TY  - JOUR
A1  - Neigenfind, Jost
A1  - Grimbs, Sergio
A1  - Nikoloski, Zoran
T1  - On the relation between reactions and complexes of (bio)chemical reaction networks
JF  - Journal of theoretical biology
N2  - Robustness of biochemical systems has become one of the central questions in systems biology although it is notoriously difficult to formally capture its multifaceted nature. Maintenance of normal system function depends not only on the stoichiometry of the underlying interrelated components, but also on the multitude of kinetic parameters. Invariant flux ratios, obtained within flux coupling analysis, as well as invariant complex ratios, derived within chemical reaction network theory, can characterize robust properties of a system at steady state. However, the existing formalisms for the description of these invariants do not provide full characterization as they either only focus on the flux-centric or the concentration-centric view. Here we develop a novel mathematical framework which combines both views and thereby overcomes the limitations of the classical methodologies. Our unified framework will be helpful in analyzing biologically important system properties.
KW  - Metabolic network
KW  - Mass action system
KW  - Flux coupling analysis
KW  - Chemical reaction network theory
Y1  - 2013
U6  - https://doi.org/10.1016/j.jtbi.2012.10.016
SN  - 0022-5193
VL  - 317
IS  - 2
SP  - 359
EP  - 365
PB  - Elsevier
CY  - London
ER  -