TY - JOUR A1 - Heidler, Maria-Dorothea A1 - Bidu, Laura A1 - Völler, Heinz A1 - Salzwedel, Annett T1 - Prädiktoren des kognitiven Outcomes beatmeter Frührehabilitationspatienten T1 - Predictors of cognitive outcome in ventilated early rehabilitation patients JF - Der Nervenarzt : Organ der Deutschen Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft für Neurologie N2 - Hintergrund Patienten, die nach gescheitertem Weaning von der Intensivstation in die Frührehabilitation (FR) verlegt werden, weisen neben motorischen Einschränkungen oft auch Defizite in ihrer kognitiven Leistungsfähigkeit auf. Welche patientenseitigen Faktoren das kognitive Outcome am Ende der FR beeinflussen, ist noch unzureichend untersucht. Zielstellung Ermittlung von Prädiktoren auf das kognitive Leistungsvermögen initial beatmeter FR-Patienten. Methode Zwischen 01/2014 und 12/2015 wurden 301 Patienten (68,3 ± 11,4 Jahre, 67 % männlich) einer neurologischen Phase-B-Weaningstation konsekutiv in eine prospektive Beobachtungsstudie eingeschlossen. Zur Ermittlung möglicher Einflussfaktoren auf das kognitive Outcome (operationalisiert mittels Neuromentalindex [NMI]) wurden soziodemografische Daten, kritische Erkrankung, Komorbiditäten, Parameter zu Weaning und Dekanülierung sowie diverse Scores zur Ermittlung funktionaler Parameter erhoben und mittels ANCOVA multivariat ausgewertet. Ergebnisse Insgesamt 248 Patienten (82 %) konnten erfolgreich geweant werden, 155 (52 %) dekanüliert, 75 Patienten (25 %) verstarben, davon 39 (13 %) unter Palliativtherapie. Für die überlebenden Patienten (n = 226) konnten im finalen geschlechts- und altersadjustierten statistischen Modell unabhängige Prädiktoren des NMI bei Entlassung aus der FR ermittelt werden: Wachheit und erfolgreiche Dekanülierung waren positiv mit dem NMI assoziiert, während als kritische Erkrankungen hypoxische Hirnschädigungen, Hirninfarkte und Schädel-Hirn-Traumata einen negativen Einfluss auf die kognitive Leistungsfähigkeit hatten. Das berechnete Modell begründet 57 % der Varianz des NMI (R2 = 0,568) und weist damit eine hohe Erklärungsqualität auf. Schlussfolgerung Aufgrund des erhöhten Risikos für eine verminderte kognitive Leistungsfähigkeit zum Ende der FR sollten vor allem Patienten nach Hypoxie, Hirninfarkt und Schädel-Hirn-Trauma intensiv neuropsychologisch betreut werden. Da weiterhin eine erfolgreiche Dekanülierung mit verbesserten kognitiven Leistungen assoziiert ist, sollte – vor allem bei wachen Patienten – zudem ein zügiges Trachealkanülenmanagement im therapeutischen Fokus stehen. N2 - After weaning failure, patients who are transferred from intensive care units to early rehabilitation centers (ERC) not only suffer from motor deficits but also from cognitive deficits. It is still uncertain which patient factors have an impact on cognitive outcome at the end of early rehabilitation. Investigation of predictors of cognitive performance for initially ventilated early rehabilitation patients. A total of 301 patients (mean age 68.3 +/- 11.4 years, 67% male) were consecutively enrolled in an ERC for a prospective observational study between January 2014 and December 2015. To investigate influencing factors on cognitive outcome operationalized by the neuromental index (NMI), we collected sociodemographic data, parameters about the critical illness, comorbidities, weaning and decannulation as well as different functional scores at admission and discharge and carried out multivariate analyses by ANCOVA. Of the patients 248 (82%) were successfully weaned, 155 (52%) decannulated and 75 patients (25%) died of whom 39 (13%) were under palliative treatment. For the survivors (n = 226) we could identify independent predictors of the NMI at discharge from the ERC in the final sex and age-adjusted statistical model: alertness and decannulation were positively associated with the NMI whereas hypoxia, cerebral infarction and traumatic brain injury had a negative impact on cognitive ability. The model justifies 57% of the variance of the NMI (R-2 = 0.568) and therefore has a high quality of explanation. Because of increased risk of cognitive deficits at discharge of ERC, all patients who suffered from hypoxia, cerebral infarction or traumatic brain injury should be intensively treated by neuropsychologists. Since decannulation is also associated with positive cognitive outcome, a rapid decannulation procedure should also be an important therapeutic target, especially in alert patients. KW - Early rehabilitation KW - Ventilation KW - Decannulation KW - Cognition KW - Neuromental index KW - Frührehabilitation KW - Beatmung KW - Dekanülierung KW - Kognition KW - Neuromentalindex Y1 - 0201 U6 - https://doi.org/10.1007/s00115-017-0311-5 SN - 0028-2804 SN - 1433-0407 VL - 88 SP - 905 EP - 910 PB - Springer CY - New York ER - TY - JOUR A1 - Peres, Tanara V. A1 - Eyng, Helena A1 - Lopes, Samantha C. A1 - Colle, Dirleise A1 - Goncalves, Filipe M. A1 - Venske, Debora K. R. A1 - Lopes, Mark W. A1 - Ben, Juliana A1 - Bornhorst, Julia A1 - Schwerdtle, Tanja A1 - Aschner, Michael A. A1 - Farina, Marcelo A1 - Prediger, Rui D. A1 - Leal, Rodrigo B. T1 - Developmental exposure to manganese induces lasting motor and cognitive impairment in rats JF - Neurotoxicology : the interdisciplinary journal of effects to toxic substances on the nervous system N2 - Exposure to high manganese (Mn) levels may damage the basal ganglia, leading to a syndrome analogous to Parkinson's disease, with motor and cognitive impairments. The molecular mechanisms underlying Mn neurotoxicity, particularly during development, still deserve further investigation. Herein, we addressed whether early-life Mn exposure affects motor coordination and cognitive function in adulthood and potential underlying mechanisms. Male Wistar rats were exposed intraperitoneally to saline (control) or MnCl2 (5, 10 or 20 mg/kg/day) from post-natal day (PND) 8-12. Behavioral tests were performed on PND 60-65 and biochemical analysis in the striatum and hippocampus were performed on PND14 or PND70. Rats exposed to Mn (10 and 20 mg/kg) performed significantly worse on the rotarod test than controls indicating motor coordination and balance impairments. The object and social recognition tasks were used to evaluate short-term memory. Rats exposed to the highest Mn dose failed to recognize a familiar object when replaced by a novel object as well as to recognize a familiar juvenile rat after a short period of time. However, Mn did not alter olfactory discrimination ability. In addition, Mn-treated rats displayed decreased levels of non-protein thiols (e.g. glutathione) and increased levels of glial fibrillary acidic protein (GFAP) in the striatum. Moreover, Mn significantly increased hippocampal glutathione peroxidase (GPx) activity. These findings demonstrate that acute low-level exposure to Mn during a critical neurodevelopmental period causes cognitive and motor dysfunctions that last into adulthood, that are accompanied by alterations in antioxidant defense system in both the hippocampus and striatum. (C) 2015 Elsevier Inc. All rights reserved. KW - Manganese KW - Neurotoxicity KW - Development KW - Motor coordination KW - Cognition Y1 - 2015 U6 - https://doi.org/10.1016/j.neuro.2015.07.005 SN - 0161-813X SN - 1872-9711 VL - 50 SP - 28 EP - 37 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Liu, Shuyan A1 - Schad, Daniel A1 - Kuschpel, Maxim S. A1 - Rapp, Michael Armin A1 - Heinz, Andreas T1 - Music and Video Gaming during Breaks BT - Influence on Habitual versus Goal-Directed Decision Making JF - PLoS one N2 - Different systems for habitual versus goal-directed control are thought to underlie human decision-making. Working memory is known to shape these decision-making systems and their interplay, and is known to support goal-directed decision making even under stress. Here, we investigated if and how decision systems are differentially influenced by breaks filled with diverse everyday life activities known to modulate working memory performance. We used a within-subject design where young adults listened to music and played a video game during breaks interleaved with trials of a sequential two-step Markov decision task, designed to assess habitual as well as goal-directed decision making. Based on a neurocomputational model of task performance, we observed that for individuals with a rather limited working memory capacity video gaming as compared to music reduced reliance on the goal-directed decision-making system, while a rather large working memory capacity prevented such a decline. Our findings suggest differential effects of everyday activities on key decision-making processes. KW - Decision making KW - Games KW - Working memory KW - Video games KW - Cognition KW - Cognitive impairment KW - Music cognition KW - Learning Y1 - 2016 U6 - https://doi.org/10.1371/JOURNAL.PONE.0150165 SN - 1932-6203 VL - 11 IS - 3 SP - 1 EP - 12 PB - Public Library of Science CY - Lawrence, Kan. ER - TY - GEN A1 - Liu, Shuyan A1 - Schad, Daniel A1 - Kuschpel, Maxim S. A1 - Rapp, Michael Armin A1 - Heinz, Andreas T1 - Music and Video Gaming during Breaks BT - Influence on Habitual versus Goal-Directed Decision Making N2 - Different systems for habitual versus goal-directed control are thought to underlie human decision-making. Working memory is known to shape these decision-making systems and their interplay, and is known to support goal-directed decision making even under stress. Here, we investigated if and how decision systems are differentially influenced by breaks filled with diverse everyday life activities known to modulate working memory performance. We used a within-subject design where young adults listened to music and played a video game during breaks interleaved with trials of a sequential two-step Markov decision task, designed to assess habitual as well as goal-directed decision making. Based on a neurocomputational model of task performance, we observed that for individuals with a rather limited working memory capacity video gaming as compared to music reduced reliance on the goal-directed decision-making system, while a rather large working memory capacity prevented such a decline. Our findings suggest differential effects of everyday activities on key decision-making processes. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 289 KW - Cognition KW - Cognitive impairment KW - Decision making KW - Games KW - Learning KW - Music cognition KW - Video games KW - Working memory Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-90700 SP - 1 EP - 12 ER - TY - THES A1 - Morgenstern, Ulrike T1 - Zum Zusammenhang von Motorik und Kognition bei Vorschulkindern T1 - The connection with the results of recent studies dealing with the motor skills and cognition of preschool students N2 - Problemstellung: Schuleingangsuntersuchungen belegen zunehmend Defizite in der motorischen und kognitiven Entwicklung von Einschülern. Im Hinblick auf Präventivmaßnahmen gilt dem motorischen und kognitiven Entwicklungsstand von Vorschulkindern ein verstärktes Forschungsinteresse. Die bisherige Wissensbasis soll mit aktuellen Untersuchungsergebnissen zum Zusammenhang von Motorik und Kognition bei Vorschulkindern erweitert werden. Methodik: Untersucht wurden 101 Kinder in vier Potsdamer Kitas im Alter von 3,5-4,6 Jahren. Zur Überprüfung der koordinativen und konditionellen Fähigkeiten wurden Standweitsprung, Sechs-Meter-Lauf, Balancieren, Einbeinstand und Seitliches Umsetzen sowie Handkoordination eingesetzt (KTK; Kiphard & Schilling 1972; Vogt 1978). Zusätzlich wurden in Anlehnung an das Brain-Gym-Konzept (Dennison 1984) körpermitteüberschreitende Armbewegungen qualitativ bewertet und auf Validität und Reliabilität geprüft. Die kognitiven Fähigkeiten wurden mit dem Bildbasierten Intelligenztest getestet (Schaarschmidt, Ricken, Kieschke & Preuß 2004). Ergebnisse: Jungen sind deutlich schneller und kräftiger als Mädchen, können aber geringfügig schlechter balancieren und feinkoordinieren. Ein Entwicklungssprung in den motorischen Leistungen ab dem vierten Lebensjahr konnte nachgewiesen werden. Weiterhin zeigte sich ein positiver signifikanter Zusammenhang zwischen der Gleichgewichtsfähigkeit und kognitiven Fähigkeiten bei den männlichen 3,5-Jährigen (r=.28-r=.32; p=0,01). Dies bestätigt: Je jünger die Kinder, desto stärker der Zusammenhang von Motorik und Intelligenz. Bei einseitiger Testung zeigten sich schwache signifikante Korrelationen von kognitiven Leistungen der Kinder und Qualifikation der Eltern (r=.18 - r=.21; p=0,01). Die Qualitative Bewertung der Arm- und Handbewegungen eignet sich wegen unbestätigter Validität und Reliabilität nicht als Untersuchungsmethode im Sinne einer frühfunktionellen Diagnostik. N2 - Issue: Entrance exams used to determine readiness for school of first year pupils increasingly neglect the importance of motor skills and cognitive ability developments. For the implementation of proper preventative measures, more research is necessary to assess the motor skill and cognition developments of preschool students. The children’s basic knowledge must be tested in connection with the results of recent studies dealing with the motor skills and cognition of preschool students. Procedure: 101 children between the ages of 3,5-4,6 were studied in four kindergartens in Potsdam. Their coordination and endurance abilities were examined with regards to their abilities in long jumps from standing positions, six-meter runs, balancing themselves, standing on one leg, lateral movement, and their hand co-ordinations (KTK; Kiphard & Schilling 1972; Vogt 1978). Additionally, the Brain-Gym-Concept (Dennison 1984) was evaluated vis-à-vis the children’s reliability and validity to move their arms around their middle body. The cognitive abilities were tested with a visual intelligence test (Schaarschmidt, Ricken, Kieschke & Preuß 2004). Results: Boys are clearly faster and stronger than girls. The latter however have much greater abilities in their balance and fine motor skills. It was evident that children experienced major improvements in motor skills in their fourth year. Furthermore, three and a half year old boys had a significant connection between their sense of equilibrium and cognitive abilities (r=.28-r=.32; p=0,01). This proves that the connection between motor skills and intelligence are greater the younger the children are. One sided tests showed weak correlations between the cognitive abilities of the children to those of their parents (r=.18 - r=.21; p=0,01). The qualitative assessment of arm and hand movements doesn’t deem itself eligible as a study method as its reliability and validity concerning early diagnosis hasn’t been confirmed. KW - Motorik KW - Kognition KW - Vorschulkinder KW - Motor skills KW - Cognition KW - Preschool students Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-15834 ER -