TY - JOUR A1 - Caliendo, Marco A1 - Mahlstedt, Robert A1 - van den Berg, Gerard J. A1 - Vikström, Johan T1 - Side effects of labor market policies JF - The Scandinavian journal of economics N2 - Labor market policies, such as training and sanctions, are commonly used to bring workers back to work. By analogy to medical treatments, exposure to these tools can have side effects. We study the effects on health using individual-level population registers on labor market outcomes, drug prescriptions, and sickness absence, comparing outcomes before and after exposure to training and sanctions. Training improves cardiovascular and mental health, and lowers sickness absence. This is likely to be the result of the instantaneous features of participation, such as the adoption of a more rigorous daily routine, rather than improved employment prospects. Benefits sanctions cause a short-run deterioration of mental health. KW - Cardiovascular disease KW - depression KW - drugs KW - health KW - mental health KW - prescriptions KW - sanctions KW - sickness KW - training KW - unemployment Y1 - 2022 U6 - https://doi.org/10.1111/sjoe.12514 SN - 0347-0520 SN - 1467-9442 N1 - The authors thank Anders Forslund, Markus Gehrsitz, Aderonke Osikominu, Ulrika Vikman, two anonymous reviewers, and participants at conferences and workshops in Lyon, Nuremberg, Bath, Leipzig, and Basel, and at seminars in Copenhagen, Potsdam, Hamburg, and Uppsala for valuable comments. M. Caliendo gratefully acknowledges funding from the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG, 405629508). J. Vikström acknowledges support from FORTE (2015-00971). VL - 125 IS - 2 SP - 339 EP - 375 PB - Wiley-Blackwell CY - Oxford ER - TY - RPRT A1 - Caliendo, Marco A1 - Mahlstedt, Robert A1 - van den Berg, Gerard J. A1 - Vikström, Johan T1 - Side Effects of Labor Market Policies T2 - CEPA Discussion Papers N2 - Labor market policy tools such as training and sanctions are commonly used to help bring workers back to work. By analogy to medical treatments, the individual exposure to these tools may have side effects. We study effects on health using individual-level population registers on labor market events outcomes, drug prescriptions and sickness absence, comparing outcomes before and after exposure to training and sanctions. We find that training improves cardiovascular and mental health and lowers sickness absence. The results suggest that this is not due to improved employment prospects but rather to instantaneous features of participation such as, perhaps, the adoption of a more rigorous daily routine. Unemployment benefits sanctions cause a short-run deterioration of mental health, possibly due higher stress levels, but this tapers out quickly. T3 - CEPA Discussion Papers - 22 KW - unemployment KW - health KW - sickness KW - prescriptions KW - mental health KW - drugs KW - training KW - depression KW - cardiovascular disease KW - sanctions Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-478839 SN - 2628-653X IS - 22 ER - TY - GEN A1 - Bald, Ilko A1 - Kopyra, Janina A1 - Keller, Adrian T1 - On the role of fluoro-substituted nucleosides in DNA radiosensitization for tumor radiation therapy N2 - Gemcitabine (2′,2′-difluorocytidine) is a well-known radiosensitizer routinely applied in concomitant chemoradiotherapy. During irradiation of biological media with high-energy radiation secondary low-energy (<10 eV) electrons are produced that can directly induce chemical bond breakage in DNA by dissociative electron attachment (DEA). Here, we investigate and compare DEA to the three molecules 2′-deoxycytidine, 2′-deoxy-5-fluorocytidine, and gemcitabine. Fluorination at specific molecular sites, i.e., nucleobase or sugar moiety, is found to control electron attachment and subsequent dissociation pathways. The presence of two fluorine atoms at the sugar ring results in more efficient electron attachment to the sugar moiety and subsequent bond cleavage. For the formation of the dehydrogenated nucleobase anion, we obtain an enhancement factor of 2.8 upon fluorination of the sugar, whereas the enhancement factor is 5.5 when the nucleobase is fluorinated. The observed fragmentation reactions suggest enhanced DNA strand breakage induced by secondary electrons when gemcitabine is incorporated into DNA. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 167 KW - low-energy electrons KW - single-strand breaks KW - gas-phase KW - chemoradiation therapy KW - molecular-mechanisms KW - resonant formation KW - damage KW - attachment KW - drugs Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-73412 SP - 6825 EP - 6829 ER - TY - JOUR A1 - Bald, Ilko A1 - Keller, Adrian A1 - Kopyra, Janina T1 - On the role of fluoro-substituted nucleosides in DNA radiosensitization for tumor radiation therapy JF - RSC Advances : an international journal to further the chemical sciences N2 - Gemcitabine (2′,2′-difluorocytidine) is a well-known radiosensitizer routinely applied in concomitant chemoradiotherapy. During irradiation of biological media with high-energy radiation secondary low-energy (<10 eV) electrons are produced that can directly induce chemical bond breakage in DNA by dissociative electron attachment (DEA). Here, we investigate and compare DEA to the three molecules 2′-deoxycytidine, 2′-deoxy-5-fluorocytidine, and gemcitabine. Fluorination at specific molecular sites, i.e., nucleobase or sugar moiety, is found to control electron attachment and subsequent dissociation pathways. The presence of two fluorine atoms at the sugar ring results in more efficient electron attachment to the sugar moiety and subsequent bond cleavage. For the formation of the dehydrogenated nucleobase anion, we obtain an enhancement factor of 2.8 upon fluorination of the sugar, whereas the enhancement factor is 5.5 when the nucleobase is fluorinated. The observed fragmentation reactions suggest enhanced DNA strand breakage induced by secondary electrons when gemcitabine is incorporated into DNA. KW - low-energy electrons KW - single-strand breaks KW - gas-phase KW - chemoradiation therapy KW - molecular-mechanisms KW - resonant formation KW - damage KW - attachment KW - drugs Y1 - 2014 U6 - https://doi.org/10.1039/C3RA46735J SN - 2046-2069 VL - 4 IS - 13 SP - 6825 EP - 6829 PB - Royal Society of Chemistry ER - TY - GEN A1 - Flemes, Daniel T1 - Transnationale Bedrohungen in Lateinamerika : Instrumente und Kooperationsebenen der Kriminalitäts- und Terrorismusbekämpfung T1 - Transnational threats : drugs and terrorism in Latin America N2 - Organized drug trafficking and transnationally networked terrorism are transnational threats in Latin America. Security experts see the first as the paramount problem, but regard the second as a mere potential security risk. Latin America’s specific conditions allow limited options for containing non-military threats. Should actors and instruments for containing crime and terrorism be organized on a subregional level, in the Latin American or in the Inter-American context? The author documents promising subregional approaches, especially in the extended Mercosur. KW - Lateinamerika KW - Militär KW - subregionale Kooperation KW - Drogen KW - Terrorismus KW - Latin America KW - military KW - subregional cooperation KW - drugs KW - terrorism Y1 - 2005 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-48261 ER -