TY  - JOUR
A1  - Bookers, Anke
A1  - Jacob, Louis
A1  - Bohlken, Jens
A1  - Rapp, Michael Armin
A1  - Kostev, Karel
T1  - Persistence with antipsychotics in dementia patients in Germany
JF  - International journal of clinical pharmacology and therapeutics
N2  - Background/Aims: To analyze the duration of treatment with antipsychotics in German dementia patients. Methods: This study included patients aged 60 years and over with dementia who received a first-time antipsychotic prescription by psychiatrists between 2009 and 2013. The main outcome measure was the treatment rate for more than 6 months following the index date. Results: A total of 12,979 patients with dementia (mean age 82 years, 52.1% living in nursing homes) were included. After 2 years of follow-up, 54.8%, 57.2%, 61.1%, and 65.4% of patients aged 60 - 69, 70 - 79, 80 - 89, and 90 - 99 years, respectively, received antipsychotic prescriptions. 63.9% of subjects living in nursing homes and 55.0% of subjects living at home also continued their treatment (p-value < 0.001). Conclusion: The percentage of dementia patients treated with anti psychotics is very high.
KW  - persistence
KW  - antipsychotics
KW  - dementia
Y1  - 2016
U6  - https://doi.org/10.5414/CP202631
SN  - 0946-1965
VL  - 54
SP  - 835
EP  - 840
PB  - Dustri-Verlag Dr. Karl Feistle
CY  - Deisenhofen-München
ER  - 
TY  - JOUR
A1  - Radchuk, Viktoriia
A1  - De Laender, Frederik
A1  - Cabral, Juliano Sarmento
A1  - Boulangeat, Isabelle
A1  - Crawford, Michael Scott
A1  - Bohn, Friedrich
A1  - De Raedt, Jonathan
A1  - Scherer, Cedric
A1  - Svenning, Jens-Christian
A1  - Thonicke, Kirsten
A1  - Schurr, Frank M.
A1  - Grimm, Volker
A1  - Kramer-Schadt, Stephanie
T1  - The dimensionality of stability depends on disturbance type
JF  - Ecology letters
N2  - Ecosystems respond in various ways to disturbances. Quantifying ecological stability therefore requires inspecting multiple stability properties, such as resistance, recovery, persistence and invariability. Correlations among these properties can reduce the dimensionality of stability, simplifying the study of environmental effects on ecosystems. A key question is how the kind of disturbance affects these correlations. We here investigated the effect of three disturbance types (random, species-specific, local) applied at four intensity levels, on the dimensionality of stability at the population and community level. We used previously parameterized models that represent five natural communities, varying in species richness and the number of trophic levels. We found that disturbance type but not intensity affected the dimensionality of stability and only at the population level. The dimensionality of stability also varied greatly among species and communities. Therefore, studying stability cannot be simplified to using a single metric and multi-dimensional assessments are still to be recommended.
KW  - Community model
KW  - disturbance intensity
KW  - disturbance type
KW  - extinction
KW  - individual-based model
KW  - invariability
KW  - persistence
KW  - recovery
KW  - resistance
Y1  - 2019
U6  - https://doi.org/10.1111/ele.13226
SN  - 1461-023X
SN  - 1461-0248
VL  - 22
IS  - 4
SP  - 674
EP  - 684
PB  - Wiley
CY  - Hoboken
ER  -