TY  - GEN
A1  - Wippert, Pia-Maria
A1  - Rector, Michael V.
A1  - Kuhn, Gisela
A1  - Wuertz-Kozak, Karin
T1  - Stress and Alterations in Bones
BT  - An Interdisciplinary Perspective
N2  - Decades of research have demonstrated that physical stress (PS) stimulates bone remodeling and affects bone structure and function through complex mechanotransduction mechanisms. Recent research has laid ground to the hypothesis that mental stress (MS) also influences bone biology, eventually leading to osteoporosis and increased bone fracture risk. These effects are likely exerted by modulation of hypothalamic–pituitary–adrenal axis activity, resulting in an altered release of growth hormones, glucocorticoids and cytokines, as demonstrated in human and animal studies. Furthermore, molecular cross talk between mental and PS is thought to exist, with either synergistic or preventative effects on bone disease progression depending on the characteristics of the applied stressor. This mini review will explain the emerging concept of MS as an important player in bone adaptation and its potential cross talk with PS by summarizing the current state of knowledge, highlighting newly evolving notions (such as intergenerational transmission of stress and its epigenetic modifications affecting bone) and proposing new research directions.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 323 
KW  - biomechanics
KW  - bone–brain–nervous system interactions
KW  - endocrine pathways
KW  - exercise
KW  - osteoporosis
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-395866
ER  - 
TY  - JOUR
A1  - Wippert, Pia-Maria
A1  - Rector, Michael V.
A1  - Kuhn, Gisela
A1  - Wuertz-Kozak, Karin
T1  - Stress and Alterations in Bones
BT  - An Interdisciplinary Perspective
JF  - Frontiers in endocrinology
N2  - Decades of research have demonstrated that physical stress (PS) stimulates bone remodeling and affects bone structure and function through complex mechanotransduction mechanisms. Recent research has laid ground to the hypothesis that mental stress (MS) also influences bone biology, eventually leading to osteoporosis and increased bone fracture risk. These effects are likely exerted by modulation of hypothalamic–pituitary–adrenal axis activity, resulting in an altered release of growth hormones, glucocorticoids and cytokines, as demonstrated in human and animal studies. Furthermore, molecular cross talk between mental and PS is thought to exist, with either synergistic or preventative effects on bone disease progression depending on the characteristics of the applied stressor. This mini review will explain the emerging concept of MS as an important player in bone adaptation and its potential cross talk with PS by summarizing the current state of knowledge, highlighting newly evolving notions (such as intergenerational transmission of stress and its epigenetic modifications affecting bone) and proposing new research directions.
KW  - biomechanics
KW  - bone–brain–nervous system interactions
KW  - endocrine pathways
KW  - osteoporosis
KW  - exercise
Y1  - 2017
U6  - https://doi.org/10.3389/fendo.2017.00096
SN  - 1664-2392
VL  - 8
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -