TY - JOUR A1 - Hacker, Hans-Jörg A1 - Steinberg, Pablo A1 - Bannasch, Peter T1 - Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine supplemented diet Y1 - 1998 ER - TY - JOUR A1 - Steinberg, Pablo A1 - Klingelhöffer, Alexandra A1 - Schäfer, Angelika A1 - Wüst, Günter A1 - Weiße, Günter A1 - Oesch, Franz A1 - Eigenbrodt, Erich T1 - Expression of pyruvate kinase M2 in preneoplastic hepatic foci of N-nitrosomorpholine-treated rats Y1 - 1999 ER - TY - JOUR A1 - Mazurek, Sybille A1 - Eigenbrodt, Erich A1 - Failing, Klaus A1 - Steinberg, Pablo T1 - Alterations in the glycolytic and glutaminolytic pathways after malignant transformation of rat liver oval cells Y1 - 1999 ER - TY - JOUR A1 - Steinberg, Pablo A1 - Fischer, Thomas M. A1 - Arand, Michael A1 - Park, Eunju A1 - Elmadfa, Ibrahim A1 - Rimkus, Gerhard A1 - Brunn, Hubertus A1 - Dienes, Hans-Peter T1 - Acute hepatotoxicity of the polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthaline (AHTN) Y1 - 1999 ER - TY - JOUR A1 - Bluvshtein, Evgenia A1 - Glass, George A1 - Volohonsky, Gloria A1 - Yaakubowitz, Margalit A1 - Harness, Ella A1 - Smorodinsky, Nechama A1 - Seidel, Albrecht A1 - Frank, Heinz A1 - Stark, Avishay Abraham A1 - Steinberg, Pablo T1 - Inhibition of the hydrolytic and transpeptidatic activities of rat kidney gamma-glutamyltranspeptidase by specific monoclonal antibodies Y1 - 1999 ER - TY - JOUR A1 - Schleger, C. A1 - Becker, Rolf A1 - Oesch, Franz A1 - Steinberg, Pablo T1 - The human p53 gene mutated at position 249 per se is not sufficient to immortalize human liver cells Y1 - 1999 ER - TY - JOUR A1 - Hengstler, Jan Georg A1 - VanDerBurg, Bart A1 - Steinberg, Pablo A1 - Oesch, Franz T1 - Interspecies differences in cancer susceptibility and toxicity Y1 - 1999 ER - TY - JOUR A1 - Steinberg, Pablo A1 - Fischer, Thomas M. A1 - Kiulies, Sandra A1 - Biefang, Katja A1 - Platt, Karl-Ludwig A1 - Oesch, Franz A1 - Böttger, Thomas A1 - Bulitta, Clemens A1 - Kempf, Peter A1 - Hengstler, Jan Georg T1 - Drug metabolizing capacity of cryopreserved human, rat and mouse liver parenchymal cells in suspension Y1 - 1999 ER - TY - JOUR A1 - Hengstler, Jan Georg A1 - Utesch, D. A1 - Steinberg, Pablo T1 - Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction Y1 - 2000 ER - TY - JOUR A1 - Schleger, C. A1 - Heck, R. A1 - Steinberg, Pablo T1 - The role of wild-type and mutated N-ras in the malignant transformation of liver cells Y1 - 2000 ER - TY - JOUR A1 - Hengstler, Jan Georg A1 - Ringel, M. A1 - Biefang, Katja A1 - Hammel, S. A1 - Milbert, U. A1 - Gerl, M. A1 - Klebach, M. A1 - Diener, B. A1 - Platt, Karl-Ludwig A1 - Böttger, Thomas A1 - Steinberg, Pablo A1 - Oesch, Franz T1 - Cultures with cryopreserved hepatocytes : applicability for studies of enzyme induction Y1 - 2000 ER - TY - JOUR A1 - Steinberg, Pablo A1 - Zschaler, Ingrid A1 - Thom, Elke A1 - Kuna, Manuela A1 - Wüst, Günter A1 - Schäfer-Schwebel, Angelika A1 - Müller, Rolf A1 - Kramer, Peter-Jürgen A1 - Weiße, Günter T1 - The polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthaline lacks liver tumor initiating and promoting activity in rats exposed to human-relevant doses Y1 - 2001 UR - http://www.springerlink.com/content/100462 U6 - https://doi.org/10.1007/s002040100274 SN - 0340-5761 ER - TY - JOUR A1 - Komlosh, A. A1 - Volohonsky, Gloria A1 - Porat, Noga A1 - Tuby, chen n. y. h. A1 - Bluvshtein, Evgenia A1 - Steinberg, Pablo A1 - Oesch, Franz A1 - Stark, Avishay Abraham T1 - Gamma-glutamyl transpeptidase and glutathione biosynthesis in non-tumorigenic and tumorigenic rat liver oval cell lines Y1 - 2001 ER - TY - JOUR A1 - Barlow, S. M. A1 - Greig, J. B. A1 - Bridges, J. W. A1 - Carere, A. A1 - Carpy, A. J. A1 - Galli, Corrado L. A1 - Kleiner, J. A1 - Knudsen, I. A1 - Koeter, H. B. A1 - Levy, L. S. A1 - Madsen, C. A1 - Mayer, S. A1 - Narbonne, J. F. A1 - Pfannkuch, F. A1 - Prodanchuk, M. G. A1 - Smith, Mason R. A1 - Steinberg, Pablo T1 - Hazard identification by methods of animal-based toxicology Y1 - 2002 ER - TY - JOUR A1 - Dybing, E. A1 - Doe, J. A1 - Groten, J. A1 - Kleiner, J. A1 - O'Brien, J. A1 - Renwick, A. G. A1 - Schlatter, J. A1 - Steinberg, Pablo A1 - Tritschler, A. A1 - Walker, R. A1 - Younes, M. T1 - Hazard characterisation of chemicals in food and diet : dose response, mechanisms and extrapolation issues Y1 - 2002 ER - TY - JOUR A1 - Volohonsky, Gloria A1 - Tuby, Chen N. Y. H. A1 - Porat, Noga A1 - Wellman-Rousseau, Maria A1 - Visvikis, Athanase A1 - Leroy, Pierre A1 - Rashi, Sharon A1 - Steinberg, Pablo A1 - Stark, Avishay Abraham T1 - A spectrophotometric assay of gamma-glutamylcysteine synthetase and glutathione synthetase in crude extracts from tissues and cultured mammalian cells Y1 - 2002 ER - TY - JOUR A1 - Stark, Avishay abraham A1 - Porat, Noga A1 - Volohonsky, Gloria A1 - Konlosh, A. A1 - Bluvshtein, Evgenia A1 - Tubi, C. A1 - Steinberg, Pablo T1 - The role of gamma-glutamyl transpeptidase in the biosynthesis of glutathione Y1 - 2003 ER - TY - JOUR A1 - Okano, J. A1 - Shiota, G. A1 - Matsumoto, K. A1 - Yasui, S. A1 - Kurimasa, A. A1 - Hisatome, I. A1 - Steinberg, Pablo A1 - Murawaki, Y. T1 - Hepatocyte growth factor exerts a proliferative effect on oval cells through the PI3K/AKT signaling pathway Y1 - 2003 ER - TY - JOUR A1 - Bartsch, Ingrid A1 - Zschaler, Ingrid A1 - Haseloff, Monika A1 - Steinberg, Pablo T1 - Establishment of a long-term culture system for rat colon epithelial cells N2 - The aim of this study was to establish a long-term culture. system for rat colon epithelia isolaled by incubating a 4-cm-long rat colon segment cut longitudinally with all ethylenediaminetetraacetic acid [disodium salt]- containing buffer, taken up in conditioned medium from the normal rat kidney fibroblast cell line NRK (i.e., the supernatant Of pure NRK cultures), directly plated on mitomycin C-treated NRK cells and subcultured with conditioned medium from NRK cells. Cells started to migrate out of the crypts shortly after plating them on NRK feeder layers. Some of the crypts fell apart during the isolation procedure. whereas the vast majority of them did it within I to 2 Ill after plating. The cells proliferated extremely slowly but continuously over a period of 4 mo and were epithelial because they expressed cytokeratin 19 and were stained by crystal violet at pH 2.8. In conclusion, the experimental system described ill this study allows to maintain rat colon epithelial cells for up to 4 mo in culture and can be used to Study the effects of a variety of tumor-modulating factors on growth and gene expression of normal colon epithelial cells in vitro Y1 - 2003 UR - http://www.springerlink.com/content/120498/ U6 - https://doi.org/10.1290/0404035.1 SN - 1071-2690 ER - TY - JOUR A1 - Fuchs, J. A1 - Teubner, Wera A1 - Steinberg, Pablo T1 - The resistance of intestinal epithelial cells towards the transforming activity of 2-hydroxyamino-1-methyl-6- phenylimidazo[4,5-B]pyridine is accompanied by glutathione S-transferase induction Y1 - 2004 SN - 0028-1298 ER -