such as the H.E.S.S. experiment, which has now entered its second phase with the addition of a large 600 m2 telescope to the centre of the array. Such a large telescope allows H.E.S.S. to access the sub 100-GeV energy range while still maintaining a large effective collection area, helping to potentially probe the short timescale emission of these events. We present a description of the H.E.S.S. GRB observation programme, summarising the performance of the rapid GRB repointing system and the conditions under which GRB observations are initiated. Additionally we will report on the GRB follow-ups made during the 2014-15 observation campaigns. Y1 - 2017 SN - 978-0-7354-1456-3 U6 - https://doi.org/10.1063/1.4968980 SN - 0094-243X SN - 1551-7616 VL - 1792 IS - 1 PB - American Institute of Physics CY - Melville ER - TY - GEN A1 - Angüner, Ekrem Oǧuzhan A1 - Aharonian, Felix A. A1 - Bordas, Pol A1 - Casanova, Sabrina A1 - Hoischen, Clemens A1 - Oya, I. A1 - Ziegler, A. T1 - HESS J1826-130 BT - a very hard gamma-Ray spectrum source in the Galactic Plane T2 - AIP conference proceedings / American Institute of Physics N2 - HESS J1826-130 is an unidentified hard spectrum source discovered by H.E.S.S. along the Galactic plane, the spectral index being Gamma = 1.6 with an exponential cut-off at about 12 TeV. While the source does not have a clear counterpart at longer wavelengths, the very hard spectrum emission at TeV energies implies that electrons or protons accelerated up to several hundreds of TeV are responsible for the emission. In the hadronic case, the VHE emission can be produced by runaway cosmic-rays colliding with the dense molecular clouds spatially coincident with the H.E.S.S. source. Y1 - 2017 SN - 978-0-7354-1456-3 U6 - https://doi.org/10.1063/1.4968928 SN - 0094-243X SN - 1551-7616 VL - 1792 IS - 1 PB - American Institute of Physics CY - Melville ER - TY - GEN A1 - Kleine-Vehn, Jürgen A1 - Sauer, Michael ED - Kleine-Vehn, Jürgen ED - Sauer, Michael T1 - Preface T2 - Plant Hormones: Methods and Protocols Y1 - 2017 SN - 978-1-4939-6469-7 SN - 978-1-4939-6467-3 U6 - https://doi.org/10.1007/978-1-4939-6469-7 SN - 1064-3745 SN - 1940-6029 VL - 1497 SP - V EP - V PB - Springer CY - New York ET - 3 ER - TY - GEN A1 - Kubatova, B. A1 - Kubát, Jiří A1 - Hamann, Wolf-Rainer A1 - Oskinova, Lida T1 - Clumping in Massive Star Winds and its Possible Connection to the B[e] Phenomenon T2 - The B(e) Phenomenon: Forty Years of Studies : proceedings of a conference held at Charles University, Prague, Czech Republic, 27 June-1 July 2016 N2 - It has been observationally established that winds of hot massive stars have highly variable characteristics. The variability evident in the winds is believed to be caused by structures on a broad range of spatial scales. Small-scale structures (clumping) in stellar winds of hot stars are possible consequence of an instability appearing in their radiation hydrodynamics. To understand how clumping may influence calculation of theoretical spectra, different clumping properties and their 3D nature have to be taken into account. Properties of clumping have been examined using our 3D radiative transfer calculations. Effects of clumping for the case of the B[e] phenomenon are discussed. Y1 - 2017 SN - 978-1-58381-900-5 SN - 978-1-58381-901-2 VL - 508 SP - 45 EP - 50 PB - Astronomical Soceity of the Pacific CY - San Fransisco ER - TY - GEN A1 - Kurfürst, P. A1 - Feldmeier, Achim A1 - Krtička, Jiri T1 - Modeling sgB[e] Circumstellar Disks T2 - The B(e) Phenomenon: Forty Years of Studies : proceedings of a conference held at Charles University, Prague, Czech Republic, 27 June-1 July 2016 N2 - During their evolution, massive stars are characterized by a significant loss of mass either via spherically symmetric stellar winds or by aspherical mass-loss mechanisms, namely outflowing equatorial disks. However, the scenario that leads to the formation of a disk or rings of gas and dust around these objects is still under debate. Is it a viscous disk or an ouftlowing disk-forming wind or some other mechanism? It is also unclear how various physical mechanisms that act on the circumstellar environment of the stars affect its shape, density, kinematic, and thermal structure. We assume that the disk-forming mechanism is a viscous transport within an equatorial outflowing disk of a rapidly or even critically rotating star. We study the hydrodynamic and thermal structure of optically thick dense parts of outflowing circumstellar disks that may form around,e.g., Be stars, sgB[e] stars, or Pop m stars. We calculate self-consistent time dependent models of the inner dense region of the disk that is strongly affected either by irradiation from the central star and by contributions of viscous heating effects. We also simulate the dynamic effects of collision between expanding ejecta of supernovae and circumstellar disks that may be form in sgB[e] stars and, e.g., LBVs or Pop in stars. Y1 - 2017 UR - https://www.physics.muni.cz/~petrk/presentation.pdf SN - 978-1-58381-900-5 SN - 978-1-58381-901-2 VL - 508 SP - 17 EP - 22 PB - Astronomical Scoeity of the Pacific CY - San Fransisco ER - TY - GEN A1 - Hocher, Berthold A1 - Yin, Lianghong T1 - Why Current PTH Assays Mislead Clinical Decision Making in Patients with Secondary Hyperparathyroidism T2 - Nephron N2 - Preclinical studies in cell culture systems as well as in whole animal chronic kidney disease (CKD) models showed that parathyroid hormone (PTH), oxidized at the 2 methionine residues (positions 8 and 18), caused a loss of function. This was so far not considered in the development of PTH assays used in current clinical practice. Patients with advanced CKD are subject to oxidative stress, and plasma proteins (including PTH) are targets for oxidants. In patients with CKD, a considerable but variable fraction (about 70 to 90%) of measured PTH appears to be oxidized. Oxidized PTH (oxPTH) does not interact with the PTH receptor resulting in loss of biological activity. Currently used intact PTH (iPTH) assays detect both oxidized and non-oxPTH (n-oxPTH). Clinical studies demonstrated that bioactive, n-oxPTH, but not iPTH nor oxPTH, is associated with mortality in CKD patients. KW - Serum intact-parathyroid hormone level KW - Dialysis patients KW - Mortality Y1 - 2017 U6 - https://doi.org/10.1159/000455289 SN - 1660-8151 SN - 2235-3186 SN - 0028-2766 VL - 136 IS - 2 SP - 137 EP - 142 PB - Karger CY - Basel ER - TY - GEN A1 - Alibabaie, Najmeh A1 - Ghasemzadeh, Mohammad A1 - Meinel, Christoph T1 - A variant of genetic algorithm for non-homogeneous population T2 - International Conference Applied Mathematics, Computational Science and Systems Engineering 2016 N2 - Selection of initial points, the number of clusters and finding proper clusters centers are still the main challenge in clustering processes. In this paper, we suggest genetic algorithm based method which searches several solution spaces simultaneously. The solution spaces are population groups consisting of elements with similar structure. Elements in a group have the same size, while elements in different groups are of different sizes. The proposed algorithm processes the population in groups of chromosomes with one gene, two genes to k genes. These genes hold corresponding information about the cluster centers. In the proposed method, the crossover and mutation operators can accept parents with different sizes; this can lead to versatility in population and information transfer among sub-populations. We implemented the proposed method and evaluated its performance against some random datasets and the Ruspini dataset as well. The experimental results show that the proposed method could effectively determine the appropriate number of clusters and recognize their centers. Overall this research implies that using heterogeneous population in the genetic algorithm can lead to better results. Y1 - 2017 U6 - https://doi.org/10.1051/itmconf/20170902001 SN - 2271-2097 VL - 9 PB - EDP Sciences CY - Les Ulis ER - TY - GEN A1 - Lorenz, Claas A1 - Kiekheben, Sebastian A1 - Schnor, Bettina T1 - FaVe: Modeling IPv6 firewalls for fast formal verification T2 - International Conference on Networked Systems (NetSys) 2017 N2 - As virtualization drives the automation of networking, the validation of security properties becomes more and more challenging eventually ruling out manual inspections. While formal verification in Software Defined Networks is provided by comprehensive tools with high speed reverification capabilities like NetPlumber for instance, the presence of middlebox functionality like firewalls is not considered. Also, they lack the ability to handle dynamic protocol elements like IPv6 extension header chains. In this work, we provide suitable modeling abstractions to enable both - the inclusion of firewalls and dynamic protocol elements. We exemplarily model the Linux ip6tables/netfilter packet filter and also provide abstractions for an application layer gateway. Finally, we present a prototype of our formal verification system FaVe. Y1 - 2017 U6 - https://doi.org/10.1109/NetSys.2017.7903956 PB - IEEE CY - New York ER - TY - GEN A1 - Gawron, Marian A1 - Cheng, Feng A1 - Meinel, Christoph T1 - PVD: Passive Vulnerability Detection T2 - 8th International Conference on Information and Communication Systems (ICICS) N2 - The identification of vulnerabilities relies on detailed information about the target infrastructure. The gathering of the necessary information is a crucial step that requires an intensive scanning or mature expertise and knowledge about the system even though the information was already available in a different context. In this paper we propose a new method to detect vulnerabilities that reuses the existing information and eliminates the necessity of a comprehensive scan of the target system. Since our approach is able to identify vulnerabilities without the additional effort of a scan, we are able to increase the overall performance of the detection. Because of the reuse and the removal of the active testing procedures, our approach could be classified as a passive vulnerability detection. We will explain the approach and illustrate the additional possibility to increase the security awareness of users. Therefore, we applied the approach on an experimental setup and extracted security relevant information from web logs. Y1 - 2017 SN - 978-1-5090-4243-2 U6 - https://doi.org/10.1109/IACS.2017.7921992 SN - 2471-125X SP - 322 EP - 327 PB - IEEE CY - New York ER - TY - GEN A1 - Mühlbauer, Felix A1 - Schröder, Lukas A1 - Skoncej, Patryk A1 - Schölzel, Mario T1 - Handling manufacturing and aging faults with software-based techniques in tiny embedded systems T2 - 18th IEEE Latin American Test Symposium (LATS 2017) N2 - Non-volatile memory area occupies a large portion of the area of a chip in an embedded system. Such memories are prone to manufacturing faults, retention faults, and aging faults. The paper presents a single software based technique that allows for handling all of these fault types in tiny embedded systems without the need for hardware support. This is beneficial for low-cost embedded systems with simple memory architectures. A software infrastructure and a flow are presented that demonstrate how the presented technique is used in general for fault handling right after manufacturing and in-the-field. Moreover, a full implementation is presented for a MSP430 microcontroller, along with a discussion of the performance, overhead, and reliability impacts. Y1 - 2027 SN - 978-1-5386-0415-1 U6 - https://doi.org/10.1109/LATW.2017.7906756 PB - IEEE CY - New York ER - TY - GEN A1 - Mühlbauer, Felix A1 - Schröder, Lukas A1 - Schölzel, Mario T1 - On hardware-based fault-handling in dynamically scheduled processors T2 - 20th International Symposium on Design and Diagnostics of Electronic Circuits & Systems (DDECS) 2017 N2 - This paper describes architectural extensions for a dynamically scheduled processor, so that it can be used in three different operation modes, ranging from high-performance, to high-reliability. With minor hardware-extensions of the control path, the resources of the superscalar data-path can be used either for high-performance execution, fail-safe-operation, or fault-tolerant-operation. This makes the processor-architecture a very good candidate for applications with dynamically changing reliability requirements, e.g. for automotive applications. The paper reports the hardware-overhead for the extensions, and investigates the performance penalties introduced by the fail-safe and fault-tolerant mode. Furthermore, a comprehensive fault simulation was carried out in order to investigate the fault-coverage of the proposed approach. Y1 - 2017 SN - 978-1-5386-0472-4 U6 - https://doi.org/10.1109/DDECS.2017.7934572 SN - 2334-3133 SN - 2473-2117 SP - 201 EP - 206 PB - IEEE CY - New York ER - TY - GEN A1 - Malchow, Martin A1 - Renz, Jan A1 - Bauer, Matthias A1 - Meinel, Christoph T1 - Embedded smart home BT - remote lab grading in a MOOC with over 6000 participants T2 - 11th Annual IEEE International Systems Conference (SysCon) N2 - The popularity of MOOCs has increased considerably in the last years. A typical MOOC course consists of video content, self tests after a video and homework, which is normally in multiple choice format. After solving this homeworks for every week of a MOOC, the final exam certificate can be issued when the student has reached a sufficient score. There are also some attempts to include practical tasks, such as programming, in MOOCs for grading. Nevertheless, until now there is no known possibility to teach embedded system programming in a MOOC course where the programming can be done in a remote lab and where grading of the tasks is additionally possible. This embedded programming includes communication over GPIO pins to control LEDs and measure sensor values. We started a MOOC course called "Embedded Smart Home" as a pilot to prove the concept to teach real hardware programming in a MOOC environment under real life MOOC conditions with over 6000 students. Furthermore, also students with real hardware have the possibility to program on their own real hardware and grade their results in the MOOC course. Finally, we evaluate our approach and analyze the student acceptance of this approach to offer a course on embedded programming. We also analyze the hardware usage and working time of students solving tasks to find out if real hardware programming is an advantage and motivating achievement to support students learning success. Y1 - 2017 SN - 978-1-5090-4623-2 U6 - https://doi.org/10.1109/SYSCON.2017.7934728 SN - 1944-7620 SP - 195 EP - 200 PB - IEEE CY - New York ER - TY - GEN A1 - Angerer, Marie-Luise T1 - Moving Forces T2 - The minnesota review N2 - Throughout a large part of the twentieth century, the body was interpreted as a field of signs, the meaning of which pointed to an unconscious dimension. At the height of the popularity of structuralism, Jacques Lacan deemed the unconscious to be “structured like a language.” Starting in the early 1990s, however, a deep shift occurred in the way the body was interpreted. A new movement cast tremendous doubt on the hegemony of language and instead advocated a performative, pictorial, and affective approach — the so-called material turn — which encompassed all of these. In the words of Karen Barad, this turn inquired as to why meaning, history, and truth are assigned to language only, whereas the movements of materiality are given less prominence: “How did language come to be more trustworthy than matter? Why are language and culture granted their own agency and historicity while matter is figured as passive and immutable?” With this shift toward the material, bodies began to be seen in a different light and their materiality understood as something that follows its own laws and movements, which cannot be understood exclusively in terms of social-cultural codes. Instead, these laws and movements call into question the very dichotomies of nature/culture and body/spirit. KW - mattering KW - wondering KW - contingent encounters KW - affect KW - blind feeling KW - sensation Y1 - 2017 U6 - https://doi.org/10.1215/00265667-3787414 SN - 0026-5667 SN - 2157-4189 VL - 88 SP - 83 EP - 95 PB - Duke Univ. Press CY - Durham ER - TY - GEN A1 - Neubauer, Kai A1 - Wanko, Philipp A1 - Schaub, Torsten H. A1 - Haubelt, Christian T1 - Enhancing symbolic system synthesis through ASPmT with partial assignment evaluation T2 - Proceedings of the Design, Automation & Test in Europe Conference & Exhibition (DATE), 2017 N2 - The design of embedded systems is becoming continuously more complex such that efficient system-level design methods are becoming crucial. Recently, combined Answer Set Programming (ASP) and Quantifier Free Integer Difference Logic (QF-IDL) solving has been shown to be a promising approach in system synthesis. However, this approach still has several restrictions limiting its applicability. In the paper at hand, we propose a novel ASP modulo Theories (ASPmT) system synthesis approach, which (i) supports more sophisticated system models, (ii) tightly integrates the QF-IDL solving into the ASP solving, and (iii) makes use of partial assignment checking. As a result, more realistic systems are considered and an early exclusion of infeasible solutions improves the entire system synthesis. Y1 - 2017 SN - 978-3-9815370-9-3 U6 - https://doi.org/10.23919/DATE.2017.7927005 SN - 1530-1591 SP - 306 EP - 309 PB - IEEE CY - New York ER - TY - GEN A1 - Staubitz, Thomas A1 - Wilkins, Christian A1 - Hagedorn, Christiane A1 - Meinel, Christoph T1 - The Gamification of a MOOC Platform T2 - Proceedings of 2017 IEEE Global Engineering Education Conference (EDUCON) N2 - Massive Open Online Courses (MOOCs) have left their mark on the face of education during the recent years. At the Hasso Plattner Institute (HPI) in Potsdam, Germany, we are actively developing a MOOC platform, which provides our research with a plethora of e-learning topics, such as learning analytics, automated assessment, peer assessment, team-work, online proctoring, and gamification. We run several instances of this platform. On openHPI, we provide our own courses from within the HPI context. Further instances are openSAP, openWHO, and mooc.HOUSE, which is the smallest of these platforms, targeting customers with a less extensive course portfolio. In 2013, we started to work on the gamification of our platform. By now, we have implemented about two thirds of the features that we initially have evaluated as useful for our purposes. About a year ago we activated the implemented gamification features on mooc.HOUSE. Before activating the features on openHPI as well, we examined, and re-evaluated our initial considerations based on the data we collected so far and the changes in other contexts of our platforms. KW - MOOC KW - Gamification KW - e-learning KW - Massive Open Online Courses Y1 - 2017 SN - 978-1-5090-5467-1 U6 - https://doi.org/10.1109/EDUCON.2017.7942952 SN - 2165-9567 SP - 883 EP - 892 PB - IEEE CY - New York ER - TY - GEN A1 - Thoelert, Steffen A1 - Hörmann, Ulrich A1 - Antreich, Felix A1 - Meurer, Michael T1 - Ionospheric effects on high gain antenna GNSS measurements BT - TEC estimation and correction T2 - Proceedings of the 30th International Technical Meeting of the Satellite Division of The Institute of Navigation (ION GNSS+ 2017) N2 - The ionospheric delay of global navigation satellite systems (GNSS) signals typically is compensated by adding a single correction value to the pseudorange measurement of a GNSS receiver. Yet, this neglects the dispersive nature of the ionosphere. In this context we analyze the ionospheric signal distortion beyond a constant delay. These effects become increasingly significant with the signal bandwidth and hence more important for new broadband navigation signals. Using measurements of the Galileo E5 signal, captured with a high gain antenna, we verify that the expected influence can indeed be observed and compensated. A new method to estimate the total electron content (TEC) from a single frequency high gain antenna measurement of a broadband GNSS signal is proposed and described in detail. The received signal is de facto unaffected by multi-path and interference because of the narrow aperture angle of the used antenna which should reduce the error source of the result in general. We would like to point out that such measurements are independent of code correlation, like in standard receiver applications. It is therefore also usable without knowledge of the signal coding. Results of the TEC estimation process are shown and discussed comparing to common TEC products like TEC maps and dual frequency receiver estimates. Y1 - 2017 U6 - https://doi.org/10.33012/2017.15343 SN - 2331-5911 SN - 2331-5954 SP - 3368 EP - 3374 PB - Instituite of Navigation CY - Washington ER - TY - GEN A1 - Laubrock, Jochen A1 - Engbert, Ralf A1 - Cajar, Anke T1 - Gaze-contingent manipulation of the FVF demonstrates the importance of fixation duration for explaining search behavior T2 - Behavioral and brain sciences : an international journal of current research and theory with open peer commentary N2 - Hulleman & Olivers' (H&O's) model introduces variation of the functional visual field (FVF) for explaining visual search behavior. Our research shows how the FVF can be studied using gaze-contingent displays and how FVF variation can be implemented in models of gaze control. Contrary to H&O, we believe that fixation duration is an important factor when modeling visual search behavior. Y1 - 2017 U6 - https://doi.org/10.1017/S0140525X16000145 SN - 0140-525X SN - 1469-1825 VL - 40 SP - 31 EP - 32 PB - Cambridge Univ. Press CY - New York ER - TY - GEN A1 - Fabian, Benjamin A1 - Baumann, Annika A1 - Ehlert, Mathias A1 - Ververis, Vasilis A1 - Ermakova, Tatiana T1 - CORIA - Analyzing internet connectivity risks using network graphs T2 - 2017 IEEE International Conference on Communications (ICC) N2 - The Internet can be considered as the most important infrastructure for modern society and businesses. A loss of Internet connectivity has strong negative financial impacts for businesses and economies. Therefore, assessing Internet connectivity, in particular beyond their own premises and area of direct control, is of growing importance in the face of potential failures, accidents, and malicious attacks. This paper presents CORIA, a software framework for an easy analysis of connectivity risks based on large network graphs. It provides researchers, risk analysts, network managers and security consultants with a tool to assess an organization's connectivity and paths options through the Internet backbone, including a user-friendly and insightful visual representation of results. CORIA is flexibly extensible in terms of novel data sets, graph metrics, and risk scores that enable further use cases. The performance of CORIA is evaluated by several experiments on the Internet graph and further randomly generated networks. KW - risk analysis KW - connectivity KW - graph analysis KW - complex networks KW - Internet Y1 - 2017 SN - 978-1-4673-8999-0 SN - 978-1-4673-9000-2 U6 - https://doi.org/10.1109/ICC.2017.7996828 SN - 1550-3607 PB - IEEE CY - Piscataway ER - TY - GEN A1 - Grossi, Giuseppe A1 - Reichard, Christoph A1 - Thomasson, Anna A1 - Vakkuri, Jarmo T1 - Editorial T2 - Public money & management : integrating theory and practice in public management Y1 - 2017 U6 - https://doi.org/10.1080/09540962.2017.1344007 SN - 0954-0962 SN - 1467-9302 VL - 37 SP - 379 EP - 386 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - GEN A1 - Hass, Roland A1 - Sandmann, Michael A1 - Reich, Oliver T1 - Photonic sensing in highly concentrated biotechnical processes by photon density wave spectroscopy T2 - Proceedings SPIE 10323, 25th International Conference on Optical Fiber Sensors N2 - Photon Density Wave (PDW) spectroscopy is introduced as a new approach for photonic sensing in highly concentrated biotechnical processes. It independently quantifies the absorption and reduced scattering coefficient calibration-free and as a function of time, thus describing the optical properties in the vis/NIR range of the biomaterial during their processing. As examples of industrial relevance, enzymatic milk coagulation, beer mashing, and algae cultivation in photo bioreactors are discussed. KW - Photon Density Wave Spectroscopy KW - multiple light scattering KW - fermentation KW - algae cultivation KW - process analytical technology KW - fiber spectroscopy Y1 - 2017 SN - 978-1-5090-4850-2 U6 - https://doi.org/10.1117/12.2263617 SN - 0277-786X SN - 1996-756X VL - 10323 PB - IEEE CY - New York ER - TY - GEN A1 - Loupos, Konstantinos A1 - Damigos, Yannis A1 - Amditis, Angelos A1 - Gerhard, Reimund A1 - Rychkov, Dmitry A1 - Wirges, Werner A1 - Schulze, Manuel A1 - Lenas, Sotiris-Angelos A1 - Chatziandreoglou, Christos A1 - Malliou, Christina A1 - Tsaoussidis, Vassilis A1 - Brady, Ken A1 - Frankenstein, Bernd T1 - Structural health monitoring system for bridges based on skin-like sensor T2 - IOP conference series : Materials science and engineering N2 - Structural health monitoring activities are of primal importance for managing transport infrastructure, however most SHM methodologies are based on point-based sensors that have limitations in terms of their spatial positioning requirements, cost of development and measurement range. This paper describes the progress on the SENSKIN EC project whose objective is to develop a dielectric-elastomer and micro-electronics-based sensor, formed from a large highly extensible capacitance sensing membrane supported by advanced microelectronic circuitry, for monitoring transport infrastructure bridges. Such a sensor could provide spatial measurements of strain in excess of 10%. The actual sensor along with the data acquisition module, the communication module and power electronics are all integrated into a compact unit, the SENSKIN device, which is energy-efficient, requires simple signal processing and it is easy to install over various surface types. In terms of communication, SENSKIN devices interact with each other to form the SENSKIN system; a fully distributed and autonomous wireless sensor network that is able to self-monitor. SENSKIN system utilizes Delay-/Disruption-Tolerant Networking technologies to ensure that the strain measurements will be received by the base station even under extreme conditions where normal communications are disrupted. This paper describes the architecture of the SENSKIN system and the development and testing of the first SENSKIN prototype sensor, the data acquisition system, and the communication system. Y1 - 2017 U6 - https://doi.org/10.1088/1757-899X/236/1/012100 SN - 1757-8981 VL - 236 PB - IOP Publ. Ltd. CY - Bristol ER - TY - GEN A1 - Nguyen, Vu Hoa A1 - Richert, S. A1 - Park, Hyunji A1 - Böker, Alexander A1 - Schnakenberg, Uwe T1 - Single interdigital transducer as surface acoustic wave impedance sensor T2 - Biosensors N2 - Surface acoustic wave (SAW) devices are well-known for gravimetric sensor applications. In biosensing applications, chemical-and biochemically evoked adsorption processes at surfaces are detected in liquid environments using delay-line or resonator sensor configurations, preferably in combination with appropriate microfluidic devices. In this paper, a novel SAW-based impedance sensor type is introduced which uses only one interdigital electrode transducer (IDT) simultaneously as SAW generator and sensor element. It is shown that the amplitude of the reflected S-11 signal directly depends on the input impedance of the SAW device. The input impedance is strongly influenced by mass adsorption which causes a characteristic and measurable impedance mismatch. KW - SAW impedance sensor KW - microfluidic KW - PHEMA Y1 - 2017 U6 - https://doi.org/10.1016/j.protcy.2017.04.032 SN - 2212-0173 VL - 27 SP - 70 EP - 71 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Schmidt-Hattenberger, Cornelia A1 - Bergmann, Peter A1 - Labitzke, Tim A1 - Pommerencke, Julia A1 - Rippe, Dennis A1 - Wagner, Florian A1 - Wiese, Bernd T1 - Monitoring the complete life-cycle of a CO2 storage reservoir-Demonstration of applicability of geoelectrical imaging T2 - 13th International Conference on Greenhouse Gas Control Technologies (GHGT) N2 - In this paper, the applicability of deep downhole geoelectrical monitoring for detecting CO2 related signatures is evaluated after a nearly ten year period of CO2 storage at the Ketzin pilot site. Deep downhole electrode arrays have been studied as part of a multi-physical monitoring concept at four CO2 pilot test sites worldwide so far. For these sites, it was considered important to implement the geoelectrical method into the measurement program of tracking the CO2 plume. Analyzing the example of the Ketzin site, it can be seen that during all phases of the CO2 storage reservoir development the resistivity measurements and their corresponding tomographic interpretation contribute in a beneficial manner to the measurement, monitoring and verification (MMV) protocol. The most important impact of a permanent electrode array is its potential as tool for estimating reservoir saturations. KW - Geoeletrical imaging KW - permanent downhole electrode array KW - CO2 storage monitoring Y1 - 2017 U6 - https://doi.org/10.1016/j.egypro.2017.03.1526 SN - 1876-6102 VL - 114 SP - 3948 EP - 3955 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Kühn, Michael A1 - Schöne, Tim T1 - Multivariate regression model from water level and production rate time series for the geothermal reservoir Waiwera (New Zealand) T2 - Energy procedia N2 - Water management tools are necessary to guarantee the preservation of natural resources while ensuring optimum utilization. Linear regression models are a simple and quick solution for creating prognostic capabilities. Multivariate models show higher precision than univariate models. In the case of Waiwera, implementation of individual production rates is more accurate than applying just the total production rate. A maximum of approximately 1,075 m3/day can be pumped to ensure a water level of at least 0.5 m a.s.l. in the monitoring well. The model should be renewed annually to implement new data and current water level trends to keep the quality. KW - geothermal reservoir KW - water management KW - data based model KW - multivariate regression KW - coefficient of determination KW - scenario analysis Y1 - 2017 U6 - https://doi.org/10.1016/j.egypro.2017.08.196 SN - 1876-6102 VL - 125 SP - 571 EP - 579 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Wetzel, Maria A1 - Kempka, Thomas A1 - Kühn, Michael T1 - Predicting macroscopic elastic rock properties requires detailed information on microstructure T2 - Energy procedia N2 - Predicting variations in macroscopic mechanical rock behaviour due to microstructural changes, driven by mineral precipitation and dissolution is necessary to couple chemo-mechanical processes in geological subsurface simulations. We apply 3D numerical homogenization models to estimate Young’s moduli for five synthetic microstructures, and successfully validate our results for comparable geometries with the analytical Mori-Tanaka approach. Further, we demonstrate that considering specific rock microstructures is of paramount importance, since calculated elastic properties may deviate by up to 230 % for the same mineral composition. Moreover, agreement between simulated and experimentally determined Young’s moduli is significantly improved, when detailed spatial information are employed. KW - digital rock physics KW - effective elastic properties KW - numerical Y1 - 2017 U6 - https://doi.org/10.1016/j.egypro.2017.08.195 SN - 1876-6102 VL - 125 SP - 561 EP - 570 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Kühn, Michael A1 - Li, Qi A1 - Nakaten, Natalie Christine A1 - Kempka, Thomas T1 - Integrated subsurface gas storage of CO2 and CH4 offers capacity and state-of-the-art technology for energy storage in China T2 - Energy procedia N2 - Integration and development of the energy supply in China and worldwide is a challenge for the years to come. The innovative idea presented here is based on an extension of the “power-to-gas-to-power” technology by establishing a closed carbon cycle. It is an implementation of a low-carbon energy system based on carbon dioxide capture and storage (CCS) to store and reuse wind and solar energy. The Chenjiacun storage project in China compares well with the German case study for the towns Potsdam and Brandenburg/Havel in the Federal State of Brandenburg based on the Ketzin pilot site for CCS. KW - gas storage KW - carbon dioxide KW - methane KW - hydrogen KW - renewable energy KW - carbon cycle Y1 - 2017 U6 - https://doi.org/10.1016/j.egypro.2017.08.039 SN - 1876-6102 VL - 125 SP - 14 EP - 18 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Kühn, Michael A1 - Kempka, Thomas A1 - de Lucia, Marco A1 - Scheck-Wenderoth, Magdalena T1 - Dissolved CO2 storage in geological formations with low pressure, low risk and large capacities T2 - Energy procedia N2 - Geological CO2 storage is a mitigation technology to reduce CO2 emissions from fossil fuel combustion. However, major concerns are the pressure increase and saltwater displacement in the mainly targeted deep groundwater aquifers due to injection of supercritical CO2. The suggested solution is storage of CO2 exclusively in the dissolved state. In our exemplary regional case study of the North East German Basin based on a highly resolved temperature and pressure distribution model and a newly developed reactive transport coupling, we have quantified that 4.7 Gt of CO2 can be stored in solution compared to 1.5 Gt in the supercritical state. KW - carbon dioxide KW - dissolved KW - storage capacity KW - numerical simulation KW - saline aquifer KW - Buntsandstein Y1 - 2017 U6 - https://doi.org/10.1016/j.egypro.2017.03.1607 SN - 1876-6102 VL - 114 SP - 4722 EP - 4727 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Plauth, Max A1 - Sterz, Christoph A1 - Eberhardt, Felix A1 - Feinbube, Frank A1 - Polze, Andreas T1 - Assessing NUMA performance based on hardware event counters T2 - IEEE International Parallel and Distributed Processing Symposium Workshops (IPDPSW) N2 - Cost models play an important role for the efficient implementation of software systems. These models can be embedded in operating systems and execution environments to optimize execution at run time. Even though non-uniform memory access (NUMA) architectures are dominating today's server landscape, there is still a lack of parallel cost models that represent NUMA system sufficiently. Therefore, the existing NUMA models are analyzed, and a two-step performance assessment strategy is proposed that incorporates low-level hardware counters as performance indicators. To support the two-step strategy, multiple tools are developed, all accumulating and enriching specific hardware event counter information, to explore, measure, and visualize these low-overhead performance indicators. The tools are showcased and discussed alongside specific experiments in the realm of performance assessment. KW - Parallel programming KW - Performance analysis KW - Memory management Y1 - 2017 SN - 978-0-7695-6149-3 U6 - https://doi.org/10.1109/IPDPSW.2017.51 SN - 2164-7062 SP - 904 EP - 913 PB - Institute of Electrical and Electronics Engineers CY - New York ER - TY - GEN A1 - Torkura, Kennedy A. A1 - Sukmana, Muhammad Ihsan Haikal A1 - Cheng, Feng A1 - Meinel, Christoph T1 - Leveraging cloud native design patterns for security-as-a-service applications T2 - IEEE International Conference on Smart Cloud (SmartCloud) N2 - This paper discusses a new approach for designing and deploying Security-as-a-Service (SecaaS) applications using cloud native design patterns. Current SecaaS approaches do not efficiently handle the increasing threats to computer systems and applications. For example, requests for security assessments drastically increase after a high-risk security vulnerability is disclosed. In such scenarios, SecaaS applications are unable to dynamically scale to serve requests. A root cause of this challenge is employment of architectures not specifically fitted to cloud environments. Cloud native design patterns resolve this challenge by enabling certain properties e.g. massive scalability and resiliency via the combination of microservice patterns and cloud-focused design patterns. However adopting these patterns is a complex process, during which several security issues are introduced. In this work, we investigate these security issues, we redesign and deploy a monolithic SecaaS application using cloud native design patterns while considering appropriate, layered security counter-measures i.e. at the application and cloud networking layer. Our prototype implementation out-performs traditional, monolithic applications with an average Scanner Time of 6 minutes, without compromising security. Our approach can be employed for designing secure, scalable and performant SecaaS applications that effectively handle unexpected increase in security assessment requests. KW - Cloud-Security KW - Security-as-a-Service KW - Vulnerability Assessment KW - Cloud Native Applications Y1 - 2017 SN - 978-1-5386-3684-8 U6 - https://doi.org/10.1109/SmartCloud.2017.21 SP - 90 EP - 97 PB - Institute of Electrical and Electronics Engineers CY - New York ER - TY - GEN A1 - Limberger, Daniel A1 - Scheibel, Willy A1 - Trapp, Matthias A1 - Döllner, Jürgen Roland Friedrich T1 - Mixed-projection treemaps BT - a novel approach mixing 2D and 2.5D treemaps T2 - 21st International Conference Information Visualisation (IV) N2 - This paper presents a novel technique for combining 2D and 2.5D treemaps using multi-perspective views to leverage the advantages of both treemap types. It enables a new form of overview+detail visualization for tree-structured data and contributes new concepts for real-time rendering of and interaction with treemaps. The technique operates by tilting the graphical elements representing inner nodes using affine transformations and animated state transitions. We explain how to mix orthogonal and perspective projections within a single treemap. Finally, we show application examples that benefit from the reduced interaction overhead. KW - Information Visualization KW - Overview plus Detail KW - Treemaps KW - 2.5D Treemaps KW - Multi-perspective Views Y1 - 2017 SN - 978-1-5386-0831-9 U6 - https://doi.org/10.1109/iV.2017.67 SN - 2375-0138 SP - 164 EP - 169 PB - Institute of Electrical and Electronics Engineers CY - Los Alamitos ER - TY - GEN A1 - Saint-Dizier, Patrick A1 - Stede, Manfred T1 - Foundations of the language of argumentation T2 - Argument & computation Y1 - 2017 U6 - https://doi.org/10.3233/AAC-170018 SN - 1946-2166 SN - 1946-2174 VL - 8 IS - 2 Special issue SP - 91 EP - 93 PB - IOS Press CY - Amsterdam ER - TY - GEN A1 - Waldrip, Steven H. A1 - Niven, Robert K. A1 - Abel, Markus A1 - Schlegel, Michael T1 - Consistent maximum entropy representations of pipe flow networks T2 - AIP conference proceedings N2 - The maximum entropy method is used to predict flows on water distribution networks. This analysis extends the water distribution network formulation of Waldrip et al. (2016) Journal of Hydraulic Engineering (ASCE), by the use of a continuous relative entropy defined on a reduced parameter set. This reduction in the parameters that the entropy is defined over ensures consistency between different representations of the same network. The performance of the proposed reduced parameter method is demonstrated with a one-loop network case study. Y1 - 2017 SN - 978-0-7354-1527-0 U6 - https://doi.org/10.1063/1.4985365 SN - 0094-243X VL - 1853 IS - 1 PB - American Institute of Physics CY - Melville ER - TY - GEN A1 - Waldrip, Steven H. A1 - Niven, Robert K. A1 - Abel, Markus A1 - Schlegel, Michael T1 - Maximum entropy analysis of transport networks T2 - AIP conference proceedings N2 - The maximum entropy method is used to derive an alternative gravity model for a transport network. The proposed method builds on previous methods which assign the discrete value of a maximum entropy distribution to equal the traffic flow rate. The proposed method however, uses a distribution to represent each flow rate. The proposed method is shown to be able to handle uncertainty in a more elegant way and give similar results to traditional methods. It is able to incorporate more of the observed data through the entropy function, prior distribution and integration limits potentially allowing better inferences to be made. Y1 - 2017 SN - 978-0-7354-1527-0 U6 - https://doi.org/10.1063/1.4985364 SN - 0094-243X VL - 1853 IS - 1 PB - American Institute of Physics CY - Melville ER - TY - GEN A1 - Gronau, Norbert A1 - Ullrich, André A1 - Teichmann, Malte T1 - Development of the industrial IoT competences in the areas of organization, process, and interaction based on the learning factory concept T2 - Procedia manufacturing N2 - Lately, first implementation approaches of Internet of Things (IoT) technologies penetrate industrial value-adding processes. Within this, the competence requirements for employees are changing. Employees’ organization, process, and interaction competences are of crucial importance in this new IoT environment, however, in students and vocational training not sufficiently considered yet. On the other hand, conventional learning factories evolve and transform to digital learning factories. Nevertheless, the integration of IoT technology and its usage for training in digital learning factories has been largely neglected thus far. Existing learning factories do not explicitly and properly consider IoT technology, which leads to deficiencies regarding an appropriate development of employees’ Industrial IoT competences. The goal of this contribution is to point out a didactic concept that enables development and training of these new demanded competences by using an IoT laboratory. For this purpose, a design science approach is applied. The result of this contribution is a didactic concept for the development of Industrial IoT competences in an IoT laboratory. KW - Digital Learning Factory KW - Industrial IoT Competences KW - Student Training KW - Vocational Training Y1 - 2017 U6 - https://doi.org/10.1016/j.promfg.2017.04.029 SN - 2351-9789 VL - 9 SP - 254 EP - 261 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Kay, Alex James T1 - Disagreement is fine. Misrepresentation is not BT - response to John Morello T2 - The international history review Y1 - 2017 U6 - https://doi.org/10.1080/07075332.2017.1354547 SN - 0707-5332 SN - 1949-6540 VL - 39 SP - 929 EP - 930 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - GEN A1 - Giese, Holger ED - Kouchnarenko, Olga ED - Khosravi, Ramtin T1 - Formal models and analysis for self-adaptive cyber-physical systems BT - (extended abstract) T2 - Lecture notes in computer science N2 - In this extended abstract, we will analyze the current challenges for the envisioned Self-Adaptive CPS. In addition, we will outline our results to approach these challenges with SMARTSOS [10] a generic approach based on extensions of graph transformation systems employing open and adaptive collaborations and models at runtime for trustworthy self-adaptation, self-organization, and evolution of the individual systems and the system-of-systems level taking the independent development, operation, management, and evolution of these systems into account. Y1 - 2017 SN - 978-3-319-57666-4 SN - 978-3-319-57665-7 U6 - https://doi.org/10.1007/978-3-319-57666-4_1 SN - 0302-9743 SN - 1611-3349 VL - 10231 SP - 3 EP - 9 PB - Springer CY - Cham ER - TY - GEN A1 - Serth, Sebastian A1 - Podlesny, Nikolai A1 - Bornstein, Marvin A1 - Lindemann, Jan A1 - Latt, Johanna A1 - Selke, Jan A1 - Schlosser, Rainer A1 - Boissier, Martin A1 - Uflacker, Matthias T1 - An interactive platform to simulate dynamic pricing competition on online marketplaces T2 - 2017 IEEE 21st International Enterprise Distributed Object Computing Conference (EDOC) N2 - E-commerce marketplaces are highly dynamic with constant competition. While this competition is challenging for many merchants, it also provides plenty of opportunities, e.g., by allowing them to automatically adjust prices in order to react to changing market situations. For practitioners however, testing automated pricing strategies is time-consuming and potentially hazardously when done in production. Researchers, on the other side, struggle to study how pricing strategies interact under heavy competition. As a consequence, we built an open continuous time framework to simulate dynamic pricing competition called Price Wars. The microservice-based architecture provides a scalable platform for large competitions with dozens of merchants and a large random stream of consumers. Our platform stores each event in a distributed log. This allows to provide different performance measures enabling users to compare profit and revenue of various repricing strategies in real-time. For researchers, price trajectories are shown which ease evaluating mutual price reactions of competing strategies. Furthermore, merchants can access historical marketplace data and apply machine learning. By providing a set of customizable, artificial merchants, users can easily simulate both simple rule-based strategies as well as sophisticated data-driven strategies using demand learning to optimize their pricing strategies. Y1 - 2017 SN - 978-1-5090-3045-3 U6 - https://doi.org/10.1109/EDOC.2017.17 SN - 2325-6354 SP - 61 EP - 66 PB - Institute of Electrical and Electronics Engineers CY - New York ER - TY - GEN A1 - Low, Thomas A1 - Hentschel, Christian A1 - Stober, Sebastian A1 - Sack, Harald A1 - Nürnberger, Andreas ED - Amsaleg, Laurent ED - Guðmundsson, Gylfi Þór ED - Gurrin, Cathal ED - Jónsson, Björn Þór ED - Satoh, Shin'ichi T1 - Exploring large movie collections BT - comparing visual berrypicking and traditional browsing T2 - Lecture notes in computer science N2 - We compare Visual Berrypicking, an interactive approach allowing users to explore large and highly faceted information spaces using similarity-based two-dimensional maps, with traditional browsing techniques. For large datasets, current projection methods used to generate maplike overviews suffer from increased computational costs and a loss of accuracy resulting in inconsistent visualizations. We propose to interactively align inexpensive small maps, showing local neighborhoods only, which ideally creates the impression of panning a large map. For evaluation, we designed a web-based prototype for movie exploration and compared it to the web interface of The Movie Database (TMDb) in an online user study. Results suggest that users are able to effectively explore large movie collections by hopping from one neighborhood to the next. Additionally, due to the projection of movie similarities, interesting links between movies can be found more easily, and thus, compared to browsing serendipitous discoveries are more likely. KW - Exploratory interfaces KW - Media retrieval KW - Multidimensional scaling KW - User study Y1 - 2016 SN - 978-3-319-51814-5 SN - 978-3-319-51813-8 U6 - https://doi.org/10.1007/978-3-319-51814-5_17 SN - 0302-9743 SN - 1611-3349 VL - 10133 SP - 198 EP - 208 PB - Springer CY - Cham ER - TY - GEN A1 - Fraschetti, Federico A1 - Pohl, Martin T1 - Two-zone model for the broadband crab nebula spectrum BT - microscopic interpretation T2 - The European physical journal : Web of Conferences : proceedings N2 - We develop a simple two-zone interpretation of the broadband baseline Crab nebula spectrum between 10(-5) eV and similar to 100 TeV by using two distinct log-parabola energetic electrons distributions. We determine analytically the very-high energy photon spectrum as originated by inverse-Compton scattering of the far-infrared soft ambient photons within the nebula off a first population of electrons energized at the nebula termination shock. The broad and flat 200 GeV peak jointly observed by Fermi/LAT and MAGIC is naturally reproduced. The synchrotron radiation from a second energetic electron population explains the spectrum from the radio range up to similar to 10 keV. We infer from observations the energy dependence of the microscopic probability of remaining in proximity of the shock of the accelerating electrons. Y1 - 2017 U6 - https://doi.org/10.1051/epjconf/201713602009 SN - 2100-014X VL - 136 PB - EDP Sciences CY - Les Ulis ER - TY - GEN A1 - Renz, Jan A1 - Shams, Ahmed A1 - Meinel, Christoph T1 - Offline-Enabled Web-based E-Learning for Improved User Experience in Africa T2 - 2017 IEEE Africon N2 - Web-based E-Learning uses Internet technologies and digital media to deliver education content to learners. Many universities in recent years apply their capacity in producing Massive Open Online Courses (MOOCs). They have been offering MOOCs with an expectation of rendering a comprehensive online apprenticeship. Typically, an online content delivery process requires an Internet connection. However, access to the broadband has never been a readily available resource in many regions. In Africa, poor and no networks are yet predominantly experienced by Internet users, frequently causing offline each moment a digital device disconnect from a network. As a result, a learning process is always disrupted, delayed and terminated in such regions. This paper raises the concern of E-Learning in poor and low bandwidths, in fact, it highlights the needs for an Offline-Enabled mode. The paper also explores technical approaches beamed to enhance the user experience inWeb-based E-Learning, particular in Africa. KW - Educational Technology KW - E-Learning KW - Internet KW - Bandwidth KW - Mobile Learning KW - Mobiles KW - MOOC KW - Offline-Enabled KW - Ubiquitous Y1 - 2017 SN - 978-1-5386-2775-4 U6 - https://doi.org/10.1109/AFRCON.2017.8095574 SN - 2153-0025 SP - 736 EP - 742 PB - IEEE CY - New York ER - TY - GEN A1 - Kocyan, Alexander A1 - Wiland-Szymanska, Justyna T1 - A new name and a new combination for Friedmannia nom. illeg. (Hypoxidaceae) T2 - Phytotaxa : a rapid international journal for accelerating the publication of botanical taxonomy N2 - Recently, Kocyan & Wiland-Szymańska (2016) have published a thorough research article on one of the outstanding members of the family Hypoxidaceae on the Seychelles, which resulted in the raise of a new genus (Friedmannia Kocyan & Wiland-Szymańska 2016: 60) to accommodate the former Curculigo seychellensis Bojer ex Baker (1877: 368). However, it has turned out that the name Friedmannia Chantanachat & Bold (1962: 45) already exists in literature for a green alga, which renders the new hypoxid genus illegitimate (Melbourne Code; McNeill et al. 2012). Therefore, we assign a new generic epithet to Curculigo seychellensis. Y1 - 2017 U6 - https://doi.org/10.11646/phytotaxa.291.3.10 SN - 1179-3155 SN - 1179-3163 VL - 291 IS - 3 SP - 239 EP - 239 PB - Magnolia Press CY - Auckland ER - TY - GEN A1 - Wang, Yongbo A1 - Herzschuh, Ulrike A1 - Liu, Xingqi A1 - Korup, Oliver A1 - Diekmann, Bernhard T1 - Reply to Chong Xu’s comment on: Wang, Yongbo; Herzschuh, Ulrike; Liu, Xingqi; Korup, Oliver; Diekmann, Bernhard: A high-resolution sedimentary archive from landslide-dammed Lake Mengda, north-eastern Tibetan Plateau. - Journal of Paleolimnology. - 51 (2014), S. 303 - 312 T2 - Journal of paleolimnolog Y1 - 2016 U6 - https://doi.org/10.1007/s10933-016-9937-8 SN - 0921-2728 SN - 1573-0417 VL - 57 SP - 163 EP - 164 PB - Springer CY - Dordrecht ER - TY - GEN A1 - Penk, Christiane A1 - Richter, Dirk T1 - Erratum to: Penk, Christiane, Richter, Dirk: Change in test-taking motivation and its relationship to test performance in low-stakes assessments. - (Educational Assessment, Evaluation and Accountability. - 29 (2017), S. 55 – 79. - doi.org/10.1007/s11092-016-9248-7) T2 - Educational assessment, evaluation and accountability Y1 - 2016 U6 - https://doi.org/10.1007/s11092-016-9249-6 SN - 1874-8597 SN - 1874-8600 VL - 29 SP - 81 EP - 82 PB - Springer CY - Heidelberg ER - TY - GEN A1 - George, Elizabeth A1 - Kearney, Eric T1 - Editorial T2 - Organizational psychology review Y1 - 2017 U6 - https://doi.org/10.1177/2041386617690945 SN - 2041-3866 SN - 2041-3874 VL - 7 IS - 1 SP - 3 EP - 3 PB - Sage Publ. CY - Thousand Oaks ER - TY - GEN A1 - Grisic, Ana-Marija A1 - Huisinga, Wilhelm A1 - Reinisch, W. A1 - Kloft, Charlotte T1 - P485 Dosing infliximab in Crohn's disease BT - is adjustment for body size justified? T2 - Journal of Crohn's and Colitis N2 - Background: Infliximab (IFX), an anti-TNF monoclonal antibody approved for the treatment of inflammatory bowel disease, is dosed per kg body weight (BW). However, the rationale for body size adjustment has not been unequivocally demonstrated [1], and first attempts to improve IFX therapy have been undertaken [2]. The aim of our study was to assess the impact of different dosing strategies (i.e. body size-adjusted and fixed dosing) on drug exposure and pharmacokinetic (PK) target attainment. For this purpose, a comprehensive simulation study was performed, using patient characteristics (n=116) from an in-house clinical database. Methods: IFX concentration-time profiles of 1000 virtual, clinically representative patients were generated using a previously published PK model for IFX in patients with Crohn's disease [3]. For each patient 1000 profiles accounting for PK variability were considered. The IFX exposure during maintenance treatment after the following dosing strategies was compared: i) fixed dose, and per ii) BW, iii) lean BW (LBW), iv) body surface area (BSA), v) height (HT), vi) body mass index (BMI) and vii) fat-free mass (FFM)). For each dosing strategy the variability in maximum concentration Cmax, minimum concentration Cmin (= C8weeks) and area under the concentration-time curve (AUC), as well as percent of patients achieving the PK target, Cmin=3 μg/mL [4] were assessed. Results: For all dosing strategies the variability of Cmin (CV ≈110%) was highest, compared to Cmax and AUC, and was of similar extent regardless of dosing strategy. The proportion of patients reaching the PK target (≈⅓ was approximately equal for all dosing strategies. Y1 - 2017 U6 - https://doi.org/10.1093/ecco-jcc/jjx002.609 SN - 1873-9946 SN - 1876-4479 VL - 11 IS - 1 SP - S325 EP - S326 PB - Oxford Univ. Press CY - Oxford ER - TY - GEN A1 - Metzler, Ralf T1 - Anomalous Diffusion in Membranes and the Cytoplasm of Biological Cells T2 - Biophysical journal Y1 - 2017 U6 - https://doi.org/10.1016/j.bpj.2016.11.2577 SN - 0006-3495 SN - 1542-0086 VL - 112 IS - 3 SP - 476A EP - 476A PB - Cell Press CY - Cambridge ER - TY - GEN A1 - Metzler, Ralf T1 - Gaussianity Fair BT - the Riddle of Anomalous yet Non-Gaussian Diffusion T2 - Biophysical journal Y1 - 2017 U6 - https://doi.org/10.1016/j.bpj.2016.12.019 SN - 0006-3495 SN - 1542-0086 VL - 112 IS - 3 SP - 413 EP - 415 PB - Cell Press CY - Cambridge ER - TY - GEN A1 - Felser, Claudia A1 - Phillips, Colin A1 - Wagers, Matthew T1 - Editorial: Encoding and Navigating Linguistic Representations in Memory T2 - Frontiers in psychology KW - sentence comprehension KW - encoding KW - memory retrieval KW - interference KW - anaphor resolution KW - agreement processing KW - filler-gap dependencies Y1 - 2017 U6 - https://doi.org/10.3389/fpsyg.2017.00164 SN - 1664-1078 VL - 8 PB - Frontiers Research Foundation CY - Lausanne ER - TY - GEN A1 - Paycha, Sylvie T1 - Interview with Pierre Cartier BT - Potsdam, December 4th, 2014 T2 - The mathematical intelligencer Y1 - 2016 U6 - https://doi.org/10.1007/s00283-016-9673-y SN - 0343-6993 SN - 1866-7414 VL - 39 SP - 15 EP - 21 PB - Springer CY - New York ER - TY - GEN A1 - Koziel, Slawomir A1 - Hermanussen, Michael A1 - Gomula, Alexandra A1 - Swanson, James A1 - Kaczmarek, Maria A1 - El-Shabrawi, Mortada A1 - Elhusseini, Mona A1 - Satake, Takashi A1 - Martinovic Klaric, Irena A1 - Scheffler, Christiane A1 - Morkuniene, Ruta A1 - Godina, Elena A1 - Sasa, Missoni A1 - Tutkuviene, Janina A1 - Siniarska, Anna A1 - Nieczuja-Dwojacka, Joanna A1 - Nunez, Javier A1 - Groth, Detlef A1 - Barbieri, Davide T1 - Adolescence - a Transition to Adulthood Proceedings of the 24th Aschauer Soiree, held at Jurata, Poland, November 5th 2016 T2 - Pediatric Endocrinology Reviews N2 - Eighteen scientists met at Jurata, Poland, to discuss various aspects of the transition from adolescence to adulthood. This transition is a delicate period facing complex interactions between the adolescents and the social group they belong to. Social identity, group identification and identity signalling, but also stress affecting basal salivary cortisol rhythms, hypertension, inappropriate nutrition causing latent and manifest obesity, moreover, in developing and under-developed countries, parasitosis causing anaemia thereby impairing growth and development, are issues to be dealt with during this period of the human development. In addition, some new aspects of the association between weight, height and head circumference in the newborns were discussed, as well as intrauterine head growth and head circumference as health risk indicators. KW - Strategic growth adjustment KW - BMI KW - Growth faltering KW - Secular trend KW - Obesity KW - Growth modelling Y1 - 2017 SN - 1565-4753 VL - 14 IS - 3 SP - 326 EP - 334 PB - Medical Media CY - Netanya ER -