TY  - GEN
A1  - Wippert, Pia-Maria
A1  - Wiebking, Christine
T1  - Stress and Alterations in the Pain Matrix
BT  - A Biopsychosocial Perspective on Back Pain and Its Prevention and Treatment
T2  - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
N2  - The genesis of chronic pain is explained by a biopsychosocial model. It hypothesizes an interdependency between environmental and genetic factors provoking aberrant long-term changes in biological and psychological regulatory systems. Physiological effects of psychological and physical stressors may play a crucial role in these maladaptive processes. Specifically, long-term demands on the stress response system may moderate central pain processing and influence descending serotonergic and noradrenergic signals from the brainstem, regulating nociceptive processing at the spinal level. However, the underlying mechanisms of this pathophysiological interplay still remain unclear. This paper aims to shed light on possible pathways between physical (exercise) and psychological stress and the potential neurobiological consequences in the genesis and treatment of chronic pain, highlighting evolving concepts and promising research directions in the treatment of chronic pain. Two treatment forms (exercise and mindfulness-based stress reduction as exemplary therapies), their interaction, and the dose-response will be discussed in more detail, which might pave the way to a better understanding of alterations in the pain matrix and help to develop future prevention and therapeutic concepts
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 438 
KW  - stress
KW  - allostatic load
KW  - relaxation
KW  - back pain
KW  - chronic pain
KW  - physical activity
KW  - exercise
KW  - neuroplasticity
KW  - pain matrix
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-412058
IS  - 438
ER  -