TY - JOUR A1 - Zühlke, Martin A1 - Zenichowski, Karl A1 - Riebe, Daniel A1 - Beitz, Toralf A1 - Löhmannsröben, Hans-Gerd T1 - Subambient pressure electrospray ionization ion mobility spectrometry JF - International journal for ion mobility spectrometry : official publication of the International Society for Ion Mobility Spectrometry N2 - The pressure dependence of sheath gas assisted electrospray ionization (ESI) was investigated based on two complementary experimental setups, namely an ESI-ion mobility (IM) spectrometer and an ESI capillary - Faraday plate setup housed in an optically accessible vacuum chamber. The ESI-IM spectrometer is capable of working in the pressure range between 300 and 1000 mbar. Another aim was the assessment of the analytical capabilities of a subambient pressure ESI-IM spectrometer. The pressure dependence of ESI was characterized by imaging the electrospray and recording current-voltage (I-U) curves. Qualitatively different behavior was observed in both setups. While the current rises continuously with the voltage in the capillary-plate setup, a sharp increase of the current was measured in the IM spectrometer above a pressure-dependent threshold voltage. The different character can be attributed to the detection of different species in both experiments. In the capillary-plate experiment, a multitude of charged species are detected while only desolvated ions attribute to the IM spectrometer signal. This finding demonstrates the utility of IM spectrometry for the characterization of ESI, since in contrast to the capillary-plate setup, the release of ions from the electrospray droplets can be observed. The I-U curves change significantly with pressure. An important result is the reduction of the maximum current with decreasing pressure. The connected loss of ionization efficiency can be compensated by a more efficient transfer of ions in the IM spectrometer at increased E/N. Thus, similar limits of detection could be obtained at 500 mbar and 1 bar. KW - Ion mobility spectrometry KW - Electrospray ionization KW - Subambient pressure KW - Imaging Y1 - 2017 U6 - https://doi.org/10.1007/s12127-017-0215-x SN - 1435-6163 SN - 1865-4584 VL - 20 SP - 47 EP - 56 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Zühlke, Martin A1 - Sass, Stephan A1 - Riebe, Daniel A1 - Beitz, Toralf A1 - Löhmannsröben, Hans-Gerd T1 - Real-Time Reaction Monitoring of an Organic Multistep Reaction by Electrospray Ionization-Ion Mobility Spectrometry JF - ChemPlusChem N2 - The capability of electrospray ionization (ESI)-ion mobility (IM) spectrometry for reaction monitoring is assessed both as a stand-alone real-time technique and in combination with HPLC. A three-step chemical reaction, consisting of a Williamson ether synthesis followed by a hydrogenation and an N-alkylation step, is chosen for demonstration. Intermediates and products are determined with a drift time to mass-per-charge correlation. Addition of an HPLC column to the setup increases the separation power and allows the determination of further species. Monitoring of the intensities of the various species over the reaction time allows the detection of the end of reaction, determination of the rate-limiting step, observation of the system response in discontinuous processes, and optimization of the mass ratios of the starting materials. However, charge competition in ESI influences the quantitative detection of substances in the reaction mixture. Therefore, two different methods are investigated, which allow the quantification and investigation of reaction kinetics. The first method is based on the pre-separation of the compounds on an HPLC column and their subsequent individual detection in the ESI-IM spectrometer. The second method involves an extended calibration procedure, which considers charge competition effects and facilitates nearly real-time quantification. KW - electrospray ionization KW - HPLC KW - ion mobility spectrometry KW - reaction mechanisms KW - reaction monitoring Y1 - 2017 U6 - https://doi.org/10.1002/cplu.201700296 SN - 2192-6506 VL - 82 SP - 1266 EP - 1273 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Zöller, Gert A1 - Ullah, Shahid A1 - Bindi, Dino A1 - Parolai, Stefano A1 - Mikhailova, Natalya T1 - The largest expected earthquake magnitudes in Central Asia BT - statistical inference from an earthquake catalogue with uncertain magnitudes JF - Seismicity, fault rupture and earthquake hazards in slowly deforming regions N2 - The knowledge of the largest expected earthquake magnitude in a region is one of the key issues in probabilistic seismic hazard calculations and the estimation of worst-case scenarios. Earthquake catalogues are the most informative source of information for the inference of earthquake magnitudes. We analysed the earthquake catalogue for Central Asia with respect to the largest expected magnitudes m(T) in a pre-defined time horizon T-f using a recently developed statistical methodology, extended by the explicit probabilistic consideration of magnitude errors. For this aim, we assumed broad error distributions for historical events, whereas the magnitudes of recently recorded instrumental earthquakes had smaller errors. The results indicate high probabilities for the occurrence of large events (M >= 8), even in short time intervals of a few decades. The expected magnitudes relative to the assumed maximum possible magnitude are generally higher for intermediate-depth earthquakes (51-300 km) than for shallow events (0-50 km). For long future time horizons, for example, a few hundred years, earthquakes with M >= 8.5 have to be taken into account, although, apart from the 1889 Chilik earthquake, it is probable that no such event occurred during the observation period of the catalogue. Y1 - 2017 SN - 978-1-86239-745-3 SN - 978-1-86239-964-8 U6 - https://doi.org/10.1144/SP432.3 SN - 0305-8719 VL - 432 SP - 29 EP - 40 PB - The Geological Society CY - London ER - TY - JOUR A1 - Zuba, Anna A1 - Warschburger, Petra T1 - The role of weight teasing and weight bias internalization in psychological functioning: a prospective study among school-aged children JF - European child and adolescent psychiatry : offical journal of the European Society for Child and Adolescent Psychiatry N2 - Weight-related teasing is a widespread phenomenon in childhood, and might foster the internalization of weight bias. The goal of this study was to examine the role of weight teasing and weight bias internalization as mediators between weight status and negative psychological sequelae, such as restrained eating and emotional and conduct problems in childhood. Participants included 546 female (52%) and 501 (48%) male children aged 7-11 and their parents, who completed surveys assessing weight teasing, weight bias internalization, restrained eating behaviors, and emotional and conduct problems at two points of measurement, approximately 2 years apart. To examine the hypothesized mediation, a prospective design using structural equation modeling was applied. As expected, the experience of weight teasing and the internalization of weight bias were mediators in the relationship between weight status and psychosocial problems. This pattern was observed independently of gender or weight status. Our findings suggest that the experience of weight teasing and internalization of weight bias is more important than weight status in explaining psychological functioning among children and indicate a need for appropriate prevention and intervention approaches. KW - Weight teasing KW - Weight bias internalization KW - Psychological functioning KW - Childhood KW - Prospective study Y1 - 2017 U6 - https://doi.org/10.1007/s00787-017-0982-2 SN - 1018-8827 SN - 1435-165X VL - 26 SP - 1245 EP - 1255 PB - Springer CY - New York ER - TY - JOUR A1 - Zou, Jie A1 - Wang, Weiwei A1 - Neffe, Axel T. A1 - Xu, Xun A1 - Li, Zhengdong A1 - Deng, Zijun A1 - Sun, Xianlei A1 - Ma, Nan A1 - Lendlein, Andreas T1 - Adipogenic differentiation of human adipose derived mesenchymal stem cells in 3D architectured gelatin based hydrogels (ArcGel) JF - Clinical hemorheology and microcirculation : blood flow and vessels N2 - Polymeric matrices mimicking multiple functions of the ECM are expected to enable a material induced regeneration of tissues. Here, we investigated the adipogenic differentiation of human adipose derived mesenchymal stem cells (hADSCs) in a 3D architectured gelatin based hydrogel (ArcGel) prepared from gelatin and L-lysine diisocyanate ethyl ester (LDI) in an one-step process, in which the formation of an open porous morphology and the chemical network formation were integrated. The ArcGel was designed to support adipose tissue regeneration with its 3D porous structure, high cell biocompatibility, and mechanical properties compatible with human subcutaneous adipose tissue. The ArcGel could support initial cell adhesion and survival of hADSCs. Under static culture condition, the cells could migrate into the inner part of the scaffold with a depth of 840 +/- 120 mu m after 4 days, and distributed in the whole scaffold (2mm in thickness) within 14 days. The cells proliferated in the scaffold and the fold increase of cell number after 7 days of culture was 2.55 +/- 0.08. The apoptotic rate of hADSCs in the scaffold was similar to that of cells maintained on tissue culture plates. When cultured in adipogenic induction medium, the hADSCs in the scaffold differentiated into adipocytes with a high efficiency (93 +/- 1%). Conclusively, this gelatin based 3D scaffold presented high cell compatibility for hADSC cultivation and differentiation, which could serve as a potential implant material in clinical applications for adipose tissue reparation and regeneration. KW - Mesenchymal stem cells KW - gelatin based scaffold KW - adipose tissue regeneration KW - adipogenic differentiation Y1 - 2017 U6 - https://doi.org/10.3233/CH-179210 SN - 1386-0291 SN - 1875-8622 VL - 67 IS - 3-4 SP - 297 EP - 307 PB - IOS Press CY - Amsterdam ER - TY - JOUR A1 - Zohsel, Katrin A1 - Holz, Nathalie E. A1 - Hohm, Erika A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Brandeis, Daniel A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Fewer self-reported depressive symptoms in young adults exposed to maternal depressed mood during pregnancy JF - Journal of Affective Disorders N2 - Background: Depressed mood is prevalent during pregnancy, with accumulating evidence suggesting an impact on developmental outcome in the offspring. However, the long-term effects of prenatal maternal depression regarding internalizing psychopathology in the offspring are as yet unclear. Results: In n=85 young adults exposed to prenatal maternal depressed mood, no significantly higher risk for a diagnosis of depressive disorder was observed. However, they reported significantly lower levels of depressive symptoms. This association was especially pronounced when prenatal maternal depressed mood was present during the first trimester of pregnancy and when maternal mood was depressed pre- as well as postnatally. At an uncorrected level only, prenatal maternal depressed mood was associated with decreased amygdala volume. Limitations: Prenatal maternal depressed mood was not assessed during pregnancy, but shortly after childbirth. No diagnoses of maternal clinical depression during pregnancy were available. Conclusions: Self-reported depressive symptoms do not imply increased, but rather decreased symptom levels in young adults who were exposed to prenatal maternal depressed mood. A long-term perspective may be important when considering consequences of prenatal risk factors. Y1 - 2016 U6 - https://doi.org/10.1016/j.jad.2016.08.059 SN - 0165-0327 SN - 1573-2517 VL - 209 SP - 155 EP - 162 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Zohsel, Katrin A1 - Hohm, Erika A1 - Schmidt, Martin H. A1 - Brandeis, Daniel A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Die langfristigen Auswirkungen von Frühgeburtlichkeit auf kognitive Entwicklung und Schulerfolg T1 - Long-term consequences of preterm birth on cognitive development and academic achievement BT - Gibt es einen protektiven Effekt mütterlicher Responsivität? BT - Is there a protective effect of maternal responsiveness? JF - Kindheit und Entwicklung N2 - In einer prospektiven Längsschnittstudie wurde der Zusammenhang zwischen früher Responsivität der Mutter und kognitiver Entwicklung ihrer früh- bzw. reifgeborenen Kinder untersucht. Im Alter von drei Monaten wurde dafür die Mutter-Kind-Interaktion mittels Verhaltensbeobachtung erfasst. Bei n=351 der teilnehmenden Kinder (101 frühgeboren) wurde die allgemeine Intelligenz (IQ) im Alter von 11 Jahren und bei n=313 (85 frühgeboren) zusätzlich der höchste erreichte Schulabschluss bis 25 Jahren erhoben. Frühgeborene wiesen mit 11 Jahren einen signifikant niedrigeren IQ als Reifgeborene auf, nachdem für mögliche konfundierende Faktoren kontrolliert worden war. Nur bei Früh-, nicht aber bei Reifgeborenen zeigte sich ein signifikanter positiver Zusammenhang zwischen mütterlicher Responsivität und IQ. Für die Wahrscheinlichkeit einen höheren Schulabschluss (mind. Fachabitur) zu erreichen, fand sich weder ein signifikanter Effekt von Frühgeburtlichkeit noch von mütterlicher Responsivität. N2 - Preterm birth is associated with adverse long-term consequences regarding cognitive development. Whereas children born very preterm represent a subgroup at special risk, so-called late preterms are also affected to a lesser degree. Effects of prematurity can be observed until adulthood. For example, decreased wealth was reported in adults born preterm, which was mediated by decreased intelligence during childhood and lower educational qualifications during young adulthood. Hence, it is highly relevant to examine whether certain factors can buffer against the adverse effects of preterm birth on cognitive development. Parenting might play an important role here. There is evidence suggesting a protective effect of sensitive parenting during childhood on later cognitive outcome in preterms. In the current study, we examined whether early responsive maternal care was associated with later intelligence and academic achievement in children born preterm versus full term. As part of an ongoing cohort study, early maternal responsiveness was assessed at the child’s age of 3 months (adjusted for gestational age) during a nursing and playing situation. At age 11 years, general intelligence (IQ) was determined in n = 351 children (101 born preterm; 168 male). Until age 25 years, educational qualification was assessed in n = 313 participants (85 born preterm; 145 male). IQ at age 11 was significantly lower in preterms compared with full-term subjects after adjusting for potential confounders like maternal educational background and early psychosocial risk. A significant interaction between preterm birth and early maternal responsiveness was detected. In preterms only, higher levels of early maternal responsiveness were significantly associated with higher child IQ. Lower IQs in children born preterm as compared with those born full term were observed in the subaverage-to-average range of maternal responsiveness. Interestingly, preterms exposed to very high levels of maternal responsiveness showed slightly higher IQs when compared with children born at term. With regard to academic achievement, neither a significant effect of preterm birth nor of early maternal responsiveness occurred after adjusting for potential confounders. The results of the current study replicate and extend earlier findings with regard to a protective effect of sensitive parenting on childhood cognitive outcome in preterms. The lacking impact of prematurity on academic achievement may be explained by the exclusion of participants with IQs outside the normal range in the current study. Interventions enhancing early responsive care in parents of preterms may be advisable. More studies on long-term outcomes of such interventions on cognitive development are encouraged. KW - preterm birth KW - parental quality KW - cognitive development KW - longitudinal study KW - Mannheim Study of Children at Risk KW - Frühgeburt KW - Elternverhalten KW - kognitive Entwicklung KW - Längsschnittstudie KW - Mannheimer Risikokinderstudie Y1 - 2017 U6 - https://doi.org/10.1026/0942-5403/a000235 SN - 0942-5403 SN - 2190-6246 VL - 26 SP - 221 EP - 229 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Zohsel, Katrin A1 - Hohm, Erika A1 - Schmidt, Martin H. A1 - Brandeis, Daniel A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Long-Term Consequences of Early Psychosocial Risks T1 - Langfristige Folgen früher psychosozialer Risiken BT - Mediating Role of the Child Behavior Checklist-Dysregulation Profile BT - Child Behavior Checklist-Dysregulationsprofil als vermittelnder Faktor JF - Kindheit und Entwicklung N2 - In einer prospektiven Längsschnittstudie wurden Auswirkungen früher psychosozialer Risiken bis ins junge Erwachsenenalter untersucht und dabei die Rolle von affektiver und behavioraler Dysregulation im Kindesalter als vermittelndem Faktor überprüft. Drei Monate nach der Geburt wurde das Vorliegen von 11 psychosozialen Belastungsfaktoren erfasst. Im Alter von 8 – 15 Jahren wurde dreimal das Child Behavior Checklist-Dysregulationsprofil (CBCL-DP) erhoben. Mit 25 Jahren wurde ein Strukturiertes Klinisches Interview durchgeführt und 309 der Teilnehmer füllten den Young Adult Self-Report aus. Frühe psychosoziale Risiken gingen mit einem erhöhten Risiko für das Vorliegen eines Substanzmissbrauchs im jungen Erwachsenenalter sowie mit erhöhtem externalisierendem und internalisierendem Problemverhalten einher. Der Zusammenhang zwischen frühen psychosozialen Risiken und späterem externalisierendem bzw. internalisierendem Problemverhalten wurde durch das CBCL-DP vermittelt. N2 - Numerous studies suggested an association between childhood adversities and later increased risk for mental illness. However, most studies have used adults’ retrospective self-reports for assessing adverse childhood experiences. Mechanisms underlying the association between childhood adversities and later psychopathology are not yet well understood. In the Mannheim Study of Children at Risk, we prospectively examined the impact of early psychosocial risks on psychopathology in early adulthood. In addition, we tested the mediating role of childhood affective and behavioral dysregulation. In a total of 384 infants from the Rhine-Neckar region of Germany born between 1986 and 1988, the presence of 11 adverse family factors was assessed by use of a standardized parent interview conducted when the child was 3 months old. At the child’s age of 8, 11, and 15 years, parents completed the Child Behavior Checklist (CBCL). The CBCL-Dysregulation Profile (CBCL-DP) was formed by summing up the scores of the syndrome scales of aggressive, inattentive, and anxious/depressed behavior. At the age of 25 years, the Structured Clinical Interview for DSM-IV (SCID) was conducted with n = 307 participants to obtain psychiatric diagnoses for the period of young adulthood. In addition, 309 participants filled out the Young Adult Self-Report (YASR) to assess current externalizing and internalizing problem behavior. With respect to psychiatric diagnoses during young adulthood, early psychosocial risks were associated with a significantly increased probability for suffering from substance abuse/dependence. By contrast, risk was not significantly increased for anxiety, depressive, and personality disorders. In addition, early psychosocial risks significantly predicted externalizing and internalizing behavior problems as measured by the YASR. The CBCL-DP was found to mediate this association. To conclude, our results confirm an association between childhood adversities and psychopathology in adulthood. Hence, findings from retrospective studies can also be replicated by the use of prospective study designs. Affective and behavioral dysregulation as measured by the CBCL-DP seems to be a mediating bridge between early psychosocial risks and long-term adverse consequences. The CBCL-DP may be used to identify children at an enhanced risk for developing chronic mental problems. KW - early adversity KW - longitudinal study KW - Mannheim Study of Children at Risk KW - Child Behavior Checklist-Dysregulation Profile Y1 - 2017 U6 - https://doi.org/10.1026/0942-5403/a000233 SN - 0942-5403 SN - 2190-6246 VL - 26 IS - 4 SP - 203 EP - 209 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Zimmermann, Heike Hildegard A1 - Raschke, Elena A1 - Epp, Laura Saskia A1 - Stoof-Leichsenring, Kathleen Rosemarie A1 - Schwamborn, Georg A1 - Schirrmeister, Lutz A1 - Overduin, Pier Paul A1 - Herzschuh, Ulrike T1 - Sedimentary ancient DNA and pollen reveal the composition of plant organic matter in Late Quaternary permafrost sediments of the Buor Khaya Peninsula (north-eastern Siberia) JF - Biogeosciences N2 - Organic matter deposited in ancient, ice-rich permafrost sediments is vulnerable to climate change and may contribute to the future release of greenhouse gases; it is thus important to get a better characterization of the plant organic matter within such sediments. From a Late Quaternary permafrost sediment core from the Buor Khaya Peninsula, we analysed plant-derived sedimentary ancient DNA (sedaDNA) to identify the taxonomic composition of plant organic matter, and undertook palynological analysis to assess the environmental conditions during deposition. Using sedaDNA, we identified 154 taxa and from pollen and non-pollen palynomorphs we identified 83 taxa. In the deposits dated between 54 and 51 kyr BP, sedaDNA records a diverse low-centred polygon plant community including recurring aquatic pond vegetation while from the pollen record we infer terrestrial open-land vegetation with relatively dry environmental conditions at a regional scale. A fluctuating dominance of either terrestrial or swamp and aquatic taxa in both proxies allowed the local hydrological development of the polygon to be traced. In deposits dated between 11.4 and 9.7 kyr BP (13.4-11.1 cal kyr BP), sedaDNA shows a taxonomic turnover to moist shrub tundra and a lower taxonomic richness compared to the older samples. Pollen also records a shrub tundra community, mostly seen as changes in relative proportions of the most dominant taxa, while a decrease in taxonomic richness was less pronounced compared to sedaDNA. Our results show the advantages of using sedaDNA in combination with palynological analyses when macrofossils are rarely preserved. The high resolution of the sedaDNA record provides a detailed picture of the taxonomic composition of plant-derived organic matter throughout the core, and palynological analyses prove valuable by allowing for inferences of regional environmental conditions. Y1 - 2017 U6 - https://doi.org/10.5194/bg-14-575-2017 SN - 1726-4170 SN - 1726-4189 VL - 14 IS - 3 SP - 575 EP - 596 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Zimmermann, Heike Hildegard A1 - Raschke, Elena A1 - Epp, Laura Saskia A1 - Stoof-Leichsenring, Kathleen Rosemarie A1 - Schirrmeister, Lutz A1 - Schwamborn, Georg A1 - Herzschuh, Ulrike T1 - The history of tree and shrub taxa on Bol'shoy Lyakhovsky Island (New Siberian Archipelago) since the Last Interglacial Uncovered by Sedimentary Ancient DNA and Pollen Data JF - Genes N2 - Ecosystem boundaries, such as the Arctic-Boreal treeline, are strongly coupled with climate and were spatially highly dynamic during past glacial-interglacial cycles. Only a few studies cover vegetation changes since the last interglacial, as most of the former landscapes are inundated and difficult to access. Using pollen analysis and sedimentary ancient DNA (sedaDNA) metabarcoding, we reveal vegetation changes on Bol’shoy Lyakhovsky Island since the last interglacial from permafrost sediments. Last interglacial samples depict high levels of floral diversity with the presence of trees (Larix, Picea, Populus) and shrubs (Alnus, Betula, Ribes, Cornus, Saliceae) on the currently treeless island. After the Last Glacial Maximum, Larix re-colonised the island but disappeared along with most shrub taxa. This was probably caused by Holocene sea-level rise, which led to increased oceanic conditions on the island. Additionally, we applied two newly developed larch-specific chloroplast markers to evaluate their potential for tracking past population dynamics from environmental samples. The novel markers were successfully re-sequenced and exhibited two variants of each marker in last interglacial samples. SedaDNA can track vegetation changes as well as genetic changes across geographic space through time and can improve our understanding of past processes that shape modern patterns. KW - sedaDNA KW - metabarcoding KW - trnL KW - single-nucleotide polymorphism (SNP) KW - treeline KW - MIS 5 to 1 KW - permafrost deposits KW - radiocarbon ages KW - palaeoenvironment KW - Larix Y1 - 2017 U6 - https://doi.org/10.3390/genes8100273 SN - 2073-4425 VL - 8 IS - 10 SP - 273 PB - MDPI CY - Basel ER - TY - JOUR A1 - Zimmermann, Andreas T1 - Humanitarian Assistance and the Security Council JF - Israel Law Review N2 - Over the years, the Security Council has on several occasions dealt with humanitarian assistance issues. However, it is Security Council Resolution 2165(2014), related to the situation in Syria, that has brought the role of the Security Council to the forefront of the debate. It is against this background that the article discusses the legal issues arising from Security Council action facilitating humanitarian assistance to be delivered in situations of non-international armed conflict. Following a brief survey of relevant practice of the Security Council related to humanitarian assistance, the article considers the relevance, if any, of Article 2(7) of the Charter of the United Nations (UN) to humanitarian assistance to be delivered in such situations. It then moves on to analyse whether a rejection by the territorial state of humanitarian aid to be delivered by third parties may amount to a situation under Article 39 of the UN Charter. It then considers in detail whether (at least implicitly) Resolution 2165 has been adopted under Chapter VII and, if this is not the case, whether it can be still considered to be legally binding. The article finally considers what impact the adoption of Security Council Resolution 2165 might have on the interpretation of otherwise applicable rules of international humanitarian law and, in particular, the right of third parties to provide humanitarian assistance in a situation of a non-international armed conflict in spite of the absence of consent by the territorial state, and the obligations that members of the Security Council, permanent and non-permanent, have under Common Article 1 of the Geneva Conventions when faced with a draft resolution providing for the delivery of humanitarian assistance, notwithstanding the absence of consent by the territorial state. Y1 - 2017 SN - 0021-2237 U6 - https://doi.org/doi.org/10.1017/S0021223716000315 VL - 50 IS - 1 SP - 3 EP - 23 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Ziegler, Moritz O. A1 - Heidbach, Oliver A1 - Zang, Arno A1 - Martinez-Garzon, Patricia A1 - Bohnhoff, Marco T1 - Estimation of the differential stress from the stress rotation angle in low permeable rock JF - Geophysical research letters N2 - Rotations of the principal stress axes are observed as a result of fluid injection into reservoirs. We use a generic, fully coupled 3-D thermo-hydro-mechanical model to investigate systematically the dependence of this stress rotation on different reservoir properties and injection scenarios. We find that permeability, injection rate, and initial differential stress are the key factors, while other reservoir properties only play a negligible role. In particular, we find that thermal effects do not significantly contribute to stress rotations. For reservoir types with usual differential stress and reservoir treatment the occurrence of significant stress rotations is limited to reservoirs with a permeability of less than approximately 10(-12)m(2). Higher permeability effectively prevents stress rotations to occur. Thus, according to these general findings, the observed principal stress axes rotation can be used as a proxy of the initial differential stress provided that rock permeability and fluid injection rate are known a priori. Y1 - 2017 U6 - https://doi.org/10.1002/2017GL073598 SN - 0094-8276 SN - 1944-8007 VL - 44 SP - 6761 EP - 6770 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Zibulski, Romy A1 - Wesener, Felix A1 - Wilkes, Heinz A1 - Plessen, Birgit A1 - Pestryakova, Luidmila Agafyevna A1 - Herzschuh, Ulrike T1 - C / N ratio, stable isotope (delta C-13, delta N-15), and n-alkane patterns of brown mosses along hydrological gradients of low-centred polygons of the Siberian Arctic JF - Biogeosciences N2 - Mosses are a major component of the arctic vegetation, particularly in wetlands. We present C / N atomic ratio, delta C-13 and delta N-15 data of 400 brown-moss samples belonging to 10 species that were collected along hydrological gradients within polygonal mires located on the southern Taymyr Peninsula and the Lena River delta in northern Siberia. Additionally, n-alkane patterns of six of these species (16 samples) were investigated. The aim of the study is to see whether the inter-and intraspecific differences in C / N, isotopic compositions and n-alkanes are indicative of habitat, particularly with respect to water level. Overall, we find high variability in all investigated parameters for two different moisture-related groups of moss species. The C / N ratios range between 11 and 53 (median: 32) and show large variations at the intraspecific level. However, species preferring a dry habitat (xero-mesophilic mosses) show higher C / N ratios than those preferring a wet habitat (meso-hygrophilic mosses). The delta C-13 values range between 37.0 and 22.5% (median D 27.8 %). The delta N-15 values range between 6.6 and C 1.7%(median D 2.2 %). We find differences in delta C-13 and delta N-15 compositions between both habitat types. For some species of the meso-hygrophilic group, we suggest that a relationship between the individ-ual habitat water level and isotopic composition can be inferred as a function of microbial symbiosis. The n-alkane distribution also shows differences primarily between xeromesophilic and meso-hygrophilic mosses, i. e. having a dominance of n-alkanes with long (n-C29, n-C31 /and intermediate (n-C25 /chain lengths, respectively. Overall, our results reveal that C / N ratios, isotopic signals and n-alkanes of studied brown-moss taxa from polygonal wetlands are characteristic of their habitat. Y1 - 2017 U6 - https://doi.org/10.5194/bg-14-1617-2017 SN - 1726-4170 SN - 1726-4189 VL - 14 SP - 1617 EP - 1630 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Zhu, Jinshan T1 - Assessing China’s price review policy on Clean Development Mechanism projects JF - European Journal of Law and Economics N2 - The Kyoto Protocol’s Clean Development Mechanism (CDM) allows developed countries to meet part of their obligational emission reductions by carrying out emission reduction projects in developing countries. China imposed a price floor to the CDM carbon credits produced in China through its price review policy. Scholars have not agreed on the purpose of China’s price review policy. With a theoretical model and a coherent empirical study, the present study shows that the price floor imposed by China’s price review is more likely to protect those domestic project owners against price discrimination, rather than to distort the CDM market. Nevertheless, China’s price review has its own flaws. Although a regression study shows month of approval, types of projects and location of project can explain 55% of price floor designation, the operation of price review remains quite random and unpredictable in individual cases. This would bring extra bureaucratically uncertainty on its way to curb market uncertainty. Its function can be fulfilled by alternative policy tools with better economic efficiency and legal legitimacy, such as mandatory price disclosure and trading forum, which doesn’t have such drawback, but still be able to alleviate possible price discrimination in individual cases. KW - CDM KW - China KW - Price review KW - Price floor KW - Law and economics Y1 - 2017 U6 - https://doi.org/10.1007/s10657-016-9550-3 SN - 0929-1261 SN - 1572-9990 VL - 43 SP - 285 EP - 316 PB - Springer CY - New York ER - TY - JOUR A1 - Zhu, Fangjun A1 - Schlupp, Ingo A1 - Tiedemann, Ralph T1 - Allele-specific expression at the androgen receptor alpha gene in a hybrid unisexual fish, the Amazon molly (Poecilia formosa) JF - PLoS one N2 - The all-female Amazon molly (Poecilia formosa) is the result of a hybridization of the Atlantic molly (P. mexicana) and the sailfin molly (P. latipinna) approximately 120,000 years ago. As a gynogenetic species, P. formosa needs to copulate with heterospecific males including males from one of its bisexual ancestral species. However, the sperm only triggers embryogenesis of the diploid eggs. The genetic information of the sperm donor typically will not contribute to the next generation of P. formosa. Hence, P. formosa possesses generally one allele from each of its ancestral species at any genetic locus. This raises the question whether both ancestral alleles are equally expressed in P. formosa. Allele-specific expression (ASE) has been previously assessed in various organisms, e.g., human and fish, and ASE was found to be important in the context of phenotypic variability and disease. In this study, we utilized Real-Time PCR techniques to estimate ASE of the androgen receptor alpha (arα) gene in several distinct tissues of Amazon mollies. We found an allelic bias favoring the maternal ancestor (P. mexicana) allele in ovarian tissue. This allelic bias was not observed in the gill or the brain tissue. Sequencing of the promoter regions of both alleles revealed an association between an Indel in a known CpG island and differential expression. Future studies may reveal whether our observed cis-regulatory divergence is caused by an ovary-specific trans-regulatory element, preferentially activating the allele of the maternal ancestor. Y1 - 2017 U6 - https://doi.org/10.1371/journal.pone.0186411 SN - 1932-6203 VL - 12 IS - 10 SP - 1 EP - 14 PB - PLoS CY - Lawrence, Kan. ER - TY - JOUR A1 - Zhu, Fangjun A1 - Schlupp, Ingo A1 - Tiedemann, Ralph T1 - Allele-specific expression at the androgen receptor alpha gene in a hybrid unisexual fish, the Amazon molly (Poecilia formosa) JF - PLoS one N2 - The all-female Amazon molly (Poecilia formosa) is the result of a hybridization of the Atlantic molly (P. mexicana) and the sailfin molly (P. latipinna) approximately 120,000 years ago. As a gynogenetic species, P. formosa needs to copulate with heterospecific males including males from one of its bisexual ancestral species. However, the sperm only triggers embryo genesis of the diploid eggs. The genetic information of the sperm donor typically will not contribute to the next generation of P. formosa. Hence, P. formosa possesses generally one allele from each of its ancestral species at any genetic locus. This raises the question whether both ancestral alleles are equally expressed in P. formosa. Allele-specific expression (ASE) has been previously assessed in various organisms, e.g., human and fish, and ASE was found to be important in the context of phenotypic variability and disease. In this study, we utilized Real-Time PCR techniques to estimate ASE of the androgen receptor alpha (ara) gene in several distinct tissues of Amazon mollies. We found an allelic bias favoring the maternal ancestor (P. mexicana) allele in ovarian tissue. This allelic bias was not observed in the gill or the brain tissue. Sequencing of the promoter regions of both alleles revealed an association between an Indel in a known CpG island and differential expression. Future studies may reveal whether our observed cis-regulatory divergence is caused by an ovary-specific trans-regulatory element, preferentially activating the allele of the maternal ancestor. Y1 - 2017 U6 - https://doi.org/10.1371/journal.pone.0186411 SN - 1932-6203 VL - 12 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Zhou, Wei A1 - Shu, Hua A1 - Miller, Kevin A1 - Yan, Ming T1 - Reliance on orthography and phonology in reading of Chinese BT - a developmental study JF - Journal of research in reading : a journal of the United Kingdom Reading Association N2 - BackgroundDisruptions of reading processes due to text substitutions can measure how readers use lexical information. MethodsWith eye-movement recording, children and adults viewed sentences with either identical, orthographically similar, homophonic or unrelated substitutions of the first characters in target words. To the extent that readers rely on orthographic or phonological cues, substitutions that contain such cues should cause less disruption reading than do unrelated substitutions. ResultsOn pretarget words, there was a reliable reduction in gaze duration due to homophonic substitution only for children. On target words, we observed reliable recovery effects due to orthographic similarity for adults. On post-target words, adults had better orthographic-based and phonological-based recovery abilities than children. ConclusionsThe combination of eye movement recording and the error detection paradigm offers a novel implicit paradigm for studying reading development: during sentence reading, beginning readers of Chinese may rely on phonological mediation, while skilled readers have more direct access to semantics from orthography. Y1 - 2017 U6 - https://doi.org/10.1111/1467-9817.12111 SN - 0141-0423 SN - 1467-9817 VL - 41 IS - 2 SP - 370 EP - 391 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Zhou, Bin A1 - Rybski, Diego A1 - Kropp, Jürgen T1 - The role of city size and urban form in the surface urban heat island JF - Scientific reports N2 - Urban climate is determined by a variety of factors, whose knowledge can help to attenuate heat stress in the context of ongoing urbanization and climate change. We study the influence of city size and urban form on the Urban Heat Island (UHI) phenomenon in Europe and find a complex interplay between UHI intensity and city size, fractality, and anisometry. Due to correlations among these urban factors, interactions in the multi-linear regression need to be taken into account. We find that among the largest 5,000 cities, the UHI intensity increases with the logarithm of the city size and with the fractal dimension, but decreases with the logarithm of the anisometry. Typically, the size has the strongest influence, followed by the compactness, and the smallest is the influence of the degree to which the cities stretch. Accordingly, from the point of view of UHI alleviation, small, disperse, and stretched cities are preferable. However, such recommendations need to be balanced against e.g. positive agglomeration effects of large cities. Therefore, trade-offs must be made regarding local and global aims. Y1 - 2017 U6 - https://doi.org/10.1038/s41598-017-04242-2 SN - 2045-2322 VL - 7 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Zhong, Qi A1 - Metwalli, Ezzeldin A1 - Rawolle, Monika A1 - Kaune, Gunar A1 - Bivigou Koumba, Achille Mayelle A1 - Laschewsky, Andre A1 - Papadakis, Christine M. A1 - Cubitt, Robert A1 - Wang, Jiping A1 - Müller-Buschbaum, Peter T1 - Vacuum induced dehydration of swollen poly(methoxy diethylene glycol acrylate) and polystyrene-block-poly(methoxy diethylene glycol acrylate)-block-polystyrene films probed by in-situ neutron reflectivity JF - Polymer : the international journal for the science and technology of polymers N2 - The isothermal vacuum-induced dehydration of thin films made of poly(methoxy diethylene glycol acrylate) (PMDEGA), which were swollen under ambient conditions, is studied. The dehydration behavior of the homopolymer film as well as of a nanostructured film of the amphiphilic triblock copolymer polystyrene-block-poly(methoxy diethylene glycol acrylate)-block-polystyrene, abbreviated as PS-b-PMDEGA-b-PS, are probed, and compared to the thermally induced dehydration behavior of such thin thermo-responsive films when they pass through their LCST-type coil-to globule collapse transition. The dehydration kinetics is followed by in-situ neutron reflectivity measurements. Contrast results from the use of deuterated water. Water content and film thickness are significantly reduced during the process, which can be explained by Schott second order kinetics theory for both films. The water content of the dehydrated equilibrium state from this model is very close to the residual water content obtained from the final static measurements, indicating that residual water still remains in the film even after prolonged exposure to the vacuum. In the PS-b-PMDEGA-b-PS film that shows micro-phase separation, the hydrophobic PS domains modify the dehydration process by hindering the water removal, and thus retarding dehydration by about 30%. Whereas residual water remains tightly bound in the PMDEGA domains, water is completely removed from the PS domains of the block copolymer film. (C) 2017 Elsevier Ltd. All rights reserved. KW - Dehydration KW - Vacuum drying KW - In-situ neutron reflectivity Y1 - 2017 U6 - https://doi.org/10.1016/j.polymer.2017.07.066 SN - 0032-3861 SN - 1873-2291 VL - 124 SP - 263 EP - 273 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Zhilich, Snezhana A1 - Rudaya, Natalia A1 - Krivonogov, Sergei A1 - Nazarova, Larisa B. A1 - Pozdnyakov, Dmitry T1 - Environmental dynamics of the Baraba forest-steppe (Siberia) over the last 8000 years and their impact on the types of economic life of the population JF - Quaternary science reviews : the international multidisciplinary research and review journal N2 - This article offers a reconstruction of the vegetation and climate of the south-western Siberian Baraba forest-steppe area during the last ca. 8000 years. The analysis of palynological data from the sediment core of Lake Bolshie Toroki using quantitative methods has made it possible to reconstruct changes of the dominant types of vegetation and mean July air temperatures. Coniferous forests grew in the vicinity of the lake, and mean July air temperatures were similar to present-day ones between 7.9 and 7.0 kyr BP. The warmest and driest climate occurred at 7.0-5.0 kyr BP. At that time, the region had open steppe landscapes; birch groves began to spread. A cooling trend is seen after 5.5 kyr BP, when forest-steppe began to emerge. Steppe communities started to dominate again after 1.5 kyr BP. Mean July air temperatures lower than now are reconstructed for the period of 1.9-1 kyr BP, and then the temperatures became similar to present-day ones. Comparing the archaeological data on the types of economy of the population which inhabited the Baraba forest-steppe with the data on changes in the natural environment revealed a connection between the gradual transition from hunting and fishing to livestock breeding and the development of forest-steppe landscapes with a decrease in the area covered by forests. The development of the forest-steppe as an ecotonic landscape starting around 5 kyr BP might have contributed to the coexistence of several archaeological cultures with different types of economy on the same territory. (C) 2017 Elsevier Ltd. All rights reserved. KW - Holocene KW - Climate dynamics KW - Russia KW - Vegetation dynamics KW - Baraba forest-steppe KW - Archaeology KW - Transfer function Y1 - 2017 U6 - https://doi.org/10.1016/j.quascirev.2017.03.022 SN - 0277-3791 VL - 163 SP - 152 EP - 161 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Zhelavskaya, Irina A1 - Shprits, Yuri Y. A1 - Spasojevic, Maria T1 - Empirical Modeling of the Plasmasphere Dynamics Using Neural Networks JF - Journal of geophysical research : Space physics N2 - We present the PINE (Plasma density in the Inner magnetosphere Neural network‐based Empirical) model ‐ a new empirical model for reconstructing the global dynamics of the cold plasma density distribution based only on solar wind data and geomagnetic indices. Utilizing the density database obtained using the NURD (Neural‐network‐based Upper hybrid Resonance Determination) algorithm for the period of 1 October 2012 to 1 July 2016, in conjunction with solar wind data and geomagnetic indices, we develop a neural network model that is capable of globally reconstructing the dynamics of the cold plasma density distribution for 2≤L≤6 and all local times. We validate and test the model by measuring its performance on independent data sets withheld from the training set and by comparing the model‐predicted global evolution with global images of He+ distribution in the Earth's plasmasphere from the IMAGE Extreme UltraViolet (EUV) instrument. We identify the parameters that best quantify the plasmasphere dynamics by training and comparing multiple neural networks with different combinations of input parameters (geomagnetic indices, solar wind data, and different durations of their time history). The optimal model is based on the 96 h time history of Kp, AE, SYM‐H, and F10.7 indices. The model successfully reproduces erosion of the plasmasphere on the nightside and plume formation and evolution. We demonstrate results of both local and global plasma density reconstruction. This study illustrates how global dynamics can be reconstructed from local in situ observations by using machine learning techniques. Y1 - 2017 U6 - https://doi.org/10.1002/2017JA024406 SN - 2169-9380 SN - 2169-9402 VL - 122 SP - 11227 EP - 11244 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Zhang, Xiyun A1 - Pikovskij, Arkadij A1 - Liu, Zonghua T1 - Dynamics of oscillators globally coupled via two mean fields JF - Scientific reports N2 - Many studies of synchronization properties of coupled oscillators, based on the classical Kuramoto approach, focus on ensembles coupled via a mean field. Here we introduce a setup of Kuramoto-type phase oscillators coupled via two mean fields. We derive stability properties of the incoherent state and find traveling wave solutions with different locking patterns; stability properties of these waves are found numerically. Mostly nontrivial states appear when the two fields compete, i.e. one tends to synchronize oscillators while the other one desynchronizes them. Here we identify normal branches which bifurcate from the incoherent state in a usual way, and anomalous branches, appearance of which cannot be described as a bifurcation. Furthermore, hybrid branches combining properties of both are described. In the situations where no stable traveling wave exists, modulated quasiperiodic in time dynamics is observed. Our results indicate that a competition between two coupling channels can lead to a complex system behavior, providing a potential generalized framework for understanding of complex phenomena in natural oscillatory systems. Y1 - 2017 U6 - https://doi.org/10.1038/s41598-017-02283-1 SN - 2045-2322 VL - 7 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Zhang, Weiyi A1 - Willa, Christoph A1 - Sun, Jian-Ke A1 - Guterman, Ryan A1 - Taubert, Andreas A1 - Yuan, Jiayin T1 - Polytriazolium poly(ionic liquid) bearing triiodide anions: Synthesis, basic properties and electrochemical behaviors JF - Polymer : the international journal for the science and technology of polymers N2 - 4-Methyl-1-vinyl-1,2,4-triazolium triiodide ionic liquid and its polymer poly(4-methyl-1-vinyl-1,2,4-triazolium) triiodide were prepared for the first time from their iodide precursors via the reaction of iodide (I-) with elemental iodine (I-2). The change from iodide to triiodide (I-3(-)) was found to introduce particular variations in the physical properties of these two compounds, including lower melting point/glass transition temperature and altered solubility. The compounds were characterized by single-crystal X-ray diffraction, elemental analysis, and their electrochemical properties examined in solution and in the solid-state. Compared with their iodide analogues, the triiodide salts exhibited lower electrical impedance and higher current in the cyclic voltammetry. We found that poly(4-methyl-1,2,4-triazolium triiodide) was proven to be a promising solid polymer electrolyte candidate. (C) 2017 Elsevier Ltd. All rights reserved. KW - Poly(ionic liquid) KW - Solid polymer electrolyte KW - Grotthuss mechanism KW - Triiodide "network" Y1 - 2017 U6 - https://doi.org/10.1016/j.polymer.2017.07.059 SN - 0032-3861 SN - 1873-2291 VL - 124 SP - 246 EP - 251 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Zhang, Shuhao A1 - Bisterfeld, Carolin A1 - Bramski, Julia A1 - Vanparijs, Nane A1 - De Geest, Bruno G. A1 - Pietruszka, Jörg A1 - Böker, Alexander A1 - Reinicke, Stefan T1 - Biocatalytically Active Thin Films via Self-Assembly of 2-Deoxy-D-ribose-5-phosphate Aldolase-Poly(N-isopropylacrylamide) Conjugates JF - Bioconjugate chemistry N2 - 2-Deoxy-D-ribose-5-phosphate aldolase (DERA) is a biocatalyst that is capable of converting acetaldehyde and a second aldehyde as acceptor into enantiomerically pure mono- and diyhydroxyaldehydes, which are important structural motifs in a number of pharmaceutically active compounds. However, substrate as well as product inhibition requires a more-sophisticated process design for the synthesis of these motifs. One way to do so is to the couple aldehyde conversion with transport processes, which, in turn, would require an immobilization of the enzyme within a thin film that can be deposited on a membrane support. Consequently, we developed a fabrication process for such films that is based on the formation of DERA-poly(N-isopropylacrylamide) conjugates that are subsequently allowed to self-assemble at an air-water interface to yield the respective film. In this contribution, we discuss the conjugation conditions, investigate the interfacial properties of the conjugates, and, finally, demonstrate a successful film formation under the preservation of enzymatic activity. Y1 - 2017 U6 - https://doi.org/10.1021/acs.bioconjchem.7b00645 SN - 1043-1802 VL - 29 IS - 1 SP - 104 EP - 116 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Zhang, Nan A1 - Said, Andre A1 - Wischke, Christian A1 - Kral, Vivian A1 - Brodwolf, Robert A1 - Volz, Pierre A1 - Boreham, Alexander A1 - Gerecke, Christian A1 - Li, Wenzhong A1 - Neffe, Axel T. A1 - Kleuser, Burkhard A1 - Alexiev, Ulrike A1 - Lendlein, Andreas A1 - Schäfer-Korting, Monika T1 - Poly[acrylonitrile-co-(N-vinyl pyrrolidone)] nanoparticles - Composition-dependent skin penetration enhancement of a dye probe and biocompatibility JF - European Journal of Pharmaceutics and Biopharmaceutics N2 - Nanoparticles can improve topical drug delivery: size, surface properties and flexibility of polymer nanoparticles are defining its interaction with the skin. Only few studies have explored skin penetration for one series of structurally related polymer particles with systematic alteration of material composition. Here, a series of rigid poly[acrylonitrile-co-(N-vinyl pyrrolidone)] model nanoparticles stably loaded with Nile Red or Rhodamin B, respectively, was comprehensively studied for biocompatibility and functionality. Surface properties were altered by varying the molar content of hydrophilic NVP from 0 to 24.1% and particle size ranged from 35 to 244 nm. Whereas irritancy and genotoxicity were not revealed, lipophilic and hydrophilic nanoparticles taken up by keratinocytes affected cell viability. Skin absorption of the particles into viable skin ex vivo was studied using Nile Red as fluorescent probe. Whilst an intact stratum corneum efficiently prevented penetration, almost complete removal of the horny layer allowed nanoparticles of smaller size and hydrophilic particles to penetrate into viable epidermis and dermis. Hence, systematic variations of nanoparticle properties allows gaining insights into critical criteria for biocompatibility and functionality of novel nanocarriers for topical drug delivery and risks associated with environmental exposure. KW - Biocompatibility testing KW - Drug delivery systems KW - Nanoparticle KW - Poly[acrylonitrile-co-(N-vinyl pyrrolidone)] KW - Polymers KW - Skin absorption Y1 - 2017 U6 - https://doi.org/10.1016/j.ejpb.2016.10.019 SN - 0939-6411 SN - 1873-3441 VL - 116 SP - 66 EP - 75 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Zhang, Kai A1 - Chen, Zhiming A1 - Armin, Ardalan A1 - Dong, Sheng A1 - Xia, Ruoxi A1 - Yip, Hin-Lap A1 - Shoaee, Safa A1 - Huang, Fei A1 - Cao, Yong T1 - Efficient large area organic solar cells processed by blade-coating with single-component green solvent JF - Solar Rrl N2 - While the performance of laboratory-scale organic solar cells (OSCs) continues to grow, development of high efficiency large area OSCs remains a big challenge. Although a few attempts to produce large area organic solar cells (OSCs) have been reported, there are still challenges on the way to realizing efficient module devices, such as the low compatibility of the thickness-sensitive active layer with large area coating techniques, the frequent need for toxic solvents and tedious optimization processes used during device fabrication. In this work, highly efficient thickness-insensitive OSCs based on PTB7-Th:PC71BM that processed with single-component green solvent 2-methylanisole are presented, in which both junction thickness limitation and solvent toxicity issues are simultaneously addressed. Careful investigation reveals that this green solvent prevents the evolution of PC71BM into large area clusters resulting in reduced charge carrier recombination, and largely eliminates trapping centers, and thus improves the thickness tolerance of the films. These findings enable us to address the scalability and solvent toxicity issues and to fabricate a 16 cm(2) OSC with doctor-blade coating with a state-of-the-art power conversion efficiency of 7.5% using green solvent. KW - doctor-blade coating KW - green solvents KW - large area devices KW - organic solar cells KW - thickness insensitive active layers Y1 - 2017 U6 - https://doi.org/10.1002/solr.201700169 SN - 2367-198X VL - 2 IS - 1 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Zeng, Ting A1 - Leimkühler, Silke A1 - Wollenberger, Ulla A1 - Fourmond, Vincent T1 - Transient Catalytic Voltammetry of Sulfite Oxidase Reveals Rate Limiting Conformational Changes JF - Journal of the American Chemical Society N2 - Sulfite oxidases are metalloenzymes that oxidize sulfite to sulfate at a molybdenum active site. In vertebrate sulfite oxidases, the electrons generated at the Mo center are transferred to an external electron acceptor via a heme domain, which can adopt two conformations: a “closed” conformation, suitable for internal electron transfer, and an “open” conformation suitable for intermolecular electron transfer. This conformational change is an integral part of the catalytic cycle. Sulfite oxidases have been wired to electrode surfaces, but their immobilization leads to a significant decrease in their catalytic activity, raising the question of the occurrence of the conformational change when the enzyme is on an electrode. We recorded and quantitatively modeled for the first time the transient response of the catalytic cycle of human sulfite oxidase immobilized on an electrode. We show that conformational changes still occur on the electrode, but at a lower rate than in solution, which is the reason for the decrease in activity of sulfite oxidases upon immobilization. Y1 - 2017 U6 - https://doi.org/10.1021/jacs.7b05480 SN - 0002-7863 VL - 139 SP - 11559 EP - 11567 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Zantke, Michael T1 - Bolschewismus von rechts BT - deutsche Konservative und die Oktoberrevolution JF - WeltTrends : das außenpolitische Journal Y1 - 2017 SN - 973-3-945878-67-5 SN - 0944-8101 VL - 25 IS - 132 SP - 33 EP - 36 PB - WeltTrends CY - Potsdam ER - TY - JOUR A1 - Zang, Arno A1 - Stephansson, Ove A1 - Stenberg, Leif A1 - Plenkers, Katrin A1 - von Specht, Sebastian A1 - Milkereit, Claus A1 - Schill, Eva A1 - Kwiatek, Grzegorz A1 - Dresen, Georg A1 - Zimmermann, Günter A1 - Dahm, Torsten A1 - Weber, Michael T1 - Hydraulic fracture monitoring in hard rock at 410 m depth with an advanced fluid-injection protocol and extensive sensor array JF - Geophysical journal international N2 - In this paper, an underground experiment at the Aspo Hard Rock Laboratory (HRL) is described. Main goal is optimizing geothermal heat exchange in crystalline rock mass at depth by multistage hydraulic fracturing with minimal impact on the environment, that is, seismic events. For this, three arrays with acoustic emission, microseismicity and electromagnetic sensors are installed mapping hydraulic fracture initiation and growth. Fractures are driven by three different water injection schemes (continuous, progressive and pulse pressurization). After a brief review of hydraulic fracture operations in crystalline rock mass at mine scale, the site geology and the stress conditions at Aspo HRL are described. Then, the continuous, single-flow rate and alternative, multiple-flow rate fracture breakdown tests in a horizontal borehole at depth level 410 m are described together with the monitoring networks and sensitivity. Monitoring results include the primary catalogue of acoustic emission hypocentres obtained from four hydraulic fractures with the in situ trigger and localizing network. The continuous versus alternative water injection schemes are discussed in terms of the fracture breakdown pressure, the fracture pattern from impression packer result and the monitoring at the arrays. An example of multistage hydraulic fracturing with several phases of opening and closing of fracture walls is evaluated using data from acoustic emissions, seismic broad-band recordings and electromagnetic signal response. Based on our limited amount of in situ tests (six) and evaluation of three tests in Avro granodiorite, in the multiple-flow rate test with progressively increasing target pressure, the acoustic emission activity starts at a later stage in the fracturing process compared to the conventional fracturing case with continuous water injection. In tendency, also the total number and magnitude of acoustic events are found to be smaller in the progressive treatment with frequent phases of depressurization. KW - Geomechanics KW - Fracture and flow KW - Broad-band seismometers Y1 - 2016 SN - 0956-540X SN - 1365-246X VL - 208 SP - 790 EP - 813 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Zaks, Michael A1 - Pikovskij, Arkadij T1 - Chimeras and complex cluster states in arrays of spin-torque oscillators JF - Scientific reports N2 - We consider synchronization properties of arrays of spin-torque nano-oscillators coupled via an RC load. We show that while the fully synchronized state of identical oscillators may be locally stable in some parameter range, this synchrony is not globally attracting. Instead, regimes of different levels of compositional complexity are observed. These include chimera states (a part of the array forms a cluster while other units are desynchronized), clustered chimeras (several clusters plus desynchronized oscillators), cluster state (all oscillators form several clusters), and partial synchronization (no clusters but a nonvanishing mean field). Dynamically, these states are also complex, demonstrating irregular and close to quasiperiodic modulation. Remarkably, when heterogeneity of spin-torque oscillators is taken into account, dynamical complexity even increases: close to the onset of a macroscopic mean field, the dynamics of this field is rather irregular. Y1 - 2017 U6 - https://doi.org/10.1038/s41598-017-04918-9 SN - 2045-2322 VL - 7 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Zaks, Michael A. A1 - Pikovskij, Arkadij T1 - Chimeras and complex cluster states in arrays of spin-torque oscillators JF - Scientific reports N2 - We consider synchronization properties of arrays of spin-torque nano-oscillators coupled via an RC load. We show that while the fully synchronized state of identical oscillators may be locally stable in some parameter range, this synchrony is not globally attracting. Instead, regimes of different levels of compositional complexity are observed. These include chimera states (a part of the array forms a cluster while other units are desynchronized), clustered chimeras (several clusters plus desynchronized oscillators), cluster state (all oscillators form several clusters), and partial synchronization (no clusters but a nonvanishing mean field). Dynamically, these states are also complex, demonstrating irregular and close to quasiperiodic modulation. Remarkably, when heterogeneity of spin-torque oscillators is taken into account, dynamical complexity even increases: close to the onset of a macroscopic mean field, the dynamics of this field is rather irregular. Y1 - 2017 U6 - https://doi.org/10.1038/s41598-017-04918-9 SN - 2045-2322 VL - 7 PB - Macmillan Publishers Limited CY - London ER - TY - JOUR A1 - Zacharias, Michael A1 - Chen, Xuhui A1 - Wagner, Stefan T1 - Attenuation of TeV gamma-rays by the starlight photon field of the host galaxy JF - Monthly notices of the Royal Astronomical Society N2 - The absorption of TeV gamma-ray photons produced in relativistic jets by surrounding soft photon fields is a long-standing problem of jet physics. In some cases, the most likely emission site close to the central black hole is ruled out because of the high opacity caused by strong optical and infrared photon sources, such as the broad-line region. Mostly neglected for jet modelling is the absorption of gamma-rays in the starlight photon field of the host galaxy. Analysing the absorption for arbitrary locations and observation angles of the gamma-ray emission site within the host galaxy, we find that the distance to the galaxy centre, the observation angle, and the distribution of starlight in the galaxy are crucial for the amount of absorption. We derive the absorption value for a sample of 20 TeV-detected blazars with a redshift z(r) < 0.2. The absorption value of the gamma-ray emission located in the galaxy centre may be as high as 20 per cent, with an average value of 6 per cent. This is important in order to determine the intrinsic blazar parameters. We see no significant trends in our sample between the degree of absorption and host properties, such as starlight emissivity, galactic size, half-light radius, and redshift. While the uncertainty of the spectral properties of the extragalactic background light exceeds the effect of absorption by stellar light from the host galaxy in distant objects, the latter is a dominant effect in nearby sources. It may also be revealed in a differential comparison of sources with similar redshifts. KW - opacity KW - radiation mechanisms: non-thermal KW - galaxies: active KW - gamma-rays: galaxies Y1 - 2016 U6 - https://doi.org/10.1093/mnras/stw3032 SN - 0035-8711 SN - 1365-2966 VL - 465 IS - 3 SP - 3767 EP - 3774 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Yılmaz, Zafer T1 - The AKP and the spirit of the ‘new’ Turkey BT - imagined victim, reactionary mood, and resentful sovereign JF - Turkish studies N2 - A strong sense of victimhood, a discourse of social suffering, and complementary bodily performances, which mobilize rancor, resentfulness, and revengefulness, are fundamental elements of Turkish-Islamist ideology. This article discusses the political dynamics and implications of such assertions of victimhood in the Turkish context. To underscore these dynamics, it analyses the role of the logic of pain in the subject formation of Turkish-Islamist identity and how this logic has been revitalized by constitutive and hegemonic social imagination, and circulated and intensified by a reactionary mood. Additionally, it aims to expose how this reactionary mood profoundly depends on contradictory subjectification processes, which simultaneously involve mobilization of feelings of impotency, non-responsibility, self-pitying, and sublimation of power. This subject formation opens the way for identification with authoritarian figures in the Turkish case. KW - Justice and Development Party (AKP) KW - victimhood KW - resentment KW - reactionary mood KW - Turkish-Islamist ideology Y1 - 2017 U6 - https://doi.org/10.1080/14683849.2017.1314763 SN - 1468-3849 SN - 1743-9663 VL - 18 IS - 3 SP - 482 EP - 513 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Yue, Jinxing A1 - Alter, Kai-Uwe A1 - Howard, David A1 - Bastiaanse, Roelien T1 - Early access to lexical-level phonological representations of Mandarin word-forms BT - evidence from auditory N1 habituation JF - Language, cognition and neuroscience N2 - An auditory habituation design was used to investigate whether lexical-level phonological representations in the brain can be rapidly accessed after the onset of a spoken word. We studied the N1 component of the auditory event-related electrical potential, and measured the amplitude decrements of N1 associated with the repetition of a monosyllabic tone word and an acoustically similar pseudo-word in Mandarin Chinese. Effects related to the contrastive onset consonants were controlled for by introducing two control words. We show that repeated pseudo-words consistently elicit greater amplitude decrements in N1 than real words. Furthermore, this lexicality effect is free from sensory fatigue or rapid learning of the pseudo-word. These results suggest that a lexical-level phonological representation of a spoken word can be accessed as early as 110ms after the onset of the word-form. KW - Auditory N1 KW - short-term habituation KW - spoken word KW - Mandarin Chinese KW - language KW - event-related potential KW - lexical access Y1 - 2017 U6 - https://doi.org/10.1080/23273798.2017.1290261 SN - 2327-3798 SN - 2327-3801 VL - 32 IS - 9 SP - 1148 EP - 1163 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - You, Zewang A1 - Behl, Marc A1 - Löwenberg, Candy A1 - Lendlein, Andreas T1 - pH-sensitivity and conformation change of the n-terminal methacrylated peptide VK20 JF - MRS advances : a journal of the Materials Research Society (MRS) N2 - N-terminal methacrylation of peptide MAXI, which is capable of conformational changes variation of the pH, results in a peptide, named VK20. Increasing the reactivity of this terminal group enables further coupling reactions or chemical modifications of the peptidc. However, this end group functionalization may influence the ability of confonnational changes of VK20; as well as its properties. In this paper; the influence of pH on the transition between random coil and beta-sheet conformation of VK20; including the transition kinetics, were investigated. At pH values of 9 and higher, the kinetics beta-sheet formation increased tor VK(2 0, compared to MAXI. The self-assembly into beta-sheets recognized by the formation of a physically crosslinked gel was furthermore indicated by a significant increase of G. An increase in pH (from 9 to 9.5) led to a faster gelation of the peptide VK20. Simultaneously, G was increased from 460 +/- 70 Pa (at pH 9) to 1520 +/- 180 Pa (at pH 9.5). At the nanoscale, the gel showed a highly interconnected fibrillar/network structure with uniform fibril widths of approximately 3.4 +/- 0.5 nm (N=30). The recovery of the peptide conformation back to random coil resulted in the dissolution of the gel; whereby the kinetics of the recovery depended on the pH. Conclusively, the ability of MAXI to undergo confommtional changes was not affected by N-terminal methacrylation whereas the kinetics of pH-sensitive beta-sheet formations has been increased. Y1 - 2017 U6 - https://doi.org/10.1557/adv.2017.491 SN - 2059-8521 VL - 2 SP - 2571 EP - 2579 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Yoon, P. H. A1 - Lopez, R. A. A1 - Vafin, Sergei A1 - Kim, S. A1 - Schlickeiser, R. T1 - Spontaneous emission of Alfvenic fluctuations JF - Plasma physics and controlled fusion N2 - Low-frequency fluctuations are pervasively observed in the solar wind. The present paper theoretically calculates the steady state spectra of low-frequency electromagnetic (EM) fluctuations of the Alfvenic type for thermal equilibrium plasma. The analysis is based upon a recently formulated theory of spontaneously emitted EM fluctuations in magnetized thermal plasmas. It is found that the fluctuations in the magnetosonic mode branch is constant, while the kinetic Alfvenic mode spectrum is dependent on a form factor that is a function of perpendicular wave number. Potential applicability of the present work in the wider context of heliospheric research is also discussed. KW - spontaneous emission KW - kinetic Alfven KW - magnetosonic Y1 - 2017 U6 - https://doi.org/10.1088/1361-6587/aa77c3 SN - 0741-3335 SN - 1361-6587 VL - 59 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Yin, Zhong A1 - Inhester, Ludger A1 - Veedu, Sreevidya Thekku A1 - Quevedo, Wilson A1 - Pietzsch, Annette A1 - Wernet, Philippe A1 - Groenhof, Gerrit A1 - Föhlisch, Alexander A1 - Grubmueller, Helmut A1 - Techert, Simone T1 - Cationic and Anionic Impact on the Electronic Structure of Liquid Water JF - The journal of physical chemistry letters N2 - Hydration shells around ions are crucial for many fundamental biological and chemical processes. Their local physicochemical properties are quite different from those of bulk water and hard to probe experimentally. We address this problem by combining soft X-ray spectroscopy using a liquid jet and molecular dynamics (MD) simulations together with ab initio electronic structure calculations to elucidate the water ion interaction in a MgCl2 solution at the molecular level. Our results reveal that salt ions mainly affect the electronic properties of water molecules in close vicinity and that the oxygen K-edge X-ray emission spectrum of water molecules in the first solvation shell differs significantly from that of bulk water. Ion-specific effects are identified by fingerprint features in the water X-ray emission spectra. While Mg2+ ions cause a bathochromic shift of the water lone pair orbital, the 3p orbital of the Cl- ions causes an additional peak in the water emission spectrum at around 528 eV. Y1 - 2017 U6 - https://doi.org/10.1021/acs.jpclett.7b01392 SN - 1948-7185 VL - 8 SP - 3759 EP - 3764 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Yarman, Aysu T1 - Development of a molecularly imprinted polymer-based electrochemical sensor for tyrosinase JF - Turkish journal of chemistry N2 - For the first time a molecularly imprinted polymer (MIP)-based sensor for tyrosinase is described. This sensor is based on the electropolymerization of scopoletin or o-phenylenediamine in the presence of tyrosinase from mushrooms, which has a high homology to the human enzyme. The template was removed either by treatment with proteinase Kor by alkaline treatment. The measuring signal was generated either by measuring the formation of a product by the target enzyme or by evaluation of the permeability of the redox marker ferricyanide. The o-phenylenediamine-based MIP sensor has a linear measuring range up to 50 nM of tyrosinase with a limit of detection of 3.97 nM (R 2 = 0.994) and shows good discrimination towards other proteins, e.g., bovine serum albumin and cytochrome c. KW - Molecularly imprinted polymers KW - biomimetic sensors KW - tyrosinase KW - electropolymerization KW - scopoletin KW - ophenylenediamine Y1 - 2017 U6 - https://doi.org/10.3906/kim-1708-68 SN - 1300-0527 VL - 42 IS - 2 SP - 346 EP - 354 PB - Türkiye Bilimsel ve Teknik Araştırma Kurumu CY - Ankara ER - TY - JOUR A1 - Yang, Guang A1 - Ding, Hong-ming A1 - Kochovski, Zdravko A1 - Hu, Rongting A1 - Lu, Yan A1 - Ma, Yu-qiang A1 - Chen, Guosong A1 - Jiang, Ming T1 - Highly Ordered Self-Assembly of Native Proteins into 1D, 2D, and 3D Structures Modulated by the Tether Length of Assembly-Inducing Ligands JF - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition N2 - In nature, proteins self-assemble into various structures with different dimensions. To construct these nanostructures in laboratories, normally proteins with different symmetries are selected. However, most of these approaches are engineering-intensive and highly dependent on the accuracy of the protein design. Herein, we report that a simple native protein LecA assembles into one-dimensional nanoribbons and nanowires, two-dimensional nanosheets, and three-dimensional layered structures controlled mainly by small-molecule assembly-inducing ligands RnG (n = 1, 2, 3, 4, 5) with varying numbers of ethylene oxide repeating units. To understand the formation mechanism of the different morphologies controlled by the small-molecule structure, molecular simulations were performed from microscopic and mesoscopic view, which presented a clear relationship between the molecular structure of the ligands and the assembled patterns. These results introduce an easy strategy to control the assembly structure and dimension, which could shed light on controlled protein assembly. KW - carbohydrate-protein interactions KW - dual non-covalent interactions KW - molecular simulations KW - protein self-assembly Y1 - 2017 U6 - https://doi.org/10.1002/anie.201703052 SN - 1433-7851 SN - 1521-3773 VL - 56 SP - 10691 EP - 10695 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Yan, Wan A1 - Fang, Liang A1 - Weigel, Thomas A1 - Behl, Marc A1 - Kratz, Karl A1 - Lendlein, Andreas T1 - The influence of thermal treatment on the morphology in differently prepared films of a oligodepsipeptide based multiblock copolymer JF - Polymers for advanced technologies N2 - Degradable multiblock copolymers prepared from equal weight amounts of poly(epsilon-caprolactone)-diol (PCL-diol) and poly[oligo(3S-iso-butylmorpholine-2,5-dione)]-diol (PIBMD-diol), named PCL-PIBMD, provide a phase-segregated morphology. It exhibits a low melting temperature from PCL domains (T-m,T-PCL) of 382 degrees C and a high T-m,T-PIBMD of 170 +/- 2 degrees C with a glass transition temperature (T-g,T-PIBMD) at 42 +/- 2 degrees C from PIBMD domains. In this study, we explored the influence of applying different thermal treatments on the resulting morphologies of solution-cast and spin-coated PCL-PIBMD thin films, which showed different initial surface morphologies. Differential scanning calorimetry results and atomic force microscopy images after different thermal treatments indicated that PCL and PIBMD domains showed similar crystallization behaviors in 270 +/- 30 mu m thick solution-cast films as well as in 30 +/- 2 and 8 +/- 1nm thick spin-coated PCL-PIBMD films. Existing PIBMD crystalline domains highly restricted the generation of PCL crystalline domains during cooling when the sample was annealed at 180 degrees C. By annealing the sample above 120 degrees C, the PIBMD domains crystallized sufficiently and covered the free surface, which restricted the crystallization of PCL domains during cooling. The PCL domains can crystallize by hindering the crystallization of PIBMD domains via the fast vitrification of PIBMD domains when the sample was cooled/quenched in liquid nitrogen after annealing at 180 degrees C. These findings contribute to a better fundamental understanding of the crystallization mechanism of multi-block copolymers containing two crystallizable domains whereby the T-g of the higher melting domain type is in the same temperature range as the T-m of the lower melting domain type. Copyright (c) 2016 John Wiley & Sons, Ltd. KW - multiblock copolymer KW - oligodepsipeptides KW - phase morphology KW - thermal treatments KW - crystallization behavior Y1 - 2017 U6 - https://doi.org/10.1002/pat.3953 SN - 1042-7147 SN - 1099-1581 VL - 28 SP - 1339 EP - 1345 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Yamazaki, Yosuke A1 - Stolle, Claudia A1 - Matzka, Jürgen A1 - Siddiqui, Tarique Adnan A1 - Luehr, Hermann A1 - Alken, Patrick T1 - Longitudinal Variation of the Lunar Tide in the Equatorial Electrojet JF - Journal of geophysical research : Space physics N2 - The atmospheric lunar tide is one known source of ionospheric variability. The subject received renewed attention as recent studies found a link between stratospheric sudden warmings and amplified lunar tidal perturbations in the equatorial ionosphere. There is increasing evidence from ground observations that the lunar tidal influence on the ionosphere depends on longitude. We use magnetic field measurements from the CHAMP satellite during July 2000 to September 2010 and from the two Swarm satellites during November 2013 to February 2017 to determine, for the first time, the complete seasonal- longitudinal climatology of the semidiurnal lunar tidal variation in the equatorial electrojet intensity. Significant longitudinal variability is found in the amplitude of the lunar tidal variation, while the longitudinal variability in the phase is small. The amplitude peaks in the Peruvian sector (similar to 285 degrees E) during the Northern Hemisphere winter and equinoxes, and in the Brazilian sector (similar to 325 degrees E) during the Northern Hemisphere summer. There are also local amplitude maxima at similar to 55 degrees E and similar to 120 degrees E. The longitudinal variation is partly due to the modulation of ionospheric conductivities by the inhomogeneous geomagnetic field. Another possible cause of the longitudinal variability is neutral wind forcing by nonmigrating lunar tides. A tidal spectrum analysis of the semidiurnal lunar tidal variation in the equatorial electrojet reveals the dominance of the westward propagating mode with zonal wave number 2 (SW2), with secondary contributions by westward propagating modes with zonal wave numbers 3 (SW3) and 4 (SW4). Eastward propagating waves are largely absent from the tidal spectrum. Further study will be required for the relative importance of ionospheric conductivities and nonmigrating lunar tides. Y1 - 2017 U6 - https://doi.org/10.1002/2017JA024601 SN - 2169-9380 SN - 2169-9402 VL - 122 SP - 12445 EP - 12463 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Xu, Mei A1 - Lu, Yong-Ping A1 - Hasan, Ahmed A. A1 - Hocher, Berthold T1 - Plasma ET-1 concentrations are elevated in patients with hypertension meta-analysis of clinical studies JF - Kidney & blood pressure research : official organ of the Gesellschaft für Nephrologie ; official organ of the Deutsche Liga zur Bekämpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft N2 - Background/Aims: A recent study revealed that global overexpression of ET-1 causes a slight reduction in systemic blood pressure. Moreover, heterozygous ET-1 knockout mice are hypertensive. The role of ET-1 in human hypertension was so far not addressed by a strict meta-analysis of published human clinical studies. Methods: We included studies published between January 1, 1990 and February 28, 2017. We included case control studies analyzing untreated essential hypertension or hypertensive patients where antihypertensive medication was discontinued for at least two weeks. Based on the principle of Cochrane systematic reviews, case control studies (CCSs) in PubMed (Medline) and Google Scholar designed to identify the role of endothelin-1 (ET-1) in the pathophysiological of hypertension were screened. Review Manager Version 5.0 (Rev-Man 5.0) was applied for statistical analysis. Mean difference and 95% confidence interval (CI) were shown in inverse variance (IV) fixed-effects model or IV random-effects models. Results: Eleven studies fulfilling our in-and exclusion criteria were eligible for this meta-analysis. These studies included 450 hypertensive patients and 328 controls. Our meta-analysis revealed that ET-1 plasma concentrations were higher in hypertensive patients as compared to the control patients [mean difference between groups 1.57 pg/mL, 95%Ci [0.47 similar to 2.68, P = 0.005]. These finding were driven by patients having systolic blood pressure higher than 160 mmHg and diastolic blood pressure higher than 100 mmHg. Conclusions: This meta-analysis showed that hypertensive patients do have elevated plasma ET-1 concentrations. This finding is driven by those patients with high systolic/diastolic blood pressure. Given that the ET-1 gene did not appear in any of the whole genome association studies searching for hypertension associated gene loci, it is very likely that the elevated plasma ET-1 concentrations in hypertensive patients are secondary to hypertension and may reflect endothelial cell damage. KW - Hypertension KW - ET-1 KW - Meta-analysis Y1 - 2017 U6 - https://doi.org/10.1159/000477572 SN - 1420-4096 SN - 1423-0143 VL - 42 IS - 2 SP - 304 EP - 313 PB - Karger CY - Basel ER - TY - JOUR A1 - Xiong, Hui A1 - Mignolet, Benoit A1 - Fang, Li A1 - Osipov, Timur A1 - Wolf, Thomas J. A. A1 - Sistrunk, Emily A1 - Gühr, Markus A1 - Remacle, Francoise A1 - Berrah, Nora T1 - The Role of Super-Atom Molecular Orbitals in Doped Fullerenes in a Femtosecond Intense Laser Field JF - Scientific reports N2 - The interaction of gas phase endohedral fullerene Ho3N@C-80 with intense (0.1-5 x 10(14) W/cm(2)), short (30 fs), 800 nm laser pulses was investigated. The power law dependence of Ho3N@C-80(q+), q = 1-2, was found to be different from that of C-60. Time-dependent density functional theory computations revealed different light-induced ionization mechanisms. Unlike in C-60, in doped fullerenes, the breaking of the cage spherical symmetry makes super atomic molecular orbital (SAMO) states optically active. Theoretical calculations suggest that the fast ionization of the SAMO states in Ho3N@C-80 is responsible for the n = 3 power law for singly charged parent molecules at intensities lower than 1.2 x 10(14) W/cm(2). Y1 - 2017 U6 - https://doi.org/10.1038/s41598-017-00124-9 SN - 2045-2322 VL - 7 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Xiang, Hai A1 - Gao, Jianqiang A1 - Cai, Dawei A1 - Luo, Yunbing A1 - Yu, Baoquan A1 - Liu, Langqing A1 - Liu, Ranran A1 - Zhou, Hui A1 - Chen, Xiaoyong A1 - Dun, Weitao A1 - Wang, Xi A1 - Hofreiter, Michael A1 - Zhao, Xingbo T1 - Origin and dispersal of early domestic pigs in northern China JF - Scientific reports N2 - It is widely accepted that modern pigs were domesticated independently at least twice, and Chinese native pigs are deemed as direct descendants of the first domesticated pigs in the corresponding domestication centers. By analyzing mitochondrial DNA sequences of an extensive sample set spanning 10,000 years, we find that the earliest pigs from the middle Yellow River region already carried the maternal lineages that are dominant in both younger archaeological populations and modern Chinese pigs. Our data set also supports early Neolithic pig utilization and a long-term in situ origin for northeastern Chinese pigs during 8,000-3,500 BP, suggesting a possibly independent domestication in northeast China. Additionally, we observe a genetic replacement in ancient northeast Chinese pigs since 3,500 BP. The results not only provide increasing evidence for pig origin in the middle Yellow River region but also depict an outline for the process of early pig domestication in northeast China. Y1 - 2017 U6 - https://doi.org/10.1038/s41598-017-06056-8 SN - 2045-2322 VL - 7 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Wyschkon, Anne A1 - Schulz, Franziska A1 - Gallit, Finja Sunnyi A1 - Poltz, Nadine A1 - Kohn-Henkel, Juliane A1 - Moraske, Svenja A1 - Bondü, Rebecca A1 - von Aster, Michael G. A1 - Esser, Günter T1 - 5-Jahres-Verlauf der LRS T1 - 5-year course of dyslexia BT - Stabilität, Geschlechtseffekte, Schriftsprachniveau und Schulerfolg BT - Persistence, sex effects, performance in reading and spelling, and school-related success JF - Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie N2 - Fragestellung: Untersucht wird der Verlauf von Kindern mit Lese-Rechtschreibstörungen (LRS) über gut 5 Jahre unter Berücksichtigung des Einflusses des Geschlechts der Betroffenen. Außerdem werden Auswirkungen der LRS auf das spätere Schriftsprachniveau und den Schulerfolg überprüft. Methodik: Eingangs wurden 995 Schüler zwischen 6 und 16 Jahren untersucht. Ein Teil dieser Kinder ist nach 43 sowie 63 Monaten nachuntersucht worden. Eine LRS wurde diagnostiziert, wenn für das Lesen bzw. Rechtschreiben das doppelte Diskrepanzkriterium von 1.5 Standardabweichungen zur nonverbalen Intelligenz und dem Mittelwert der Klassenstufe erfüllt war und gleichzeitig keine Minderbegabung vorlag. Ergebnisse: Die LRS weist über einen Zeitraum von 63 Monaten eine hohe Störungspersistenz von knapp 70 % auf. Der 5-Jahres-Verlauf der mittleren Lese- und Rechtschreibleistungen wurde nicht vom Geschlecht beeinflusst. Trotz durchschnittlicher Intelligenz blieben die LRS-Schüler in der Schriftsprache mindestens eine Standardabweichung hinter durchschnittlich und etwa 0.5 Standardabweichungseinheiten hinter unterdurchschnittlich intelligenten Kindern zurück. Der Schulerfolg der LRS-Schüler glich dem unterdurchschnittlich intelligenter Kinder und fiel deutlich schlechter aus als bei durchschnittlich intelligenten Kontrollkindern. Schlussfolgerungen: Eine LRS stellt ein erhebliches Entwicklungsrisiko dar, was frühzeitige Diagnostik- und Therapiemaßnahmen erfordert. Dafür sind reliable und im Hinblick auf die resultierenden Prävalenzraten sinnvolle, allgemein anerkannte Diagnosekriterien essenziell. N2 - Objective: The study examines the 5-year course of children with dyslexia with regard to their sex. Furthermore, the study investigates the impact of dyslexia on the performance in reading and spelling skills and school-related success. Method: A group of 995 6- to 16-year-olds were examined at the initial assessment. Part of the initial sample was then re-examined after 43 and 63 months. The diagnosis of dyslexia was based on the double discrepancy criterion using a standard deviation of 1.5. Though they had no intellectual deficits, the children showed a considerable discrepancy between their reading or writing abilities and (1) their nonverbal intelligence and (2) the mean of their grade norm. Results: Nearly 70 % of those examined had a persisting diagnosis of dyslexia over a period of 63 months. The 5-year course was not influenced by sex. Despite average intelligence, the performance in writing and spelling of children suffering from dyslexia was one standard deviation below a control group without dyslexia with average intelligence and 0.5 standard deviations below a group of children suffering from intellectual deficits. Furthermore, the school-related success of the dyslexics was significantly lower than those of children with average intelligence. Dyslexics showed similar school-related success rates to children suffering from intellectual deficits. Conclusions: Dyslexia represents a considerable developmental risk. The adverse impact of dyslexia on school-related success supports the importance of early diagnostics and intervention. It also underlines the need for reliable and general accepted diagnostic criteria. It is important to define such criteria in light of the prevalence rates. KW - dyslexia KW - discrepancy criterion KW - persistence KW - course KW - school-related success KW - Lese-Rechtschreibstörung KW - Diskreptanzdefinition KW - Stabilität KW - Verlauf KW - Schulerfolg Y1 - 2017 U6 - https://doi.org/10.1024/1422-4917/a000535 SN - 1422-4917 SN - 1664-2880 VL - 46 IS - 2 SP - 107 EP - 122 PB - Hogrefe CY - Bern ER - TY - JOUR A1 - Wyrwa, Ulrich T1 - Zum Hundertsten nichts Neues T1 - For the Hundredth nothing BT - Deutschsprachige Neuerscheinungen zum Ersten Weltkrieg (Teil III) BT - New German Language New Releases to the First World War (Part III) JF - Deutsche Zeitschrift für Geschichtswissenschaft Y1 - 2017 SN - 0044-2828 VL - 65 IS - 11 SP - 955 EP - 976 PB - Metropol-Verl. CY - Berlin ER - TY - JOUR A1 - Wurzbacher, Christian A1 - Fuchs, Andrea A1 - Attermeyer, Katrin A1 - Frindte, Katharina A1 - Grossart, Hans-Peter A1 - Hupfer, Michael A1 - Casper, Peter A1 - Monaghan, Michael T. T1 - Shifts among Eukaryota, Bacteria, and Archaea define the vertical organization of a lake sediment JF - Microbiome N2 - Background: Lake sediments harbor diverse microbial communities that cycle carbon and nutrients while being constantly colonized and potentially buried by organic matter sinking from the water column. The interaction of activity and burial remained largely unexplored in aquatic sediments. We aimed to relate taxonomic composition to sediment biogeochemical parameters, test whether community turnover with depth resulted from taxonomic replacement or from richness effects, and to provide a basic model for the vertical community structure in sediments. Methods: We analyzed four replicate sediment cores taken from 30-m depth in oligo-mesotrophic Lake Stechlin in northern Germany. Each 30-cm core spanned ca. 170 years of sediment accumulation according to Cs-137 dating and was sectioned into layers 1-4 cm thick. We examined a full suite of biogeochemical parameters and used DNA metabarcoding to examine community composition of microbial Archaea, Bacteria, and Eukaryota. Results: Community beta-diversity indicated nearly complete turnover within the uppermost 30 cm. We observed a pronounced shift from Eukaryota- and Bacteria-dominated upper layers (<5 cm) to Bacteria-dominated intermediate layers (5-14 cm) and to deep layers (>14 cm) dominated by enigmatic Archaea that typically occur in deep-sea sediments. Taxonomic replacement was the prevalent mechanism in structuring the community composition and was linked to parameters indicative of microbial activity (e.g., CO2 and CH4 concentration, bacterial protein production). Richness loss played a lesser role but was linked to conservative parameters (e.g., C, N, P) indicative of past conditions. Conclusions: By including all three domains, we were able to directly link the exponential decay of eukaryotes with the active sediment microbial community. The dominance of Archaea in deeper layers confirms earlier findings from marine systems and establishes freshwater sediments as a potential low-energy environment, similar to deep sea sediments. We propose a general model of sediment structure and function based on microbial characteristics and burial processes. An upper "replacement horizon" is dominated by rapid taxonomic turnover with depth, high microbial activity, and biotic interactions. A lower "depauperate horizon" is characterized by low taxonomic richness, more stable "low-energy" conditions, and a dominance of enigmatic Archaea. KW - Archaea KW - Eukaryota KW - Bacteria KW - Community KW - Freshwater KW - Lake KW - DNA metabarcoding KW - Beta-diversity KW - Sediment KW - Turnover Y1 - 2017 U6 - https://doi.org/10.1186/s40168-017-0255-9 SN - 2049-2618 VL - 5 PB - BioMed Central CY - London ER - TY - JOUR A1 - Wurzbacher, Christian A1 - Attermeyer, Katrin A1 - Kettner, Marie Therese A1 - Flintrop, Clara A1 - Warthmann, Norman A1 - Hilt, Sabine A1 - Grossart, Hans-Peter A1 - Monaghan, Michael T. T1 - DNA metabarcoding of unfractionated water samples relates phyto-, zoo- and bacterioplankton dynamics and reveals a single-taxon bacterial bloom JF - Environmental microbiology reports N2 - Most studies of aquatic plankton focus on either macroscopic or microbial communities, and on either eukaryotes or prokaryotes. This separation is primarily for methodological reasons, but can overlook potential interactions among groups. Here we tested whether DNA metabarcoding of unfractionated water samples with universal primers could be used to qualitatively and quantitatively study the temporal dynamics of the total plankton community in a shallow temperate lake. Significant changes in the relative proportions of normalized sequence reads of eukaryotic and prokaryotic plankton communities over a 3-month period in spring were found. Patterns followed the same trend as plankton estimates measured using traditional microscopic methods. The bloom of a conditionally rare bacterial taxon belonging to Arcicella was characterized, which rapidly came to dominate the whole lake ecosystem and would have remained unnoticed without metabarcoding. The data demonstrate the potential of universal DNA metabarcoding applied to unfractionated samples for providing a more holistic view of plankton communities. Y1 - 2017 U6 - https://doi.org/10.1111/1758-2229.12540 SN - 1758-2229 VL - 9 SP - 383 EP - 388 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Wurster, Sebastian A1 - Richter, Dirk A1 - Lenski, Anna Eva T1 - Teachers' use of evaluation data to improve instruction and its relationship to student achievement JF - Zeitschrift für Erziehungswissenschaft N2 - In Deutschland stehen Lehrkräften mit Ergebnissen aus Vergleichsarbeiten, zentralen Abschlussprüfungen und internen Evaluationen verschiedene Informationen zur Verfügung. Diese Daten können von ihnen dazu verwendet werden, den eigenen Unterricht zu reflektieren und weiterzuentwickeln. Die Studie geht auf Basis des IQB-Ländervergleichs 2012 den Fragen nach, ob und welche Daten von Lehrkräften zur Unterrichtsentwicklung herangezogen werden und ob datenbasierte Unterrichtsentwicklung mit Schülerleistung zusammenhängt. Die Betrachtung mehrerer Evaluationsverfahren ermöglicht eine kontrastierende Analyse und die Untersuchung einer gemeinsamen Verwendung mehrerer Informationsquellen. Die überwiegende Mehrheit der befragten Lehrkräfte berichtet, Evaluationsergebnisse als Ausgangspunkt zur Unterrichtsentwicklung zu verwenden. Allerdings zeigt sich Heterogenität zwischen einzelnen Unterrichtsentwicklungsaktivitäten und Lehrkräften. Zur Initiierung einzelner Entwicklungsaktivitäten werden auch mehrere Datenquellen simultan herangezogen. Ein direkter signifikanter Zusammenhang zwischen datenbasierter Unterrichtsentwicklung und Schülerleistung kann nicht festgestellt werden. (DIPF/Orig.). KW - Centralized examinations KW - Data-based decision making KW - Self-evaluation KW - State-wide comparison tests Y1 - 2017 U6 - https://doi.org/10.1007/s11618-017-0759-x SN - 1434-663X SN - 1862-5215 VL - 20 SP - 628 EP - 650 PB - Springer CY - Wiesbaden ER - TY - JOUR A1 - Wu, Yabin A1 - Stoddart, Martin J. A1 - Wuertz-Kozak, Karin A1 - Grad, Sibylle A1 - Alini, Mauro A1 - Ferguson, Stephen J. T1 - Hyaluronan supplementation as a mechanical regulator of cartilage tissue development under joint-kinematic-mimicking loading JF - Interface : journal of the Royal Society KW - synovial fluid KW - cartilage tissue engineering KW - mechanical loading KW - non-Newtonian fluid KW - hyaluronic acid supplementation Y1 - 2017 U6 - https://doi.org/10.1098/rsif.2017.0255 SN - 1742-5689 SN - 1742-5662 VL - 14 PB - Royal Society CY - London ER -