TY  - GEN
A1  - Wuertz-Kozak, Karin
A1  - Roszkowski, Martin
A1  - Cambria, Elena
A1  - Block, Andrea
A1  - Kuhn, Gisela A.
A1  - Abele, Thea
A1  - Hitzl, Wolfgang
A1  - Drießlein, David
A1  - Müller, Ralph
A1  - Rapp, Michael Armin
A1  - Mansuy, Isabelle M.
A1  - Peters, Eva M. J.
A1  - Wippert, Pia-Maria
T1  - Effects of Early Life Stress on Bone Homeostasis in Mice and Humans
T2  - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
N2  - Bone pathology is frequent in stressed individuals. A comprehensive examination of mechanisms linking life stress, depression and disturbed bone homeostasis is missing. In this translational study, mice exposed to early life stress (MSUS) were examined for bone microarchitecture (μCT), metabolism (qPCR/ELISA), and neuronal stress mediator expression (qPCR) and compared with a sample of depressive patients with or without early life stress by analyzing bone mineral density (BMD) (DXA) and metabolic changes in serum (osteocalcin, PINP, CTX-I). MSUS mice showed a significant decrease in NGF, NPYR1, VIPR1 and TACR1 expression, higher innervation density in bone, and increased serum levels of CTX-I, suggesting a milieu in favor of catabolic bone turnover. MSUS mice had a significantly lower body weight compared to control mice, and this caused minor effects on bone microarchitecture. Depressive patients with experiences of childhood neglect also showed a catabolic pattern. A significant reduction in BMD was observed in depressive patients with childhood abuse and stressful life events during childhood. Therefore, future studies on prevention and treatment strategies for both mental and bone disease should consider early life stress as a risk factor for bone pathologies.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 670 
KW  - psychosocial stress
KW  - bone pathologies
KW  - osteoporosis
KW  - bone mineral density
KW  - childhood
KW  - neuroendocrine
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-485324
SN  - 1866-8364
IS  - 670
ER  - 
TY  - JOUR
A1  - Wuertz-Kozak, Karin
A1  - Roszkowski, Martin
A1  - Cambria, Elena
A1  - Block, Andrea
A1  - Kuhn, Gisela A.
A1  - Abele, Thea
A1  - Hitzl, Wolfgang
A1  - Drießlein, David
A1  - Müller, Ralph
A1  - Rapp, Michael Armin
A1  - Mansuy, Isabelle M.
A1  - Peters, Eva M. J.
A1  - Wippert, Pia-Maria
T1  - Effects of Early Life Stress on Bone Homeostasis in Mice and Humans
JF  - International Journal of Molecular Sciences
N2  - Bone pathology is frequent in stressed individuals. A comprehensive examination of mechanisms linking life stress, depression and disturbed bone homeostasis is missing. In this translational study, mice exposed to early life stress (MSUS) were examined for bone microarchitecture (μCT), metabolism (qPCR/ELISA), and neuronal stress mediator expression (qPCR) and compared with a sample of depressive patients with or without early life stress by analyzing bone mineral density (BMD) (DXA) and metabolic changes in serum (osteocalcin, PINP, CTX-I). MSUS mice showed a significant decrease in NGF, NPYR1, VIPR1 and TACR1 expression, higher innervation density in bone, and increased serum levels of CTX-I, suggesting a milieu in favor of catabolic bone turnover. MSUS mice had a significantly lower body weight compared to control mice, and this caused minor effects on bone microarchitecture. Depressive patients with experiences of childhood neglect also showed a catabolic pattern. A significant reduction in BMD was observed in depressive patients with childhood abuse and stressful life events during childhood. Therefore, future studies on prevention and treatment strategies for both mental and bone disease should consider early life stress as a risk factor for bone pathologies.
KW  - psychosocial stress
KW  - bone pathologies
KW  - osteoporosis
KW  - bone mineral density
KW  - childhood
KW  - neuroendocrine
Y1  - 2020
U6  - https://doi.org/10.3390/ijms21186634
SN  - 1422-0067
VL  - 21
IS  - 18
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -