TY - JOUR A1 - Maares, Maria A1 - Keil, Claudia A1 - Koza, Jenny A1 - Straubing, Sophia A1 - Schwerdtle, Tanja A1 - Haase, Hajo T1 - In Vitro Studies on Zinc Binding and Buffering by Intestinal Mucins JF - International Journal of Molecular Sciences N2 - The investigation of luminal factors influencing zinc availability and accessibility in the intestine is of great interest when analyzing parameters regulating intestinal zinc resorption. Of note, intestinal mucins were suggested to play a beneficial role in the luminal availability of zinc. Their exact zinc binding properties, however, remain unknown and the impact of these glycoproteins on human intestinal zinc resorption has not been investigated in detail. Thus, the aim of this study is to elucidate the impact of intestinal mucins on luminal uptake of zinc into enterocytes and its transfer into the blood. In the present study, in vitro zinc binding properties of mucins were analyzed using commercially available porcine mucins and secreted mucins of the goblet cell line HT-29-MTX. The molecular zinc binding capacity and average zinc binding affinity of these glycoproteins demonstrates that mucins contain multiple zinc-binding sites with biologically relevant affinity within one mucin molecule. Zinc uptake into the enterocyte cell line Caco-2 was impaired by zinc-depleted mucins. Yet this does not represent their form in the intestinal lumen in vivo under zinc adequate conditions. In fact, zinc-uptake studies into enterocytes in the presence of mucins with differing degree of zinc saturation revealed zinc buffering by these glycoproteins, indicating that mucin-bound zinc is still available for the cells. Finally, the impact of mucins on zinc resorption using three-dimensional cultures was studied comparing the zinc transfer of a Caco-2/HT-29-MTX co-culture and conventional Caco-2 monoculture. Here, the mucin secreting co-cultures yielded higher fractional zinc resorption and elevated zinc transport rates, suggesting that intestinal mucins facilitate the zinc uptake into enterocytes and act as a zinc delivery system for the intestinal epithelium. KW - intestinal zinc resorption KW - zinc binding KW - mucus layer KW - intestinal mucins KW - in vitro intestinal model KW - goblet cells KW - Caco-2/HT-29-MTX-model Y1 - 2018 U6 - https://doi.org/10.3390/ijms19092662 SN - 1422-0067 VL - 19 IS - 9 ER - TY - JOUR A1 - Nitze, Ingmar A1 - Grosse, Guido A1 - Jones, Benjamin M. A1 - Romanovsky, Vladimir E. A1 - Boike, Julia T1 - Remote sensing quantifies widespread abundance of permafrost region disturbances across the Arctic and Subarctic JF - Nature Communications N2 - Local observations indicate that climate change and shifting disturbance regimes are causing permafrost degradation. However, the occurrence and distribution of permafrost region disturbances (PRDs) remain poorly resolved across the Arctic and Subarctic. Here we quantify the abundance and distribution of three primary PRDs using time-series analysis of 30-m resolution Landsat imagery from 1999 to 2014. Our dataset spans four continental-scale transects in North America and Eurasia, covering similar to 10% of the permafrost region. Lake area loss (-1.45%) dominated the study domain with enhanced losses occurring at the boundary between discontinuous and continuous permafrost regions. Fires were the most extensive PRD across boreal regions (6.59%), but in tundra regions (0.63%) limited to Alaska. Retrogressive thaw slumps were abundant but highly localized (< 10(-5)%). Our analysis synergizes the global-scale importance of PRDs. The findings highlight the need to include PRDs in next-generation land surface models to project the permafrost carbon feedback. Y1 - 2018 U6 - https://doi.org/10.1038/s41467-018-07663-3 SN - 2041-1723 VL - 9 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Kath, Nadja J. A1 - Boit, Alice A1 - Guill, Christian A1 - Gaedke, Ursula T1 - Accounting for activity respiration results in realistic trophic transfer efficiencies in allometric trophic network (ATN) models JF - Theoretical ecology N2 - Allometric trophic network (ATN) models offer high flexibility and scalability while minimizing the number of parameters and have been successfully applied to investigate complex food web dynamics and their influence on food web diversity and stability. However, the realism of ATN model energetics has never been assessed in detail, despite their critical influence on dynamic biomass and production patterns. Here, we compare the energetics of the currently established original ATN model, considering only biomass-dependent basal respiration, to an extended ATN model version, considering both basal and assimilation-dependent activity respiration. The latter is crucial in particular for unicellular and invertebrate organisms which dominate the metabolism of pelagic and soil food webs. Based on metabolic scaling laws, we show that the extended ATN version reflects the energy transfer through a chain of four trophic levels of unicellular and invertebrate organisms more realistically than the original ATN version. Depending on the strength of top-down control, the original ATN model yields trophic transfer efficiencies up to 71% at either the third or the fourth trophic level, which considerably exceeds any realistic values. In contrast, the extended ATN version yields realistic trophic transfer efficiencies 30% at all trophic levels, in accordance with both physiological considerations and empirical evidence from pelagic systems. Our results imply that accounting for activity respiration is essential for consistently implementing the metabolic theory of ecology in ATN models and for improving their quantitative predictions, which makes them more powerful tools for investigating the dynamics of complex natural communities. KW - Food web KW - Trophic transfer efficiency KW - Allometric trophic network model KW - Allometry KW - Energy transfer KW - Activity respiration Y1 - 2018 U6 - https://doi.org/10.1007/s12080-018-0378-z SN - 1874-1738 SN - 1874-1746 VL - 11 IS - 4 SP - 453 EP - 463 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Demir-Walther, Meltem T1 - Die Entwicklung eines Unterrichtskonzeptes zur Förderung von Sachlernen und Lesekompetenz aus inklusionsdidaktischer Sicht BT - ein Unterricht für Kinder mit und ohne Down-Syndrom JF - Sachunterrichtsdidaktik & Inklusion : ein Beitrag zur Entwicklung Y1 - 2018 SN - 978-3-8340-1829-8 SP - 39 EP - 44 PB - Schneider Verlag Hohengehren GmbH CY - Baltmannsweiler ER - TY - JOUR A1 - Walther, Sophia A1 - Guanter, Luis A1 - Heim, Birgit A1 - Jung, Martin A1 - Duveiller, Gregory A1 - Wolanin, Aleksandra A1 - Sachs, Torsten T1 - Assessing the dynamics of vegetation productivity in circumpolar regions with different satellite indicators of greenness and photosynthesis JF - Biogeosciences N2 - High-latitude treeless ecosystems represent spatially highly heterogeneous landscapes with small net carbon fluxes and a short growing season. Reliable observations and process understanding are critical for projections of the carbon balance of the climate-sensitive tundra. Space-borne remote sensing is the only tool to obtain spatially continuous and temporally resolved information on vegetation greenness and activity in remote circumpolar areas. However, confounding effects from persistent clouds, low sun elevation angles, numerous lakes, widespread surface inundation, and the sparseness of the vegetation render it highly challenging. Here, we conduct an extensive analysis of the timing of peak vegetation productivity as shown by satellite observations of complementary indicators of plant greenness and photosynthesis. We choose to focus on productivity during the peak of the growing season, as it importantly affects the total annual carbon uptake. The suite of indicators are as follows: (1) MODIS-based vegetation indices (VIs) as proxies for the fraction of incident photosynthetically active radiation (PAR) that is absorbed (fPAR), (2) VIs combined with estimates of PAR as a proxy of the total absorbed radiation (APAR), (3) sun-induced chlorophyll fluorescence (SIF) serving as a proxy for photosynthesis, (4) vegetation optical depth (VOD), indicative of total water content and (5) empirically upscaled modelled gross primary productivity (GPP). Averaged over the pan-Arctic we find a clear order of the annual peak as APAR <= GPP < SIF < VIs/VOD. SIF as an indicator of photosynthesis is maximised around the time of highest annual temperatures. The modelled GPP peaks at a similar time to APAR. The time lag of the annual peak between APAR and instantaneous SIF fluxes indicates that the SIF data do contain information on light-use efficiency of tundra vegetation, but further detailed studies are necessary to verify this. Delayed peak greenness compared to peak photosynthesis is consistently found across years and land-cover classes. A particularly late peak of the normalised difference vegetation index (NDVI) in regions with very small seasonality in greenness and a high amount of lakes probably originates from artefacts. Given the very short growing season in circumpolar areas, the average time difference in maximum annual photosynthetic activity and greenness or growth of 3 to 25 days (depending on the data sets chosen) is important and needs to be considered when using satellite observations as drivers in vegetation models. Y1 - 2018 U6 - https://doi.org/10.5194/bg-15-6221-2018 SN - 1726-4170 SN - 1726-4189 VL - 15 IS - 20 SP - 6221 EP - 6256 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Schaal, Frederik A1 - Rutloh, Michael A1 - Weidenfeld, Susanne A1 - Stumpe, Joachim A1 - Michler, Peter A1 - Pruss, Christof A1 - Osten, Wolfgang T1 - Optically addressed modulator for tunable spatial polarization control JF - Optics express : the international electronic journal of optics N2 - We present an optically addressed non-pixelated spatial light modulator. The system is based on reversible photoalignment of a LC cell using a red light sensitive novel azobenzene photoalignment layer. It is an electrode-free device that manipulates the liquid crystal orientation and consequently the polarization via light without artifacts caused by electrodes. The capability to miniaturize the spatial light modulator allows the integration into a microscope objective. This includes a miniaturized 200 channel optical addressing system based on a VCSEL array and hybrid refractive-diffractive beam shapers. As an application example, the utilization as a microscope objective integrated analog phase contrast modulator is shown. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement Y1 - 2018 U6 - https://doi.org/10.1364/OE.26.028119 SN - 1094-4087 VL - 26 IS - 21 SP - 28119 EP - 28130 PB - Optical Society of America CY - Washington ER - TY - JOUR A1 - Peng, Junjie A1 - Liu, Danxu A1 - Wang, Yingtao A1 - Zeng, Ying A1 - Cheng, Feng A1 - Zhang, Wenqiang T1 - Weight-based strategy for an I/O-intensive application at a cloud data center JF - Concurrency and computation : practice & experience N2 - Applications with different characteristics in the cloud may have different resources preferences. However, traditional resource allocation and scheduling strategies rarely take into account the characteristics of applications. Considering that an I/O-intensive application is a typical type of application and that frequent I/O accesses, especially small files randomly accessing the disk, may lead to an inefficient use of resources and reduce the quality of service (QoS) of applications, a weight allocation strategy is proposed based on the available resources that a physical server can provide as well as the characteristics of the applications. Using the weight obtained, a resource allocation and scheduling strategy is presented based on the specific application characteristics in the data center. Extensive experiments show that the strategy is correct and can guarantee a high concurrency of I/O per second (IOPS) in a cloud data center with high QoS. Additionally, the strategy can efficiently improve the utilization of the disk and resources of the data center without affecting the service quality of applications. KW - IOPS KW - process scheduling KW - random I KW - O KW - small files KW - weight Y1 - 2018 U6 - https://doi.org/10.1002/cpe.4648 SN - 1532-0626 SN - 1532-0634 VL - 30 IS - 19 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Traxler, Juliane A1 - Hanssen, Marjolein M. A1 - Lautenbacher, Stefan A1 - Ottawa, Fabian A1 - Peters, Madelon L. T1 - General versus pain-specific cognitions BT - Pain catastrophizing but not optimism influences conditioned pain modulation JF - European journal of pain N2 - Background Previous studies found evidence that dispositional optimism is related to lower pain sensitivity. Recent findings suggest that temporarily increasing optimism by means of imagining a positive future may also have pain-alleviating effects. Objectives The present experiment was designed to investigate conditioned pain modulation (CPM) as a potential underlying mechanism of this pain-alleviating effect of induced optimism. Methods For this purpose, 45 healthy participants were randomized into an optimistic or neutral imagery condition. Additionally, participants completed questionnaires on dispositional optimism, pain catastrophizing and pain expectations. CPM was assessed by delivering a series of five heat pain stimuli on the nondominant hand before and during immersion of the dominant hand in water of 5 degrees C for 70 s. Results A clear CPM effect was found, that is heat pain reports were lower during simultaneous cold water stimulation. Although the optimism manipulation successfully increased optimism, it did not affect pain ratings or CPM. Post hoc analyses indicated that dispositional optimism was not associated with the magnitude of CPM, but pain catastrophizing and pain expectations did significantly correlate with the CPM effect. Conclusion Pain-specific but not general cognitions appear to influence endogenous pain modulation. Significance Conditioned pain modulation is not the underlying mechanism of the pain-alleviating effects of induced optimism. However, pain-specific cognitions including pain catastrophizing and pain expectations affect endogenous pain modulation which should be taken into account in treatment and CPM research. Y1 - 2018 U6 - https://doi.org/10.1002/ejp.1294 SN - 1090-3801 SN - 1532-2149 VL - 23 IS - 1 SP - 150 EP - 159 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Maes, Sybryn L. A1 - Perring, Michael P. A1 - Vanhellemont, Margot A1 - Depauw, Leen A1 - Van den Bulcke, Jan A1 - Brumelis, Guntis A1 - Brunet, Jorg A1 - Decocq, Guillaume A1 - den Ouden, Jan A1 - Härdtle, Werner A1 - Hedl, Radim A1 - Heinken, Thilo A1 - Heinrichs, Steffi A1 - Jaroszewicz, Bogdan A1 - Kopecký, Martin A1 - Malis, Frantisek A1 - Wulf, Monika A1 - Verheyen, Kris T1 - Environmental drivers interactively affect individual tree growth across temperate European forests JF - Global change biology N2 - Forecasting the growth of tree species to future environmental changes requires abetter understanding of its determinants. Tree growth is known to respond to global‐change drivers such as climate change or atmospheric deposition, as well as to localland‐use drivers such as forest management. Yet, large geographical scale studiesexamining interactive growth responses to multiple global‐change drivers are relativelyscarce and rarely consider management effects. Here, we assessed the interactiveeffects of three global‐change drivers (temperature, precipitation and nitrogen deposi-tion) on individual tree growth of three study species (Quercus robur/petraea, Fagus syl-vatica and Fraxinus excelsior). We sampled trees along spatial environmental gradientsacross Europe and accounted for the effects of management for Quercus. We collectedincrement cores from 267 trees distributed over 151 plots in 19 forest regions andcharacterized their neighbouring environment to take into account potentially confounding factors such as tree size, competition, soil conditions and elevation. Wedemonstrate that growth responds interactively to global‐change drivers, with species ‐specific sensitivities to the combined factors. Simultaneously high levels of precipita-tion and deposition benefited Fraxinus, but negatively affected Quercus’ growth, high-lighting species‐specific interactive tree growth responses to combined drivers. ForFagus, a stronger growth response to higher temperatures was found when precipita-tion was also higher, illustrating the potential negative effects of drought stress underwarming for this species. Furthermore, we show that past forest management canmodulate the effects of changing temperatures on Quercus’ growth; individuals in plotswith a coppicing history showed stronger growth responses to higher temperatures.Overall, our findings highlight how tree growth can be interactively determined by glo-bal‐change drivers, and how these growth responses might be modulated by past for-est management. By showing future growth changes for scenarios of environmentalchange, we stress the importance of considering multiple drivers, including past man-agement and their interactions, when predicting tree growth. KW - basal area increment KW - climate change KW - Fagus KW - Fraxinus KW - historical ecology KW - nitrogen deposition KW - Quercus KW - tree-ring analysis Y1 - 2018 U6 - https://doi.org/10.1111/gcb.14493 SN - 1354-1013 SN - 1365-2486 VL - 25 IS - 1 SP - 201 EP - 217 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Fiedler, Bernhard A1 - Hainzl, Sebastian A1 - Zöller, Gert A1 - Holschneider, Matthias T1 - Detection of Gutenberg-Richter b-Value Changes in Earthquake Time Series JF - Bulletin of the Seismological Society of America N2 - The Gutenberg-Richter relation for earthquake magnitudes is the most famous empirical law in seismology. It states that the frequency of earthquake magnitudes follows an exponential distribution; this has been found to be a robust feature of seismicity above the completeness magnitude, and it is independent of whether global, regional, or local seismicity is analyzed. However, the exponent b of the distribution varies significantly in space and time, which is important for process understanding and seismic hazard assessment; this is particularly true because of the fact that the Gutenberg-Richter b-value acts as a proxy for the stress state and quantifies the ratio of large-to-small earthquakes. In our work, we focus on the automatic detection of statistically significant temporal changes of the b-value in seismicity data. In our approach, we use Bayes factors for model selection and estimate multiple change-points of the frequency-magnitude distribution in time. The method is first applied to synthetic data, showing its capability to detect change-points as function of the size of the sample and the b-value contrast. Finally, we apply this approach to examples of observational data sets for which b-value changes have previously been stated. Our analysis of foreshock and after-shock sequences related to mainshocks, as well as earthquake swarms, shows that only a portion of the b-value changes is statistically significant. Y1 - 2018 U6 - https://doi.org/10.1785/0120180091 SN - 0037-1106 SN - 1943-3573 VL - 108 IS - 5A SP - 2778 EP - 2787 PB - Seismological Society of America CY - Albany ER - TY - JOUR A1 - Verch, Ronald A1 - Hirschmüller, Anja A1 - Müller, Juliane A1 - Baur, Heiner A1 - Mayer, Frank A1 - Müller, Steffen T1 - Is in-toing gait physiological in children? BT - Results of a large cohort study in 5910 healthy (pre-) school children JF - Gait & posture N2 - Research question: This study aimed to establish reference values in 1-14 year old healthy children and to implement FPA-percentile curves for daily clinical use. Methods: 5910 healthy children performed at least 3 repetitions of barefoot walking over an instrumented walkway using a pressure measurement platform. The FPA [degrees] was extracted and analyzed by age and gender (mean +/- standard deviation; median with percentiles, MANOVA (age, gender) and Wilcoxon-Signed-Rank test for intra-individual side differences (alpha = 0.05). Results: FPA maximum was observed in 2-year-old children and diminished significant until the age of 4 to moderate out-toeing. For ages 5-14, no statistically significant differences in FPA values were present (p > 0.05). MANOVA confirmed age (p < 0.001) and gender (p < 0.001) as significant FPA influencing factors, without combined effect (p > 0.05). In every age group, right feet showed significantly greater out-toeing (p < 0.05). Significance: Percentile values indicate a wide FPA range in children. FPA development in young children shows a spontaneous shift towards moderate external rotation (age 2-4), whereby in-toeing <= 1-5 degrees can be present, but can return to normal. Bilateral in-toeing after the age of four and unilateral in-toeing after the age of seven should be monitored. KW - Foot progression angle KW - Children KW - In-toeing KW - Out-toeing KW - Gait Y1 - 2018 U6 - https://doi.org/10.1016/j.gaitpost.2018.08.019 SN - 0966-6362 SN - 1879-2219 VL - 66 SP - 70 EP - 75 PB - Elsevier CY - Clare ER - TY - JOUR A1 - Tape, Ken D. A1 - Jones, Benjamin M. A1 - Arp, Christopher D. A1 - Nitze, Ingmar A1 - Grosse, Guido T1 - Tundra be dammed BT - beaver colonization of the arctic JF - Global change biology N2 - Increasing air temperatures are changing the arctic tundra biome. Permafrost is thawing, snow duration is decreasing, shrub vegetation is proliferating, and boreal wildlife is encroaching. Here we present evidence of the recent range expansion of North American beaver (Castor canadensis) into the Arctic, and consider how this ecosystem engineer might reshape the landscape, biodiversity, and ecosystem processes. We developed a remote sensing approach that maps formation and disappearance of ponds associated with beaver activity. Since 1999, 56 new beaver pond complexes were identified, indicating that beavers are colonizing a predominantly tundra region (18,293km(2)) of northwest Alaska. It is unclear how improved tundra stream habitat, population rebound following overtrapping for furs, or other factors are contributing to beaver range expansion. We discuss rates and likely routes of tundra beaver colonization, as well as effects on permafrost, stream ice regimes, and freshwater and riparian habitat. Beaver ponds and associated hydrologic changes are thawing permafrost. Pond formation increases winter water temperatures in the pond and downstream, likely creating new and more varied aquatic habitat, but specific biological implications are unknown. Beavers create dynamic wetlands and are agents of disturbance that may enhance ecosystem responses to warming in the Arctic. KW - arctic tundra KW - beaver KW - climate change KW - permafrost KW - population recovery KW - salmon KW - shrub expansion KW - stream Y1 - 2018 U6 - https://doi.org/10.1111/gcb.14332 SN - 1354-1013 SN - 1365-2486 VL - 24 IS - 10 SP - 4478 EP - 4488 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Koehler, Friedrich A1 - Koehler, Kerstin A1 - Deckwart, Oliver A1 - Prescher, Sandra A1 - Wegscheider, Karl A1 - Winkler, Sebastian A1 - Vettorazzi, Eik A1 - Polze, Andreas A1 - Stangl, Karl A1 - Hartmann, Oliver A1 - Marx, Almuth A1 - Neuhaus, Petra A1 - Scherf, Michael A1 - Kirwan, Bridget-Anne A1 - Anker, Stefan D. T1 - Telemedical Interventional Management in Heart Failure II (TIM-HF2), a randomised, controlled trial investigating the impact of telemedicine on unplanned cardiovascular hospitalisations and mortality in heart failure patients BT - study design and description of the intervention JF - European Journal of Heart Failure N2 - Background Heart failure (HF) is a complex, chronic condition that is associated with debilitating symptoms, all of which necessitate close follow-up by health care providers. Lack of disease monitoring may result in increased mortality and more frequent hospital readmissions for decompensated HF. Remote patient management (RPM) in this patient population may help to detect early signs and symptoms of cardiac decompensation, thus enabling a prompt initiation of the appropriate treatment and care before a manifestation of HF decompensation. Objective The objective of the present article is to describe the design of a new trial investigating the impact of RPM on unplanned cardiovascular hospitalisations and mortality in HF patients. Methods The TIM-HF2 trial is designed as a prospective, randomised, controlled, parallel group, open (with randomisation concealment), multicentre trial with pragmatic elements introduced for data collection. Eligible patients with HF are randomised (1:1) to either RPM + usual care or to usual care only and are followed for 12 months. The primary outcome is the percentage of days lost due to unplanned cardiovascular hospitalisations or all-cause death. The main secondary outcomes are all-cause and cardiovascular mortality. Conclusion The TIM-HF2 trial will provide important prospective data on the potential beneficial effect of telemedical monitoring and RPM on unplanned cardiovascular hospitalisations and mortality in HF patients. KW - Chronic heart failure KW - Telemonitoring KW - Remote patient management KW - Hospitalisation Y1 - 2018 U6 - https://doi.org/10.1002/ejhf.1300 SN - 1388-9842 SN - 1879-0844 VL - 20 IS - 10 SP - 1485 EP - 1493 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Franco-Obregon, Alfredo A1 - Cambria, Elena A1 - Greutert, Helen A1 - Wernas, Timon A1 - Hitzl, Wolfgang A1 - Egli, Marcel A1 - Sekiguchi, Miho A1 - Boos, Norbert A1 - Hausmann, Oliver A1 - Ferguson, Stephen J. A1 - Kobayashi, Hiroshi A1 - Würtz-Kozak, Karin T1 - TRPC6 in simulated microgravity of intervertebral disc cells JF - European Spine Journal N2 - Purpose Prolonged bed rest and microgravity in space cause intervertebral disc (IVD) degeneration. However, the underlying molecular mechanisms are not completely understood. Transient receptor potential canonical (TRPC) channels are implicated in mechanosensing of several tissues, but are poorly explored in IVDs. Methods Primary human IVD cells from surgical biopsies composed of both annulus fibrosus and nucleus pulposus (passage 1-2) were exposed to simulated microgravity and to the TRPC channel inhibitor SKF-96365 (SKF) for up to 5days. Proliferative capacity, cell cycle distribution, senescence and TRPC channel expression were analyzed. Results Both simulated microgravity and TRPC channel antagonism reduced the proliferative capacity of IVD cells and induced senescence. While significant changes in cell cycle distributions (reduction in G1 and accumulation in G2/M) were observed upon SKF treatment, the effect was small upon 3days of simulated microgravity. Finally, downregulation of TRPC6 was shown under simulated microgravity. Conclusions Simulated microgravity and TRPC channel inhibition both led to reduced proliferation and increased senescence. Furthermore, simulated microgravity reduced TRPC6 expression. IVD cell senescence and mechanotransduction may hence potentially be regulated by TRPC6 expression. This study thus reveals promising targets for future studies. KW - Intervertebral disc KW - Simulated microgravity KW - Senescence KW - TRP channels KW - Mechanotransduction KW - Gene expression Y1 - 2018 U6 - https://doi.org/10.1007/s00586-018-5688-8 SN - 0940-6719 SN - 1432-0932 VL - 27 IS - 10 SP - 2621 EP - 2630 PB - Springer CY - New York ER - TY - JOUR A1 - Hoffmann, Svenja Sarah Helen A1 - Cortes-Garcia, Laura A1 - Warschburger, Petra T1 - Weight/shape and muscularity concerns and emotional problems in adolescent boys and girls BT - A cross-lagged panel analysis JF - Journal of adolescence N2 - Introduction: The goal of the present study was to identify the prospective relations between weight/shape and muscularity concerns and emotional problems in adolescents. Methods: Self-report data of 966 German male and female adolescents were analyzed in a cross lagged panel design. Results: Analyses of latent means revealed significant correlations between weight/shape concern and emotional problems as well as between muscularity concern and emotional problems in both genders. Moreover, weight/shape concern predicted emotional problems prospectively, but only in girls. Regarding muscularity concern, we could not find any prospective relation with emotional problems In boys or girls from the general population. Conclusions: It is assumed that as appearance is highly relevant for the self-concept in girls, concerns about the look might promote emotional problems. Thus, weight/shape concern should be addressed in the prevention of emotional problems in adolescent girls, whereas further research is necessary investigating the contribution of muscularity concern in this context. KW - Weight/shape concern KW - Muscularity concern KW - Depressive symptoms KW - Adolescents KW - Cross-lagged panel analysis Y1 - 2018 U6 - https://doi.org/10.1016/j.adolescence.2018.07.005 SN - 0140-1971 SN - 1095-9254 VL - 68 SP - 70 EP - 77 PB - Elsevier CY - London ER - TY - JOUR A1 - Emberson, Robert A1 - Galy, Albert A1 - Hovius, Niels T1 - Weathering of Reactive Mineral Phases in Landslides Acts as a Source of Carbon Dioxide in Mountain Belts JF - Journal of geophysical research : Earth surface N2 - Bedrock landsliding in mountain belts can elevate overall chemical weathering rates through rapid dissolution of exhumed reactive mineral phases in transiently stored deposits. This link between a key process of erosion and the resultant weathering affects the sequestering of carbon dioxide through weathering of silicate minerals and broader links between erosion in active orogens and climate change. Here we address the effect on the carbon cycle of weathering induced by bedrock landsliding in Taiwan and the Western Southern Alps of New Zealand. Using solute chemistry data from samples of seepage from landslide deposits and river discharge from catchments with variable proportions of landsliding, we model the proportion of silicate and carbonate weathering and the balance of sulfuric and carbonic acids that act as weathering agents. We correct for secondary precipitation, geothermal, and cyclic input, to find a closer approximation of the weathering explicitly occurring within landslide deposits. We find highly variable proportions of sulfuric and carbonic acids driving weathering in landslides and stable hillslopes. Despite this variability, the predominance of rapid carbonate weathering within landslides and catchments where mass wasting is prevalent results at best in limited sequestration of carbon dioxide by this process of rapid erosion. In many cases where sulfuric acid is a key weathering agent, a net release of CO2 to the atmosphere occurs. This suggests that a causal link between erosion in mountain belts and climate change through the sequestration of CO2, if it exists, must operate through a process other than chemical weathering driven by landsliding. Plain Language Summary There is a long-standing debate surrounding the link between erosion and climate. It is often suggested that as temperatures increase, rainier and stormier weather could increase erosion of rock; as that rock is exposed, silicate minerals within could break down, which, on long time scales, can remove CO2 from the atmosphere, lowering global temperatures and acting as a negative feedback. Recent studies have shown that landslide deposits are key locations for the link between chemical weathering and physical erosion in some mountain belts. To test how landslides affect the erosion-climate link, we used samples of water seeping through landslides in Taiwan and New Zealand to calculate the amount of carbon dioxide that is either absorbed or released through this chemical reaction. We find that the large amount of freshly exposed rock in Taiwanese landslide deposits contains significant carbonate rock and sulfide minerals; the net result of the weathering of these minerals is a release of carbon dioxide, which inverts the traditional perspective on the role erosion plays in controlling carbon dioxide release. In some mountain belts, it seems that increased erosion and resulting landsliding may act to increase carbon dioxide in the air, opening further questions into the nature of erosional-climatic links. KW - chemical weathering KW - landslides KW - erosion-climate link KW - carbon dioxide Y1 - 2018 U6 - https://doi.org/10.1029/2018JF004672 SN - 2169-9003 SN - 2169-9011 VL - 123 IS - 10 SP - 2695 EP - 2713 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Murray, Kendra E. A1 - Braun, Jean A1 - Reiners, Peter W. T1 - Toward Robust Interpretation of Low-Temperature Thermochronometers in Magmatic Terranes JF - Geochemistry, geophysics, geosystems N2 - Many regions central to our understanding of tectonics and landscape evolution are active or ancient magmatic terranes, and robust interpretation of low-temperature thermochronologic ages in these settings requires careful attention to the drivers of rock heating and cooling, including magmatism. However, we currently lack a quantitative framework for evaluating the potential role of magmatic coolingthat is, post-magmatic thermal relaxationin shaping cooling age patterns in regions with a history of intrusive magmatism. Here we use analytical approximations and numerical models to characterize how low-temperature thermochronometers document cooling inside and around plutons in steadily exhuming environments. Our models predict that the thermal field a pluton intrudes into, specifically the ambient temperatures relative to the closure temperature of a given thermochronometer, is as important as the pluton size and temperature in controlling the pattern and extent of thermochronometer resetting in the country rocks around a pluton. We identify one advective and several conductive timescales that govern the relationship between the crystallization and cooling ages inside a pluton. In synthetic vertical age-elevation relationships (AERs), resetting next to plutons results in changes in AER slope that could be misinterpreted as past changes in exhumation rate if the history of magmatism is not accounted for. Finally, we find that large midcrustal plutons, such as those emplaced at similar to 10-15-km depth, can reset the low-temperature thermochronometers far above them in the upper crusta result with considerable consequences for thermochronology in arcs and regions with a history of magmatic activity that may not have a surface expression. KW - He thermochronology KW - Peclet number KW - age-elevation relationships Y1 - 2018 U6 - https://doi.org/10.1029/2018GC007595 SN - 1525-2027 VL - 19 IS - 10 SP - 3739 EP - 3763 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Schmälzlin, Elmar Gerd A1 - Moralejo, Benito A1 - Gersonde, Ingo A1 - Schleusener, Johannes A1 - Darvin, Maxim E. A1 - Thiede, Gisela A1 - Roth, Martin M. T1 - Nonscanning large-area Raman imaging for ex vivo/in vivo skin cancer discrimination JF - Journal of biomedical optics N2 - Imaging Raman spectroscopy can be used to identify cancerous tissue. Traditionally, a step-by-step scanning of the sample is applied to generate a Raman image, which, however, is too slow for routine examination of patients. By transferring the technique of integral field spectroscopy (IFS) from astronomy to Raman imaging, it becomes possible to record entire Raman images quickly within a single exposure, without the need for a tedious scanning procedure. An IFS-based Raman imaging setup is presented, which is capable of measuring skin ex vivo or in vivo. It is demonstrated how Raman images of healthy and cancerous skin biopsies were recorded and analyzed. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. KW - Raman spectroscopy KW - cancer diagnosis KW - Raman imaging KW - multichannel KW - astronomy KW - epidermis KW - dermis Y1 - 2018 U6 - https://doi.org/10.1117/1.JBO.23.10.105001 SN - 1083-3668 SN - 1560-2281 VL - 23 IS - 10 PB - SPIE CY - Bellingham ER - TY - JOUR A1 - Mann, Michael E. A1 - Rahmstorf, Stefan A1 - Kornhuber, Kai A1 - Steinman, Byron A. A1 - Miller, Sonya K. A1 - Petri, Stefan A1 - Coumou, Dim T1 - Projected changes in persistent extreme summer weather events BT - The role of quasi-resonant amplification JF - Science Advances N2 - Persistent episodes of extreme weather in the Northern Hemisphere summer have been associated with high-amplitude quasi-stationary atmospheric Rossby waves, with zonal wave numbers 6 to 8 resulting from the phenomenon of quasi-resonant amplification (QRA). A fingerprint for the occurrence of QRA can be defined in terms of the zonally averaged surface temperature field. Examining state-of-the-art [Coupled Model Intercomparison Project Phase 5 (CMIP5)] climate model projections, we find that QRA events are likely to increase by similar to 50% this century under business-as-usual carbon emissions, but there is considerable variation among climate models. Some predict a near tripling of QRA events by the end of the century, while others predict a potential decrease. Models with amplified Arctic warming yield the most pronounced increase in QRA events. The projections are strongly dependent on assumptions regarding the nature of changes in radiative forcing associated with anthropogenic aerosols over the next century. One implication of our findings is that a reduction in midlatitude aerosol loading could actually lead to Arctic de-amplification this century, ameliorating potential increases in persistent extreme weather events. Y1 - 2018 U6 - https://doi.org/10.1126/sciadv.aat3272 SN - 2375-2548 VL - 4 IS - 10 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Wathelet, Marc A1 - Guillier, B. A1 - Roux, P. A1 - Cornou, C. A1 - Ohrnberger, Matthias T1 - Rayleigh wave three-component beamforming BT - signed ellipticity assessment from high-resolution frequency-wavenumber processing of ambient vibration arrays JF - Geophysical journal international N2 - The variation of Rayleigh ellipticity versus frequency is gaining popularity in site characterization. It becomes a necessary observable to complement dispersion curves when inverting shear wave velocity profiles. Various methods have been proposed so far to extract polarization from ambient vibrations recorded on a single three-component station or with an array of three-component sensors. If only absolute values were recovered 10 yr ago, new array-based techniques were recently proposed with enhanced efficiencies providing also the ellipticity sign. With array processing, higher-order modes are often detected even in the ellipticity domain. We suggest to explore the properties of a high-resolution beamforming where radial and vertical components are explicitly included. If N is the number of three-component sensors, 2N x 2N cross-spectral density matrices are calculated for all presumed directions of propagation. They are built with N radial and N vertical channels. As a first approach, steering vectors are designed to fit with Rayleigh wave properties: the phase shift between radial and vertical components is either -Pi/2 or Pi/2. We show that neglecting the ellipticity tilt due to attenuation has only minor effects on the results. Additionally, we prove analytically that it is possible to retrieve the ellipticity value from the usual maximization of the high-resolution beam power. The method is tested on synthetic data sets and on experimental data. Both are reference sites already analysed by several authors. A detailed comparison with previous results on these cases is provided. KW - Fourier analysis KW - Time-series analysis KW - Site effects KW - Surface waves and free oscillations KW - Wave propagation Y1 - 2018 U6 - https://doi.org/10.1093/gji/ggy286 SN - 0956-540X SN - 1365-246X VL - 215 IS - 1 SP - 507 EP - 523 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Wenger, Marina A1 - Lüdtke, Oliver A1 - Brunner, Martin T1 - Übereinstimmung, Variabilität und Reliabilität von Schülerurteilen zur Unterrichtsqualität auf Schulebene T1 - Interrater agreement, variability and reliability of student ratings of instructional quality at the school-level BT - Ergebnisse aus 81 Ländern BT - Results from 81 countries JF - Zeitschrift für Erziehungswissenschaft N2 - Für die Analyse der Unterrichtsqualität von Schulen durch Schülerurteile sollten drei Voraussetzungen erfüllt sein: (1) eine angemessene Übereinstimmung der Schülerurteile innerhalb der Schulen, (2) systematische Variabilität der Schülerurteile zwischen Schulen, (3) ein ausreichendes Maß an Reliabilität der aggregierten Urteile. Diese Studie untersucht mit internationalen PISA-Daten (Zyklen 2000–2012; 81 Länder, über 55.300 Schulen, über 1,3 Millionen 15-Jährige), inwiefern dies für Indikatoren der Qualitätsdimensionen des Unterrichts (Klassenführung, Kognitive Aktivierung, Konstruktive Unterstützung) zutrifft. Dafür bestimmten wir das Übereinstimmungsmaß rWG(J) sowie die Intraklassenkorrelationen ICC(1) und ICC(2). Es zeigte sich, dass (1) die Mehrzahl der Unterrichtsmerkmale eine moderate oder starke Übereinstimmung in Schulen aufwies, (2) sich Unterrichtsmerkmale aus Sicht der Schülerschaft systematisch zwischen Schulen unterschieden, jedoch (3) die Reliabilität der aggregierten Schülerurteile in vielen Ländern nicht ausreichte. Die Ergebnisse diskutieren wir vor dem Hintergrund von Konventionen zur Beurteilung der Übereinstimmung, Variabilität und Reliabilität auf Schulebene. N2 - Using student ratings to assess instructional quality of schools should fulfill three requirements: (1)an appropriate level of inter-rater agreement within schools, (2)systematic variance of student ratings between schools, (3)an adequate reliability level of aggregated student ratings. Using international PISA-data (2000-2012; 81countries, over 55,300 schools, over 1.3million 15-year olds) this study investigated how these requirements were met regarding indicators of instructional quality (classroom management, cognitive activation, individual learning support). We computed the interrater agreement index r(WG(J)), as well as the intraclass correlations ICC(1) and ICC(2). Our results showed that (1)student ratings demonstrated amoderate or strong level of agreement for most indicators of instructional quality and (2)instructional quality assessed by students varied systematically between schools. Yet, (3)reliability of aggregated student ratings was not sufficient in many countries. We discuss these results regarding conventions to evaluate agreement, variability, and reliability of student ratings at the school level. KW - Instructional quality KW - Student ratings KW - PISA Y1 - 2018 U6 - https://doi.org/10.1007/s11618-018-0813-3 SN - 1434-663X SN - 1862-5215 VL - 21 IS - 5 SP - 929 EP - 950 PB - Springer CY - Wiesbaden ER - TY - JOUR A1 - Richter, Philipp A1 - Fox, Andrew J. A1 - Wakker, Bart P. A1 - Howk, J. Christopher A1 - Lehner, Nicolas A1 - Barger, Kathleen A. A1 - Lockman, Felix J. T1 - New constraints on the nature and origin of the leading arm of the magellanic stream JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - We present a new precision measurement of gas-phase abundances of S, O, N, Si, Fe, P, Al, Ca as well as molecular hydrogen (H-2) in the Leading Arm (region II, LA II) of the Magellanic Stream (MS) toward the Seyfert galaxy NGC 3783. The results are based on high-quality archival ultraviolet/optical/radio data from various different instruments (HST/STIS, FUSE, AAT, GBT, GB140 ft, ATCA). Our study updates previous results from lower-resolution data and provides for the first time a self-consistent component model of the complex multiphase absorber, delivering important constraints on the nature and origin of LA II. We derive a uniform, moderate a abundance in the two main absorber groups at +245 and +190 km s(-1) of alpha/H = 0.30 +/- 0.05 solar, a low nitrogen abundance of N/H = 0.05 +/- 0.01 solar, and a high dust content with substantial dust depletion values for Si, Fe, Al, and Ca. These a, N, and dust abundances in LA II are similar to those observed in the Small Magellanic Cloud (SMC). From the analysis of the H2 absorption, we determine a high thermal pressure of P/k approximate to 1680 K cm(-3) in LA II, in line with the idea that LA II is located in the inner Milky Way halo at a z-height of < 20 kpc, where it hydrodynamically interacts with the ambient hot coronal gas. Our study supports a scenario in which LA II stems from the breakup of a metal- and dust-enriched progenitor cloud that was recently (200-500 Myr ago) stripped from the SMC. KW - Galaxy: evolution KW - Galaxy: halo KW - ISM: abundances KW - Magellanic Clouds KW - quasars: absorption lines Y1 - 2018 U6 - https://doi.org/10.3847/1538-4357/aadd0f SN - 0004-637X SN - 1538-4357 VL - 865 IS - 2 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Wolff, Christian Michael A1 - Frischmann, Peter D. A1 - Schulze, Marcus A1 - Bohn, Bernhard J. A1 - Wein, Robin A1 - Livadas, Panajotis A1 - Carlson, Michael T. A1 - Jäckel, Frank A1 - Feldmann, Jochen A1 - Würthner, Frank A1 - Stolarczyk, Jacek K. T1 - All-in-one visible-light-driven water splitting by combining nanoparticulate and molecular co-catalysts on CdS nanorods JF - Nature Energy N2 - Full water splitting into hydrogen and oxygen on semiconductor nanocrystals is a challenging task; overpotentials must be overcome for both half-reactions and different catalytic sites are needed to facilitate them. Additionally, efficient charge separation and prevention of back reactions are necessary. Here, we report simultaneous H-2 and O-2 evolution by CdS nanorods decorated with nanoparticulate reduction and molecular oxidation co-catalysts. The process proceeds entirely without sacrificial agents and relies on the nanorod morphology of CdS to spatially separate the reduction and oxidation sites. Hydrogen is generated on Pt nanoparticles grown at the nanorod tips, while Ru(tpy)(bpy)Cl-2-based oxidation catalysts are anchored through dithiocarbamate bonds onto the sides of the nanorod. O-2 generation from water was verified by O-18 isotope labelling experiments, and time-resolved spectroscopic results confirmed efficient charge separation and ultrafast electron and hole transfer to the reaction sites. The system demonstrates that combining nanoparticulate and molecular catalysts on anisotropic nanocrystals provides an effective pathway for visible-light-driven photocatalytic water splitting. Y1 - 2018 U6 - https://doi.org/10.1038/s41560-018-0229-6 SN - 2058-7546 VL - 3 IS - 10 SP - 862 EP - 869 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Cherstvy, Andrey G. A1 - Nagel, Oliver A1 - Beta, Carsten A1 - Metzler, Ralf T1 - Non-Gaussianity, population heterogeneity, and transient superdiffusion in the spreading dynamics of amoeboid cells JF - Physical chemistry, chemical physics : a journal of European Chemical Societies N2 - What is the underlying diffusion process governing the spreading dynamics and search strategies employed by amoeboid cells? Based on the statistical analysis of experimental single-cell tracking data of the two-dimensional motion of the Dictyostelium discoideum amoeboid cells, we quantify their diffusive behaviour based on a number of standard and complementary statistical indicators. We compute the ensemble- and time-averaged mean-squared displacements (MSDs) of the diffusing amoebae cells and observe a pronounced spread of short-time diffusion coefficients and anomalous MSD-scaling exponents for individual cells. The distribution functions of the cell displacements, the long-tailed distribution of instantaneous speeds, and the velocity autocorrelations are also computed. In particular, we observe a systematic superdiffusive short-time behaviour for the ensemble- and time-averaged MSDs of the amoeboid cells. Also, a clear anti-correlation of scaling exponents and generalised diffusivity values for different cells is detected. Most significantly, we demonstrate that the distribution function of the cell displacements has a strongly non-Gaussian shape andusing a rescaled spatio-temporal variablethe cell-displacement data collapse onto a universal master curve. The current analysis of single-cell motions can be implemented for quantifying diffusive behaviours in other living-matter systems, in particular, when effects of active transport, non-Gaussian displacements, and heterogeneity of the population are involved in the dynamics. Y1 - 2018 U6 - https://doi.org/10.1039/c8cp04254c SN - 1463-9076 SN - 1463-9084 VL - 20 IS - 35 SP - 23034 EP - 23054 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Ambarli, Hüseyin A1 - Mengüllüoğlu, Deniz A1 - Fickel, Jörns A1 - Förster, Daniel W. T1 - Hotel AMANO Grand Central of brown bears in southwest Asia JF - PeerJ N2 - Genetic studies of the Eurasian brown bear (Ursus arctos) have so far focused on populations from Europe and North America, although the largest distribution area of brown bears is in Asia. In this study, we reveal population genetic parameters for the brown bear population inhabiting the Grand Kackar Mountains (GKM) in the north east of Turkey, western Lesser Caucasus. Using both hair (N = 147) and tissue samples (N = 7) collected between 2008 and 2014, we found substantial levels of genetic variation (10 microsatellite loci). Bear samples (hair) taken from rubbing trees worked better for genotyping than those from power poles, regardless of the year collected. Genotyping also revealed that bears moved between habitat patches, despite ongoing massive habitat alterations and the creation of large water reservoirs. This population has the potential to serve as a genetic reserve for future reintroduction in the Middle East. Due to the importance of the GKM population for on-going and future conservation actions, the impacts of habitat alterations in the region ought to be minimized; e.g., by establishing green bridges or corridors over reservoirs and major roads to maintain habitat connectivity and gene flow among populations in the Lesser Caucasus. KW - Ursus arctos KW - Microsatellite KW - Conservation KW - Anatolia KW - Isolation KW - Source population KW - Noninvasive sampling KW - Rubbing tree KW - Turkey Y1 - 2018 U6 - https://doi.org/10.7717/peerj.5660 SN - 2167-8359 VL - 6 PB - PeerJ Inc. CY - London ER - TY - JOUR A1 - Polom, Ulrich A1 - Alrshdan, Hussam A1 - Al-Halbouni, Djamil A1 - Holohan, Eoghan P. A1 - Dahm, Torsten A1 - Sawarieh, Ali A1 - Atallah, Mohamad Y. A1 - Krawczyk, Charlotte M. T1 - Shear wave reflection seismic yields subsurface dissolution and subrosion patterns BT - application to the Ghor Al-Haditha sinkhole site, Dead Sea, Jordan JF - Solid earth N2 - Near-surface geophysical imaging of alluvial fan settings is a challenging task but crucial for understating geological processes in such settings. The alluvial fan of Ghor Al-Haditha at the southeast shore of the Dead Sea is strongly affected by localized subsidence and destructive sinkhole collapses, with a significantly increasing sinkhole formation rate since ca. 1983. A similar increase is observed also on the western shore of the Dead Sea, in correlation with an ongoing decline in the Dead Sea level. Since different structural models of the upper 50 m of the alluvial fan and varying hypothetical sinkhole processes have been suggested for the Ghor Al-Haditha area in the past, this study aimed to clarify the subsurface characteristics responsible for sinkhole development. For this purpose, high-frequency shear wave reflection vibratory seismic surveys were carried out in the Ghor Al-Haditha area along several crossing and parallel profiles with a total length of 1.8 and 2.1 km in 2013 and 2014, respectively. The sedimentary architecture of the alluvial fan at Ghor Al-Haditha is resolved down to a depth of nearly 200 m at a high resolution and is calibrated with the stratigraphic profiles of two boreholes located inside the survey area. The most surprising result of the survey is the absence of evidence of a thick (>2-10 m) compacted salt layer formerly suggested to lie at ca. 35-40 m depth. Instead, seismic reflection amplitudes and velocities image with good continuity a complex interlocking of alluvial fan deposits and lacustrine sediments of the Dead Sea between 0 and 200 m depth. Furthermore, the underground section of areas affected by sinkholes is characterized by highly scattering wave fields and reduced seismic interval velocities. We propose that the Dead Sea mud layers, which comprise distributed inclusions or lenses of evaporitic chloride, sulfate, and carbonate minerals as well as clay silicates, become increasingly exposed to unsaturated water as the sea level declines and are consequently destabilized and mobilized by both dissolution and physical erosion in the subsurface. This new interpretation of the underlying cause of sinkhole development is supported by surface observations in nearby channel systems. Overall, this study shows that shear wave seismic reflection technique is a promising method for enhanced near-surface imaging in such challenging alluvial fan settings. Y1 - 2018 U6 - https://doi.org/10.5194/se-9-1079-2018 SN - 1869-9510 SN - 1869-9529 VL - 9 IS - 5 SP - 1079 EP - 1098 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - von Reppert, Alexander A1 - Willig, Lisa A1 - Pudell, Jan-Etienne A1 - Roessle, M. A1 - Leitenberger, Wolfram A1 - Herzog, Marc A1 - Ganss, F. A1 - Hellwig, O. A1 - Bargheer, Matias T1 - Ultrafast laser generated strain in granular and continuous FePt thin films JF - Applied physics letters N2 - We employ ultrafast X-ray diffraction to compare the lattice dynamics of laser-excited continuous and granular FePt films on MgO (100) substrates. Contrary to recent results on free-standing granular films, we observe in both cases a pronounced and long-lasting out-of-plane expansion. We attribute this discrepancy to the in-plane expansion, which is suppressed by symmetry in continuous films. Granular films on substrates are less constrained and already show a reduced out-of-plane contraction. Via the Poisson effect, out-of-plane contractions drive in-plane expansion and vice versa. Consistently, the granular film exhibits a short-lived out-of-plane contraction driven by ultrafast demagnetization which is followed by a reduced and delayed expansion. From the acoustic reflections of the observed strain waves at the film-substrate interface, we extract a 13% reduction of the elastic constants in thin 10 nm FePt films compared to bulk-like samples. (C) 2018 Author(s). Y1 - 2018 U6 - https://doi.org/10.1063/1.5050234 SN - 0003-6951 SN - 1077-3118 VL - 113 IS - 12 PB - American Institute of Physics CY - Melville ER - TY - JOUR A1 - Ashastina, Kseniia A1 - Kuzmina, Svetlana A1 - Rudaya, Natalia A1 - Troeva, Elena A1 - Schoch, Werner H. A1 - Roemermann, Christine A1 - Reinecke, Jennifer A1 - Otte, Volker A1 - Savvinov, Grigoriy A1 - Wesche, Karsten A1 - Kienast, Frank T1 - Woodlands and steppes BT - Pleistocene vegetation in Yakutia's most continental part recorded in the Batagay permafrost sequence JF - Quaternary science reviews : the international multidisciplinary research and review journal N2 - Based on fossil organism remains including plant macrofossils, charcoal, pollen, and invertebrates preserved in syngenetic deposits of the Batagay permafrost sequence in the Siberian Yana Highlands, we reconstructed the environmental history during marine isotope stages (MIS) 6 to 2. Two fossil assemblages, exceptionally rich in plant remains, allowed for a detailed description of the palaeo-vegetation during two climate extremes of the Late Pleistocene, the onset of the last glacial maximum (LGM) and the last interglacial. In addition, altogether 41 assemblages were used to outline the vegetation history since the penultimate cold stage of MIS 6. Accordingly, meadow steppes analogue to modern communities of the phytosociological order Festucetalia lenensis formed the primary vegetation during the Saalian and Weichselian cold stages. Cold-resistant tundra-steppe communities (Carici rupestris-Kobresietea bellardii) as they occur above the treeline today were, in contrast to more northern locations, mostly lacking. During the last interglacial, open coniferous woodland similar to modern larch taiga was the primary vegetation at the site. Abundant charcoal indicates wildfire events during the last interglacial. Zoogenic disturbances of the local vegetation were indicated by the presence of ruderal plants, especially by abundant Urtica dioica, suggesting that the area was an interglacial refugium for large herbivores. Meadow steppes, which formed the primary vegetation during cold stages and provided potentially suitable pastures for herbivores, were a significant constituent of the plant cover in the Yana Highlands also under the full warm stage conditions of the last interglacial. Consequently, meadow steppes occurred in the Yana Highlands during the entire investigated timespan from MIS 6 to MIS 2 documenting a remarkable environmental stability. Thus, the proportion of meadow steppe vegetation merely shifted in response to the respectively prevailing climatic conditions. Their persistence indicates low precipitation and a relatively warm growing season throughout and beyond the late Pleistocene. The studied fossil record also proves that modern steppe occurrences in the Yana Highlands did not establish as late as in the Holocene but instead are relicts of a formerly continuous steppe belt extending from Central Siberia to Northeast Yakutia during the Pleistocene. The persistence of plants and invertebrates characteristic of meadow steppe vegetation in interior Yakutia throughout the late Quaternary indicates climatic continuity and documents the suitability of this region as a refugium also for other organisms of the Pleistocene mammoth steppe including the iconic large herbivores. (C)2018 Elsevier Ltd. All rights reserved. KW - Palaeo-vegetation KW - Plant macrofossils KW - Invertebrates KW - Modern analogues KW - Pollen KW - Ground squirrel nest KW - Last cold stage KW - Eemian KW - Beringia Y1 - 2018 U6 - https://doi.org/10.1016/j.quascirev.2018.07.032 SN - 0277-3791 VL - 196 SP - 38 EP - 61 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Götz, Klaus-Peter A1 - Naher, Jobadatun A1 - Fettke, Jörg A1 - Chmielewski, Frank M. T1 - Changes of proteins during dormancy and bud development of sweet cherry (Prunus avium L.) JF - Scientia horticulturae : an international journal sponsored by the International Society for Horticultural Science N2 - Trees control the flowering processes in response to both environmental and endogenous (mechanisms at cellular/tissue level) conditions. Dormancy of flower buds is characterized by the reduction of growth and the enhancement of frost and desiccation resistance. The release of endodormancy and the beginning of ontogenetic development, as two important dates for developing reliable phenological models, escape from any visible signs. Thus, we identified - to our knowledge as first - relevant proteins in sweet cherry buds occurring during these phenological phases at high time resolution in three seasons (2012/13–2014/15) under natural conditions in Northeast Germany. The protein content of buds from the first week of October to leaf fall, from leaf fall to the end of endodormancy (t1), from t1 to the beginning of ontogenetic development (t1*), and from t1* until swollen bud, was comparable in each of the seasons. The increase of the protein content began after swollen bud and markedly differences occurred at side green, green tip, tight and open cluster. SDS gel electrophoresis followed by peptide mass fingerprinting accomplished by MALDI-TOF MS was applied for protein identification. ‘Volume intensity’ has been used to demonstrate the pattern and changes of proteins. None of the analysed proteins like for cell proliferation/differentiation (Phytosulfokines 3), carbon fixation (Rubisco), and defense against pathogenes (Major allergen Pru sv 1) indicates the date of endodormancy release or the beginning of the (invisible) ontogenetic development. The stages around green tip, tight, and open cluster resulted in markedly increase of the volume intensity of the protein for cell proliferation/differentiation and the carbon fixation, whereas the volume intensity of a protein for defense against pathogens markedly decreased. The pattern and changes of the volume intensity of neoxanthin synthase (NXS) in sweet cherry buds followed the increasing demand during endo- and ecodormancy to produce neoxanthin, which is a prominent member of the group of reactive oxygen species (ROS) scavengers. KW - Dormancy phases KW - Buds KW - Prunus avium L. KW - Peptide mass fingerprinting Y1 - 2018 U6 - https://doi.org/10.1016/j.scienta.2018.05.016 SN - 0304-4238 SN - 1879-1018 VL - 239 SP - 41 EP - 49 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Markus, Kathrin A1 - Moroz, Lyuba A1 - Arnold, Gabriele A1 - Henckel, Daniela A1 - Hiesinger, Harald A1 - Rohrbach, Arno A1 - Klemme, Stephan T1 - Reflectance spectra of synthetic Fe-free ortho- and clinoenstatites in the UV/VIS/IR and implications for remote sensing detection of Fe-free pyroxenes on planetary surfaces JF - Planetary and space science N2 - Both enstatite spectra are very bright in the VIS and NIR and show almost neutral to slightly bluish spectral slopes with a steep absorption in the UV. Very low iron in the enstatites (below similar to 0.04 wt% FeO) already results in weak albeit noticeable absorptions in the VNIR between 0.4 and 0.9 mu m. Orthoenstatite and clinoenstatite are not distinguishable based only on their spectra in the VIS and NIR. At the Reststrahlen bands in the MIR a systematic difference in the number and exact position of local minima at similar to 10 mu m between clinoenstatite and orthoenstatite is evident. This can be used to discern between the polymorphs in this wavelength range. Additionally, we can distinguish between Fe-free low- and high-Ca pyroxenes in the MIR. KW - Reflectance spectroscopy KW - Remote sensing KW - Enstatite KW - Synthetic pyroxene KW - Analog material Y1 - 2018 U6 - https://doi.org/10.1016/j.pss.2018.04.006 SN - 0032-0633 VL - 159 SP - 43 EP - 55 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Mainka, Stefan A1 - Wissel, Jörg A1 - Völler, Heinz A1 - Evers, Stefan T1 - The Use of Rhythmic Auditory Stimulation to Optimize Treadmill Training for Stroke Patients BT - a randomized controlled trial JF - Frontiers in Neurology N2 - The use of functional music in gait training termed rhythmic auditory stimulation (RAS) and treadmill training (TT) have both been shown to be effective in stroke patients (SP). The combination of RAS and treadmill training (RAS-TT) has not been clinically evaluated to date. The aim of the study was to evaluate the efficacy of RAS-TT on functional gait in SR The protocol followed the design of an explorative study with a rater-blinded three arm prospective randomized controlled parallel group design. Forty-five independently walking SP with a hemiparesis of the lower limb or an unsafe and asymmetrical walking pattern were recruited. RAS-TT was carried out over 4 weeks with TT and neurodevelopmental treatment based on Bobath approach (NDT) serving as control interventions. For RAS-TT functional music was adjusted individually while walking on the treadmill. Pre and post-assessments consisted of the fast gait speed test (FGS), a gait analysis with the locometre (LOC), 3 min walking time test (3MWT), and an instrumental evaluation of balance (IEB). Raters were blinded to group assignments. An analysis of covariance (ANCOVA) was performed with affiliated measures from pre-assessment and time between stroke and start of study as covariates. Thirty-five participants (mean age 63.6 +/- 8.6 years, mean time between stroke and start of study 42.1 +/- 23.7 days) completed the study (11 RAS-TT, 13 TT, 11 NDT). Significant group differences occurred in the FGS for adjusted post-measures in gait velocity [F-(2,F- (34)) = 3.864, p = 0.032; partial eta(2) = 0.205] and cadence [F-(2,F- 34) = 7.656, p = 0.002; partial eta(2) = 0.338]. Group contrasts showed significantly higher values for RAS-TT. Stride length results did not vary between the groups. LOC, 3MWT, and IEB did not indicate group differences. One patient was withdrawn from TT because of pain in one arm. The study provides first evidence for a higher efficacy of RAS-TT in comparison to the standard approaches TT and NDT in restoring functional gait in SP. The results support the implementation of functional music in neurological gait rehabilitation and its use in combination with treadmill training. KW - stroke rehabilitation KW - exercise movement techniques KW - music therapy KW - music KW - gait Y1 - 2018 U6 - https://doi.org/10.3389/fneur.2018.00755 SN - 1664-2295 VL - 9 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Güneysu, Batu A1 - Keller, Matthias T1 - Scattering the Geometry of Weighted Graphs JF - Mathematical physics, analysis and geometry : an international journal devoted to the theory and applications of analysis and geometry to physics N2 - Given two weighted graphs (X, b(k), m(k)), k = 1, 2 with b(1) similar to b(2) and m(1) similar to m(2), we prove a weighted L-1-criterion for the existence and completeness of the wave operators W-+/- (H-2, H-1, I-1,I-2), where H-k denotes the natural Laplacian in l(2)(X, m(k)) w.r.t. (X, b(k), m(k)) and I-1,I-2 the trivial identification of l(2)(X, m(1)) with l(2) (X, m(2)). In particular, this entails a general criterion for the absolutely continuous spectra of H-1 and H-2 to be equal. KW - Graphs KW - Laplacian KW - Scattering theory Y1 - 2018 U6 - https://doi.org/10.1007/s11040-018-9285-1 SN - 1385-0172 SN - 1572-9656 VL - 21 IS - 3 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Warken, Sophie Friederike A1 - Fohlmeister, Jens Bernd A1 - Schröder-Ritzrauh, Andrea A1 - Constantin, Silviu A1 - Spötl, Christoph A1 - Gerdes, Axel A1 - Esper, Jan A1 - Frank, Norbert A1 - Arps, Jennifer A1 - Terente, Mihai A1 - Riechelmann, Dana Felicitas Christine A1 - Mangini, Augusto A1 - Scholz, Denis T1 - Reconstruction of late Holocene autumn/winter precipitation variability in SW Romania from a high-resolution speleothem trace element record JF - Earth & planetary science letters N2 - We present the first high-resolution trace element (Mg/Ca, Sr/Ca, Ba/Ca) record from a stalagmite in southwestern Romania covering the last 3.6 ka, which provides the potential for quantitative climate reconstruction. Precise age control is based on three independent dating methods, in particular for the last 250 yr, where chemical lamina counting is combined with the identification of the 20th century radiocarbon bomb peak and Th-230/U dating. Long-term cave monitoring and model simulations of drip water and speleothem elemental variability indicate that precipitation-related processes are the main drivers of speleothem Mg/Ca ratios. Calibration against instrumental climate data shows a significant anti-correlation of speleothem Mg/Ca ratios with autumn/winter (October to March) precipitation (r = -0.61, p < 0.01), which is statistically robust when considering age uncertainties and auto-correlation. This relationship is used to develop a quantitative reconstruction of autumn/winter precipitation. During the late Holocene, our data suggest a heterogeneous pattern of past regional winter hydroclimate in the Carpathian/Balkan realm, along with intermittent weakening of the dominant influence of North Atlantic forcing. In agreement with other regional paleo-hydrological reconstructions, the observed variability reveals periodically occurring strong NW-SE hydro-climate gradients. We hypothesize, that this pattern is caused by shifts of the eastern edge of the area of influence of the NAO across central eastern Europe due to the confluence of North Atlantic forcing, and other climatic features such as the East Atlantic/Western Russia (EAWR) pattern. (C) 2018 Elsevier B.V. All rights reserved. KW - speleothem KW - trace elements KW - proxy calibration KW - precipitation reconstruction KW - Romania KW - North Atlantic forcing Y1 - 2018 U6 - https://doi.org/10.1016/j.epsl.2018.07.027 SN - 0012-821X SN - 1385-013X VL - 499 SP - 122 EP - 133 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Krauskopf, Karsten A1 - Forssell, Karin T1 - When knowing is believing BT - a multi-trait analysis of self-reported TPCK JF - Journal of Computer Assisted Learning N2 - In an effort to understand teachers' technology use, recent scholarship has explored the idea of technological pedagogical content knowledge (TPCK or TPACK). Many studies have used self-reports to measure this knowledge (SR TPCK). Several studies have examined the construct validity of these assessments by analysing the internal relationships of the knowledge domains, but little attention has been paid to how SR TPCK relates to external criteria. We tackled this question of discriminant validity by reanalysing 2 data sets. We used correlation and multiple regression analyses to explore whether conceptually related constructs explain any variance in participants' SR TPCK. In Study 1, we applied this strategy to German pre-service teachers using technology use, attitudinal variables, and objective measures of teachers' knowledge of technology and pedagogy as external criteria. In Study 2, we examined measures of technology knowledge, experience, and pro-technology beliefs for in-service teachers in the United States. Across both studies, a sizeable amount of the variance in SR TPCK is explained by teachers' prior technology use and pro-technology attitudes. In contrast, fact-based tests of technology and pedagogy are distinct from SR TPCK. We discuss implications for these findings and argue that researchers should gather complementary measures in concert. KW - construct validity KW - education technologies KW - teacher learning KW - self-report KW - teacher beliefs KW - technological pedagogical content knowledge (TPACK KW - TPCK) Y1 - 2018 U6 - https://doi.org/10.1111/jcal.12253 SN - 0266-4909 SN - 1365-2729 VL - 34 IS - 5 SP - 482 EP - 491 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Grünthal, Gottfried A1 - Stromeyer, Dietrich A1 - Bosse, Christian A1 - Cotton, Fabrice Pierre A1 - Bindi, Dino T1 - The probabilistic seismic hazard assessment of Germany-version 2016, considering the range of epistemic uncertainties and aleatory variability JF - Bulletin of earthquake engineering : official publication of the European Association for Earthquake Engineering N2 - The basic seismic load parameters for the upcoming national design regulation for DIN EN 1998-1/NA result from the reassessment of the seismic hazard supported by the German Institution for Civil Engineering (DIBt). This 2016 version of the national seismic hazard assessment for Germany is based on a comprehensive involvement of all accessible uncertainties in models and parameters and includes the provision of a rational framework for integrating ranges of epistemic uncertainties and aleatory variabilities in a comprehensive and transparent way. The developed seismic hazard model incorporates significant improvements over previous versions. It is based on updated and extended databases, it includes robust methods to evolve sets of models representing epistemic uncertainties, and a selection of the latest generation of ground motion prediction equations. The new earthquake model is presented here, which consists of a logic tree with 4040 end branches and essential innovations employed for a realistic approach. The output specifications were designed according to the user oriented needs as suggested by two review teams supervising the entire project. Seismic load parameters, for rock conditions of nu(S30) = 800 m/s, are calculated for three hazard levels (10, 5 and 2% probability of occurrence or exceedance within 50 years) and delivered in the form of uniform hazard spectra, within the spectral period range 0.02-3 s, and seismic hazard maps for peak ground acceleration, spectral response accelerations and for macroseismic intensities. Results are supplied as the mean, the median and the 84th percentile. A broad analysis of resulting uncertainties of calculated seismic load parameters is included. The stability of the hazard maps with respect to previous versions and the cross-border comparison is emphasized. KW - Seismic hazard KW - Germany KW - DIN EN 1998-1/NA KW - Seismic load parameters Y1 - 2018 U6 - https://doi.org/10.1007/s10518-018-0315-y SN - 1570-761X SN - 1573-1456 VL - 16 IS - 10 SP - 4339 EP - 4395 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Archer, A. A1 - Benbow, W. A1 - Bird, R. A1 - Brose, Robert A1 - Buchovecky, M. A1 - Buckley, J. H. A1 - Bugaev, V. A1 - Connolly, M. P. A1 - Cui, W. A1 - Daniel, M. K. A1 - Feng, Q. A1 - Finley, J. P. A1 - Fortson, L. A1 - Furniss, A. A1 - Gillanders, G. A1 - Huetten, M. A1 - Hanna, D. A1 - Hervet, O. A1 - Holder, J. A1 - Hughes, G. A1 - Humensky, T. B. A1 - Johnson, C. A. A1 - Kaaret, P. A1 - Kar, P. A1 - Kelley-Hoskins, N. A1 - Kertzman, M. A1 - Kieda, D. A1 - Krause, M. A1 - Krennrich, F. A1 - Kumar, S. A1 - Lang, M. J. A1 - Lin, T. T. Y. A1 - Maier, G. A1 - McArthur, S. A1 - Moriarty, P. A1 - Mukherjee, R. A1 - Ong, R. A. A1 - Otte, A. N. A1 - Petrashyk, A. A1 - Pohl, M. A1 - Pueschel, Elisa A1 - Quinn, J. A1 - Ragan, K. A1 - Reynolds, P. T. A1 - Richards, G. T. A1 - Roache, E. A1 - Rulten, C. A1 - Sadeh, I. A1 - Santander, M. A1 - Sembroski, G. H. A1 - Staszak, D. A1 - Sushch, I. A1 - Wakely, S. P. A1 - Wells, R. M. A1 - Wilcox, P. A1 - Wilhelm, Alina A1 - Williams, D. A. A1 - Williamson, T. J. A1 - Zitzer, B. T1 - Measurement of cosmic-ray electrons at TeV energies by VERITAS JF - Physical review : D, Particles, fields, gravitation, and cosmology N2 - Cosmic-ray electrons and positrons (CREs) at GeV-TeV energies are a unique probe of our local Galactic neighborhood. CREs lose energy rapidly via synchrotron radiation and inverse-Compton scattering processes while propagating within the Galaxy, and these losses limit their propagation distance. For electrons with TeV energies, the limit is on the order of a kiloparsec. Within that distance, there are only a few known astrophysical objects capable of accelerating electrons to such high energies. It is also possible that the CREs are the products of the annihilation or decay of heavy dark matter (DM) particles. VERITAS, an array of imaging air Cherenkov telescopes in southern Arizona, is primarily utilized for gamma-ray astronomy but also simultaneously collects CREs during all observations. We describe our methods of identifying CREs in VERITAS data and present an energy spectrum, extending from 300 GeV to 5 TeV, obtained from approximately 300 hours of observations. A single power-law fit is ruled out in VERITAS data. We find that the spectrum of CREs is consistent with a broken power law, with a break energy at 710 +/- 40(stat) +/- 140(syst) GeV. Y1 - 2018 U6 - https://doi.org/10.1103/PhysRevD.98.062004 SN - 2470-0010 SN - 2470-0029 VL - 98 IS - 6 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Gonzalez Manrique, Sergio Javier A1 - Kuckein, Christoph A1 - Collados, M. A1 - Denker, Carsten A1 - Solanki, S. K. A1 - Gomory, P. A1 - Verma, Meetu A1 - Balthasar, H. A1 - Lagg, A. A1 - Diercke, Andrea T1 - Temporal evolution of arch filaments as seen in He I 10 830 angstrom JF - Astronomy and astrophysics : an international weekly journal N2 - Aims. We study the evolution of an arch filament system (AFS) and of its individual arch filaments to learn about the processes occurring in them. Methods. We observed the AFS at the GREGOR solar telescope on Tenerife at high cadence with the very fast spectroscopic mode of the GREGOR Infrared Spectrograph (GRIS) in the He I 10 830 angstrom spectral range. The He I triplet profiles were fitted with analytic functions to infer line-of-sight (LOS) velocities to follow plasma motions within the AFS. Results. We tracked the temporal evolution of an individual arch filament over its entire lifetime, as seen in the He I 10 830 angstrom triplet. The arch filament expanded in height and extended in length from 13 ' to 21 '. The lifetime of this arch filament is about 30 min. About 11 min after the arch filament is seen in He I, the loop top starts to rise with an average Doppler velocity of 6 km s(-1). Only two minutes later, plasma drains down with supersonic velocities towards the footpoints reaching a peak velocity of up to 40 km s(-1) in the chromosphere. The temporal evolution of He I 10 830 angstrom profiles near the leading pore showed almost ubiquitous dual red components of the He I triplet, indicating strong downflows, along with material nearly at rest within the same resolution element during the whole observing time. KW - Sun: chromosphere KW - Sun: activity KW - methods: observational KW - methods: data analysis KW - techniques: high angular resolution Y1 - 2018 U6 - https://doi.org/10.1051/0004-6361/201832684 SN - 1432-0746 VL - 617 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Navarro-Retamal, Carlos A1 - Bremer, Anne A1 - Ingolfsson, Helgi I. A1 - Alzate-Morales, Jans A1 - Caballero, Julio A1 - Thalhammer, Anja A1 - Gonzalez, Wendy A1 - Hincha, Dirk K. T1 - Folding and Lipid Composition Determine Membrane Interaction of the Disordered Protein COR15A JF - Biophysical journal N2 - Plants from temperate climates, such as the model plant Arabidopsis thaliana, are challenged with seasonal low temperatures that lead to increased freezing tolerance in fall in a process termed cold acclimation. Among other adaptations, this involves the accumulation of cold-regulated (COR) proteins, such as the intrinsically disordered chloroplast-localized protein COR15A. Together with its close homolog COR15B, it stabilizes chloroplast membranes during freezing. COR15A folds into amphipathic alpha-helices in the presence of high concentrations of low-molecular-mass crowders or upon dehydration. Under these conditions, the (partially) folded protein binds peripherally to membranes. In our study, we have used coarse-grained molecular dynamics simulations to elucidate the details of COR15A-membrane binding and its effects on membrane structure and dynamics. Simulation results indicate that at least partial folding of COR15A and the presence of highly unsaturated galactolipids in the membranes are necessary for efficient membrane binding. The bound protein is stabilized on the membrane by interactions of charged and polar amino acids with galactolipid headgroups and by interactions of hydrophobic amino acids with the upper part of the fatty acyl chains. Experimentally, the presence of liposomes made from a mixture of lipids mimicking chloroplast membranes induces additional folding in COR15A under conditions of partial dehydration, in agreement with the simulation results. Y1 - 2018 U6 - https://doi.org/10.1016/j.bpj.2018.08.014 SN - 0006-3495 SN - 1542-0086 VL - 115 IS - 6 SP - 968 EP - 980 PB - Cell Press CY - Cambridge ER - TY - JOUR A1 - Pauly, Maren A1 - Helle, Gerhard A1 - Miramont, Cecile A1 - Buentgen, Ulf A1 - Treydte, Kerstin A1 - Reinig, Frederick A1 - Guibal, Frederic A1 - Sivan, Olivier A1 - Heinrich, Ingo A1 - Riedel, Frank A1 - Kromer, Bernd A1 - Balanzategui, Daniel A1 - Wacker, Lukas A1 - Sookdeo, Adam A1 - Brauer, Achim T1 - Subfossil trees suggest enhanced Mediterranean hydroclimate variability at the onset of the Younger Dryas JF - Scientific reports N2 - Nearly 13,000 years ago, the warming trend into the Holocene was sharply interrupted by a reversal to near glacial conditions. Climatic causes and ecological consequences of the Younger Dryas (YD) have been extensively studied, however proxy archives from the Mediterranean basin capturing this period are scarce and do not provide annual resolution. Here, we report a hydroclimatic reconstruction from stable isotopes (delta O-18, delta C-13) in subfossil pines from southern France. Growing before and during the transition period into the YD (12 900-12 600 cal BP), the trees provide an annually resolved, continuous sequence of atmospheric change. Isotopic signature of tree sourcewater (delta O-18(sw)) and estimates of relative air humidity were reconstructed as a proxy for variations in air mass origin and precipitation regime. We find a distinct increase in inter-annual variability of sourcewater isotopes (delta O-18(sw)), with three major downturn phases of increasing magnitude beginning at 12 740 cal BP. The observed variation most likely results from an amplified intensity of North Atlantic (low delta O-18(sw)) versus Mediterranean (high delta O-18(sw)) precipitation. This marked pattern of climate variability is not seen in records from higher latitudes and is likely a consequence of atmospheric circulation oscillations at the margin of the southward moving polar front. Y1 - 2018 U6 - https://doi.org/10.1038/s41598-018-32251-2 SN - 2045-2322 VL - 8 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Brügger, Sandra Olivia A1 - Gobet, Erika A1 - Sigl, Michael A1 - Osmont, Dimitri A1 - Papina, Tatyana A1 - Rudaya, Natalia A1 - Schwikowski-Gigar, Margit A1 - Tinner, Willy T1 - Ice records provide new insights into climatic vulnerability of Central Asian forest and steppe communities JF - Global and planetary change N2 - Forest and steppe communities in the Altai region of Central Asia are threatened by changing climate and anthropogenic pressure. Specifically, increasing drought and grazing pressure may cause collapses of moisture-demanding plant communities, particularly forests. Knowledge about past vegetation and fire responses to climate and land use changes may help anticipating future ecosystem risks, given that it has the potential to disclose mechanisms and processes that govern ecosystem vulnerability. We present a unique paleoecological record from the high-alpine Tsambagarav glacier in the Mongolian Altai that provides novel large-scale information on vegetation, fire and pollution with an exceptional temporal resolution and precision. Our palynological record identifies several late-Holocene boreal forest expansions, contractions and subsequent recoveries. Maximum forest expansions occurred at 3000-2800 BC, 2400-2100 BC, and 1900-1800 BC. After 1800 BC mixed boreal forest communities irrecoverably declined. Fires reached a maximum at 1600 BC, 200 years after the final forest collapse. Our multiproxy data suggest that burning peaked in response to dead biomass accumulation resulting from forest diebacks. Vegetation and fire regimes partly decoupled from climate after 1700 AD, when atmospheric industrial pollution began, and land use intensified. We conclude that moisture availability was more important than temperature for past vegetation dynamics, in particular for forest loss and steppe expansion. The past Mongolian Altai evidence implies that in the future forests of the Russian Altai may collapse in response to reduced moisture availability. KW - Boreal forest diebacks KW - Climatic tipping points KW - Diversity KW - Ice core KW - Moisture change KW - Pollen KW - Microscopic charcoal KW - SCP Y1 - 2018 U6 - https://doi.org/10.1016/j.gloplacha.2018.07.010 SN - 0921-8181 SN - 1872-6364 VL - 169 SP - 188 EP - 201 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Quandt, Dennis A1 - Trumbull, Robert B. A1 - Altenberger, Uwe A1 - Cardona, Agustin A1 - Romer, Rolf L. A1 - Bayona, Germán A. A1 - Ducea, Mihai N. A1 - Valencia, Victor A1 - Vasquez, Monica A1 - Cortes, Elizabeth A1 - Guzman, Georgina T1 - The geochemistry and geochronology of Early Jurassic igneous rocks from the Sierra Nevada de Santa Marta, NW Colombia, and tectono-magmatic implications JF - Journal of South American earth sciences N2 - The Sierra Nevada de Santa Marta in NW Colombia is an isolated massif at the northernmost end of the Andes chain near the boundary with the Caribbean plate. Previous geologic mapping and K-Ar dating have shown that Jurassic plutonic and volcanic units make up a large part of the Santa Marta Massif (SMM). These rocks have been considered to be part of a Jurassic magmatic arc extending from NW Colombia to northern Chile, but without any geochemical basis for comparison. This paper reports on a geochemical and Sr-Nd-Pb isotope study of the Jurassic rocks in the SMM and provides 12 new U-Pb zircon ages from in-situ laser ICP-MS dating. The plutonic and volcanic units span a range from 45 to 78 wt.% SiO2, with a dominance of intermediate to felsic compositions with SiO2 > 57 wt.%. They classify as calc-alkaline, medium to high-K, metaluminous rocks with trace-element features typical for arc-derived magma series. In terms of their major and trace-element compositions, the SMM Jurassic units overlap with contemporary plutonic and volcanic rocks from other regions of the Central and Eastern Cordilleras of Colombia, and confirm an arc affinity. The new U-Pb ages range from 176 +/- 1 Ma to 192 +/- 2 Ma (n = 12), with most between 180 and 188 Ma (n = 7). The initial Sr isotope ratios (at 180 Ma) are between 0.7012 and 0.7071 (n = 29), with 3 outliers attributed to mobilization of Rb and/or Sr, Nearly all samples have negative( )epsilon Nd-(180) values between - 10.3 and 0.0 (n = 30), the two exceptions being only slightly positive (1.1 and 1.9). Measured Pb isotope ratios fall in a narrow range, with Pb-206/Pb-204 from 18.02 to 19.95, (207) Pb/(204) Pb from 15.56 to 15.67 and Pb-208/Pb-204 from 37.76 to 39.04 (n = 28). In the regional context of previous studies, these results confirm early Jurassic ages and an arc affinity for the widespread magmatism exposed in the eastern and northeastern Colombian Andes. We also note patterns in the distribution and composition of magmas. The magmatic activity in the Central Cordillera tends to be younger than in the Eastern Cordillera and is spatially more restricted to the vicinity of regional fault systems. In terms of composition, Jurassic igneous rocks in the Eastern Cordillera have systematically lower epsilon Nd-(180) values than those from the Central Cordillera, whereas the Pb isotope ratios overlap. We ascribe the Nd isotope variations to heterogeneity in the mantle source and/or degree of crustal contamination, whereas the Pb isotope ratios are crust-dominated and similar throughout the region. The spatio-temporal and compositional evolution of Jurassic magmatic rocks in the Northern Andes reflect the major plate kinematic readjustment between the Triassic and the Early Jurassic in the proto-Andean margin. KW - Jurassic arc KW - Northern Andes KW - Sr-Nd-Pb isotopes KW - Geochronology Y1 - 2018 U6 - https://doi.org/10.1016/j.jsames.2018.06.019 SN - 0895-9811 VL - 86 SP - 216 EP - 230 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Calvano, Claudia A1 - Warschburger, Petra T1 - Quality of life among parents seeking treatment for their child's functional abdominal pain JF - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation N2 - Purpose: Dealing with a child who suffers from functional abdominal pain (FAP) is a major challenge for the child's parents. However, little is known about the quality of life (QoL) of this group of parents. Therefore, this cross-sectional study aimed to provide a comprehensive analysis of parental QoL among parents seeking treatment for their child's abdominal pain. Methods: 133 parents of 7-13-year-old children diagnosed with FAP reported on their health-related QoL (HRQoL), as assessed by the SF-12, and on caregiver-related QoL, as assessed by two CHQ-PF50 scales (emotional impact, time impact). T tests were used to compare the parents' scores on these measures with reference scores. Subgroups which were at risk of impairment were defined by cut-off scores. Determinants of parental QoL were identified by hierarchical regression analyses. Results: While the parents showed significantly poorer mental health compared to population-based reference samples (d = 0.33-0.58), their physical health did not differ. However, parents were severely strained with respect to the time impact and emotional impact of their child's health (d = 0.33-1.58). While 12.7-27.9% of the parents were at risk of poor HRQoL, 60.6-70.1% were highly strained due to the demands of their role as caregivers. Physical and mental health were best explained by parents' psychiatric symptoms, while parents' perception of their child's impairment additionally determined the high time and emotional impact. Conclusions: Physical HRQoL is not impaired in the majority of parents seeking treatment for their child's functional abdominal pain. However, the time demands and worries due to the child's pain deserve specific attention. Psychosocial interventions for a child's FAP should include information provided to the parents about coping with time constraints and emotional impact. Further prospective studies are warranted. KW - Quality of life KW - Parents KW - SF-12 KW - CHQ-PF50 KW - Functional abdominal pain Y1 - 2018 U6 - https://doi.org/10.1007/s11136-018-1916-2 SN - 0962-9343 SN - 1573-2649 VL - 27 IS - 10 SP - 2557 EP - 2570 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Ramiaramanantsoa, Tahina A1 - Ratnasingam, Rathish A1 - Shenar, Tomer A1 - Moffat, Anthony F. J. A1 - Rogers, Tamara M. A1 - Popowicz, Adam A1 - Kuschnig, Rainer A1 - Pigulski, Andrzej A1 - Handler, Gerald A1 - Wade, Gregg A. A1 - Zwintz, Konstanze A1 - Weiss, Werner W. T1 - A BRITE view on the massive O-type supergiant V973 Scorpii BT - hints towards internal gravity waves or sub-surface convection zones JF - Monthly notices of the Royal Astronomical Society N2 - Stochastically triggered photospheric light variations reaching similar to 40 mmag peak-to-valley amplitudes have been detected in the O8 Iaf supergiant V973 Scorpii as the outcome of 2 months of high-precision time-resolved photometric observations with the BRIght Target Explorer (BRITE) nanosatellites. The amplitude spectrum of the time series photometry exhibits a pronounced broad bump in the low-frequency regime (less than or similar to 0.9 d(-1)) where several prominent frequencies are detected. A time-frequency analysis of the observations reveals typical mode lifetimes of the order of 5-10 d. The overall features of the observed brightness amplitude spectrum of V973 Sco match well with those extrapolated from two-dimensional hydrodynamical simulations of convectively driven internal gravity waves randomly excited from deep in the convective cores of massive stars. An alternative or additional possible source of excitation from a sub-surface convection zone needs to be explored in future theoretical investigations. KW - convection KW - waves KW - techniques: photometric KW - stars: massive KW - supergiants Y1 - 2018 U6 - https://doi.org/10.1093/mnras/sty1897 SN - 0035-8711 SN - 1365-2966 VL - 480 IS - 1 SP - 972 EP - 986 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Reindl, Nicole A1 - Geier, Stephan Alfred A1 - Ostensen, R. H. T1 - Discovery of two bright DO-type white dwarfs JF - Monthly notices of the Royal Astronomical Society N2 - We discovered two bright DO-type white dwarfs, GALEXJ053628.3+544854 (J0536+5448) and GALEXJ231128.0+292935(J2311+2929), which rank among the eight brightest DO-type white dwarfs known. Our non-LTE model atmosphere analysis reveals effective temperatures and surface gravities of T-eff = 80000 +/- 4600K and log g = 8.25 +/- 0.15 for J0536+5448 and T-eff = 69400 +/- 900K and log g = 7.80 +/- 0.06 for J2311+2929. The latter shows a significant amount of carbon in its atmosphere (C = 0.003(-0.002)(+0.005), by mass), while for J0536+5448 we could derive only an upper limit of C < 0.003. Furthermore, we calculated spectroscopic distances for the two stars and found a good agreement with the distances derived from the Gaia parallaxes. KW - stars: abundances KW - stars: atmospheres KW - white dwarfs Y1 - 2018 U6 - https://doi.org/10.1093/mnras/sty1875 SN - 0035-8711 SN - 1365-2966 VL - 480 IS - 1 SP - 1211 EP - 1217 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Iturrizaga, Lasafam T1 - Glacial landform assemblages and pedestal moraines in the Cordillera Check for Blanca (Peru) JF - Geomorphology : an international journal on pure and applied geomorphology N2 - The article provides a contribution to the glacial geomorphology of tropical high-altitude mountains. It focuses on the diversity of glacial landforms in the Cordillera Blanca (Peru). The landforms are classified as individual landform types as well as in their hypsometric sequence. Their spatial arrangement is depicted in vertical series and summarised in a glacial-morphological altitudinal belt model. The glacial landforms are analysed in a genetic succession from the moraine-delimited glacier forefields to the excessive pedestal moraines and taking account of the topographical conditions in the verticality. The Pleistocene glacial relief formation is considered as one of the dominating factors in the development of the moraine types. The sediments are on the one hand in situ deposition forms and on the other depositions dislocated by mass movements and represent paraglacial landforms. Using the example of the Paron Valley in the Artesonraju-Huandoy Massif and neighbouring valleys, the article provides a typology of the range of glacial and paraglacial landforms based on a holistic glacial landsystem approach with special reference to pedestal moraines. (C) 2018 Elsevier B.V. All rights reserved. KW - Tropical high mountains KW - Landform assemblages KW - Glacial geomorphology KW - Pedestal moraine Y1 - 2018 U6 - https://doi.org/10.1016/j.geomorph.2018.06.012 SN - 0169-555X SN - 1872-695X VL - 318 SP - 283 EP - 302 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Hudson, Paul T1 - A comparison of definitions of affordability for flood risk adaption measures BT - a case study of current and future risk-based flood insurance premiums in Europe JF - Mitigation and adaptation strategies for global change : an international journal devoted to scientific, engineering, socio-economic and policy responses to environmental change N2 - Risk-based insurance is a commonly proposed and discussed flood risk adaptation mechanism in policy debates across the world such as in the United Kingdom and the United States of America. However, both risk-based premiums and growing risk pose increasing difficulties for insurance to remain affordable. An empirical concept of affordability is required as the affordability of adaption strategies is an important concern for policymakers, yet such a concept is not often examined. Therefore, a robust metric with a commonly acceptable affordability threshold is required. A robust metric allows for a previously normative concept to be quantified in monetary terms, and in this way, the metric is rendered more suitable for integration into public policy debates. This paper investigates the degree to which risk-based flood insurance premiums are unaffordable in Europe. In addition, this paper compares the outcomes generated by three different definitions of unaffordability in order to investigate the most robust definition. In doing so, the residual income definition was found to be the least sensitive to changes in the threshold. While this paper focuses on Europe, the selected definition can be employed elsewhere in the world and across adaption measures in order to develop a common metric for indicating the potential unaffordability problem. KW - Flood risk KW - Insurance KW - Affordability KW - Climate change KW - Adaptation KW - Public policy Y1 - 2018 U6 - https://doi.org/10.1007/s11027-017-9769-5 SN - 1381-2386 SN - 1573-1596 VL - 23 IS - 7 SP - 1019 EP - 1038 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Awais, Muhammad A1 - Ahmad, Rafiq A1 - Khan, Nadeem A1 - Garapati, Prashanth A1 - Shahzad, Muhammad A1 - Afroz, Amber A1 - Rashid, Umer A1 - Khan, Sabaz Ali T1 - Transformation of tomato variety rio grande with drought resistant transcription factor gene ATAF1 and its molecular analysis JF - Pakistan Journal of Botany N2 - Tomato (Solanum lycopersicum L.) being an important vegetable is cultivated and used throughout the world. It not only contributes in fulfilling the basic nutritional requirements of the human body but also has many health benefits due to its rich biochemical composition. However, its production at large scale is hampered by many limiting factors such as biotic and abiotic stresses. Among the different abiotic stresses, drought poses drastic impact on tomato yield. Drought stress is genetically regulated by many transcription factors that not only regulate the stress responsive mechanism but also facilitate the growth and development of tomato plants. NAC is an important stress related transcription factor genes family, and the ATAF1 gene, a member of this family, is involved in ABA signaling and stress response. In this study, tomato variety Rio Drande was transformed with drought resistant ATAF1 gene via Agrobacterium mediated gene transformation method. The ATAF1 gene was first cloned in the pK7WFG2 vector having kanamycin selectable marker and then it was introduced in the Agrobacterium tumefaciens strain GV3101 through heat shock method. The tomato cotyledon and hypocotyl ex-plants of variety "Rio Ggrande" were cultured on callus induction medium (MS + 2.5 mg/L IAA + 2 mg/L BAP). The calli were then infected with Agrobacterium tumefaciens strain GV3101 containing ATAF1 gene and selection was carried out on the kanamycin selectable medium (MS + 100 mg/L Kan), and were regenerated on MS medium with 1 mg/L IAA + 1 mg/L BAP. Out of 216 putative transformed calli, 13 calli were able to regenerate on the selection medium. Of the 13 calli, three transgenic tomato plantlets were recovered, and these were confirmed through PCR analysis for the presence of 432 bp fragment of ATAF1 gene. The transformation protocol reported here can be used to generate drought resistant tomato plants in future. KW - Agrobacterium tumefaciens KW - drought stress KW - NAC transcription factor ATAF1 KW - plant transformation KW - Rio Grande KW - tomato Y1 - 2018 SN - 0556-3321 SN - 2070-3368 VL - 50 IS - 5 SP - 1811 EP - 1820 PB - Pakistan botanic soc CY - Karachi ER - TY - JOUR A1 - Fudickar, Werner A1 - Linker, Torsten T1 - Release of Singlet Oxygen from Aromatic Endoperoxides by Chemical Triggers JF - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition N2 - The generation of reactive singlet oxygen under mild conditions is of current interest in chemistry, biology, and medicine. We were able to release oxygen from dipyridylanthracene endoperoxides (EPOs) by using a simple chemical trigger at low temperature. Protonation and methylation of such EPOs strongly accelerated these reactions. Furthermore, the methyl pyridinium derivatives are water soluble and therefore serve as oxygen carriers in aqueous media. Methylation of the EPO of the ortho isomer affords the parent form directly without increasing the temperature under very mild conditions. This exceptional behavior is ascribed to the close contact between the nitrogen atom and the peroxo group. Singlet oxygen is released upon this reaction, and can be used to oxygenate an acceptor such as tetramethylethylene in the dark with no heating. Thus, a new chemical source of singlet oxygen has been found, which is triggered by a simple stimulus. KW - anthracenes KW - donor-acceptor systems KW - mild reaction conditions KW - selective oxidations KW - singlet oxygen Y1 - 2018 U6 - https://doi.org/10.1002/anie.201806881 SN - 1433-7851 SN - 1521-3773 VL - 57 IS - 39 SP - 12971 EP - 12975 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Sammoud, Senda A1 - Nevill, Alan Michael A1 - Negra, Yassine A1 - Bouguezzi, Raja A1 - Chaabene, Helmi A1 - Hachana, Younés T1 - Key somatic variables in young backstroke swimmers JF - Journal of sports sciences N2 - The purpose of this study was to estimate the optimal body size, limb-segment length, girth or breadth ratios for 100-m backstroke mean speed performance in young swimmers. Sixty-three young swimmers (boys [n = 30; age: 13.98 ± 0.58 years]; girls [n = 33; age: 13.02 ± 1.20 years]) participated in this study. To identify the optimal body size and body composition components associated with 100-m backstroke speed performance, we adopted a multiplicative allometric log-linear regression model, which was refined using backward elimination. The multiplicative allometric model exploring the association between 100-m backstroke mean speed performance and the different somatic measurements estimated that biological age, sitting height, leg length for the lower-limbs, and two girths (forearm and arm relaxed girth) are the key predictors. Stature and body mass did not contribute to the model, suggesting that the advantage of longer levers was limb-specific rather than a general whole-body advantage. In fact, it is only by adopting multiplicative allometric models that the abovementioned ratios could have been derived. These findings highlighted the importance of considering somatic characteristics of young backstroke swimmers and can help swimming coaches to classify their swimmers and enable them to suggest what might be the swimmers’ most appropriate stroke (talent identification). KW - Allometric models KW - anthropometric measures KW - backstroke swimming KW - gender KW - talent identification Y1 - 2018 U6 - https://doi.org/10.1080/02640414.2018.1546547 SN - 0264-0414 SN - 1466-447X VL - 37 IS - 10 SP - 1162 EP - 1167 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Robrade, Jan A1 - Oskinova, Lida A1 - Schmitt, J. H. M. M. A1 - Leto, Paolo A1 - Trigilio, C. T1 - Outstanding X-ray emission from the stellar radio pulsar CU Virginis JF - Astronomy and astrophysics : an international weekly journal N2 - Context. Among the intermediate-mass magnetic chemically peculiar (MCP) stars, CU Vir is one of the most intriguing objects. Its 100% circularly polarized beams of radio emission sweep the Earth as the star rotates, thereby making this strongly magnetic star the prototype of a class of nondegenerate stellar radio pulsars. While CU Vir is well studied in radio, its high-energy properties are not known. Yet, X-ray emission is expected from stellar magnetospheres and confined stellar winds. Aims. Using X-ray data we aim to test CU Vir for intrinsic X-ray emission and investigate mechanisms responsible for its generation. Methods. We present X-ray observations performed with XMM-Newton and Chandra and study obtained X-ray images, light curves, and spectra. Basic X-ray properties are derived from spectral modelling and are compared with model predictions. In this context we investigate potential thermal and nonthermal X-ray emission scenarios. Results. We detect an X-ray source at the position of CU Vir. With LX approximate to 3 x 10(28) erg s(-1) it is moderately X-ray bright, but the spectrum is extremely hard compared to other Ap stars. Spectral modelling requires multi-component models with predominant hot plasma at temperatures of about T-X = 25MK or, alternatively, a nonthermal spectral component. Both types of model provide a virtually equivalent description of the X-ray spectra. The Chandra observation was performed six years later than those by XMM-Newton, yet the source has similar X-ray flux and spectrum, suggesting a steady and persistent X-ray emission. This is further confirmed by the X-ray light curves that show only mild X-ray variability. Conclusions. CU Vir is also an exceptional star at X-ray energies. To explain its full X-ray properties, a generating mechanism beyond standard explanations, like the presence of a low-mass companion or magnetically confined wind-shocks, is required. Magnetospheric activity might be present or, as proposed for fast-rotating strongly magnetic Bp stars, the X-ray emission of CU Vir is predominantly auroral in nature. KW - individual: CU Vir KW - stars: activity KW - stars: chemically peculiar KW - stars: magnetic field KW - X-rays: stars Y1 - 2018 U6 - https://doi.org/10.1051/0004-6361/201833492 SN - 1432-0746 VL - 619 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Wirsching, Jan A1 - Grassmann, Sophie A1 - Eichelmann, Fabian A1 - Harms, Laura Malin A1 - Schenk, Matthew A1 - Barth, Eva A1 - Berndzen, Alide A1 - Olalekan, Moses A1 - Sarmini, Leen A1 - Zuberer, Hedwig A1 - Aleksandrova, Krasimira T1 - Development and reliability assessment of a new quality appraisal tool for cross-sectional studies using biomarker data (BIOCROSS) JF - BMC Medical Research Methodology N2 - Background Biomarker-based analyses are commonly reported in observational epidemiological studies; however currently there are no specific study quality assessment tools to assist evaluation of conducted research. Accounting for study design and biomarker measurement would be important for deriving valid conclusions when conducting systematic data evaluation. Methods We developed a study quality assessment tool designed specifically to assess biomarker-based cross-sectional studies (BIOCROSS) and evaluated its inter-rater reliability. The tool includes 10-items covering 5 domains: ‘Study rational’, ‘Design/Methods’, ‘Data analysis’, ‘Data interpretation’ and ‘Biomarker measurement’, aiming to assess different quality features of biomarker cross-sectional studies. To evaluate the inter-rater reliability, 30 studies were distributed among 5 raters and intraclass correlation coefficients (ICC-s) were derived from respective ratings. Results The estimated overall ICC between the 5 raters was 0.57 (95% Confidence Interval (CI): 0.38–0.74) indicating a good inter-rater reliability. The ICC-s ranged from 0.11 (95% CI: 0.01–0.27) for the domain ‘Study rational’ to 0.56 (95% CI: 0.40–0.72) for the domain ‘Data interpretation’. Conclusion BIOCROSS is a new study quality assessment tool suitable for evaluation of reporting quality from cross-sectional epidemiological studies employing biomarker data. The tool proved to be reliable for use by biomedical scientists with diverse backgrounds and could facilitate comprehensive review of biomarker studies in human research. KW - BIOCROSS KW - Quality appraisal KW - Evaluation tool KW - Cross-sectional studies Y1 - 2018 U6 - https://doi.org/10.1186/s12874-018-0583-x SN - 1471-2288 VL - 18 PB - BMC CY - London ER - TY - JOUR A1 - Aichner, Bernhard A1 - Ott, Florian A1 - Slowinski, Michal A1 - Norygkiewicz, Agnieszka M. A1 - Brauer, Achim A1 - Sachse, Dirk T1 - Leaf wax n-alkane distributions record ecological changes during the Younger Dryas at Trzechowskie paleolake (northern Poland) without temporal delay JF - Climate of the past : an interactive open access journal of the European Geosciences Union N2 - While of higher plant origin, a specific source assignment of sedimentary leaf wax n-alkanes remains difficult. In addition, it is unknown how fast a changing catchment vegetation would be reflected in sedimentary leaf wax archives. In particular, for a quantitative interpretation of n-alkane C and H isotope ratios in terms of paleohydrological and paleoecological changes, a better understanding of transfer times and dominant sedimentary sources of leaf wax n-alkanes is required. In this study we tested to what extent compositional changes in leaf wax n-alkanes can be linked to known vegetation changes by comparison with high-resolution palynological data from the same archive. We analyzed leaf wax n-alkane concentrations and distributions in decadal resolution from a sedimentary record from Trzechowskie paleolake (TRZ, northern Poland), covering the Late Glacial to early Holocene (13 360-9940 yr BP). As an additional source indicator of targeted n-alkanes, compound-specific carbon isotopic data have been generated in lower time resolution. The results indicated rapid responses of n-alkane distribution patterns coinciding with major climatic and paleoecological transitions. We found a shift towards higher average chain length (ACL) values at the Allerod-Younger Dryas (YD) transition between 12 680 and 12 600 yr BP, co-evaled with a decreasing contribution of arboreal pollen (mainly Pinus and Betula) and a subsequently higher abundance of pollen derived from herbaceous plants (Poaceae, Cyperaceae, Artemisia), shrubs, and dwarf shrubs (Juniperus and Salix). The termination of the YD was characterized by a successive increase in n-alkane concentrations coinciding with a sharp decrease in ACL values between 11 580 and 11 490 yr BP, reflecting the expansion of woodland vegetation at the YD-Holocene transition. A gradual reversal to longer chain lengths after 11 200 yr BP, together with decreasing n-alkane concentrations, most likely reflects the early Holocene vegetation succession with a decline of Betula. These results show that n-alkane distributions reflect vegetation changes and that a fast (i.e., subdecadal) signal transfer occurred. However, our data also indicate that a standard interpretation of directional changes in biomarker ratios remains difficult. Instead, responses such as changes in ACL need to be discussed in the context of other proxy data. In addition, we find that organic geochemical data integrate different ecological information compared to pollen, since some gymnosperm genera, such as Pinus, produce only a very low amount of n-alkanes and for this reason their contribution may be largely absent from biomarker records. Our results demonstrate that a combination of palynological and n-alkane data can be used to infer the major sedimentary leaf wax sources and constrain leaf wax transport times from the plant source to the sedimentary sink and thus pave the way towards quantitative interpretation of compound-specific hydrogen isotope ratios for paleohydrological reconstructions. Y1 - 2018 U6 - https://doi.org/10.5194/cp-14-1607-2018 SN - 1814-9324 SN - 1814-9332 VL - 14 IS - 11 SP - 1607 EP - 1624 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Kruse, Stefan A1 - Gerdes, Alexander A1 - Kath, Nadja J. A1 - Herzschuh, Ulrike T1 - Implementing spatially explicit wind-driven seed and pollen dispersal in the individual-based larch simulation model BT - LAVESI-WIND 1.0 JF - Geoscientific model development : an interactive open access journal of the European Geosciences Union N2 - It is of major interest to estimate the feedback of arctic ecosystems to the global warming we expect in upcoming decades. The speed of this response is driven by the potential of species to migrate, tracking their climate optimum. For this, sessile plants have to produce and disperse seeds to newly available habitats, and pollination of ovules is needed for the seeds to be viable. These two processes are also the vectors that pass genetic information through a population. A restricted exchange among subpopulations might lead to a maladapted population due to diversity losses. Hence, a realistic implementation of these dispersal processes into a simulation model would allow an assessment of the importance of diversity for the migration of plant species in various environments worldwide. To date, dynamic global vegetation models have been optimized for a global application and overestimate the migration of biome shifts in currently warming temperatures. We hypothesize that this is caused by neglecting important fine-scale processes, which are necessary to estimate realistic vegetation trajectories. Recently, we built and parameterized a simulation model LAVESI for larches that dominate the latitudinal treelines in the northernmost areas of Siberia. In this study, we updated the vegetation model by including seed and pollen dispersal driven by wind speed and direction. The seed dispersal is modelled as a ballistic flight, and for the pollination of ovules of seeds produced, we implemented a wind-determined and distance-dependent probability distribution function using a von Mises distribution to select the pollen donor. A local sensitivity analysis of both processes supported the robustness of the model's results to the parameterization, although it highlighted the importance of recruitment and seed dispersal traits for migration rates. This individual-based and spatially explicit implementation of both dispersal processes makes it easily feasible to inherit plant traits and genetic information to assess the impact of migration processes on the genetics. Finally, we suggest how the final model can be applied to substantially help in unveiling the important drivers of migration dynamics and, with this, guide the improvement of recent global vegetation models. Y1 - 2018 U6 - https://doi.org/10.5194/gmd-11-4451-2018 SN - 1991-959X SN - 1991-9603 VL - 11 IS - 11 SP - 4451 EP - 4467 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Kotowski, Elke-Vera T1 - „Heimat“-Objekte BT - Digitale Reise in eine analoge Welt der deutsch-jüdischen Immigration in Lateinamerika JF - Zeitschrift für Religions- und Geistesgeschichte N2 - Bei ihrer zumeist erzwungenen Emigration aus der deutschsprachigen Heimat nach Lateinamerika konnten bei weitem nicht alle ihren gesamten Hausstand mit in das neue Heimatland nehmen. Vielmehr war es der Mehrzahl der Emigranten nicht möglich, mehr als ein paar Kofffer aus ihrem alten Leben in das neue zu retten. Verkauft oder beschlagnahmt, vieles musste zurückbleiben, was über Jahre die Wohnungen und Häuser der deutschen Juden gefüllt hatte. Das Wenige, was doch mitgenommen werden konnte, hatte somit umso mehr persönlichen Wert für den Besitzer. Was also hatten die deutsch-jüdischen Emigranten und Exilanten in ihren Kofffern und weshalb waren gerade diese Objekte für sie bedeutend genug, um sie auf den beschwerlichen Weg über den Atlantik und auf einen neuen Kontinent in eine unbekannte Zukunft mitzunehmen?Eine Antwort auf diese Frage können die Objekte selbst geben, welche bis heute in den Familien der einstigen Emigranten aufbewahrt und benutzt werden. Sie repräsentieren die verlorene Heimat, ein Stück Geschichte des Ursprungslandes und der eigenen Familie. Diese Gegenstände sind mehr als nur Gebrauchsobjekte, welche ihren monetären Wert hatten und daher nicht zurückgelassen werden sollten. Es sind vielmehr Träger von gegebenen und zugeschriebenen Bedeutungen und Erinnerungen an Heimat, die ihnen anhaften und über Generationen hinweg weitergegeben und in ihrem Sym-bolgehalt ergänzt und erweitert werden. Y1 - 2018 U6 - https://doi.org/10.1163/15700739-07004004 SN - 0044-3441 VL - 70 IS - 4 SP - 324 EP - 347 PB - Brill CY - Leiden ER - TY - JOUR A1 - Zimmermann, Malte T1 - Wird Schon Stimmen! BT - A Degree Operator Analysis of Schon JF - Journal of semantics N2 - The article puts forward a novel analysis of the German modal particle schon as a modal degree operator over propositional content. The proposed analysis offers a uniform perspective on the semantics of modal schon and its aspectual counterpart meaning ‘already’: Both particles are analyzed as denoting a degree operator, expressing a scale-based comparison over relevant alternatives. The alternatives are determined by focus in the case of aspectual schon (Krifka 2000), but are restricted to the polar alternatives p and ¬p in the case of modal schon. Semantically, modal schon introduces a presupposition to the effect that the circumstantial conversational background contains more factual evidence in favor of p than in favor of ¬p⁠, thereby making modal schon the not at-issue counterpart of the overt comparative form eher ‘rather’ (Herburger & Rubinstein 2014). The analysis incorporates basic insights from earlier analyses of modal schon in a novel way, and it also offers new insights as to the underlying workings of modality in natural language as involving propositions rather than possible worlds (Kratzer 1977, 2012). Y1 - 2018 U6 - https://doi.org/10.1093/jos/ffy010 SN - 0167-5133 SN - 1477-4593 VL - 35 IS - 4 SP - 687 EP - 739 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Soares, Gabriel A1 - Yamazaki, Yosuke A1 - Matzka, Jürgen A1 - Pinheiro, Katia A1 - Morschhauser, Achim A1 - Stolle, Claudia A1 - Alken, Patrick T1 - Equatorial counter electrojet longitudinal and seasonal variablity in the American sector JF - Journal of geophysical research : Space physics N2 - The equatorial electrojet occasionally reverses during morning and afternoon hours, leading to periods of westward current in the ionospheric E region that are known as counter electrojet (CEJ) events. We present the first analysis of CEJ climatology and CEJ dependence on solar flux and lunar phase for the Brazilian sector, based on an extensive ground-based data set for the years 2008 to 2017 from the geomagnetic observatory Tatuoca (1.2 degrees S, 48.5 degrees W), and we compare it to the results found for Huancayo (12.0 degrees S, 75.3 degrees W) observatory in the Peruvian sector. We found a predominance of morning CEJ events for both sectors. The afternoon CEJ occurrence rate in the Brazilian sector is twice as high as in the Peruvian sector. The afternoon CEJ occurrence rate strongly depends on season, with maximum rates occurring during the northern-hemisphere summer for the Brazilian sector and during the northern-hemisphere winter for the Peruvian sector. Significant discrepancies between the two sectors are also found for morning CEJ rates during the northern-hemisphere summer. These longitudinal differences are in agreement with a CEJ climatology derived from contemporary Swarm satellite data and can be attributed in part to the well-known longitudinal wave-4 structure in the background equatorial electrojet strength that results from nonmigrating solar tides and stationary planetary waves. Simulations with the Thermosphere-Ionosphere-Electrodynamics General Circulation Model show that the remaining longitudinal variability in CEJ during northern summer can be explained by the effect of migrating tides in the presence of the varying geomagnetic field in the South Atlantic Anomaly. Y1 - 2018 U6 - https://doi.org/10.1029/2018JA025968 SN - 2169-9380 SN - 2169-9402 VL - 123 IS - 11 SP - 9906 EP - 9920 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Salamat, Mona A1 - Zöller, Gert A1 - Zare, Mehdi A1 - Amini, Mortaza T1 - The maximum expected earthquake magnitudes in different future time intervals of six seismotectonic zones of Iran and its surroundings JF - Journal of seismology N2 - One of the crucial components in seismic hazard analysis is the estimation of the maximum earthquake magnitude and associated uncertainty. In the present study, the uncertainty related to the maximum expected magnitude mu is determined in terms of confidence intervals for an imposed level of confidence. Previous work by Salamat et al. (Pure Appl Geophys 174:763-777, 2017) shows the divergence of the confidence interval of the maximum possible magnitude m(max) for high levels of confidence in six seismotectonic zones of Iran. In this work, the maximum expected earthquake magnitude mu is calculated in a predefined finite time interval and imposed level of confidence. For this, we use a conceptual model based on a doubly truncated Gutenberg-Richter law for magnitudes with constant b-value and calculate the posterior distribution of mu for the time interval T-f in future. We assume a stationary Poisson process in time and a Gutenberg-Richter relation for magnitudes. The upper bound of the magnitude confidence interval is calculated for different time intervals of 30, 50, and 100 years and imposed levels of confidence alpha = 0.5, 0.1, 0.05, and 0.01. The posterior distribution of waiting times T-f to the next earthquake with a given magnitude equal to 6.5, 7.0, and7.5 are calculated in each zone. In order to find the influence of declustering, we use the original and declustered version of the catalog. The earthquake catalog of the territory of Iran and surroundings are subdivided into six seismotectonic zones Alborz, Azerbaijan, Central Iran, Zagros, Kopet Dagh, and Makran. We assume the maximum possible magnitude m(max) = 8.5 and calculate the upper bound of the confidence interval of mu in each zone. The results indicate that for short time intervals equal to 30 and 50 years and imposed levels of confidence 1 - alpha = 0.95 and 0.90, the probability distribution of mu is around mu = 7.16-8.23 in all seismic zones. KW - Maximum expected earthquake magnitude KW - Future time interval KW - Level of confidence KW - Iran Y1 - 2018 U6 - https://doi.org/10.1007/s10950-018-9780-7 SN - 1383-4649 SN - 1573-157X VL - 22 IS - 6 SP - 1485 EP - 1498 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Asgarimehr, Milad A1 - Wickert, Jens A1 - Reich, Sebastian T1 - TDS-1 GNSS Reflectometry BT - Development and Validation of Forward Scattering Winds JF - IEEE journal of selected topics in applied earth observations and remote sensing N2 - This study presents the development and a systematic evaluation study of GNSS reflectometry wind speeds. After establishing a wind speed retrieval algorithm, UK TechDemoSat-1 (TDS-1) derived winds, from May 2015 to July 2017, are compared to the Advanced Scatterometer (ASCAT). ERA-Interim wind fields of the European Centre for Medium-range Weather Forecasts (ECMWF) and in situ observation from Tropical Atmosphere Ocean buoy array in the Pacific are taken as reference. One-year averaged TDS-1 global winds demonstrate small differences with ECMWF in a majority of areas as well as discuss under- and overestimations. The pioneering TDS-1 winds demonstrate a root-mean-squared error (RMSE) and bias of 2.77 and -0.33 m/s, which are comparable to the RMSE and bias derived by ASCAT winds, as large as 2.31 and 0.25 m/s, respectively. Using buoys measurements as reference, RMSE and bias of 2.23 and -0.03 m/s for TDS-1 as well as 1.40 and -0.68 m/s for ASCAT are obtained. Utilizing rain microwave-infrared estimates of the Tropical Rainfall Measuring Mission, rain-affected observation of both ASCAT and TDS-1 are collected and evaluated. Although ASCAT winds show a significant performance degradation resulting in an RMSE and bias of 3.16 and 1.03 m/s, respectively, during rain condition, TDS-1 shows a more reliable performance with an RMSE and bias of 2.94 and -0.21 m/s, respectively, which indicates the promising capability of GNSS forward scattering for wind retrievals during rain. A decrease in TDS-1-derived bistatic radar cross sections during rain events, at weak winds, is also demonstrated. KW - Advanced scatterometer (ASCAT) KW - European Centre for Medium-Range Weather Forecasts (ECMWF) KW - GNSS forward scatterometry KW - GNSS reflectometry KW - TechDemoSat-1 (TDS-1) KW - wind speed Y1 - 2018 U6 - https://doi.org/10.1109/JSTARS.2018.2873241 SN - 1939-1404 SN - 2151-1535 VL - 11 IS - 11 SP - 4534 EP - 4541 PB - Inst. of Electr. and Electronics Engineers CY - Piscataway ER - TY - JOUR A1 - Möser, Christin A1 - Lorenz, Jessica S. A1 - Sajfutdinow, Martin A1 - Smith, David M. T1 - Pinpointed Stimulation of EphA2 Receptors via DNA-Templated Oligovalence JF - International journal of molecular sciences N2 - DNA nanostructures enable the attachment of functional molecules to nearly any unique location on their underlying structure. Due to their single-base-pair structural resolution, several ligands can be spatially arranged and closely controlled according to the geometry of their desired target, resulting in optimized binding and/or signaling interactions. Here, the efficacy of SWL, an ephrin-mimicking peptide that binds specifically to EphrinA2 (EphA2) receptors, increased by presenting up to three of these peptides on small DNA nanostructures in an oligovalent manner. Ephrin signaling pathways play crucial roles in tumor development and progression. Moreover, Eph receptors are potential targets in cancer diagnosis and treatment. Here, the quantitative impact of SWL valency on binding, phosphorylation (key player for activation) and phenotype regulation in EphA2-expressing prostate cancer cells was demonstrated. EphA2 phosphorylation was significantly increased by DNA trimers carrying three SWL peptides compared to monovalent SWL. In comparison to one of EphA2’s natural ligands ephrin-A1, which is known to bind promiscuously to multiple receptors, pinpointed targeting of EphA2 by oligovalent DNA-SWL constructs showed enhanced cell retraction. Overall, we show that DNA scaffolds can increase the potency of weak signaling peptides through oligovalent presentation and serve as potential tools for examination of complex signaling pathways. KW - DNA nanostructure KW - ephrin KW - EphA2 KW - SWL KW - PC-3 cells KW - multivalence Y1 - 2018 U6 - https://doi.org/10.3390/ijms19113482 SN - 1422-0067 VL - 19 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Afshari Moein, Mohammad J. A1 - Somogyvári, Márk A1 - Valley, Benoît A1 - Jalali, Mohammadreza A1 - Löw, Simon A1 - Bayer, Peter T1 - Fracture network characterization using stress-based tomography JF - Journal of geophysical research : JGR N2 - Information on structural features of a fracture network at early stages of Enhanced Geothermal System development is mostly restricted to borehole images and, if available, outcrop data. However, using this information to image discontinuities in deep reservoirs is difficult. Wellbore failure data provides only some information on components of the in situ stress state and its heterogeneity. Our working hypothesis is that slip on natural fractures primarily controls these stress heterogeneities. Based on this, we introduce stress-based tomography in a Bayesian framework to characterize the fracture network and its heterogeneity in potential Enhanced Geothermal System reservoirs. In this procedure, first a random initial discrete fracture network (DFN) realization is generated based on prior information about the network. The observations needed to calibrate the DFN are based on local variations of the orientation and magnitude of at least one principal stress component along boreholes. A Markov Chain Monte Carlo sequence is employed to update the DFN iteratively by a fracture translation within the domain. The Markov sequence compares the simulated stress profile with the observed stress profiles in the borehole, evaluates each iteration with Metropolis-Hastings acceptance criteria, and stores acceptable DFN realizations in an ensemble. Finally, this obtained ensemble is used to visualize the potential occurrence of fractures in a probability map, indicating possible fracture locations and lengths. We test this methodology to reconstruct simple synthetic and more complex outcrop-based fracture networks and successfully image the significant fractures in the domain. KW - fracture network KW - Bayesian inversion KW - stress variability KW - rock mechanics Y1 - 2018 U6 - https://doi.org/10.1029/2018JB016438 SN - 2169-9313 SN - 2169-9356 VL - 123 IS - 11 SP - 9324 EP - 9340 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Holz, Nathalie E. A1 - Boecker-Schlier, Regina A1 - Jennen-Steinmetz, Christine A1 - Hohm, Erika A1 - Buchmann, Arlette F. A1 - Blomeyer, Dorothea A1 - Baumeister, Sarah A1 - Plichta, Michael M. A1 - Esser, Günter A1 - Schmidt, Martin A1 - Meyer-Lindenberg, Andreas A1 - Banaschewski, Tobias A1 - Brandeis, Daniel A1 - Laucht, Manfred T1 - Early maternal care may counteract familial liability for psychopathology in the reward circuitry JF - Social Cognitive and Affective Neuroscience N2 - Reward processing is altered in various psychopathologies and has been shown to be susceptible to genetic and environmental influences. Here, we examined whether maternal care may buffer familial risk for psychiatric disorders in terms of reward processing. Functional magnetic resonance imaging during a monetary incentive delay task was acquired in participants of an epidemiological cohort study followed since birth (N = 172, 25 years). Early maternal stimulation was assessed during a standardized nursing/playing setting at the age of 3 months. Parental psychiatric disorders (familial risk) during childhood and the participants’ previous psychopathology were assessed by diagnostic interview. With high familial risk, higher maternal stimulation was related to increasing activation in the caudate head, the supplementary motor area, the cingulum and the middle frontal gyrus during reward anticipation, with the opposite pattern found in individuals with no familial risk. In contrast, higher maternal stimulation was associated with decreasing caudate head activity during reward delivery and reduced levels of attention deficit hyperactivity disorder (ADHD) in the high-risk group. Decreased caudate head activity during reward anticipation and increased activity during delivery were linked to ADHD. These findings provide evidence of a long-term association of early maternal stimulation on both adult neurobiological systems of reward underlying externalizing behavior and ADHD during development. KW - maternal care KW - ADHD KW - ventral striatum KW - fMRI KW - resilience KW - aggression Y1 - 2018 U6 - https://doi.org/10.1093/scan/nsy087 SN - 1749-5016 SN - 1749-5024 VL - 13 IS - 11 SP - 1191 EP - 1201 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Dagistanli, Selda A1 - Possamai, Adam A1 - Turner, Bryan S. A1 - Voyce, Malcolm A1 - Roose, Joshua T1 - The limits of multiculturalism in Australia? BT - The Shari’a flogging caseof R v. Raad, Fayed, Cifci and Coskun JF - The Sociological Review N2 - This article focuses on the marginal extremities – the limits – of Shari’a practices in Australia, through the example of a criminal case in which four Sydney-based Muslim men whipped a Muslim convert to punish him for his excessive consumption of drugs and alcohol. The men claimed they acted in line with the doctrines of Shari’a practice to ‘purify’ or absolve the victim of his sins. While the case was tried before a magistrate in a lower court, it is argued in this article that its social and political significance was wider, reaching into contemporary debates around multiculturalism and immigration from non-western, non-liberal and mainly Muslim nations. Mainstream media and political narratives viewed the whipping as an example of the moral dangers of accommodating Shari’a norms, eliding the differences between peaceable Shari’a and its violent extremities, while situating the case at the limits of multicultural accommodation. This article interrogates the objectionable margins of some cultural practices through this limit case. At the same time it questions the limits or limitations of a multiculturalism that homogeneously views the practices of entire ethnic or religious groups as violent and incommensurable with dominant norms, while using these understandings as a justification for marginalising these groups. KW - limits KW - multiculturalism KW - Muslims KW - racism KW - Shari’a Y1 - 2018 U6 - https://doi.org/10.1177/0038026118768133 SN - 0038-0261 SN - 1467-954X VL - 66 IS - 6 SP - 1258 EP - 1275 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Totz, Sonja Juliana A1 - Petri, Stefan A1 - Lehmann, Jascha A1 - Coumou, Dim T1 - Regional Changes in the Mean Position and Variability of the Tropical Edge JF - Geophysical research letters N2 - Recent studies indicate that the tropical belt has been expanding during recent decades, which can significantly influence precipitation in subtropical climates. Often the location of the tropical border is identified using the Hadley cell edge (HCE) or the subtropical jet stream (STJ), but most studies concentrated on the zonal-mean state, thereby missing regional impacts. Here we detect longitudinal-resolved trends in STJ cores and HCEs over 1979-2016 in both hemispheres at a higher spatial and temporal resolution than previous studies. Besides pronounced regional trend differences in both sign and magnitude, we show that winter HCE and STJ variability increased in the Mediterranean region and decreased over the American and Asian continents. Rainfall variability in these regions changed likewise, and most of those changes can be explained by changes in HCE/STJ variability. This highlights the importance of understanding future tropical belt changes both regionally and in terms of variability. Plain Language Summary We applied a new network-based method to detect motion of the tropical climate border with longitudinal resolution. Depending on the longitudinal position, there are differences in both direction and magnitude of the border motion. In addition, we demonstrate that the rainfall variability is increasing in the Mediterranean region and decreasing over the American and Asian continents, which can be explained by the variability of the tropical belt location. Y1 - 2018 U6 - https://doi.org/10.1029/2018GL079911 SN - 0094-8276 SN - 1944-8007 VL - 45 IS - 21 SP - 12076 EP - 12084 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Schwanhold, Nadine A1 - Iobbi-Nivol, Chantal A1 - Lehmann, Angelika A1 - Leimkühler, Silke T1 - Same but different BT - Comparison of two system-specific molecular chaperones for the maturation of formate dehydrogenases JF - PLoS one N2 - The maturation of bacterial molybdoenzymes is a complex process leading to the insertion of the bulky bis-molybdopterin guanine dinucleotide (bis-MGD) cofactor into the apoenzyme. Most molybdoenzymes were shown to contain a specific chaperone for the insertion of the bis-MGD cofactor. Formate dehydrogenases (FDH) together with their molecular chaperone partner seem to display an exception to this specificity rule, since the chaperone FdhD has been proven to be involved in the maturation of all three FDH enzymes present in Escherichia colt. Multiple roles have been suggested for FdhD-like chaperones in the past, including the involvement in a sulfur transfer reaction from the L-cysteine desulfurase IscS to bis-MGD by the action of two cysteine residues present in a conserved CXXC motif of the chaperones. However, in this study we show by phylogenetic analyses that the CXXC motif is not conserved among FdhD-like chaperones. We compared in detail the FdhD-like homologues from Rhodobacter capsulatus and E. colt and show that their roles in the maturation of FDH enzymes from different subgroups can be exchanged. We reveal that bis-MGDbinding is a common characteristic of FdhD-like proteins and that the cofactor is bound with a sulfido-ligand at the molybdenum atom to the chaperone. Generally, we reveal that the cysteine residues in the motif CXXC of the chaperone are not essential for the production of active FDH enzymes. Y1 - 2018 U6 - https://doi.org/10.1371/journal.pone.0201935 SN - 1932-6203 VL - 13 IS - 11 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Haupt, Johannes A1 - Bender, Benedict A1 - Fabian, Benjamin A1 - Lessmann, Stefan T1 - Robust identification of email tracking BT - a machine learning approach JF - European Journal of Operational Research N2 - Email tracking allows email senders to collect fine-grained behavior and location data on email recipients, who are uniquely identifiable via their email address. Such tracking invades user privacy in that email tracking techniques gather data without user consent or awareness. Striving to increase privacy in email communication, this paper develops a detection engine to be the core of a selective tracking blocking mechanism in the form of three contributions. First, a large collection of email newsletters is analyzed to show the wide usage of tracking over different countries, industries and time. Second, we propose a set of features geared towards the identification of tracking images under real-world conditions. Novel features are devised to be computationally feasible and efficient, generalizable and resilient towards changes in tracking infrastructure. Third, we test the predictive power of these features in a benchmarking experiment using a selection of state-of-the-art classifiers to clarify the effectiveness of model-based tracking identification. We evaluate the expected accuracy of the approach on out-of-sample data, over increasing periods of time, and when faced with unknown senders. (C) 2018 Elsevier B.V. All rights reserved. KW - Analytics KW - Data privacy KW - Email tracking KW - Machine learning Y1 - 2018 U6 - https://doi.org/10.1016/j.ejor.2018.05.018 SN - 0377-2217 SN - 1872-6860 VL - 271 IS - 1 SP - 341 EP - 356 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Utecht, Manuel Martin A1 - Gaebel, Tina A1 - Klamroth, Tillmann T1 - Desorption induced by low energy charge carriers on Si(111)-7 x 7 BT - first principles molecular dynamics for benzene derivates JF - Journal of computational chemistry : organic, inorganic, physical, biological N2 - We use clusters for the modeling of local ion resonances caused by low energy charge carriers in STM-induced desorption of benzene derivates from Si(111)-7 x 7. We perform Born-Oppenheimer molecular dynamics for the charged systems assuming vertical transitions to the charged states at zero temperature, to rationalize the low temperature activation energies, which are found in experiment for chlorobenzene. Our calculations suggest very similar low temperature activation energies for toluene and benzene. For the cationic resonance transitions to physisorption are found even at 0 K, while the anion remains chemisorbed during the propagations. Further, we also extend our previous static quantum chemical investigations to toluene and benzene. In addition, an in depth analysis of the ionization potentials and electron affinities, which are used to estimate resonance energies, is given. KW - Born-Oppenheimer MD KW - STM-induced reactions KW - cluster models KW - Si(111)-7x7 Y1 - 2018 U6 - https://doi.org/10.1002/jcc.25607 SN - 0192-8651 SN - 1096-987X VL - 39 IS - 30 SP - 2517 EP - 2525 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Weber, Michael A1 - Scholz, Denis A1 - Schröder-Ritzrau, Andrea A1 - Deininger, Michael A1 - Spötl, Christoph A1 - Lugli, Federico A1 - Mertz-Kraus, Regina A1 - Jochum, Klaus Peter A1 - Fohlmeister, Jens Bernd A1 - Stumpf, Cintia F. A1 - Riechelmann, Dana F. C. T1 - Evidence of warm and humid interstadials in central Europe during early MISSUE 3 revealed by a multi-proxy speleothem record JF - Quaternary science reviews : the international multidisciplinary research and review journal N2 - Marine Isotope Stage 3 (MIS 3, 57-27 ka) was characterised by numerous rapid climate oscillations (i.e., Dansgaard-Oeschger (D/O-) events), which are reflected in various climate archives. So far, MIS 3 speleothem records from central Europe have mainly been restricted to caves located beneath temperate Alpine glaciers or close to the Atlantic Ocean. Thus, MIS 3 seemed to be too cold and dry to enable speleothem growth north of the Alps in central Europe. Here we present a new speleothem record from Bunker Cave, Germany, which shows two distinct growth phases from 52.0 (+0.8, -0.5) to 50.9 (+0.6, -1.3) ka and 473 (+1.0, -0.6) to 42.8 (+/- 0.9) ka, rejecting this hypothesis. These two growth phases potentially correspond to the two warmest and most humid phases in central Europe during MIS 3, which is confirmed by pollen data from the nearby Eifel. The hiatus separating the two phases is associated with Heinrich stadial 5 (HS 5), although the growth stop precedes the onset of HS 5. The first growth phase is characterised by a fast growth rate, and Mg concentrations and Sr isotope data suggest high infiltration and the presence of soil cover above the cave. The second growth phase was characterised by drier, but still favourable conditions for speleothem growth. During this phase, the delta C-13 values show a significant decrease associated with D/O-event 12. The timing of this shift is in agreement with other MIS 3 speleothem data from Europe and Greenland ice core data. (C) 2018 Elsevier Ltd. All rights reserved. KW - Speleothems KW - Pleistocene KW - Palaeoclimatology KW - Europe KW - Dansgaard-Oeschger event KW - Marine isotope stage 3 KW - Bunker cave KW - Multi-proxy approach KW - U-Th series Y1 - 2018 U6 - https://doi.org/10.1016/j.quascirev.2018.09.045 SN - 0277-3791 VL - 200 SP - 276 EP - 286 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Ramos, Catalina A1 - Mechie, James A1 - Stiller, Manfred T1 - Reflection seismic images and amplitude ratio modelling of the Chilean subduction zone at 38.25 degrees S JF - Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth N2 - Active source near-vertical reflection (NVR) data from the interdisciplinary project TIPTEQ were used to image and identify structural and petrophysical properties within the Chilean subduction zone at 38.25 degrees S, where in 1960 the largest earthquake ever recorded (M-w 9.5) occurred. Reflection seismic images of the subduction zone were obtained using the post-stack depth migration technique to process the three components of the NVR data, allowing to present P- and S-stacked time sections and depth-migrated seismic reflection images. Next, the reflectivity method allowed to model traveltimes and amplitude ratios of pairs of reflections for two 1D profiles along the studied transect. The 1D seismic velocities that produced the synthetic seismograms with amplitudes and traveltimes that fit the observed ones were used to infer the rock composition of the different layers in each 1D profile. Finally, an image of the subduction zone is given. The Chilean subduction zone at 38.25 degrees S underlies a continental crust with highly reflective horizontal, as well as dipping events. Among them, the Lanalhue Fault Zone (LFZ), interpreted to be east-dipping, is imaged to very shallow depths for the first time. In terms of seismic velocities, the inferred composition of the continental crust is in agreement with field geology observations at the surface along the profile. Furthermore, no measurable amounts of fluids above the plate interface in the continental crust in this part of the Chilean subduction zone are necessary to explain the results. A large-scale anisotropy in the continental crust and upper mantle is qualitatively proposed. However, quantitative studies on this topic in the continental crust of the Chilean subduction zone at 38.25 degrees S do not exist to date. KW - Reflection seismics KW - Reflectivity method KW - Subduction zone KW - South America Y1 - 2018 U6 - https://doi.org/10.1016/j.tecto.2018.10.007 SN - 0040-1951 SN - 1879-3266 VL - 747 SP - 115 EP - 127 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Reinauer, Christina A1 - Viermann, Rabea A1 - Foertsch, Katharina A1 - Linderskamp, Hannah A1 - Warschburger, Petra A1 - Holl, Reinhard W. A1 - Staab, Doris A1 - Minden, Kirsten A1 - Muche, Rainer A1 - Domhardt, Matthias A1 - Baumeister, Harald A1 - Meissner, Thomas T1 - Motivational Interviewing as a tool to enhance access to mental health treatment in adolescents with chronic medical conditions and need for psychological support (COACH-MI) BT - study protocol for a clusterrandomised controlled trial JF - Trials N2 - Background This cluster-randomised monocentric controlled trial focuses on improving the uptake symptoms of mental health care in adolescents with chronic medical conditions who have been identified by screening to have depression or anxiety. The study aims to determine the efficacy of motivational interviewing (MI) delivered by trained physicians to increase 12- to 20-year-old adolescents’ utilisation of psychological health care for symptoms of anxiety or depression. Methods/design In this single-centre approach, n = 1,000 adolescents will be screened (using PHQ-9 and GAD-7), and adolescents with results indicative of anxiety or depressive symptoms (n = 162) will be advised to seek psychological health care in clusters from treating physicians in specialised outpatient departments. Participants who screen positive will receive either two sessions of MI or treatment as usual (TAU; regarded as the typical daily clinical practice), which is focused on recommending them to seek psychological health care for further evaluation. MI efficacy will be compared to the current TAU as the control condition. The primary outcome is the utilisation rate of psychological health care after counselling by an MI-trained physician vs. an untrained physician. Additionally, reasons for not claiming psychological support and changes in disease-related parameters will be evaluated in a 6-month follow-up session. Discussion This trial will evaluate the feasibility of MI as a way to improve the utilisation of mental health-care services by adolescents who need further support other than that provided by standard care for chronic diseases. Physicians offering MI to adolescents may serve as a model for optimising health-care management in daily clinical practice, which may improve adolescents’ long-term well-being by improving adherence to medical treatment and preventing negative lifelong consequences into adulthood. KW - Adolescents KW - adherence to medical treatment KW - anxiety KW - chronic condition KW - depression KW - motivational interviewing Y1 - 2018 U6 - https://doi.org/10.1186/s13063-018-2997-5 SN - 1745-6215 VL - 19 PB - BMC CY - London ER - TY - JOUR A1 - Rychkov, Dmitry A1 - Altafim, Ruy Alberto Pisani T1 - Template-based fluoroethylenepropylene ferroelectrets with enhanced thermal stability of piezoelectricity JF - Journal of applied physics N2 - In ferroelectrets, the piezoelectricity stems from the charges of both polarities trapped on the inner surfaces of the cavities in the material, so that its thermal stability is defined by the stability of the respective charges. In the present work, a template-based lamination technique has been employed to fabricate tubular-channel ferroelectrets from fluoroethylenepropylene (FEP) films. It has been shown that the piezoelectricity in FEP ferroelectrets decays at relatively low temperatures due to the inherently lower thermal stability of the positive charge. In order to improve charge trapping, we have treated both FEP films and inner surfaces of the ferroelectret cavities with titanium-tetrachloride vapor, using the atomic-layer-deposition technique. Using surface-potential-decay measurements on FEP films, we have found that the charge-decay curves shift by more than 100 degrees C to the higher temperatures as a result of the surface treatment. Direct measurements of piezoelectric d(33) coefficients as a function of temperature have shown that the piezoelectric stability is likewise improved with the d(33)-decay curves shifted by 60 degrees C to the right. The improvement of electret/ferroelectret properties can be attributed to the formation of the deeper traps on the chemically modified FEP surface. SEM micrographs and EDS analysis reveal island-like structures with titanium- and oxygen-containing species that can be responsible for the deeper trapping of the electret charges. Published by AIP Publishing. Y1 - 2018 U6 - https://doi.org/10.1063/1.5041374 SN - 0021-8979 SN - 1089-7550 VL - 124 IS - 17 PB - American Institute of Physics CY - Melville ER - TY - JOUR A1 - Chang, Der-Chen A1 - Mahmoudi, Mahdi Hedayat A1 - Schulze, Bert-Wolfgang T1 - Volterra operators in the edge-calculus JF - Analysis and Mathematical Physics N2 - We study the Volterra property of a class of anisotropic pseudo-differential operators on R x B for a manifold B with edge Y and time-variable t. This exposition belongs to a program for studying parabolicity in such a situation. In the present consideration we establish non-smoothing elements in a subalgebra with anisotropic operator-valued symbols of Mellin type with holomorphic symbols in the complex Mellin covariable from the cone theory, where the covariable t of t extends to symbolswith respect to t to the lower complex v half-plane. The resulting space ofVolterra operators enlarges an approach of Buchholz (Parabolische Pseudodifferentialoperatoren mit operatorwertigen Symbolen. Ph. D. thesis, Universitat Potsdam, 1996) by necessary elements to a new operator algebra containing Volterra parametrices under an appropriate condition of anisotropic ellipticity. Our approach avoids some difficulty in choosing Volterra quantizations in the edge case by generalizing specific achievements from the isotropic edge-calculus, obtained by Seiler (Pseudodifferential calculus on manifolds with non-compact edges, Ph. D. thesis, University of Potsdam, 1997), see also Gil et al. (in: Demuth et al (eds) Mathematical research, vol 100. Akademic Verlag, Berlin, pp 113-137, 1997; Osaka J Math 37: 221-260, 2000). KW - Volterra operator KW - Anisotropic pseudo-differential operators KW - Edge calculus KW - Operator-valued symbols of Mellin type Y1 - 2018 U6 - https://doi.org/10.1007/s13324-018-0238-4 SN - 1664-2368 SN - 1664-235X VL - 8 IS - 4 SP - 551 EP - 570 PB - Springer CY - Basel ER - TY - JOUR A1 - Reil, Daniela A1 - Binder, Florian A1 - Freise, Jona A1 - Imholt, Christian A1 - Beyrers, Konrad A1 - Jacob, Jens A1 - Krüger, Detlev H. A1 - Hofmann, Jörg A1 - Dreesman, Johannes A1 - Ulrich, Rainer Günter T1 - Hantaviren in Deutschland BT - Aktuelle Erkenntnisse zu Erreger, Reservoir, Verbreitung und Prognosemodellen JF - Berliner und Münchener tierärztliche Wochenschrift N2 - Hantaviruses are small mammal-associated pathogens that are found in rodents but also in shrews, moles and bats. Aim of this manuscript is to give a current overview of the epidemiology and ecology of hantaviruses in Germany and to discuss respective models for the prediction of virus outbreaks. In Germany the majority of human disease cases are caused by the Puumala virus (PUUV), transmitted by the bank vole (Myodes glareolus). PUUV is associated with the Western evolutionary lineage of the bank vole and is not present in the eastern and northern parts of Germany. A second human pathogenic hantavirus is the Dobrava-Belgrade virus (DOBV), genotype Kurkino; its reservoir host, the striped field mouse (Apodemus agrarius), is mostly occurring in the eastern part of Germany. A PUUV-related hantavirus is the rarely pathogenic Tula virus (TULV), that is associated with the common vole (Microtus arvalis). In addition, Seewis virus, Asikkala virus, and Bruges virus are shrew- and mole-associated hantaviruses with still unknown pathogenicity in humans. Human disease cases are associated with the different hantaviruses according to their regional distribution. The viruses can cause mild to severe but also subclinical courses of the respective disease. The number of human PUUV disease cases in 2007, 2010, 2012, 2015 and 2017 correlates with the occurrence of high levels of seed production of beech trees ("beech mast") in the preceding year. Models based on weather parameters for the prediction of PUUV disease clusters as developed in recent years need further validation and optimisation. in addition to the abundance of infected reservoir rodents, the exposure behaviour of humans affects the risk of human infection. The application of robust forecast models can assist the public health service to develop and communicate spatially and temporally targeted information. Thus, further recommendations to mitigate infection risk for the public may be provided. N2 - Hantaviren sind Kleinsäuger-assoziierte Krankheitserreger, die vor allem in Nagetieren, aber auch in Spitzmäusen, Maulwürfen und Fledermäusen vorkommen. Ziel dieser Arbeit ist es, einen aktuellen Überblick zur Epidemiologie und Ökologie der Hantaviren in Deutschland zu geben und Modelle zur Vorhersage von Virusausbrüchen zu diskutieren. In Deutschland werden die meisten humanen Erkrankungsfälle beim Menschen durch das von der Rötelmaus (Myodes glareolus) übertragene Puumalavirus (PUUV) verursacht. PUUV ist mit der westlichen evolutionären Linie der Rötelmaus assoziiert und fehlt im östlichen und nördlichen Teil Deutschlands. Ein zweites humanpathogenes Hantavirus ist das Dobrava-Belgrad-Virus (DOBV), Genotyp Kurkino, dessen Reservoir die vor allem im östlichen Teil Deutschlands vorkommende Brandmaus (Apodemus agrarius) ist. Ein PUUV-verwandtes Hantavirus ist das selten humanpathogene Tulavirus (TULV), das mit der Feldmaus (Microtus arvalis) assoziiert ist. Darüber hinaus wurden mit dem Seewis-, Asikkala- und Brugesvirus Spitzmaus- und Maulwurf-assoziierte Hantaviren mit noch unklarer Humanpathogenität gefunden. Die humanen Erkrankungen sind jeweils mit den verschiedenen Hantaviren in deren regionaler Verteilung assoziiert und können mild bis schwer, aber auch subklinisch verlaufen. Das Auftreten von Häufungen humaner, durch PUUV verursachter Erkrankungen in den Jahren 2007, 2010, 2012, 2015 und 2017 korreliert mit dem Auftreten einer starken Fruktifikation der Buche („Buchenmast“) im jeweiligen Vorjahr. Auf der Basis von Wetterparametern sind Modelle zur Vorhersage von PUUV-Erkrankungshäufungen entwickelt worden, die zukünftig validiert und optimiert werden müssen. Neben dem Ausmaß des Virusvorkommens im Reservoir wird das Risiko humaner Infektionen durch das Expositionsverhalten des Menschen beeinflusst. Durch die Anwendung von Prognosemodellen soll der öffentliche Gesundheitsdienst in die Lage versetzt werden, räumlich und zeitlich gezielte und sachgerechte Präventionsempfehlungen für die Bevölkerung abzugeben. T2 - Hantaviruses in Germany: current knowledge on pathogens, reservoirs, distribution and forecast models KW - early warning system KW - hantavirus KW - hantavirus disease KW - rodents KW - population dynamics KW - Frühwarn-System KW - Hantavirus KW - Hantavirus-Erkrankung KW - Nagetiere KW - Populationsdynamik Y1 - 2018 U6 - https://doi.org/10.2376/0005-9366-18003 SN - 0005-9366 SN - 1439-0299 VL - 131 IS - 11-12 SP - 453 EP - 464 PB - Schlütersche Verlagsgesellschaft mbH & Co. KG. CY - Hannover ER - TY - JOUR A1 - Yalew, S. G. A1 - Pilz, Tobias A1 - Schweitzer, C. A1 - Liersch, Stefan A1 - van der Kwast, J. A1 - van Griensven, A. A1 - Mul, Marloes L. A1 - Dickens, Chris A1 - van der Zaag, Pieter T1 - Coupling land-use change and hydrologic models for quantification of catchment ecosystem services JF - Environmental modelling & software with environment data news N2 - Representation of land-use and hydrologic interactions in respective models has traditionally been problematic. The use of static land-use in most hydrologic models or that of the use of simple hydrologic proxies in land-use change models call for more integrated approaches. The objective of this study is to assess whether dynamic feedback between land-use change and hydrology can (1) improve model performances, and/or (2) produce a more realistic quantification of ecosystem services. To test this, we coupled a land-use change model and a hydrologic mode. First, the land-use change and the hydrologic models were separately developed and calibrated. Then, the two models were dynamically coupled to exchange data at yearly time-steps. The approach is applied to a catchment in South Africa. Performance of coupled models when compared to the uncoupled models were marginal, but the coupled models excelled at the quantification of catchment ecosystem services more robustly. KW - Model coupling KW - Ecosystem services KW - Integrated modelling KW - Land and water Y1 - 2018 U6 - https://doi.org/10.1016/j.envsoft.2018.08.029 SN - 1364-8152 SN - 1873-6726 VL - 109 SP - 315 EP - 328 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Tabben, Montassar A1 - Ihsan, Mohammed A1 - Ghoul, Nihel A1 - Coquart, Jeremy A1 - Chaouachi, Anis A1 - Chaabene, Helmi A1 - Tourny, Claire A1 - Chamari, Karim T1 - Performance 24-h After a Simulated Mixed Martial Arts Combat JF - Frontiers in physiology N2 - Objective: The aim of the present study was to examine the effect of Cold Water Immersion (CWI) on the recovery of physical performance, hematological stress markers and perceived wellness (i.e., Hooper scores) following a simulated Mixed Martial Arts (MMA) competition. Methods: Participants completed two experimental sessions in a counter-balanced order (CWI or passive recovery for control condition: CON), after a simulated MMAs competition (3 x 5-min MMA rounds separated by 1-min of passive rest). During CWI, athletes were required to submerge their bodies, except the trunk, neck and head, in the seated position in a temperature-controlled bath (similar to 10 degrees C) for 15-min. During CON, athletes were required to be in a seated position for 15-min in same room ambient temperature. Venous blood samples (creatine kinase, cortisol, and testosterone concentrations) were collected at rest (PRE-EX, i.e., before MMAs), immediately following MMAs (POST-EX), immediately following recovery (POST-R) and 24 h post MMAs (POST-24), whilst physical fitness (squat jump, countermovement-jump and 5- and 10-m sprints) and perceptual measures (well-being Hooper index: fatigue, stress, delayed onset muscle soreness (DOMS), and sleep) were collected at PRE-EX, POST-R and POST-24, and at PRE-EX and POST-24, respectively. Conclusion: The use of CWI resulted in an enhanced recovery of 10-m sprint performance, as well as improved perceived wellness 24-h following simulated MMA competition. KW - recovery KW - combat sports KW - MMA KW - delayed onset muscle soreness KW - stress KW - fatigue Y1 - 2018 U6 - https://doi.org/10.3389/fphys.2018.01542 SN - 1664-042X VL - 9 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Agarwal, Ankit A1 - Maheswaran, Rathinasamy A1 - Marwan, Norbert A1 - Caesar, Levke A1 - Kurths, Jürgen T1 - Wavelet-based multiscale similarity measure for complex networks JF - The European physical journal : B, Condensed matter and complex systems N2 - In recent years, complex network analysis facilitated the identification of universal and unexpected patterns in complex climate systems. However, the analysis and representation of a multiscale complex relationship that exists in the global climate system are limited. A logical first step in addressing this issue is to construct multiple networks over different timescales. Therefore, we propose to apply the wavelet multiscale correlation (WMC) similarity measure, which is a combination of two state-of-the-art methods, viz. wavelet and Pearson’s correlation, for investigating multiscale processes through complex networks. Firstly we decompose the data over different timescales using the wavelet approach and subsequently construct a corresponding network by Pearson’s correlation. The proposed approach is illustrated and tested on two synthetics and one real-world example. The first synthetic case study shows the efficacy of the proposed approach to unravel scale-specific connections, which are often undiscovered at a single scale. The second synthetic case study illustrates that by dividing and constructing a separate network for each time window we can detect significant changes in the signal structure. The real-world example investigates the behavior of the global sea surface temperature (SST) network at different timescales. Intriguingly, we notice that spatial dependent structure in SST evolves temporally. Overall, the proposed measure has an immense potential to provide essential insights on understanding and extending complex multivariate process studies at multiple scales. KW - Statistical and Nonlinear Physics Y1 - 2018 U6 - https://doi.org/10.1140/epjb/e2018-90460-6 SN - 1434-6028 SN - 1434-6036 VL - 91 IS - 11 PB - Springer CY - New York ER - TY - JOUR A1 - Hameister, Inga A1 - Nickels, Lyndsey T1 - The cat in the tree - using picture descriptions to inform our understanding of conceptualisation in aphasia JF - Language, cognition and neuroscience N2 - Conceptualisation is the first step of speech production and describes the process by which we map our thoughts onto spoken language. Recent studies suggest that some people with language impairments have conceptualisation deficits manifested by information selection and sequencing difficulties. In this study, we examined conceptualisation in the complex picture descriptions of individuals with and without aphasia. We analysed the number and the order of main concepts (ideas produced by >= 60% of unimpaired speakers) and non-main concepts (e.g. irrelevant details). Half of the individuals with aphasia showed a reduced number of main concepts that could not be fully accounted for by their language production deficits. Moreover, individuals with aphasia produced both a larger amount of marginally relevant information, as well as having greater variability in the order of main concepts. Both findings provide support for the idea that conceptualisation deficits are a relatively common impairment in people with aphasia. KW - Aphasia KW - conceptualisation KW - discourse KW - concept analysis KW - macroplanning Y1 - 2018 U6 - https://doi.org/10.1080/23273798.2018.1497801 SN - 2327-3798 SN - 2327-3801 VL - 33 IS - 10 SP - 1296 EP - 1314 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Siddiqui, Tarique Adnan A1 - Maute, Astrid A1 - Pedatella, Nick A1 - Yamazaki, Yosuke A1 - Lühr, Hermann A1 - Stolle, Claudia T1 - On the variability of the semidiurnal solar and lunar tides of the equatorial electrojet during sudden stratospheric warmings JF - Annales geophysicae N2 - The variabilities of the semidiurnal solar and lunar tides of the equatorial electrojet (EEJ) are investigated during the 2003, 2006, 2009 and 2013 major sudden stratospheric warming (SSW) events in this study. For this purpose, ground-magnetometer recordings at the equatorial observatories in Huancayo and Fuquene are utilized. Results show a major enhancement in the amplitude of the EEJ semidiurnal lunar tide in each of the four warming events. The EEJ semidiurnal solar tidal amplitude shows an amplification prior to the onset of warmings, a reduction during the deceleration of the zonal mean zonal wind at 60 degrees N and 10 hPa, and a second enhancement a few days after the peak reversal of the zonal mean zonal wind during all four SSWs. Results also reveal that the amplitude of the EEJ semidiurnal lunar tide becomes comparable or even greater than the amplitude of the EEJ semidiurnal solar tide during all these warming events. The present study also compares the EEJ semidiurnal solar and lunar tidal changes with the variability of the migrating semidiurnal solar (SW2) and lunar (M2) tides in neutral temperature and zonal wind obtained from numerical simulations at E-region heights. A better agreement between the enhancements of the EEJ semidiurnal lunar tide and the M2 tide is found in comparison with the enhancements of the EEJ semidiurnal solar tide and the SW2 tide in both the neutral temperature and zonal wind at the E-region altitudes. Y1 - 2018 U6 - https://doi.org/10.5194/angeo-36-1545-2018 SN - 0992-7689 SN - 1432-0576 VL - 36 IS - 6 SP - 1545 EP - 1562 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Werno, Martin Witold A1 - Wilhelmi, Ilka A1 - Kuropka, Benno A1 - Ebert, Franziska A1 - Freund, Christian A1 - Schürmann, Annette T1 - The GTPase ARFRP1 affects lipid droplet protein composition and triglyceride release from intracellular storage of intestinal Caco-2 cells JF - Biochemical and biophysical research communications N2 - Intestinal release of dietary triglycerides via chylomicrons is the major contributor to elevated postprandial triglyceride levels. Dietary lipids can be transiently stored in cytosolic lipid droplets (LDs) located in intestinal enterocytes for later release. ADP ribosylation factor-related protein 1 (ARFRP1) participates in processes of LD growth in adipocytes and in lipidation of lipoproteins in liver and intestine. This study aims to explore the impact of ARFRP1 on LD organization and its interplay with chylomicron-mediated triglyceride release in intestinal-like Caco-2 cells. Suppression of Arfrp1 reduced release of intracellularly derived triglycerides (0.69-fold) and increased the abundance of transitional endoplasmic reticulum ATPase TERA/VCP, fatty acid synthase-associated factor 2 (FAF2) and perilipin 2 (Plin2) at the LD surface. Furthermore, TERA/VCP and FAF2 co-occurred more frequently with ATGL at LDs, suggesting a reduced adipocyte triglyceride lipase (ATGL)-mediated lipolysis. Accordingly, inhibition of lipolysis reduced lipid release from intracellular storage pools by the same magnitude as Arfrp1 depletion. Thus, the lack of Arfrp1 increases the abundance of lipolysis-modulating enzymes TERA/VCP, FAF2 and Plin2 at LDs, which might decrease lipolysis and reduce availability of fatty acids for triglyceride synthesis and their release via chylomicrons. (C) 2018 The Authors. Published by Elsevier Inc. KW - Chylomicron KW - Lipid droplet proteome KW - Triglyceride secretion KW - Lipolysis Y1 - 2018 U6 - https://doi.org/10.1016/j.bbrc.2018.10.092 SN - 0006-291X SN - 1090-2104 VL - 506 IS - 1 SP - 259 EP - 265 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Al-Halbouni, Djamil A1 - Holohan, Eoghan P. A1 - Taheri, Abbas A1 - Schöpfer, Martin P. J. A1 - Emam, Sacha A1 - Dahm, Torsten T1 - Geomechanical modelling of sinkhole development using distinct elements BT - model verification for a single void space and application to the Dead Sea area JF - Solid earth N2 - Mechanical and/or chemical removal of material from the subsurface may generate large subsurface cavities, the destabilisation of which can lead to ground collapse and the formation of sinkholes. Numerical simulation of the interaction of cavity growth, host material deformation and overburden collapse is desirable to better understand the sinkhole hazard but is a challenging task due to the involved high strains and material discontinuities. Here, we present 2-D distinct element method numerical simulations of cavity growth and sinkhole development. Firstly, we simulate cavity formation by quasi-static, stepwise removal of material in a single growing zone of an arbitrary geometry and depth. We benchmark this approach against analytical and boundary element method models of a deep void space in a linear elastic material. Secondly, we explore the effects of properties of different uniform materials on cavity stability and sinkhole development. We perform simulated biaxial tests to calibrate macroscopic geotechnical parameters of three model materials representative of those in which sinkholes develop at the Dead Sea shoreline: mud, alluvium and salt. We show that weak materials do not support large cavities, leading to gradual sagging or suffusion-style subsidence. Strong materials support quasi-stable to stable cavities, the overburdens of which may fail suddenly in a caprock or bedrock collapse style. Thirdly, we examine the consequences of layered arrangements of weak and strong materials. We find that these are more susceptible to sinkhole collapse than uniform materials not only due to a lower integrated strength of the overburden but also due to an inhibition of stabilising stress arching. Finally, we compare our model sinkhole geometries to observations at the Ghor Al-Haditha sinkhole site in Jordan. Sinkhole depth / diameter ratios of 0.15 in mud, 0.37 in alluvium and 0.33 in salt are reproduced successfully in the calibrated model materials. The model results suggest that the observed distribution of sinkhole depth / diameter values in each material type may partly reflect sinkhole growth trends. Y1 - 2018 U6 - https://doi.org/10.5194/se-9-1341-2018 SN - 1869-9510 SN - 1869-9529 VL - 9 IS - 6 SP - 1341 EP - 1373 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Sposini, Vittoria A1 - Chechkin, Aleksei V. A1 - Metzler, Ralf T1 - First passage statistics for diffusing diffusivity JF - Journal of physics : A, Mathematical and theoretical N2 - A rapidly increasing number of systems is identified in which the stochastic motion of tracer particles follows the Brownian law < r(2)(t)> similar or equal to Dt yet the distribution of particle displacements is strongly non-Gaussian. A central approach to describe this effect is the diffusing diffusivity (DD) model in which the diffusion coefficient itself is a stochastic quantity, mimicking heterogeneities of the environment encountered by the tracer particle on its path. We here quantify in terms of analytical and numerical approaches the first passage behaviour of the DD model. We observe significant modifications compared to Brownian-Gaussian diffusion, in particular that the DD model may have a faster first passage dynamics. Moreover we find a universal crossover point of the survival probability independent of the initial condition. KW - diffusion KW - superstatistics KW - first passage Y1 - 2018 U6 - https://doi.org/10.1088/1751-8121/aaf6ff SN - 1751-8113 SN - 1751-8121 VL - 52 IS - 4 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Kayatz, Benjamin A1 - Baroni, Gabriele A1 - Hillier, Jon A1 - Lüdtke, Stefan A1 - Heathcote, Richard A1 - Malin, Daniella A1 - van Tonder, Carl A1 - Kuster, Benjamin A1 - Freese, Dirk A1 - Hüttl, Reinhard A1 - Wattenbach, Martin T1 - Cool farm tool water BT - A global on-line tool to assess water use in crop production JF - Journal of cleaner production N2 - The agricultural sector accounts for 70% of all water consumption and poses great pressure on ground water resources. Therefore, evaluating agricultural water consumption is highly important as it allows supply chain actors to identify practices which are associated with unsustainable water use, which risk depleting current water resources and impacting future production. However, these assessments are often not feasible for crop producers as data, models and experiments are required in order to conduct them. This work introduces a new on-line agricultural water use assessment tool that provides the water footprint and irrigation requirements at field scale based on an enhanced FAO56 approach combined with a global climate, crop and soil databases. This has been included in the Cool Farm Tool - an online tool which already provides metrics for greenhouse gas emissions and biodiversity impacts and therefore allows for a more holistic assessment of environmental sustainability in farming and agricultural supply chains. The model is tested against field scale and state level water footprint data providing good results. The tool provides a practical, reliable way to assess agricultural water use, and offers a means to engage growers and stakeholders in identifying efficient water management practices. (C) 2018 The Authors. Published by Elsevier Ltd. KW - Water footprint KW - FAO56 KW - Crop water use KW - Stakeholder involvement KW - Water resource management KW - Irrigation requirements Y1 - 2018 SN - 0959-6526 SN - 1879-1786 VL - 207 SP - 1163 EP - 1179 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Jonscher, Ernst A1 - Flemming, Sven A1 - Schmitt, Marius A1 - Sabitzki, Ricarda A1 - Reichard, Nick A1 - Birnbaum, Jakob A1 - Bergmann, Bärbel A1 - Höhn, Katharina A1 - Spielmann, Tobias T1 - PfVPS45 Is Required for Host Cell Cytosol Uptake by Malaria Blood Stage Parasites JF - Cell host & microbe N2 - During development in human erythrocytes, the malaria parasite Plasmodium falciparum internalizes a large part of the cellular content of the host cell. The internalized cytosol, consisting largely of hemoglobin, is transported to the parasite’s food vacuole where it is degraded, providing nutrients and space for growth. This host cell cytosol uptake (HCCU) is crucial for parasite survival but the parasite proteins mediating this process remain obscure. Here, we identify P. falciparum VPS45 as an essential factor in HCCU. Conditional inactivation of PfVPS45 led to an accumulation of host cell cytosol-filled vesicles within the parasite and inhibited the delivery of hemoglobin to the parasite's digestive vacuole, resulting in arrested parasite growth. A proportion of these HCCU vesicle intermediates was positive for phosphatidylinositol 3-phosphate, suggesting endosomal characteristics. Thus PfVPS45 provides insight into the elusive machinery of the ingestion pathway in a parasite that contains an endolysosomal system heavily repurposed for protein secretion. Y1 - 2018 U6 - https://doi.org/10.1016/j.chom.2018.11.010 SN - 1931-3128 SN - 1934-6069 VL - 25 IS - 1 SP - 166 EP - 173 PB - Cell Press CY - Cambridge ER - TY - JOUR A1 - Dybiec, Bartlomiej A1 - Capala, Karol A1 - Chechkin, Aleksei V. A1 - Metzler, Ralf T1 - Conservative random walks in confining potentials JF - Journal of physics : A, Mathematical and theoretical N2 - Levy walks are continuous time random walks with spatio-temporal coupling of jump lengths and waiting times, often used to model superdiffusive spreading processes such as animals searching for food, tracer motion in weakly chaotic systems, or even the dynamics in quantum systems such as cold atoms. In the simplest version Levy walks move with a finite speed. Here, we present an extension of the Levy walk scenario for the case when external force fields influence the motion. The resulting motion is a combination of the response to the deterministic force acting on the particle, changing its velocity according to the principle of total energy conservation, and random velocity reversals governed by the distribution of waiting times. For the fact that the motion stays conservative, that is, on a constant energy surface, our scenario is fundamentally different from thermal motion in the same external potentials. In particular, we present results for the velocity and position distributions for single well potentials of different steepness. The observed dynamics with its continuous velocity changes enriches the theory of Levy walk processes and will be of use in a variety of systems, for which the particles are externally confined. KW - Levy walk KW - conservative random walks KW - Levy flight Y1 - 2018 U6 - https://doi.org/10.1088/1751-8121/aaefc2 SN - 1751-8113 SN - 1751-8121 VL - 52 IS - 1 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Sandev, Trifce A1 - Tomovski, Zivorad A1 - Dubbeldam, Johan L. A. A1 - Chechkin, Aleksei V. T1 - Generalized diffusion-wave equation with memory kernel JF - Journal of physics : A, Mathematical and theoretical N2 - We study generalized diffusion-wave equation in which the second order time derivative is replaced by an integro-differential operator. It yields time fractional and distributed order time fractional diffusion-wave equations as particular cases. We consider different memory kernels of the integro-differential operator, derive corresponding fundamental solutions, specify the conditions of their non-negativity and calculate the mean squared displacement for all cases. In particular, we introduce and study generalized diffusion-wave equations with a regularized Prabhakar derivative of single and distributed orders. The equations considered can be used for modeling the broad spectrum of anomalous diffusion processes and various transitions between different diffusion regimes. KW - diffusion-wave equation KW - Mittag-Leffler function KW - anomalous diffusion Y1 - 2018 U6 - https://doi.org/10.1088/1751-8121/aaefa3 SN - 1751-8113 SN - 1751-8121 VL - 52 IS - 1 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Warditz, Vladislava Maria T1 - Русское имянаречение Нового времени BT - социально-культурные и политико� идеологические механизмы антропонимических сдвигов BT - Socio-cultural and political ideological mechanisms of anthroponymic shifts JF - Voprosy onomastiki N2 - The author stems from the premise that modern anthroponymy effectively incorporates data from related fields of knowledge, primarily those of cultural and political history, thus getting enlarged through interdisciplinary research. An integrated approach allows one to deduce the extra-linguistic mechanisms which lay behind anthroponymic changes. In the same vein, the present paper focuses on the dynamics within the Russian anthroponymic paradigm caused by the changing vectors of political, ideological, cultural, and religious identity in the historical perspective of the New Time (1700-1920s). The study aims to establish the connection between specific trends in naming and the precedent names, events, and texts of political, cultural, and religious life. The mechanisms of anthroponymic shifts are illustrated by the cases of individual names becoming socially significant in a particular historical context. Using interdisciplinary methods of cultural anthropology, the study builds on textual sources, primarily name indexes to the collections of works by outstanding cultural figures and scholars, and biographical dictionaries. Some examples of pragmatic naming strategies in works of art (literature, opera, cinema) are also provided. Preliminary findings reveal some major trends in the Russian anthroponymic system of the New Age such as Europeization vs. Russification, modernization vs. archaization, as well as their synthesis. These tendencies remain key up to the present day and can be traced and characteristically defined within a set (or corpus) of names relating to the particular epoch, in terms of their frequency and the parameters of the sociolinguistic distribution. The diachronic perspective of the study also supports the sociolinguistic observation that the newly introduced names, which are currently in use, have a pronounced social resonance, which is getting neutralized as their frequency increases. Further development of the topic implies, among other things, statistical verification of preliminary findings. T2 - Russian Name-Giving of the New Time KW - Russian name giving KW - causes of anthroponymic shifts KW - Europeization KW - archaization KW - New Time KW - cultural paradigm KW - identity Y1 - 2018 U6 - https://doi.org/10.15826/vopr_onom.2019.16.2.018 SN - 1994-2400 SN - 1994-2451 VL - 16 IS - 2 SP - 129 EP - 144 PB - Uralʹskij federalʹnyj universitet CY - Ekaterinenburg ER - TY - JOUR A1 - Bai, Yongliang A1 - Dong, Dongdong A1 - Brune, Sascha A1 - Wu, Shiguo A1 - Wang, Zhenjie T1 - Crustal stretching style variations in the northern margin of the South China Sea JF - Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth N2 - Linking deep seismic profiles with regional-scale gravity inversion is a powerful tool to deduce the architecture of rifted margins and their structural evolution. Here we map upper and lower crustal thicknesses of the northern South China Sea (SCS) margin in order to investigate the occurrence of depth-dependent crustal extension from the proximal to the distal margin. By comparing upper and lower crustal stretching factors, we find that the northern margin of the SCS is segmented in three parts: (1) sedimentary basins where upper crust is stretched more than lower crust, (2) distal margin where lower crust is stretched more than upper crust, (3) mostly proximal margin regions where the two layers have similar stretching factors. Our results suggest that sedimentary basins and distal margin prominently feature depth-dependent extension, however accommodated by different processes. While differential thinning within sedimentary basins appears to be governed by lateral pressure variations inducing lower crustal flow, we suggest the distal margin to be affected by a combination of mantle flow-induced lower crustal shearing and sequential fault activity during crustal hyper-extension. KW - Crustal stretching style KW - Lower crustal flow KW - The northern margin of the South China Sea KW - Gravity inversion KW - Sediment load KW - Divergent mantle flow Y1 - 2018 U6 - https://doi.org/10.1016/j.tecto.2018.12.012 SN - 0040-1951 SN - 1879-3266 VL - 751 SP - 1 EP - 12 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Müller, Jörg A1 - Boch, Steffen A1 - Prati, Daniel A1 - Socher, Stephanie A. A1 - Pommer, Ulf A1 - Hessenmöller, Dominik A1 - Schall, Peter A1 - Schulze, Ernst Detlef A1 - Fischer, Markus T1 - Effects of forest management on bryophyte species richness in Central European forests JF - Forest ecology and management N2 - We studied the effect of three major forest management types (unmanaged beech, selection beech, and age class forests) and stand variables (SMId, soil pH, proportion of conifers, litter cover, deadwood cover, rock cover and cumulative cover of woody trees and shrubs) on bryophyte species richness in 1050 forest plots in three regions in Germany. In addition, we analysed the species richness of four ecological guilds of bryophytes according to their colonized substrates (deadwood, rock, soil, bark) and the number of woodland indicator bryophyte species. Beech selection forests turned out to be the most species rich management type, whereas unmanaged beech forests revealed even lower species numbers than age-class forests. Increasing conifer proportion increased bryophyte species richness but not the number of woodland indicator bryophyte species. The richness of the four ecological guilds mainly responded to the abundance of their respective substrate. We conclude that the permanent availability of suitable substrates is most important for bryophyte species richness in forests, which is not stringently linked to management type. Therefore, managed age-class forests and selection forests may even exceed unmanaged forests in bryophyte species richness due to higher substrate supply and therefore represent important habitats for bryophytes. Typical woodland indicator bryophytes and their species richness were negatively affected by SMId (management intensity) and therefore better indicate forest integrity than the species richness of all bryophytes. Nature conservation efforts should focus on the reduction of management intensity. Moreover, maintaining and increasing a variability of substrates and habitats, such as coarse woody debris, increasing structural heterogeneity by retaining patches with groups of old, mature to over-mature trees in managed forests, maintaining forest climate conditions by silvicultural methods that assure stand continuity, e.g. by selection cutting rather than clear cutting and shelterwood logging might promote bryophyte diversity and in particular the one of woodland indicator bryophytes. KW - Beech forests KW - Conifer plantations KW - Cryptogams KW - Ecological guilds KW - Forest management KW - Temperate forests KW - Selection vs. age-class forests KW - Unmanaged vs. managed forests KW - Woodland indicator species Y1 - 2018 U6 - https://doi.org/10.1016/j.foreco.2018.10.019 SN - 0378-1127 SN - 1872-7042 VL - 432 SP - 850 EP - 859 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kwiatkowska, Maria Magdalena A1 - Julkowski, Tomasz A1 - Rogoza, Radoslaw A1 - Zemojtel-Piotrowska, Magdalena A1 - Fatfouta, Ramzi T1 - Narcissism and trust BT - Differential impact of agentic, antagonistic, and communal narcissism JF - Personality and individual differences : an international journal of research into the structure and development of personality, and the causation of individual differences N2 - Previous research has shown that individuals high in narcissism mistrust others, yet little is known about narcissism's relation to trust. In the current study (N = 727), we aim to close this gap in the literature by examining the relationship between facets of trust (i.e., cognitive bias in the evaluation of others and personal trustworthiness) and facets of grandiose narcissism (i.e., agentic, antagonistic, and communal). We strive to answer the question whether narcissistic individuals believe that others are reliable, honest, and benevolent (how they perceive others) and whether they present themselves as trusting of others (how they perceive themselves). We posit and show that agentic narcissism is not related to any of the studied trust facets, suggesting that the concept of trust is not relevant to their self-image. In contrast, antagonistic narcissism is negatively related to perceiving others and oneself as trustful, and communal narcissism is positively related to these trust facets, purportedly due to communal self-enhancement. We discuss our findings of the Narcissistic Admiration and Rivalry Concept as well as to the Agency-Communion model of grandiose narcissism. KW - Grandiose narcissism KW - Trust KW - Narcissistic Admiration and Rivalry Concept KW - Agency-Communion model of narcissism Y1 - 2018 U6 - https://doi.org/10.1016/j.paid.2018.08.027 SN - 0191-8869 VL - 137 SP - 139 EP - 143 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Brechun, Katherine Emily A1 - Arndt, Katja Maren A1 - Woolley, G. Andrew T1 - Selection of protein-protein interactions of desired affinities with a bandpass circuit JF - Journal of molecular biology : JMB N2 - We have developed a genetic circuit in Escherichia coli that can be used to select for protein-protein interactions of different strengths by changing antibiotic concentrations in the media. The genetic circuit links protein-protein interaction strength to beta-lactamase activity while simultaneously imposing tuneable positive and negative selection pressure for beta-lactamase activity. Cells only survive if they express interacting proteins with affinities that fall within set high- and low-pass thresholds; i.e. the circuit therefore acts as a bandpass filter for protein-protein interactions. We show that the circuit can be used to recover protein-protein interactions of desired affinity from a mixed population with a range of affinities. The circuit can also be used to select for inhibitors of protein-protein interactions of defined strength. (C) 2018 Elsevier Ltd. All rights reserved. KW - synthetic biology KW - genetic circuit KW - biological engineering KW - protein-protein interactions KW - twin-arginine translocation KW - selection system Y1 - 2018 U6 - https://doi.org/10.1016/j.jmb.2018.11.011 SN - 0022-2836 SN - 1089-8638 VL - 431 IS - 2 SP - 391 EP - 400 PB - Elsevier CY - London ER - TY - JOUR A1 - Kruse, Julia A1 - Kummer, Volker A1 - Shivas, Roger G. A1 - Thines, Marco T1 - The first smut fungus, Thecaphora anthemidis sp nov (Glomosporiaceae), described from Anthemis (Asteraceae) JF - MycoKeys N2 - There are 63 known species of Thecaphora (Glomosporiaceae, Ustilaginomycotina), a third of which occur on Asteraceae. These smut fungi produce yellowish-brown to reddish-brown masses of spore balls in specific, mostly regenerative, plant organs. A species of Thecaphora was collected in the flower heads of Anthemis chia (Anthemideae, Asteraceae) on Rhodes Island, Greece, in 2015 and 2017, which represents the first smut record of a smut fungus on a host plant species in this tribe. Based on its distinctive morphology, host species and genetic divergence, this species is described as Thecaphora anthemidis sp. nov. Molecular barcodes of the ITS region are provided for this and several other species of Thecaphora. A phylogenetic and morphological comparison to closely related species showed that Th. anthemidis differed from other species of Thecaphora. Thecaphora anthemidis produced loose spore balls in the flower heads and peduncles of Anthemis chia unlike other flower-infecting species. KW - Glomosporiaceae KW - host specificity KW - internal transcribed spacer KW - molecular phylogenetics KW - smut fungi Y1 - 2018 U6 - https://doi.org/10.3897/mycokeys.41.28454 SN - 1314-4057 SN - 1314-4049 IS - 41 SP - 39 EP - 50 PB - Pensoft Publ. CY - Sofia ER - TY - JOUR A1 - Bleifuss, Tobias A1 - Bornemann, Leon A1 - Johnson, Theodore A1 - Kalashnikov, Dmitri A1 - Naumann, Felix A1 - Srivastava, Divesh T1 - Exploring Change BT - a new dimension of data analytics JF - Proceedings of the VLDB Endowment N2 - Data and metadata in datasets experience many different kinds of change. Values axe inserted, deleted or updated; rows appear and disappear; columns are added or repurposed, etc. In such a dynamic situation, users might have many questions related to changes in the dataset, for instance which parts of the data are trustworthy and which are not? Users will wonder: How many changes have there been in the recent minutes, days or years? What kind of changes were made at which points of time? How dirty is the data? Is data cleansing required? The fact that data changed can hint at different hidden processes or agendas: a frequently crowd-updated city name may be controversial; a person whose name has been recently changed may be the target of vandalism; and so on. We show various use cases that benefit from recognizing and exploring such change. We envision a system and methods to interactively explore such change, addressing the variability dimension of big data challenges. To this end, we propose a model to capture change and the process of exploring dynamic data to identify salient changes. We provide exploration primitives along with motivational examples and measures for the volatility of data. We identify technical challenges that need to be addressed to make our vision a reality, and propose directions of future work for the data management community. Y1 - 2018 U6 - https://doi.org/10.14778/3282495.3282496 SN - 2150-8097 VL - 12 IS - 2 SP - 85 EP - 98 PB - Association for Computing Machinery CY - New York ER - TY - JOUR A1 - Duydu, Yalcin A1 - Basaran, Nursen A1 - Aydin, Sevtap A1 - Ustundag, Aylin A1 - Yalcin, Can Özgür A1 - Anlar, Hatice Gul A1 - Bacanli, Merve A1 - Aydos, Kaan A1 - Atabekoglu, Cem Somer A1 - Golka, Klaus A1 - Ickstadt, Katja A1 - Schwerdtle, Tanja A1 - Werner, Matthias A1 - Meyer, Sören A1 - Bolt, Hermann M. T1 - Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions JF - Archives of toxicology : official journal of EUROTOX N2 - Boric acid and sodium borates are currently classified in the EU-CLP regulation as "toxic to reproduction" under "Category 1B", with hazard statement of H360FD. However, so far field studies on male reproduction in China and in Turkey could not confirm such boron-associated toxic effects. As validation by another independent study is still required, the present study has investigated possible boron-associated effects on male reproduction in workers (n = 212) under different boron exposure conditions. The mean daily boron exposure (DBE) and blood boron concentration of workers in the extreme exposure group (n = 98) were 47.17 +/- 17.47 (7.95-106.8) mg B/day and 570.6 +/- 160.1 (402.6-1100) ng B/g blood, respectively. Nevertheless, boron-associated adverse effects on semen parameters, as well as on FSH, LH and total testosterone levels were not seen, even within the extreme exposure group. With this study, a total body of evidence has accumulated that allows to conclude that male reproductive effects are not relevant to humans, under any feasible and realistic conditions of exposure to inorganic boron compounds. KW - Boron exposure KW - Boric acid KW - Reproductive toxicity KW - FSH KW - LH KW - Testosterone KW - Semen parameters Y1 - 2018 U6 - https://doi.org/10.1007/s00204-018-2296-7 SN - 0340-5761 SN - 1432-0738 VL - 92 IS - 10 SP - 3051 EP - 3059 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Latour, Marilyn A1 - Randall, Suzanna K. A1 - Calamida, Annalisa A1 - Geier, Stephan Alfred A1 - Moehler, Sabine T1 - The ultimate spectroscopic census of extreme horizontal branch stars in omega Centauri JF - Astronomy and astrophysics : an international weekly journal N2 - The presence of extreme horizontal branch (EHB) and blue hook stars in some Galactic globular clusters (GGCs) constitutes one of the remaining mysteries of stellar evolution. While several evolutionary scenarios have been proposed to explain the characteristics of this peculiar population of evolved stars, their observational verification has been limited by the availability of spectroscopic data for a statistically significant sample of such objects in any single GGC. We recently launched the SHOTGLAS project with the aim of providing a comprehensive picture of this intriguing stellar population in terms of spectroscopic properties for all readily accessible GGCs hosting an EHB. In this first paper, we focus on omega Cen, a peculiar, massive GGC that hosts multiple stellar populations. We use non-LTE model atmospheres to derive atmospheric parameters (Te ff, log g and N(He) / N(H)) and spectroscopic masses for 152 EHB stars in the cluster. This constitutes the largest spectroscopic sample of EHB stars ever analyzed in a GGC and represents similar to 20% of the EHB population of omega Cen. We also search for close binaries among these stars based on radial velocity variations. Our results show that the EHB population of omega Cen is divided into three spectroscopic groups that are very distinct in the Te ff helium abundance plane. The coolest sdB-type stars (Te ff. 30 000 K) have a hydrogen-rich atmosphere, populate the theoretical EHB region in the Te ff log g plane, and form 26% of our sample. The hottest sdO-type stars (Te ff & 42 000 K) make up 10% of the sample, have a hydrogen-rich atmosphere and are thought to be in a post-EHB evolutionary phase. The majority of our sample is found at intermediate temperatures and consists of sdOB stars that have roughly solar or super-solar atmospheric helium abundances. It is these objects that constitute the blue hook at V > 18 : 5 mag in the omega Cen color-magnitude diagram. Interestingly, the helium-enriched sdOBs do not have a significant counterpart population in the Galactic field, indicating that their formation is dependent on the particular environment found in omega Cen and other select GGCs. Another major di ff erence between the EHB stars in omega Cen and the field is the fraction of close binaries. From our radial velocity survey we identify two binary candidates, however no orbital solutions could be determined. We estimate an EHB close binary fraction of similar to 5% in omega Cen. This low fraction is in line with findings for other GGCs, but in sharp contrast to the situation in the field, where around 50% of the sdB stars reside in close binaries. Finally, the mass distribution derived is very similar for all three spectroscopic groups, however the average mass (0.38 M fi) is lower than that expected from stellar evolution theory. While this mass conundrum has previously been noted for EHB stars in omega Cen, it so far appears to be unique to that cluster. KW - stars: atmospheres KW - stars: horizontal-branch KW - subdwarfs KW - stars: fundamental parameters KW - binaries: close KW - globular clusters: individual: NGC5139 Y1 - 2018 U6 - https://doi.org/10.1051/0004-6361/201833129 SN - 1432-0746 VL - 618 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Goychuk, Igor T1 - Viscoelastic subdiffusion in a random Gaussian environment JF - Physical chemistry, chemical physics : a journal of European Chemical Societies N2 - Viscoelastic subdiffusion governed by a fractional Langevin equation is studied numerically in a random Gaussian environment modeled by stationary Gaussian potentials with decaying spatial correlations. This anomalous diffusion is archetypal for living cells, where cytoplasm is known to be viscoelastic and a spatial disorder also naturally emerges. We obtain some first important insights into it within a model one-dimensional study. Two basic types of potential correlations are studied: short-range exponentially decaying and algebraically slow decaying with an infinite correlation length, both for a moderate (several kBT, in the units of thermal energy), and strong (5–10kBT) disorder. For a moderate disorder, it is shown that on the ensemble level viscoelastic subdiffusion can easily overcome the medium's disorder. Asymptotically, it is not distinguishable from the disorder-free subdiffusion. However, a strong scatter in single-trajectory averages is nevertheless seen even for a moderate disorder. It features a weak ergodicity breaking, which occurs on a very long yet transient time scale. Furthermore, for a strong disorder, a very long transient regime of logarithmic, Sinai-type diffusion emerges. It can last longer and be faster in the absolute terms for weakly decaying correlations as compared with the short-range correlations. Residence time distributions in a finite spatial domain are of a generalized log-normal type and are reminiscent also of a stretched exponential distribution. They can be easily confused for power-law distributions in view of the observed weak ergodicity breaking. This suggests a revision of some experimental data and their interpretation. Y1 - 2018 U6 - https://doi.org/10.1039/c8cp05238g SN - 1463-9076 SN - 1463-9084 VL - 20 IS - 37 SP - 24140 EP - 24155 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Cook, Kristen L. A1 - Andermann, Christoff A1 - Gimbert, Florent A1 - Adhikari, Basanta Raj A1 - Hovius, Niels T1 - Glacial lake outburst floods as drivers of fluvial erosion in the Himalaya JF - Science N2 - Himalayan rivers are frequently hit by catastrophic floods that are caused by the failure of glacial lake and landslide dams; however, the dynamics and long-term impacts of such floods remain poorly understood. We present a comprehensive set of observations that capture the July 2016 glacial lake outburst flood (GLOF) in the Bhotekoshi/Sunkoshi River of Nepal. Seismic records of the flood provide new insights into GLOF mechanics and their ability to mobilize large boulders that otherwise prevent channel erosion. Because of this boulder mobilization, GLOF impacts far exceed those of the annual summer monsoon, and GLOFs may dominate fluvial erosion and channel-hillslope coupling many tens of kilometers downstream of glaciated areas. Long-term valley evolution in these regions may therefore be driven by GLOF frequency and magnitude, rather than by precipitation. Y1 - 2018 U6 - https://doi.org/10.1126/science.aat4981 SN - 0036-8075 SN - 1095-9203 VL - 362 IS - 6410 SP - 53 EP - 57 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Drobyshev, Evgenii J. A1 - Solovyev, Nikolay D. A1 - Gorokhovskiy, Boris M. A1 - Kashuro, Vadim A. T1 - Accumulation Patterns of Sub-chronic Aluminum Toxicity Model After Gastrointestinal Administration in Rats JF - Biological Trace Element Research N2 - Although aluminum chronic neurotoxicity is well documented, there are no well-established experimental protocols of Al exposure. In the current study, toxic effects of sub-chronic Al exposure have been evaluated in outbreed male rats (gastrointestinal administration). Forty animals were used: 10 were administered with AlCl3 water solution (2 mg/kg Al per day) for 1 month, 10 received the same concentration of AlCl3 for 3 month, and 20 (10 per observation period) saline as control. After 30 and 90 days, the animals underwent behavioral tests: open field, passive avoidance, extrapolation escape task, and grip strength. At the end of the study, the blood, liver, kidney, and brain were excised for analytical and morphological studies. The Al content was measured by inductively coupled plasma mass-spectrometry. Essential trace elements-Co, Cr, Cu, Fe, Mg, Mn, Mo, Se, and Zn-were measured in whole blood samples. Although no morphological changes were observed in the brain, liver, or kidney for both exposure terms, dose-dependent Al accumulation and behavioral differences (increased locomotor activity after 30 days) between treatment and control groups were indicated. Moreover, for 30 days exposure, strong positive correlation between Al content in the brain and blood for individual animals was established, which surprisingly disappeared by the third month. This may indicate neural barrier adaptation to the Al exposure or the saturation of Al transport into the brain. Notably, we could not see a clear neurodegeneration process after rather prolonged sub-chronic Al exposure, so probably longer exposure periods are required. KW - Aluminum KW - Neurotoxicity KW - Rats KW - Per oral administration KW - Sub-chronic exposure KW - Trace elements Y1 - 2018 U6 - https://doi.org/10.1007/s12011-018-1247-8 SN - 0163-4984 SN - 1559-0720 VL - 185 IS - 2 SP - 384 EP - 394 PB - Humana Press Inc. CY - Totowa ER - TY - JOUR A1 - van der Meij, Marijn W. A1 - Temme, Arnaud J. A. M. A1 - Lin, H. S. A1 - Gerke, Horst H. A1 - Sommer, Michael T1 - On the role of hydrologic processes in soil and landscape evolution modeling BT - concepts, complications and partial solutions JF - Earth science reviews : the international geological journal bridging the gap between research articles and textbooks N2 - The ability of water to transport and transform soil materials is one of the main drivers of soil and landscape development. In turn, soil and landscape properties determine how water is distributed in soil landscapes. Understanding the complex dynamics of this co-evolution of soils, landscapes and the hydrological system is fundamental in adapting land management to changes in climate. Soil-Landscape Evolution Models (SLEMs) are used to simulate the development and evolution of soils and landscapes. However, many hydrologic processes, such as preferential flow and subsurface lateral flow, are currently absent in these models. This limits the applicability of SLEMs to improve our understanding of feedbacks in the hydro-pedo-geomorphological system. Implementation of these hydrologic processes in SLEMs faces several complications related to calculation demands, limited methods for linking pedogenic and hydrologic processes, and limited data on quantification of changes in the hydrological system over time. In this contribution, we first briefly review processes and feedbacks in soil-landscape-hydrological systems. Next, we elaborate on the development required to include these processes in SLEMs. We discuss the state-of-the-art knowledge, identify complications, give partial solutions and suggest important future development. The main requirements for incorporating hydrologic processes in SLEMs are: (1) designing a model framework that can deal with varying timescales for different sets of processes, (2) developing and implementing methods for simulating pedogenesis as a function of water flow, (3) improving and implementing knowledge on the evolution and dynamics of soil hydraulic properties over different timescales, and (4) improving the database on temporal changes and dynamics of flow paths. Y1 - 2018 U6 - https://doi.org/10.1016/j.earscirev.2018.09.001 SN - 0012-8252 SN - 1872-6828 VL - 185 SP - 1088 EP - 1106 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Calsamiglia, Aleix A1 - Garcia-Comendador, Julian A1 - Fortesa, Josep A1 - Lopez-Tarazon, José Andrés A1 - Crema, S. A1 - Cavalli, M. A1 - Calvo-Cases, A. A1 - Estrany, Joan T1 - Effects of agricultural drainage systems on sediment connectivity in a small Mediterranean lowland catchment JF - Geomorphology : an international journal on pure and applied geomorphology N2 - Traditional drainage systems combining man-made channels and subsurface tile drains have been used since Roman times to control water excess in Mediterranean lowland regions, favouring adequate soil water regime for agriculture purposes. However, mechanization of agriculture, abandonment or land use changes lead to a progressive deterioration of these drains in the last decades. The effects of these structures on hydrological and sediment dynamics have been previously analyzed in a small Mediterranean lowland catchment (Can Revull, Mallorca, Spain, 1.4 km2) by establishing an integrated sediment budget with a multi-technique approach. Moreover, the recent advances in morphometric techniques enable the completion of this analysis by the accurate identification of active areas (i.e. sources, pathway links, and sinks) and improve the understanding of (de-)coupling mechanisms of water and sediment linkages. In this study, the Borselli's index of connectivity (IC; Cavalli et al. (2013)'s version) derived from a LiDAR-based high resolution DEM (>1 pt m−2; RMSE < 0.2 m) was used to evaluate the spatial patterns of sediment connectivity of the catchment under two different scenarios: (1) the current scenario, including an accurate representation of the 3800 m of artificial channels and levees (CS - Channelled Scenario), and (2) a hypothetical scenario in which these anthropogenic features were removed (US - Unchannelled Scenario). Design and configuration of the drainage system in Can Revull generated changes favouring lateral decoupling between different compartments, with hillslopes-floodplain and floodplain-channels relationships, showing a general decrease of IC values, and high longitudinal connectivity along the artificial channel network. Field observations corroborated these results: structures enabled rapid drainage of the water excess also promoting low surface runoff within the field crops, proving to be an effective management practice for erosion control in agricultural Mediterranean lowland catchments. By contrast, US demonstrated that the abandonment of the current agricultural practices and the subsequent destruction of the drainage system could lead the higher soil loss rates owning to more intense/effective processes of sediment connectivity. KW - Sediment connectivity KW - Traditional drainage systems KW - Catchment management KW - Soil erosion KW - LiDAR Y1 - 2018 U6 - https://doi.org/10.1016/j.geomorph.2018.06.011 SN - 0169-555X SN - 1872-695X VL - 318 SP - 162 EP - 171 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Balderjahn, Ingo A1 - Peyer, Mathias A1 - Seegebarth, Barbara A1 - Wiedmann, Klaus-Peter A1 - Weber, Anja T1 - The many faces of sustainability-conscious consumers BT - a category-independent typology JF - Journal of Business Research N2 - Responding to the global call for a "sustainable economy" requires meaningful insights into sustainability-conscious consumers and their actual buying behaviors. Sustainable consumption is not an all-or-nothing phenomenon because it encompasses several distinct behavioral patterns and consumption types. Therefore, companies are well advised to recognize multiple types of sustainability-conscious consumers with different expectations, attitudes, and values and to implement targeting strategies that do not rest on the assumption of homogeneity. Thus, the objective of this study is to provide a more fine-grained picture of (un)sustainable consumer segments and their differentiated effects in different product markets. Based on three large datasets, we create a robust six-segment typology of consumer consciousness regarding sustainable consumption. By using panel data on actual purchases, the results show not only that sustainability concerns significantly positively influence actual sustainable purchases, as expected, but also that sustainable buying can occur independently of sustainability concerns. KW - Sustainability KW - Consumer typology KW - Consciousness regarding sustainable KW - consumption KW - Purchasing panel data KW - Human values Y1 - 2018 U6 - https://doi.org/10.1016/j.jbusres.2018.05.022 SN - 0148-2963 SN - 1873-7978 VL - 91 SP - 83 EP - 93 PB - Elsevier CY - New York ER - TY - JOUR A1 - van Grunsven, Roy Hendrikus Antonius A1 - Jaehnichen, David A1 - Grubisic, Maja A1 - Hölker, Franz T1 - Slugs (Arionidae) benefit from nocturnal artificial illumination JF - Journal of Experimental Zoology Part A: Ecological and Integrative Physiology N2 - Artificial illumination increases around the globe and this has been found to affect many groups of organisms and ecosystems. By manipulating nocturnal illumination using one large experimental field site with 24 streetlights and one dark control, we assessed the impact of artificial illumination on slugs over a period of 4 years. The number of slugs, primarily Arionidae, increased strongly in the illuminated site but not on the dark site. There are several nonexclusive explanations for this effect, including reduced predation and increased food quality in the form of carcasses of insects attracted by the light. As slugs play an important role in ecosystems and are also important pest species, the increase of slugs under artificial illumination cannot only affect ecosystem functioning but also have important economic consequences. KW - ALAN KW - Arionidae KW - gastropoda KW - light pollution KW - phototaxis Y1 - 2018 U6 - https://doi.org/10.1002/jez.2170 SN - 2471-5646 VL - 329 IS - 8-9 SP - 429 EP - 433 PB - Wiley CY - Hoboken ER -